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sildenafil in pregnancy

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https://www.readbyqxmd.com/read/27861916/sildenafil-therapy-for-fetal-cardiovascular-dysfunction-during-hypoxic-development-studies-in-the-chick-embryo
#1
Nozomi Itani, Katie L Skeffington, Christian Beck, Dino A Giussani
There is a need for developing clinically translatable therapy for preventing fetal origins of cardiovascular disease in pregnancy complicated by chronic fetal hypoxia. Evidence shows that sildenafil protects placental perfusion and fetal growth. However, whether beneficial effects of sildenafil transcend onto the fetal heart and circulation in complicated development is unknown. We isolated the direct effects of sildenafil on the fetus using the chick embryo and hypothesised that sildenafil also protects fetal cardiovascular function in hypoxic development...
November 12, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27821175/early-onset-fetal-growth-restriction-treated-with-the-long-acting-phosphodiesterase-5-inhibitor-tadalafil-a-case-report
#2
Mito Sakamoto, Kazuhiro Osato, Michiko Kubo, Masafumi Nii, Hiroaki Tanaka, Nao Murabayashi, Takashi Umekawa, Yuki Kamimoto, Tomoaki Ikeda
BACKGROUND: Severe early-onset fetal growth restriction occurs in 0.4 % of all pregnancies, and the prognoses of these patients are dismal. Severely growth-restricted fetuses (far below 500 g) are thought to be nonviable. Since there have not been effective treatments for such fetal patients, obstetricians have simply tried to identify the optimal timing for their delivery. There are a few reports suggesting that the phosphodiesterase type 5 inhibitor sildenafil has some limited beneficial effects on fetal growth, but there are no such reports on tadalafil, another derivative phosphodiesterase type 5 inhibitor which has a much longer half-life than sildenafil...
November 8, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27783532/thermosensitive-bioadhesive-gels-for-the-vaginal-delivery-of-sildenafil-citrate-in-vitro-characterization-and-clinical-evaluation-in-women-using-clomiphene-citrate-for-induction-of-ovulation
#3
Ghareb M Soliman, Gihan Fetih, Ahmed M Abbas
OBJECTIVE: The objective of this study is to develop and characterize in situ thermosensitive gels for the vaginal administration of sildenafil as a potential treatment of endometrial thinning occurring as a result of using clomiphene citrate for ovulation induction in women with type II eugonadotrophic anovulation. While sildenafil has shown promising results in the treatment of infertility in women, the lack of vaginal pharmaceutical preparation and the side effects associated with oral sildenafil limit its clinical effectiveness...
November 14, 2016: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/27645716/ep17-02-the-use-of-sildenafil-citrate-in-pregnancy-a-systematic-review
#4
R Negrini, R D Ferreira, R C Oliveira
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27586847/gonadal-dysfunction-in-chronic-kidney-disease
#5
Biff F Palmer, Deborah J Clegg
Sexual dysfunction is a common finding in both men and women with chronic kidney failure. Common disturbances include erectile dysfunction in men, menstrual abnormalities in women, and decreased libido and fertility in both sexes. These abnormalities are primarily organic in nature and are related to uremia as well as the other comorbid conditions that frequently occur in the chronic kidney failure patient. Fatigue and psycho social factors related to the presence of a chronic disease are also contributory factors...
September 1, 2016: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/27563258/sildenafil-citrate-for-the-management-of-fetal-growth-restriction-and-oligohydramnios
#6
Rana Choudhary, Kavita Desai, Hetal Parekh, Kedar Ganla
Fetal growth restriction (FGR) and preeclampsia are the major causes of neonatal morbidity and mortality, which affect up to 8% of all pregnancies. The pathogenesis in FGR is an abnormal trophoblastic invasion leading to compromised uteroplacental circulation. However, in spite of this understanding and identification of high-risk patients, the management options are limited. There are some new studies which have demonstrated the role of sildenafil citrate in improving vasodilatation of small myometrial vessels and therefore improvement in amniotic fluid index, fetal weight, and even uterine and umbilical artery Doppler patterns...
