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mean platelet volume

Sung Phil Chung, Je Sung You
We are pleased that Zeng et al. have taken an interest in our paper. As Zeng et al. pointed out, the mean platelet volume (MPV) is a crucial parameter that reflects platelet size and activation [1]. Recently, MPV has also been highlighted as a critical inflammatory marker in infectious, cardiovascular, and immunological diseases [2-5]. We also recognize that changes in MPV may be influenced by disease conditions, current medications, and environments. Although we retrospectively analyzed the Cardiac Arrest Registry in our emergency department, which prospectively collects critical data of patients with out-of-hospital cardiac arrest (OHCA), our registry was simply composed of traditional Utstein style data and frequently used information in the OHCA study because the registry is not intended for providing evidence of the usefulness of MPV as a marker of clinical outcomes after OHCA [1]...
October 25, 2016: Journal of Thrombosis and Haemostasis: JTH
Dong-Hyun Choi, Seong-Ho Kang, Heesang Song
Platelets are essential for progression of atherosclerotic lesions, plaque destabilization, and thrombosis. They secrete and express many substances that are crucial mediators of coagulation, inflammation, and atherosclerosis. Mean platelet volume (MPV) is a precise measure of platelet size, and is routinely reported during complete blood count analysis. Emerging evidence supports the use of MPV as a biomarker predicting the risk of ischemic stroke in patients with atrial fibrillation, and as a guide for prescription of anticoagulation and rhythm-control therapy...
October 24, 2016: Korean Journal of Internal Medicine
A L Litvinenko, A E Moskalensky, N A Karmadonova, V M Nekrasov, D I Strokotov, A I Konokhova, M A Yurkin, E A Pokushalov, A V Chernyshev, V P Maltsev
Whereas commercially available hematological analyzers measure volume of individual platelets, angle-resolved light-scattering provides unique ability to additionally measure their shape index. We utilized the scanning flow cytometer to measure light-scattering profiles (LSPs) of individual platelets taken from 16 healthy donors and the solution of the inverse light-scattering problem to retrieve the volume and shape index of each platelet. In normal conditions, the platelet shape index distribution (PSID) demonstrates three peaks, which relate to resting, partially activated, and fully activated platelets...
October 21, 2016: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
Ayse Carlioglu, Ozge Timur, Senay Durmaz, Mehmet E Ayhan
No abstract text is available yet for this article.
October 13, 2016: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
Li-Li Wang, Ting-Ting Wei, Jian-Rong Yin, Bao-Dong Qin, Ning Ma, Qing-Qin Tang, Lin Zhou, Ren-Qian Zhong
No abstract text is available yet for this article.
October 18, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
Xiaojun Ren, Zhaowei Meng, Ming Liu, Mei Zhu, Qing He, Qing Zhang, Li Liu, Kun Song, Qiyu Jia, Qiang Jia, Xue Li, Jian Tan, Wei Zheng, Renfei Wang, Na Liu, Tianpeng Hu
Mean platelet volume (MPV) and platelet distribution width (PDW) are morphometric indices of size distribution and variability of platelet. We aimed to explore the associations between MPV or PDW and thyroid function in a large Chinese cohort.This was a cross-sectional study with a recruitment of 13,622 self-reported healthy Chinese (8424 males, 5198 females). Clinical data of the participants comprised of anthropometric measurements, hepatic function, renal function, serum levels of lipid, glucose, C-reactive protein, erythrocyte sedimentation rate, platelet, MPV, PDW, and thyroid hormones...
October 2016: Medicine (Baltimore)
Hamoud Al-Mousa, Abbas Hawwari, Abdulaziz Al-Ghonaium, Bandar Al-Saud, Hasan Al-Dhekri, Saleh Al-Muhsen, Sahar Elshorbagi, Majed Dasouki, Lina El-Baik, Amal Alseraihy, Mouhab Ayas, Rand Arnaout
WIP deficiency causes autosomal recessive Wiskott - Aldrich syndromewith normal platelet mean volume and can be cured with hematopoietic stem cell transplantation from genoidentical related or unrelated umbilical cord.
