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Helical tomotherapy

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https://www.readbyqxmd.com/read/29895020/locoregional-control-and-toxicity-in-head-and-neck-carcinoma-patients-following-helical-tomotherapy-delivered-intensity-modulated-radiation-therapy-compared-with-3d-crt-data
#1
REVIEW
Olalla Santa Cruz, Pelagia Tsoutsou, Cyril Castella, Kaouthar Khanfir, Sandro Anchisi, Salim Bouayed, Oscar Matzinger, Mahmut Ozsahin
OBJECTIVES: To assess the feasibility and efficacy of intensity-modulated radiation implemented with helical tomotherapy image-guided with daily megavoltage computed tomography for head and neck cancer. METHODS: Between May 2010 and May 2013, 72 patients were treated with curative intent. The median age was 64 years, with 57% undergoing definitive and 43% postoperative radiotherapy. Primary tumour sites were oral cavity (21%), oropharynx (26%), hypopharynx (20%), larynx (22%), and others (11%)...
June 12, 2018: Oncology
https://www.readbyqxmd.com/read/29876617/fdg-pet-derived-parameters-as-prognostic-tool-in-progressive-malignant-pleural-mesothelioma-treated-patients
#2
E Incerti, S Broggi, A Fodor, M Cuzzocrea, A M Samanes Gajate, P Mapelli, C Fiorino, I Dell'Oca, M Pasetti, M Cattaneo, R Calandrino, L Gianolli, N Di Muzio, Maria Picchio
PURPOSE: The value of FDG PET-derived parameters in predicting overall survival (OS), local relapse-free survival (LRFS) and distant relapse-free survival (DRFS) in treated patients with malignant pleural mesothelioma (MPM) was evaluated. METHODS: This retrospective evaluation included 55 MPM patients treated between March 2006 and February 2015 with FDG PET/CT-guided salvage helical tomotherapy (HTT) after previous surgery plus chemotherapy. Univariate Cox regression analysis was performed to assess the impact of the following FDG PET-derived parameters: biological target volume (BTV), mean and maximum standardized uptake values (SUVmean/max ), metabolic tumour volume (MTV) and total lesion glycolysis (TLG), measured using different uptake thresholds (40%, 50% and 60%)...
June 6, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29805760/the-use-of-helical-tomotherapy-in-the-treatment-of-early-stage-breast-cancer-indications-tolerance-efficacy-a-single-center-experience
#3
Alexandre Arsene-Henry, Jean-Philippe Foy, Magalie Robilliard, Hao-Ping Xu, Louis Bazire, Dominique Peurien, Philip Poortmans, Alain Fourquet, Youlia M Kirova
Purpose: to evaluate our experience in terms of local control, survival, adverse effects in patients treated by adjuvant helical tomotherapy (HT) for breast cancer (BC). Results: We studied 179 consecutive patients with 194 treated breasts with adjuvant HT. Median follow-up was 38.1 months. Median age was 53 years. Chemotherapy was administered to 83% of patients. All 133 hormone receptor positive tumours received hormonal therapy. As concurrent treatment, apart from trastuzumab monotherapy, 6 patients received systemic therapy concomitant to RT...
May 4, 2018: Oncotarget
https://www.readbyqxmd.com/read/29750173/radiotherapy-for-adult-medulloblastoma-evaluation-of-helical-tomotherapy-volumetric-intensity-modulated-arc-therapy-and-three-dimensional-conformal-radiotherapy-and-the-results-of-helical-tomotherapy-therapy
#4
Sun Zong-Wen, Yang Shuang-Yan, Du Feng-Lei, Cheng Xiao-Long, Li Qinglin, Chen Meng-Yuan, Hua Yong-Hong, Jin Ting, Hu Qiao-Ying, Chen Xiao-Zhong, Chen Yuan-Yuan, Chen Ming
Introduction: All adult medulloblastoma (AMB) patients should be treated with craniospinal irradiation (CSI) postoperatively. Because of the long irradiation range, multiple radiation fields must be designed for conventional radiotherapy technology. CSI can be completed in only one session with helical tomotherapy (HT). We evaluated the dose of HT, volumetric intensity modulated arc therapy (VMAT), and three-dimensional conformal radiotherapy (3D-CRT) of AMB and the results of 5 cases of AMB treated with HT...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29714086/a-dosimetric-evaluation-on-applying-rtog-based-and-ct-mri-based-delineation-methods-to-brachial-plexus-in-radiotherapy-of-nasopharyngeal-carcinoma-treated-with-helical-tomotherapy
#5
Chi-Him Li, Vincent Wc Wu, George Chiu
OBJECTIVE: In radiotherapy of nasopharyngeal carcinoma (NPC) patients, the brachial plexus (BP) situating at both sides of the neck are often irradiated to high dose. This study was to evaluate different BP delineation methods and analyse the dosimetric consequences when applying BP dose constraints in radiotherapy planning of NPC. METHODS: 15 NPC cases treated radically with helical tomotherapy were recruited. Apart from the original treatment plan (Plan A), two new plans (Plan B & C) with additional BP dose constraints were computed using the same planning computed tomography (CT) images, structures and planning parameters...