2016: International Journal of Women's Health
https://www.readbyqxmd.com/read/27521424/clinically-relevant-timing-of-antenatal-sildenafil-treatment-reduces-pulmonary-vascular-remodeling-in-congenital-diaphragmatic-hernia
#7
Daphne S Mous, Heleen M Kool, Marjon J Buscop-van Kempen, Anton H Koning, Oleh Dzyubachyk, Rene M H Wijnen, Dick Tibboel, Robbert J Rottier
Patients with congenital diaphragmatic hernia (CDH) suffer from severe pulmonary hypertension attributable to altered development of the pulmonary vasculature, which is often resistant to vasodilator therapy. Present treatment starts postnatally even though significant differences in the pulmonary vasculature are already present early during pregnancy. We examined the effects of prenatal treatment with the phosphodiesterase-5 inhibitor sildenafil on pulmonary vascular development in experimental CDH starting at a clinically relevant time...
October 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27432857/maternal-administration-of-sildenafil-citrate-alters-fetal-and-placental-growth-and-fetal-placental-vascular-resistance-in-the-growth-restricted-ovine-fetus
#8
Charlotte Oyston, Joanna L Stanley, Mark H Oliver, Frank H Bloomfield, Philip N Baker
Intrauterine growth restriction (IUGR) causes short- and long-term morbidity. Reduced placental perfusion is an important pathogenic component of IUGR; substances that enhance vasodilation in the uterine circulation, such as sildenafil citrate (sildenafil), may improve placental blood flow and fetal growth. This study aimed to examine the effects of sildenafil in the growth-restricted ovine fetus. Ewes carrying singleton pregnancies underwent insertion of vascular catheters, and then, they were randomized to receive uterine artery embolization (IUGR) or to a control group...
September 2016: Hypertension
https://www.readbyqxmd.com/read/27400005/perinatal-and-hemodynamic-evaluation-of-sildenafil-citrate-for-preeclampsia-treatment-a-randomized-controlled-trial
#9
Alberto Trapani, Luis Flavio Gonçalves, Thamyris Finger Trapani, Simone Vieira, Marilen Pires, Maria Marlene de Souza Pires
OBJECTIVE: To evaluate whether therapy with sildenafil citrate prolongs gestation in women with preeclampsia. METHODS: In a randomized double-blind, placebo-controlled trial, 100 singleton pregnancies with preeclampsia between 24 and 33 weeks of gestation were randomized to 50 mg oral sildenafil citrate every 8 hours or placebo. The primary outcome was prolongation of pregnancy from randomization to delivery. Secondary outcomes were changes in resistance indices of uterine, umbilical, and middle cerebral arteries by Doppler, fetal and maternal complications, and adverse neonatal outcomes...
August 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27341074/inhaled-iloprost-for-chronic-thromboembolic-pulmonary-hypertension-cteph-during-pregnancy-a-case-report
#10
Michelle Horng, Insaf Mohammad, Zachary R Smith, Rana L Awdish, Hector R Cajigas
Chronic thromboembolic pulmonary hypertension (CTEPH) is a subset of pulmonary hypertension caused by acute and recurrent pulmonary emboli. Pulmonary thromboendarterectomy is the treatment of choice, but 10-50% of patients are ineligible for this procedure. We describe the case of a 25-year-old, morbidly obese (228-kg, body mass index 83.5 kg/m(2) ) pregnant woman (G3 P2 ) who presented at 24 weeks' gestation; bilateral pulmonary angiography revealed filling defects and confirmed the diagnosis of CTEPH. The patient was evaluated and deemed to present too high of a risk for pulmonary thromboendarterectomy, so a multidisciplinary team initiated medical therapy...
September 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/27270170/soluble-fms-like-tyrosine-kinase-1-promotes-angiotensin-ii-sensitivity-in-preeclampsia
#11
Suzanne D Burke, Zsuzsanna K Zsengellér, Eliyahu V Khankin, Agnes S Lo, Augustine Rajakumar, Jennifer J DuPont, Amy McCurley, Mary E Moss, Dongsheng Zhang, Christopher D Clark, Alice Wang, Ellen W Seely, Peter M Kang, Isaac E Stillman, Iris Z Jaffe, S Ananth Karumanchi
Preeclampsia is a hypertensive disorder of pregnancy in which patients develop profound sensitivity to vasopressors, such as angiotensin II, and is associated with substantial morbidity for the mother and fetus. Enhanced vasoconstrictor sensitivity and elevations in soluble fms-like tyrosine kinase 1 (sFLT1), a circulating antiangiogenic protein, precede clinical signs and symptoms of preeclampsia. Here, we report that overexpression of sFlt1 in pregnant mice induced angiotensin II sensitivity and hypertension by impairing endothelial nitric oxide synthase (eNOS) phosphorylation and promoting oxidative stress in the vasculature...
