Read by QxMD icon Read


Luis A Buatois, John Almond, M Gabriela Mángano, Sören Jensen, Gerard J B Germs
Trace fossils of sediment bulldozers are documented from terminal Ediacaran strata of the Nama Group in Namibia, where they occur in the Spitskop Member of the Urusis Formation (Schwarzrand Subgroup). They consist of unilobate to bilobate horizontal to subhorizontal trace fossils describing scribbles, circles and, more rarely, open spirals and meanders, and displaying an internal structure indicative of active fill. Their presence suggests that exploitation of the shallow infaunal ecospace by relatively large bilaterians was already well underway at the dawn of the Phanerozoic...
March 14, 2018: Scientific Reports
Christian Schwedler, Thomas Häupl, Ulrich Kalus, Véronique Blanchard, Gerd-Rüdiger Burmester, Denis Poddubnyy, Berthold Hoppe
BACKGROUND: Galactosylation of immunoglobulin G (IgG) is reduced in rheumatoid arthritis (RA) and assumed to correlate with inflammation and altered humoral immunity. IgG hypogalactosylation also increases with age. To investigate dependencies in more detail, we compared IgG hypogalactosylation between patients with RA, patients with axial spondyloarthritis (axSpA), and healthy control subjects (HC), and we studied it in RA on the background of HLA-DRB1 shared epitope (SE), anticitrullinated protein antibodies (ACPA), and/or rheumatoid factor (RF) status...
March 14, 2018: Arthritis Research & Therapy
Joan Torres Puig-Gros, Rosa Mar Alzuria Alós
OBJECTIVE: Sometimes and when a registry is not available, influenza vaccination (IV) is based on vaccination records reported by citizens. When the opportunity of comparing both information sources exists, sometimes, discrepancies between both have been observed. The objectives of this study are: to know the IV coverage in pregnant women (both referred and recorded in the clinical history), to determine the concordance between both sources of information and to quantify the lost opportunities of IV due to errors in verbalization...
March 16, 2018: Revista Española de Salud Pública
Øystein A Haaland, Rolv T Lie, Julia Romanowska, Miriam Gjerdevik, Håkon K Gjessing, Astanand Jugessur
Background: It is widely accepted that cleft lip with or without cleft palate (CL/P) results from the complex interplay between multiple genetic and environmental factors. However, a robust investigation of these gene-environment (GxE) interactions at a genome-wide level is still lacking for isolated CL/P. Materials and Methods: We used our R-package Haplin to perform a genome-wide search for GxE effects in isolated CL/P. From a previously published GWAS, genotypes and information on maternal periconceptional cigarette smoking, alcohol intake, and vitamin use were available on 1908 isolated CL/P triads of predominantly European or Asian ancestry...
2018: Frontiers in Genetics
Erin A Bohula, Robert P Giugliano, Lawrence A Leiter, Subodh Verma, Jeong-Gun Park, Peter S Sever, Armando Lira Pineda, Narimon Honarpour, Huei Wang, Sabina A Murphy, Anthony Keech, Terje R Pedersen, Marc S Sabatine
BACKGROUND : In the FOURIER trial (Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Patients With Elevated Risk), the PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor evolocumab reduced low-density lipoprotein cholesterol (LDL-C) and cardiovascular risk. It is not known whether the efficacy of evolocumab is modified by baseline inflammatory risk. We explored the efficacy of evolocumab stratified by baseline high-sensitivity C-reactive protein (hsCRP). We also assessed the importance of inflammatory and residual cholesterol risk across the range of on-treatment LDL-C concentrations...
March 12, 2018: Circulation
Lutz E Kraushaar, Alexander Dressel, Alexander Maßmann
Undetected high risk for premature death of cardiovascular disease (CVD) among individuals with low-to-moderate risk factor scores is an acknowledged obstacle to CVD prevention. The vasculature's functional robustness against risk factor derailment may serve as a novel discriminator of mortality risk under similar risk factor loads. To test this assumption, we hypothesized that the expected inverse robustness-mortality association is verifiable as a significant trend along the age spectrum of risk factor-challenged cohorts...
March 2018: Preventive Medicine Reports
M Hermanussen, B Bogin, C Scheffler
AIM: To scrutinize to what extent modern ideas about nutrition effects on growth are supported by historic observations in European populations. METHOD: We reviewed 19th and early 20th century paediatric journals in the Staatsbibliothek zu Berlin, the third largest European library with an almost complete collection of the German medical literature. During a three-day visit, we inspected 15 bookshelf meters of literature not available in electronic format. RESULTS: Late 19th and early 20th century breastfed European infants and children, independent of social strata, grew far below World Health Organisation (WHO) standards and 15-30% of adequately-fed children would be classified as stunted by the WHO standards...
