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https://www.readbyqxmd.com/read/29791594/low-protein-diet-does-not-alter-reproductive-biochemical-and-hematological-parameters-in-pregnant-wistar-rats
#1
M A V Barros, E B Andrade, R G N Barros, I K M Costa, I C L Costa, G F A Vitorino, J J C Andrade, K M Paulino-Silva, V O Nogueira, J L de Brito Alves, J H Costa-Silva
The aim of this study was to investigate the reproductive, biochemical, and hematological outcomes of pregnant rats exposed to protein restriction. Wistar rat dams were fed a control normal-protein (NP, 17% protein, n=8) or a low-protein (LP, 8% protein, n=14) diet from the 1st to the 20th day of pregnancy. On the 20th day, the clinical signs of toxicity were evaluated. The pregnant rats were then anesthetized and blood samples were collected for biochemical-hematological analyses, and laparotomy was performed to evaluate reproductive parameters...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29790695/elevated-beta-thromboglobulin-and-mean-platelet-volume-levels-may-show-persistent-platelet-activation-in-systemic-lupus-erythematosus-patients
#2
Seyit Uyar, Gul Babacan Abanonu, Seval Masatlioglu Pehlevan, Cumali Karatoprak, Meral Ulukoylu Menguc, Alper Daskin, Suleyman Dolu, Refik Demirtunc
BACKGROUND: Patients with systemic lupus erythematosus (SLE) have an increased risk of thrombotic events. Platelets become more active and they enlarge to release proteins from alpha granules for aggregation during the plaque formation period. Beta-thromboglobulin is one of the proteins released from alpha-granules when platelets are activated and used as a marker of platelet activation in vivo. OBJECTIVES: The aim of this study was to evaluate the plasma levels of beta-thromoglobulin and mean platelet volume as markers of the presence of platelet activation in systemic lupus erythematosus patients compared with healthy controls...
May 17, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29789903/stabilization-of-symptomatic-carotid-atherosclerotic-plaques-by-statins-a-clinico-pathological-analysis
#3
Takao Konishi, Naohiro Funayama, Tadashi Yamamoto, Daisuke Hotta, Ryota Nomura, Yusuke Nakagaki, Takeo Murahashi, Kenji Kamiyama, Tetsuyuki Yoshimoto, Takeshi Aoki, Shinya Tanaka
Human and animal studies have revealed a stabilization of atherosclerotic plaques by statins. However, the stabilization of human carotid plaques has not been thoroughly described pathologically. This analysis explored the relationship between statin therapy and plaque stability in carotid endarterectomy (CEA) specimens. We analyzed specimens harvested between May 2015 and February 2017, from 79 consecutive patients presenting with > 70% carotid artery stenoses, of whom 66 were untreated (group 1) and 13 treated (group 2) with a statin...
May 22, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29786814/predictive-value-of-preoperative-neutrophil-to-lymphocyte-ratio-while-detecting-bowel-resection-in-hernia-with-intestinal-incarceration
#4
Hande Köksal, Derviş Ateş, Emet Ebru Nazik, İlknur Küçükosmanoğlu, Serap Melek Doğan, Osman Doğru
BACKGROUND: The aim of this study was to evaluate the relationship between preoperative hematological inflammatory markers of the patients who underwent a surgery for incarcerated hernia and intestinal resection requirement. METHODS: The data of 102 patients who underwent a surgery for incarcerated hernia were retrospectively evaluated. Whole blood cell counts were preoperatively measured, and operation types and pathology results were recorded. The patients with intestinal resections were compared with those without any resection in terms of leukocyte number, neutrophil rate, red cell distribution width (RDW), platelet distribution width, neutrophil-to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and mean platelet volume (MPV)...
May 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29785471/correction-to-effect-of-sleeve-gastrectomy-on-platelet-counts-and-mean-platelet-volumes
#5
Faruk Kutluturk, Zeki Ozsoy
In the original article, in the Results section of the Abstract the text "…(10.41 ± 1.23 fL, p > 0.001)" should be changed to "…(10.41 ± 1.23 fL, p < 0.001)". The same error occurs on the next page of the article in the second paragraph of the Results section of the main text.
