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Ferumoxytol

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https://www.readbyqxmd.com/read/28275562/a-comprehensive-literatures-update-of-clinical-researches-of-superparamagnetic-resonance-iron-oxide-nanoparticles-for-magnetic-resonance-imaging
#1
REVIEW
Yì Xiáng J Wáng, Jean-Marc Idée
This paper aims to update the clinical researches using superparamagnetic iron oxide (SPIO) nanoparticles as magnetic resonance imaging (MRI) contrast agent published during the past five years. PubMed database was used for literature search, and the search terms were (SPIO OR superparamagnetic iron oxide OR Resovist OR Ferumoxytol OR Ferumoxtran-10) AND (MRI OR magnetic resonance imaging). The literature search results show clinical research on SPIO remains robust, particularly fuelled by the approval of ferumoxytol for intravenously administration...
February 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28214127/functionalized-superparamagnetic-iron-oxide-nanoparticles-provide-highly-efficient-iron-labeling-in-macrophages-for-magnetic-resonance-based-detection-in-vivo
#2
Jack Sharkey, Philip J Starkey Lewis, Michael Barrow, Salamah M Alwahsh, June Noble, Eilidh Livingstone, Ross J Lennen, Maurits A Jansen, Jaime Garcia Carrion, Neill Liptrott, Shareen Forbes, Dave J Adams, Amy E Chadwick, Stuart J Forbes, Patricia Murray, Matthew J Rosseinsky, Christopher E Goldring, B Kevin Park
BACKGROUND AIMS: Tracking cells during regenerative cytotherapy is crucial for monitoring their safety and efficacy. Macrophages are an emerging cell-based regenerative therapy for liver disease and can be readily labeled for medical imaging. A reliable, clinically applicable cell-tracking agent would be a powerful tool to study cell biodistribution. METHODS: Using a recently described chemical design, we set out to functionalize, optimize and characterize a new set of superparamagnetic iron oxide nanoparticles (SPIONs) to efficiently label macrophages for magnetic resonance imaging-based cell tracking in vivo...
April 2017: Cytotherapy
https://www.readbyqxmd.com/read/28170192/ferumoxytol-labeling-of-human-neural-progenitor-cells-for-diagnostic-cellular-tracking-in-the-porcine-spinal-cord-with-magnetic-resonance-imaging
#3
Jason J Lamanna, Juanmarco Gutierrez, Lindsey N Urquia, C Victor Hurtig, Elman Amador, Natalia Grin, Clive N Svendsen, Thais Federici, John N Oshinski, Nicholas M Boulis
We report on the diagnostic capability of magnetic resonance imaging (MRI)-based tracking of ferumoxytol-labeled human neural progenitor cells (hNPCs) transplanted into the porcine spinal cord. hNPCs prelabeled with two doses of ferumoxytol nanoparticles (hNPC-F(Low) and hNPC-F(High) ) were injected into the ventral horn of the spinal cord in healthy minipigs. Ferumoxytol-labeled grafts were tracked in vivo up to 105 days after transplantation with MRI. Injection accuracy was assessed in vivo at day 14 and was predictive of "on" or "off" target cell graft location assessed by histology...
January 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28160356/ferumoxytol-vs-gadolinium-agents-for-contrast-enhanced-mri-thoughts-on-evolving-indications-risks-and-benefits
#4
J Paul Finn, Kim-Lien Nguyen, Peng Hu
No abstract text is available yet for this article.
February 3, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28159813/correlation-between-ferumoxytol-uptake-in-tumor-lesions-by-mri-and-response-to-nanoliposomal-irinotecan-in-patients-with-advanced-solid-tumors-a-pilot-study
#5
Ramesh K Ramanathan, Ronald Korn, Natarajan Raghunand, Jasgit C Sachdev, Ronald G Newbold, Gayle Jameson, Gerald J Fetterly, Joshua Prey, Stephan G Klinz, Jaeyeon Kim, Jason Cain, Bart S Hendriks, Daryl C Drummond, Eliel Bayever, Jonathan B Fitzgerald
PURPOSE: Determine if deposition characteristics of ferumoxytol (FMX) iron nanoparticles in tumors, identified by quantitative MRI, may predict tumor lesion response to nanoliposomal irinotecan (nal-IRI). EXPERIMENTAL DESIGN: Eligible patients with previously treated solid tumors had FMX-MRI scans before and following (1, 24, and 72 hours) FMX injection. After MRI acquisition, R2* signal was used to calculate FMX levels in plasma, reference tissue and tumor lesions by comparison with a phantom-based standard curve...
