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Ferumoxytol

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https://www.readbyqxmd.com/read/27889746/distinct-in-vitro-complement-activation-by-various-intravenous-iron-preparations
#1
Julia Cordelia Hempel, Felix Poppelaars, Mariana Gaya da Costa, Casper F M Franssen, Thomas P G de Vlaam, Mohamed R Daha, Stefan P Berger, Marc A J Seelen, Carlo A J M Gaillard
BACKGROUND: Intravenous (IV) iron preparations are widely used in the treatment of anemia in patients undergoing hemodialysis (HD). All IV iron preparations carry a risk of causing hypersensitivity reactions. However, the pathophysiological mechanism is poorly understood. We hypothesize that a relevant number of these reactions are mediated by complement activation, resulting in a pseudo-anaphylactic clinical picture known as complement activation-related pseudo allergy (CARPA). METHODS: First, the in-vitro complement-activating capacity was determined for 5 commonly used IV iron preparations using functional complement assays for the 3 pathways...
November 26, 2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27862577/crossover-comparison-of-ferumoxytol-and-gadobenate-dimeglumine-for-abdominal-mr-angiography-at-3-0-tesla-effects-of-contrast-bolus-length-and-flip-angle
#2
Tilman Schubert, Utaroh Motosugi, Sonja Kinner, Timothy J Colgan, Samir D Sharma, Scott Hetzel, Shane Wells, Camilo A Campo, Scott B Reeder
PURPOSE: Ferumoxytol (FE) has gained interest as an alternative to gadolinium-based contrast agents (GBCAs). The purpose of this study was to evaluate and optimize ferumoxytol dose and T1 weighting, in comparison to a conventional GBCA. MATERIALS AND METHODS: Twelve healthy volunteers (six women / six men, mean age 44.3 years) were recruited for this study. Scanning was performed on a clinical 3 Tesla (T) MRI system. Gadobenate dimeglumine (GD)-enhanced MRA was performed followed by FE-enhanced MRA 1 month later...
November 10, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27862507/accelerated-ferumoxytol-enhanced-4d-multiphase-steady-state-imaging-with-contrast-enhancement-music-cardiovascular-mri-validation-in-pediatric-congenital-heart-disease
#3
Ziwu Zhou, Fei Han, Stanislas Rapacchi, Kim-Lien Nguyen, Daniel Z Brunengraber, Grace-Hyun J Kim, J Paul Finn, Peng Hu
The purpose of this work was to validate a parallel imaging (PI) and compressed sensing (CS) combined reconstruction method for a recently proposed 4D non-breath-held, multiphase, steady-state imaging technique (MUSIC) cardiovascular MRI in a cohort of pediatric congenital heart disease patients. We implemented a graphics processing unit accelerated CS-PI combined reconstruction method and applied it in 13 pediatric patients who underwent cardiovascular MRI after ferumoxytol administration. Conventional breath-held contrast-enhanced magnetic resonance angiography (CE-MRA) was first performed during the first pass of ferumoxytol injection, followed by the original MUSIC and the proposed CS-PI MUSIC during the steady-state distribution phase of ferumoxytol...
November 11, 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27799546/in-vivo-nanoparticle-imaging-of-innate-immune-cells-can-serve-as-a-marker-of-disease-severity-in-a-model-of-multiple-sclerosis
#4
Klara Kirschbaum, Jana K Sonner, Matthias W Zeller, Katrin Deumelandt, Julia Bode, Rakesh Sharma, Thomas Krüwel, Manuel Fischer, Angelika Hoffmann, Milene Costa da Silva, Martina U Muckenthaler, Wolfgang Wick, Björn Tews, John W Chen, Sabine Heiland, Martin Bendszus, Michael Platten, Michael O Breckwoldt
Innate immune cells play a key role in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). Current clinical imaging is restricted to visualizing secondary effects of inflammation, such as gliosis and blood-brain barrier disruption. Advanced molecular imaging, such as iron oxide nanoparticle imaging, can allow direct imaging of cellular and molecular activity, but the exact cell types that phagocytose nanoparticles in vivo and how phagocytic activity relates to disease severity is not well understood...
November 15, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27781154/intranodal-signal-suppression-in-pelvic-mr-lymphography-of-prostate-cancer-patients-a-quantitative-comparison-of-ferumoxtran-10-and-ferumoxytol
#5
Oscar A Debats, Ansje S Fortuin, Hanneke J M Meijer, Thomas Hambrock, Geert J S Litjens, Jelle O Barentsz, Henkjan J Huisman
OBJECTIVES: The key to MR lymphography is suppression of T2* MR signal in normal lymph nodes, while retaining high signal in metastatic nodes. Our objective is to quantitatively compare the ability of ferumoxtran-10 and ferumoxytol to suppress the MR signal in normal pelvic lymph nodes. METHODS: In 2010, a set of consecutive patients who underwent intravenous MR Lymphography (MRL) were included. Signal suppression in normal lymph nodes in T2*-weighted images due to uptake of USPIO (Ultra-Small Superparamagnetic Particles of Iron Oxide) was quantified...
