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Febuxostat

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https://www.readbyqxmd.com/read/29447788/the-influence-of-febuxostat-on-coronary-artery-endothelial-dysfunction-in-patients-with-coronary-artery-disease-a-phase-4-randomized-placebo-controlled-double-blind-crossover-trial
#1
Allison G Hays, Micaela Iantorno, Michael Schär, Shenghan Lai, Matthew Czarny, Elayne Breton, Robert N Palmer, Andrew Whelton, Robert G Weiss, Gary Gerstenblith
BACKGROUND: The xanthine oxidase (XO) system is a significant source of vascular oxidative stress, which is believed to impair endothelial function, an important contributor to atherosclerotic disease. We tested whether febuxostat, a potent XO inhibitor, improves coronary endothelial function (CEF) in patients with stable coronary artery disease (CAD) in a single-center, randomized, placebo-controlled, double-blind crossover trial. METHODS: CEF was measured using noninvasive magnetic resonance imaging (MRI) assessment of changes in 30 patients with stable CAD and baseline impaired CEF...
March 2018: American Heart Journal
https://www.readbyqxmd.com/read/29447370/management-of-gout-by-uk-rheumatologists-a-british-society-for-rheumatology-national-audit
#2
Edward Roddy, Jon Packham, Karen Obrenovic, Ali Rivett, Joanna M Ledingham
Objectives: To assess the concordance of gout management by UK rheumatologists with evidence-based best-practice recommendations. Methods: Data were collected on patients newly referred to UK rheumatology out-patient departments over an 8-week period. Baseline data included demographics, method of diagnosis, clinical features, comorbidities, urate-lowering therapy (ULT), prophylaxis and blood tests. Twelve months later, the most recent serum uric acid level was collected...
February 13, 2018: Rheumatology
https://www.readbyqxmd.com/read/29415653/xanthine-oxidase-inhibitors-for-prevention-of-cardiovascular-events-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#3
Markus Bredemeier, Lediane Moreira Lopes, Matheus Augusto Eisenreich, Sheila Hickmann, Guilherme Kopik Bongiorno, Rui d'Avila, André Luis Bittencourt Morsch, Fernando da Silva Stein, Guilherme Gomes Dias Campos
BACKGROUND: Xanthine oxidase inhibitors (XOI), classified as purine-like (allopurinol and oxypurinol) and non-purine (febuxostat and topiroxostat) XOI, present antioxidant properties by reducing the production of reactive oxygen species derived from purine metabolism. Oxidative stress is an important factor related to endothelial dysfunction and ischemia-reperfusion injury, and may be implicated in the pathogenesis of heart failure, hypertension, and ischemic heart disease. However, there is contradictory evidence regarding the possible cardiovascular (CV) protective effect exerted by XOI...
February 7, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29393124/treatment-of-hyperuricemia-in-chronic-kidney-disease
#4
Juan C Ramirez-Sandoval, Magdalena Madero
Hyperuricemia may be a major contributor to the development or progression of chronic kidney disease (CKD). Although there is no clear cutoff uric acid (UA) value associated to the risk for kidney damage, it appears to be an increased risk as UA rises. Lifestyle interventions such as exercise, weight reduction, low consumption of purine-rich meat, or avoiding high fructose intake are recommended for all hyperuricemic patients. Lowering urate drugs such as allopurinol or febuxostat may be an option as a renoprotective agent; yet, randomized clinical trials evaluating the safety and efficacy of these drugs are limited to a small number of single-center studies...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29390240/-hyperuricaemia-and-chronic-kidney-disease
#5
Carlo Garofalo, Toni De Stefano, Carlo Vita, Giorgia Vinci, Francesco Balia, Francesca Nettuno, Luisa Scarpati, Azzurra Sguazzo, Alessandra Sagliocchi, Mario Pacilio, Roberto Minutolo, Luca De Nicola, Silvio Borrelli
Hyperuricemia is defined as serum uric acid values greater than 6 mg/dl and could occur either due to hyperproduction or as a result of reduced renal excretion, which exceeds gut compensation. In Italy, prevalence is around 12% of the general population and increases in renal disease up to 60%. Recent experimental studies demonstrated a role of uric acid in the development of arterial hypertension and systemic arteriosclerosis, with an increase in cardiovascular risk. It also appears from observational studies that high uric acid is an independent risk factor associated with de novo onset of chronic kidney disease after adjustment of main confounding variables...
