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Confocal laser endomicroscopy

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https://www.readbyqxmd.com/read/29286374/optical-screening-of-novel-bacteria-specific-probes-on-ex-vivo-human-lung-tissue-by-confocal-laser-endomicroscopy
#1
Bethany Mills, Ahsan R Akram, Emma Scholefield, Mark Bradley, Kevin Dhaliwal
Improving the speed and accuracy of bacterial detection is important for patient stratification and to ensure the appropriate use of antimicrobials. To achieve this goal, the development of diagnostic techniques to recognize bacterial presence in real-time at the point-of-care is required. Optical imaging for direct identification of bacteria within the host is an attractive approach. Several attempts at chemical probe design and validation have been investigated, however none have yet been successfully translated into the clinic...
November 29, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29277482/comparison-of-narrow-band-imaging-and-confocal-laser-endomicroscopy-for-the-detection-of-neoplasia-in-barrett-s-esophagus-a-meta-analysis
#2
Yi-Quan Xiong, Shu-Juan Ma, Hao-Yue Hu, Jing Ge, Li-Zhi Zhou, Shu-Ting Huo, Min Qiu, Qing Chen
AIMS: Barrett's esophagus (BE) predisposes to the development of esophageal neoplasia, including high-grade dysplasia (HGD) and esophageal adenocarcinoma (EAC). A systematic literature review and meta-analysis were performed to assess the accuracy of within-patient comparisons of narrow band imaging (NBI) and confocal laser endomicroscopy (CLE) for diagnosis of HGD/EAC in patients with BE. METHODS: The following databases were examined up to April 2016 without language restriction: PubMed, Embase, Medline, Web of Science and the Cochrane Library...
December 22, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29273725/functional-shift-with-maintained-regenerative-potential-following-portal-vein-ligation
#3
Tibor Kovács, Domokos Máthé, András Fülöp, Katalin Jemnitz, Attila Bátai-Konczos, Zsuzsanna Veres, György Török, Dániel Sándor Veres, Ildikó Horváth, Krisztián Szigeti, László Homolya, Attila Szijártó
Selective portal vein ligation (PVL) allows the two-stage surgical resection of primarily unresectable liver tumours by generating the atrophy and hypertrophy of portally ligated (LL) and non-ligated lobes (NLL), respectively. To evaluate critically important underlying functional alterations, present study characterised in vitro and vivo liver function in male Wistar rats (n = 106; 210-250 g) before, and 24/48/72/168/336 h after PVL. Lobe weights and volumes by magnetic resonance imaging confirmed the atrophy-hypertrophy complex...
December 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29259252/image-guided-fluorescence-endomicroscopy-from-macro-to-micro-imaging-of-radiation-induced-pulmonary-fibrosis
#4
Jessica R Perez, Norma Ybarra, Frederic Chagnon, Monica Serban, Gabriel Pare, Olivier Lesur, Jan Seuntjens, Issam El Naqa
Radiation-induced pulmonary fibrosis (RIPF) is a debilitating side effect of radiation therapy (RT) of several cancers including lung and breast cancers. Current clinical methods to assess and monitor RIPF involve diagnostic computed tomography (CT) imaging, which is restricted to anatomical macroscopic changes. Confocal laser endomicroscopy (CLE) or fluorescence endomicroscopy (FE) in combination with a fibrosis-targeted fluorescent probe allows to visualize RIPF in real-time at the microscopic level. However, a major limitation of FE imaging is the lack of anatomical localization of the endomicroscope within the lung...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29251271/can-endoscopic-ultrasound-guided-needle-based-confocal-laser-endomicroscopy-replace-fine-needle-aspiration-for-pancreatic-and-mediastinal-diseases
#5
REVIEW
Jintao Guo, Manoop S Bhutani, Marc Giovannini, Zhaoshen Li, Zhendong Jin, Aiming Yang, Guoqiang Xu, Guiqi Wang, Siyu Sun
New applications of confocal laser endomicroscopy (CLE) have been developed, such as needle-based CLE (nCLE) for pancreatic masses, pancreatic cystic tumors, and lymph nodes. nCLE is feasible during endoscopic ultrasound (EUS) examination, and preliminary results are very encouraging and suggest this technology may be used in future as a useful adjunct in cases of inconclusive EUS-guided fine-needle aspiration. The aim of this paper is to give an update in this new technology and to define its place in the diagnosis of pancreatic masses and mediastinal diseases...