2016: PeerJ
https://www.readbyqxmd.com/read/27775841/evaluation-of-an-fmri-uspio-based-assay-in-healthy-human-volunteers
#6
Richard Baumgartner, William Cho, Alexandre Coimbra, Christopher Chen, Zaiqi Wang, Arie Struyk, Narayanaswamy Venketasubramanian, May Low, Cindy Gargano, Fuqiang Zhao, Donald Williams, Torsten Reese, Stephanie Seah, Dai Feng, Sonya Apreleva, Esben Petersen, Jeffrey L Evelhoch
PURPOSE: To present the testretest and contrast dose effect results of cerebral blood volume (CBV) functional MRI (fMRI) in healthy human volunteers using ferumoxytol (Feraheme), an ultrasmall-superparamagnetic iron oxide (USPIO) nanoparticle. MATERIALS AND METHODS: This was an open-label, two-period, fixed-sequence study in healthy young volunteers. In eight subjects, using a 3 Tesla field strength system, blood oxygen level dependent (BOLD) and CBV fMRI were acquired in response to a visual black-and-white checkboard stimulation paradigm using an escalating ferumoxytol dose design (250, 350, and 510 mg iron)...
October 24, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27768618/absent-vascular-signal-on-time-of-flight-magnetic-resonance-angiography-due-to-recent-ferumoxytol-infusion
#7
Aparna Singhal, Joel K Curé
Time-of-flight magnetic resonance angiography is used for craniocervical arterial evaluation. Absent flow-related signal may be the result of slow flow, complex flow, or focal susceptibility effects. We report a case with complete absence of flow-related signal in the intracranial and cervical vessels due to ferumoxytol infusion given 5 days before magnetic resonance angiography. Ferumoxytol is a newly approved parenteral therapy for iron-deficiency anemia in patients with renal failure and awareness of this drug-magnetic resonance imaging interaction is needed...
October 20, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27757917/magnetic-resonance-imaging-of-ferumoxytol-labeled-human-mesenchymal-stem-cells-in-the-mouse-brain
#8
Na Kyung Lee, Hyeong Seop Kim, Dongkyeom Yoo, Jung Won Hwang, Soo Jin Choi, Wonil Oh, Jong Wook Chang, Duk L Na
The success of stem cell therapy is highly dependent on accurate delivery of stem cells to the target site of interest. Possible ways to track the distribution of MSCs in vivo include the use of reporter genes or nanoparticles. The U.S. Food and Drug Administration (FDA) has approved ferumoxytol (Feraheme® [USA], Rienso® [UK]) as a treatment for iron deficiency anemia. Ferumoxytol is an ultrasmall superparamagnetic iron oxide nanoparticle (USPIO) that has recently been used to track the fate of transplanted cells using magnetic resonance imaging (MRI)...
October 18, 2016: Stem Cell Reviews
https://www.readbyqxmd.com/read/27751347/noninvasive-assessment-of-losartan-induced-increase-in-functional-microvasculature-and-drug-delivery-in-pancreatic-ductal-adenocarcinoma
#9
Vidhya Kumar, Yves Boucher, Hao Liu, Diego Ferreira, Jacob Hooker, Ciprian Catana, Andrew J Hoover, Tobias Ritter, Rakesh K Jain, Alexander R Guimaraes
PURPOSE: Losartan, an angiotensin II receptor blocker, can reduce desmoplasia and enhance drug delivery and efficacy through improving interstitial transport and vascular perfusion in pancreatic ductal adenocarcinoma (PDAC) models in mice. The purpose of this study was to determine whether magnetic resonance imaging (MRI) of magnetic iron oxide nanoparticles (MNPs) and micro-positron emission tomography (PET) measurements could respectively detect improvements in tumor vascular parameters and drug uptake in orthotopic PDAC in mice treated with losartan...
