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Cardiovascular comorbidity

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https://www.readbyqxmd.com/read/29905897/patterns-of-injury-and-outcomes-in-the-elderly-patient-with-rib-fractures-a-multicenter-observational-study
#1
Mark G Van Vledder, Vicky Kwakernaak, Tjebbe Hagenaars, Esther M M Van Lieshout, Michiel H J Verhofstad
BACKGROUND: High rates of pneumonia and death have been reported among elderly patients with rib fractures. This study aims to identify patterns of injury and risk factors for pneumonia and death in elderly patients with rib fractures. METHODS: A retrospective multicenter observational study was performed using data registered in the national trauma registry between 2008 and 2015 in the South West Netherlands Trauma region. Data regarding demographics, mechanism of injury, pulmonary and cardiovascular history, pattern of extra-thoracic and intrathoracic injuries, ICU admission, length of stay, and morbidity and mortality following admission were collected...
June 15, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29905848/uraemic-symptom-burden-and-clinical-condition-in-women-and-men-of-%C3%A2-65-years-of-age-with-advanced-chronic-kidney-disease-results-from-the-equal-study
#2
Moniek W M van de Luijtgaarden, Fergus J Caskey, Christoph Wanner, Nicholas C Chesnaye, Maurizio Postorino, Cynthia J Janmaat, Anirudh Rao, Claudia Torino, Marian Klinger, Christiane Drechsler, Olof Heimburger, Maciej Szymczak, Marie Evans, Friedo W Dekker, Kitty J Jager
Background: The epidemiology and prognosis of chronic kidney disease (CKD) differ by sex. We aimed to compare symptom prevalence and the clinical state in women and men of ≥65 years of age with advanced CKD receiving routine nephrology care. Methods: The European QUALity study on treatment in advanced chronic kidney disease (EQUAL) study follows patients from six European countries of ≥65 years of age  years whose estimated glomerular filtration rate (eGFR) dropped to ≤20 mL/min/1...
June 13, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29905489/assisted-reproductive-technology-comorbidities-and-cardiovascular-risk-the-experience-of-an-italian-center
#3
Cinzia Fatini, Michela Cirillo, Maria Elisabetta Coccia
BACKGROUND: A growing number of infertile women undergo assisted reproductive technology (ART). Older maternal age and the presence of comorbidities may affect cardiovascular (CV) women health. Safety aspects are central in risk assessment; we report the experience of internal medicine clinical setting at the ART center. MATERIALS AND METHODS: we investigated 243 infertile women (110 autologous and 133 oocyte donation [OD]); cardiometabolic parameters and CV risk factors were investigated during the clinical evaluation...
June 15, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29904903/nurse-s-contribution-to-alleviate-non-adherence-to-hypertension-treatment
#4
REVIEW
G Georgiopoulos, Z Kollia, V Katsi, D Oikonomou, C Tsioufis, D Tousoulis
PURPOSE OF REVIEW: Hypertension consists a major risk factor for cardiovascular events. Despite the proven effectiveness of antihypertensive treatment, approximately half of hypertensive patients have inadequate blood pressure control. Non-adherence to medication has been shown to be an important barrier to achieving adequate blood pressure control and nurse interventions can substantially improve therapeutic compliance. We sought to evaluate the role of nurse interventions in alleviating non-adherence to medication in patients with hypertension by performing a systematic review of the literature for all relevant articles...
June 15, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29904633/physiology-of-hyperuricemia-and-urate-lowering-treatments
#5
REVIEW
Caroline L Benn, Pinky Dua, Rachel Gurrell, Peter Loudon, Andrew Pike, R Ian Storer, Ciara Vangjeli
Gout is the most common form of inflammatory arthritis and is a multifactorial disease typically characterized by hyperuricemia and monosodium urate crystal deposition predominantly in, but not limited to, the joints and the urinary tract. The prevalence of gout and hyperuricemia has increased in developed countries over the past two decades and research into the area has become progressively more active. We review the current field of knowledge with emphasis on active areas of hyperuricemia research including the underlying physiology, genetics and epidemiology, with a focus on studies which suggest association of hyperuricemia with common comorbidities including cardiovascular disease, renal insufficiency, metabolic syndrome and diabetes...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29903898/dialysis-provider-and-outcomes-among-united-states-veterans-who-transition-to-dialysis
#6
Elani Streja, Csaba Pal Kovesdy, Melissa Soohoo, Yoshitsugu Obi, Connie M Rhee, Christina Park, Joline L T Chen, Tracy Nakata, Danh V Nguyen, Alpesh N Amin, Steven J Jacobsen, John J Sim, Kamyar Kalantar-Zadeh
BACKGROUND AND OBJECTIVES: Veterans with ESKD initiate dialysis under the Veterans Health Administration (VHA), an integrated health system, or are outsourced to non-VHA providers. It is unknown whether outcomes differ according to their dialysis provider at initiation. We sought to evaluate the association between dialysis provider and mortality and hospitalization among United States veterans initiating dialysis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Among 68,727 United States veterans who initiated dialysis in 2007-2014, we examined the association of dialysis provider (VHA versus non-VHA) at initiation with mortality and hospitalization rates in the first 12 months post-initiation...
