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Ferumoxytol

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https://www.readbyqxmd.com/read/29314418/cerebral-blood-volume-mapping-with-ferumoxytol-in-dynamic-susceptibility-contrast-perfusion-mri-comparison-to-standard-of-care
#1
Csanad G Varallyay, Eric Nesbit, Andrea Horvath, Peter Varallyay, Rongwei Fu, Seymur Gahramanov, Leslie L Muldoon, Xin Li, William D Rooney, Edward A Neuwelt
BACKGROUND: Cerebral blood volume (CBV) mapping with a dynamic susceptibility contrast (DSC) perfusion technique has become a clinical tool in diagnosing and follow-up of brain tumors. Ferumoxytol, a long-circulating iron oxide nanoparticle, has been tested for CBV mapping, but the optimal dose has not been established. PURPOSE: To compare ferumoxytol DSC of two different doses to standard of care gadoteridol by analyzing time-intensity curves and CBV maps in normal-appearing brain regions...
January 4, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29284494/ferumoxytol-enhanced-black-blood-cardiovascular-magnetic-resonance-imaging
#2
Kim-Lien Nguyen, Eun-Ah Park, Takegawa Yoshida, Peng Hu, J Paul Finn
BACKGROUND: Bright-blood and black-blood cardiovascular magnetic resonance (CMR) techniques are frequently employed together during a clinical exam because of their complementary features. While valuable, existing black-blood CMR approaches are flow dependent and prone to failure. We aim to assess the effectiveness and reliability of ferumoxytol enhanced (FE) Half-Fourier Single-shot Turbo Spin-echo (HASTE) imaging without magnetization preparation pulses to yield uniform intra-luminal blood signal suppression by comparing FE-HASTE with pre-ferumoxytol HASTE imaging...
December 28, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29248659/intraluminal-assessment-of-coronary-arteries-with-ferumoxytol-enhanced-magnetic-resonance-angiography
#3
Matthew S Chin, Michael Steigner, Wenqing Yin, Raymond Y Kwong, Andrew M Siedlecki
No abstract text is available yet for this article.
December 8, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29215401/relaxivity-of-ferumoxytol-at-1-5-t-and-3-0-t
#4
Gesine Knobloch, Timothy Colgan, Curtis N Wiens, Xiaoke Wang, Tilman Schubert, Diego Hernando, Samir D Sharma, Scott Reeder
OBJECTIVES: The aim of this study was to determine the relaxation properties of ferumoxytol, an off-label alternative to gadolinium-based contrast agents, under physiological conditions at 1.5 T and 3.0 T. MATERIALS AND METHODS: Ferumoxytol was diluted in gradually increasing concentrations (0.26-4.2 mM) in saline, human plasma, and human whole blood. Magnetic resonance relaxometry was performed at 37°C at 1.5 T and 3.0 T. Longitudinal and transverse relaxation rate constants (R1, R2, R2*) were measured as a function of ferumoxytol concentration, and relaxivities (r1, r2, r2*) were calculated...
December 5, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/29205477/quantitative-comparison-of-delayed-ferumoxytol-t1-enhancement-with-immediate-gadoteridol-enhancement-in-high-grade-gliomas
#5
Andrea Horváth, Csanad G Varallyay, Daniel Schwartz, Gerda B Toth, Joao P Netto, Ramon Barajas, Péter Várallyay, László Szidonya, Jenny Firkins, Emily Youngers, Rongwei Fu, Prakash Ambady, Péter Bogner, Edward A Neuwelt
PURPOSE: Delayed ferumoxytol enhancement on T1 -weighted images appears visually similar to gadoteridol enhancement. The purpose of this study was to quantitatively compare ferumoxytol T1 enhancement to gadoteridol enhancement with an objective, semi-automated method. METHODS: 206 sets of post-gadoteridol and 24 h post-ferumoxytol T1 -weighted scans from 58 high grade glioma patients were analyzed (9 pre-chemoradiation, 111 < 90 days post-chemoradiation, 21 > 90 days post-chemoradiation, 65 post-bevacizumab scans)...
