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Ferumoxytol

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https://www.readbyqxmd.com/read/29764855/magnetic-resonance-imaging-of-tumor-associated-macrophages-clinical-translation
#1
Maryam Aghighi, Ashok Joseph Theruvath, Anuj Pareek, Laura Pisani, Raphael Alford, Anne Monika Muehe, Tarsheen K Sethi, Samantha J Holdsworth, Florette K Hazard, Dita Gratzinger, Sandra Luna-Fineman, Ranjana H Advani, Sheri L Spunt, Heike E Daldrup-Link
PURPOSE: Tumor associated macrophages (TAM) in malignant tumors have been linked to tumor aggressiveness and represent a new target for cancer immunotherapy. As new TAM-targeted immunotherapies are entering clinical trials, it is important to detect and quantify TAM with non-invasive imaging techniques. The purpose of this study was to determine if ferumoxytol-enhanced MRI can detect TAM in lymphomas and bone sarcomas of pediatric patients and young adults. EXPERIMENTAL DESIGN: In a first-in-patient , IRB-approved prospective clinical trial, 25 pediatric and young adult patients with lymphoma or bone sarcoma underwent ferumoxytol-enhanced MRI...
May 15, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29762436/preoperative-analysis-of-venous-anatomy-before-deep-inferior-epigastric-perforator-free-flap-breast-reconstruction-using-ferumoxytol-enhanced-magnetic-resonance-angiography
#2
John Dortch, Antonio J Forte, Candice Bolan, Pujan Kandel, Galen Perdikis
BACKGROUND: Venous congestion after deep inferior epigastric artery perforator (DIEP) flap breast reconstruction is a complication that may be partially attributable to variations in venous abdominal wall anatomy. In previous work, we have shown that ferumoxytol may be used as a bloodpool contrast agent to perform high-resolution venous imaging. Our current aim was to use this technology to perform a detailed analysis of the venous anatomy among patients undergoing DIEP flap breast reconstruction...
May 14, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29731126/ferumoxytol-enhanced-mri-in-the-peripheral-vasculature
#3
REVIEW
E D Lehrman, A N Plotnik, T Hope, D Saloner
Ferumoxytol is a promising non-gadolinium-based contrast agent with numerous varied magnetic resonance imaging applications. Previous reviews of vascular applications have focused primarily on cardiac and aortic applications. After considering safety concerns and technical issues, the objective of this paper is to explore peripheral applications for ferumoxytol-enhanced magnetic resonance angiography (MRA) and venography (MRV) in the upper and lower extremities. Separate searches for each of the following keywords were performed in pubmed: "ferumoxytol," "ultrasmall superparamagnetic iron oxide," and "USPIO...
May 3, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29700591/the-role-of-mr-imaging-in-the-assessment-of-renal-allograft-vasculature
#4
REVIEW
Raj Gondalia, Federica Vernuccio, Daniele Marin, Mustafa R Bashir
Renal allograft dysfunction after transplantation is a relatively common occurrence with various potential etiologies. Vascular etiologies are of particular importance as early surgical or minimally invasive intervention can, in some cases, salvage the graft. Diagnosis of vascular pathology resulting in allograft dysfunction requires a thorough workup, of which imaging is a key component. Generally, ultrasound is the first-line imaging modality. More recently, MRI has been shown to be an effective and safe modality for diagnosis of vascular pathology after renal transplantation, particularly for diagnosis of transplant renal artery stenosis...
April 26, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29699506/correction-to-the-ferumoxytol-for-anemia-of-ckd-trial-fact-a-randomized-controlled-trial-of-repeated-doses-of-ferumoxytol-or-iron-sucrose-in-patients-on-hemodialysis-background-and-rationale
#5
Iain C Macdougall, Naomi V Dahl, Kristine Bernard, Zhu Li, Alka Batycky, William E Strauss
Following publication of the original article [1], the authors reported that one of the authors' name is spelled incorrectly. In this Erratum the incorrect and correct author name are shown. The original publication of this article has been corrected.
