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vulval carcinoma

Jason Yap, Danielle O'Neill, Sangeetha Nagenthiran, Christopher Dawson, David Luesley
Squamous cell carcinoma of the vulva is predominantly a disease of the elderly, where the mainstay of treatment is radical surgery. Local vulval recurrence (LVR) is a significant problem for these patients, and the rates of recurrence have not improved over the last three decades. Disappointingly, we still lack an understanding of how LVRs develop and the best approach to prevent and manage the condition. This review discusses recent insights into the key prognostic factors that influence the risk of recurrence, focusing on the role of tumour-adjacent non-neoplastic epithelial disorders, which are thought to play a causative role...
January 12, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
Wiebren A A Tjalma, Vasiliki Siozopoulou, Manon T Huizing
BACKGROUND: Verrucous carcinoma of the vulva is extremely rare. It is a slow growing, low malignant variant of a squamous cell carcinoma with a cauliflower appearance. Women with lichen planus have an increased risk of developing vulval cancer. CASE PRESENTATION: A 79-year-old woman consulted for vulval itching. On clinical examination, a 3-cm large verrucous clitoral cancer in an area of lichen planus was seen. Based on her last clinical examination, the growth was estimated to be 1 cm(2) per month with an invasion depth after 6 months of 5 mm...
January 6, 2017: World Journal of Surgical Oncology
Mayank Gupta
A 68-year-old woman presented with symptoms of bleeding per vaginum. On examination, a growth was seen in the cervix, clinically considered to be squamous cell carcinoma. The growth was confined to the cervix and did not involve the parametria. However, on biopsy it was diagnosed as malignant melanoma. She underwent surgery elsewhere and was advised chemotherapy as these tumours are aggressive; however, she refused chemotherapy. She has been on regular follow-up and has an ongoing survival and disease-free period of more than 5 years...
November 28, 2016: BMJ Case Reports
G A Watson, D Kelly, L Prior, E Stanley, O MacEneaney, T Walsh, C M Kelly
Basal cell carcinoma (BCC) is the most common non-melanomatous skin cancer, typically arising in sun-exposed areas such as the head and neck. Defective signaling through the Hedgehog (HH) signaling pathway forms the molecular basis for BCC. Surgery remains the mainstay of treatment. Basal cell carcinoma of the genital tract is rare as is metastatic BCC. We report a case of metastatic BCC in a young woman with previously resected vulval BCC presenting six years later with inguinal nodal recurrence and multiple lung metastases...
November 2016: Gynecologic Oncology Reports
Jonathan Frost, Linmarie Ludeman, Kathryn Hillaby, Robert Gornall, Gavin Lloyd, Catherine Kendall, Angela C Shore, Nick Stone
Vulval lichen sclerosus (LS) is a common inflammatory condition associated with an increased risk of developing vulval carcinoma. Diagnosis is usually clinical although biopsy is necessary if the diagnosis is uncertain or if there is a failure to respond to adequate initial treatment. Raman spectroscopy has the potential to be applied in vivo for near real time objective non-invasive optical diagnosis, avoiding the need for invasive tissue biopsies. The aim of this study was to evaluate the diagnostic performance of Raman spectroscopy for differentiating LS from other vulval conditions in fresh vulval biopsies...
November 9, 2016: Analyst
Shirley Sze, Ian Richmond, Adam Bickers, Arabinda Saha
Malignant transformation of epidermal cyst is rare, with most cases arising in the head and neck. Here, we report a case of squamous cell carcinoma arising from a longstanding epidermal cyst in the right vulva of a 65-year-old woman. The patient presented with a sudden increase in size of the cyst over 6 weeks to the size of a golf ball. Excisional biopsy and histology indicated moderately differentiated squamous cell carcinoma within an epidermal cyst (FIGO stage IB). Strong p16 immunopositivity was also demonstrated and the potential significance of this is discussed...
