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staph lugdunensis

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https://www.readbyqxmd.com/read/29904997/the-surreptitious-survival-of-the-emerging-pathogen-staphylococcus-lugdunensis-within-macrophages-as-an-immune-evasion-strategy
#1
Ronald S Flannagan, David W Watson, Bas G Surewaard, Paul Kubes, David E Heinrichs
Staphylococcus lugdunensis is a commensal bacterium that can cause serious infection suggesting an ability to circumvent aspects of host immunity. We demonstrate here that macrophages fail to kill ingested S. lugdunensis and the bacteria persist for extended periods, without replicating, within mature LAMP-1-positive phagolysosomes. Phagocytosed S. lugdunensis also do not intoxicate host cells in contrast to S. aureus. Optimal survival of S. lugdunensis requires O-acetylated peptidoglycan since an oatA mutant, which is more sensitive to killing by lysozyme than WT, survived to a lesser extent in macrophages...
June 14, 2018: Cellular Microbiology
https://www.readbyqxmd.com/read/29900089/staphylococcus-lugdunensis-endocarditis-and-cerebrovascular-accident-a-systemic-review-of-risk-factors-and-clinical-outcome
#2
REVIEW
Htoo Kyaw, Felix Raju, Atif Z Shaikh, Aung Naing Lin, Aye T Lin, Joseph Abboud, Sarath Reddy
Infective endocarditis (IE) secondary to Staphylococcus lugdunensis has been increasingly recognized since 1988. IE-related thromboembolism represents an associated complication of the disease and carries a dismal prognosis. However, the incidence of cerebrovascular accident secondary to S. lugdunensis IE is relatively uncommon and its treatment has not been clearly elucidated yet. We performed an extensive literature search using Pubmed, Medline, Scopus, and Google Scholar to identify the articles using the following keywords: 'Staphylococcus lugdunensis', 'infective endocarditis', 'stroke', and 'cerebrovascular accident...
April 12, 2018: Curēus
https://www.readbyqxmd.com/read/29897142/clinical-and-microbiological-properties-of-staphylococcus-lugdunensis-skin-infections
#3
Hiba Zaaroura, Yuval Geffen, Reuven Bergman, Emily Avitan-Hersh
Staphylococcus lugdunensis is an emerging pathogen in skin and soft tissue infections that was previously considered a commensal. The aim of this study was to elucidate the characteristics of skin infections by S. lugdunensis and its appropriate management, in a tertiary referral medical center. The clinical files, bacterial cultures and histopathology reports of all S. lugdunensis isolates from skin infections over a period of 8 years (September 2009-September 2017) were reviewed. S. lugdunensis was isolated from 29 patients with skin infections, aged 7-89 years (mean 33...
June 13, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29882122/coagulase-negative-staphylococcus-skin-and-soft-tissue-infections
#4
REVIEW
Nicola E Natsis, Philip R Cohen
Coagulase-negative staphylococcus organisms may be normal flora of human skin, however these bacteria can also be pathogens in skin and soft tissue infections. A summary of skin and soft tissue infections caused by coagulase-negative staphylococcus species is provided in this review. We conducted a search of the PubMed database using the following terms: abscess, auricularis, biofilm, capitis, cellulitis, coagulase, contaminant, cyst, draining, epidermidis, felon, folliculitis, furuncle, haemolyticus, hominis, indolent, infection, lugdunensis, mecA, microbiome, negative, osteomyelitis, paronychia, saprophyticus, skin, simulans, sinus, soft, staphylococcus, systemic, tissue, virulence, virulent, and vulvar...
June 7, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29880073/species-and-antimicrobial-susceptibility-testing-of-coagulase-negative-staphylococci-in-periprosthetic-joint-infections
#5
J Lourtet-Hascoët, M P Félicé, A Bicart-See, A Bouige, G Giordano, E Bonnet
The objective was to evaluate the distribution of coagulase-negative staphylococci (CNS) involved in periprosthetic-joint infections (PJIs) and to describe their susceptibility profile to antibiotics. We conducted a multicentre retrospective study in France, including 215 CNS PJIs between 2011 and 2015. CNS PJIs involved knees in 54% of the cases, hips in 39%, other sites in 7%. The distribution of the 215 strains was: Staphylococcus epidermidis 129 (60%), Staphylococcus capitis 24 (11%), Staphylococcus lugdunensis 21 (10%), Staphylococcus warneri 8 (4%), Staphylococcus hominis 7 (3%), Staphylococcus haemolyticus 7 (3%)...
June 8, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29848564/delafloxacin-in-vitro-broth-microdilution-and-disk-diffusion-antimicrobial-susceptibility-testing-guidelines-susceptibility-breakpoint-criteria-and-quality-control-ranges-for-an-expanded-spectrum-anionic-fluoroquinolone
#6
M A Pfaller, R K Flamm, S P McCurdy, C M Pillar, D Shortridge, R N Jones
Delafloxacin, a recently approved anionic fluoroquinolone, was tested within an international resistance surveillance program. The in vitro susceptibilities of 7,914 indicated pathogens causing acute bacterial skin and skin structure infections (ABSSSI) were determined using Clinical and Laboratory Standards Institute (CLSI) broth microdilution MIC testing methods. The United States Food and Drug Administration (U.S. FDA) susceptibility testing breakpoints and quality control ranges for routine broth microdilution and disk diffusion methods were confirmed...
