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staph lugdunensis

Yuji Watanabe, Nozomi Oikawa, Maya Hariu, Ryota Fuke, Masafumi Seki
Procalcitonin (PCT) and C-reactive protein serve as biomarkers of infection in patients with sepsis/bacteremia. The present study assessed the clinical characteristics of 280 patients with suspected sepsis who were admitted to Tohoku Medical and Pharmaceutical University Hospital between January 2012 and December 2013. Among the patients, 133 and 147 were positive and negative for PCT, respectively. Patients who were PCT positive were older and more frequently male, had reduced levels of platelets and albumin, and increased levels of aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, creatinine, and C-reactive protein...
2016: International Journal of General Medicine
Marie-Paule Guillaume, François Dubos, François Godart
We report the case of a 2-year-old boy with severe Langerhans cell histiocytosis who had tricuspid endocarditis caused by Staphylococcus lugdunensis and required surgery despite appropriate antimicrobial therapy. Through this case and literature review of endocarditis caused by S. lugdunensis in children, we highlight pitfalls and mistakes to be avoided in the management of this rare but serious infection.
October 17, 2016: Cardiology in the Young
Amballa Chaitanyakumar, M Anbalagan
Enzymes find their applications in various industries, due to their error free conversion of substrate into product. Tannase is an enzyme used by various industries for degradation of tannin. Biochemical characterization of a specific enzyme from one organism to other is one of the ways to search for enzymes with better traits for industrial applications. Here, tannase encoding gene from Staphylococcus lugdunensis was cloned and suitability of the enzyme in various conditions was analysed to find its application in various industry...
December 2016: AMB Express
Ana M Misic, Christine L Cain, Daniel O Morris, Shelley C Rankin, Daniel P Beiting
Staphylococcus species are a leading cause of skin and soft tissue infections in humans and animals, and the antibiotics used to treat these infections are often the same. Methicillin- and multidrug-resistant staphylococcal infections are becoming more common in human and veterinary medicine. From a "One Health" perspective, this overlap in antibiotic use and resistance raises concerns over the potential spread of antibiotic resistance genes. Whole-genome sequencing and comparative genomics analysis revealed that Staphylococcus species use divergent pathways to synthesize isoprenoids...
September 2016: MSphere
Florian Hitzenbichler, Michaela Simon, Bernd Salzberger, Frank Hanses
PURPOSE: We retrospectively evaluated blood culture (BC) isolates of coagulase-negative staphylococci other than Staphylococcus epidermidis (NonSe-CoNS) for clinical relevance at a tertiary care hospital in Germany from January 2011 to September 2015. METHODS: Clinical data were correlated to microbiological results based on medical records. Infection was considered likely if (1) no other infection and (2) two or more isolates of the same species were present and (3) symptoms ameliorated after therapy...
September 22, 2016: Infection
Marie Bonjean, Elisabeth Hodille, Oana Dumitrescu, Céline Dupieux, Christina Nkoud Mongo, Camille Allam, Mathilde Beghin, Mickael Paris, Ophelie Borrel, Hubert Chardon, Fréderic Laurent, Jean-Philippe Rasigade, Gerard Lina
Disk diffusion testing is widely used to detect methicillin resistance in staphylococci, and cefoxitin is currently considered the best marker for mecA-mediated methicillin resistance. In low-inoculum diffusion testing (colony suspension at 10(6) CFU/mL), though the addition of moxalactam in combination with cefoxitin has been reported to improve on cefoxitin alone for the detection of methicillin hetero-resistant staphylococci. However, moxalactam is absent from EUCAST and CLSI guidelines, which use high inoculum diffusion testing (colony suspension at 10(8) CFU/mL), calling into question the potential interest of including moxalactam in their recommendations...
September 14, 2016: Journal of Clinical Microbiology
J Lourtet-Hascoët, A Bicart-See, M P Félicé, G Giordano, E Bonnet
OBJECTIVES: The aim of this study was to assess the characteristics of periprosthetic joint infection (PJI) due to Staphylococcus lugdunensis and to compare these to the characteristics of PJI due to Staphylococcus aureus and Staphylococcus epidermidis. METHODS: A retrospective multicentre study including all consecutive cases of S. lugdunensis PJI (2000-2014) was performed. Eighty-eight cases of staphylococcal PJI were recorded: 28 due to S. lugdunensis, 30 to S...
