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https://www.readbyqxmd.com/read/28329888/osteo-odonto-keratoprosthesis-in-severe-ocular-graft-versus-host-disease
#1
K Plattner, D Goldblum, J Halter, C Kunz, R Koeppl, N Gerber-Hollbach
No abstract text is available yet for this article.
March 22, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28282315/current-approaches-to-treatment-of-ocular-graft-versus-host-disease
#2
Cynthia I Tung
No abstract text is available yet for this article.
2017: International Ophthalmology Clinics
https://www.readbyqxmd.com/read/28267083/toxic-epidermal-necrolysis-like-reaction-after-hematopoietic-stem-cell-transplantation-in-children
#3
Maura Faraci, Stefano Giardino, Edoardo Lanino, Giuseppe Morreale, Emilia Ghibaudo, Monica Francesia Berta, Marco Risso, Elio Castagnola, Mimmo Ripaldi, Andrea Moscatelli, Giovanni Ghigliotti
This study report clinical course, etiology, management, and long-term outcome of children who developed toxic epidermal necrolysis-like reaction (TEN-LR) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). We retrospectively collected children with TEN-LR occurring after allo-HSCT performed in 2 pediatric bone marrow units between 2005 and 2014. We identified 6 cases of TEN-LR of 322 patients (1.8%). Possible triggers of TEN included antibiotics, antiepileptics, antimycotics, and Mycoplasma infection...
March 6, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28218751/scleral-lenses-for-severe-chronic-gvhd-related-keratoconjunctivitis-sicca-a-retrospective-study-by-the-sfgm-tc
#4
L Magro, J Gauthier, M Richet, M Robin, S Nguyen, F Suarez, J-H Dalle, T Fagot, A Huynh, M-T Rubio, R Oumadely, S Vigouroux, N Milpied, A Delcampe, I Yakoub-Agha
Chronic GvHD-related keratoconjunctivitis sicca (cGvHD-related KCS) can significantly alter the quality of life of patients after allogeneic hematopoietic stem cell transplantation. The aim of this work was to assess the efficacy and tolerability of scleral lenses to treat severe cGvHD-related KCS. In this retrospective, multicenter study, we included 60 consecutive patients diagnosed with cGvHD-related KCS and fitted with scleral lenses. Patients were evaluated at baseline and at 2 months with the following tests: the Ocular Surface Disease Index (OSDI) to assess quality of life, the Oxford score to grade corneal damage and the logarithm of minimal angle of resolution (Log MAR) scale to determine visual acuity...
February 20, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28165063/heavy-chain-hyaluronan-pentraxin-3-from-amniotic-membrane-suppresses-inflammation-and-scarring-in-murine-lacrimal-gland-and-conjunctiva-of-chronic-graft-versus-host-disease
#5
Yoko Ogawa, Hua He, Shin Mukai, Toshihiro Imada, Shigeru Nakamura, Chen-Wei Su, Megha Mahabole, Scheffer C G Tseng, Kazuo Tsubota
Chronic graft-versus-host disease (cGVHD) is a major complication of hematopoietic stem cell transplantation. Dry eye disease is the prominent ocular sequel of cGVHD and is caused by excessive inflammation and fibrosis in the lacrimal glands. Heavy chain-Hyaluronan/Pentraxin 3 (HC-HA/PTX3) is a complex purified from human amniotic membrane (AM) and known to exert anti-inflammatory and anti-scarring actions. In this study, we utilized a mouse model of cGVHD to examine whether HC-HA/PTX3 could attenuate dry eye disease elicited by cGVHD...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28109687/-ocular-graft-versus-host-disease-an-often-misdiagnosed-etiology-of-dry-eye-syndrome
#6
L Moyal, R Adam, J Akesbi, F T Rodallec, J-P Nordmann
PURPOSE: To report a case of severe ocular graft-versus-host disease (GVHD) after cataract surgery. METHODS: Observational case report. RESULTS: We describe the case of a 59-year-old man with postoperative corneal ulcer on his only functional eye. His past history reported allogenic bone marrow transplant. His visual acuity (VA) was limited to hand motions. Slit lamp examination revealed diffuse conjunctival hyperemia, severe blepharitis, Meibomian dysfunction, total corneal opacification with epithelial and stromal keratitis and neovascular invasion...