April 26, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29669068/adverse-reactions-after-intravenous-iron-infusion-among-inflammatory-bowel-disease-patients-in-the-united-states-2010-2014
#6
Eboselume Akhuemonkhan, Alyssa Parian, Kathryn A Carson, Susan Hutfless
Background: Anemia is a frequent complication of Crohn's disease (CD) and ulcerative colitis (UC), collectively known as inflammatory bowel disease (IBD). Intravenous (IV) iron is recommended as the initial therapy for patients with clinically active IBD, severe anemia, and intolerance to oral iron. IV iron is associated with serious adverse effects including a black box warning for anaphylaxis with iron dextran and ferumoxytol. We aimed to examine the occurrence of adverse reactions including anaphylaxis after IV iron infusions in a large database of US IBD patients...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29644371/ferumoxytol-of-ultrahigh-magnetization-produced-by-hydrocooling-and-magnetically-internal-heating-co-precipitation
#7
Bo Chen, Jianfei Sun, Fengguo Fan, Xiangzhi Zhang, Zhiguo Qin, Peng Wang, Yang Li, Xiquan Zhang, Fei Liu, Yanlong Liu, Min Ji, Ning Gu
Ferumoxytol, which is originally intended for MRI and anemia treatment, is currently the only inorganic nanodrug approved by FDA for clinical application in vivo. Common ferumoxytol seems incapable of meeting the requirements for diverse applications. Thus, the development of a novel strategy based on co-precipitation to produce ferumoxytol with high quality is an imminent task. Herein, we proposed a physically assisted strategy, namely hydrocooling and magnetically internal heating co-precipitation, to optimize the properties of ferumoxytol and thus significantly enhance its magnetic performance...
April 12, 2018: Nanoscale
https://www.readbyqxmd.com/read/29417614/comparative-safety-of-intravenous-ferumoxytol-versus-ferric-carboxymaltose-in-iron-deficiency-anemia-a-randomized-trial
#8
N Franklin Adkinson, William E Strauss, Iain C Macdougall, Kristine E Bernard, Michael Auerbach, Robert F Kaper, Glenn M Chertow, Julie S Krop
Few trials have examined rates of hypersensitivity reactions (HSRs) with intravenous iron formulations used to treat iron deficiency anemia (IDA). This randomized, multicenter, double-blind clinical trial compared the safety, and efficacy of ferumoxytol versus ferric carboxymaltose (FCM), focusing on rates of HSRs and hypotension as the primary end point. Patients with IDA of any etiology in whom oral iron was unsatisfactory or intolerable received ferumoxytol (n = 997) or FCM (n = 1000) intravenously over ≥15 minutes on days 1 and 8 or 9 for total respective doses of 1...
May 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29392488/novel-contrast-mixture-achieves-contrast-resolution-of-human-bladder-wall-suitable-for-t1-mapping-applications-in-interstitial-cystitis-and-beyond
#9
Pradeep Tyagi, Joseph Janicki, Chan-Hong Moon, Jonathan Kaufman, Christopher Chermansky
PURPOSE: Instillation of novel contrast mixture (NCM) was recently shown to improve the contrast resolution of rat bladder wall with high contrast-to-noise ratio (CNR). Here, the clinical safety and the feasibility of NCM-enhanced MRI to achieve artifact-free visualization of human bladder wall suitable for quantitative measurement of the magnetic resonance (MR) longitudinal relaxation time (T1) was assessed. METHODS: Six female subjects [two controls and two with Hunner-type interstitial cystitis IC and two with non-Hunner-type IC] consented for MRI at 3 T before and after instillation of NCM [4 mM gadobutrol and 5 mM ferumoxytol in 50 mL of sterile water for injection]...