October 2016: Translational Oncology
https://www.readbyqxmd.com/read/27704163/incidental-ferumoxytol-artifacts-in-clinical-brain-mr-imaging
#10
Bruce A Bowser, Norbert G Campeau, Carrie M Carr, Felix E Diehn, Jennifer S McDonald, Gary M Miller, Timothy J Kaufmann
INTRODUCTION: Ferumoxytol (Feraheme) is a parenteral therapy approved for treatment of iron deficiency anemia. The product insert for ferumoxytol states that it may affect the diagnostic ability of MRI for up to 3 months. However, the expected effects may not be commonly recognized among clinical neuroradiologists. Our purpose is to describe the artifacts we have seen at our institution during routine clinical practice. METHODS: We reviewed the patients at our institution that had brain MRI performed within 90 days of receiving intravenous ferumoxytol...
October 4, 2016: Neuroradiology
https://www.readbyqxmd.com/read/27678106/feasibility-of-ferumoxytol-enhanced-neonatal-and-young-infant-cardiac-mri-without-general-anesthesia
#11
Lillian M Lai, Joseph Y Cheng, Marcus T Alley, Tao Zhang, Michael Lustig, Shreyas S Vasanawala
PURPOSE: To assess the feasibility of ferumoxytol-enhanced anesthesia-free cardiac MRI in neonates and young infants for complex congenital heart disease (CHD). MATERIALS AND METHODS: With Institutional Review Board approval, 21 consecutive neonates and young infants (1 day to 11 weeks old; median age of 3 days) who underwent a rapid two-sequence (MR angiography [MRA] and four-dimensional [4D] flow) MRI protocol with intravenous ferumoxytol without sedation (n = 17) or light sedation (n = 4) at 3 Tesla (T) (except one case at 1...
September 28, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27675056/the-use-of-ferumoxytol-and-t2-weighted-magnetic-resonance-imaging-for-noninvasive-assessment-of-changes-in-tumor-vascularity-during-radiation-therapy
#12
K C Lee, S A Krueger, K Buelow, S Galoforo, J Torma, I S Grills, G D Wilson, B Marples
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27668795/iron-oxide-nanoparticles-inhibit-tumour-growth-by-inducing-pro-inflammatory-macrophage-polarization-in-tumour-tissues
#13
Saeid Zanganeh, Gregor Hutter, Ryan Spitler, Olga Lenkov, Morteza Mahmoudi, Aubie Shaw, Jukka Sakari Pajarinen, Hossein Nejadnik, Stuart Goodman, Michael Moseley, Lisa Marie Coussens, Heike Elisabeth Daldrup-Link
Until now, the Food and Drug Administration (FDA)-approved iron supplement ferumoxytol and other iron oxide nanoparticles have been used for treating iron deficiency, as contrast agents for magnetic resonance imaging and as drug carriers. Here, we show an intrinsic therapeutic effect of ferumoxytol on the growth of early mammary cancers, and lung cancer metastases in liver and lungs. In vitro, adenocarcinoma cells co-incubated with ferumoxytol and macrophages showed increased caspase-3 activity. Macrophages exposed to ferumoxytol displayed increased mRNA associated with pro-inflammatory Th1-type responses...
November 2016: Nature Nanotechnology
https://www.readbyqxmd.com/read/27574329/ferumoxytol-labeling-of-human-neural-progenitor-cells-for-diagnostic-cellular-tracking-in-the-porcine-spinal-cord-with-magnetic-resonance-imaging
#14
Jason J Lamanna, Juanmarco Gutierrez, Lindsey N Urquia, C Victor Hurtig, Elman Amador, Natalia Grin, Clive N Svendsen, Thais Federici, John N Oshinski, Nicholas M Boulis
: : We report on the diagnostic capability of magnetic resonance imaging (MRI)-based tracking of ferumoxytol-labeled human neural progenitor cells (hNPCs) transplanted into the porcine spinal cord. hNPCs prelabeled with two doses of ferumoxytol nanoparticles (hNPC-F(Low) and hNPC-F(High)) were injected into the ventral horn of the spinal cord in healthy minipigs. Ferumoxytol-labeled grafts were tracked in vivo up to 105 days after transplantation with MRI. Injection accuracy was assessed in vivo at day 14 and was predictive of "on" or "off" target cell graft location assessed by histology...
August 29, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27571884/mri-monitoring-of-monocytes-to-detect-immune-stimulating-treatment-response-in-brain-tumor
#15
Runze Yang, Susobhan Sarkar, Daniel J Korchinski, Ying Wu, V Wee Yong, Jeff F Dunn
BACKGROUND: Glioblastoma (GBM) is an aggressive brain cancer with a poor prognosis. The use of immune therapies to treat GBM has become a promising avenue of research. It was shown that amphotericin B (Amp B) can stimulate the innate immune system and suppress the growth of brain tumor initiating cells (BTICs). However, it is not feasible to use histopathology to determine immune activation in patients. We developed an MRI technique that can rapidly detect a therapeutic response in animals treated with drugs that stimulate innate immunity...