November 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/29186737/the-role-of-confocal-laser-endomicroscopy-in-assessing-mucosal-healing-in-patients-with-ulcerative-proctitis
#6
Cristian Gheorghe, Gabriel Becheanu, Razvan Iacob, Bogdan Cotruta, Anca Dimitriu
No abstract text is available yet for this article.
December 2017: Endoscopy
https://www.readbyqxmd.com/read/29183138/-experimental-model-for-cardiogenic-shock-with-pericardial-tamponade
#7
Gábor Bari, Szilárd Szűcs, Dániel Érces, Melinda Ugocsai, Noémi Bozsó, Dóra Balog, Mihály Boros, Gabriella Varga
INTRODUCTION: Pericardial tamponade (PT) is a life-threatening condition, with low cardiac output. The hemodynamic consequences of PT can severely affect the circulation of all tissues, including the microcirculation of the kidneys and the intestinal mucosa. Our aim was to develop a hemodynamically stable and controllable large animal model of PT to study the consequences of cardiogenic shock. METHODS: Two groups of anesthetized vietnamese minipigs (n = 6, both groups) were used...
December 2017: Magyar Sebészet
https://www.readbyqxmd.com/read/29159273/a-health-economic-evaluation-of-needle-based-confocal-laser-endomicroscopy-for-the-diagnosis-of-pancreatic-cysts
#8
Claude Le Pen, Laurent Palazzo, Bertrand Napoléon
Background and study aims:  The low sensitivity of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), especially for the diagnosis of serous cystadenomas (SCAs), can be associated with diagnostic uncertainty that can regularly lead to unnecessary surgical procedures. Needle-based confocal laser endomicroscopy (nCLE) used with EUS-FNA improves diagnostic accuracy, helping to reduce unnecessary surgery and patient follow-up. This study was conducted to evaluate the economic benefit of EUS-FNA + nCLE...
October 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29110046/-supplementary-optical-techniques-for-the-detection-of-nonmuscle-invasive-bladder-cancer
#9
REVIEW
S Aeishen, Y Dawood, S Papadoukakis, M Horstmann
White light cystoscopy (WL) is the gold standard for the detection of bladder cancer. It can be performed using a rigid or flexible urethrocystoscope. With the more recent introduction of high definition (HD) techniques, WL cystoscopy has been decisively improved. Supplementary optical techniques are also used to improve the detection of bladder cancer. Among these are photodynamic diagnosis (PDD), narrow-band imaging (NBI), S‑technologies of IMAGE1 S, optical coherence tomography (OCT), confocal laser endomicroscopy (CLE), and Raman spectroscopy...
November 6, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29108979/prediction-of-clinical-outcomes-in-crohn-s-disease-by-using-confocal-laser-endomicroscopy-results-from-a-prospective-multicenter-study
#10
Gian Eugenio Tontini, Jonas Mudter, Michael Vieth, Claudia Günther, Valentina Milani, Raja Atreya, Timo Rath, Andreas Nägel, Giorgia Hatem, Giacomo Carlo Sturniolo, Maurizio Vecchi, Markus F Neurath, Peter R Galle, Andrea Buda, Helmut Neumann
BACKGROUND & AIMS: Assessment of prognostic factors in Crohn's disease (CD) patients is of pivotal importance for early intervention and "treat-to-target" strategies. Confocal Laser Endomicroscopy (CLE) enables on demand in vivo characterization of mucosal inflammatory and architectural changes during endoscopy. We prospectively assessed the value of CLE for prediction of clinical outcome parameters in CD. METHODS: Consecutive patients with CD undergoing colonoscopy were included in a multicentre study...