March 11, 2018: Acta Paediatrica
Larissa Galastri Baraldi, Euridice Martinez Steele, Daniela Silva Canella, Carlos Augusto Monteiro
OBJECTIVES: To compare ultra-processed food consumption across sociodemographic groups and over time (2007-2008, 2009-2010, 2011-2012) in the USA. DESIGN: Cross-sectional study. SETTING: National Health and Nutrition Examination Survey (NHANES) 2007-2012. PARTICIPANTS: All individuals aged ≥2 years with at least one 24-hour dietary recall were included (n=23 847). MAIN OUTCOME MEASURES: Average dietary contribution of ultra-processed foods (expressed as a percentage of the total caloric value of the diet), obtained after classifying all food items according to extent and purpose of industrial food processing using NOVA classification...
March 9, 2018: BMJ Open
Nabil Wasif, David Etzioni, Elizabeth B Habermann, Amit Mathur, Barbara A Pockaj, Richard J Gray, Yu-Hui Chang
BACKGROUND: Regionalization of complex visceral surgery across the United States has followed identification of a volume-outcome association. However, a simultaneous trend towards improved surgical outcomes may have attenuated this relationship. We hypothesize that the difference in adjusted postoperative mortality between low, medium and high volume hospitals has decreased over time. STUDY DESIGN: The National Inpatient Sample (NIS) was used to identify patients undergoing bladder, esophageal, pancreatic, liver, lung, and rectal surgery from 2003-2011...
March 7, 2018: Journal of the American College of Surgeons
Hyeonyoung Ko, Yun-Mi Song, Sang-Chol Lee, Seung Woo Park, Joohon Sung, Kayoung Lee, Eunae Lee
BACKGROUND: The objective of this study was to investigate the effect of excessive alcohol consumption on heart reflected by various echocardiographic parameters according to the presence or absence of flushing reaction that might reflect acetaldehyde metabolism. METHODS: A total of 854 Korean men without significant cardiovascular diseases who underwent echocardiography and participated in the Korean Healthy Twin Study were used as subjects of this study. These subjects were classified into three categories: non-drinker, moderate drinker (≤ 196 g/week), and heavy drinker (> 196 g/week) within two strata of flushing reaction to alcohol drinking...
March 10, 2018: Alcoholism, Clinical and Experimental Research
Nastaran Meschi, Steffen Fieuws, Anke Vanhoenacker, Olaf Strijbos, Dominique Van der Veken, Constantinus Politis, Paul Lambrechts
OBJECTIVES: The aim of this study was to investigate the impact of the adjunct of leukocyte- and platelet-rich fibrin (LPRF) to root-end surgery (RES) on the patients' quality of life during the first week post RES. MATERIALS AND METHODS: Patients in need of RES were recruited for an open randomized controlled clinical trial (RCT) with a 2 × 2 factorial design. They were randomly allocated to the test (+LPRF) and control (-LPRF) group. Each group was subsequently divided into two strata: with or without an occlusive membrane (Bio-Gide®, Geistlich Biomaterials, Switzerland; BG)...
March 9, 2018: Clinical Oral Investigations
N O Elander, K Aughton, P Ghaneh, J P Neoptolemos, D H Palmer, T F Cox, F Campbell, E Costello, C M Halloran, J R Mackey, A G Scarfe, J W Valle, A C McDonald, R Carter, N C Tebbutt, D Goldstein, J Shannon, C Dervenis, B Glimelius, M Deakin, R M Charnley, A Anthoney, M M Lerch, J Mayerle, A Oláh, M W Büchler, W Greenhalf
BACKGROUND: Deoxycytidylate deaminase (DCTD) and ribonucleotide reductase subunit M1 (RRM1) are potential prognostic and predictive biomarkers for pyrimidine-based chemotherapy in pancreatic adenocarcinoma. METHODS: Immunohistochemical staining of DCTD and RRM1 was performed on tissue microarrays representing tumour samples from 303 patients in European Study Group for Pancreatic Cancer (ESPAC)-randomised adjuvant trials following pancreatic resection, 272 of whom had received gemcitabine or 5-fluorouracil with folinic acid in ESPAC-3(v2), and 31 patients from the combined ESPAC-3(v1) and ESPAC-1 post-operative pure observational groups...
March 9, 2018: British Journal of Cancer
Nathan Ford, Zara Shubber, Joseph N Jarvis, Tom Chiller, Greg Greene, Chantal Migone, Marco Vitoria, Meg Doherty, Graeme Meintjes
Background: Current guidelines recommend screening all people living with human immunodeficiency virus (PLHIV) who have a CD4 count ≤100 cells/µL for cryptococcal antigen (CrAg) to identify those patients who could benefit from preemptive fluconazole treatment prior to the onset of meningitis. We conducted a systematic review to assess the prevalence of CrAg positivity at different CD4 cell counts. Methods: We searched 4 databases and abstracts from 3 conferences up to 1 September 2017 for studies reporting prevalence of CrAg positivity according to CD4 cell count strata...
