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https://www.readbyqxmd.com/read/27926660/radioembolization-induced-liver-disease-a-systematic-review
#1
Manon N G J A Braat, Karel J van Erpecum, Bernard A Zonnenberg, Maurice A J van den Bosch, Marnix G E H Lam
Radioembolization (RE) is a relatively novel treatment modality for primary and secondary hepatic malignancies. Microspheres embedded with a β-emitting radioisotope are injected into the hepatic artery, resulting in microsphere deposition in the tumor arterioles and normal portal triads. Microsphere deposition in nontumorous parenchyma can result in radiation-induced liver injury, with lethal RE-induced liver disease (REILD) at the outer end of the spectrum. The primary aim of this study was to evaluate RE-related hepatotoxicity and present an overview of the currently applied definitions and clinically relevant characteristics of REILD...
December 6, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27925685/in-vitro-characterization-of-synthoplate-%C3%A2-synthetic-platelet-technology-and-its-in-vivo-evaluation-in-severely-thrombocytopenic-mice
#2
Meenal Shukla, Ujjal D S Sekhon, Venkaiah Betapudi, Wei Li, DaShawn A Hickman, Christa L Pawlowski, Mitchell R Dyer, Matthew D Neal, Keith R McCrae, Anirban Sen Gupta
BACKGROUND: Platelet transfusion applications face severe challenges due to the limited availability and portability, high risk of contamination and short shelf-life of platelets. Therefore there is significant interest in synthetic platelet substitutes that can render hemostasis while avoiding these issues. Platelets promote hemostasis by injury site-selective adhesion and aggregation, and propagation of coagulation reactions on their membrane. Based on these mechanisms, we have developed a synthetic platelet technology (SynthoPlate(™) ) that integrates platelet-mimetic site-selective 'adhesion' and 'aggregation' functionalities via heteromultivalent surface-decoration of lipid vesicles with Von Willebrand Factor-binding, collagen-binding and active platelet integrin GPIIb-IIIa-binding peptides...
December 7, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27925556/assessing-and-documenting-fluid-balance
#3
Sarah Pinnington, Sarah Ingleby, Prasanna Hanumapura, Deryn Waring
Concerns about inadequate patient hydration and suboptimal monitoring of fluid balance have been documented in recent reports. The Fluid Balance Improvement Project at Central Manchester University Hospitals NHS Foundation Trust was undertaken to identify risk factors influencing hydration and to implement a revised process to manage these risks, resulting in the development of a hydration pathway. This new approach to monitoring patient hydration, together with staff education and support, has resulted in improved compliance with fluid balance monitoring standards, as well as significant improvements in identifying patients at risk of dehydration, and an increase in patients with acute kidney injury commencing appropriate fluid balance monitoring...
December 7, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27925118/alcohol-abuse-and-involvement-in-traffic-accidents-in-the-brazilian-population-2013
#4
Giseli Nogueira Damacena, Deborah Carvalho Malta, Cristiano Siqueira Boccolini, Paulo Roberto Borges de Souza, Wanessa da Silva de Almeida, Lucas Sisinno Ribeiro, Célia Landmann Szwarcwald
Abstract This article aims to analyze alcohol abuse and frequent consumption according to sociodemographic characteristics and investigate the risk of greater involvement in traffic accidents, using data from the National Health Survey (PNS), 2013, Brazil. Events investigated were alcohol abuse and frequent consumption and if the individual was involved in a traffic accident and sustained an injury in the last 12 months. We investigated both events according to sociodemographic characteristics and assessed the association among them through multivariate logistic regression...
December 2016: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/27924525/a-three-day-consecutive-fingolimod-administration-improves-neurological-functions-and-modulates-multiple-immune-responses-of-cci-mice
#5
Chuang Gao, Yu Qian, Jinhao Huang, Dong Wang, Wanqiang Su, Peng Wang, Linyue Guo, Wei Quan, Shuo An, Jianning Zhang, Rongcai Jiang
Excessive inflammation after traumatic brain injury (TBI) is a major cause of secondary TBI. Though several inflammatory biomarkers have been postulated as the risk factors of TBI, there has not been any comprehensive description of them. Fingolimod, a new kind of immunomodulatory agent which can diminish various kinds of inflammatory responses, has shown additional therapeutic effects in the treatment of intracranial cerebral hematoma (ICH), ischemia, spinal cord injury (SCI), and many other CNS disorders...