December 4, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29177411/ultrasmall-superparamagnetic-iron-oxide-imaging-identifies-tissue-and-nerve-inflammation-in-pain-conditions
#6
Shiqian Shen, Weihua Ding, Shihab Ahmed, Ranliang Hu, Arissa Opalacz, Sarah Roth, Zerong You, Gregory R Wotjkiewicz, Grewo Lim, Lucy Chen, Jianren Mao, John W Chen, Yi Zhang
Objective: Correlation between radiologic structural abnormalities and clinical symptoms in low back pain patients is poor. There is an unmet clinical need to image inflammation in pain conditions to aid diagnosis and guide treatment. Ferumoxytol, an ultrasmall superparamagnetic iron oxide (USPIO) nanoparticle, is clinically used to treat iron deficiency anemia and showed promise in imaging tissue inflammation in human. We explored whether ferumoxytol can be used to identify tissue and nerve inflammation in pain conditions in animals and humans...
November 21, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29140566/mesenchymal-stem-cell-preparation-and-transfection-free-ferumoxytol-labeling-for-mri-cell-tracking
#7
Li Liu, Chien Ho
Mesenchymal stem cells (MSCs) are multipotent cells and are the most widely studied cell type for stem cell therapies. In vivo cell tracking of MSCs labeled with an FDA-approved superparamagnetic iron-oxide (SPIO) particle by magnetic resonance imaging (MRI) provides essential information, e.g., MSC engraftment, survival, and fate, thus improving cell therapy accuracy. However, current methodology for labeling MSCs with Ferumoxytol (Feraheme(®) ), the only FDA-approved SPIO particle, needs transfection agents...
November 15, 2017: Current Protocols in Stem Cell Biology
https://www.readbyqxmd.com/read/29111494/macrophages-as-a-potential-tumor-microenvironment-target-for-noninvasive-imaging-of-early-response-to-anticancer-therapy
#8
Qizhen Cao, Xinrui Yan, Kai Chen, Qian Huang, Marites P Melancon, Gabriel Lopez, Zhen Cheng, Chun Li
As a result of therapy-induced apoptosis, peripheral blood monocytes are recruited to tumors, where they become tumor-associated macrophages (TAMs). To date, few studies have investigated noninvasive molecular imaging for assessment of macrophage infiltration in response to therapy-induced apoptosis. Here, noninvasive assessment of changes in tumor accumulation of TAMs was proposed as a new way to measure early tumor response to anticancer therapy. Three different nanoparticles, QD710-Dendron quantum dots (QD710-D), Ferumoxytol, and PG-Gd-NIR813, were used for near-infrared fluorescence imaging, T2-weighted magnetic resonance imaging, and dual optical/T1-weighted MR imaging, respectively, in the MDA-MB-435 tumor model...
January 2018: Biomaterials
https://www.readbyqxmd.com/read/29096054/comparison-of-ferumoxytol-based-cerebral-blood-volume-estimates-using-quantitative-r1-and-r2-relaxometry
#9
Leonardo A Rivera-Rivera, Tilman Schubert, Gesine Knobloch, Patrick A Turski, Oliver Wieben, Scott B Reeder, Kevin M Johnson
PURPOSE: Cerebral perfusion is commonly assessed clinically with dynamic susceptibility contrast MRI using a bolus injection of gadolinium-based contrast agents, resulting in semi-quantitative values of cerebral blood volume (CBV). Steady-state imaging with ferumoxytol allows estimation of CBV with the potential for higher precision and accuracy. Prior CBV studies have focused on the signal disrupting T2* effects, but ferumoxytol also has high signal-enhancing T1 relaxivity. The purpose of this study was to investigate and compare CBV estimation using T1 and T2*, with the goal of understanding the contrast mechanisms and quantitative differences...
November 2, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29091749/the-protein-corona-around-nanoparticles-facilitates-stem-cell-labeling-for-clinical-mr-imaging
#10
Hossein Nejadnik, Seyed-Meghdad Taghavi-Garmestani, Steven J Madsen, Kai Li, Saeid Zanganeh, Phillip Yang, Morteza Mahmoudi, Heike E Daldrup-Link
Purpose To evaluate if the formation of a protein corona around ferumoxytol nanoparticles can facilitate stem cell labeling for in vivo tracking with magnetic resonance (MR) imaging. Materials and Methods Ferumoxytol was incubated in media containing human serum (group 1), fetal bovine serum (group 2), StemPro medium (group 3), protamine (group 4), and protamine plus heparin (group 5). Formation of a protein corona was characterized by means of dynamic light scattering, ζ potential, and liquid chromatography-mass spectrometry...