May 21, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29781540/clinical-significance-of-platelet-to-lymphocyte-ratio-in-women-with-preeclampsia
#6
Min-A Kim, Gwan Hee Han, Ja-Young Kwon, Young-Han Kim
PROBLEM: Preeclampsia (PE) is a serious pregnancy complication leading to high maternal, perinatal morbidity, and mortality. We aimed to investigate the clinical effectiveness of the platelet-to-lymphocyte ratio (PLR) in women with PE and compare this measurement to platelet indices as a diagnostic and prognostic marker of PE. METHOD OF STUDY: A total of 471 healthy pregnant women, 126 women diagnosed with mild PE, and 227 with severe PE were included in this retrospective study...
May 21, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29779969/increased-malondialdehyde-vs-reduced-sirtuin-1-in-relation-with-adiposity-atherogenicity-and-hematological-indices-in-metabolic-syndrome-patients-with-and-without-prediabetes
#7
Samar Abu Rkhaya, Nailya Bulatova, Violet Kasabri, Randa Naffa, Reema Alquoqa
BACKGROUND: Sirtuin 1 (SIRT 1) and malondialdehyde (MDA) were implicated in metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM) pathophysiology. AIMS AND METHODS: This cross-sectional study aimed to investigate both SIRT 1 and MDA in 30 lean healthy control, 31 normoglycemic MetS subjects and 30 MetS-Pre/T2DM drug naïve. C orrelation studies were established for both biomarkers with adiposity indices [conicity index (CI), waist circumference (WC), weight-to-height (WHtR) ratio, weight-to-hip (WHR) ratio, hip circumference (HC), and body adiposity index (BAI)], hematological indices [red cell distribution width (RDW), mean platelet volume (MPV), platelet-to-lymphcyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR)] and atherogenicity indices (atherogenicity index of plasma (AIP = log10 TG/HDL-C ratio), TC/HDL-C and LDL-C/HDL-C ratios]...
May 15, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29779399/a-feasibility-study-comparing-platelet-rich-plasma-injection-with-saline-for-the-treatment-of-plantar-fasciitis-using-a-prospective-randomized-trial-design
#8
Sarah Johnson-Lynn, Alan Cooney, Diarmaid Ferguson, Deborah Bunn, William Gray, Jonathan Coorsh, Rajesh Kakwani, David Townshend
Platelet-rich plasma (PRP) has been advocated for treatment of plantar fasciitis but there are few good-quality clinical trials to support its use. We conducted a feasibility study of PRP versus saline for treatment of plantar fasciitis. Patients with 6 months or more of magnetic resonance imaging-proven plantar fasciitis, who had failed conservative treatment were invited to participate in the study. Patients were block randomized to either PRP or an equivalent volume of saline. The techniques used for injection and rehabilitation were standardized for both groups...
May 1, 2018: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29774166/hemostatic-state-augmented-with-platelet-indices-among-sudanese-diabetic-septic-foot
#9
Bashir Abdrhman Bashir, Mohamed Salih Ali
Background: Diabetes mellitus is a very rampant metabolic disorder, particularly type II. It has many complications such as the septic foot. Diabetic septic foot (DSF) patients are at high risk for coagulation abnormalities as well as surgical hazards. Owing to the potential sequelae of coagulation and vascular abnormalities, this work aimed at studying the hemostatic state and platelet indices in diabetes type II patients with septic foot. Methods: A case-control study was conducted during the period from July to September 2017 at Dr...
