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Cardiovascular comorbidity

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https://www.readbyqxmd.com/read/29667144/efficacy-and-safety-of-zofenopril-versus-ramipril-in-the-treatment-of-myocardial-infarction-and-heart-failure-a-review-of-the-published-and-unpublished-data-of-the-randomized-double-blind-smile-4-study
#1
REVIEW
Claudio Borghi, Stefano Omboni, Salvatore Novo, Dragos Vinereanu, Giuseppe Ambrosio, Ettore Ambrosioni
Zofenopril is a lipophilic, sulfhydryl group-containing angiotensin-converting enzyme (ACE)-inhibitor, characterized by wide tissue distribution, long duration of action, and pleiotropic effects on endothelial dysfunction. Its clinical efficacy and safety have been described in the four randomized controlled trials of the SMILE program, which globally enrolled more than 3600 patients in post-acute myocardial infarction (AMI) setting. The SMILE-4 study specifically selected patients with left ventricular dysfunction at admission, and compared the effects of zofenopril or ramipril in combination with acetylsalicylic acid (ASA)...
April 17, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29664343/peripheral-arterial-disease-changes-in-clinical-outcomes-and-therapeutic-strategies-in-two-cohorts-from-2002-to-2008-and-from-2008-to-2014-a-population-based-study
#2
Marta Baviera, Vittorio Bertelè, Fausto Avanzini, Tommaso Vannini, Mauro Tettamanti, Ida Fortino, Angela Bortolotti, Luca Merlino, Maria Carla Roncaglioni
Background The aim of our study was to evaluate whether treatments for peripheral artery disease changed in two different cohorts identified in 2002 and 2008, and whether this had an impact on mortality and major clinical outcomes after six years of follow-up. Methods Using administrative health databases of the largest region in Northern Italy, we identified patients admitted to hospital for peripheral artery disease in 2002 and 2008. Both cohorts were followed for six years. All cause death, acute coronary syndrome, stroke and major amputations, cardiovascular prevention drugs and revascularization procedures were collected...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29663641/congenital-heart-diseases-and-cardiovascular-abnormalities-in-22q11-2-deletion-syndrome-from-well-established-knowledge-to-new-frontiers
#3
REVIEW
Marta Unolt, Paolo Versacci, Silvia Anaclerio, Caterina Lambiase, Giulio Calcagni, Matteo Trezzi, Adriano Carotti, Terrence Blaine Crowley, Elaine H Zackai, Elizabeth Goldmuntz, James William Gaynor, Maria Cristina Digilio, Donna M McDonald-McGinn, Bruno Marino
Congenital heart diseases (CHDs) and cardiovascular abnormalities are one of the pillars of clinical diagnosis of 22q11.2 deletion syndrome (22q11.2DS) and still represent the main cause of mortality in the affected children. In the past 30 years, much progress has been made in describing the anatomical patterns of CHD, in improving their diagnosis, medical treatment, and surgical procedures for these conditions, as well as in understanding the underlying genetic and developmental mechanisms. However, further studies are still needed to better determine the true prevalence of CHDs in 22q11...
April 16, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29663313/microbleeds-in-ischemic-vs-hemorrhagic-strokes-on-novel-oral-anticoagulants
#4
J C Purrucker, M Wolf, K Haas, T Siedler, T Rizos, S Khan, P U Heuschmann, R Veltkamp
OBJECTIVES: To identify differences in clinical characteristics and severity of cerebral small vessel disease (CSVD) including cerebral microbleeds (CMBs), between patients suffering ischemic stroke (IS) or intracerebral hemorrhage (ICH) while taking novel (non-vitamin K antagonists) oral anticoagulants (NOACs). METHODS: Multicenter, prospective, observational cohort study performed at 38 centers between 2012 and 2015. We compared demographics, comorbidity, and functional status (before and after stroke) between NOAC-IS and NOAC-ICH patients...