February 2018: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29386212/effective-uric-acid-reduction-with-probenecid-and-febuxostat-in-a-patient-with-chronic-kidney-disease
#6
Robert Case, Brian Wentworth, Grant Jester
A 33-year-old male with poorly controlled chronic tophaceous gout and chronic kidney disease (CKD) with estimated glomerular filtration rate (GFR) of 37 cc/min. His uric acid was 11 mg/dL despite maximal dosing of febuxostat. He had previously failed pegloticase infusions as well. This patient had a reduction in his uric acid level to less than 6 mg/dL following addition of probenecid to his febuxostat regimen. Most guidelines recommend against utilisation of probenecid therapy in patients with GFR <50, but there is no obvious contraindication to its use, provided renal calculi do not develop...
January 31, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29359786/uric-acid-upregulates-the-adiponectin%C3%A2-adiponectin-receptor%C3%A2-1-pathway-in-renal-proximal-tubule-epithelial-cells
#7
Qingmei Yang, Chensheng Fu, Jing Xiao, Zhibin Ye
Adiponectin (APN) is a protein hormone that is primarily derived from adipocytes. It can also be secreted by renal cells. Hypoadiponectinemia has been documented in patients with hyperuricemia, however, whether soluble uric acid (SUA) regulates the expression of APN and APN receptor 1 (AdipoR1) in renal proximal tubule epithelial cells (PTECs) remains to be elucidated. The present study investigated the expression of APN and AdipoR1 in cultured PTECs that were exposed to SUA through immunofluorescence and western blot analysis...
December 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29342419/investigation-of-the-transport-of-xanthine-dehydrogenase-inhibitors-by-the-urate-transporter-abcg2
#8
Makiko Nakamura, Kyoko Fujita, Yu Toyoda, Tappei Takada, Hiroshi Hasegawa, Kimiyoshi Ichida
Hyperuricemia induces gout and kidney stones and accelerates the progression of renal and cardiovascular diseases. Adenosine 5'-triphosphate-binding cassette subfamily G member 2 (ABCG2) is a urate transporter, and common dysfunctional variants of ABCG2, non-functional Q126X (rs72552713) and semi-functional Q141K (rs2231142), are risk factors for hyperuricemia and gout. A recent genome wide association study suggested that allopurinol, a serum uric acid-lowering drug that inhibits xanthine dehydrogenase, is a potent substrate of ABCG2...
November 22, 2017: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29340054/febuxostat-attenuates-er-stress-mediated-kidney-injury-in-a-rat-model-of-hyperuricemic-nephropathy
#9
Li He, Ying Fan, Wenzhen Xiao, Teng Chen, Jiejun Wen, Yang Dong, Yiyun Wang, Shiqi Li, Rui Xue, Liyang Zheng, John Cijiang He, Niansong Wang
Hyperuricemia contributes to kidney tubular injury and kidney fibrosis. However, the underlying mechanism remains unclear. Here we examined the role of RTN1A, a novel endoplasmic reticulum (ER)-associated protein and ER stress in hyperuricemic nephropathy. We first found the expression of RTN1A and ER stress markers was significantly increased in kidney biopsies of hyperuricemia patients with kidney injury. In a rat model of hyperuricemic nephropathy (HN) established by oral administration of a mixture of adenine and potassium oxonate, increased expression of RTN1A and ER stress was shown in tubular and interstitial compartment of rat kidneys...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29325307/-the-clinical-characteristics-diagnosis-and-treatment-of-patients-with-gout-in-china
#10
H Luo, W G Fang, X X Zuo, R Wu, X X Li, J W Chen, J G Zhou, J Yang, H Song, X J Duan, X F Lin, X W Zeng, H Zeng
Objective: To investigate the demographic characteristics, clinical features, diagnosis and treatment of patients with gout in China. Methods: Clinical data of 6 814 patients with gout from 100 hospitals in 27 provinces, municipalities or autonomous regions in China were collected and analyzed. Results: (1) The ratio of male to female in patients with gout was 14.7∶1. The mean age of onset was (48.8±15.1) years old. Mean serum urate level was (526.7±132.3) μmol/L. Patients' education background was of U-shaped distribution; (2) Hypertension was the most common comorbidity [15...