June 14, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29902554/resource-use-during-the-last-6-months-of-life-among-copd-patients-a-population-level-study
#7
Kristof Faes, Joachim Cohen, Lieven Annemans
CONTEXT: Chronic obstructive pulmonary disease (COPD) patients often have several comorbidities, such as cardiovascular diseases (CVD) or lung cancer (LC), which might influence resource use in the final months of life. However, no previous studies documented resource use in end-of-life COPD patients at a population level, thereby differentiating whether COPD patients die of their COPD, CVD or LC. AIM: To describe end-of-life resource use in people diagnosed with COPD and compare this resource use between those dying of COPD, CVD and LC...
June 11, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29902313/association-of-cardiovascular-comorbidities-with-hearing-loss-in-the-older-old
#8
Kapil Wattamwar, Z Jason Qian, Jenna Otter, Matthew J Leskowitz, Francesco F Caruana, Barbara Siedlecki, Jaclyn B Spitzer, Anil K Lalwani
Importance: In the United States, the population of individuals older than 80 years is expected to double in the next 40 years. Cardiovascular comorbidities are prevalent in this older old population, and their relationship with hearing loss has not been well characterized. Objective: To investigate the association of cardiovascular disease (CVD)-related risk factors with auditory function among the older old (>80 years). Design, Setting, and Participants: Audiological data and medical records from 2001 through 2014 of 433 patients aged 80 to 106 years at an academic medical center were analyzed in 2017...
June 14, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29899174/excessive-daytime-sleepiness-is-associated-with-depression-scores-but-not-with-sleep-disordered-breathing-in-patients-with-cardiovascular-diseases
#9
Mikiko Ohashi, Takashi Kohno, Shun Kohsaka, Ryoma Fukuoka, Kentaro Hayashida, Shinsuke Yuasa, Motoaki Sano, Seiji Takatsuki, Keiichi Fukuda
BACKGROUND: Excessive daytime sleepiness (EDS) is a significant public health concern, with sleep-disordered breathing (SDB) being a common cause. However, their precise relationship in patients with cardiovascular disease (CVD) is unclear. Furthermore, whether comorbid psychological disorders could contribute to EDS remains unknown. We aimed to assess the prevalence of EDS and its related factors, including SDB and depression, in patients with CVD.Methods and Results:We analyzed data from 1,571 patients admitted for various CVDs in a single university hospital (median age, 67 [56-76] years; 29...
June 13, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29898625/branched-chain-amino-acids-are-associated-with-metabolic-parameters-in-bipolar-disorder
#10
F T Fellendorf, M Platzer, R Pilz, A Rieger, H P Kapfhammer, H Mangge, N Dalkner, S Zelzer, A Meinitzer, A Birner, S A Bengesser, R Queissner, C Hamm, R Hartleb, E Z Reininghaus
OBJECTIVES: An important aspect of bipolar disorder (BD) research is the identification of biomarkers pertaining to the somatic health state. The branched-chain essential amino acids (BCAAs), viz valine, leucine and isoleucine, have been proposed as biomarkers of an individual's health state, given their influence on protein synthesis and gluconeogenesis inhibition. METHODS: BCAA levels of 141 euthymic/subsyndromal individuals with BD and 141 matched healthy controls (HC) were analyzed by high-pressure lipid chromatography and correlated with clinical psychiatric, anthropometric and metabolic parameters...