October 11, 2016: Journal of Allergy and Clinical Immunology
Seher Erdoğan, Arzu Oto, Mehmet Boşnak
Mean platelet volume (MPV) is a simple and economical test that is easy to interpret and is routinely measured with automatic cell counters. It indicates platelet volume and platelet function and activation. Variations in platelet volume may occur more as a result of varying differentiation of megakaryocytes in association with production agents in bone marrow rather than of ageing of platelets in circulation. The purpose of this study was to evaluate the relation between mortality and changes in MPV values in patients hospitalized in the pediatric intensive care unit...
November 2015: Turkish Journal of Pediatrics
Cigdem Abide Yayla, Enis Ozkaya, Ahter Tayyar, Taylan Senol, M Baki Senturk, Ates Karateke
BACKGROUND: The aim of this study was to assess the relationship between some complete blood count parameters and placental invasion anomalies. METHODS: Totally 146 pregnants who were suspected for placental invasion anomalies underwent complete blood count screening before cesarean section. In all subjects white blood cell, lymphocyte, neutrophil and platelet counts with red cell distribution width, mean platelet volume, hemoglobin and hematocrit levels were analysed...
October 13, 2016: Journal of Maternal-fetal & Neonatal Medicine
Bartosz Hudzik, Janusz Szkodziński, Jarosław Wasilewski, Marek Gierlotka, Andrzej Lekston, Lech Poloński, Mariusz Gąsior
AIM: We investigated prognostic value of novel simplified thrombo-inflammatory score (sTIPS) in patients with ST-elevation myocardial infarction (STEMI) and diabetes mellitus. METHODS: A total of 465 patients with diabetes mellitus and STEMI were included in the study. Based on admission cut-off values for predicting in-hospital mortality of white blood cell count (>13.4 × 10(3)/mm(3)) and mean platelet volume-to-platelet count ratio (>0.06), the patients were assigned 0 point for having the lower value of each variable and 1 point for having the upper value of each variable...
October 13, 2016: Biomarkers in Medicine
Abhishek Mittal, Bimal K Agrawal, Bharatveer Manchanda
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
R N Sarkar, K Bhattacharya, M Banerjee
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Da-Xiong Zeng
We read the article by Chung and colleagues with great interest [1]. The authors showed that elevated mean platelets volume (MPV) at admission was associated with poor neurological outcomes and mortality at 30 days. MPV levels might be a critical prognostic marker among resuscitated patients. It is an attractive result, but we have some minor criticisms about the study. This article is protected by copyright. All rights reserved.
October 11, 2016: Journal of Thrombosis and Haemostasis: JTH
Gary W Moore, James C Maloney, Robert A Archer, Kerri L Brown, Katarzyna Mayger, Elaine S Bromidge, Mitra F Najafi
BACKGROUND: Autologous platelet-rich plasma (PRP) is gaining increasing use as a wound healing promoter in a variety of clinical settings, including dentistry. Fresh PRP is often used, necessitating daily draws. The present study investigates the possibility of using stored PRP without having to freeze it by storing PRP under variable conditions and assessing growth factor release as a surrogate marker of continued viability. METHODS: Freshly drawn PRP was stored in oxygen permeable and non-oxygen permeable containers under conditions of constant agitation with or without added prostaglandin, intermittent agitation and no agitation, over an 8-day period...
October 8, 2016: British Journal of Biomedical Science
Fatih Akın, Ahmet Sert, Şükrü Arslan
BACKGROUND: Mean platelet volume (MPV), which is commonly used as a measure of platelet size, indicates the rate of platelet production and platelet activation. We aimed to evaluate the mean platelet volume in children with hepatitis A. METHODS: In this retrospective case-controlled study, the study population consisted of 62 children with hepatitis A and 62 healthy control subjects. RESULTS: MPV values, aspartate transaminase (AST), and alanine transaminase (ALT) levels on admission were significantly increased in patients with hepatitis A when compared to controls whereas white blood cell (WBC) counts were significantly lower...