May 30, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29701398/trauma-an-unusual-cause-of-endocarditis
#7
Ana Braga, Marta Marques, Miguel Abecacis, José Pedro Neves
INTRODUCTION: Infective endocarditis (IE) remains a dangerous condition with considerable associated mortality. Usual risk factors for IE include the presence of a prosthetic heart valve, structural or congenital heart disease, intravenous drug use, and a recent history of invasive procedures. METHODS: The authors describe the case report of a patient with IE having trauma as an unusual risk factor. RESULTS: A 33-year old male patient was referred to our department due to infective endocarditis...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29614037/new-parameters-to-quantitatively-express-the-invasiveness-of-bacterial-strains-from-implant-related-orthopaedic-infections-into-osteoblast-cells
#8
Davide Campoccia, Lucio Montanaro, Stefano Ravaioli, Ilaria Cangini, Francesca Testoni, Livia Visai, Carla Renata Arciola
Complete eradication of bacterial infections is often a challenging task, especially in presence of prosthetic devices. Invasion of non-phagocytic host cells appears to be a critical mechanism of microbial persistence in host tissues. Hidden within host cells, bacteria elude host defences and antibiotic treatments that are intracellularly inactive. The intracellular invasiveness of bacteria is generally measured by conventional gentamicin protection assays. The efficiency of invasion, however, markedly differs across bacterial species and adjustments to the titre of the microbial inocula used in the assays are often needed to enumerate intracellular bacteria...
April 3, 2018: Materials
https://www.readbyqxmd.com/read/29559491/common-variable-immunodeficiency-presenting-in-a-man-with-recurrent-pneumonia-caused-by-staphylococcus-lugdunensis
#9
Nkechi Chiugo Mbaebie, Sylvia Vania Alarcon Velasco, Jason Touhey
Common variable immunodeficiency (CVID) refers to a group of disorders where differentiation and maturation of B cells into plasma cells are affected, leading to decreased or defective immunoglobulin production and subsequent immunodeficiency. Symptoms may present at any age between 5 and 72 years, although more severe forms often manifest earlier in life. Milder forms may not be detected. We present an intriguing case of a 69-year-old man presenting with recurrent pneumonia caused by a rare organism Staphylococcus lugdunensis , eventually determined to be caused by CVID...
March 20, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29469751/staphylococcus-lugdunensis-cutaneous-infection-with-sporotrichoid-distribution
#10
Nicola Di Meo, Sara Trevisini, Cecilia Noal, Katiuscia Nan, Giusto Trevisan
We report the occurrence of Staphylococcus lugdunensis cutaneous infection with sporotrichoid distribution of the left lower limb of a 60-year-old man. Recent studies have confirmed that Staphylococcus lugdunensis is a significant pathogen in causing skin and soft tissue infections that usually manifest in abscesses, surgical wound infections, and cellulitis. It used to be considered a skin commensal bacteria, but if unrecognized it can lead to  fulminant endocarditis, meningitis, skin abscesses, peritonitis, and spondylodiscitis...
August 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29468213/acute-onset-endophthalmitis-caused-by-staphylococcus-lugdunensis
#11
Robert B Garoon, Darlene Miller, Harry W Flynn
Purpose: To report a series of patients with acute-onset bacterial endophthalmitis caused by culture proven Staphylococcus lugdunensis , and to characterize clinical outcomes and microbiologic susceptibilities of this organism. Observations: The study included six eyes of 6 patients. The etiologies included cataract surgery (3), open globe injury (2), and intravitreal injection (1). Isolates of S. lugdunensis demonstrated sensitivity to vancomycin in all cases reported...
March 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29407401/antibiotic-susceptibility-of-methicillin-resistant-staphylococci-mrs-of-food-origin-a-comparison-of-agar-disc-diffusion-method-and-a-commercially-available-miniaturized-test
#12
Laura Buzón-Durán, Rosa Capita, Carlos Alonso-Calleja
Methicillin-resistant staphylococci (MRS) are a major concern to public and animal health. Thirty MRS (Staphylococcus aureus, S. cohnii, S. epidermidis, S. haemolyticus, S. hominis, S. lentus, S. lugdunensis, S. sciuri, and S. xylosus) isolates from meat and poultry preparations were tested for antimicrobial susceptibility to 11 antimicrobials (belonging to seven different categories) of clinical significance using both the standard agar disc diffusion method and a commercially available miniaturized system (Sensi Test Gram-positive)...