January 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29251581/efficacy-and-safety-of-febuxostat-in-kidney-transplant-patients
#11
Chung Hee Baek, Hyosang Kim, Won Seok Yang, Duck Jong Han, Su-Kil Park
OBJECTIVES: Febuxostat, a nonpurine xanthine oxidase, is known to be effective and safe, even in patients with chronic kidney disease. However, there are insufficient data about the efficacy and safety of febuxostat in kidney transplant patients. MATERIALS AND METHODS: We reviewed medical records of all kidney transplant patients who were prescribed febuxostat between August 2012 and May 2015 at Asan Medical Center in Seoul, Korea. The efficacy and safety results of febuxostat in transplant patients were evaluated...
December 18, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29250494/diagnosis-and-treatment-of-inflammatory-joint-disease
#12
REVIEW
Yeesuk Kim, Hyun-Cheol Oh, Jang Won Park, In-Sung Kim, Jun-Young Kim, Ki-Choul Kim, Dong-Sik Chae, Woo-Lam Jo, Joo-Hyoun Song
Arthritis damages the cartilage within joints, resulting in degenerative changes, including loss of function and joint instability. Ankylosing spondylitis (AS) is a chronic inflammatory condition affecting the spine and bone-to-tendon attachment area within the sacroiliac joint leading to back pain and progressive spinal stiffness. In the final stages, AS causes hyperkyphosis-a condition closely tied to the human leukocyte antigen-B27 gene. Rheumatoid arthritis is a chronic, systemic autoimmune disease characterized by the simultaneous inflammation of the synovium of multiple joints, leading to joint damage (e...
December 2017: Hip & Pelvis
https://www.readbyqxmd.com/read/29241594/comparison-of-the-effect-of-allopurinol-and-febuxostat-on-urinary-2-8-dihydroxyadenine-excretion-in-patients-with-aprt-deficiency-a-clinical-trial
#13
Vidar O Edvardsson, Hrafnhildur L Runolfsdottir, Unnur A Thorsteinsdottir, Inger M Sch Agustsdottir, G Steinunn Oddsdottir, Finnur Eiriksson, David S Goldfarb, Margret Thorsteinsdottir, Runolfur Palsson
INTRODUCTION: Adenine phosphoribosyltransferase (APRT) deficiency is a rare, but significant, cause of kidney stones and progressive chronic kidney disease. The optimal treatment has not been established. The purpose of this pilot study was to compare the effect of the xanthine oxidoreductase inhibitors allopurinol and febuxostat on urinary 2,8-dihydroxyadenine (DHA) excretion in APRT deficiency patients. MATERIALS AND METHODS: Patients listed in the APRT Deficiency Registry of the Rare Kidney Stone Consortium, currently receiving allopurinol therapy, were invited to participate...
December 11, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29217890/nontubercular-mycobacterial-infection-in-a-renal-allograft-recipient
#14
U Anandh, K Jayanna
A 71-year-old male, a renal allograft recipient, presented to us with a history of fever and right palm swelling. He had a history of fever 7 years back when he was treated with antitubercular treatment (ATT). Three years back, he was diagnosed to have gout and he was started on allopurinol. He developed severe bone marrow toxicity and allopurinol was changed to febuxostat. On admission, routine investigations did not reveal any focus of infection. The fluid aspirate from the palm revealed acid-fast bacilli (AFB)...
November 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/29204974/effects-of-discontinuation-of-urate-lowering-therapy-a-systematic-review
#15
Virginie Beslon, Perrine Moreau, Annabel Maruani, Hubert Maisonneuve, Bruno Giraudeau, Jean-Pascal Fournier
BACKGROUND: Urate-lowering therapy (ULT) is associated with low rates of adherence, leading to a potential risk of relapse of gouty arthritis, tophi, or urolithiasis. Our main aim was to identify the recurrence of gouty arthritis, tophi, or urolithiasis after discontinuation of ULT. Secondary aims included an assessment of ULT reintroduction rates and factors associated with relapse. METHODS: We conducted a systematic literature review of clinical studies investigating the effect of discontinuing any ULT (allopurinol, febuxostat, probenecid, sulfinpyrazone, benzbromarone) in adults on long-term therapy...