December 6, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27924237/an-investigation-of-health-and-safety-measures-in-a-hydroelectric-power-plant
#6
Amevi Acakpovi, Lucky Dzamikumah
BACKGROUND: Occupational risk management is known as a catalyst in generating superior returns for all stakeholders on a sustainable basis. A number of companies in Ghana implemented health and safety measures adopted from international companies to ensure the safety of their employees. However, there exist great threats to employees' safety in these companies. The purpose of this paper is to investigate the level of compliance of Occupational Health and Safety management systems and standards set by international and local legislation in power producing companies in Ghana...
December 2016: Safety and Health At Work
https://www.readbyqxmd.com/read/27924228/allied-health-professionals-and-work-related-musculoskeletal-disorders-a-systematic-review
#7
REVIEW
Sarah P Anderson, Jodi Oakman
Work-related musculoskeletal injuries and disorders (WMSD) are a significant issue in the health care sector. Allied Health professionals (AHP) in this sector are exposed to physical and psychosocial factors associated with increased risk of developing a WMSD. Clarification of relevant hazard and risk factors for AHP is needed to improve understanding and inform WMSD risk management. A systematic analysis of the literature was undertaken to determine prevalence and risk factors for WMSD in AHP. Databases of Ovid MEDLINE, CINAHL (EBSCO), EMBASE and the Cochrane Database of Systematic Reviews were reviewed...
December 2016: Safety and Health At Work
https://www.readbyqxmd.com/read/27924211/circulating-mir-126-and-mir-499-reflect-progression-of-cardiovascular-disease-correlations-with-uric-acid-and-ejection-fraction
#8
Masoud Khanaghaei, Fereshtah Tourkianvalashani, Seyedhossein Hekmatimoghaddam, Nasrin Ghasemi, Mahdi Rahaie, Vahid Khorramshahi, Akhtar Sheikhpour, Zahra Heydari, Fatemeh Pourrajab
BACKGROUND: The aim of this study was to assess plasma levels of endothelium- and heart-associated microRNAs (miRNAs) miR-126 and miR-499, respectively, using quantitative reverse transcriptase polymerase chain reaction. METHODS: A two-step analysis was conducted on 75 patients undergoing off-pomp coronary artery bypass graft (CABG) surgery. Five biomarkers of inflammation and cardiac injury were assessed in addition to the above-mentioned miRNAs. RESULTS: Plasma concentrations of miRNAs were found to be significantly correlated with plasma levels of cardiac troponin I (cTnI) (miR-499, r 0...
January 2016: Heart International
https://www.readbyqxmd.com/read/27924167/reduction-of-falls-and-factors-affecting-falls-a-year-after-total-knee-arthroplasty-in-elderly-patients-with-severe-knee-osteoarthritis
#9
T Tsonga, M Michalopoulou, S Kapetanakis, E Giovannopoulou, P Malliou, G Godolias, P Soucacos
BACKGROUND: Total Knee Arthroplasty (TKA) is a common surgical treatment for severe knee Osteoarthritis (OA), which generally improves pain, physical function, quality of life and possibly fall risk. Fall risk increases for older adults with severe knee OA; however it has not been studied extensively whether this parameter is improved after TKA. OBJECTIVE: To investigate: a) the history and frequency of falls, including mechanism or causes of falls, injuries sustained from falls reported, activity during falling and location of falls and, b) the factors affecting falls, a year after TKA in elderly patients with severe knee OA...
