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staph lugdunensis

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https://www.readbyqxmd.com/read/27902368/coagulase-negative-staphylococci-pathogenesis-occurrence-of-antibiotic-resistance-genes-and-in-vitro-effects-of-antimicrobial-agents-on-biofilm-growing-bacteria
#1
Ewa Szczuka, Lucyna Jabłońska, Adam Kaznowski
Coagulase-negative staphylococci (CoNS) are opportunistic pathogens that particularly cause infections in patients with implanted medical devices. The present research was performed to study the virulence potential of 53 clinical isolates of Staphylococcus capitis, Staphylococcus auricularis, Staphylococcus lugdunensis, Staphylococcus simulans, Staphylococcus cohnii, and Staphylococcus caprae. All clinical strains were clonally unrelated. Isolates carried genes encoding resistance to β-lactam (mecA) (15%), aminoglycosides aac(6')/aph(2'') (11%), aph (3')-IIIa (15%), ant(4')-Ia (19%) and MLSB erm(A) (4%), erm(B) (13%), erm(C) (41%), msr(A) (11%) antibiotics...
October 19, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27885468/staphylococcus-lugdunensis-infections-filling-in-the-gaps-a-3-year-retrospective-review-from-a-comprehensive-cancer-center
#2
Lior Nesher, Jeffery Tarrand, Roy F Chemaly, Kenneth Vi Rolston
OBJECTIVE: Staphylococcus lugdunensis is considered to be more aggressive than other coagulase-negative staphylococci (CoNS). There are gaps in knowledge regarding the importance of isolating S. lugdunensis from different sources and in different patient subsets. Our objective was to describe the spectrum, clinical manifestations, and outcomes of infections caused by S. lugdunensis in patients with cancer. METHODS: A retrospective review of all cancer patients from whom S...
November 24, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27815957/staphylococcus-lugdunensis-septic-arthritis-of-a-native-knee-a-case-report
#3
John P Begly, Michael Sobieraj, Frank A Liporace, Alan Dayan
A 67-year-old man presented to orthopaedic care with a painful knee. Workup was consistent with septic arthritis of a native knee, and the patient underwent operative treatment. Cultures from the operating room were speciated to Staphylococcus lugdunensis. To the investigators' knowledge, this is the first reported S. lugdunensis infection in a peripheral joint in the absence of an orthopaedic prosthesis. Although traditionally associated with infectious endocarditis, S. lugdunensis has been identified as a causative agent in many organ systems, including orthopaedic infections...
November 2016: Bulletin of the Hospital for Joint Diseases
https://www.readbyqxmd.com/read/27790500/cavernous-sinus-thrombosis-due-to-streptococcus-mitis-and-staphylococcus-lugdunensis
#4
Sandhya Nagarakanti, Eliahu Bishburg, Melinda Brown
Cavernous Sinus Thrombosis (CST) is a rare, life-threatening condition that may result from the direct spread of infection from the nose, ears, teeth or sinuses. It is most commonly caused by Staphylococcus aureus and Streptococcus sp. We present a case of CST caused by Strepotococcus mitis and Staphylococcus lugdunensis. Early surgical intervention with aggressive medical management is needed as the syndrome carries a high mortality. To our knowledge this is the first case of CST associated with these two organisms...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27781969/-a-blood-culture-containing-coagulase-negative-staphylococci-not-always-due-to-contamination
#5
E C F Wagenaar, P van Wijngaarden, C M Verduin, D Beelen, R W van Etten
Staphylococcus lugdunensis (SL) is a species belonging to the group of coagulase-negative staphylococci (CNS). It can cause severe infections such as endocarditis. Three cases of endocarditis caused by SL are presented. The first case describes a 71-year-old man with a fever and endogenous endophthalmitis. The second case describes delirium in an 87-year-old woman, thought to be due to pneumonia. The third case describes a 76-year-old man with an infection of unknown origin. In all cases, the first blood cultures drawn were positive for CNS and considered to be contaminated...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27777118/the-occurrence-of-infective-endocarditis-with-staphylococcus-lugdunensis-bacteremia-a-retrospective-cohort-study-and-systematic-review
#6
Lemuel R Non, Carlos A Q Santos
BACKGROUND: Staphylococcus lugdunensis is a coagulase-negative staphylococcus with similar virulence characteristics as S. aureus. Whether S. lugdunensis causes infective endocarditis (IE) in a similar proportion of cases as S. aureus (reported to be 12.6% in a definitive multicenter prospective study) is unclear. METHODS: We conducted a retrospective cohort study of adult patients with at least one blood culture positive for S. lugdunensis at our institution from January 2006 to December 2014...