September 5, 2016: International Journal of Infectious Diseases: IJID
Adilson de Oliveira, Valéria Cataneli Pereira, Luiza Pinheiro, Danilo Flávio Moraes Riboli, Katheryne Benini Martins, Maria de Lourdes Ribeiro de Souza da Cunha
The objective of the present study was to determine the antimicrobial resistance profile of planktonic and biofilm cells of Staphylococcus aureus and coagulase-negative staphylococci (CoNS). Two hundred Staphylococcus spp. strains were studied, including 50 S. aureus and 150 CoNS strains (50 S. epidermidis, 20 S. haemolyticus, 20 S. warneri, 20 S. hominis, 20 S. lugdunensis, and 20 S. saprophyticus). Biofilm formation was investigated by adherence to polystyrene plates. Positive strains were submitted to the broth microdilution method to determine the minimum inhibitory concentration (MIC) for planktonic and biofilm cells and the minimal bactericidal concentration for biofilm cells (MBCB)...
2016: International Journal of Molecular Sciences
Christopher P Gordon, Shondra D Olson, Jessica L Lister, Jeffrey S Kavanaugh, Alexander R Horswill
Competitive quorum sensing (QS) antagonism offers a novel strategy for attenuating current multidrug resistant staphylococcal infections. To this end, a series of 10 truncated analogues based on the parent autoinducing peptides (AIPs) of Staphylococcus lugdunensis (groups I and II) and Staphylococcus epidermidis (groups I-III) were sequentially assessed against a newly developed Staphylococcus lugdunensis group I QS reporter strain. The truncated analogues based upon Staphylococcus lugdunensis AIP-1 (1) and AIP-2 (2) displayed respective IC50 values of 0...
October 13, 2016: Journal of Medicinal Chemistry
Simon Heilbronner, Ian R Monk, Jeremy R Brozyna, David E Heinrichs, Eric P Skaar, Andreas Peschel, Timothy J Foster
Staphylococcus lugdunensis is a coagulase negative bacterial pathogen that is particularly associated with severe cases of infectious endocarditis. Unique amongst the coagulase-negative staphylococci, S. lugdunensis harbors an iron regulated surface determinant locus (isd). This locus facilitates the acquisition of heme as a source of nutrient iron during infection and allows iron limitation caused by "nutritional immunity" to be overcome. The isd locus is duplicated in S. lugdunensis HKU09-01 and we show here that the duplication is intrinsically unstable and undergoes accordion-like amplification and segregation leading to extensive isd copy number variation...
August 2016: PLoS Genetics
Eduardo Josué Flores Umanzor, Rodolfo San Antonio, Gustavo Jimenez Britez, Guillem Caldentey
No abstract text is available yet for this article.
2016: BMJ Case Reports
Pak-Leung Ho, Sammy Man-Him Leung, Kin-Hung Chow, Cindy Wing-Sze Tse, Vincent Chi-Chung Cheng, Herman Tse, Siu-Ka Mak, Wai-Kei Lo
No abstract text is available yet for this article.
September 2016: Diagnostic Microbiology and Infectious Disease
Pak-Leung Ho, Melissa Chun-Jiao Liu, Kin-Hung Chow, Cindy Wing-Sze Tse, Wai-U Lo, Siu-Ka Mak, Wai-Kei Lo
Of 137 Staphylococcus lugdunensis isolates collected from two nephrology centers in Hong Kong, 10 (7.3%) and 3 (2.2%) isolates had high-level and low-level mupirocin resistance, respectively. Isolates with high-level resistance contained the plasmid-mediated ileS2 gene, while isolates with low-level resistance contained the mutation V588F within the chromosomal ileS gene. All but one of the ileS2-positive isolates belong to the predominating clone HKU1. Plasmids carrying the ileS2 gene were mosaic and also cocarry multiple other resistance determinants...
October 2016: Antimicrobial Agents and Chemotherapy
Alexander Zipperer, Martin C Konnerth, Claudia Laux, Anne Berscheid, Daniela Janek, Christopher Weidenmaier, Marc Burian, Nadine A Schilling, Christoph Slavetinsky, Matthias Marschal, Matthias Willmann, Hubert Kalbacher, Birgit Schittek, Heike Brötz-Oesterhelt, Stephanie Grond, Andreas Peschel, Bernhard Krismer
The vast majority of systemic bacterial infections are caused by facultative, often antibiotic-resistant, pathogens colonizing human body surfaces. Nasal carriage of Staphylococcus aureus predisposes to invasive infection, but the mechanisms that permit or interfere with pathogen colonization are largely unknown. Whereas soil microbes are known to compete by production of antibiotics, such processes have rarely been reported for human microbiota. We show that nasal Staphylococcus lugdunensis strains produce lugdunin, a novel thiazolidine-containing cyclic peptide antibiotic that prohibits colonization by S...
