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Confocal laser endomicroscopy

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https://www.readbyqxmd.com/read/27904863/recent-updates-in-the-endoscopic-diagnosis-of-barrett-s-oesophagus
#1
REVIEW
Neel Sharma, Khek Yu Ho
BACKGROUND: Barrett's oesophagus (BO) is a premalignant condition associated with the development of oesophageal adenocarcinoma (OAC). Despite the low risk of progression per annum, OAC is associated with significant morbidity and mortality, with an estimated 5-year survival of 10%. Furthermore, the incidence of OAC continues to rise globally. Therefore, it is imperative to detect the premalignant phase of BO and follow up such patients accordingly. SUMMARY: The mainstay diagnosis of BO is endoscopy and biopsy sampling...
October 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27888870/latest-advances-in-pancreatic-tumours
#2
José Lariño Noia
Pancreatic cancer continues to have a bleak prognosis. Hardly any therapeutic advances have been made in the last few years and consequently most efforts have focused on preventing its development and on diagnosing precursor lesions. In this regard, the use of statins as a preventive factor and the implementation of screening programmes in high-risk patients are gaining ground. In the field of treatment, there is greater focus on the role of neoadjuvant therapy in pancreatic cancer and on a multimodal approach to the disease, with few advances in effective novel therapies...
September 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27866871/endoscopic-ultrasound-of-pancreatic-tumors
#3
M Wangermez
Computed tomography (CT) and endoscopic ultrasound (EUS) are the two most effective techniques for the assessment of pancreatic cancers. CT has revolutionized the field of tumor imaging in pancreatic cancer and is now a well-established imaging technique for diagnosis and staging. However, EUS still plays an important role in several situations, especially when the diagnosis is uncertain or when histopathological confirmation of the lesion is needed. Similarly, regarding cystic lesions, magnetic resonance imaging and CT have very good performances but are often inadequate because the diagnosis can be difficult to establish, while the consequences for the patient are major...
November 17, 2016: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/27862291/probe-based-confocal-laser-endomicroscopy-in-the-margin-delineation-of-early-gastric-cancer-for-endoscopic-submucosal-dissection
#4
Jun Chul Park, Yehyun Park, Hyun Ki Kim, Jeong-Hyeon Jo, Chan Hyuk Park, Eun Hye Kim, Da Hyun Jung, Hyunsoo Chung, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee
BACKGROUND AND AIM: We evaluated pCLE in the margin delineation of early gastric cancer (EGC) for endoscopic submucosal dissection (ESD) in comparison with white-light imaging with chromoendoscopy (CE). METHODS: We conducted a prospective, randomized controlled study from November 2013 to October 2014 in a tertiary referral hospital. A total of 101 patients scheduled for ESD due to differentiated EGC were randomized into pCLE and CE groups (pCLE 51, CE 50). Markings were made by electrocautery at the proximal and distal tumor margins, as determined by either pCLE or CE...
November 9, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27853737/validation-of-diagnostic-characteristics-of-needle-based-confocal-laser-endomicroscopy-in-differentiation-of-pancreatic-cystic-lesions
#5
Somashekar G Krishna, Benjamin Swanson, Phil A Hart, Samer El-Dika, Jon P Walker, Sean T McCarthy, Ahmad Malli, Zarine K Shah, Darwin L Conwell
: Background and aims: Endoscopic ultrasound (EUS)-guided needle-based Confocal Laser Endomicroscopy (nCLE) characteristics of pancreatic cystic lesions (PCLs) have been identified in studies where the gold standard surgical histopathology was available in a minority of patients. There are diverging reports of interobserver agreement (IOA) and paucity of intraobserver reliability (IOR). Thus, we sought to validate current EUS-nCLE criteria of PCLs in a larger consecutive series of surgical patients...
November 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27813096/real-time-confocal-laser-endomicroscopic-evaluation-of-primary-liver-cancer-based-on-human-liver-autofluorescence
#6
Harufumi Maki, Yoshikuni Kawaguchi, Junichi Arita, Nobuhisa Akamatsu, Junichi Kaneko, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Yasushi Harihara, Norihiro Kokudo
BACKGROUND: Confocal laser endomicroscopy (CLE) is available for real-time microscopic examination. This study aims to evaluate the usefulness of intraoperative CLE examination as a modality to evaluate surgical margins in surgery for primary liver cancer. METHODS: A probe-based CLE system (Cellvizio 100, Mauna Kea Technologies, Paris, France) was used. The subjects comprised seven specimens obtained from six patients with primary liver cancer in November 2015. The probe was manually attached to the surfaces of specimens, and images were collected without external fluorophores...