February 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28089075/conjunctival-impression-cytology-evaluation-of-patients-with-dry-eye-disease-using-scleral-contact-lenses
#7
Sarah La Porta Weber, Rossen Mihaylov Hazarbassanov, Alex Nasaré, José Álvaro Pereira Gomes, Ana Luisa Hofling-Lima
PURPOSE: To evaluate conjunctival impression cytology and HLADR expression changes after wearing scleral contact lenses (ScCLs) for moderate to severe dry eye disease (DED). DESIGN: Prospective interventional case series. METHODS: Forty-one eyes from 25 patients with moderate to severe DED were evaluated for Esclera ScCL treatment. Best-corrected visual acuity (BCVA) and slit-lamp findings were assessed. Impression cytology specimens were obtained from DED patients at the baseline and after wearing ScCLs for 12 months...
January 6, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28073648/elevated-neutrophil-elastase-in-tears-of-ocular-graft-versus-host-disease-patients
#8
Samer N Arafat, Marie-Claude Robert, Tulio Abud, Sandra Spurr-Michaud, Francisco Amparo, Claes H Dohlman, Reza Dana, Ilene K Gipson
PURPOSE: To investigate the levels of neutrophil elastase (NE), matrix metalloproteinases (MMPs) and myeloperoxidase (MPO) in tear washes of patients with ocular graft-versus-host disease (oGVHD). DESIGN: Case-control study. METHODS: Based on established criteria, oGVHD patients (n = 14; 28 eyes) and age/sex-matched healthy controls (n = 14; 28 eyes) were enrolled. Tear washes were collected and analyzed for NE using a single-analyte enzyme-linked immunosorbent assay (ELISA)...
January 7, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28060078/validation-of-international-chronic-ocular-graft-versus-host-disease-gvhd-group-diagnostic-criteria-as-a-chronic-ocular-gvhd-specific-metric
#9
Yuna Rapoport, Thomas Freeman, Tatsuki Koyama, Brian G Engelhardt, Madan Jagasia, Bipin N Savani, Uyen Tran, Adetola A Kassim
PURPOSE: To validate the International Chronic Ocular GVHD Consensus Group (ICCGVHD) diagnostic criteria for chronic ocular chronic graft-versus-host disease (GVHD), by comparing results with comprehensive ophthalmic evaluation after allogeneic hematopoietic stem cell transplantation. METHODS: A single-institution retrospective chart review was conducted on patients who underwent hematopoietic stem cell transplantation at Vanderbilt University Medical Center in Nashville, TN, from January 1, 2002, through April 17, 2014...
February 2017: Cornea
https://www.readbyqxmd.com/read/28024826/predictors-of-discordance-between-symptoms-and-signs-in-dry-eye-disease
#10
Jelle Vehof, Nicole Sillevis Smitt-Kamminga, Simone A Nibourg, Christopher J Hammond
PURPOSE: To investigate predictors of discordance between symptoms and signs in dry eye disease (DED). DESIGN: Cross-sectional association study. PARTICIPANTS: A total of 648 patients with dry eye from the Groningen LOngitudinal Sicca StudY (GLOSSY), a tertiary dry eye clinic patient cohort from the Netherlands. METHODS: Patient symptoms were assessed using the Ocular Surface Disease Index (OSDI) questionnaire. Dry eye signs were assessed by tear osmolarity, Schirmer test, tear breakup time, corneal and conjunctival staining, and meibomian gland dysfunction, all in both eyes, and a composite dry eye signs severity score was calculated from these 6 tests for each patient...