December 4, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29204859/improvement-in-diagnosis-and-treat-to-target-management-of-hyperuricemia-in-gout-results-from-the-gema-2-transversal-study-on-practice
#16
Fernando Perez Ruiz, Carlos A Sanchez-Piedra, Jesus T Sanchez-Costa, Mariano Andrés, Cesar Diaz-Torne, Mercedes Jimenez-Palop, Eugenio De Miguel, Carmen Moragues, Francisca Sivera
INTRODUCTION: The objective of the study was to evaluate changes regarding main European League Against Rheumatism (EULAR) recommendations on diagnosis and treatment of gout compared to a previous assessment. METHODS: The GEMA-2 (Gout Evaluation and MAnagement) is a transversal assessment of practice for gout by rheumatologists. Main outcome variables were improvement of the previous GEMA assessment regarding the rate of crystal-proven diagnosis and that reaching therapeutic serum urate target below 6 mg/dl at last visit...
December 4, 2017: Rheumatology and Therapy
https://www.readbyqxmd.com/read/29167547/crystal-arthritis-stepping-up-febuxostat-to-treat-gout-flares
#17
Joanna Collison
No abstract text is available yet for this article.
November 23, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/29165620/comparative-effectiveness-of-allopurinol-febuxostat-and-benzbromarone-on-renal-function-in-chronic-kidney-disease-patients-with-hyperuricemia-a-13-year-inception-cohort-study
#18
Hsu-Wen Chou, Hsien-Tsai Chiu, Ching-Wei Tsai, I-Wen Ting, Hung-Chieh Yeh, Han-Chun Huang, Chin-Chi Kuo
Background: Direct comparisons of the effectiveness of allopurinol with that of other urate-lowering agents in chronic kidney disease (CKD) populations, as well as guideline recommendations for clinical practice, are lacking. Methods: We constructed a pharmacoepidemiology cohort study by including patients from Taiwan's long-term integrated CKD care program to compare the effectiveness among allopurinol, febuxostat and benzbromarone in reducing the risk of progression to dialysis...
November 17, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29138678/febuxostat-modulates-mapk-nf-%C3%AE%C2%BAbp65-tnf-%C3%AE-signaling-in-cardiac-ischemia-reperfusion-injury
#19
Sana Irfan Khan, Rajiv Kumar Malhotra, Neha Rani, Anil Kumar Sahu, Ameesha Tomar, Shanky Garg, Tapas Chandra Nag, Ruma Ray, Shreesh Ojha, Dharamvir Singh Arya, Jagriti Bhatia
Xanthine oxidase and xanthine dehydrogenase have been implicated in producing myocardial damage following reperfusion of an occluded coronary artery. We investigated and compared the effect of febuxostat and allopurinol in an experimental model of ischemia-reperfusion (IR) injury with a focus on the signaling pathways involved. Male Wistar rats were orally administered vehicle (CMC) once daily (sham and IR + control), febuxostat (10 mg/kg/day; FEB10 + IR), or allopurinol (100 mg/kg/day; ALL100 + IR) for 14 days...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29129858/green-electroanalytical-method-for-fast-measurement-of-xanthine-oxidase-inhibitor-febuxostat
#20
Biljana Nigovic, Ivona Milanovic
The electrooxidation of xanthine oxidase inhibitor febuxostat was investigated on a boron-doped diamond electrode in aqueous solution. The oxidation of the drug molecule was irreversible and exhibited a diffusion-controlled form. A green electroanalytical method for simple and fast measurements of febuxostat was developed at the unmodified electrode surface. The analyses were performed using square-wave voltammetric peak current at 1.38 V. The linear response was obtained in the range of 7.5 × 10(-7) - 2.0 × 10(-5) M with the detection limit of 9...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
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