October 21, 2016: Journal of Infection
https://www.readbyqxmd.com/read/27773901/a-case-of-bacterial-meningitis-caused-by-methicillin-resistant-staphylococcus-lugdunensis-after-surgery
#7
Yasuhiro Sasaki, Ayumi Kanamaru, Hisae Uchida, Masataka Yano, Hiroshi Tada
An 51-year-old man had undergone surgery for Rathke's cleft cyst by transsphenoidal approach on October 2015. After the surgery, cerebrospinal fluid (CSF) rhinorrhea arose. Surgical treatment of CSF rhinorrhea was performed by the same approach. Ten days after reoperation, he suffered from severe headache, high fever, and nuchal rigidity. CSF findings indicated bacterial meningitis. CSF culture showed methicillin-resistant Staphylococcus lugdunensis. He received vancomycin intravenously for 19 days and recovered from the bacterial meningitis with no serious complication...
November 29, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27757046/ability-of-procalcitonin-to-diagnose-bacterial-infection-and-bacteria-types-compared-with-blood-culture-findings
#8
Yuji Watanabe, Nozomi Oikawa, Maya Hariu, Ryota Fuke, Masafumi Seki
Procalcitonin (PCT) and C-reactive protein serve as biomarkers of infection in patients with sepsis/bacteremia. The present study assessed the clinical characteristics of 280 patients with suspected sepsis who were admitted to Tohoku Medical and Pharmaceutical University Hospital between January 2012 and December 2013. Among the patients, 133 and 147 were positive and negative for PCT, respectively. Patients who were PCT positive were older and more frequently male, had reduced levels of platelets and albumin, and increased levels of aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, creatinine, and C-reactive protein...
2016: International Journal of General Medicine
https://www.readbyqxmd.com/read/27748222/staphylococcus-lugdunensis-endocarditis-in-children
#9
Marie-Paule Guillaume, François Dubos, François Godart
We report the case of a 2-year-old boy with severe Langerhans cell histiocytosis who had tricuspid endocarditis caused by Staphylococcus lugdunensis and required surgery despite appropriate antimicrobial therapy. Through this case and literature review of endocarditis caused by S. lugdunensis in children, we highlight pitfalls and mistakes to be avoided in the management of this rare but serious infection.
October 17, 2016: Cardiology in the Young
https://www.readbyqxmd.com/read/27704471/expression-purification-and-immobilization-of-tannase-from-staphylococcus-lugdunensis-mtcc-3614
#10
Amballa Chaitanyakumar, M Anbalagan
Enzymes find their applications in various industries, due to their error free conversion of substrate into product. Tannase is an enzyme used by various industries for degradation of tannin. Biochemical characterization of a specific enzyme from one organism to other is one of the ways to search for enzymes with better traits for industrial applications. Here, tannase encoding gene from Staphylococcus lugdunensis was cloned and suitability of the enzyme in various conditions was analysed to find its application in various industry...
