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Helical tomotherapy

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https://www.readbyqxmd.com/read/28314468/constraints-for-symptomatic-radiation-pneumonitis-of-helical-tomotherapy-hypofractionated-simultaneous-multitarget-radiotherapy-for-pulmonary-metastasis-from-hepatocellular-carcinoma
#1
Genlai Lin, Han Xiao, Zhaochong Zeng, Zhiyong Xu, Jian He, Taiwei Sun, Jin Liu, Genwu Guo, Weixing Ji, Yong Hu
BACKGROUND AND PURPOSE: This study was aimed to identify the clinical and dosimetric parameters that predict symptomatic radiation pneumonitis (SRP, radiation pneumonitis≥2 grade) in patients with pulmonary metastasis from hepatocellular carcinoma (HCC) after helical tomotherapy (HT) hypofractionated simultaneous multitarget radiotherapy. MATERIALS AND METHODS: 62 patients with 407 pulmonary metastases from HCC were consecutively treated with HT. The median radiation dose was a 49...
March 14, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28297444/surface-imaging-laser-positioning-or-volumetric-imaging-for-breast-cancer-with-nodal-involvement-treated-by-helical-tomotherapy
#2
Frederik Crop, David Pasquier, Amandine Baczkiewic, Julie Doré, Lena Bequet, Emeline Steux, Anne Gadroy, Jacqueline Bouillon, Clement Florence, Laurence Muszynski, Mathilde Lacour, Eric Lartigau
A surface imaging system, Catalyst (C-Rad), was compared with laser-based positioning and daily mega voltage computed tomography (MVCT) setup for breast patients with nodal involvement treated by helical TomoTherapy. Catalyst-based positioning performed better than laser-based positioning. The respective modalities resulted in a standard deviation (SD), 68% confidence interval (CI) of positioning of left-right, craniocaudal, anterior-posterior, roll: 2.4 mm, 2.7 mm, 2.4 mm, 0.9° for Catalyst positioning, and 6...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297441/comprehensive-dosimetric-planning-comparison-for-early-stage-non-small-cell-lung-cancer-with-sabr-fixed-beam-imrt-versus-vmat-versus-tomotherapy
#3
Ilma Xhaferllari, Omar El-Sherif, Stewart Gaede
Volumetric-modulated arc therapy (VMAT) is emerging as a leading technology in treating early-stage, non-small cell lung cancer (NSCLC) with stereotactic ablative radiotherapy (SABR). However, two other modalities capable of delivering intensity-modulated radiation therapy (IMRT) include fixed-beam and helical TomoTherapy (HT). This study aims to provide an extensive dosimetric comparison among these various IMRT techniques for treating early-stage NSCLC with SABR. Ten early-stage NSCLC patients were retrospectively optimized using three fixed-beam techniques via nine to eleven beams (high and low modulation step-and-shoot (SS), and sliding window (SW)), two VMAT techniques via two partial arcs (SmartArc (SA) and RapidArc (RA)), and three HT techniques via three different fan beam widths (1 cm, 2...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28291935/helical-tomotherapy-to-linac-plan-conversion-utilizing-raystation-fallback-planning
#4
Xin Zhang, Jose Penagaricano, Ganesh Narayanasamy, Peter Corry, TianXiao Liu, Maraboyina Sanjay, Nava Paudel, Steven Morrill
RaySearch RayStation Fallback (FB) planning module can generate an equivalent backup radiotherapy treatment plan facilitating treatment on other linear accelerators. FB plans were generated from the RayStation FB module by simulating the original plan target and organ at risk (OAR) dose distribution and delivered in various backup linear accelerators. In this study, helical tomotherapy (HT) backup plans used in Varian TrueBeam linear accelerator were generated with the RayStation FB module. About 30 patients, 10 with lung cancer, 10 with head and neck (HN) cancer, and 10 with prostate cancer, who were treated with HT, were included in this study...