November 3, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29104910/implementation-of-real-time-probe-based-confocal-laser-endomicroscopy-pcle-for-differentiation-of-colorectal-polyps-during-routine-colonoscopy
#11
Tim D G Belderbos, Martijn G H van Oijen, Leon M G Moons, Peter D Siersema
Background and aims:  Probe-based confocal laser endomicroscopy (pCLE) is used to differentiate between neoplastic and non-neoplastic colorectal polyps during colonoscopy. We aimed to assess the accuracy of two endoscopists starting to use real-time pCLE for differentiation of colorectal polyps and to determine the negative predictive value (NPV) for neoplasia in polyps ≤ 5 mm. Methods:  Patients undergoing colonoscopy in a tertiary hospital were included in this prospective trial...
November 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29067583/feasibility-of-real-time-intestinal-bloodstream-evaluation-using-probe-based-confocal-laser-endomicroscopy-in-a-porcine-intestinal-ischemia-model
#12
Tsuyoshi Takahashi, Rie Nakatsuka, Hisashi Hara, Shigeyoshi Higashi, Kouji Tanaka, Yasuhiro Miyazaki, Tomoki Makino, Yukinori Kurokawa, Makoto Yamasaki, Shuji Takiguchi, Masaki Mori, Yuichiro Doki, Kiyokazu Nakajima
BACKGROUND: Intestinal ischemia can lead to fatal complications if left unrecognized during surgery. The current techniques of intraoperative microvascular assessment remain subjective. Probe-based confocal laser endomicroscopy (pCLE) has the potential to objectively evaluate microvascular blood flow in real-time setting. The present study evaluated the technical feasibility of real-time intestinal bloodstream evaluation using pCLE in a porcine intestinal ischemia model. METHODS: Seven pigs were used...
October 24, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29034764/indeterminate-biliary-strictures-a-simplified-approach
#13
Chencheng Xie, Khalil Aloreidi, Bhavesh Patel, Timothy Ridgway, Thavam Thambi-Pillai, Gary Timmerman, Adeel Khan, Muslim Atiq
Pre-operative evaluation of biliary strictures remains challenging. The dilemma that exists is how to balance the risk of failing to detect malignancy and the potential morbidity caused by unnecessary surgery in patients with benign etiologies. With emerging novel diagnostic modalities, this study aims to assess the efficacy of diagnostic techniques and facilitate a clinical approach to indeterminate biliary strictures. Areas covered: Conventional imaging modalities are crucial in identifying the location of a stricture and are helpful for choosing further diagnostic modalities...
February 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29028105/value-of-confocal-laser-endomicroscopy-in-the-diagnosis-of-vocal-cord-lesions
#14
M Goncalves, H Iro, A Dittberner, A Agaimy, C Bohr
OBJECTIVE: The aim of this study was to assess the reliability and limitations of confocal laser endomicroscopy (CLE) for diagnosing lesions of the vocal cords and differentiating malignant from non-malignant lesions. PATIENTS AND METHODS: During microlaryngoscopy, the vocal cords were scanned by probe-based CLE (pCLE: a GastroFlex probe with the Cellvizio® laser system, Mauna Technologies, Paris, France). The video recordings were analyzed and compared with the histological results...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29017290/role-of-advanced-endoscopic-imaging-techniques-in-the-management-of-inflammatory-bowel-disease
#15
REVIEW
Eun Soo Kim
Endoscopy plays a crucial role in the management of inflammatory bowel disease (IBD) in terms of diagnosis, monitoring of mucosal status, and surveillance of colitis-associated neoplasia. Mucosal healing evaluated by endoscopy has been recognized as the target of treatment in the era of powerful biologics therapy. The optimal modality for identifying dysplasia in IBD has yet to be well defined. Increasing progress has recently been made in endoscopic technologies to more accurately assess mucosal inflammation and more effectively detect dysplasia...
