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Confocal laser endomicroscopy

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https://www.readbyqxmd.com/read/29732957/prospective-trial-on-probe-based-confocal-laser-endomicroscopy-for-the-identification-of-the-distal-limit-in-rectal-adenocarcinoma
#1
Arthur R Wijsmuller, Jean-Pierre Ghnassia, Sharmini Varatharajah, Mickael Schaeffer, Joel Leroy, Jacques Marescaux, Mihaela Ignat, Didier Mutter
BACKGROUND: Intraoperative decision of the level of distal resection in rectal cancer is often imprecise, based exclusively on digital examination and pretherapeutic imaging. DESIGN: Prospective, single institution, nonrandomized trial ( ClinicalTrial.gov identification no. NCT01887509) to evaluate the contribution of probe-based confocal laser endomicroscopy (pCLE) to establish the optimal resection margin of rectal adenocarcinoma. The primary outcome was the concordance in the identification of lower tumor margins between pCLE and histopathology...
May 1, 2018: Surgical Innovation
https://www.readbyqxmd.com/read/29700599/pilot-study-on-probe-based-confocal-laser-endomicroscopy-for-colorectal-neoplasms-an-initial-experience-in-japan
#2
Seiichiro Abe, Yutaka Saito, Yasuhiro Oono, Yusaku Tanaka, Taku Sakamoto, Masayoshi Yamada, Takeshi Nakajima, Takahisa Matsuda, Hiroaki Ikematsu, Tomonori Yano, Shigeki Sekine, Motohiro Kojima, Hidetsugu Yamagishi, Hiroyuki Kato
BACKGROUND: The aim of this pilot study is to investigate the diagnostic yield of probe-based confocal laser endomicroscopy (pCLE) in the evaluation of depth of invasion in colorectal lesions. METHODS: Patients with colorectal lesions eligible for either endoscopic treatment or surgery were enrolled in the study. Tumor's depth of invasion was classified as mucosal or slight submucosal (M-SM1) and deep submucosal invasion or deeper (SM2 or deeper). White light endoscopy (WLE), magnifying narrow band imaging (M-NBI), and magnifying chromoendoscopy (M-CE) were used to assess colorectal lesions, and pCLE was used to identify tumor's features related to SM2 or deeper...
April 26, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29687176/effective-deep-learning-training-for-single-image-super-resolution-in-endomicroscopy-exploiting-video-registration-based-reconstruction
#3
Daniele Ravì, Agnieszka Barbara Szczotka, Dzhoshkun Ismail Shakir, Stephen P Pereira, Tom Vercauteren
PURPOSE: Probe-based confocal laser endomicroscopy (pCLE) is a recent imaging modality that allows performing in vivo optical biopsies. The design of pCLE hardware, and its reliance on an optical fibre bundle, fundamentally limits the image quality with a few tens of thousands fibres, each acting as the equivalent of a single-pixel detector, assembled into a single fibre bundle. Video registration techniques can be used to estimate high-resolution (HR) images by exploiting the temporal information contained in a sequence of low-resolution (LR) images...
April 23, 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29673821/diagnostic-accuracy-of-a-confocal-laser-endomicroscope-for-in-vivo-differentiation-between-normal-and-tumor-tissue-during-fluorescein-guided-glioma-resection-laboratory-investigation
#4
Evgenii Belykh, Eric J Miller, Arpan A Patel, Mohammedhassan Izady Yazdanabadi, Nikolay L Martirosyan, Kaan Yağmurlu, Baran Bozkurt, Vadim A Byvaltsev, Jennifer M Eschbacher, Peter Nakaji, Mark C Preul
OBJECTIVE: Glioma resection with fluorescein sodium (FNa) guidance has a potential drawback of nonspecific leakage of FNa from non-tumor areas with a compromised blood-brain barrier. We investigated the diagnostic accuracy of in vivo confocal laser endomicroscopy (CLE) after FNa administration to differentiate normal brain, injured normal brain, and tumor brain tissue in an animal glioma model. METHODS: GL261-Luc2 gliomas in C57BL/6 mice were used as a brain tumor model...