January 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28270323/toxicity-and-early-clinical-outcomes-in-cervical-cancer-following-extended-field-helical-tomotherapy-to-para-aortic-lymph-nodes
#5
E Jouglar, L Thomas, A de la Rochefordière, G Noël, M Le Blanc-Onfroy, G Delpon, L Campion, M-A Mahé
PURPOSE: To evaluate toxicity and early disease outcome among patients treated for cervical cancer with extended-field helical tomotherapy to the para-aortic nodes. PATIENTS AND METHODS: Thirty-eight patients (International Federation of Gynecology and Obstetrics [FIGO] stage IB2-IVA) from four institutions received extended-field helical tomotherapy and were retrospectively evaluated. All had nodal disease. Para-aortic lymph nodes were involved in 31 patients. Patients were assessed for toxicity using version 4 of the National Cancer Institute's common terminology criteria for adverse events...
December 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28270018/therapeutic-benefits-in-grid-irradiation-on-tomotherapy-for-bulky-radiation-resistant-tumors
#6
Ganesh Narayanasamy, Xin Zhang, Ali Meigooni, Nava Paudel, Steven Morrill, Sanjay Maraboyina, Loverd Peacock, Jose Penagaricano
INTRODUCTION: Spatially fractionated radiation therapy (SFRT or grid therapy) has proven to be effective in management of bulky tumors. The aim of this project is to study the therapeutic ratio (TR) of helical Tomotherapy (HT)-based grid therapy using linear-quadratic cell survival model. MATERIAL AND METHODS: HT-based grid (or HT-GRID) plan was generated using a patient-specific virtual grid pattern of high-dose cylindrical regions using MLCs. TR was defined as the ratio of normal tissue surviving fraction (SF) under HT-GRID irradiation to an open debulking field of an equivalent dose that result in the same tumor cell SF...
March 8, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28256158/treatment-outcomes-and-patterns-of-radiologic-appearance-after-hypofractionated-image-guided-radiotherapy-delivered-with-helical-tomotherapy-hht-for-lung-tumours
#7
Stefano Arcangeli, Lorenzo Falcinelli, Stefano Bracci, Alessandro Greco, Alessia Monaco, Jessica Dognini, Cinzia Chiostrini, Rita Bellavita, Cynthia Aristei, Vittorio Donato
OBJECTIVE: To evaluate treatment outcomes and patterns of CT lung injury after hypofractionated image-guided radiotherapy delivered with helical tomotherapy (HHT) in a series of inoperable lung lesions. METHODS: 68 patients who were medically inoperable (69 lesions) without evidence of viable extrathoracic disease were included. Dose prescription was driven by tumour location (hilar/pericentral vs peripheral) and/or target volume. 52% of the lesions received a biological equivalent dose (BED10) ≥100 Gy...
March 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28255431/helical-tomotherapy-for-duodenal-adenocarcinoma-in-an-elderly-patient-a-case-report
#8
Valentina Lancellotta, Giuseppe Russo, Marco Lupattelli, Martina Iacco, Elisabetta Perrucci, Claudio Zucchetti, Lorenzo Falcinelli, Cynthia Aristei
To evaluate the efficacy and feasibility of external beam radiotherapy (EBRT) for duodenal adenocarcinoma in an 84-year-old female who underwent EBRT (2.2 Gy/d for a total dose of 46.2 Gy) using helical tomotherapy (HT). Toxicity was evaluated on the National Cancer Institute's common toxicity criteria (CTCAE 3.0). The patient completed the treatment without G3-G4 toxicity. After 22-mo follow-up, she is alive and well, in complete remission with no late side effects. HT seems to be feasible and effective for duodenal adenocarcinoma in old to very old patients...
February 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28214420/prevention-of-radiotherapy-induced-neurocognitive-dysfunction-in-survivors-of-paediatric-brain-tumours-the-potential-role-of-modern-imaging-and-radiotherapy-techniques
#9
REVIEW
Thankamma Ajithkumar, Stephen Price, Gail Horan, Amos Burke, Sarah Jefferies
Neurocognitive dysfunction is the leading cause of reduced quality of life in long-term survivors of paediatric brain tumours. Radiotherapy is one of the main contributors to neurocognitive sequelae. Current approaches for prevention and reduction of neurocognitive dysfunction include avoidance of radiotherapy in young children and reduction of the radiotherapy dose and volume of brain irradiated. Substantial advances have been made in brain imaging, especially with functional imaging and fibre tracking with the use of diffusion tensor imaging...