June 14, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29898045/prevalence-and-factors-associated-with-metabolic-syndrome-among-brazilian-adult-population-national-health-survey-2013
#11
Elyssia Karine Nunes Mendonça Ramires, Risia Cristina Egito de Menezes, Giovana Longo-Silva, Taíse Gama Dos Santos, Patrícia de Menezes Marinho, Jonas Augusto Cardoso da Silveira
BACKGROUND: In Brazil, population-based researches analyzing prevalence and factors associated with metabolic syndrome (MS), a recognized predictor of cardiovascular diseases (CVD), and an important cause of disability and death in the country are scarce. OBJECTIVE: To evaluate prevalence of MS and its associated factors in Brazilian population. METHODS: Secondary analysis of the 2013 National Health Survey, a cross-sectional survey with national representativeness of Brazilian adult population (n = 59,402)...
May 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29896566/intermittent-hypoxia-and-hypercapnia-a-hallmark-of-obstructive-sleep-apnea-alters-the-gut-microbiome-and-metabolome
#12
Anupriya Tripathi, Alexey V Melnik, Jin Xue, Orit Poulsen, Michael J Meehan, Gregory Humphrey, Lingjing Jiang, Gail Ackermann, Daniel McDonald, Dan Zhou, Rob Knight, Pieter C Dorrestein, Gabriel G Haddad
Obstructive sleep apnea (OSA) is a common disorder characterized by episodic obstruction to breathing due to upper airway collapse during sleep. Because of the episodic airway obstruction, intermittently low O2 (hypoxia) and high CO2 (hypercapnia) ensue. OSA has been associated with adverse cardiovascular and metabolic outcomes, although data regarding potential causal pathways are still evolving. As changes in inspired O2 and CO2 can affect the ecology of the gut microbiota and the microbiota has been shown to contribute to various cardiometabolic disorders, we hypothesized that OSA alters the gut ecosystem, which, in turn, exacerbates the downstream physiological consequences...
May 2018: MSystems
https://www.readbyqxmd.com/read/29896436/frailty-in-older-adults-with-cardiovascular-disease-cause-effect-or-both
#13
Emma Ef Kleipool, Emiel O Hoogendijk, Marijke C Trappenburg, M Louis Handoko, Martijn Huisman, Mike Jl Peters, Majon Muller
Cardiovascular disease (CVD) has been associated with an increased risk of frailty, but the direction of the association remains unclear. This study set out to examine the bidirectional longitudinal association between CVD and frailty over an extended period of time. Data are from 1432 older adults (aged 65-88yrs) of the Longitudinal Aging Study Amsterdam (LASA), who were followed for 17 years. At baseline and follow-up, CVD was assessed through self-report, medication use and medical records, and classified as angina pectoris, myocardial infarction, heart failure (HF), stroke, and peripheral artery disease...
June 2018: Aging and Disease
https://www.readbyqxmd.com/read/29895596/neuroleptic-prescribing-and-monitoring-practices-in-pediatric-inpatient-medical-and-psychiatric-settings
#14
Lan Le, Jolene R Bostwick, Arnold Andreasen, Nasuh Malas
BACKGROUND: Pediatric use of second-generation antipsychotics, or neuroleptics, has increased over the past decade. Neuroleptic use can have significant and lasting adverse neurologic, metabolic, and cardiovascular effects. In the current literature, neuroleptic prescribing and monitoring is described in outpatient settings, with little description of inpatient pediatric practice. In this study, we are the first to explore prescribing and monitoring in inpatient pediatrics, highlighting similarities and differences in practice between pediatric medicine and psychiatry...
June 12, 2018: Hospital Pediatrics
https://www.readbyqxmd.com/read/29895169/mesenchymal-stromal-cell-characteristics-and-regenerative-potential-in-cardiovascular-disease-implications-for-cellular-therapy
#15
F C C van Rhijn-Brouwer, H Gremmels, J O Fledderus, M C Verhaar
Administration of mesenchymal stromal cells (MSCs) is a promising strategy to treat cardiovascular disease (CVD). As progenitor cells may be negatively affected by both age and comorbidity, characterization of MSC function is important to guide decisions regarding use of allogeneic or autologous cells. Definitive answers on which factors affect MSC function can also aid in selecting which MSC donors would yield the most therapeutically efficacious MSCs. Here we provide a narrative review of MSC function in CVD based on a systematic search...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29895033/metabolic-syndrome-in-hypopituitarism
#16
Dragana Miljić, Vera Popovic
Prevalence of metabolic syndrome (MetS) and mortality rates from cardiovascular causes are increased in patients with hypopituitarism. Features of obesity, visceral adiposity, dyslipidemia, insulin resistance, and hypertension are common in these patients. Unreplaced growth hormone (GH) deficiency and inadequate replacement of other hormone insufficiencies may be responsible for the adverse body composition and metabolic profile associated with hypopituitarism. Recently, fatty liver disease was added to this unfavorable metabolic phenotype...