July 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27209378/the-effects-of-sildenafil-citrate-on-feto-placental-development-and-haemodynamics-in-a-rabbit-model-of-intrauterine-growth-restriction
#12
Jorge López-Tello, María Arias-Álvarez, Maria-Ángeles Jiménez-Martínez, Alicia Barbero-Fernández, Rosa María García-García, María Rodríguez, Pedro L Lorenzo, Laura Torres-Rovira, Susana Astiz, Antonio González-Bulnes, Pilar G Rebollar
The present study evaluated the effectiveness of sildenafil citrate (SC) to improve placental and fetal growth in a diet-induced rabbit model of intrauterine growth restriction (IUGR). Pregnant rabbits were fed either ad libitum (Group C) or restricted to 50% of dietary requirements (Group R) or restricted and treated with SC (Group SC). The treatment with SC improved placental development by increasing vascularity and vessel hypertrophy in the decidua. The assessment of feto-placental haemodynamics showed higher resistance and pulsatility indices at the middle cerebral artery (MCA) in fetuses treated with SC when compared with Group R, which had increased systolic peak and time-averaged mean velocities at the MCA...
May 23, 2016: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/27177526/sildenafil-treatment-in-a-nonsevere-hypertensive-murine-model-lowers-blood-pressure-without-reducing-fetal-growth
#13
Robyn P Roberts, Jerrie S Refuerzo, Francesca Ferrari, Alejandra E Ontiveros, Esther H Tamayo, Baha M Sibai, Sean C Blackwell, Monica Longo
BACKGROUND: Treatment of nonsevere hypertension during pregnancy is controversial. Sildenafil is a phosphodiesterase inhibitor that potentiates nitric oxide by promoting vasodilation. Nitric oxide plays a vital role in mediating the vascular adaptations during pregnancy. OBJECTIVE: The objective of the study was to determine whether treatment with sildenafil during pregnancy would lower maternal systolic blood pressure without adversely affecting fetal growth. STUDY DESIGN: Females with nonsevere hypertension (endothelial nitric oxide synthase(+/-)) were cross-bred with normotensive wild-type males...
September 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26978649/effects-of-sildenafil-citrate-and-heparin-treatments-on-placental-cell-morphology-in-a-murine-model-of-pregnancy-loss
#14
Rayana Leal Luna, Anne Gabrielle Vasconcelos, Ana Karolina Santana Nunes, Wilma Helena de Oliveira, Karla Patricia de Sousa Barbosa, Christina Alves Peixoto
Lipopolysaccharide (LPS) injections during pregnancy are well established as models for pregnancy complications, including fetal growth restriction (FGR), thrombophilia, preterm labor and abortion. Indeed, inflammation, as induced by LPS injection has been described as a pivotal factor in cases of miscarriage related to placental tissue damage. The phosphodiesterase-5 inhibitor sildenafil (Viagra®) is currently used to treat FGR cases in women, while low-molecular weight heparin (Fragmin®) is a standard treatment for recurrent miscarriage (RM)...
2016: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/26972897/placental-origins-of-adverse-pregnancy-outcomes-potential-molecular-targets-an-executive-workshop-summary-of-the-eunice-kennedy-shriver-national-institute-of-child-health-and-human-development
#15
REVIEW
John V Ilekis, Ekaterini Tsilou, Susan Fisher, Vikki M Abrahams, Michael J Soares, James C Cross, Stacy Zamudio, Nicholas P Illsley, Leslie Myatt, Christine Colvis, Maged M Costantine, David M Haas, Yoel Sadovsky, Carl Weiner, Erik Rytting, Gene Bidwell
Although much progress is being made in understanding the molecular pathways in the placenta that are involved in the pathophysiology of pregnancy-related disorders, a significant gap exists in the utilization of this information for the development of new drug therapies to improve pregnancy outcome. On March 5-6, 2015, the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health sponsored a 2-day workshop titled Placental Origins of Adverse Pregnancy Outcomes: Potential Molecular Targets to begin to address this gap...