March 2017: Ophthalmology
https://www.readbyqxmd.com/read/28013013/a-canine-model-of-chronic-graft-versus-host-disease
#11
Scott S Graves, Andrew Rezvani, George Sale, Diane Stone, Maura Parker, Steven Rosinski, Michele Spector, Bruce Swearingen, Leslie Kean, Rainer Storb
In long-term survivors of allogeneic hematopoietic cell transplantation (HCT), chronic graft-versus-host disease (GVHD) is the major cause of morbidity and mortality and a major determinant of quality of life. Chronic GVHD responds poorly to current immunosuppressive drugs, and while T cell depletion may be preventive, this gain is offset by increased relapse rates. A significant impediment to progress in treating chronic GVHD has been the limitations of existing animal models. The goal of this study was to develop a reproducible comprehensive model of chronic GVHD in the dog...
March 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27984363/validation-of-international-chronic-ocular-graft-versus-host-disease-gvhd-group-diagnostic-criteria-as-a-chronic-ocular-gvhd-specific-metric
#12
Yuna Rapoport, Thomas Freeman, Tatsuki Koyama, Brian G Engelhardt, Madan Jagasia, Bipin N Savani, Uyen Tran, Adetola A Kassim
PURPOSE: To validate the International Chronic Ocular GVHD Consensus Group (ICCGVHD) diagnostic criteria for chronic ocular chronic graft-versus-host disease (GVHD), by comparing results with comprehensive ophthalmic evaluation after allogeneic hematopoietic stem cell transplantation. METHODS: A single-institution retrospective chart review was conducted on patients who underwent hematopoietic stem cell transplantation at Vanderbilt University Medical Center in Nashville, TN, from January 1, 2002, through April 17, 2014...
December 14, 2016: Cornea
https://www.readbyqxmd.com/read/27902756/conjunctival-acute-graft-versus-host-disease-in-adult-patients-receiving-allogeneic-hematopoietic-stem-cell-transplantation-a-cohort-study
#13
Yao-Chung Liu, Jyh-Pyng Gau, Pei-Yu Lin, Catherine Jui-Ling Liu, Chia-Jen Liu, Jin-Hwang Liu, Nai-Wen Fan
BACKGROUND: To investigate the incidence, risk factors and survival of conjunctival acute graft-versus-host disease (aGVHD) in adult patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). METHODS: This retrospective study included a total of 139 patients undergoing allogeneic HSCT between January 2012 and December 2014 at a tertiary referral hospital. Patients with ocular complaints after allogeneic HSCT or first donor lymphocyte infusion were evaluated by ophthalmologists...
2016: PloS One
https://www.readbyqxmd.com/read/27834728/graft-versus-self-gvs-against-t-cell-autoantigens-is-a-mechanism-of-graft-host-interaction
#14
Nora Mirza, Manfred Zierhut, Andreas Korn, Antje Bornemann, Wichard Vogel, Barbara Schmid-Horch, Wolfgang A Bethge, Stefan Stevanović, Helmut R Salih, Lothar Kanz, Hans-Georg Rammensee, Sebastian P Haen
Graft-versus-host disease (GVHD) represents the major nonrelapse complication of allogeneic hematopoietic cell transplantation. Although rare, the CNS and the eye can be affected. In this study, manifestation in the retina as part of the CNS and T-cell epitopes recognized by the allogeneic T cells were evaluated. In 2 of 6 patients with posttransplantation retina diseases and 6 of 22 patients without ocular symptoms, antigen-specific T-cell responses against retina-specific epitopes were observed. No genetic differences between donor and recipient could be identified indicating T-cell activation against self-antigens (graft versus self)...
November 29, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27741087/prose-treatment-in-atypical-ocular-graft-versus-host-disease
#15
Gloria B Chiu, Christos Theophanous, John A Irvine
PURPOSE: To report a case of persistent epithelial defects in a patient with ocular chronic graft-versus-host disease that required coordinated modulation of systemic immunosuppressive treatment and overnight wear of Prosthetic Replacement of the Ocular Surface Ecosystem (BostonSight PROSE, Needham, MA) devices to achieve ocular surface healing. CASE REPORT: The case of a 38-year-old male patient who presented with a 2-year history of ocular chronic graft-versus-host disease, ocular burning, pain, light sensitivity, and a 3-week history of bilateral corneal epithelial defects is presented...