April 16, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29662724/frequency-and-determinants-of-inappropriate-use-of-treadmill-stress-test-for-coronary-artery-disease
#5
Muhammad Bilal, Abdul Haseeb, Mohammad H Arshad, Altamash A Jaliawala, Iman Farooqui, Amna Minhas, Ahmedullah Hussaini, Arsalan A Khan, Sharjeel Ahmad, Zainab Saleem, Ozair Awan, Noor Us Sabahat, Araib Ayaz, Haania Rizwan
Background In developing countries like Pakistan, treatment is mediated by private and public healthcare setups with a limited budget for health facilities. Moreover, the inappropriate use of treadmill tests imposes a burden on healthcare resources and leads to unwarranted interventions. Our aim is to assess the prevalence and predictors of inappropriate referrals for the exercise tolerance test (ETT) to diagnose coronary artery disease (CAD) while taking public and private healthcare settings into consideration...
January 23, 2018: Curēus
https://www.readbyqxmd.com/read/29662656/stereotactic-body-radiation-therapy-for-palliative-management-of-pancreatic-adenocarcinoma-in-elderly-and-medically-inoperable-patients
#6
John F Ryan, Lauren M Rosati, Vincent P Groot, Dung T Le, Lei Zheng, Daniel A Laheru, Eun J Shin, Juan Jackson, Joseph Moore, Amol K Narang, Joseph M Herman
Stereotactic body radiation therapy (SBRT) represents a promising treatment option for patients with localized pancreatic ductal adenocarcinoma (PDAC) who cannot tolerate surgical therapy. We retrospectively reviewed the records of patients with localized PDAC treated with SBRT at our institution between 2010 and 2016 to identify patients deemed medically inoperable due to poor performance status, advanced age, and/or comorbid conditions. Overall survival (OS), progression-free survival (PFS), and local progression-free survival (LPFS) were estimated using Kaplan-Meier curves...
March 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29661646/physical-activity-to-improve-erectile-function-a-systematic-review-of-intervention-studies
#7
REVIEW
Helle Gerbild, Camilla Marie Larsen, Christian Graugaard, Kristina Areskoug Josefsson
INTRODUCTION: The leading cause of erectile dysfunction (ED) is arterial dysfunction, with cardiovascular disease as the most common comorbidity. Therefore, ED is typically linked to a web of closely interrelated cardiovascular risk factors such as physical inactivity, obesity, hypertension, and metabolic syndrome. Physical activity (PA) has proved to be a protective factor against erectile problems, and it has been shown to improve erectile function for men affected by vascular ED. This systematic review estimated the levels of PA needed to decrease ED for men with physical inactivity, obesity, hypertension, metabolic syndrome, and/or manifest cardiovascular diseases...
April 13, 2018: Sexual Medicine
https://www.readbyqxmd.com/read/29661541/ckd-and-esrd-in-us-hispanics
#8
REVIEW
Nisa Desai, Claudia M Lora, James P Lash, Ana C Ricardo
Hispanics are the largest racial/ethnic minority group in the United States, and they experience a substantial burden of kidney disease. Although the prevalence of chronic kidney disease (CKD) is similar or slightly lower in Hispanics than non-Hispanic whites, the age- and sex-adjusted prevalence rate of end-stage renal disease is almost 50% higher in Hispanics compared with non-Hispanic whites. This has been attributed in part to faster CKD progression among Hispanics. Furthermore, Hispanic ethnicity has been associated with a greater prevalence of cardiovascular disease risk factors, including obesity and diabetes, as well as CKD-related complications...
April 13, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29660181/descriptive-versus-mechanistic-scientific-approach-to-study-wound-healing-and-its-inhibition-is-there-a-value-of-translational-research-involving-human-subjects
#9
REVIEW
Irena Pastar, Lulu Lu Wong, Andjela N Egger, Marjana Tomic-Canic
The clinical field of wound healing is challenged by numerous hurdles. Not only are wound healing disorders complex and multifactorial, but the corresponding patient population is diverse, often elderly and burdened by multiple comorbidities such as diabetes, cardiovascular disease, etc. The care of such patients requires a dedicated, multi-disciplinary team of physicians, surgeons, nurses, and scientists. In spite of the critical clinical need, it has been over 15 years since a treatment received approval for efficacy by the FDA in the United States...
April 16, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29658833/gonadopenia-and-aging-in-men
#10
Sandeep Singh Dhindsa, Michael S Irwig, Kathleen Wyne
OBJECTIVE: The decrease in testosterone levels that occurs with aging has become an important clinical issue both due to the growth of the geriatric population and patient interest in testosterone therapy. The decision to assess for testosterone deficiency and the ability to determine whether the benefits exceed the risks require a comprehensive evaluation of the aging patient. This article is part of a series of papers focused on the endocrinology of aging. This review addresses common issues needed for clinical decision making, including how to interpret test results, differential diagnosis, potential impact of testosterone treatment on insulin resistance and cardiovascular disease, and options for therapy...
