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Cisplantin

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https://www.readbyqxmd.com/read/26903157/-sirt1-influences-the-sensitivity-of-a549-non-small-cell-lung-cancer-cell-line-to-%C3%A2-cisplatin-via-modulating-the-noxa-expression
#1
Bin Cao, Xiaofeng He, Wengong Wang, Minke Shi
BACKGROUND: The resistance of non-small cell lung cancer cells to cisplant is a common clinical phenomenon which could induce a poor therapeutic effect and should be difficult problem to be solved. SIRT1 and Noxa expression are associated with the chemotherapy for tumors. The present study focused on how SIRT1 expression influence the senstivity of non-small cell lung cancer cells and dissected the potential mechanism involved with Noxa. METHODS: The difference of SIRT1 and Noxa expression between A549 cells and A549/DDP cells was detected by real-time quantitative PCR (qRT-PCR) and Western blot...
February 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/25513112/postoperative-chemoradiotherapy-for-advanced-gastric-cancer-after-d2-gastrectomy
#2
Xia Deng, Xiance Jin, Shengliu Xue, Xuebang Zhang, Huafang Su, Ping Zhang, Congying Xie
BACKGROUND/AIMS: The purpose of this study is to investigate the role of postoperative chemoradiotherapy with paclitaxel and cisplatin in the multimodality treatment of locally advanced gastric cancer after D2 gastrectomy. METHODOLOGY: Sixty-five patients underwent D2 gastrectomy with stage IB-IV (M0) gastric cancers were enrolled. A postoperative radiotherapy dose of 46 Gy in 23 fractions with concurrent chemotherapy of paclitaxel and cisplatin were delivered to the patients...
July 2014: Hepato-gastroenterology
https://www.readbyqxmd.com/read/25436327/postoperative-chemoradiotherapy-for-advanced-gastric-cancer-after-d2-gastrectomy
#3
Xia Deng, Xiance Jin, Shengliu Xue, Xuebang Zhang, Huafang Su, Ping Zhang, Congying Xie
BACKGROUND/AIMS: The purpose of this study is to investigate the role of postoperative chemoradiotherapy with paclitaxel and cisplatin in the multimodality treatment of locally advanced gastric cancer after D2 gastrectomy. METHODOLOGY: Sixty-five patients underwent D2 gastrectomy with stage IB-IV (M0) gastric cancers were enrolled. A postoperative radiotherapy dose of 46 Gy in 23 fractions with concurrent chemotherapy of paclitaxel and cisplatin were delivered to the patients...
July 2014: Hepato-gastroenterology
https://www.readbyqxmd.com/read/23323987/two-new-diterpenoids-from-excoecaria-acerifolia
#4
Xing-De Wu, Lan-Chun Zhang, Juan He, Gen-Tao Li, Lin-Fen Ding, Xiu Gao, Liao-Bin Dong, Liu-Dong Song, Yan Li, Qin-Shi Zhao
A new tigliane diterpenoid, acerifolin A (1), and a new isopimarane diterpenoid, acerifolin B (2), together with two known compounds, were isolated from Excoecaria acerifolia. Their structures were elucidated on the basis of their spectroscopic methods, including 1D and 2D NMR techniques. All of the compounds were evaluated for cytotoxicity against five human cancer cell lines with cisplantin as a positive control.
2013: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/22325224/-neoadjuvant-chemotherapy-with-paclitaxel-and-cisplantin-or-carboplatin-for-patients-with-locally-advanced-uterine-cervical-cancer
#5
Rong Zhang, Bin Li, Pin Bai, Hong-Jun Li, Shu-Min Li, Ling-Ying Wu, Wei Li
OBJECTIVE: To investigate the efficacy and toxicity of neoadjuvant chemotherapy with paclitaxel and carboplatin or cisplatin for patients with locally advanced cervical cancer. METHODS: A total of 70 patients with locally advanced cervical cancer were treated with neoadjuvant chemotherapy with paclitaxel and carboplatin or cisplatin in our department from July 2007 to May 2010. The stage distribution among the patients included 45 stage IB2, 21 stage IIa, and 4 stage IIb...
