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Helical tomotherapy

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https://www.readbyqxmd.com/read/29650302/raystation-external-beam-treatment-planning-system
#1
Dayna Bodensteiner
RaySearch Laboratories is a world leader in the field of advanced software and creator of the RayStation treatment planning system for radiation therapy. The aim with RayStation is to deliver an unmatched user experience and leading functionality. Unique features described here include multiatlas based autosegmentation for contouring, deformable registration with 2 different algorithms, multicriteria optimization, Plan Explorer, fallback planning, ultrafast computation speed, and 4-dimensional (4D) adaptive radiation therapy...
April 9, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29618353/efficacy-of-virtual-block-objects-in-reducing-the-lung-dose-in-helical-tomotherapy-planning-for-cervical-oesophageal-cancer-a-planning-study
#2
Makoto Ito, Hidetoshi Shimizu, Takahiro Aoyama, Hiroyuki Tachibana, Natsuo Tomita, Chiyoko Makita, Yutaro Koide, Daiki Kato, Tsuneo Ishiguchi, Takeshi Kodaira
BACKGROUND: Intensity-modulated radiotherapy is useful for cervical oesophageal carcinoma (CEC); however, increasing low-dose exposure to the lung may lead to radiation pneumonitis. Nevertheless, an irradiation technique that avoids the lungs has never been examined due to the high difficulty of dose optimization. In this study, we examined the efficacy of helical tomotherapy that can restrict beamlets passing virtual blocks during dose optimization computing (block plan) in reducing the lung dose...
April 4, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29607173/dosimetric-comparison-of-helical-tomotherapy-and-conventional-linac-based-x-knife-stereotactic-body-radiation-therapy-for-primary-lung-cancer-or-pulmonary-metastases
#3
Shuangshuang Li, Ju Yang, Juan Liu, Shanbao Gao, Baorui Liu, Jing Yan
Background: To compare helical tomotherapy (HT) with X-knife stereotactic body radiation therapy (HT-SBRT/X-SBRT) for primary or metastatic lung cancer regarding planning target volume (PTV) coverage, such as homogeneity index (HI), conformity index (CI) and dose-volume histogram (DVH) of organs at risk (OARs). Methods: We retrospectively analyzed 21 patients receiving definitive radiation treatment for non-small cell lung cancer (NSCLC) or pulmonary metastases at our institution between March 2015 and October 2016...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29599376/effectiveness-and-safety-of-tissue-expander-for-adjuvant-helical-tomotherapy-in-curatively-resected-retroperitoneal-sarcoma
#4
Jeong Il Yu, DO Hoon Lim, Hee Chul Park, Sang Hoon Jung, Seong Jin Jeon, Heerim Nam, Bokyoung Kim, Sung-Joo Kim, Jae Berm Park
BACKGROUND/AIM: We investigated the effectiveness and safety of using a tissue expander (TE) for adjuvant helical tomotherapy (HT) for curatively resected retroperitoneal sarcoma (RPS). MATERIALS AND METHODS: This study was conducted with 60 RPS patients who underwent curative resection with or without TE insertion followed by HT from June 2009 to December 2016. Among the patients, TE was inserted in 37 (61.7%). The quality of TE insertion was evaluated. Median follow-up after surgery was 19...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29580934/3d-treatment-planning-on-helical-tomotherapy-delivery-system
#5
REVIEW
Cheng B Saw, Leah Katz, Carol Gillette, Lawrence Koutcher
The helical tomotherapy is a technologically advanced radiation dose delivery system designed to perform intensity-modulated radiation therapy (IMRT). It is mechanistically unique, based on a small 6-MV linear accelerator mounted on a ring gantry that rotates around the patient while the patient moves through a bore, ultimately yielding a helical path of radiation dose delivery. The helical pattern of dose delivery differentiated tomotherapy from other contemporary radiation therapy systems at the time of its inception...