August 29, 2016: Neuro-oncology
https://www.readbyqxmd.com/read/27529745/self-gated-4d-multiphase-steady-state-imaging-with-contrast-enhancement-music-using-rotating-cartesian-k-space-rock-validation-in-children-with-congenital-heart-disease
#16
Fei Han, Ziwu Zhou, Eric Han, Yu Gao, Kim-Lien Nguyen, J Paul Finn, Peng Hu
PURPOSE: To develop and validate a cardiac-respiratory self-gating strategy for the recently proposed multiphase steady-state imaging with contrast enhancement (MUSIC) technique. METHODS: The proposed SG strategy uses the ROtating Cartesian K-space (ROCK) sampling, which allows for retrospective k-space binning based on motion surrogates derived from k-space center line. The k-space bins are reconstructed using a compressed sensing algorithm. Ten pediatric patients underwent cardiac MRI for clinical reasons...
August 16, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27520728/physicochemical-characterization-of-ferumoxytol-heparin-and-protamine-nanocomplexes-for-improved-magnetic-labeling-of-stem-cells
#17
L Henry Bryant, Saejeong J Kim, Matthew Hobson, Blerta Milo, Zsofia I Kovacs, Neekita Jikiria, Bobbi K Lewis, Maria A Aronova, Alioscka A Sousa, Guofeng Zhang, Richard D Leapman, Joseph A Frank
Stem cell-based therapies have become a major focus in regenerative medicine and to treat diseases. A straightforward approach combining three drugs, heparin (H), protamine (P) with ferumoxytol (F) in the form of nanocomplexes (NCs) effectively labeled stem cells for cellular MRI. We report on the physicochemical characteristics for optimizing the H, P, and F components in different ratios, and mixing sequences, producing NCs that varied in hydrodynamic size. NC size depended on the order in which drugs were mixed in media...
August 9, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/27504713/comparison-of-ferumoxytol-enhanced-mra-with-conventional-angiography-for-assessment-of-severity-of-transplant-renal-artery-stenosis
#18
Ghaneh Fananapazir, Mustafa R Bashir, Michael T Corwin, Ramit Lamba, Catherine T Vu, Christoph Troppmann
PURPOSE: To determine the accuracy of ferumoxytol-enhanced magnetic resonance angiography (MRA) in assessing the severity of transplant renal artery stenosis (TRAS), using digital subtraction angiography (DSA) as the reference standard. MATERIALS AND METHODS: Our Institutional Review Board approved this retrospective, Health Insurance Portability and Accountability Act-compliant study. Thirty-three patients with documented clinical suspicion for TRAS (elevated serum creatinine, refractory hypertension, edema, and/or audible bruit) and/or concerning sonographic findings (elevated renal artery velocity and/or intraparenchymal parvus tardus waveforms) underwent a 1...
August 9, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27480885/mri-with-ferumoxytol-a-single-center-experience-of-safety-across-the-age-spectrum
#19
Kim-Lien Nguyen, Takegawa Yoshida, Fei Han, Ihab Ayad, Brian L Reemtsen, Isidro B Salusky, Gary M Satou, Peng Hu, J Paul Finn
PURPOSE: To summarize our single-center safety experience with the off-label use of ferumoxytol for magnetic resonance imaging (MRI) and to compare the effects of ferumoxytol on monitored physiologic indices in patients under anesthesia with those of gadofosveset trisodium. MATERIALS AND METHODS: Consecutive patients who underwent ferumoxytol-enhanced (FE) MRI exams were included. Adverse events (AEs) were classified according to the Common Terminology Criteria for Adverse Events v4...
August 2, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27468245/ferumoxytol-versus-placebo-in-iron-deficiency-anemia-efficacy-safety-and-quality-of-life-in-patients-with-gastrointestinal-disorders
#20
David C Ford, Naomi V Dahl, William E Strauss, Charles F Barish, David J Hetzel, Kristine Bernard, Zhu Li, Lee F Allen
INTRODUCTION: Iron deficiency anemia (IDA) is common in patients with gastrointestinal (GI) disorders and can adversely affect quality of life. Oral iron is poorly tolerated in many patients with GI disorders. Ferumoxytol is approved for the intravenous treatment of IDA in patients with chronic kidney disease. This study aimed to evaluate the efficacy and safety of ferumoxytol in patients with IDA and concomitant GI disorders. PATIENTS AND METHODS: This analysis included 231 patients with IDA and GI disorders from a Phase III, randomized, double-blind, placebo-controlled trial evaluating ferumoxytol (510 mg ×2) versus placebo in patients who had failed or were intolerant of oral iron therapy...
2016: Clinical and Experimental Gastroenterology
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