August 2011: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/18756608/a-case-of-long-survival-in-poorly-differentiated-small-cell-carcinoma-of-the-pancreas
#6
Min Sung Chung, Tae Kyung Ha, Kyeong Geun Lee, Seung Sam Paik
Small cell carcinoma (SCC) of the pancreas is rare. It has similar histological features to pulmonary small cell carcinoma and is equally aggressive. Most patients with SCC in the pancreas reported in case studies died within 1 year after diagnosis. We present a case of unusually long-term survival after surgery and combined chemotherapy for SCC of the pancreas. A 62-year-old woman presented with epigastric pain and jaundice. Computed tomography revealed dilated common bile duct caused by external compression of the mass in the pancreatic head...
August 21, 2008: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/18359722/-therapeutic-and-adverse-effects-of-topotecan-combined-with-cisplatin-for-treatment-of-advanced-squamous-cell-lung-cancer-and-head-and-neck-cancer
#7
Ying Xiang, Qi-ying Li, Jiang-he Shao, Jian-zhong Yang
OBJECTIVE: To evaluate the therapeutic and adverse effects of topotecan combined with cisplatin in the treatment of advanced squamous cell lung cancer and head and neck cancer. METHODS: Totally 126 patients with advanced squamous cell lung cancer and head and neck cancer, which were confirmed by tissue pathology or cytopathology, were treated with intravenous infusion of topotecan at the dose of 0.75-1.2 mg/m2 (for 5 consecutive days) combined with intravenous infusion of cisplantin at 25-30 mg/m2 for 3 consecutive days...
March 2008: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/18304605/malignant-advanced-granulosa-cell-tumor-of-the-adult-testis-case-report-and-review-of-the-literature
#8
REVIEW
Kai H Hammerich, Stephanie Hille, Gustavo E Ayala, Thomas M Wheeler, Rainer Engers, Rolf Ackermann, Volker Mueller-Mattheis
Testicular granulosa cell tumors (GCTs) are very rare neoplasms. Although adult GCTs are thought to have a relatively indolent course, several reports have demonstrated the malignant potential of these lesions. In case of distant metastases, the overall survival is very short. To date, there is no well-established treatment for these tumors owing to poor results and very rapid progression. A 55-year-old male patient was diagnosed with a testicular GCT with distant lung metastases. He underwent surgical treatment with orchiectomy and adjuvant polychemotherapy (cisplantine, etoposide, and bleomycine) as well as metastasectomy of the right lung...
May 2008: Human Pathology
https://www.readbyqxmd.com/read/18162154/-impact-of-rna-interference-targeting-hypoxia-inducible-factor-1alpha-on-chemosensitivity-in-esophageal-squamous-cell-carcinoma-cells-under-hypoxia
#9
Xin-Ai Wu, Yan Sun, Qing-Xia Fan, Liu-Xing Wang, Rui-Lin Wang, Lan Zhang
OBJECTIVE: To investigate the impact of RNA interference (RNAi) targeting hypoxia-inducible factor 1alpha (HIF-1 alpha) on chemosensitivity of esophageal squamous cell carcinoma cells under hypoxia. METHODS: Human esophageal squamous cell carcinoma cells of the line EC9706 were cultured and divided into 3 groups: untransfected group, added with cobalt chloride (CoCl(2)), a chemical hypoxia inducer, for 8 h so as to establish a hypoxia model; control siRNA transfected group, transfected with control siRNA, and 30 h after the transfection exposed to CoCl(2) for 8 h; and HIF-1 alpha siRNA-transfected group, transfected with HIF-1 alpha siRNA, and 30 h later exposed to CoCl(2) for 8 h...
October 9, 2007: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/16398598/polyphenol-contents-in-grape-seed-extracts-correlate-with-antipica-effects-in-cisplatin-treated-rats
#10
Chong-Zhi Wang, Anna Fishbein, Han H Aung, Sangeeta R Mehendale, Wei-Tien Chang, Jing-Tian Xie, Jing Li, Chun-Su Yuan
BACKGROUND: Grape-seed (Vitis spp.) extract (GSE) is a widely used antioxidant dietary supplement. Chemotherapeutic agents such as cisplatin induce oxidative damage in the gastrointestinal tract and cause nausea and vomiting. MATERIALS AND METHODS: A rat model of simulated emesis was used to observe that cisplatin significantly increased kaolin consumption (or pica). Three GSEs from different sources were used in this study. RESULTS: High-performance liquid chromatographic analysis of five major constituents (gallic acid, catechin, epicatechi, procyanidin B2, and epicatechin gallate) revealed that each constituent had different levels in the three GSEs...