November 4, 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27808042/evaluation-of-confocal-laser-endomicroscopy-for-assessment-and-monitoring-of-therapeutic-response-in-patients-with-inflammatory-bowel-disease
#7
John Gásdal Karstensen
BACKGROUND: Crohn's disease (CD) and ulcerative colitis (UC) have been associated with altered intestinal barrier function. Moreover, it has been proposed that a defective barrier function is related to risk of relapse in patients with quiescent CD. Fluorescein-aided confocal laser endomicroscopy (CLE) is a novel endoscopic method, which enables real-time in vivo microscopy. Hence, the intestinal barrier function can be assessed as part of endoscopic evaluation of patients with inflammatory bowel disease (IBD) by measuring microerosions and fluorescein leakage into the intestinal lumen...
November 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27803901/the-role-of-intraductal-ultrasonography-in-pancreatobiliary-diseases
#8
REVIEW
Bo Sun, Bing Hu
Intraductal ultrasonography (IDUS) provides real-time, cross-sectional imaging of pancreatobiliary ducts and surrounding structures during endoscopic retrograde cholangiopancreatography using a high-frequency ultrasound (US) transducer. Hence, IDUS has been considered a sensitive tool in the evaluation of suspicious choledocholithiasis and neoplasms, to help distinguish between benign and malignant bile duct strictures or wall thickness, and to assess tumor extension and invasion depth. With the rapid development and enriched choices of sensitive diagnostic modalities include but are not limited to endoscopic US, peroral cholangioscopy, and confocal laser endomicroscopy, it is needed to systematically assess the role of IDUS in the investigation of pancreatobiliary diseases...
September 2016: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/27748256/presurgical-mapping-of-basal-cell-carcinoma-or-squamous-cell-carcinoma-by-confocal-laser-endomicroscopy-compared-to-traditional-micrographic-surgery-a-single-centre-prospective-feasibility-study
#9
Alexandra Schulz, Samira Daali, Mehreen Javed, Paul Christian Fuchs, Michael Brockmann, Alhadi Igressa, Patra Charalampaki
BACKGROUND: At present, no ideal diagnostic tools exist in the market to excise cancer tissue with the required safety margins and to achieve optimal aesthetic results using tissue-conserving techniques. OBJECTIVES: In this prospective study, confocal laser endomicroscopy (CLE) and the traditional gold standard of magnifying glasses (MG) were compared regarding the boundaries of in vivo basal cell carcinoma and squamous cell carcinoma. MATERIALS & METHODS: Tumour diameters defined by both methods were measured and compared with those determined by histopathological examination...
October 17, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27739457/multimodal-imaging-of-a-humanized-orthotopic-model-of-hepatocellular-carcinoma-in-immunodeficient-mice
#10
Tao Wu, Emilie Heuillard, Véronique Lindner, Ghina Bou About, Mihaela Ignat, Jean-Philippe Dillenseger, Nicolas Anton, Eugénie Dalimier, Francine Gossé, Gael Fouré, Franck Blindauer, Céline Giraudeau, Hussein El-Saghire, Mourad Bouhadjar, Cynthia Calligaro, Tania Sorg, Philippe Choquet, Thierry Vandamme, Christophe Ferrand, Jacques Marescaux, Thomas F Baumert, Michele Diana, Patrick Pessaux, Eric Robinet
The development of multimodal strategies for the treatment of hepatocellular carcinoma requires tractable animal models allowing for advanced in vivo imaging. Here, we characterize an orthotopic hepatocellular carcinoma model based on the injection of luciferase-expressing human hepatoma Huh-7 (Huh-7-Luc) cells in immunodeficient mice. Luciferase allows for an easy repeated monitoring of tumor growth by in vivo bioluminescence. The intrahepatic injection was more efficient than intrasplenic or intraportal injection in terms of survival, rate of orthotopic engraftment, and easiness...