2018: BMC Hematology
https://www.readbyqxmd.com/read/29765530/mean-platelet-volume-as-a-predictive-marker-for-venous-thromboembolism-in-patients-treated-for-hodgkin-lymphoma
#10
Joanna Rupa-Matysek, Lidia Gil, Marta Barańska, Dominik Dytfeld, Mieczysław Komarnicki
Mean platelet volume (MPV) is reported to be associated with the risk of venous thromboembolism (VTE) and mortality in patients with cancer. We sought to determine the association of MPV with symptomatic VTE occurrence in patients treated for newly diagnosed Hodgkin lymphoma (HL) and their outcomes. We retrospectively studied 167 consecutive adult patients treated with HL. During first-line treatment 12 (7.2%) patients developed VTE and 14 (8%) died within the observation period. The pre-chemotherapy values of MPV were significantly lower in VTE patients than those without (p=0...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29762825/the-prognostic-role-of-platelet-to-lymphocyte-ratio-and-mean-platelet-volume-in-critically-ill-patients
#11
A Yildiz, A Yigit, A R Benli
OBJECTIVE: The aim of this study was to identify the relationship between complete blood count parameters, mean platelet volume (MPV), and platelet to lymphocyte ratio (PLR) with mortality and hospitalization duration in critically ill patients. PATIENTS AND METHODS: A retrospective analysis was made of patients admitted to our tertiary adult i̇ntensive Care Unit (ICU) between January 2015 and January 2016. Hemoglobin (Hb), white blood cell (WBC), lymphocyte and platelet counts were obtained from the complete blood count performed at the time of admission...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29760679/hematocrit-values-predict-carotid-intimal-media-thickness-in-obese-patients-with-non-alcoholic-fatty-liver-disease-a-cross-sectional-study
#12
Giovanni Tarantino, Luigi Barrea, Domenico Capone, Vincenzo Citro, Teresa Mosca, Silvia Savastano
Background: Literature data suggest with some criticism that full-fledged cardiovascular (CV) events (acute or chronic) are likely predicted by blood components, which are reported to be associated with the presence/severity of non-alcoholic fatty liver disease (NAFLD). This study was aimed at determining which marker(s) derived from blood count, such as white blood cells, neutrophils, neutrophil/lymphocyte ratio, platelet count, hemoglobin, mean corpuscular volume, hematocrit values were associated with ear or subclinical atherosclerosis, in obese patients of various classes suffering from NAFLD...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29752673/lead-exposure-is-associated-with-risk-of-impaired-coagulation-in-preschool-children-from-an-e-waste-recycling-area
#13
Zhijun Zeng, Xia Huo, Yu Zhang, Zhehong Xiao, Yuling Zhang, Xijin Xu
Environmental lead exposure leads to various deleterious effects on multiple organs and systems, including the hematopoietic system. To explore the effects of lead exposure on platelet indices in preschool children from an informal, lead-contaminated electronic waste (e-waste) recycling area, we collected venous blood samples from 466 preschool children (331 from an e-waste area (Guiyu) and 135 from a non-e-waste area (Haojiang)). Child blood lead levels (BLLs) were determined by graphite furnace atomic absorption spectrophotometry, while platelet indices were quantified using a Sysmex XT-1800i hematology analyzer...
May 12, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29735870/an-investigation-of-the-effects-of-the-mean-platelet-volume-platelet-distribution-width-platelet-lymphocyte-ratio-and-platelet-counts-on-mortality-in-patents-with-sepsis-who-applied-to-the-emergency-department
#14
M Orak, Y Karakoç, M Ustundag, Y Yildirim, M K Celen, C Güloglu
Aim: The aim of this study is to examine the role of the mean platelet volume (MPV), platelet distribution width (PDW), platelet/lymphocyte ratio (PLR), and platelet values for predicting mortality in patients with sepsis. Materials and Methods: This is a retrospective study, involving patients 18 years and above who were diagnosed with sepsis. Blood samples were analyzed for platelets characteristics (counts, MPV, PDW, and PLR). The patients were separated into two groups namely the survivors and deceased...
May 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29731423/evaluation-of-a-new-continuous-mononuclear-cell-collection-procedure-in-a-single-transplant-center-cohort-enriched-for-al-amyloidosis-patients
#15
Anita Pudusseri, India Smith, Diane Sarnacki, Dina Brauneis, Anthony Shelton, Vaishali Sanchorawala, J Mark Sloan, Shayna Sarosiek, Karen Quillen
BACKGROUND: The Spectra Optia continuous mononuclear cell (CMNC) program is newly available, and herein validated in a single-center cohort enriched with AL amyloidosis patients to collect a target CD34+ yield of 2.5 × 106 cells/kg within 2 days. METHODS: Consecutive autologous transplant patients in 2016 are included. Patients undergo leukapheresis with Optia CMNC and Spectra v4.7 over a 2-day cycle. Data collection includes collection efficiency, adverse events and engraftment kinetics...