March 23, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29505510/efficacy-and-safety-of-image-guidance-radiotherapy-by-helical-tomotherapy-in-patients-with-lung-cancer
#6
Xiang-Ru Chen, Jia-Nan Dong, Fan Zhang, Tian-Ling Yao
This study aimed to explore the efficacy and toxicity of image-guided stereotactic body radiotherapy (IGSBR) by helical tomotherapy in patients with lung cancer among Chinese Han population.A total of 21 patients with stage I lung cancer were included. They received a total of 60 Gy factions IGSBR. The outcomes included complete response (CR), partial response (PR), stable disease (SD), progress disease (PD), overall response rate (ORR), and overall survival (OS). In addition, toxicities were also recorded in this study...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29482775/total-body-irradiation-in-allogeneic-bone-marrow-transplantation-conditioning-regimens-a-review
#7
REVIEW
Adrien Paix, Delphine Antoni, Waisse Waissi, Marie-Pierre Ledoux, Karin Bilger, Luc Fornecker, Georges Noel
Hematologic malignancies may require, at one point during their treatment, allogeneic bone marrow transplantation. Total body irradiation combined with chemotherapy or radiomimetic used in allogeneic bone marrow transplantation is known to be very toxic. Total body irradiation (TBI) induces immunosuppression to prevent the rejection of donor marrow. TBI is also used to eradicate malignant cells and is in sanctuary organs that are not reached by chemotherapy drugs. TBI has evolved since its introduction in the late fifties, but acute and late toxicities remain...
March 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29474098/comparing-four-radiotherapy-techniques-for-treating-the-chest-wall-plus-levels-iii-iv-draining-nodes-after-breast-reconstruction
#8
Valentina Lancellotta, Martina Iacco, Elisabetta Perrucci, Lorenzo Falcinelli, Claudio Zucchetti, Berardino de Bari, Simonetta Saldi, Cynthia Aristei
OBJECTIVE: To compare the dosimetric outcomes of four radiotherapy (RT) techniques for treating the chest wall plus draining nodes after mastectomy and breast reconstruction. METHODS: Three-dimensional conformal radiotherapy (3DCRT), linac-based intensity modulated radiotherapy, helical tomotherapy (HT) and direct tomotherapy (DT) treatments were planned for 40 breast cancer patients. Dose prescription was 50 Gy. Plans were compared in terms of doses to the planning target volume, organs at risk (OARs) and the homogeneity index (HI)...
February 23, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29455424/hypo-fractionated-stereotactic-radiation-therapy-for-lung-malignancies-by-means-of-helical-tomotherapy-report-of-feasibility-by-a-single-center-experience
#9
Vanessa Figlia, Rosario Mazzola, Francesco Cuccia, Filippo Alongi, Gianluca Mortellaro, Daniela Cespuglio, Teresa Cucchiara, Giuseppina Iacoviello, Vito Valenti, Massimo Molino, Francesco Verderame, Domenica Matranga, Antonio Lo Casto, Giuseppe Ferrera
BACKGROUND: Several experiences in the literature report SBRT as an effective treatment option for medically inoperable early stage non-small cell lung cancer (NSCLC) and oligometastatic disease. The optimal fractionation schedules and total dose remain controversial. In this study, we evaluated the safety in terms of toxicity and efficacy of using of 8-10 fractions schedules with Helical Tomotherapy (HT) for primary and metastatic lung lesions. METHODS: Between March 2014 and May 2016, a total of 39 patients (median age 72 years, range 26-91) were treated with HT-SBRT for malignant lung lesions: 22 patients with early stage NSCLC, 17 with oligometastases...
February 17, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29442173/hypofractionated-postmastectomy-radiotherapy-with-helical-tomotherapy-in-patients-with-immediate-breast-reconstruction-dosimetric-results-and-acute-intermediate-toxicity-evaluation
#10
Roberto Orecchia, Damaris Patricia Rojas, Federica Cattani, Rosalinda Ricotti, Luigi Santoro, Anna Morra, Raffaella Cambria, Rosa Luraschi, Samantha Dicuonzo, Sara Ronchi, Alessia Surgo, Veronica Dell' Acqua, Paolo Veronesi, Francesca De Lorenzi, Cristiana Fodor, Maria Cristina Leonardi, Barbara Alicja Jereczek-Fossa
The aim of this study was to evaluate the dosimetry and toxicity of hypofractionation in postmastectomy radiotherapy (PMRT) with intensity-modulated radiotherapy (IMRT) in breast cancer (BC) patients. Stage II-III BC patients with implant-based immediate breast reconstruction received PMRT to the chest wall (CW) and to the infra/supraclavicular nodal region (NR) using a 15-fraction schedule (2.67 Gy/fraction) and helical IMRT (Tomotherapy®System, Accuray Incorporated, Sunnyvale, CA). A score was assigned to each treatment plan in terms of planning target volume (PTV) coverage of CW and NR and the sparing of the organs at risk (OARs)...