October 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27734273/past-and-current-trends-in-endoscopic-diagnosis-for-early-stage-gastric-cancer-in-japan
#11
Kazuki Sumiyama
Methodology for the diagnosis and staging of early gastric cancer (EGC) has improved in Japan since the development of the gastro-camera and determination of a definition of EGC. Imaging technology has been steadily evolving in the endoscopy field. Improvements in the resolution of standard endoscopy images used in screening and surveillance provide greater opportunities to find gastric cancer earlier. Image enhancement endoscopy (IEE), such as narrow band imaging (NBI), highlights mucosal structures and vascularity...
October 12, 2016: Gastric Cancer
https://www.readbyqxmd.com/read/27711949/advanced-endoscopic-imaging-european-society-of-gastrointestinal-endoscopy-esge-technology-review
#12
James E East, Jasper L Vleugels, Philip Roelandt, Pradeep Bhandari, Raf Bisschops, Evelien Dekker, Cesare Hassan, Gareth Horgan, Ralf Kiesslich, Gaius Longcroft-Wheaton, Ana Wilson, Jean-Marc Dumonceau
Background and aim: This technical review is an official statement of the European Society of Gastrointestinal Endoscopy (ESGE). It addresses the utilization of advanced endoscopic imaging in gastrointestinal (GI) endoscopy. Methods: This technical review is based on a systematic literature search to evaluate the evidence supporting the use of advanced endoscopic imaging throughout the GI tract. Technologies considered include narrowed-spectrum endoscopy (narrow band imaging [NBI]; flexible spectral imaging color enhancement [FICE]; i-Scan digital contrast [I-SCAN]), autofluorescence imaging (AFI), and confocal laser endomicroscopy (CLE)...
October 6, 2016: Endoscopy
https://www.readbyqxmd.com/read/27699107/dual-modality-endomicroscopy-with-co-registered-fluorescence-and-phase-contrast
#13
C Ba, M Palmiere, J Ritt, J Mertz
We describe a dual-modality laser scanning endomicroscope that provides simultaneous fluorescence contrast based on confocal laser endomicroscopy (CLE) and phase-gradient contrast based on scanning oblique back-scattering microscopy (sOBM). The probe consists of a 2.6mm-diameter micro-objective attached to a 30,000-core flexible fiber bundle. The dual contrasts are inherently co-registered, providing complementary information on labeled and un-labeled sample structure. Proof of principle demonstrations are presented with ex-vivo mouse colon tissue...
September 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27697445/diagnostic-accuracy-of-probe-based-confocal-laser-endomicroscopy-in-lugol-unstained-esophageal-superficial-lesions-of-patients-with-head-and-neck-cancer
#14
Adriana Vaz Safatle-Ribeiro, Elisa Ryoka Baba, Sheila Friedrich Faraj, Juliana Trazzi Rios, Marcelo Simas de Lima, Bruno Costa Martins, Sebastian Naschold Geiger, Caterina Pennacchi, Carla Gusman, Fábio Shiguehissa Kawaguti, Ricardo Sato Uemura, Evandro Sobroza de Melo, Ulysses Ribeiro Junior, Fauze Maluf-Filho
BACKGROUND AND AIMS: Surveillance programs of patients with head and neck cancer (HNC) detect synchronous or metachronous esophageal squamous cell carcinoma (ESCC) in up to 15% of the patients. Non-invasive probe-based confocal laser endomicroscopy (pCLE) technique may improve the diagnosis allowing acquisition of high-resolution in vivo images at the cellular and microvascular levels. The aim was to evaluate the accuracy of pCLE for the differential diagnosis of non-neoplastic and neoplastic Lugol-unstained esophageal lesions in patients with HNC...
September 30, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27696456/systematic-review-with-meta-analysis-endoscopic-retrograde-cholangiopancreatography-based-modalities-for-the-diagnosis-of-cholangiocarcinoma-in-primary-sclerosing-cholangitis
#15
REVIEW
B Njei, T R McCarty, S Varadarajulu, U Navaneethan
BACKGROUND: The accuracy of current endoscopic modalities for diagnosing cholangiocarcinoma in primary sclerosing cholangitis (PSC) is suboptimal. AIM: To evaluate the comparative effectiveness of endoscopic retrograde cholangiopancreatography (ERCP)-based modalities, independently or in combination, for the diagnosis of cholangiocarcinoma in patients with PSC-induced biliary strictures. METHODS: Searches of PubMed, EMBASE, Web of Science and the Cochrane Library databases were performed through December 2015...
