Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Hatice Feray Arı, Adem Keskin, Murat Arı, Recai Aci
Aim: To evaluate the lactate/albumin ratio and its relation to mortality in children with nosocomial infections. Materials & methods: One hundred six children were included in this study. Blood gas and albumin levels were analyzed at the first, 24th and 48th h. Results: The types of detected microbial agents, signs of sepsis, development of septic shock and mortality rates were different. The first-, 24th- and 48th h lactate levels of the children who died were higher than those of the living children, but the albumin levels were lower...
November 14, 2023: Future Microbiology
#22
JOURNAL ARTICLE
The Effects of Heparan Sulfate Infusion on Endothelial and Organ Injury in a Rat Pneumosepsis Model.
Daan P van den Brink, Derek J B Kleinveld, Annabel Bongers, Jaël Vos, Joris T H Roelofs, Nina C Weber, Jaap D van Buul, Nicole P Juffermans
Septic shock is characterized by endothelial dysfunction, leading to tissue edema and organ failure. Heparan sulfate (HS) is essential for vascular barrier integrity, possibly via albumin as a carrier. We hypothesized that supplementing fluid resuscitation with HS would improve endothelial barrier function, thereby reducing organ edema and injury in a rat pneumosepsis model. Following intratracheal inoculation with Streptococcus pneumoniae, Sprague Dawley rats were randomized to resuscitation with a fixed volume of either Ringer's Lactate (RL, standard of care), RL supplemented with 7 mg/kg HS, 5% human albumin, or 5% human albumin supplemented with 7 mg/kg HS ( n = 11 per group)...
October 10, 2023: Journal of Clinical Medicine
#23
JOURNAL ARTICLE
Chun-Yuan Hsiao, Tsung-Yu Huang, Li-Yun Teng, Hung-Yen Chen, Cheng-Ting Hsiao, Yao-Hung Tsai, Shu-Fang Kuo
Necrotizing fasciitis (NF) is a life-threatening infection. Skin necrosis is an important skin sign of NF. The purposes of this study was to investigate the initial skin conditions of Vibrio NF patients between emergency room (ER) to preoperative status, to compare the clinical and laboratory risk indicators of the skin necrosis group and non-skin necrosis group when they arrived at ER, and to evaluate whether initial cutaneous necrosis related to fulminant course and higher fatalities. From 2015 to 2019, seventy-two Vibrio NF patients with surgical confirmation were enrolled...
October 27, 2023: Scientific Reports
#24
JOURNAL ARTICLE
Wenqing Yuan, Xiaozhuan Zhou, Zhigao Cai, Junyu Qiu, Xi Li, Gangling Tong
BACKGROUND: Despite medical progress, mortality from gastrointestinal perforation was relatively high. Our study's objective was to identify risk factors associated with a poor prognosis for gastrointestinal perforation. METHODS: Patients diagnosed with gastrointestinal perforation at the Longchuan County People's Hospital between January 2019 and February 2022 were the subject of a retrospective analysis of their laboratory data. Patients were grouped based on length of hospital stay, septic shock, and mortality...
2023: International Journal of General Medicine
#25
Atsushi Kosaka, Takao Goto, Takuya Washino, Naoya Sakamoto, Sentaro Iwabuchi, Fukumi Nakamura-Uchiyama
Systemic Capillary Leak Syndrome (SCLS) is a rare disease that causes severe distributive shock provoked by infection or vaccination. SCLS is clinically diagnosed by a triad of distributive shock, paradoxical hemoconcentration, and hypoalbuminemia. SCLS associated with coronavirus disease (COVID-19) in adults has not been reported yet in Japan. Case 1: A 61-year-old woman with fever, sore throat, headache, and muscle pain was admitted to our emergency department with suspected COVID-19. She had been diagnosed with SCLS 3 years earlier...
October 14, 2023: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
#26
REVIEW
Shahid Qayyum, Kamran Shahid
Sepsis is a life-threatening organ failure caused by a dysregulated response to infection. Fluid resuscitation and vasopressors are used to maintain systolic blood pressure and organ perfusion. Fluid resuscitation can be done with liberal or restricted fluids as well as colloids or crystalloid fluids. This review analyses the evidence for the use of liberal or restrictive fluids and colloids or crystalloids for the management of sepsis. A methodical search was conducted across PubMed, Cochrane Library, and ScienceDirect, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines were followed for this study...
August 2023: Curēus
#27
REVIEW
Christian J Wiedermann
BACKGROUND: Human albumin, a vital plasma protein with diverse molecular properties, has garnered interest for its therapeutic potential in various diseases, including critical illnesses. However, the efficacy of albumin infusion in critical care and its associated complications remains controversial. To address this, a review of recent meta-analyses was conducted to summarize the evidence pertaining to albumin use in critical illness. METHODS: Adhering to the rapid review approach, designed to provide a concise synthesis of existing evidence within a short timeframe, relevant meta-analyses published in the last five years were identified and analyzed...
September 12, 2023: Journal of Clinical Medicine
#28
JOURNAL ARTICLE
Danni Wang, Chaodi Luo, Qian Li, Tingting Zheng, Pengjie Gao, Boxiang Wang, Zhenzhen Duan
It has been demonstrated that lactate/albumin (L/A) ratio is substantially relevant to the prognosis of sepsis, septic shock, and heart failure. However, there is still debate regarding the connection between the L/A ratio and severe acute myocardial infarction (AMI). The aim of this study is to determine the prognostic role of L/A ratio in patients with severe AMI. Our retrospective study extracted data from the Medical Information Mart for Intensive Care III (MIMIC-III) database, included 1,134 patients diagnosed with AMI...