April 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29667626/eus-fna-in-cystic-pancreatic-lesions-where-are-we-now-and-where-are-we-headed-in-the-future
#5
REVIEW
Jose Lariño-Noia, Julio Iglesias-Garcia, Daniel de la Iglesia-Garcia, J Enrique Dominguez-Muñoz
EUS-FNA is often performed in the evaluation of Cystic Pancreatic Lesions (CPL) for a better preoperative characterization. The objective is to identify premalignant lesions as Mucinous Cystic Neoplasms, and/or a malignant transformation of them (adenocarcinoma). The role of cytological evaluation in this setting is discouraging and intracystic markers analysis, mainly CEA, lacks of a good specificity for the detection of mucinous neoplasms. New devices and approaches have emerged to overcome these problems as the cytology brush (Echobrush), the small mini-biopsy foceps, the cystoscopy and the needle Confocal LASER Endomicroscopy (nCLE), showing in some studies good rates of accuracy for distinguishing among mucinosus and non-mucinous neoplasms...
March 2018: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/29662543/optical-improvements-in-the-diagnosis-of-bladder-cancer-implications-for-clinical-practice
#6
REVIEW
Tina Schubert, Steffen Rausch, Omar Fahmy, Georgios Gakis, Arnulf Stenzl
Background: For over 100 years white-light cystoscopy has remained the gold-standard technique for the detection of bladder cancer (BCa). Some limitations in the detection of flat lesions (CIS), the differentiation between inflammation and malignancy, the inaccurate determination of the tumor margin status as well as the tumor depth, have led to a variety of technological improvements. The aim of this review is to evaluate the impact of these improvements in the diagnosis of BCa and their effectiveness in clinical practice...
November 2017: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/29607393/accuracy-of-probe-based-confocal-laser-endomicroscopy-pcle-compared-to-random-biopsies-during-endoscopic-surveillance-of-barrett-s-esophagus
#7
Tilak Shah, Robert Lippman, Divyanshoo Kohli, Pritesh Mutha, Sanjeev Solomon, Alvin Zfass
Background:  For surveillance of Barrett's esophagus (BE), the current standard of random 4-quadrant biopsies misses 10 - 50 % of esophageal neoplasms, and does not permit real-time decision-making. Probe-based confocal laser endomicroscopy (pCLE) permits real-time in vivo histologic assessment of esophageal mucosa during upper endoscopy. Prospective studies comparing the accuracy of pCLE to 4-quadrant biopsies in routine clinical practice are lacking. Methods:  Consecutive patients with BE underwent high definition white light and narrow-band imaging followed by pCLE and targeted biopsy or mucosal resection...
April 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29588511/structure-and-distribution-of-an-unrecognized-interstitium-in-human-tissues
#8
Petros C Benias, Rebecca G Wells, Bridget Sackey-Aboagye, Heather Klavan, Jason Reidy, Darren Buonocore, Markus Miranda, Susan Kornacki, Michael Wayne, David L Carr-Locke, Neil D Theise
Confocal laser endomicroscopy (pCLE) provides real-time histologic imaging of human tissues at a depth of 60-70 μm during endoscopy. pCLE of the extrahepatic bile duct after fluorescein injection demonstrated a reticular pattern within fluorescein-filled sinuses that had no known anatomical correlate. Freezing biopsy tissue before fixation preserved the anatomy of this structure, demonstrating that it is part of the submucosa and a previously unappreciated fluid-filled interstitial space, draining to lymph nodes and supported by a complex network of thick collagen bundles...
March 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29563760/colonic-lesion-characterization-in-inflammatory-bowel-disease-a-systematic-review-and-meta-analysis
#9
Richard Lord, Nicholas E Burr, Noor Mohammed, Venkataraman Subramanian
AIM: To perform a systematic review and meta-analysis for the diagnostic accuracy of in vivo lesion characterization in colonic inflammatory bowel disease (IBD), using optical imaging techniques, including virtual chromoendoscopy (VCE), dye-based chromoendoscopy (DBC), magnification endoscopy and confocal laser endomicroscopy (CLE). METHODS: We searched Medline, Embase and the Cochrane library. We performed a bivariate meta-analysis to calculate the pooled estimate sensitivities, specificities, positive and negative likelihood ratios (+LHR, -LHR), diagnostic odds ratios (DOR), and area under the SROC curve (AUSROC) for each technology group...
March 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29543078/comparison-of-diagnostic-efficacy-between-cle-tissue-sampling-and-cle-combined-with-tissue-sampling-for-undetermined-pancreaticobiliary-strictures-a-meta-analysis
#10
Ya-Dong Gao, Ya-Wei Qu, Hai-Feng Liu
OBJECTIVE: The accurate diagnosis of undetermined pancreaticobiliary strictures remains challenging. Current ERCP-guided tissue sampling methods are of low sensitivity. Confocal laser endomicroscopy (CLE) is a new procedure and allows real optical biopsies that may improve the diagnosis of undetermined pancreaticobiliary strictures. The aim of this meta-analysis was to determine the diagnostic yield of CLE, tissue sampling, and CLE combined with tissue sampling for undetermined pancreaticobiliary strictures...