April 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29658678/emergency-surgery-for-bowel-obstruction-in-extremely-aged-patients
#11
Alberto Oldani, Valentina Gentile, Chiara Magaton, Marcello Calabrò, Fabio Maroso, Lidia Ravizzini, Giacomo Deiro, Maurizio Amato, Sergio Gentilli
BACKGROUND: As a result of the increasing of life expectancy, the incidence of pathologies that can lead to operation for bowel obstruction is also increasing. Comorbidities and reduced physiological reserve can decrease elderly patients' ability to tolerate operations especially in an emergency context. We retrospectively evaluated the treatment and outcomes of a cohort of patients aged more than 85 years who underwent emergency surgery for intestinal occlusion. METHODS: 278 patients who were admitted to our Institution and operated for acute bowel obstruction have been included in our study...
April 13, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29657148/the-prevalence-of-renal-impairment-in-patients-with-spondyloarthritis-results-from-the-international-asas-comospa-study
#12
Marion Couderc, Bruno Pereira, Anna Molto, Aurélien Tiple, Martin Soubrier, Maxime Dougados
OBJECTIVE: To assess the prevalence and association of renal dysfunction in patients with spondyloarthritis (SpA). METHODS: The ASAS-COMOSPA (Assessment of Spondyloarthritis international Society-COMOrbidities in SPondyloArthritis) was an international study (22 participating countries from 4 continents) investigating comorbidities in SpA. Renal function was assessed based on estimated glomerular filtration rate (eGFR) calculated using the Modification of Diet in Renal Disease equation...
April 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29657040/left-ventricular-volume-and-wall-stress-are-linked-to-lung-function-impairment-in-copd
#13
Peter Alter, Rudolf A Jörres, Henrik Watz, Tobias Welte, Sven Gläser, Holger Schulz, Robert Bals, Annika Karch, Emiel F M Wouters, Jørgen Vestbo, David Young, Claus F Vogelmeier
BACKGROUND: Cardiovascular comorbidities are common in chronic obstructive pulmonary disease (COPD). We examined the association between airflow limitation, hyperinflation and the left ventricle (LV). METHODS: Patients from the COPD cohort COSYCONET underwent evaluations including forced expiratory volume in 1 s (FEV1 ), forced vital capacity (FVC), effective airway resistance (Reff ), intrathoracic gas volume (ITGV), and echocardiographic LV end-diastolic volume (LVEDV), stroke volume (LVSV), end-systolic volume (LVESV), and end-diastolic and end-systolic LV wall stress...
June 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29652956/-tools-for-physical-activity-assessment-in-chronic-obstructive-pulmonary-disease
#14
Rodrigo Torres-Castro, Cristian Céspedes, Jordi Vilaró, Roberto Vera-Uribe, Marcelo Cano-Cappellacci, Diego Vargas
The prevalence and mortality of chronic obstructive pulmonary disease (COPD) is increasing in Chile, constituting a public health problem. Pulmonary and systemic consequences of COPD affect physical activity, as the disease progresses. There are multiple means for physical activity assessment, from low cost and easily applicable questionnaires to sophisticated laboratory tests. Physical inactivity is a modifiable risk factor for morbidity and mortality in patients with COPD. Physical activity interventions not only contribute to decrease the likelihood of mortality, but also protect from comorbidities, especially cardiovascular ones...
December 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29652166/ambulance-use-distance-and-outcomes-in-patients-with-suspected-cardiovascular-disease-a-registry-based-geographic-information-system-study
#15
Nariman Sepehrvand, Wendimagegn Alemayehu, Padma Kaul, Rick Pelletier, Aminu K Bello, Robert C Welsh, Paul W Armstrong, Justin A Ezekowitz
BACKGROUND: Despite guideline recommendations, the majority of patients with symptoms suggestive of acute coronary syndrome do not use emergency medical services to reach the emergency department (ED). The aim of this study was to investigate the factors associated with EMS utilisation and subsequent patient outcomes. METHODS: Using administrative data, all patients who presented to an ED in the metropolitan areas of Edmonton and Calgary in the years of 2007-2013 with main ED diagnosis of acute coronary syndrome, stable angina or chest pain were included...