May 1, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29699582/effects-of-megavoltage-computed-tomographic-scan-methodology-on-setup-verification-and-adaptive-dose-calculation-in-helical-tomotherapy
#6
Jian Zhu, Tong Bai, Jiabing Gu, Ziwen Sun, Yumei Wei, Baosheng Li, Yong Yin
BACKGROUND: To evaluate the effect of pretreatment megavoltage computed tomographic (MVCT) scan methodology on setup verification and adaptive dose calculation in helical TomoTherapy. METHODS: Both anthropomorphic heterogeneous chest and pelvic phantoms were planned with virtual targets by TomoTherapy Physicist Station and were scanned with TomoTherapy megavoltage image-guided radiotherapy (IGRT) system consisted of six groups of options: three different acquisition pitches (APs) of 'fine', 'normal' and 'coarse' were implemented by multiplying 2 different corresponding reconstruction intervals (RIs)...
April 27, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29650302/raystation-external-beam-treatment-planning-system
#7
Dayna Bodensteiner
RaySearch Laboratories is a world leader in the field of advanced software and creator of the RayStation treatment planning system for radiation therapy. The aim with RayStation is to deliver an unmatched user experience and leading functionality. Unique features described here include multiatlas based autosegmentation for contouring, deformable registration with 2 different algorithms, multicriteria optimization, Plan Explorer, fallback planning, ultrafast computation speed, and 4-dimensional (4D) adaptive radiation therapy...
July 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29618353/efficacy-of-virtual-block-objects-in-reducing-the-lung-dose-in-helical-tomotherapy-planning-for-cervical-oesophageal-cancer-a-planning-study
#8
Makoto Ito, Hidetoshi Shimizu, Takahiro Aoyama, Hiroyuki Tachibana, Natsuo Tomita, Chiyoko Makita, Yutaro Koide, Daiki Kato, Tsuneo Ishiguchi, Takeshi Kodaira
BACKGROUND: Intensity-modulated radiotherapy is useful for cervical oesophageal carcinoma (CEC); however, increasing low-dose exposure to the lung may lead to radiation pneumonitis. Nevertheless, an irradiation technique that avoids the lungs has never been examined due to the high difficulty of dose optimization. In this study, we examined the efficacy of helical tomotherapy that can restrict beamlets passing virtual blocks during dose optimization computing (block plan) in reducing the lung dose...
April 4, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29607173/dosimetric-comparison-of-helical-tomotherapy-and-conventional-linac-based-x-knife-stereotactic-body-radiation-therapy-for-primary-lung-cancer-or-pulmonary-metastases
#9
Shuangshuang Li, Ju Yang, Juan Liu, Shanbao Gao, Baorui Liu, Jing Yan
Background: To compare helical tomotherapy (HT) with X-knife stereotactic body radiation therapy (HT-SBRT/X-SBRT) for primary or metastatic lung cancer regarding planning target volume (PTV) coverage, such as homogeneity index (HI), conformity index (CI) and dose-volume histogram (DVH) of organs at risk (OARs). Methods: We retrospectively analyzed 21 patients receiving definitive radiation treatment for non-small cell lung cancer (NSCLC) or pulmonary metastases at our institution between March 2015 and October 2016...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29599376/effectiveness-and-safety-of-tissue-expander-for-adjuvant-helical-tomotherapy-in-curatively-resected-retroperitoneal-sarcoma
#10
Jeong Il Yu, DO Hoon Lim, Hee Chul Park, Sang Hoon Jung, Seong Jin Jeon, Heerim Nam, Bokyoung Kim, Sung-Joo Kim, Jae Berm Park
BACKGROUND/AIM: We investigated the effectiveness and safety of using a tissue expander (TE) for adjuvant helical tomotherapy (HT) for curatively resected retroperitoneal sarcoma (RPS). MATERIALS AND METHODS: This study was conducted with 60 RPS patients who underwent curative resection with or without TE insertion followed by HT from June 2009 to December 2016. Among the patients, TE was inserted in 37 (61.7%). The quality of TE insertion was evaluated. Median follow-up after surgery was 19...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29580934/3d-treatment-planning-on-helical-tomotherapy-delivery-system
#11
REVIEW
Cheng B Saw, Leah Katz, Carol Gillette, Lawrence Koutcher
The helical tomotherapy is a technologically advanced radiation dose delivery system designed to perform intensity-modulated radiation therapy (IMRT). It is mechanistically unique, based on a small 6-MV linear accelerator mounted on a ring gantry that rotates around the patient while the patient moves through a bore, ultimately yielding a helical path of radiation dose delivery. The helical pattern of dose delivery differentiated tomotherapy from other contemporary radiation therapy systems at the time of its inception...