March 15, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29503871/probe-based-confocal-laser-endomicroscopy-using-acrinol-as-a-novel-dye-can-be-used-to-observe-cancer-nuclei-of-bladder-carcinoma-in-situ
#11
Yoshio Naya, Natsuki Takaha, Takako Okubo, Koji Shiota, Issei Hayashi, Masaru Mori, Seiki Date, Tsuneharu Miki, Osamu Ukimura
Background: Cystoscopy using white light is a standard procedure for diagnosing bladder cancer; however, white light can result in missed lesions that are present, but not visible, such as in cases of carcinoma in situ (CIS). In this case report, we describe observing the nuclei of urothelial carcinoma cells in situ that were not visible with cystoscopy under white light using probe-based confocal laser endomicroscopy (pCLE) with acrinol and fluorescein during transurethral resection of a bladder tumor (TURBT)...
2018: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/29451364/prevalence-of-celiac-disease-in-adult-chinese-patients-with-diarrhea-predominant-irritable-bowel-syndrome-a-prospective-controlled-cohort-study
#12
Guan Jun Kou, Jing Guo, Xiu Li Zuo, Chang Qing Li, Chao Liu, Rui Ji, Han Liu, Xiao Wang, Yan Qing Li
OBJECTIVE: Celiac disease is a chronic inflammatory enteropathy with a symptom spectrum similar to that of irritable bowel syndrome (IBS). It is a common but largely undiagnosed condition in the Western countries. However, it is extremely rare among Chinese individuals, and few studies have investigated its prevalence in China. The aim was to determine the prevalence of celiac disease in patients with IBS who were diagnosed using the Rome III criteria in a single center of northern China...
March 2018: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29415874/confocal-laser-endomicroscopy-for-the-diagnosis-of-urothelial-carcinoma-in-the-bladder-and-the-upper-urinary-tract-protocols-for-two-prospective-explorative-studies
#13
Esmee Iml Liem, Jan Erik Freund, Joyce Baard, D Martijn de Bruin, M Pilar Laguna Pes, C Dilara Savci-Heijink, Ton G van Leeuwen, Theo M de Reijke, Jean Jmch de la Rosette
BACKGROUND: Visual confirmation of a suspicious lesion in the urinary tract is a major corner stone in diagnosing urothelial carcinoma. However, during cystoscopy (for bladder tumors) and ureterorenoscopy (for tumors of the upper urinary tract) no real-time histopathologic information can be obtained. Confocal laser endomicroscopy (CLE) is an optical imaging technique that allows for in vivo high-resolution imaging and may allow real-time tumor grading of urothelial lesions. OBJECTIVE: The primary objective of both studies is to develop descriptive criteria for in vivo CLE images of urothelial carcinoma (low-grade, high-grade, carcinoma in situ) and normal urothelium by comparing CLE images with corresponding histopathology...
February 7, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29398900/evaluation-of-new-technologies-in-gastrointestinal-endoscopy
#14
REVIEW
Murat Akarsu, Cevher Akarsu
Gastrointestinal (GI) tumors are the most commonly diagnosed cancers worldwide and the second leading cause of cancer-related death. Endoscopy is the gold standard for diagnosis of GI cancers. Early diagnosis of GI tumors by endoscopy at the precancerous or early stage may decrease the prevalence and mortality rate of GI cancers. The preventive role of endoscopic interventions and the limitations of conventional white-light endoscopy have given rise to myriad innovations. Chromoendoscopy with dye injection can be used to detect lesions at an early stage...
January 2018: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/29375735/confocal-endomicroscopy-and-cyst-fluid-molecular-analysis-comprehensive-evaluation-of-pancreatic-cysts
#15
REVIEW
Feng Li, Ahmad Malli, Zobeida Cruz-Monserrate, Darwin L Conwell, Somashekar G Krishna
Increases in the quality as well as utilization of cross-sectional imaging have led to rising diagnoses of pancreatic cystic lesions (PCL). Accurate presurgical diagnosis enables appropriate triage of PCLs. Unfortunately, current diagnostic approaches have suboptimal accuracy and may lead to unnecessary surgical resections or missed diagnoses of advanced neoplasia. Additionally, early detection represents an opportunity for intervention to prevent the progression to pancreatic adenocarcinoma. Our aim for this review is to systematically review the current literature on confocal endomicroscopy and molecular biomarkers in the evaluation of PCLs...