November 1, 2017: Radiology
https://www.readbyqxmd.com/read/29090582/variability-of-complement-response-toward-preclinical-and-clinical-nanocarriers-in-the-general-population
#11
Halli Benasutti, Guankui Wang, Vivian P Vu, Robert Scheinman, Ernest Groman, Laura Saba, Dmitri Simberg
Opsonization (coating) of nanoparticles with complement C3 component is an important mechanism that triggers immune clearance and downstream anaphylactic and proinflammatory responses. The variability of complement C3 binding to nanoparticles in the general population has not been studied. We examined complement C3 binding to dextran superparamagnetic iron oxide nanoparticles (superparamagnetic iron oxide nanoworms, SPIO NWs, 58 and 110 nm) and clinically approved nanoparticles (carboxymethyl dextran iron oxide ferumoxytol (Feraheme, 28 nm), highly PEGylated liposomal doxorubicin (LipoDox, 88 nm), and minimally PEGylated liposomal irinotecan (Onivyde, 120 nm)) in sera from healthy human individuals...
November 1, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29071194/prediction-of-anti-cancer-nanotherapy-efficacy-by-imaging
#12
REVIEW
Miles A Miller, Sean Arlauckas, Ralph Weissleder
Anticancer nanotherapeutics have shown mixed results in clinical trials, raising the questions of whether imaging should be used to i) identify patients with a higher likelihood of nanoparticle accumulation, ii) assess nanotherapeutic efficacy before traditional measures show response, and iii) guide adjuvant treatments to enhance therapeutic nanoparticle (TNP) delivery. Here we review the use of a clinically approved MRI nanoparticle (ferumoxytol, FMX) to predict TNP delivery and efficacy. It is becoming increasingly apparent that nanoparticles used for imaging, despite clearly distinct physicochemical properties, often co-localize with TNP in tumors...
2017: Nanotheranostics
https://www.readbyqxmd.com/read/29040038/ferumoxytol-enhanced-mr-angiography-for-vascular-access-mapping-before-transcatheter-aortic-valve-replacement-in-patients-with-renal-impairment-a-step-toward-patient-specific-care
#13
Kim-Lien Nguyen, John M Moriarty, Adam N Plotnik, Olcay Aksoy, Takegawa Yoshida, Richard J Shemin, William M Suh, J Paul Finn
Purpose To assess the technical feasibility of the use of ferumoxytol-enhanced (FE) magnetic resonance (MR) angiography for vascular mapping before transcatheter aortic valve replacement in patients with renal impairment. Materials and Methods This was an institutional review board-approved and HIPAA-compliant study. FE MR angiography was performed at 3.0 T or 1.5 T. Unenhanced computed tomographic (CT) images were used to overlay vascular calcification on FE MR angiographic images as composite fused three-dimensional data...
October 16, 2017: Radiology
https://www.readbyqxmd.com/read/29035540/targetable-clinical-nanoparticles-for-precision-cancer-therapy-based-on-disease-specific-molecular-inflection-points
#14
Charalambos Kaittanis, Alexander Bolaender, Barney Yoo, Nilesh Shah, Ouathek Ouerfelli, Jan Grimm
Novel translational approaches based on clinical modular nanoplatforms are needed in order to treat solid cancers according to their discrete molecular features. In the present study, we show that the clinical nanopharmaceutical Ferumoxytol, which consists of a glucose-based coat surrounding an iron oxide core, could identify molecular characteristics of prostate cancer, corresponding to unique phases of the disease continuum. By affixing a targeting probe for the prostate-specific membrane antigen on its surface, the nanopharmaceutical was able to assess the functional state of the androgen receptor pathway via MRI, guiding therapy and delivering it with the same clinical nanoparticle...
November 8, 2017: Nano Letters
https://www.readbyqxmd.com/read/29033620/comparative-safety-of-intravenous-ferumoxytol-versus-ferric-carboxymaltose-for-the-treatment-of-iron-deficiency-anemia-rationale-and-study-design-of-a-randomized-double-blind-study-with-a-focus-on-acute-hypersensitivity-reactions
#15
N Franklin Adkinson, William E Strauss, Kristine Bernard, Robert F Kaper, Iain C Macdougall, Julie S Krop
BACKGROUND: Intravenous (IV) iron is often used to treat iron deficiency anemia in patients who are unable to tolerate or are inadequately managed with oral iron. However, IV iron treatment has been associated with acute hypersensitivity reactions. The comparative risk of adverse events (AEs) with IV iron preparations has been assessed by a few randomized controlled trials, which are most often limited by small patient numbers, which lack statistical power to identify differences in low-frequency AE such as hypersensitivity reactions...