July 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29505510/efficacy-and-safety-of-image-guidance-radiotherapy-by-helical-tomotherapy-in-patients-with-lung-cancer
#12
Xiang-Ru Chen, Jia-Nan Dong, Fan Zhang, Tian-Ling Yao
This study aimed to explore the efficacy and toxicity of image-guided stereotactic body radiotherapy (IGSBR) by helical tomotherapy in patients with lung cancer among Chinese Han population.A total of 21 patients with stage I lung cancer were included. They received a total of 60 Gy factions IGSBR. The outcomes included complete response (CR), partial response (PR), stable disease (SD), progress disease (PD), overall response rate (ORR), and overall survival (OS). In addition, toxicities were also recorded in this study...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29482775/total-body-irradiation-in-allogeneic-bone-marrow-transplantation-conditioning-regimens-a-review
#13
REVIEW
Adrien Paix, Delphine Antoni, Waisse Waissi, Marie-Pierre Ledoux, Karin Bilger, Luc Fornecker, Georges Noel
Hematologic malignancies may require, at one point during their treatment, allogeneic bone marrow transplantation. Total body irradiation combined with chemotherapy or radiomimetic used in allogeneic bone marrow transplantation is known to be very toxic. Total body irradiation (TBI) induces immunosuppression to prevent the rejection of donor marrow. TBI is also used to eradicate malignant cells and is in sanctuary organs that are not reached by chemotherapy drugs. TBI has evolved since its introduction in the late fifties, but acute and late toxicities remain...
March 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29474098/comparing-four-radiotherapy-techniques-for-treating-the-chest-wall-plus-levels-iii-iv-draining-nodes-after-breast-reconstruction
#14
Valentina Lancellotta, Martina Iacco, Elisabetta Perrucci, Lorenzo Falcinelli, Claudio Zucchetti, Berardino de Bari, Simonetta Saldi, Cynthia Aristei
OBJECTIVE: To compare the dosimetric outcomes of four radiotherapy (RT) techniques for treating the chest wall plus draining nodes after mastectomy and breast reconstruction. METHODS: Three-dimensional conformal radiotherapy, linac-based intensity modulated RT, helical tomotherapy (HT) and direct tomotherapy treatments were planned for 40 breast cancer patients. Dose prescription was 50 Gy. Plans were compared in terms of doses to the planning target volume, organs at risk and the homogeneity index...
March 19, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29455424/hypo-fractionated-stereotactic-radiation-therapy-for-lung-malignancies-by-means-of-helical-tomotherapy-report-of-feasibility-by-a-single-center-experience
#15
Vanessa Figlia, Rosario Mazzola, Francesco Cuccia, Filippo Alongi, Gianluca Mortellaro, Daniela Cespuglio, Teresa Cucchiara, Giuseppina Iacoviello, Vito Valenti, Massimo Molino, Francesco Verderame, Domenica Matranga, Antonio Lo Casto, Giuseppe Ferrera
BACKGROUND: Several experiences in the literature report SBRT as an effective treatment option for medically inoperable early stage non-small cell lung cancer (NSCLC) and oligometastatic disease. The optimal fractionation schedules and total dose remain controversial. In this study, we evaluated the safety in terms of toxicity and efficacy of using of 8-10 fractions schedules with Helical Tomotherapy (HT) for primary and metastatic lung lesions. METHODS: Between March 2014 and May 2016, a total of 39 patients (median age 72 years, range 26-91) were treated with HT-SBRT for malignant lung lesions: 22 patients with early stage NSCLC, 17 with oligometastases...