February 3, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28150359/potential-role-of-tracing-stem-cell-transplantation-and-effects-on-the-immune-cell-function-of-ferumoxytol-combining-with-heparin-and-protamine-in-vivo-in-vitro
#6
Jingyuan Zhao, Xin Guan, Yang Liu, Hua Piao, Rutao Liu, Xiang Zhou, Bo Sun, Yue Du, Jing Liu
Cell labeling and tracing have played an increasingly important role in the field of stem cell transplantation. Nanocomplexes combining three Food and Drug Administration (FDA)-approved drugs: heparin (H), protamine (P), and ferumoxytol (F) (HPF nanocomplexes) display high labeling efficiency in human adipose tissue-derived stem cells (hADSCs), but their biological safety has not been determined. In this study, we tested the labeling efficiency of HPF in hADSCs through in vitro cytotoxicity studies and in vivo murine preclinical studies using HPF-labeled hADSCs...
February 2, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28135334/relative-incidence-of-acute-adverse-events-with-ferumoxytol-compared-to-other-intravenous-iron-compounds-a-matched-cohort-study
#7
James B Wetmore, Eric D Weinhandl, Jincheng Zhou, David T Gilbertson
Concerns persist about adverse reactions to intravenous (IV) iron. We aimed to determine the relative safety of ferumoxytol compared to other IV iron compounds. This retrospective cohort study with propensity-score matching for patients and drug doses used the Medicare 20% random sample to identify patients (1) without chronic kidney disease (non-CKD) and (2) with non-dialysis-dependent chronic kidney disease (NDD-CKD) who received a first dose of IV iron in 2010-2012. Exposures were ferumoxytol, iron sucrose, sodium ferric gluconate, or iron dextran...
2017: PloS One
https://www.readbyqxmd.com/read/28132063/magnetic-resonance-imaging-guided-transplantation-of-neural-stem-cells-into-the-porcine-spinal-cord
#8
Jason J Lamanna, Lindsey N Urquia, Carl V Hurtig, Juanmarco Gutierrez, Cody Anderson, Pete Piferi, Thais Federici, John N Oshinski, Nicholas M Boulis
BACKGROUND: Cell-based therapies are a promising treatment option for traumatic, tumorigenic and degenerative diseases of the spinal cord. Transplantation into the spinal cord is achieved with intravascular, intrathecal, or direct intraparenchymal injection. The current standard for direct injection is limited by surgical invasiveness, difficulty in reinjection, and the inability to directly target anatomical or pathological landmarks. The objective of this study was to present the proof of principle for minimally invasive, percutaneous transplantation of stem cells into the spinal cord parenchyma of live minipigs under MR guidance...
2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28128708/detection-of-stem-cell-transplant-rejection-with-ferumoxytol-mr-imaging-correlation-of-mr-imaging-findings-with-those-at-intravital-microscopy
#9
Heike E Daldrup-Link, Carmel Chan, Olga Lenkov, Seyedmeghdad Taghavigarmestani, Toktam Nazekati, Hossein Nejadnik, Fanny Chapelin, Aman Khurana, Xinming Tong, Fan Yang, Laura Pisani, Michael Longaker, Sanjiv Sam Gambhir
Purpose To determine whether endogenous labeling of macrophages with clinically applicable nanoparticles enables noninvasive detection of innate immune responses to stem cell transplants with magnetic resonance (MR) imaging. Materials and Methods Work with human stem cells was approved by the institutional review board and the stem cell research oversight committee, and animal experiments were approved by the administrative panel on laboratory animal care. Nine immunocompetent Sprague-Dawley rats received intravenous injection of ferumoxytol, and 18 Jax C57BL/6-Tg (Csf1r-EGFP-NGFR/FKBP1A/TNFRSF6) 2Bck/J mice received rhodamine-conjugated ferumoxytol...
January 27, 2017: Radiology
https://www.readbyqxmd.com/read/28100426/ferumoxytol-mra-for-transcatheter-aortic-valve-replacement-planning-with-renal-insufficiency
#10
Kimberly Kallianos, Travis S Henry, Yerem Yeghiazarians, Jeffrey Zimmet, Kendrick A Shunk, Elaine E Tseng, Vaikom Mahadevan, Michael D Hope
BACKGROUND: Computed tomography angiography (CTA) is the test of choice for pre-procedure imaging of transcatheter aortic valve replacement (TAVR) candidates. The iodinated contrast required, however, increases the risk of renal dysfunction in patients with pre-existing renal failure. Ferumoxytol is a magnetic resonance imaging (MRI) contrast agent that can be used with renal failure. Its long vascular resonance time allows gated MRA sequences that approach CTA in image quality. We present respiratory and cardiac gated MRA enabled by ferumoxytol that can be post-processed in an analogous fashion to CTA...