February 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28199977/pre-radiotherapy-neutrophil-to-lymphocyte-ratio-as-an-independent-prognostic-factor-in-patients-with-locally-advanced-hepatocellular-carcinoma-treated-with-radiotherapy
#10
Seok Hyun Son, Eun Young Park, Hee Hyun Park, Chul Seung Kay, Hong Seok Jang
We aimed to investigate the pre-radiotherapy neutrophil-to-lymphocyte ratio (prNLR) as a prognostic factor in patients with locally advanced hepatocellular carcinoma (HCC) treated with radiotherapy (RT), and to determine the optimal cut-off value for prNLR. We retrospectively evaluated 56 patients with locally advanced HCC treated with RT (helical tomotherapy) between March 2006 and February 2012. The optimal cut-off value was determined by using a maximally selected log-rank test. Prognostic factors that influence the local progression-free survival (PFS) and overall survival (OS) were evaluated...
February 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28159930/compared-planning-dosimetry-of-tomo-vmat-and-imrt-in-rectal-cancer-with-different-simulated-positions
#11
Jang-Chun Lin, Jo-Ting Tsai, Li-Jhen Chen, Ming-Hsien Li, Wei-Hsiu Liu
OBJECTIVES: To compare treatment plans for helical tomotherapy (TOMO), volumetric modulated arc therapy (VMAT) and intensity-modulated radiotherapy (IMRT) for locally advanced rectal cancer (LARC). MATERIALS AND METHODS: This retrospective study from December 2010 to June 2013 included 20 patients with LARC who received neoadjuvant concurrent chemoradiotherapy (CCRT) with radiation doses of greater than 50.4 Gy. Dosimetric quality was evaluated based on doses to organs at risk (OARs), including small bowel, urinary bladder and bilateral femoral head, over the same coverage of the clinical target volume (CTV)...
January 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28155608/helical-tomotherapy-versus-conventional-technique-for-post-mastectomy-left-sided-breast-cancer-dosimetric-study
#12
M O Alshabanah, Mohamed Hegazy, Belal Moftah, Mohammad Shabanah
METHODS AND MATERIALS: Treatment plans were generated for 5 post mastectomy left sided breast cancer patients treated at king Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia, comparing three-dimensional technique with the HT planning. The prescribed dose was 50 Gy in 25 fractions; the planning target volume (chest wall and nodal volumes) was contoured according to RTOG atlas and the heart, lungs, spinal cord and contralateral breast were contoured as Organs at Risks (OARs)...
February 1, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28143487/helical-tomotherapy-of-spinal-chordomas-french-multicentric-retrospective-study-of-a-cohort-of-30-cases
#13
Maxime Bobin, Christina Zacharatou, Paul Sargos, Véronique Brouste, Albert Lisbona, Marc-André Mahé, Georges Noël, Amandine Halley, Loïc Feuvret, Louis Gras, Stéphanie Hoppe, Bénédicte Henriques de Figueiredo, Guy Kantor
PURPOSE: To evaluate the efficacy and toxicity of helical tomotherapy (HT) in the management of spine chordomas when proton therapy is unavailable or non-feasible. METHODS AND MATERIALS: Between 2007 and 2013, 30 patients with biopsy-proven chordomas were treated by HT in five French institutions. Information regarding local control (LC), overall survival (OS), progression-free survival (PFS) and metastasis-free survival (MFS) was collected. Clinical efficacy, toxicity and treatment quality were evaluated...
January 31, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28129971/dosimetric-aspects-of-breast-radiotherapy-with-three-dimensional-and-intensity-modulated-radiotherapy-helical-tomotherapy-planning-modules
#14
Poonam Yadav, Yue Yan, Tasha Ignatowski, Anna Olson
In this work, we investigated the dosimetric differences between the intensity-modulated radiotherapy (IMRT) plans and the three-dimensional (3D) helical plans based on the TomoTherapy system. A total of 15 patients with supine setup were randomly selected from the data base. For patients with lumpectomy planning target volume (PTV), regional lymph nodes were also included as part of the target. For dose sparing, the significant differences between the helical IMRT and helical 3D were only found in the heart and contralateral breast...