December 2016: AMB Express
https://www.readbyqxmd.com/read/27704053/divergent-isoprenoid-biosynthesis-pathways-in-staphylococcus-species-constitute-a-drug-target-for-treating-infections-in-companion-animals
#11
Ana M Misic, Christine L Cain, Daniel O Morris, Shelley C Rankin, Daniel P Beiting
Staphylococcus species are a leading cause of skin and soft tissue infections in humans and animals, and the antibiotics used to treat these infections are often the same. Methicillin- and multidrug-resistant staphylococcal infections are becoming more common in human and veterinary medicine. From a "One Health" perspective, this overlap in antibiotic use and resistance raises concerns over the potential spread of antibiotic resistance genes. Whole-genome sequencing and comparative genomics analysis revealed that Staphylococcus species use divergent pathways to synthesize isoprenoids...
September 2016: MSphere
https://www.readbyqxmd.com/read/27660064/clinical-significance-of-coagulase-negative-staphylococci-other-than-s-epidermidis-blood-stream-isolates-at-a-tertiary-care-hospital
#12
Florian Hitzenbichler, Michaela Simon, Bernd Salzberger, Frank Hanses
PURPOSE: We retrospectively evaluated blood culture (BC) isolates of coagulase-negative staphylococci other than Staphylococcus epidermidis (NonSe-CoNS) for clinical relevance at a tertiary care hospital in Germany from January 2011 to September 2015. METHODS: Clinical data were correlated to microbiological results based on medical records. Infection was considered likely if (1) no other infection and (2) two or more isolates of the same species were present and (3) symptoms ameliorated after therapy...
September 22, 2016: Infection
https://www.readbyqxmd.com/read/27629897/disk-diffusion-testing-for-the-detection-of-methicillin-resistant-staphylococci-does-moxalactam-improve-upon-cefoxitin
#13
Marie Bonjean, Elisabeth Hodille, Oana Dumitrescu, Céline Dupieux, Christina Nkoud Mongo, Camille Allam, Mathilde Beghin, Mickael Paris, Ophelie Borrel, Hubert Chardon, Fréderic Laurent, Jean-Philippe Rasigade, Gerard Lina
Disk diffusion testing is widely used to detect methicillin resistance in staphylococci, and cefoxitin is currently considered the best marker for mecA-mediated methicillin resistance. In low-inoculum diffusion testing (colony suspension at 10(6) CFU/mL), though the addition of moxalactam in combination with cefoxitin has been reported to improve on cefoxitin alone for the detection of methicillin hetero-resistant staphylococci. However, moxalactam is absent from EUCAST and CLSI guidelines, which use high inoculum diffusion testing (colony suspension at 10(8) CFU/mL), calling into question the potential interest of including moxalactam in their recommendations...
September 14, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27609028/staphylococcus-lugdunensis-a-serious-pathogen-in-periprosthetic-joint-infections-comparison-to-staphylococcus-aureus-and-staphylococcus-epidermidis
#14
J Lourtet-Hascoët, A Bicart-See, M P Félicé, G Giordano, E Bonnet
OBJECTIVES: The aim of this study was to assess the characteristics of periprosthetic joint infection (PJI) due to Staphylococcus lugdunensis and to compare these to the characteristics of PJI due to Staphylococcus aureus and Staphylococcus epidermidis. METHODS: A retrospective multicentre study including all consecutive cases of S. lugdunensis PJI (2000-2014) was performed. Eighty-eight cases of staphylococcal PJI were recorded: 28 due to S. lugdunensis, 30 to S...