December 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27681220/novel-insights-into-esophageal-diagnostic-procedures
#16
Edoardo Savarino, Andrea Ottonello, Salvatore Tolone, Ottavia Bartolo, Myong Ki Baeg, Farhood Farjah, Shiko Kuribayashi, Katerina P Shetler, Christian Lottrup, Ellen Stein
The 21st century offers new advances in diagnostic procedures and protocols in the management of esophageal diseases. This review highlights the most recent advances in esophageal diagnostic technologies, including clinical applications of novel endoscopic devices, such as ultrathin endoscopy and confocal laser endomicroscopy for diagnosis and management of Barrett's esophagus; novel parameters and protocols in high-resolution esophageal manometry for the identification and better classification of motility abnormalities; innovative connections between esophageal motility disorder diagnosis and detection of gastroesophageal reflux disease (GERD); impedance-pH testing for detecting the various GERD phenotypes; performance of distensibility testing for better pathophysiological knowledge of the esophagus and other gastrointestinal abnormalities; and a modern view of positron emission tomography scanning in metastatic disease detection in the era of accountability as a model for examining other new technologies...
September 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27669477/french-comment-on-article-endoscopic-ultrasound-guided-needle-based-confocal-laser-endomicroscopy-in-solid-pancreatic-masses
#17
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Endoscopy
https://www.readbyqxmd.com/read/27662497/diagnostic-accuracy-of-confocal-laser-endomicroscopy-for-the-characterization-of-liver-nodules
#18
Angelo Pierangelo, David Fuks, Pierre Validire, Ali Benali, Brice Gayet
OBJECTIVES: Probe-based confocal laser endomicroscopy (pCLE) is a promising new imaging technique enabling in-vivo analysis of tissues at the cellular level, in real time. The aim of the present study was to prospectively evaluate the feasibility and accuracy of indocyanine green-aided pCLE for the diagnosis of malignant liver nodules. PATIENTS AND METHODS: From October 2014 to July 2015, liver specimens from 30 consecutive patients were analyzed ex vivo using pCLE directly after resection, with indocyanine green as contrast agent...
January 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27643918/intraoperative-probe-based-confocal-laser-endomicroscopy-in-surgery-and-stereotactic-biopsy-of-low-grade-and-high-grade-gliomas-a-feasibility-study-in-humans
#19
Vladislav Pavlov, David Meyronet, Vincent Meyer-Bisch, Xavier Armoiry, Brian Pikul, Chloé Dumot, Pierre-Aurelien Beuriat, Francesco Signorelli, Jacques Guyotat
BACKGROUND: The management of gliomas is based on precise histologic diagnosis. The tumor tissue can be obtained during open surgery or via stereotactic biopsy. Intraoperative tissue imaging could substantially improve biopsy precision and, ultimately, the extent of resection. OBJECTIVE: To show the feasibility of intraoperative in vivo probe-based confocal laser endomicroscopy (pCLE) in surgery and biopsy of gliomas. METHODS: In our prospective observational study, 9 adult patients were enrolled between September 2014 and January 2015...
October 2016: Neurosurgery
https://www.readbyqxmd.com/read/27642847/a-review-of-probe-based-confocal-laser-endomicroscopy-for-pancreaticobiliary-disease
#20
Kunal Karia, Michel Kahaleh
Confocal laser endomicroscopy (CLE) is a novel in vivo imaging technique that can provide real-time optical biopsies in the evaluation of pancreaticobiliary strictures and pancreatic cystic lesions (PCLs), both of which are plagued by low sensitivities of routine evaluation techniques. Compared to pathology alone, CLE is associated with a higher sensitivity and accuracy for the evaluation of indeterminate pancreaticobiliary strictures. CLE has the ability to determine the malignant potential of PCLs. As such, CLE can increase the diagnostic yield of endoscopic retrograde cholangiopancreatography and endoscopic ultrasound, reducing the need for repeat procedures...
September 2016: Clinical Endoscopy
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