March 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29366154/femoral-plaque-imaging-using-ferumoxytol-nanoparticles-and-dynamic-contrast-enhanced-mri-in-patients-with-peripheral-artery-disease
#10
Kang He Zheng, Jasper Schoormans, Lotte Stiekema, Erik Stroes, Gustav Strijkers, Aart Nederveen, Bram Coolen
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29360591/current-perspectives-in-imaging-modalities-for-the-assessment-of-unruptured-intracranial-aneurysms-a-comparative-analysis-and-review
#11
REVIEW
Nefize Turan, Robert A Heider, Anil K Roy, Brandon A Miller, Mark E Mullins, Daniel L Barrow, Jonathan Grossberg, Gustavo Pradilla
BACKGROUND: Intracranial aneurysms (IA) are pathological dilatations of cerebral arteries. This systematic review summarizes and compares imaging techniques for assessing unruptured intracranial aneurysms (UIAs). This review also addresses their uses in different scopes of practice. Pathophysiologic mechanisms are reviewed to better understand the clinical utility of each imaging modality. METHODS: A literature review was performed using PubMed with these search terms: "intracranial aneurysm," "cerebral aneurysm," "magnetic resonance angiography (MRA)," computed tomography angiography (CTA)," "catheter angiography," "digital subtraction angiography," "molecular imaging" "ferumoxytol" and "myeloperoxidase"...
January 19, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29354012/-in-vivo-visualization-of-iron-oxide-enhancement-in-focal-pulmonary-inflammatory-lesions-using-a-three-dimensional-radial-gradient-echo-based-ultrashort-echo-time-sequence-a-preliminary-study
#12
Soon Ho Yoon, Chanhee Lee, Jinil Park, Jin Mo Goo, Jang-Yeon Park
Objective: To preliminarily evaluate technical feasibility of a dual-echo ultrashort echo time (UTE) subtraction MR imaging by using concurrent dephasing and excitation (CODE) sequence for visualization of iron-oxide enhancement in focal inflammatory pulmonary lesions. Materials and Methods: A UTE pulmonary MR imaging before and after the injection of clinically usable superparamagnetic iron-oxide nanoparticles, ferumoxytol, was conducted using CODE sequence with dual echo times of 0...
January 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/29314418/cerebral-blood-volume-mapping-with-ferumoxytol-in-dynamic-susceptibility-contrast-perfusion-mri-comparison-to-standard-of-care
#13
Csanad G Varallyay, Eric Nesbit, Andrea Horvath, Peter Varallyay, Rongwei Fu, Seymur Gahramanov, Leslie L Muldoon, Xin Li, William D Rooney, Edward A Neuwelt
BACKGROUND: Cerebral blood volume (CBV) mapping with a dynamic susceptibility contrast (DSC) perfusion technique has become a clinical tool in diagnosing and follow-up of brain tumors. Ferumoxytol, a long-circulating iron oxide nanoparticle, has been tested for CBV mapping, but the optimal dose has not been established. PURPOSE: To compare ferumoxytol DSC of two different doses to standard of care gadoteridol by analyzing time-intensity curves and CBV maps in normal-appearing brain regions...
January 4, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29284494/ferumoxytol-enhanced-black-blood-cardiovascular-magnetic-resonance-imaging
#14
Kim-Lien Nguyen, Eun-Ah Park, Takegawa Yoshida, Peng Hu, J Paul Finn
BACKGROUND: Bright-blood and black-blood cardiovascular magnetic resonance (CMR) techniques are frequently employed together during a clinical exam because of their complementary features. While valuable, existing black-blood CMR approaches are flow dependent and prone to failure. We aim to assess the effectiveness and reliability of ferumoxytol enhanced (FE) Half-Fourier Single-shot Turbo Spin-echo (HASTE) imaging without magnetization preparation pulses to yield uniform intra-luminal blood signal suppression by comparing FE-HASTE with pre-ferumoxytol HASTE imaging...
December 28, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29248659/intraluminal-assessment-of-coronary-arteries-with-ferumoxytol-enhanced-magnetic-resonance-angiography
#15
Matthew S Chin, Michael Steigner, Wenqing Yin, Raymond Y Kwong, Andrew M Siedlecki
No abstract text is available yet for this article.
March 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29215401/relaxivity-of-ferumoxytol-at-1-5-t-and-3-0-t
#16
Gesine Knobloch, Timothy Colgan, Curtis N Wiens, Xiaoke Wang, Tilman Schubert, Diego Hernando, Samir D Sharma, Scott Reeder
OBJECTIVES: The aim of this study was to determine the relaxation properties of ferumoxytol, an off-label alternative to gadolinium-based contrast agents, under physiological conditions at 1.5 T and 3.0 T. MATERIALS AND METHODS: Ferumoxytol was diluted in gradually increasing concentrations (0.26-4.2 mM) in saline, human plasma, and human whole blood. Magnetic resonance relaxometry was performed at 37°C at 1.5 T and 3.0 T. Longitudinal and transverse relaxation rate constants (R1, R2, R2*) were measured as a function of ferumoxytol concentration, and relaxivities (r1, r2, r2*) were calculated...