July 28, 2016: Nature
Chun-Fu Yeh, Shih-Cheng Chang, Chun-Wen Cheng, Jung-Fu Lin, Tsui-Ping Liu, Jang-Jih Lu
Staphylococcus lugdunensis is a major cause of aggressive endocarditis, but it is also responsible for a broad spectrum of infections. The differences in clinical and molecular characteristics between community-associated (CA) and health care-associated (HA) S. lugdunensis infections have remained unclear. We performed a retrospective study of S. lugdunensis infections between 2003 and 2014 to compare the clinical and molecular characteristics of CA and HA isolates. We collected 129 S. lugdunensis isolates in total: 81 (62...
August 2016: Journal of Clinical Microbiology
Alexandros C Katoulis, Dimitra Koumaki, Aikaterini I Liakou, Georgia Vrioni, Vasiliki Koumaki, Dimitra Kontogiorgi, Korina Tzima, Athanasios Tsakris, Dimitris Rigopoulos
INTRODUCTION: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of unclear etiology. The role of bacteria in the pathogenesis of disease remains controversial. MATERIALS AND METHODS: Specimens were obtained from 22 HS patients by direct percutaneous needle aspiration. The collected material was cultured in aerobic and anaerobic conditions, and sensitivity tests were performed. RESULTS: Of the 22 patients, 32% were culture negative and 68% were culture positive...
September 2015: Skin Appendage Disorders
María Tamargo Delpón, Pablo Demelo-Rodríguez, Juan Carlos Cano Ballesteros, Laura Vela de la Cruz
Staphylococcus lugdunensis is a coagulase-negative staphylococcus of growing importance and atypical behavior. The infections caused by this microorganism are becoming more frequent, having a broader spectrum. Psoas abscesses caused by this germ are rare, with few cases reported in the literature. In this work, we present a case of a psoas abscess caused by S. lugdunensis in a patient suffering from diabetes mellitus and rheumatoid arthritis, which was treated with intravenous cloxacillin with a good outcome...
April 2016: Revista Argentina de Microbiología
Daniel E Stone, Karen M Swarer, Benjamin J Barenberg, Dena E OʼLeary
BACKGROUND: We present a case of Staphylococcus lugdunensis colonization of a midurethral sling. Staphylococcus lugdunensis is a common skin colonizer and has been isolated in cases of implanted prosthetic devices. CASE: A 52-year-old female presented with suprapubic pain and recurrent urinary tract infections with S. lugdunensis starting 3 months after a retropubic sling procedure. After several months of continued pain and a suspicion of a mesh-related infection, the sling was removed...
May 2016: Female Pelvic Medicine & Reconstructive Surgery
Mounir Khafaga, Karl-Patrik Kresoja, Berndt Urlesberger, Igor Knez, Philipp Klaritsch, David Benjamin Lumenta, Robert Krause, Dirk von Lewinski
Background. Infective endocarditis is associated with considerable morbidity and mortality. Guidelines addressing prophylaxis and management of infective endocarditis do not extensively deal with concomitant pregnancy, and case reports on infective endocarditis are scarce. This is the first published report of infective endocarditis by Staphylococcus lugdunensis in a pregnant woman. Case Presentation. We report a single case of a 35-year-old woman in her 24th week of pregnancy who was admitted to our intensive care unit with fever and suspected infectious endocarditis...
2016: Case Reports in Obstetrics and Gynecology
Helio S Sader, David J Farrell, Robert K Flamm, Jennifer M Streit, Rodrigo E Mendes, Ronald N Jones
A total of 1593 coagulase-negative staphylococci (CoNS) considered clinically significant were collected from 71 US medical centers in 2013-2014 and tested for susceptibility by CLSI broth microdilution methods. Species identification was performed by matrix-assisted laser desorption ionization-time-of-flight mass spectrometry. Overall, 59.7% of isolates were oxacillin resistant (MRCoNS). Ceftaroline (MIC50/90, 0.25/0.5μg/mL) inhibited 99.2% of CoNS at ≤1μg/mL (susceptible breakpoint for Staphylococcus aureus), including 98...
May 2016: Diagnostic Microbiology and Infectious Disease
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