April 1, 2018: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/29651743/polypharmacy-in-palliative-care-copd-and-multimorbidity-a-case-report
#16
Marcel Rowhani, Bernhard Iglseder
This is the case report of an 80-year-old woman with advanced chronic obstructive pulmonary disease (COPD), multimorbidity and frailty. Despite regular critical re-evaluation of on-going medication, a significant reduction of prescribed medication was not achieved up until the patient's terminal phase, and this may have contributed to several episodes of delirium. It was particularly difficult to reduce the number of prescribed drugs due to cardiovascular, endocrinologic, orthopaedic, neurologic, psychiatric and pulmonary comorbidities...
April 12, 2018: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29651409/incidence-of-comorbidities-in-women-with-breast-cancer-treated-with-tamoxifen-or-an-aromatase-inhibitor-an-australian-population-based-cohort-study
#17
Huah Shin Ng, Bogda Koczwara, David Roder, Theo Niyonsenga, Agnes Vitry
Background: The development of comorbidities has become increasingly relevant with longer-term cancer survival. Objective: To assess the pattern of comorbidities among Australian women with breast cancer treated with tamoxifen or an aromatase inhibitor. Design: Retrospective cohort study using Pharmaceutical Benefits Scheme (PBS) data (10% sample) from January 2003 to December 2014. Dispensing claims data were used to identify comorbidities and classified with the Rx-Risk-V model...
2018: Journal of Comorbidity
https://www.readbyqxmd.com/read/29649579/prognostic-value-of-nutrition-status-in-the-response-of-cardiac-resynchronization-therapy
#18
Belén Alvarez-Alvarez, Javier García-Seara, Moisés Rodríguez-Mañero, Diego Iglesias-Alvarez, Jose L Martínez-Sande, Rosa M Agra-Bermejo, Xesús A Fernández López, Laila González-Melchor, Francisco Gude Sampedro, Carla Díaz-Louzao, José R González-Juanatey
BACKGROUND: Cardiac resynchronization therapy (CRT) is indicated in symptomatic heart failure (HF) patients after achieving optimal medical therapy. However, there are still a large percentage of patients who do not respond to CRT. Malnutrition is a frequent comorbidity in patients with HF, and it is associated with a poorer prognosis. Here, we evaluate the nutritional status of patients assessed by Controlling Nutritional Status (CONUT) score and its association with structural remodeling and cardiovascular events...
April 9, 2018: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/29649323/prognosis-of-cardiovascular-and-non-cardiovascular-multimorbidity-after-acute-coronary-syndrome
#19
Silvia Canivell, Olivier Muller, Baris Gencer, Dik Heg, Roland Klingenberg, Lorenz Räber, David Carballo, Christian Matter, Thomas Lüscher, Stephan Windecker, François Mach, Nicolas Rodondi, David Nanchen
OBJECTIVE: To examine the prognosis of patients with cardiovascular and non-cardiovascular multimorbidity after acute coronary syndrome compared to patients without prior multimorbidity. METHODS: This multicenter prospective cohort study in Switzerland included 5,635 patients hospitalized with acute coronary syndrome between 2009 and 2014, with a one-year follow-up period. We defined cardiovascular and non-cardiovascular multimorbidity as having at least two prior comorbidities before the index hospitalization...
2018: PloS One
https://www.readbyqxmd.com/read/29649034/obstructive-sleep-apnea-in-pregnant-women-a-review-of-pregnancy-outcomes-and-an-approach-to-management
#20
Jennifer E Dominguez, Andrew D Krystal, Ashraf S Habib
Among obese pregnant women, 15%-20% have obstructive sleep apnea (OSA) and this prevalence increases along with body mass index and in the presence of other comorbidities. Prepregnancy obesity and pregnancy-related weight gain are certainly risk factors for sleep-disordered breathing in pregnancy, but certain physiologic changes of pregnancy may also increase a woman's risk of developing or worsening OSA. While it has been shown that untreated OSA in postmenopausal women is associated with a range of cardiovascular, pulmonary, and metabolic comorbidities, a body of literature is emerging that suggests OSA may also have serious implications for the health of mothers and fetuses during and after pregnancy...
April 11, 2018: Anesthesia and Analgesia
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