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Alessandro Coppe, Leonardo Nogara, Matteo Samuele Pizzuto, Alice Cani, Simone Cesaro, Riccardo Masetti, Franco Locatelli, Geertruy Te Kronnie, Giuseppe Basso, Stefania Bortoluzzi, Silvia Bresolin
The WAS gene product is expressed exclusively in the cytoplasm of hematopoietic cells and constitutional genetic abrogation of WASP leads to Wiskott-Aldrich syndrome (WAS). Moreover, mutational activation of WASP has been associated with X-linked neutropenia. Although studies reported that patients with constitutional WAS mutations affecting functional WASP expression may present juvenile myelomonocytic leukemia (JMML)-like features, confounding differential diagnosis above all in the copresence of mutated RAS, an activating somatic mutation of WASP has not been previously described in JMML patients...
April 2018: Human Mutation
Noriko Usui
In the original publication of this article, the "Acknowledgements" was not included and it is given below for your reading.
October 12, 2017: International Journal of Hematology
Noriko Usui
No abstract text is available yet for this article.
November 2017: International Journal of Hematology
Balasubramanian Suriyanarayanan, Praveena Pothuraju Lakshmi, Ramachandran Sarojini Santhosh, Kandasamy Dhevendaran, Balakrishnan Priya, Shivaani Krishna
Streptomycin, an antibiotic used against microbial infections, inhibits the protein synthesis by binding to ribosomal protein S12, encoded by rpsL12 gene, and associated mutations cause streptomycin resistance. A streptomycin resistant, Lysinibacillus sphaericus DSLS5 (MIC >300 µg/mL for streptomycin), was isolated from a marine sponge (Tedania anhelans). The characterisation of rpsL12 gene showed a region having similarity to long terminal repeat sequences of murine lukemia virus which added 13 amino acids for loop formation in RpsL12; in addition, a K56R mutation which corresponds to K43R mutation present in streptomycin-resistant Escherichia coli is also present...
June 2016: Journal of Biomolecular Structure & Dynamics
S Sehgal, S Mujtaba, D Gupta, R Aggarwal, R K Marwaha
INTRODUCTION: Epstein Barr virus (EBV) has a unique association with several human malignancies, especially lymphoproliferative disorders, mainly lymphomas in adults. There is paucity of data pertaining to EBV association with various cancers in India . OBJECTIVE: The study aims to investigate the association of EBV in childhood leukemia. MATERIAL AND METHODS: Patients attending pediatric oncology services of the referral center have been included in the study...
January 2010: Indian Journal of Pathology & Microbiology
Jue-Qiong Wang, Bao-An Chen, Jian Cheng, Wen-Lin Xu, Xin-Chen Sun
BACKGROUND & OBJECTIVE: 5-Bromotetrandrine (BrTet), a bromized derivative of tetrandrine (Tet), could effectively reverse P-glycoprotein (P-gp)-mediated multidrug resistance (MDR). This study was to compare the reversal effects of BrTet and Tet on MDR of human leukemia cell line K562/A02. METHODS: The effects of BrTet on the proliferation of K562 and K562/A02 cells were observed by MTT assay. The inhibitory effects of adriamycin (ADM) used alone or in combination with BrTet or Tet on the proliferation of K562 and K562/A02 cells were evaluated by MTT assay...
May 2008: Ai Zheng, Aizheng, Chinese Journal of Cancer
R kumar, R K Marwaha, A K Bhalla, M Gulati
OBJECTIVE: To determine the nutritional status and the extent of skeletal muscle wasting in children with acute lymphoblastic leukemia (ALL) at the time of diagnosis and after induction chemotherapy. DESIGN: Prospective observational study. SETTING: Tertiary care teaching hospital. METHODS: 25 new cases of ALL underwent somatometric measurements and ultrasonographic evaluation of skeletal muscle and subcutaneous fat at initial presentation and after completion of induction therapy...
July 2000: Indian Pediatrics
L H Stanker, G E Gallick, W S Kloetzer, E C Murphy, R B Arlinghaus
Antibody to a synthetic peptide (anti-C3 serum) with the predicted sequence of the C terminus of the Moloney murine sarcoma virus (strain 124) v-mos gene was used in immunoprecipitation experiments with cytoplasmic extracts of a clone of NRK cells infected with ts110 Moloney murine sarcoma virus, termed 6m2 cells. ts110 Moloney murine sarcoma virus codes for two viral proteins of 85,000 and 58,000 M(r), termed P85 and P58, respectively, in nonproducer 6m2 cells maintained at 33 degrees C. Anti-C3 serum specifically recognized [(3)H]leucine-labeled P85, but not P58, from infected cells maintained at 33 degrees C, whereas antiserum prepared against murine leukemia virus p12 recognized both proteins...
March 1983: Journal of Virology
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