July 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26817301/-strategies-of-sperm-collection-from-men-with-temporary-penile-erectile-dysfunction-on-the-day-of-oocyte-retrieval-and-the-outcomes-of-ivf-et
#16
Hong-yi Xu, Kai Deng, Qing-bing Luo, Xin Zhang, Xin Li, Chang-jun Zhang
OBJECTIVE: To search for the optimal strategies for sperm collection from the patient with temporary penile erectile dysfunction (ED) on the day of oocyte pick-up ( OPU) in in vitro fertilization embryo transfer (IVF-ET). METHODS: We retrospectively analyzed 93 cases of temporary ED on the OPU day of IVF-ET from January 2011 to May 2014, with fresh semen for 45 cases (group A), cryopreserved sperm before oocyte retrieval for 30 cases (group B), and frozen oocytes for 18 cases (group C)...
December 2015: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/26767411/reducing-the-risk-of-fetal-distress-with-sildenafil-study-ridstress-a-double-blind-randomised-control-trial
#17
RANDOMIZED CONTROLLED TRIAL
Liam Dunn, Vicki Flenady, Sailesh Kumar
BACKGROUND: Labour is perhaps the most hazardous time in pregnancy. As many as 20 % of cerebral palsy cases in term infants result from intrapartum events and up to 63 % of babies who develop intrapartum compromise have no prior risk factors. Sildenafil citrate (SC), a phosphodiesterase 5 inhibitor, improves uterine blood supply through vasodilatation and potentially could improve placental perfusion and hence reduce the risk of intrapartum fetal hypoxia. The aim of this study is to evaluate the efficacy of SC to reduce the risk of intrapartum fetal compromise and the need for emergency operative delivery...
January 14, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/26729752/sildenafil-treatment-ameliorates-the-maternal-syndrome-of-preeclampsia-and-rescues-fetal-growth-in-the-dahl-salt-sensitive-rat
#18
Ellen E Gillis, Jennifer N Mooney, Michael R Garrett, Joey P Granger, Jennifer M Sasser
Preeclampsia, a hypertensive disorder of pregnancy, is detrimental to both mother and fetus. There is currently no effective treatment, but sildenafil, a phosphodiesterase-5 inhibitor, has been proposed as a potential therapy to reduce blood pressure and improve uteroplacental perfusion in preeclamptic patients. We hypothesized that sildenafil would improve the maternal syndrome and fetal outcomes in the Dahl S rat model of superimposed preeclampsia. Dahl S rats were mated, and half received sildenafil (50 mg/kg per day, via food) from day 10 through day 20 of pregnancy...
March 2016: Hypertension
https://www.readbyqxmd.com/read/26667607/sildenafil-therapy-normalizes-the-aberrant-metabolomic-profile-in-the-comt-mouse-model-of-preeclampsia-fetal-growth-restriction
#19
Joanna L Stanley, Karolina Sulek, Irene J Andersson, Sandra T Davidge, Louise C Kenny, Colin P Sibley, Rupasri Mandal, David S Wishart, David I Broadhurst, Philip N Baker
Preeclampsia (PE) and fetal growth restriction (FGR) are serious complications of pregnancy, associated with greatly increased risk of maternal and perinatal morbidity and mortality. These complications are difficult to diagnose and no curative treatments are available. We hypothesized that the metabolomic signature of two models of disease, catechol-O-methyl transferase (COMT(-/-)) and endothelial nitric oxide synthase (Nos3(-/-)) knockout mice, would be significantly different from control C57BL/6J mice. Further, we hypothesised that any differences in COMT(-/-) mice would be resolved following treatment with Sildenafil, a treatment which rescues fetal growth...
December 15, 2015: Scientific Reports
https://www.readbyqxmd.com/read/26455018/-pregnant-woman-with-pulmonary-hypertension
#20
REVIEW
Małgorzata Peregud-Pogorzelska, Zdzisława Kornacewicz-Jach
Pulmonary hypertension is a disease with diverse etiology. According to the New ESC guidelines, pregnancy is contraindicated for a patent with pulmonary hypertension and qualify such patent to class IV NYHA, regardless of the reason of hypertension. Pregnancy is revived for a patient with pulmonary hypertension despite of the fact that recent treatment methods including specific therapy with the endothelin receptor antagonistst (bosentan), phosphodiesterase inhibitors (sildenafil) and prostacyclin analogs (iloprost) were introduced...
2015: Przegla̧d Lekarski
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