September 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28938608/use-of-confocal-laser-endomicroscopy-with-a-fluorescently-labeled-fatty-acid-to-diagnose-colorectal-neoplasms
#16
Feihong Deng, Yuan Fang, Zhiyong Shen, Wei Gong, Tao Liu, Jing Wen, Wanling Zhang, Xianjun Zhu, Hui Zhong, Tong Wang, Fachao Zhi, Biao Nie
Endoscopic treatment for early colorectal cancer closely correlates with patient prognosis. However, endoscopic differentiation between carcinomas and non-neoplastic lesions remains difficult. Here, we topically stained colorectal neoplasms with a fatty acid analogue (BODIPY-FA) and quantified the fluorescent signals using confocal laser endomicroscopy (CLE) and fluorescence microscopy. We also analyzed protein expression in colorectal cancer tissues. We found that expression of fatty acid synthase was elevated, while the expression of fatty acid transporters was reduced in colorectal cancer...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28932568/needle-based-confocal-laser-endomicroscopy-in-the-diagnosis-of-peripheral-pulmonary-nodule-a-preliminary-report
#17
Zhuquan Su, Changhao Zhong, Shiyue Li, Xiaobo Chen, Yu Chen, Chunli Tang
Lung cancer is one of the most fatal cancers in the world. To early distinguish benign and malignant pulmonary nodule is critical for disease prognosis. Confocal laser endomicroscopy (CLE) can be used to explore bronchus mucous membrane, alveolar elastic fiber structures and microvessels, and could be helpful for the diagnostic imaging and for the localization guidance. In this report, we presented two cases of peripheral pulmonary nodule. Under the guidance of X-ray and endobronchial ultrasound, needle-based confocal laser endomicroscopy (nCLE) could directly approach the peripheral pulmonary nodule via an exploratory puncture needle...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28931888/automatic-classification-of-cancerous-tissue-in-laserendomicroscopy-images-of-the-oral-cavity-using-deep-learning
#18
Marc Aubreville, Christian Knipfer, Nicolai Oetter, Christian Jaremenko, Erik Rodner, Joachim Denzler, Christopher Bohr, Helmut Neumann, Florian Stelzle, Andreas Maier
Oral Squamous Cell Carcinoma (OSCC) is a common type of cancer of the oral epithelium. Despite their high impact on mortality, sufficient screening methods for early diagnosis of OSCC often lack accuracy and thus OSCCs are mostly diagnosed at a late stage. Early detection and accurate outline estimation of OSCCs would lead to a better curative outcome and a reduction in recurrence rates after surgical treatment. Confocal Laser Endomicroscopy (CLE) records sub-surface micro-anatomical images for in vivo cell structure analysis...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28929643/demons-registration-for-in-vivo-and-deformable-laser-scanning-confocal-endomicroscopy
#19
Wei-Ming Chiew, Feng Lin, Hock Soon Seah
A critical effect found in noninvasive in vivo endomicroscopic imaging modalities is image distortions due to sporadic movement exhibited by living organisms. In three-dimensional confocal imaging, this effect results in a dataset that is tilted across deeper slices. Apart from that, the sequential flow of the imaging-processing pipeline restricts real-time adjustments due to the unavailability of information obtainable only from subsequent stages. To solve these problems, we propose an approach to render Demons-registered datasets as they are being captured, focusing on the coupling between registration and visualization...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28922432/identifying-a-mucinous-neoplasm-utilizing-confocal-laser-endomicroscopy-branch-duct-gastric-type-intraductal-papillary-mucinous-neoplasm
#20
Amrit K Kamboj, Rohan M Modi, Darwin L Conwell, Somashekar G Krishna
No abstract text is available yet for this article.
September 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
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