December 2005: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/16253169/-late-course-conformal-radiotherapy-combined-with-chemotherapy-for-stage-iii-and-iv-a-nasopharyngeal-carcinoma
#11
RANDOMIZED CONTROLLED TRIAL
Hua Wu, Qing Lin, Zhong-hua Yu, Zhi-xiong Yang, Li-ping Feng
OBJECTIVE: To evaluate the effect and acute toxicity of late course conformal radiotherapy combined with chemotherapy for stage III and IV a nasopharyngeal carcinoma (NPC). METHODS: Ninety-six patients with stage III and IV a NPC were randomly divided into 2 groups: test group (n = 46, undergoing late course conformal radiotherapy combined with chemotherapy) and control group (n = 50, undergoing conventional radiotherapy). Both groups were treated with one-period chemotherapy, including cisplantin, 5-fluouracil, and calcium folinate, before and after the radiotherapy...
July 6, 2005: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/15599007/spleen-preserving-distal-pancreatectomy-following-neoadjuvant-chemotherapy-for-papillary-solid-and-cystic-neoplasm-of-pancreas
#12
Ganesh Das, Chidananda Bhuyan, Bhabesh Kumar Das, Jagannath Deb Sharma, Bhargab Jyoti Saikia, Joydeep Purkystha
Papillary solid and cystic neoplasm (PSCN) is a rare neoplasm of the pancreas with low-grade malignant potential and favorable prognosis. We report an 18-year-old girl with PSCN presenting with advanced disease. The tumor regressed with six cycles of gemcitabine and cisplantin-based neoadjuvant chemotherapy; spleen-preserving distal pancreatectomy was then done. She is disease-free at 13 months' follow-up.
September 2004: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/14680612/-study-of-ceramide-monohexoside-in-ovarian-cell-line-coc1-ddp-resistant-to-cisplantin
#13
Tang-ni Qin, Li-li Wang, Hong-gui Chen, Qing-hua Gao, Rong-xiang Zhou, Bao-zheng Sun, Qiang-wu Wang
OBJECTIVE: To investigate the effect of ceramide monohexoside (CMH) on resistance to cisplatin and apoptosis in ovarian cell line COC1/DDP, and to provide new ideals and clues to seek new effective methods for studying the mechanism and reversing the resistance in ovarian cell line as well. METHODS: COC1 cells and COC1/DDP cells (before and after the treatment of mifepristone) were collected and neutral glycosphingolipids (N-GSLs) of the cells was isolated and purified, changes of CMH content were analyzed by high performance thin layer chromatography (HPTLC)...
September 2003: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/9554591/differential-effects-of-all-trans-retinoic-acid-docosahexaenoic-acid-and-hexadecylphosphocholine-on-cisplatin-induced-cytotoxicity-and-apoptosis-in-a-cisplantin-sensitive-and-resistant-human-embryonal-carcinoma-cell-line
#14
H Timmer-Bosscha, E G de Vries, C Meijer, J W Oosterhuis, N H Mulder
Apart from modulation of tumor-cell drug sensitivity, induction of differentiation might be an alternative in the treatment of tumors resistant to cytotoxic drugs. In this report the capacity to induce differentiation and to modulate the cis-diamminedichloroplatinum(II) (CDDP) sensitivity of all-trans-retinoic acid (RA), docosahexaenoic acid (DCHA), and hexadecylphosphocholine (HePC) is examined in human germ-cell tumor cell lines. In the embryonal carcinoma cell line Tera-2 and its 3.7-fold CDDP-resistant subline Tera2-CP, we evaluated the effects of 96 h of pretreatment with RA (0...
1998: Cancer Chemotherapy and Pharmacology
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