December 5, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/29205477/quantitative-comparison-of-delayed-ferumoxytol-t-1-enhancement-with-immediate-gadoteridol-enhancement-in-high-grade-gliomas
#17
Andrea Horváth, Csanad G Varallyay, Daniel Schwartz, Gerda B Toth, Joao P Netto, Ramon Barajas, Péter Várallyay, László Szidonya, Jenny Firkins, Emily Youngers, Rongwei Fu, Prakash Ambady, Péter Bogner, Edward A Neuwelt
PURPOSE: Delayed ferumoxytol enhancement on T1 -weighted images appears visually similar to gadoteridol enhancement. The purpose of this study was to quantitatively compare ferumoxytol T1 enhancement to gadoteridol enhancement with an objective, semi-automated method. METHODS: 206 sets of post-gadoteridol and 24 h post-ferumoxytol T1 -weighted scans from 58 high grade glioma patients were analyzed (9 pre-chemoradiation, 111 < 90 days post-chemoradiation, 21 > 90 days post-chemoradiation, 65 post-bevacizumab scans)...
December 4, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29177411/ultrasmall-superparamagnetic-iron-oxide-imaging-identifies-tissue-and-nerve-inflammation-in-pain-conditions
#18
Shiqian Shen, Weihua Ding, Shihab Ahmed, Ranliang Hu, Arissa Opalacz, Sarah Roth, Zerong You, Gregory R Wotjkiewicz, Grewo Lim, Lucy Chen, Jianren Mao, John W Chen, Yi Zhang
Objective: Correlation between radiologic structural abnormalities and clinical symptoms in low back pain patients is poor. There is an unmet clinical need to image inflammation in pain conditions to aid diagnosis and guide treatment. Ferumoxytol, an ultrasmall superparamagnetic iron oxide (USPIO) nanoparticle, is clinically used to treat iron deficiency anemia and showed promise in imaging tissue inflammation in human. We explored whether ferumoxytol can be used to identify tissue and nerve inflammation in pain conditions in animals and humans...
April 1, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29140566/mesenchymal-stem-cell-preparation-and-transfection-free-ferumoxytol-labeling-for-mri-cell-tracking
#19
Li Liu, Chien Ho
Mesenchymal stem cells (MSCs) are multipotent cells and are the most widely studied cell type for stem cell therapies. In vivo cell tracking of MSCs labeled with an FDA-approved superparamagnetic iron-oxide (SPIO) particle by magnetic resonance imaging (MRI) provides essential information, e.g., MSC engraftment, survival, and fate, thus improving cell therapy accuracy. However, current methodology for labeling MSCs with Ferumoxytol (Feraheme® ), the only FDA-approved SPIO particle, needs transfection agents...
November 15, 2017: Current Protocols in Stem Cell Biology
https://www.readbyqxmd.com/read/29111494/macrophages-as-a-potential-tumor-microenvironment-target-for-noninvasive-imaging-of-early-response-to-anticancer-therapy
#20
Qizhen Cao, Xinrui Yan, Kai Chen, Qian Huang, Marites P Melancon, Gabriel Lopez, Zhen Cheng, Chun Li
As a result of therapy-induced apoptosis, peripheral blood monocytes are recruited to tumors, where they become tumor-associated macrophages (TAMs). To date, few studies have investigated noninvasive molecular imaging for assessment of macrophage infiltration in response to therapy-induced apoptosis. Here, noninvasive assessment of changes in tumor accumulation of TAMs was proposed as a new way to measure early tumor response to anticancer therapy. Three different nanoparticles, QD710-Dendron quantum dots (QD710-D), Ferumoxytol, and PG-Gd-NIR813, were used for near-infrared fluorescence imaging, T2-weighted magnetic resonance imaging, and dual optical/T1-weighted MR imaging, respectively, in the MDA-MB-435 tumor model...
January 2018: Biomaterials
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