2016: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/27923800/school-shootings-during-2013-2015-in-the-usa
#10
Bindu Kalesan, Kinan Lagast, Marcos Villarreal, Elizabeth Pino, Jeffrey Fagan, Sandro Galea
BACKGROUND: Data on the factors associated with school shootings in the USA are limited. The public conversation has often suggested several factors that may be linked to these events, however with little empirical support. Aiming to fill this gap, we describe the characteristics of school shooting incidents in the USA between 2013 and 2015 and explore whether four factors that represent domains of firearm policy, educational policy and epidemiological risk factors for intentional firearm injuries-background check (BC) policies, per capita mental health expenditures (MHE), K-12 education expenditure (KEE) and urbanicity-were associated with school shootings during this period...
December 6, 2016: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/27923640/the-accumulation-of-brain-injury-leads-to-severe-neuropathological-and-neurobehavioral-changes-after-repetitive-mild-traumatic-brain-injury
#11
Huabin Gao, Zhaoli Han, Ruojing Bai, Shan Huang, Xintong Ge, Fanglian Chen, Ping Lei
Traumatic brain injury (TBI) is a major public health problem with long-term neurobehavioral sequela. The evidences have revealed that TBI is a risk factor for later development of neurodegenerative disease and both the single and repetitive brain injury can lead to the neurodegeneration. But whether the effects of accumulation play an important role in the neurodegenerative disease is still unknown. We utilized the Sprague Dawley (SD) rats to develop the animal models of repetitive mild TBI and single mild TBI in order to detect the neurobehavioral changes...
December 3, 2016: Brain Research
https://www.readbyqxmd.com/read/27923537/using-acute-kidney-injury-severity-and-scoring-systems-to-predict-outcome-in-patients-with-burn-injury
#12
George Kuo, Shih-Yi Yang, Shiow-Shuh Chuang, Pei-Chun Fan, Chih-Hsiang Chang, Yen-Chang Hsiao, Yung-Chang Chen
BACKGROUND/PURPOSE: Acute kidney injury (AKI) is a frequent complication of severe burn injury and is associated with mortality. The definition of AKI was modified by the Kidney Disease Improving Global Outcomes Group in 2012. So far, no study has compared the outcome accuracy of the new AKI staging guidelines with that of the complex score system. Hence, we compared the accuracy of these approaches in predicting mortality. METHODS: This was a post hoc analysis of prospectively collected data from an intensive care burn unit in a tertiary care university hospital...
December 3, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/27923219/nonoperative-versus-operative-treatment-of-displaced-ankle-fractures-in-diabetics
#13
Andrew J Lovy, James Dowdell, Aakash Keswani, Steven Koehler, Jaehon Kim, Steven Weinfeld, David Joseph
BACKGROUND: Diabetes is a risk factor for complications related to displaced ankle fractures. Limited literature exists comparing complication rates in nonoperative versus operative treatment of displaced ankle fractures in diabetics. No study has highlighted the natural history of nonoperative treatment of displaced ankle fractures in diabetics. METHODS: We retrospectively reviewed all adult ankle fractures from September 2011 through December 2014. Inclusion was limited to ambulatory adults (>18 years) with closed, displaced (widened mortise) ankle fractures with diabetes mellitus...
November 14, 2016: Foot & Ankle International
https://www.readbyqxmd.com/read/27922985/video-analysis-of-anterior-cruciate-ligament-acl-injuries-a-systematic-review
#14
Victor R Carlson, Frances T Sheehan, Barry P Boden
BACKGROUND: As the most viable method for investigating in vivo anterior cruciate ligament (ACL) rupture, video analysis is critical for understanding ACL injury mechanisms and advancing preventative training programs. Despite the limited number of published studies involving video analysis, much has been gained through evaluating actual injury scenarios. METHODS: Studies meeting criteria for this systematic review were collected by performing a broad search of the ACL literature with use of variations and combinations of video recordings and ACL injuries...
