Durbadal Ojha, Collin S Hill, Shuntai Zhou, Alyssa B Evans, Jacqueline M Leung, Christine Schneider Lewis, Franck Amblard, Raymond F Schinazi, Ralph S Baric, Karin E Peterson, Ronald Swanstrom
A diverse group of RNA viruses including Rabies, Polio, La Crosse, West Nile, Zika, Nipah, Eastern and Western equine encephalitis, Venezuelan equine encephalitis, Japanese encephalitis, and tick-borne encephalitis viruses have the ability to gain access to and replicate in the central nervous system (CNS), causing severe neurological disease. Current treatment for these patients is generally limited to supportive care. To address the need for a generalizable antiviral, we utilized a strategy of mutagenesis to limit virus replication...
August 23, 2023: bioRxiv