November 2016: Journal of Obstetrics and Gynaecology Research
S A Farghaly
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
Georgina Davis, Lyndal Anderson, Selvan Pather
A case of Extramammary Paget's Disease (EMPD) involving the cervix mimicking cervical carcinoma on routine cervical cytology in a 66-year-old woman with a history of recurrent multifocal EMPD involving the vulva, perineum, perianal area, and rectum is reported. The patient had undergone multiple excisions and reconstructions of EMPD, however, had a benign cervical smear history and reported no vaginal bleeding. The conventional papanicolaou smear was reported as concerning for carcinoma with abundant, well preserved material illustrating highly atypical cells with anisonucleosis and dense cytoplasm and focal microacini...
November 2016: Diagnostic Cytopathology
Kate Coffey, Kezia Gaitskell, Valerie Beral, Karen Canfell, Jane Green, Gillian Reeves, Isobel Barnes
BACKGROUND: Vulval cancer predominantly affects postmenopausal women. A smaller proportion of vulval cancers, particularly at older ages, are now thought to be associated with human papillomavirus infection than previously reported, but other risk factors have not been well examined in prospective cohort studies. METHODS: A total of 1.3 million women aged 49-65 years were followed for incident vulval cancer (ICD-10 C51). Adjusted Cox regression models were used to examine the relationship between reproductive and lifestyle factors and risk of vulval cancer...
August 23, 2016: British Journal of Cancer
Josefa E O Vella, Raji Ganesan, Lynn Hirschowitz
Review of pulmonary biopsies received by Birmingham Women's Hospital to identify which gynecologic tumors most commonly metastasize to lung or pleura, and which may first present with pulmonary metastases. We reviewed all pulmonary biopsies over a 14-yr period. There were 25 lung and 9 pleural biopsies, from 33 patients. Twenty-one patients had known gynecologic tumors (1 vulval, 1 cervical, 9 endometrial, 4 uterine mesenchymal, and 6 ovarian). Eighteen of the 21 biopsies had been referred from other hospitals; in 4 cases review lead to an altered diagnosis...
March 2017: International Journal of Gynecological Pathology
Jean Bouquet de Jolinière, F Khomsi, J M Gothuey, L Guillou, A Fadhlaoui, J B Dubuisson, A Feki
Verrucous carcinoma of the vulva is a rare lesion (1). Affecting essentially postmenopausal women, this lesion is a distinct and particular entity in vulval carcinoma classification and its scalability is uncertain and unpredictable. Here, we present a case concerning a 48-year-old patient, without follow-up after a condyloma acuminate of the vulva (large left lip). The origin of this case will be discussed in this article. The treatment decided was only surgical. A review of literature shows the rarity of this lesion of the female genital tract...
2016: Frontiers in Surgery
Henriëtte S de Bruijn, Sander Brooks, Angélique van der Ploeg-van den Heuvel, Timo L M Ten Hagen, Ellen R M de Haas, Dominic J Robinson
BACKGROUND: Light fractionation significantly increases the efficacy of 5-aminolevulinic acid (ALA) based photodynamic therapy (PDT) using the nano-emulsion based gel formulation BF-200. PDT using BF-200 ALA has recently been clinically approved and is under investigation in several phase III trials for the treatment of actinic keratosis. This study is the first to compare BF-200 ALA with ALA in preclinical models. RESULTS: In hairless mouse skin there is no difference in the temporal and spatial distribution of protoporphyrin IX determined by superficial imaging and fluorescence microscopy in frozen sections...
2016: PloS One
Hua Tu, He Huang, Jihong Liu
OBJECTIVE: To systematically review the clinical value of sentinel lymph node biopsy (SLNB) in diagnosis of lymph node metastasis in early-stage squamous cell carcinoma of vulva. METHODS: Cochrane library, biomedical database (EMbase), PubMed, China national knowledge internet (CNKI), Wang Fang database, «Gynecologic Oncology», «National Medical Journal of China» and «Chinese Journal of Obstetrics and Gynecology» were searched for literatures from 1990 to 2014 concerning SLNB application in early-stage vulvar squamous cell carcinoma...