June 2018: Food Microbiology
https://www.readbyqxmd.com/read/29325360/-update-on-staphylococcus-lugdunensis-infective-endocarditis
#13
(no author information available yet)
No abstract text is available yet for this article.
December 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29187565/evaluation-of-oxacillin-and-cefoxitin-disk-diffusion-and-mic-breakpoints-established-by-the-clinical-and-laboratory-standards-institute-for-detection-of-meca-mediated-oxacillin-resistance-in-staphylococcus-schleiferi
#14
H K Huse, S A Miller, S Chandrasekaran, J A Hindler, S D Lawhon, D A Bemis, L F Westblade, R M Humphries
Staphylococcus schleiferi is a beta-hemolytic, coagulase-variable colonizer of small animals that can cause opportunistic infections in humans. In veterinary isolates, the rate of mecA -mediated oxacillin resistance is significant, with reported resistance rates of >39%. The goal of this study was to evaluate oxacillin and cefoxitin disk diffusion (DD) and MIC breakpoints for detection of mecA -mediated oxacillin resistance in 52 human and 38 veterinary isolates of S. schleiferi Isolates were tested on multiple brands of commercial media and according to Clinical and Laboratory Standards Institute (CLSI) methods...
February 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29063699/characterization-of-aicar-transformylase-imp-cyclohydrolase-atic-from-staphylococcus-lugdunensis
#15
Preeti Verma, Bibekananda Kar, Ritu Varshney, Partha Roy, Ashwani K Sharma
The 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase/inosine monophosphate (IMP) cyclohydrolase (ATIC) catalyzes final two steps of purine nucleotide de novo biosynthetic pathway. This study reports the characterization of ATIC from Staphylococcus lugdunensis (SlugATIC). Apart from kinetic analysis and a detailed biophysical characterization of SlugATIC, the role of ATIC in cell proliferation has been demonstrated for the first time. The purified recombinant SlugATIC and its truncated domains exist mainly in dimeric form was revealed in gel-filtration and glutaraldehyde cross-linking studies...
December 2017: FEBS Journal
https://www.readbyqxmd.com/read/29035784/concentrations-of-staphylococcus-species-in-indoor-air-as-associated-with-other-bacteria-season-relative-humidity-air-change-rate-and-s-aureus-positive-occupants
#16
Anne Mette Madsen, Saloomeh Moslehi-Jenabian, Md Zohorul Islam, Mika Frankel, Michal Spilak, Margit W Frederiksen
The aim of this study was to obtain knowledge about concentrations of Staphylococcus aureus, MRSA (methicillin-resistant S. aureus), and other Staphylococcus species in indoor air in Greater Copenhagen and about factors affecting the concentrations. The effects of season, temperature, relative humidity, air change rate (ACR), other bacterial genera, area per occupant, and presence of S. aureus-positive occupants were studied. In samples from 67 living rooms, S. hominis, S. warneri, S. epidermidis, and S. capitis were found in 13-25%; S...
January 2018: Environmental Research
https://www.readbyqxmd.com/read/29022273/staphylococcus-lugdunensis-infections-of-the-skin-and-soft-tissue-a-case-series-and-review
#17
Lucas A Heldt Manica, Philip R Cohen
INTRODUCTION: Staphylococcus lugdunensis (S. lugdunensis) is a coagulase-negative, Gram-positive bacterium that can be isolated as a component of normal skin flora in humans. However, more recently, it has also been documented as a culprit in skin and soft tissue infections. We describe the clinical features of five individuals with S. lugdunensis-associated skin infections. We review the characteristics of other patients that were previously described with this organism as the causative agent of skin infection...
December 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28962025/characterization-of-two-novel-variants-of-staphylococcal-cassette-chromosome-mec-elements-in-oxacillin-resistant-staphylococcus-lugdunensis
#18
Shih-Cheng Chang, Ming-Hsun Lee, Chun-Fu Yeh, Tsui-Ping Liu, Jung-Fu Lin, Cheng-Mao Ho, Jang-Jih Lu
Objectives: Staphylococcus lugdunensis, a species of CoNS, has become an important hospital pathogen because of increasing resistance to β-lactam antibiotics such as methicillin and oxacillin. Methicillin resistance is mainly due to the acquisition of the staphylococcal cassette chromosome (SCC) mec (SCCmec). Little is known about the structure of SCCmec in methicillin- or oxacillin-resistant CoNS. Methods: WGS was performed to determine the structure of SCCmec elements of two clinical S...
December 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28943172/staphylococcus-lugdunensis-small-colony-variant-conversion-resulting-in-chronic-prosthetic-joint-infection
#19
X Argemi, S Dahyot, J Lebeurre, Y Hansmann, C Ronde Oustau, G Prévost
No abstract text is available yet for this article.
November 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/28937308/particularities-of-staphylococcus-lugdunensis-in-orthopaedic-infections
#20
LETTER
Morad Mohamad, Ilker Uçkay, Didier Hannouche, Hermès Miozzari
No abstract text is available yet for this article.
March 2018: Infectious Diseases
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