2017: Journal of Blood Medicine
https://www.readbyqxmd.com/read/29033594/cost-effectiveness-analysis-of-intravenous-ferumoxytol-for-the-treatment-of-iron-deficiency-anemia-in-adult-patients-with-non-dialysis-dependent-chronic-kidney-disease-in-the-usa
#16
Naomi V Dahl, Robert F Kaper, William E Strauss, Frank A Corvino, Marko Zivkovic
OBJECTIVE: Ferumoxytol has demonstrated superior efficacy compared with oral iron in treating iron deficiency anemia in chronic kidney disease (CKD) patients. However, an economic evaluation of ferumoxytol has not been conducted. The aim of this study was to analyze the cost-effectiveness of treating iron deficiency anemia in adult non-dialysis-dependent CKD patients with ferumoxytol as compared with oral iron, alone or in combination with erythropoietin-stimulating agents (ESAs). METHODS: A decision analytic model compared health outcomes and costs associated with 5-week outpatient treatment of adult non-dialysis-dependent CKD patients with ferumoxytol or oral iron, each as monotherapy or in combination with ESAs in the USA...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28986407/ferumoxytol-enhanced-magnetic-resonance-imaging-in-acute-myocarditis
#17
Colin G Stirrat, Shirjel R Alam, Thomas J MacGillivray, Calum D Gray, Marc R Dweck, Kevin Dibb, Nick Spath, John R Payne, Sanjay K Prasad, Roy S Gardner, Saeed Mirsadraee, Peter A Henriksen, Scott Ik Semple, David E Newby
OBJECTIVES: Ultrasmall superparamagnetic particles of iron oxide (USPIO)-enhanced MRI can detect tissue-resident macrophage activity and identify cellular inflammation within tissues. We hypothesised that USPIO-enhanced MRI would provide a non-invasive imaging technique that would improve the diagnosis and management of patients with acute myocarditis. METHODS: Ten volunteers and 14 patients with suspected acute myocarditis underwent T2, T2* and late gadolinium enhancement (LGE) 3T MRI, with further T2* imaging at 24 hours after USPIO (ferumoxytol, 4 mg/kg) infusion, at baseline and 3 months...
October 6, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28973554/neurovascular-unit-basic-and-clinical-imaging-with-emphasis-on-advantages-of-ferumoxytol
#18
Joao Prola Netto, Jeffrey Iliff, Danica Stanimirovic, Kenneth A Krohn, Bronwyn Hamilton, Csanad Varallyay, Seymur Gahramanov, Heike Daldrup-Link, Christopher d'Esterre, Berislav Zlokovic, Haris Sair, Yueh Lee, Saeid Taheri, Rajan Jain, Ashok Panigrahy, Daniel S Reich, Lester R Drewes, Mauricio Castillo, Edward A Neuwelt
Physiological and pathological processes that increase or decrease the central nervous system's need for nutrients and oxygen via changes in local blood supply act primarily at the level of the neurovascular unit (NVU). The NVU consists of endothelial cells, associated blood-brain barrier tight junctions, basal lamina, pericytes, and parenchymal cells, including astrocytes, neurons, and interneurons. Knowledge of the NVU is essential for interpretation of central nervous system physiology and pathology as revealed by conventional and advanced imaging techniques...
July 21, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28925297/comment-intravenous-ferumoxytol-in-pediatric-patients-with-iron-deficiency-anemia
#19
Anna Butcher
No abstract text is available yet for this article.
September 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28885746/pseudo-extravasation-rate-constant-of-dynamic-susceptibility-contrast-mri-determined-from-pharmacokinetic-first-principles
#20
Xin Li, Csanad G Varallyay, Seymur Gahramanov, Rongwei Fu, William D Rooney, Edward A Neuwelt
Dynamic susceptibility contrast-magnetic resonance imaging (DSC-MRI) is widely used to obtain informative perfusion imaging biomarkers, such as the relative cerebral blood volume (rCBV). The related post-processing software packages for DSC-MRI are available from major MRI instrument manufacturers and third-party vendors. One unique aspect of DSC-MRI with low-molecular-weight gadolinium (Gd)-based contrast reagent (CR) is that CR molecules leak into the interstitium space and therefore confound the DSC signal detected...
September 8, 2017: NMR in Biomedicine
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