September 1, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Anirudha Rajguru, Alexandra Moulla, Adeyemi Ogunremi, Lakshmi Venkatraman, W Glenn McCluggage, Anitha G Nayar
Microglandular adenosis of the breast is an uncommon lesion which can mimic tubular carcinoma. It is composed of small round tubules lined by a single layer of flat or cuboidal epithelial cells, often with eosinophilic colloid-like material within the lumen. The absence of a myoepithelial cell layer and preservation of basement membrane around the tubules are characteristic features. We report the first case of a vulval "neoplasm" in a 60-yr-old woman showing features identical to microglandular adenosis of the breast except for the presence of an unusual chondromyxoid stroma...
March 2016: International Journal of Gynecological Pathology
M Toby, K Conway, G Sethi, F Lewis
BACKGROUND: Usual or undifferentiated type vulval intraepithelial neoplasia is more common in young women and is usually associated with high-risk human papilloma virus infection. It is associated with the development of basaloid or warty squamous cell carcinoma. Studies have shown that HIV-positive women have an increased risk of VIN and invasive vulval carcinoma but there is a paucity of data about this cohort of women. OBJECTIVE: To describe the clinical features and treatment response of HIV-positive women diagnosed with vulval intraepithelial neoplasia in a specialist vulval dermatology clinic...
October 14, 2015: International Journal of STD & AIDS
Anji Reddy Kallam
An unusual case of Acquired Total vulval synechia due to vulvar Lichen planus is reported in an 18-year-old girl, which is an extremely rare condition. It has a potential for producing extensive scarring and narrowing of introitus resulting in dyspareunia and rarely carcinoma of vulva. Successful surgical management of total vulvar synechiae in patient suffering from Lichen Planus is being reported.
April 2015: Journal of Clinical and Diagnostic Research: JCDR
Shiho Asaka, Akihiko Yoshizawa, Kenji Sano, Hisashi Uhara, Takayuki Honda, Hiroyoshi Ota
We report a case of vulval extramammary Paget disease (EMPD) with dermal invasion showing mucinous carcinoma (MC). An 80-year-old woman presented with vulvar itching and pain. A physical examination showed a pigmented vulvar, perianal erythematous plague, and a subcutaneous nodule in the left major labia. No internal malignancy, such as colorectal or genitourinary carcinoma, was identified in any of the clinical examinations. A histological examination of the resected specimen revealed Pagetoid tumor cells that had spread widely through the epidermis and invaded the dermis forming a solid nest with mucous lake-like MC...
July 2015: International Journal of Gynecological Pathology
Hyun H Han, Daiwon Jun, Bommie F Seo, Suk-Ho Moon, Deuk Y Oh, Sang T Ahn, Jong-Won Rhie
Various skin tumours such as squamous cell carcinoma and extramammary Paget's disease can occur in the vulval area, and reconstruction of the vulval area can be a very challenging task. A retrospective analysis of vulvar reconstruction using the new method 'internal pudendal perforator artery-based gull wing flap' was performed from April 2012 to December 2013. A perforator vessel from the internal pudendal artery was detected with a portable Doppler and marked, and this was the pivot point around which the flap was rotated...
October 2016: International Wound Journal
D Shrestha, K D Bista, M Singh, N Ojha, S Rajbhandari
Genital myiasis is a very rare entity associated with poor personal hygiene, restricted mobility, and immunosuppressed status and ulcerating lesions. With the reported incidence of only 0.7%, only a few cases have been published so far in literature but none from Nepal. Despite such rare occurrence, we present here two such cases which we encountered in an interval of three days; one in an unmarried teenager and another in a postmenopausal lady with fungating ulcerative growth of vulval carcinoma. Both were successfully managed...
May 2014: Journal of Nepal Health Research Council
L W Gustafson, Melina Gade, Jan Blaakær
A woman diagnosed with a recurrent vulval carcinoma after initial treatment with radiochemotherapy is presented. After three additional relapses she was vaccinated with Gardasil. She has had no relapses in her vulvar area for 39 months and an overall progression-free survival of almost 24 months.
December 2014: Clinical Case Reports
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