April 26, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29725754/mean-platelet-volume-is-associated-with-serum-25-hydroxyvitamin-d-concentrations-in-patients-with-stable-coronary-artery-disease
#16
Ilona Korzonek-Szlacheta, Bartosz Hudzik, Justyna Nowak, Janusz Szkodzinski, Jolanta Nowak, Mariusz Gąsior, Barbara Zubelewicz-Szkodzinska
There is little published data on the association of platelet function and 25(OH)D concentration. We investigated the associations between mean platelet volume (MPV) and 25(OH)D concentration in patients with stable coronary artery disease. Study population was divided into three groups: group 1-25(OH)D < 10 ng/mL (N = 22), group 2-25(OH)D 10-20 ng/mL (N = 42), and group 3-25(OH)D > 20 ng/mL (N = 14). Study groups shared similar demographics. MPV values were the highest in group 1, moderate in group 2, and the lowest in group 3 (11...
May 3, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29720052/high-density-lipoprotein-mean-platelet-volume-and-uric-acid-as-biomarkers-for-outcomes-in-patients-with-sepsis-an-observational-study
#17
Luis Bolívar Montero-Chacón, Juan Ignacio Padilla-Cuadra, Sy Han Chiou, Gabriel Torrealba-Acosta
BACKGROUND: We conducted an observational study evaluating the association between uric acid, mean platelet volume (MPV), and high-density lipoprotein (HDL) with complications and outcomes of patients with sepsis in a critical care setting. METHODS: We followed patients with a diagnosis of severe sepsis and septic shock for a maximum of 28 days. Main outcomes assessed included length of stay (LOS), the need for renal replacement therapy (RRT), assisted mechanical ventilation (AMV), and vasopressor support as well as in-unit mortality...
January 1, 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29717406/effect-of-sleeve-gastrectomy-on-platelet-counts-and-mean-platelet-volumes
#18
Faruk Kutluturk, Zeki Ozsoy
BACKGROUND: Obesity is a chronic metabolic disorder associated with cardiovascular disease, characterized by a chronic proinflammatory and prothrombotic state. The size and hemostatic potential of circulating platelets (PLTs) differ, with larger PLTs containing more granules and producing greater amounts of vasoactive and prothrombotic factors. This study aimed to investigate the effect of laparoscopic sleeve gastrectomy (LSG) on PLT count and mean platelet volume (MPV) in morbidly obese patients...
May 1, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29716700/prognostic-value-of-blood-count-parameters-in-patients-with-acute-coronary-syndrome
#19
Arsalan Majeed Adam, Ather Hasan Rizvi, Amna Haq, Rabia Naseem, Aiman Rehan, Ali Tariq Shaikh, Abdul Haseeb Abbas, Ansab Godil, Arif Ali, Muhammad Saad Ali Mallick, Muhammad Shahzeb Khan, Muhammad Nawaz Lashari
BACKGROUND: Recent studies have shown that complete blood count (CBC) parameters can effectively predict long-term mortality and re-infarction rates in acute coronary syndrome (ACS). However, the role of these parameters in predicting short term mortality has not been studied extensively. The main objective of this study was to determine whether CBC parameters can predict 30-days mortality and the incidence of major adverse cardiac event (MACE) in ACS patients. METHODOLOGY: A total of 297 patients with ACS were recruited in this prospective study...
March 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29716485/the-effects-of-haemodilution-with-succinylated-gelatin-solution-on-coagulation-in-vitro-as-assessed-by-thromboelastometry-and-impedance-multiple-electrode-aggregometry
#20
Pca Kam, S Varanasi, K X Yang
We investigated the in vitro viscoelastic changes of progressive haemodilution with succinylated gelatin (SG) solution compared with normal saline (NS) using rotational thromboelastometry (ROTEM®). Whole blood (WB) samples obtained from 20 healthy volunteers were diluted in vitro with SG solution or NS by 10%, 20% and 40%. Fibrinogen concentration and ROTEM (EXTEM, FIBTEM) variables including coagulation time (CT), clot formation time (CFT), α-angle, and maximum clot firmness (MCF) were measured in the undiluted sample and at each degree of haemodilution...
May 2018: Anaesthesia and Intensive Care
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