March 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28017584/feasibility-of-three-dimensional-magnetic-resonance-angiography-fluoroscopy-image-fusion-technique-in-guiding-complex-endovascular-aortic-procedures-in-patients-with-renal-insufficiency
#11
Adeline Schwein, Ponraj Chinnadurai, Dipan J Shah, Alan B Lumsden, Carlos F Bechara, Jean Bismuth
OBJECTIVE: Three-dimensional image fusion of preoperative computed tomography (CT) angiography with fluoroscopy using intraoperative noncontrast cone-beam CT (CBCT) has been shown to improve endovascular procedures by reducing procedure length, radiation dose, and contrast media volume. However, patients with a contraindication to CT angiography (renal insufficiency, iodinated contrast allergy) may not benefit from this image fusion technique. The primary objective of this study was to evaluate the feasibility of magnetic resonance angiography (MRA) and fluoroscopy image fusion using noncontrast CBCT as a guidance tool during complex endovascular aortic procedures, especially in patients with renal insufficiency...
December 23, 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27998280/misleading-early-blood-volume-changes-obtained-using-ferumoxytol-based-magnetic-resonance-imaging-perfusion-in-high-grade-glial-neoplasms-treated-with-bevacizumab
#12
Joao Prola Netto, Daniel Schwartz, Csanad Varallyay, Rongwei Fu, Bronwyn Hamilton, Edward A Neuwelt
BACKGROUND: Neovascularization, a distinguishing trait of high-grade glioma, is a target for anti-angiogenic treatment with bevacizumab (BEV). This study sought to use ferumoxytol-based dynamic susceptibility contrast magnetic resonance imaging (MRI) to clarify perfusion and relative blood volume (rCBV) changes in glioma treated with BEV and to determine potential impact on clinical management. METHODS: 16 high grade glioma patients who received BEV following post-chemoradiation radiographic or clinical progression were included...
December 20, 2016: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/27940247/sdf-1-blockade-enhances-anti-vegf-therapy-of-glioblastoma-and-can-be-monitored-by-mri
#13
Lei Deng, Jason H Stafford, Shie-Chau Liu, Sophia B Chernikova, Milton Merchant, Lawrence Recht, J Martin Brown
Despite the approval of antiangiogenic therapy for glioblastoma multiforme (GBM) patients, survival benefits are still limited. One of the resistance mechanisms for antiangiogenic therapy is the induction of hypoxia and subsequent recruitment of macrophages by stromal-derived factor (SDF)-1α (CXCL-12). In this study, we tested whether olaptesed pegol (OLA-PEG, NOX-A12), a novel SDF-1α inhibitor, could reverse the recruitment of macrophages and potentiate the antitumor effect of anti-vascular endothelial growth factor (VEGF) therapy...
December 7, 2016: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/27889746/distinct-in-vitro-complement-activation-by-various-intravenous-iron-preparations
#14
Julia Cordelia Hempel, Felix Poppelaars, Mariana Gaya da Costa, Casper F M Franssen, Thomas P G de Vlaam, Mohamed R Daha, Stefan P Berger, Marc A J Seelen, Carlo A J M Gaillard
BACKGROUND: Intravenous (IV) iron preparations are widely used in the treatment of anemia in patients undergoing hemodialysis (HD). All IV iron preparations carry a risk of causing hypersensitivity reactions. However, the pathophysiological mechanism is poorly understood. We hypothesize that a relevant number of these reactions are mediated by complement activation, resulting in a pseudo-anaphylactic clinical picture known as complement activation-related pseudo allergy (CARPA). METHODS: First, the in-vitro complement-activating capacity was determined for 5 commonly used IV iron preparations using functional complement assays for the 3 pathways...
2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/27862577/crossover-comparison-of-ferumoxytol-and-gadobenate-dimeglumine-for-abdominal-mr-angiography-at-3-0-tesla-effects-of-contrast-bolus-length-and-flip-angle
#15
Tilman Schubert, Utaroh Motosugi, Sonja Kinner, Timothy J Colgan, Samir D Sharma, Scott Hetzel, Shane Wells, Camilo A Campo, Scott B Reeder
PURPOSE: Ferumoxytol (FE) has gained interest as an alternative to gadolinium-based contrast agents (GBCAs). The purpose of this study was to evaluate and optimize ferumoxytol dose and T1 weighting, in comparison to a conventional GBCA. MATERIALS AND METHODS: Twelve healthy volunteers (six women / six men, mean age 44.3 years) were recruited for this study. Scanning was performed on a clinical 3 Tesla (T) MRI system. Gadobenate dimeglumine (GD)-enhanced MRA was performed followed by FE-enhanced MRA 1 month later...