January 16, 2018: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29344572/expert-led-didactic-versus-self-directed-audiovisual-training-of-confocal-laser-endomicroscopy-in-evaluation-of-mucosal-barrier-defects
#16
Roy Huynh, Matthew Ip, Jeff Chang, Craig Haifer, Rupert W Leong
Background and study aims:  Confocal laser endomicroscopy (CLE) allows mucosal barrier defects along the intestinal epithelium to be visualized in vivo during endoscopy. Training in CLE interpretation can be achieved didactically or through self-directed learning. This study aimed to compare the effectiveness of expert-led didactic with self-directed audiovisual teaching for training inexperienced analysts on how to recognize mucosal barrier defects on endoscope-based CLE (eCLE). Materials and methods:  This randomized controlled study involved trainee analysts who were taught how to recognize mucosal barrier defects on eCLE either didactically or through an audiovisual clip...
January 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29344564/endoscopic-ultrasound-guided-needle-based-confocal-laser-endomicroscopy-in-solid-pancreatic-masses-a-prospective-validation-study
#17
John Gásdal Karstensen, Tatiana Cârţână, Codruţa Constantinescu, Silviu Dumitrașcu, Bojan Kovacevic, Pia Klausen, Hazem Hassan, Tobias Wirenfeldt Klausen, Helga Bertani, Manoop S Bhutani, Adrian Săftoiu, Peter Vilmann
Background and study aims:  Endoscopic ultrasound fine-needle aspiration (EUS-FNA) is a keystone in diagnosing and staging of pancreatic masses. Recently, a microfiber that can pass through a 19-gauge needle has been introduced for confocal laser endomicroscopy (nCLE). The aims of this study were to evaluate the diagnostic value and the reproducibility of nCLE criteria for solid malignant lesions. Patients and methods:  This prospective dual-center study included patients with pancreatic masses suspicious of malignancy referred for EUS-FNA...
January 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29340932/robotic-scanning-device-for-intraoperative-thyroid-gland-endomicroscopy
#18
Haibo Wang, Shuxin Wang, Jinhua Li, Siyang Zuo
Probe-based confocal laser endomicroscopy has a high potential to be a promising tool that can provide intraoperative high-resolution in vivo morphological imaging at cellular and subcellular levels for thyroidectomy, and allow real-time assessment of tumor margins. However, the typical images acquired with this technique cover a very small area limited by the field of view of the probe, accompanied by tissue deformation and inconsistent probe-tissue contact when operated manually. In this paper, a novel compact robotic device for large area scanning has been developed...
January 16, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29286374/optical-screening-of-novel-bacteria-specific-probes-on-ex-vivo-human-lung-tissue-by-confocal-laser-endomicroscopy
#19
Bethany Mills, Ahsan R Akram, Emma Scholefield, Mark Bradley, Kevin Dhaliwal
Improving the speed and accuracy of bacterial detection is important for patient stratification and to ensure the appropriate use of antimicrobials. To achieve this goal, the development of diagnostic techniques to recognize bacterial presence in real-time at the point-of-care is required. Optical imaging for direct identification of bacteria within the host is an attractive approach. Several attempts at chemical probe design and validation have been investigated, however none have yet been successfully translated into the clinic...
November 29, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29277482/comparison-of-narrow-band-imaging-and-confocal-laser-endomicroscopy-for-the-detection-of-neoplasia-in-barrett-s-esophagus-a-meta-analysis
#20
Yi-Quan Xiong, Shu-Juan Ma, Hao-Yue Hu, Jing Ge, Li-Zhi Zhou, Shu-Ting Huo, Min Qiu, Qing Chen
AIMS: Barrett's esophagus (BE) predisposes to the development of esophageal neoplasia, including high-grade dysplasia (HGD) and esophageal adenocarcinoma (EAC). A systematic literature review and meta-analysis were performed to assess the accuracy of within-patient comparisons of narrow band imaging (NBI) and confocal laser endomicroscopy (CLE) for diagnosis of HGD/EAC in patients with BE. METHODS: The following databases were examined up to April 2016 without language restriction: PubMed, Embase, Medline, Web of Science and the Cochrane Library...
February 2018: Clinics and Research in Hepatology and Gastroenterology
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