September 5, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27598130/antimicrobial-resistance-profile-of-planktonic-and-biofilm-cells-of-staphylococcus-aureus-and-coagulase-negative-staphylococci
#15
Adilson de Oliveira, Valéria Cataneli Pereira, Luiza Pinheiro, Danilo Flávio Moraes Riboli, Katheryne Benini Martins, Maria de Lourdes Ribeiro de Souza da Cunha
The objective of the present study was to determine the antimicrobial resistance profile of planktonic and biofilm cells of Staphylococcus aureus and coagulase-negative staphylococci (CoNS). Two hundred Staphylococcus spp. strains were studied, including 50 S. aureus and 150 CoNS strains (50 S. epidermidis, 20 S. haemolyticus, 20 S. warneri, 20 S. hominis, 20 S. lugdunensis, and 20 S. saprophyticus). Biofilm formation was investigated by adherence to polystyrene plates. Positive strains were submitted to the broth microdilution method to determine the minimum inhibitory concentration (MIC) for planktonic and biofilm cells and the minimal bactericidal concentration for biofilm cells (MBCB)...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27585401/truncated-autoinducing-peptides-as-antagonists-of-staphylococcus-lugdunensis-quorum-sensing
#16
Christopher P Gordon, Shondra D Olson, Jessica L Lister, Jeffrey S Kavanaugh, Alexander R Horswill
Competitive quorum sensing (QS) antagonism offers a novel strategy for attenuating current multidrug resistant staphylococcal infections. To this end, a series of 10 truncated analogues based on the parent autoinducing peptides (AIPs) of Staphylococcus lugdunensis (groups I and II) and Staphylococcus epidermidis (groups I-III) were sequentially assessed against a newly developed Staphylococcus lugdunensis group I QS reporter strain. The truncated analogues based upon Staphylococcus lugdunensis AIP-1 (1) and AIP-2 (2) displayed respective IC50 values of 0...
October 13, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27575058/competing-for-iron-duplication-and-amplification-of-the-isd-locus-in-staphylococcus-lugdunensis-hku09-01-provides-a-competitive-advantage-to-overcome-nutritional-limitation
#17
Simon Heilbronner, Ian R Monk, Jeremy R Brozyna, David E Heinrichs, Eric P Skaar, Andreas Peschel, Timothy J Foster
Staphylococcus lugdunensis is a coagulase negative bacterial pathogen that is particularly associated with severe cases of infectious endocarditis. Unique amongst the coagulase-negative staphylococci, S. lugdunensis harbors an iron regulated surface determinant locus (isd). This locus facilitates the acquisition of heme as a source of nutrient iron during infection and allows iron limitation caused by "nutritional immunity" to be overcome. The isd locus is duplicated in S. lugdunensis HKU09-01 and we show here that the duplication is intrinsically unstable and undergoes accordion-like amplification and segregation leading to extensive isd copy number variation...
August 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27555044/staphylococcus-lugdunensis-an-unusual-and-aggressive-cause-of-infective-endocarditis
#18
Eduardo Josué Flores Umanzor, Rodolfo San Antonio, Gustavo Jimenez Britez, Guillem Caldentey
No abstract text is available yet for this article.
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27546604/corrigendum-to-carriage-niches-and-molecular-epidemiology-of-staphylococcus-lugdunensis-and-methicillin-resistant-s-lugdunensis-among-patients-undergoing-long-term-renal-replacement-therapy-diagnostic-microbiology-and-infectious-disease-81-2015-141-144
#19
Pak-Leung Ho, Sammy Man-Him Leung, Kin-Hung Chow, Cindy Wing-Sze Tse, Vincent Chi-Chung Cheng, Herman Tse, Siu-Ka Mak, Wai-Kei Lo
No abstract text is available yet for this article.
September 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27503649/emergence-of-iles2-carrying-multidrug-resistant-plasmids-in-staphylococcus-lugdunensis
#20
Pak-Leung Ho, Melissa Chun-Jiao Liu, Kin-Hung Chow, Cindy Wing-Sze Tse, Wai-U Lo, Siu-Ka Mak, Wai-Kei Lo
Of 137 Staphylococcus lugdunensis isolates collected from two nephrology centers in Hong Kong, 10 (7.3%) and 3 (2.2%) isolates had high-level and low-level mupirocin resistance, respectively. Isolates with high-level resistance contained the plasmid-mediated ileS2 gene, while isolates with low-level resistance contained the mutation V588F within the chromosomal ileS gene. All but one of the ileS2-positive isolates belong to the predominating clone HKU1. Plasmids carrying the ileS2 gene were mosaic and also cocarry multiple other resistance determinants...
October 2016: Antimicrobial Agents and Chemotherapy
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