February 13, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29441419/modern-intensity-modulated-radiotherapy-with-image-guidance-allows-low-toxicity-rates-and-good-local-control-in-chemoradiotherapy-for-anal-cancer-patients
#11
Berardino De Bari, Laëtitia Lestrade, Alessandra Franzetti-Pellanda, Raphael Jumeau, Maira Biggiogero, Melpomeni Kountouri, Oscar Matzinger, Raymond Miralbell, Jean Bourhis, Mahmut Ozsahin, Thomas Zilli
PURPOSE: To report outcomes of a population of anal cancer patients treated with modern intensity-modulated radiotherapy and daily image-guided radiotherapy techniques. METHODS: We analyzed data of 155 patients consecutively treated with intensity-modulated radiotherapy +/- chemotherapy in three radiotherapy departments. One hundred twenty-two patients presented a stage II-IIIA disease. Chemotherapy was administered in 138 patients, mainly using mitomycin C and 5-fluorouracil (n = 81)...
April 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29417728/comparison-of-four-techniques-for-spine-stereotactic-body-radiotherapy-dosimetric-and-efficiency-analysis
#12
Saif Aljabab, Balamurugan Vellayappan, Eric Vandervoort, Jamie Bahm, Robert Zohr, John Sinclair, Jean-Michel Caudrelier, Janos Szanto, Shawn Malone
PURPOSE: The aim of this study is to compare the dosimetric differences between four techniques for spine stereotactic body radiotherapy (SBRT): CyberKnife (CK), volumetric modulated arc therapy (VMAT), and helical tomotherapy (HT) with dynamic jaws (HT-D) and fixed jaws (HT-F). MATERIALS/METHODS: Data from 10 patients were utilized. All patients were planned for 24 Gy in two fractions, with the primary objectives being: (a) restricting the maximum dose to the cord to ≤ 17 Gy and/or cauda equina to ≤ 20 Gy, and (b) to maximize the clinical target volume (CTV) to receive the prescribed dose...
February 7, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29405307/feasibility-of-real-time-motion-management-with-helical-tomotherapy
#13
Eric Schnarr, Matt Beneke, Dylan Casey, Edward Chao, Jonathan Chappelow, Andrea Cox, Doug Henderson, Petr Jordan, Etienne Lessard, Dan Lucas, Andriy Myronenko, Calvin Maurer
PURPOSE: This study investigates the potential application of image-based motion tracking and real-time motion correction to a helical tomotherapy system. METHODS: A kV X ray imaging system was added to a helical tomotherapy system, mounted 90 degrees offset from the MV treatment beam, and an optical camera system was mounted above the foot of the couch. This experimental system tracks target motion by acquiring an X ray image every few seconds during gantry rotation...
February 5, 2018: Medical Physics
https://www.readbyqxmd.com/read/29395854/total-body-irradiation-using-helical-tomotherapy-%C3%A2-treatment-technique-dosimetric-results-and-initial-clinical-experience
#14
V Sarradin, L Simon, A Huynh, J Gilhodes, T Filleron, F Izar
PURPOSE: Helical TomoTherapy® allows precise and homogeneous tumour coverage and excellent sparing of organs at risk. We present here our treatment technique, dosimetric results, and our first clinical data for patients receiving total body irradiation as part of the conditioning regimen before hematopoietic stem cell transplantation. PATIENTS AND METHODS: The cohort consisted of 11 patients who were treated in our institution between August 2014 and January 2016...
February 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29372290/patient-positioning-in-head-and-neck-cancer-setup-variations-and-safety-margins-in-helical-tomotherapy
#15
Christina Leitzen, Timo Wilhelm-Buchstab, Thomas Müdder, Martina Heimann, David Koch, Christopher Schmeel, Birgit Simon, Sabina Stumpf, Susanne Vornholt, Stephan Garbe, Fred Röhner, Felix Schoroth, Hans Heinz Schild, Heinrich Schüller
OBJECTIVE: To evaluate the interfractional variations of patient positioning during intensity-modulated radiotherapy (IMRT) with helical tomotherapy in head and neck cancer and to calculate the required safety margins (sm) for bony landmarks resulting from the necessary table adjustments. MATERIALS AND METHODS: In all, 15 patients with head and neck cancer were irradiated using the Hi-Art II tomotherapy system between April and September 2016. Before therapy sessions, patient position was frequently checked by megavolt computed tomography (MV-CT)...