November 10, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27862507/accelerated-ferumoxytol-enhanced-4d-multiphase-steady-state-imaging-with-contrast-enhancement-music-cardiovascular-mri-validation-in-pediatric-congenital-heart-disease
#16
Ziwu Zhou, Fei Han, Stanislas Rapacchi, Kim-Lien Nguyen, Daniel Z Brunengraber, Grace-Hyun J Kim, J Paul Finn, Peng Hu
The purpose of this work was to validate a parallel imaging (PI) and compressed sensing (CS) combined reconstruction method for a recently proposed 4D non-breath-held, multiphase, steady-state imaging technique (MUSIC) cardiovascular MRI in a cohort of pediatric congenital heart disease patients. We implemented a graphics processing unit accelerated CS-PI combined reconstruction method and applied it in 13 pediatric patients who underwent cardiovascular MRI after ferumoxytol administration. Conventional breath-held contrast-enhanced magnetic resonance angiography (CE-MRA) was first performed during the first pass of ferumoxytol injection, followed by the original MUSIC and the proposed CS-PI MUSIC during the steady-state distribution phase of ferumoxytol...
January 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/27799546/in-vivo-nanoparticle-imaging-of-innate-immune-cells-can-serve-as-a-marker-of-disease-severity-in-a-model-of-multiple-sclerosis
#17
Klara Kirschbaum, Jana K Sonner, Matthias W Zeller, Katrin Deumelandt, Julia Bode, Rakesh Sharma, Thomas Krüwel, Manuel Fischer, Angelika Hoffmann, Milene Costa da Silva, Martina U Muckenthaler, Wolfgang Wick, Björn Tews, John W Chen, Sabine Heiland, Martin Bendszus, Michael Platten, Michael O Breckwoldt
Innate immune cells play a key role in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). Current clinical imaging is restricted to visualizing secondary effects of inflammation, such as gliosis and blood-brain barrier disruption. Advanced molecular imaging, such as iron oxide nanoparticle imaging, can allow direct imaging of cellular and molecular activity, but the exact cell types that phagocytose nanoparticles in vivo and how phagocytic activity relates to disease severity is not well understood...
November 15, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27781154/intranodal-signal-suppression-in-pelvic-mr-lymphography-of-prostate-cancer-patients-a-quantitative-comparison-of-ferumoxtran-10-and-ferumoxytol
#18
Oscar A Debats, Ansje S Fortuin, Hanneke J M Meijer, Thomas Hambrock, Geert J S Litjens, Jelle O Barentsz, Henkjan J Huisman
OBJECTIVES: The key to MR lymphography is suppression of T2* MR signal in normal lymph nodes, while retaining high signal in metastatic nodes. Our objective is to quantitatively compare the ability of ferumoxtran-10 and ferumoxytol to suppress the MR signal in normal pelvic lymph nodes. METHODS: In 2010, a set of consecutive patients who underwent intravenous MR Lymphography (MRL) were included. Signal suppression in normal lymph nodes in T2*-weighted images due to uptake of USPIO (Ultra-Small Superparamagnetic Particles of Iron Oxide) was quantified...
2016: PeerJ
https://www.readbyqxmd.com/read/27775841/evaluation-of-an-fmri-uspio-based-assay-in-healthy-human-volunteers
#19
Richard Baumgartner, William Cho, Alexandre Coimbra, Christopher Chen, Zaiqi Wang, Arie Struyk, Narayanaswamy Venketasubramanian, May Low, Cindy Gargano, Fuqiang Zhao, Donald Williams, Torsten Reese, Stephanie Seah, Dai Feng, Sonya Apreleva, Esben Petersen, Jeffrey L Evelhoch
PURPOSE: To present the testretest and contrast dose effect results of cerebral blood volume (CBV) functional MRI (fMRI) in healthy human volunteers using ferumoxytol (Feraheme), an ultrasmall-superparamagnetic iron oxide (USPIO) nanoparticle. MATERIALS AND METHODS: This was an open-label, two-period, fixed-sequence study in healthy young volunteers. In eight subjects, using a 3 Tesla field strength system, blood oxygen level dependent (BOLD) and CBV fMRI were acquired in response to a visual black-and-white checkboard stimulation paradigm using an escalating ferumoxytol dose design (250, 350, and 510 mg iron)...
October 24, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27768618/absent-vascular-signal-on-time-of-flight-magnetic-resonance-angiography-due-to-recent-ferumoxytol-infusion
#20
Aparna Singhal, Joel K Curé
Time-of-flight magnetic resonance angiography is used for craniocervical arterial evaluation. Absent flow-related signal may be the result of slow flow, complex flow, or focal susceptibility effects. We report a case with complete absence of flow-related signal in the intracranial and cervical vessels due to ferumoxytol infusion given 5 days before magnetic resonance angiography. Ferumoxytol is a newly approved parenteral therapy for iron-deficiency anemia in patients with renal failure and awareness of this drug-magnetic resonance imaging interaction is needed...
March 2017: Journal of Computer Assisted Tomography
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