March 4, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Daniel Olsson, Kristina Alexanderson, Matteo Bottai
Background: Previous studies showed that disability pensioners have a higher risk of premature death than others, but residual confounding has been suggested. The aim was to assess the degree of residual confounding of the association between disability pension (DP) and risk of premature death. Methods: Prospective cohort study of everyone aged 19-64 years, living in Sweden 31 December 2004 (n = 5 406 469), followed up through 2010. Mortality hazard rates over time were estimated for three groups; incident disability pensioners during 2005 from start of DP (February-December 2005), prevalent disability pensioners (January 2005 or since before), and individuals not on DP in January 2005, after standardizing populations to characteristics of the incident disability pensioners, stratified by previous hospitalization or not...
March 3, 2018: European Journal of Public Health
Jing-Hu Yang, Xiang Yu, Yi Yang, Zeng-Qiang Yang
Underground coal mining activities are prone to cause movement and breakage in geological strata and also lead to mining subsidence and even ground fissures. Along the direction working panel advancing, ground fissures may occur in roof in front and/or behind working panel. However, the investigations of previous similarity tests in lab only emphasize on the region behind working panel. By improving strata material property in construction and mounting artificial pressure devices, two physical simulation tests were conducted and successfully investigated the simulated results...
2018: PloS One
Janne Rossen, Kari Klungsøyr, Susanne Albrechtsen, Ellen Løkkegård, Steen Rasmussen, Thomas Bergholt, Finn Egil Skjeldestad
INTRODUCTION: Maternal age is an established risk factor for cesarean section, whereas epidural analgesia and oxytocin augmentation may modify this association. We investigated the effects and interactions of oxytocin augmentation, epidural analgesia and maternal age on the risk of cesarean section. MATERIAL AND METHODS: In all, 416 386 nulliparous women with spontaneous onset of labor, ≥ 37 weeks of gestation, singleton infants with a cephalic presentation during 2000-2011 from Norway and Denmark were included (Ten-Group Classification System (Robson) group 1)...
March 7, 2018: Acta Obstetricia et Gynecologica Scandinavica
Ester Moreno-Artero, Elena Querol-Cisneros, Nuria Rodríguez-Garijo, Alejandra Tomás-Velázquez, Javier Antoñanzas, Secundino Fernández, María Pilar Gil-Sánchez, Agustín España
Cocaine is an alkaloid extracted from the leaves of the Erythroxylum coca plant that emerged in the 1970s as a fashionable drug among members of certain social backgrounds. Cocaine abuse is a problem of current interest, which is mostly hidden and under-diagnosed, but dramatically widespread among all socioeconomic strata, and with an incidence which is increasing at an alarming rate. There are 1.5 million cocaine consumers in the USA. In Spain, the prevalence of consumption among the population between 15 and 65 years-old is higher, reaching 3...
March 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Khy Eam Eang, Toshifumi Igarashi, Ryota Fujinaga, Megumi Kondo, Carlito Baltazar Tabelin
Groundwater flow and its geochemical evolution in mines are important not only in the study of contaminant migration but also in the effective planning of excavation. The effects of groundwater on the stability of rock slopes and other mine constructions especially in limestone quarries are crucial because calcite, the major mineral component of limestone, is moderately soluble in water. In this study, evolution of groundwater in a limestone quarry located in Chichibu city was monitored to understand the geochemical processes occurring within the rock strata of the quarry and changes in the chemistry of groundwater, which suggests zones of deformations that may affect the stability of rock slopes...
March 6, 2018: Environmental Monitoring and Assessment
Adrian J Green, Cathrine Hoyo, Carolyn J Mattingly, Yiwen Luo, Jung-Ying Tzeng, Susan K Murphy, David B Buchwalter, Antonio Planchart
OBJECTIVE: Human obesity is a complex metabolic disorder disproportionately affecting people of lower socioeconomic strata, and ethnic minorities, especially African Americans and Hispanics. Although genetic predisposition and a positive energy balance are implicated in obesity, these factors alone do not account for the excess prevalence of obesity in lower socioeconomic populations. Therefore, environmental factors, including exposure to pesticides, heavy metals, and other contaminants, are agents widely suspected to have obesogenic activity, and they also are spatially correlated with lower socioeconomic status...
February 20, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Antoinette Percy-Laurry, Sean F Altekruse, Mian B Hossain, Anne Marie O'Keefe, Norman J Johnson, Farin Kamangar
BACKGROUND: Prostate cancer affects black men disproportionately. Black men have an increased incidence of prostate cancer diagnoses at earlier ages and higher grade as indicated by Gleason score, compared to other races. This study investigates the impact of socioeconomic status (SES) on prostate cancer tumor grade among black men. METHODS: Black men with a prostate cancer diagnosis during 1973-2011 were examined using individual-level data from the SEER NLMS database...
February 2018: Journal of the National Medical Association
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"