January 25, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29350548/use-of-helical-tomotherapy-in-locally-advanced-and-or-metastatic-breast-cancer-for-locoregional-treatment
#16
Laura Thery, Alexandre Arsene-Henry, Susan Carroll, Dominique Peurien, Louis Bazire, Magalie Robilliard, Alain Fourquet, Youlia M Kirova
OBJECTIVE: Helical tomotherapy (HT) is a new promising tool whose use remains to be studied. This work assesses its impact for local irradiation in terms of side effects, as well as tumour control in locally advanced (LABC) and metastatic breast cancer (MBC). METHODS: We retrospectively reviewed data of 66 patients with LABC and MBC. Patients received standard fractionated radiotherapy by HT, with or without concurrent systemic treatment. RESULTS: The median age was 60 years (28-77)...
February 5, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29333123/evaluation-of-deformable-image-registration-dir-methods-for-dose-accumulation-in-nasopharyngeal-cancer-patients-during-radiotherapy
#17
Wannapha Nobnop, Imjai Chitapanarux, Hudsaleark Neamin, Somsak Wanwilairat, Vicharn Lorvidhaya, Taweap Sanghangthum
Introduction: Deformable image registration (DIR) is used to modify structures according to anatomical changes for observing the dosimetric effect. In this study, megavoltage computed tomography (MVCT) images were used to generate cumulative doses for nasopharyngeal cancer (NPC) patients by various DIR methods. The performance of the multiple DIR methods was analysed, and the impact of dose accumulation was assessed. Patients and methods: The study consisted of five NPC patients treated with a helical tomotherapy unit...
December 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/29330392/haploidentical-hematopoietic-sct-using-helical-tomotherapy-for-total-body-irradiation-and-targeted-dose-boost-in-patients-with-high-risk-refractory-acute-lymphoblastic-leukemia
#18
Zujun Jiang, Junsong Jia, Chunyan Yue, Yan Pang, Zenghui Liu, Ling Ouyang, Hongbo Li, Jinjian Zhang, Ting Wen, Jing Li, Zhiqiang Li, Yan Wang, Yang Xiao, Haowen Xiao
A novel conditioning regimen using helical tomotherapy (HT) was developed to deliver 10 Gy for total body irradiation (TBI) and simultaneously augment dose to 12 Gy for targeted dose boost to total marrow, central nervous system leukemia, and extramedullary disease sites in patients with high-risk or relapsed/refractory acute lymphoblastic leukemia (ALL) receiving haploidentical allogeneic hematopoietic stem cell transplantation (allo-HSCT). Fourteen patients were included, eight of these patients were in first complete remission (CR1), one was in CR2, one had a partial response and four patients had refractory disease at transplantation...
April 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29277799/long-term-outcomes-of-a-dose-reduction-trial-to-decrease-late-gastrointestinal-toxicity-in-patients-with-prostate-cancer-receiving-soft-tissue-matched-image-guided-intensity-modulated-radiotherapy
#19
Naomi Sasaki, Hideya Yamazaki, Daisuke Shimizu, Gen Suzuki, Koji Masui, Satoaki Nakamura, Haruumi Okabe, Tatsuyuki Nishikawa, Ken Yoshida
BACKGROUND/AIM: We experienced an unexpected high incidence of gastrointestinal (GI) toxicity in patients undergoing image-guided intensity-modulated radiotherapy (IG-IMRT) using helical tomotherapy in our initial 2.2 Gy/fraction schedule for prostate cancer; hence, a dose-reduction trial from 2.2 Gy to 2 Gy/fraction was conducted using modified planning target volume (PTV) contouring. PATIENTS AND METHODS: We compared 130 patients treated using 2.2 Gy/fraction (Group A) and 144 treated using the 2 Gy/fraction (Group B) with modified PTV (excluding rectal volume) with a median follow-up period of 62 months...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29207865/prognostic-value-of-nodal-suvmax-of-18f-fdg-pet-ct-in-nasopharyngeal-carcinoma-treated-with-intensity-modulated-radiotherapy
#20
So Jung Lee, Chul-Seoung Kay, Yeon-Sil Kim, Seok Hyun Son, Myungsoo Kim, Sea-Won Lee, Hye Jin Kang
PURPOSE: To investigate the predictive role of maximum standardized uptake value (SUVmax) of 2-[18F]fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in nasopharyngeal cancer patients treated with intensity-modulated radiotherapy (IMRT). MATERIALS AND METHODS: Between October 2006 and April 2016, 53 patients were treated with IMRT in two institutions and their PET/CT at the time of diagnosis was reviewed. The SUVmax of their nasopharyngeal lesions and metastatic lymph nodes (LN) was recorded...
December 2017: Radiation Oncology Journal
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