April 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28129767/helical-tomotherapy-for-locally-advanced-or-recurrent-breast-cancer
#15
M N Duma, C Heinrich, C Schönknecht, B Chizzali, M Mayinger, M Devecka, S Kampfer, S E Combs
PURPOSE: We report our experience of using helical tomotherapy (HT) to treat large and irregular shaped loco-regional advanced breast cancer target volumes embracing various organs at risk. PATIENTS AND METHODS: We retrospectively analyzed 26 patients treated for very large, irregular shaped breast cancers. Patients were treated either with the intent to achieve local control in a primary setting (n = 14) or in a reirradiation setting (n = 12). The recurrence group was heavily pretreated with systemic therapy...
January 28, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28126476/optimization-of-brain-metastases-radiotherapy-with-tomohda
#16
Slav Yartsev, Glenn Bauman
An upgrade of the helical tomotherapy technology by introducing variable fan-field width (dynamic jaws) reduced the penumbra in superior-inferior direction for the target. Possible implementation of this upgrade even for the cases of the targets with different dose prescriptions is proposed. An example of brain metastasis in proximity to the optical apparatus in need of the whole brain irradiation of 30 Gy and higher dose to the lesion is considered.
April 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28126475/clinical-benefits-of-new-immobilization-system-for-hypofractionated-radiotherapy-of-intrahepatic-hepatocellular-carcinoma-by-helical-tomotherapy
#17
Yong Hu, Yong-Kang Zhou, Yi-Xing Chen, Shi-Ming Shi, Zhao-Chong Zeng
OBJECTIVE: A comprehensive clinical evaluation was conducted, assessing the Body Pro-Lok immobilization and positioning system to facilitate hypofractionated radiotherapy of intrahepatic hepatocellular carcinoma (HCC), using helical tomotherapy to improve treatment precision. METHODS: Clinical applications of the Body Pro-Lok system were investigated (as above) in terms of interfractional and intrafractional setup errors and compressive abdominal breath control...
April 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28110824/clinical-significance-of-treatment-delivery-errors-for-helical-tomotherapy-nasopharyngeal-plans-a-dosimetric-simulation-study
#18
Shrikant Deshpande, Mark Geurts, Philip Vial, Peter Metcalfe, Mark Lee, Lois Holloway
PURPOSE: Develop a framework to characterize helical TomoTherapy (HT) machine delivery errors and their clinical significance. METHOD AND MATERIALS: Ten nasopharynx HT plans were edited to introduce errors in Jaw width (JW), couch speed (CS), gantry period (GP), gantry start position (GSP), multi leaf collimator leaf open times (MLC LOT). In case of MLC LOT only, both systematic and random delivery errors were investigated. Each error type was simulated independently for a range of magnitudes...
January 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28096196/craniospinal-irradiation-using-helical-tomotherapy-for-central-nervous-system-tumors
#19
Sanziana R I Schiopu, Gregor Habl, Matthias Häfner, Sonja Katayama, Klaus Herfarth, Juergen Debus, Florian Sterzing
The aim of this study was to describe early and late toxicity, survival and local control in 45 patients with primary brain tumors treated with helical tomotherapy craniospinal irradiation (HT-CSI). From 2006 to 2014, 45 patients with central nervous system malignancies were treated with HT-CSI. The most common tumors were medulloblastoma in 20 patients, ependymoma in 10 patients, intracranial germinoma (ICG) in 7 patients, and primitive neuroectodermal tumor in 4 patients. Hematological toxicity during treatment included leukopenia Grades 1-4 (6...
January 17, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28089479/estimation-of-radiation-induced-secondary-cancer-risks-for-early-stage-non-small-cell-lung-cancer-patients-after-stereotactic-body-radiation-therapy
#20
Chunhui Han, Timothy E Schultheiss, Jeffrey Y C Wong
PURPOSE: In this study, we evaluated radiation-induced secondary lung cancer risks for the lung and the breast from stereotactic body radiation therapy treatment of early-stage non-small cell lung cancer with different radiation therapy treatment modalities. METHODS AND MATERIALS: Ten patients (5 men and 5 women) with early-stage non-small cell lung cancer who received definitive stereotactic body radiation therapy treatments were retrospectively selected. For each patient, two 3-dimensional conformal radiation therapy (3D-CRT) plans using 6- and 10-MV photons, respectively; a helical tomotherapy (HT) plan; and 2 volumetric modulated arc therapy (VMAT) plans using 1 and 2 arcs, respectively, were generated...
October 19, 2016: Practical Radiation Oncology
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