June 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29442173/hypofractionated-postmastectomy-radiotherapy-with-helical-tomotherapy-in-patients-with-immediate-breast-reconstruction-dosimetric-results-and-acute-intermediate-toxicity-evaluation
#16
Roberto Orecchia, Damaris Patricia Rojas, Federica Cattani, Rosalinda Ricotti, Luigi Santoro, Anna Morra, Raffaella Cambria, Rosa Luraschi, Samantha Dicuonzo, Sara Ronchi, Alessia Surgo, Veronica Dell' Acqua, Paolo Veronesi, Francesca De Lorenzi, Cristiana Fodor, Maria Cristina Leonardi, Barbara Alicja Jereczek-Fossa
The aim of this study was to evaluate the dosimetry and toxicity of hypofractionation in postmastectomy radiotherapy (PMRT) with intensity-modulated radiotherapy (IMRT) in breast cancer (BC) patients. Stage II-III BC patients with implant-based immediate breast reconstruction received PMRT to the chest wall (CW) and to the infra/supraclavicular nodal region (NR) using a 15-fraction schedule (2.67 Gy/fraction) and helical IMRT (Tomotherapy® System, Accuray Incorporated, Sunnyvale, CA). A score was assigned to each treatment plan in terms of planning target volume (PTV) coverage of CW and NR and the sparing of the organs at risk (OARs)...
February 13, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29441419/modern-intensity-modulated-radiotherapy-with-image-guidance-allows-low-toxicity-rates-and-good-local-control-in-chemoradiotherapy-for-anal-cancer-patients
#17
Berardino De Bari, Laëtitia Lestrade, Alessandra Franzetti-Pellanda, Raphael Jumeau, Maira Biggiogero, Melpomeni Kountouri, Oscar Matzinger, Raymond Miralbell, Jean Bourhis, Mahmut Ozsahin, Thomas Zilli
PURPOSE: To report outcomes of a population of anal cancer patients treated with modern intensity-modulated radiotherapy and daily image-guided radiotherapy techniques. METHODS: We analyzed data of 155 patients consecutively treated with intensity-modulated radiotherapy +/- chemotherapy in three radiotherapy departments. One hundred twenty-two patients presented a stage II-IIIA disease. Chemotherapy was administered in 138 patients, mainly using mitomycin C and 5-fluorouracil (n = 81)...
April 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29417728/comparison-of-four-techniques-for-spine-stereotactic-body-radiotherapy-dosimetric-and-efficiency-analysis
#18
Saif Aljabab, Balamurugan Vellayappan, Eric Vandervoort, Jamie Bahm, Robert Zohr, John Sinclair, Jean-Michel Caudrelier, Janos Szanto, Shawn Malone
PURPOSE: The aim of this study is to compare the dosimetric differences between four techniques for spine stereotactic body radiotherapy (SBRT): CyberKnife (CK), volumetric modulated arc therapy (VMAT), and helical tomotherapy (HT) with dynamic jaws (HT-D) and fixed jaws (HT-F). MATERIALS/METHODS: Data from 10 patients were utilized. All patients were planned for 24 Gy in two fractions, with the primary objectives being: (a) restricting the maximum dose to the cord to ≤ 17 Gy and/or cauda equina to ≤ 20 Gy, and (b) to maximize the clinical target volume (CTV) to receive the prescribed dose...
March 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29405307/feasibility-of-real-time-motion-management-with-helical-tomotherapy
#19
Eric Schnarr, Matt Beneke, Dylan Casey, Edward Chao, Jonathan Chappelow, Andrea Cox, Doug Henderson, Petr Jordan, Etienne Lessard, Dan Lucas, Andriy Myronenko, Calvin Maurer
PURPOSE: This study investigates the potential application of image-based motion tracking and real-time motion correction to a helical tomotherapy system. METHODS: A kV x-ray imaging system was added to a helical tomotherapy system, mounted 90 degrees offset from the MV treatment beam, and an optical camera system was mounted above the foot of the couch. This experimental system tracks target motion by acquiring an x-ray image every few seconds during gantry rotation...
April 2018: Medical Physics
https://www.readbyqxmd.com/read/29395854/total-body-irradiation-using-helical-tomotherapy-%C3%A2-treatment-technique-dosimetric-results-and-initial-clinical-experience
#20
V Sarradin, L Simon, A Huynh, J Gilhodes, T Filleron, F Izar
PURPOSE: Helical TomoTherapy® allows precise and homogeneous tumour coverage and excellent sparing of organs at risk. We present here our treatment technique, dosimetric results, and our first clinical data for patients receiving total body irradiation as part of the conditioning regimen before hematopoietic stem cell transplantation. PATIENTS AND METHODS: The cohort consisted of 11 patients who were treated in our institution between August 2014 and January 2016...
February 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
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