November 29, 2016: JBJS Reviews
https://www.readbyqxmd.com/read/27921036/acute-kidney-injury-in-asia
#15
REVIEW
Li Yang
BACKGROUND: Acute kidney injury (AKI) is a common disorder and is associated with a high morbidity and mortality worldwide. The diversity of the climate and of the socioeconomic and developmental status in Asia has a great influence on the etiology and presentation of AKI in different regions. In view of the International Society of Nephrology's 0by25 initiative, more and more attention has been paid to AKI in Asian countries. SUMMARY: In this review, we summarize the recent achievements with regard to the prevalence and clinical patterns of AKI in Asian countries...
October 2016: Kidney Diseases
https://www.readbyqxmd.com/read/27921017/factors-impacting-mortality-in-the-pre-hospital-period-after-road-traffic-accidents-in-urban-india
#16
Ananthnarayan Chandrasekharan, Aditya J Nanavati, Sandhya Prabhakar, Subramaniam Prabhakar
BACKGROUND: India currently has the dubious distinction of experiencing the highest number of road traffic accidents in the world. OBJECTIVES: We believe that this study on road traffic accidents may help to identify factors in the pre-hospital setting that may influence mortality rates. PATIENTS AND METHODS: A prospective observational study was carried out in a metro area in India over a period of one year. The study included consecutive patients admitted to the trauma service after road traffic accidents...
July 2016: Trauma Monthly
https://www.readbyqxmd.com/read/27919063/predictors-of-low-back-pain-in-nursing-home-workers-after-implementation-of-a-safe-resident-handling-programme
#17
Judith E Gold, Laura Punnett, Rebecca J Gore
OBJECTIVES: Healthcare workers have high rates of low back pain (LBP) related to handling patients. A large chain of nursing homes experienced reduced biomechanical load, compensation claims and costs following implementation of a safe resident handling programme (SRHP). The aim of this study was to examine whether LBP similarly declined and whether it was associated with relevant self-reported occupational exposures or personal health factors. METHODS: Worker surveys were conducted on multiple occasions beginning with the week of first SRHP introduction (baseline)...
November 10, 2016: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27918997/the-curvilinear-effects-of-sexual-orientation-on-young-adult-substance-use
#18
Jamie E Parnes, Ryan L Rahm-Knigge, Bradley T Conner
Alcohol, tobacco, and marijuana are commonly used by adolescents and linked with harmful health-related outcomes (e.g. injury, dependence). Moreover, heavy episodic (binge) drinking predicts more severe consequences. When examined by sexual orientation, highest rates of substance use have been found among bisexual individuals, with lower use at either end of the spectrum. When examined also by sex, this curvilinear trend is maintained among women but not men. These substance use patterns were identified using group differences (i...
November 18, 2016: Addictive Behaviors
https://www.readbyqxmd.com/read/27918969/isolating-effects-of-moral-injury-and-low-post-deployment-support-within-the-u-s-military
#19
Claire Houtsma, Lauren R Khazem, Bradley A Green, Michael D Anestis
Suicide rates within U.S. military components, particularly the National Guard, are significantly higher than the general population suicide rate. To better understand and prevent suicide within this population, we must identify mechanisms of risk contributing to these discrepancies. One risk factor relevant to military service is moral injury, a term for experiences that violate one's moral beliefs. Using a series of hierarchical multiple regressions, the current study examined the moderating role of post-deployment social support on the association between moral injury (self-transgressions, other-transgressions, and betrayal) and thwarted belongingness among military personnel...
November 28, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27918863/ems-providers-beliefs-regarding-spinal-precautions-for-pediatric-trauma-transport
#20
Cindy D Chang, Remle P Crowe, Melissa A Bentley, Alyssa R Janezic, Julie C Leonard
OBJECTIVE: Describe prehospital Emergency Medical Services (EMS) providers' beliefs regarding spinal precautions for pediatric trauma transport. METHODS: We randomly surveyed nationally certified EMS providers. We assessed providers' beliefs about specific precautions, and preferred precautions given a child's age (0-4 or 5-18 years) and presence of specific cervical spine injury (CSI) risk factors. RESULTS: We received 5,400 responses (17%)...
December 5, 2016: Prehospital Emergency Care
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