2018: Frontiers of Hormone Research
https://www.readbyqxmd.com/read/29893297/18f-fluorodeoxyglucose-positron-emission-tomography-based-evaluation-of-systemic-and-vascular-inflammation-and-assessment-of-the-effect-of-systemic-treatment-on-inflammation-in-patients-with-moderate-to-severe-psoriasis-a-randomized-placebo-controlled-pilot
#17
Sharonjeet Kaur, Nusrat Shafiq, Sunil Dogra, B R Mittal, Savita Verma Attri, Ajay Bahl, Tarun Narang, Keshavamurthy Vinay, Sujit Rajagopalan, Samir Malhotra
Background: Psoriasis is a systemic inflammatory disorder associated with an increased risk of cardiovascular disease. Objective: To evaluate the utility of [18 F]-fluorodeoxyglucose positron emission tomography/computed tomography in identifying vascular and systemic inflammation in psoriasis patients with moderate-to-severe disease and to analyze its usefulness in assessing the effect of systemic treatment. Methods: This was a randomized, double-blind pilot study conducted in a tertiary care center...
June 8, 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29892007/familial-hypercholesterolemia-in-very-young-myocardial-infarction
#18
Sha Li, Hui-Wen Zhang, Yuan-Lin Guo, Na-Qiong Wu, Cheng-Gang Zhu, Xi Zhao, Di Sun, Xiong-Yi Gao, Ying Gao, Yan Zhang, Ping Qing, Xiao-Lin Li, Jing Sun, Geng Liu, Qian Dong, Rui-Xia Xu, Chuan-Jue Cui, Jian-Jun Li
Familial hypercholesterolemia (FH) is one of the most common causes of premature myocardial infarction (MI). However, The patterns of FH remained unrecognized in clinical care, especially in very young patients (VYPs, ≤35 years) with MI. The present study enrolled a total of 1,093 VYPs (≤35 years) presenting a first MI. Clinical diagnosis of FH was made using Dutch Lipid Clinic Network criteria. Coronary severity was assessed by Gensini score (GS). Patients were followed for a median of 40-months with cardiac death, stroke, MI, post-discharge revascularization or unstable angina as primary endpoints...
June 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29891748/characteristics-of-patients-initializing-peritoneal-dialysis-treatment-from-2007-to-2014-analysis-from-henan-peritoneal-dialysis-registry-data
#19
Xiaoxue Zhang, Ying Chen, Yamei Cai, Xing Tian, Jing Xiao, Zhanzheng Zhao, Dahai Yu
INTRODUCTION: This study aimed to assess the number and profiles of patients initializing peritoneal dialysis form the Henan Peritoneal Dialysis Registry, a provincial database in central China. MATERIALS AND METHODS: All patients aged 18 years and greater, initializing peritoneal dialysis within the province during 2007 to 2014 were included. Demographic characteristics were collected and clinical parameters included the type of renal diagnosis (primary glomerular, secondary glomerular, and others) and recorded major comorbidities in the neural, cardiovascular, respiratory, gastrointestinal, and endocrine systems...
May 2018: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29891436/role-of-experience-with-preventive-medication-and-personal-risk-attitude-in-non-attendance-at-triple-vascular-screening
#20
Tina B Hansen, Jes S Lindholt, Rikke Søgaard
BACKGROUND: Non-attendance for vascular screening potentially restricts the overall benefit of screening at population level, but may be the result of rational judgment on the part of invitees who might not consider their risk to be relevant. The aim of this study was to investigate the role of current use of preventive medication and personal risk attitude as potential factors explaining non-attendance at triple vascular screening. METHODS: This was a case control study across 25,078 men offered screening and intervention for abdominal aortic aneurysm, peripheral artery disease, and hypertension in the Viborg Vascular (VIVA) screening trial...
June 8, 2018: European Journal of Vascular and Endovascular Surgery
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