Wangquan Ji, Ling Tao, Dong Li, Peiyu Zhu, Yuexia Wang, Yu Zhang, Liang Zhang, Shuaiyin Chen, Haiyan Yang, Yuefei Jin, Guangcai Duan
Abstract Coxsackievirus A19 (CVA19) is a member of Enterovirus (EV) C group in the Picornaviridae family. Recently, we reported a case of CVA19-infected hand, foot, and mouth disease (HFMD) for the first time. However, the current body of knowledge on the CVA19 infection, particularly the pathogenesis of encephalomyelitis and diarrhea is still very limited, due to the lack of suitable animal models. Here, we successfully established a CVA19 mouse model via oral route based on 7-day old ICR mice. Our results found the virus strain could directly infect the neurons, astrocytes of brain and motor neurons of spinal cord causing neurological complications, such as acute flaccid paralysis (AFP)...
February 3, 2023: Emerging Microbes & Infections