October 6, 2016: Journal of Health, Population, and Nutrition
Peter Rubak, Steen D Kristensen, Anne-Mette Hvas
Immature platelets may contain more platelet enzymes such as cyclooxygenase (COX)-1 and COX-2 than mature platelets. Patients with immune thrombocytopenia (ITP) have a higher fraction of immature platelets and can therefore be utilized as a biological model for investigating COX-1 and COX-2 platelet expression. The aims were to develop flow cytometric assays for platelet COX-1 and COX-2 and to investigate the COX-1 and COX-2 platelet expression, platelet turnover, and platelet glycoproteins in ITP patients (n = 10) compared with healthy individuals (n = 30)...
October 7, 2016: Platelets
Michał Kowara, Kajetan Grodecki, Zenon Huczek, Dominika Puchta, Katarzyna Paczwa, Bartosz Rymuza, Karol Zbroński, Krzysztof J Filipiak, Grzegorz Opolski
BACKGROUND: Platelets' role in pathophysiology of acute coronary syndromes (ACS) is undeniable, but precise relationships between platelet activity and treatment outcomes are matter of continuant investigation. Among platelet indices, mean platelet volume (MPV) has proven to be valuable predicting factor in cardiac patients. However platelet distribution width (PDW) is reported to be more specific marker of platelet reactivity. Thus, application of PDW in risk stratification of ACS treatment is up-to-date subject of research...
October 7, 2016: Kardiologia Polska
Fatih Yılmaz, Erkan Köklü, Filiz Kizilirmak Yilmaz, Elif Sarıönder Gencer, Ahmet Şükrü Alparslan, Özlem Yıldırımtürk
BACKGROUND: Platelets play a significant role in the pathogenesis of atherosclerosis. In atherosclerotic plaques, the risk of plaque rupture is more crucial than the severity of stenosis they cause. Non-calcified carotid artery plaques are more unstable than calcified plaques, and they are associated with a higher risk of rupture, thromboembolism and consequently, stroke. AIM: Purpose of the present study is to compare calcified and non-calcified plaques that cause intermediate carotid artery stenosis with respect to mean platelet volume (MPV) and platelet distribution width (PDW)...
October 7, 2016: Kardiologia Polska
Ali Ugur Uslu, Bahattin Aydin, Sevket Balta, Ozlem Yonem, Tunahan Uncu, Dogan Seven
INTRODUCTION: Chronic hepatitis C (CHC) infection is a systemic disorder that can lead to liver inflammation, fibrosis, cirrhosis, and hepatocellular cancer. The mean platelet volume (MPV) is widely used as an inflammatory marker to evaluate the platelet function and the status of systemic inflammation. AIM: To determine the pre- and post-treatment MPV values in CHC patients who were administered a 48-week antiviral therapy based on systemic inflammation. MATERIAL AND METHODS: We enrolled 28 patients, diagnosed with CHC genotype 1b, who received a 48-week antiviral therapy and attended regular follow-up, and 28 healthy individuals...
2016: Przegla̜d Gastroenterologiczny
Hale Ates, Ihsan Ates, Harun Kundi, Fatma Meric Yilmaz
BACKGROUND: The aim of this study was to determine the hematologic parameter with the highest diagnostic differentiation in the identification of massive acute pulmonary embolism (APE). METHODS: A retrospective study was performed on patients diagnosing with APE between June 2014 and June 2016. All radiological and laboratory parameters of patients were scanned through the electronic information management system of the hospital. PLR was obtained from the ratio of platelet count to lymphocyte count, NLR was obtained from the ratio of neutrophil count to lymphocyte count, WMR was obtained from white blood cell in mean platelet volume ratio, MPR was obtained from the ratio of mean platelet volume to platelet count, and RPR was obtained from the ratio of red distribution width to platelet count...
October 6, 2016: Journal of Clinical Laboratory Analysis
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