November 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/27595285/long-term-safety-and-efficacy-of-autologous-platelet-lysate-drops-for-treatment-of-ocular-gvhd
#16
S Pezzotta, C Del Fante, L Scudeller, G C Rossi, C Perotti, P E Bianchi, E Antoniazzi
Current ocular GvHD (oGvHD) treatments are suboptimal. We investigated the safety and efficacy of long-term continuous treatment with autologous platelet lysate (PL) drops in patients with oGvHD Dry Eye Syndrome (DES) score 2-3 refractory to topical conventional therapy. Ophthalmic evaluation was performed at 6 month intervals. Symptoms were assessed using the Glaucoma Symptom Scale (GSS). Patients were defined 'responders' when showing a reduction at least one grade on National Institutes of Health Eye Score from baseline at the 6 month visit...
January 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/27567559/prgf-exerts-more-potent-proliferative-and-anti-inflammatory-effects-than-autologous-serum-on-a-cell-culture-inflammatory-model
#17
E Anitua, F Muruzabal, M de la Fuente, A Riestra, J Merayo-Lloves, G Orive
Ocular graft versus host disease (oGVHD) is part of a systemic inflammatory disease that usually affects ocular surface tissues manifesting as a dry eye syndrome. Current treatments provide unsatisfactory results. Blood-derived products, like plasma rich in growth factors (PRGF) emerge as a potential therapy for this disease. The purpose of this study was to evaluate the tissue regeneration and anti-inflammatory capability of PRGF, an autologous platelet enriched plasma eye-drop, compared to autologous serum (AS) obtained from oGVHD patients on ocular surface cells cultured in a pro-inflammatory environment...
October 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27492793/novel-scoring-criteria-for-the-evaluation-of-ocular-graft-versus-host-disease-in-a-preclinical-allogeneic-hematopoietic-stem-cell-transplantation-animal-model
#18
Victor L Perez, Alexander Barsam, Stephanie Duffort, Maitee Urbieta, Henry Barreras, Casey Lightbourn, Krishna V Komanduri, Robert B Levy
Ocular complications occur after transplantation in 60% to 90% of chronic graft-versus-host disease (GVHD) patients and significantly impair vision-related quality of life. Ocular surface inflammation and dry eye disease are the most common manifestations of ocular GVHD. Ocular GVHD can be viewed as an excellent preclinical model that can be studied to understand the immune pathogenesis of this common and debilitating disease. A limitation of this is that only a few experimental models mimic the ocular complications after hematopoietic stem cell transplantation (HSCT) and have focused on the acute GVHD process...
October 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27380960/safety-and-efficacy-of-autologous-serum-eye-drop-for-treatment-of-dry-eyes-in-graft-versus-host-disease
#19
Amir A Azari, Remzi Karadag, Mozhgan Rezaei Kanavi, Sarah Nehls, Neal Barney, Kyungmann Kim, Walter Longo, Peiman Hematti, Mark Juckett
PURPOSE: To evaluate the treatment of autologous serum eye drops (ASED) on dry eyes in patients with graft-versus-host disease (GVHD). METHODS: A retrospective chart review of 35 patients with a history of ocular GVHD following hematopoietic stem cell transplantation that used ASED to alleviate dry eye symptoms was performed. Patients were categorized into three different groups. If patients had available ophthalmic data before and after starting treatment was group 1 (n = 14), had available ophthalmic data after starting treatment in group 2 (n = 10) and had available ophthalmic data before treatment or did not have any data after starting treatment in group 3 (n = 11)...
July 22, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27373389/cataract-surgery-in-patients-with-chronic-severe-graft-versus-host-disease
#20
Ankit Shah, Marcony R Santhiago, Edgar M Espana
PURPOSE: To evaluate the surgical outcomes of cataract extraction with phacoemulsification and intraocular lens implantation in patients with severe chronic ocular graft-versus-host disease (GVHD). SETTING: University of South Florida Eye Institute, Tampa, Florida, USA. DESIGN: Retrospective case study. METHODS: A chart review was performed to identify patients with clinically severe, biopsy-proven chronic ocular GVHD who had cataract extraction...
June 2016: Journal of Cataract and Refractive Surgery
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