September 20, 2023: Scientific Reports
#29
JOURNAL ARTICLE
Daan P van den Brink, Derek J B Kleinveld, Annabel Bongers, Jaël Vos, Joris J T H Roelofs, Nina C Weber, Jaap D van Buul, Nicole P Juffermans
BACKGROUND: Endothelial injury and permeability are a hallmark of sepsis. Initial resuscitation of septic patients with crystalloids is associated with aggravation of endothelial permeability, which may be related either to low protein content or to volume. We investigated whether initial resuscitation with different types of plasma or albumin decreases endothelial dysfunction and organ injury in a pneumosepsis rat model compared to the same volume of crystalloids. STUDY DESIGN AND METHODS: Sprague-Dawley rats were intratracheally inoculated with Streptococcus pneumoniae...
September 20, 2023: Intensive Care Medicine Experimental
#30
JOURNAL ARTICLE
J Z Altamimi, N A Alfaris, G M Alshammari, R I Alagal, D H Aljabryn, M A Yahya
Diabetic nephropathy (DN) is the major microvascular complication of type 1 diabetes mellitus (T1DM). Impairment in adenosine monophosphate-activated protein kinase (AMPK) activity was shown to mediate the pro-oxidant and inflammatory mechanisms underlying DN. Isosteviol (ISV), isolated from Stevia rebaudiana, has antioxidant and anti-inflammatory properties and alleviates non-alcoholic fatty liver disease and lethal septic shock by activating AMPK. The effect of ISV on DN is unknown. This study examined if ISV alleviates DN in T1DM in adult male rats by activating AMPK...
June 2023: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
#31
JOURNAL ARTICLE
Stamatios Kokkinakis, Evangelos I Kritsotakis, Konstantinos Paterakis, Garyfallia-Apostolia Karali, Vironas Malikides, Anna Kyprianou, Melina Papalexandraki, Charalampos S Anastasiadis, Odysseas Zoras, Nikolas Drakos, Ioannis Kehagias, Dimitrios Kehagias, Nikolaos Gouvas, Georgios Kokkinos, Ioanna Pozotou, Panayiotis Papatheodorou, Kyriakos Frantzeskou, Dimitrios Schizas, Athanasios Syllaios, Ifaistion M Palios, Konstantinos Nastos, Markos Perdikaris, Nikolaos V Michalopoulos, Ioannis Margaris, Evangelos Lolis, Georgia Dimopoulou, Dimitrios Panagiotou, Vasiliki Nikolaou, Georgios K Glantzounis, George Pappas-Gogos, Kostas Tepelenis, Georgios Zacharioudakis, Savvas Tsaramanidis, Ioannis Patsarikas, Georgios Stylianidis, Georgios Giannos, Michail Karanikas, Konstantinia Kofina, Markos Markou, Emmanuel Chrysos, Konstantinos Lasithiotakis
PURPOSE: Emergency laparotomy (EL) is a common operation with high risk for postoperative complications, thereby requiring accurate risk stratification to manage vulnerable patients optimally. We developed and internally validated a predictive model of serious complications after EL. METHODS: Data for eleven carefully selected candidate predictors of 30-day postoperative complications (Clavien-Dindo grade > = 3) were extracted from the HELAS cohort of EL patients in 11 centres in Greece and Cyprus...
August 31, 2023: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
#32
JOURNAL ARTICLE
Jaime Fernández-Sarmiento, Ricardo Hernández-Sarmiento, María Paula Salazar, Sofia Barrera, Valeria Castilla, Catalina Duque
OBJECTIVE: The objective of this study was to evaluate the association between serum albumin levels and microcirculation changes, glycocalyx degradation, and the clinical outcomes of interest. METHODS: Observational, prospective study in children with sepsis. The primary outcome was the association between hypoalbuminemia and microcirculation disorders, endothelial activation and glycocalyx degradation using a perfused boundary region (PBR) (abnormal >2.0 μm on sublingual video microscopy) or plasma biomarkers (syndecan-1, angiopoietin-2)...
August 28, 2023: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
#33
JOURNAL ARTICLE
Gerd Klinkmann, Katja Waterstradt, Sebastian Klammt, Kerstin Schnurr, Jens-Christian Schewe, Reinhold Wasserkort, Steffen Mitzner
Human serum albumin (HSA) as the most abundant plasma protein carries multifunctional properties. A major determinant of the efficacy of albumin relies on its potent binding capacity for toxins and pharmaceutical agents. Albumin binding is impaired in pathological conditions, affecting its function as a molecular scavenger. Limited knowledge is available on the functional properties of albumin in critically ill patients with sepsis or septic shock. A prospective, non-interventional clinical trial assessed blood samples from 26 intensive care patients...
August 8, 2023: International Journal of Molecular Sciences
#34
JOURNAL ARTICLE
Jieen Huang, Yanzhu Chen, Ming Li, Shujin Xie, Huasheng Tong, Zhusheng Guo, Yi Chen
BACKGROUND: Hypervirulent Klebsiella pneumoniae (hvKP) is emerging globally and can cause various, severe infections in healthy individuals. However, the clinical manifestations of hvKP infections are nonspecific, and there is no gold standard for differentiating hvKP strains. Our objective was to develop prognostic models for estimating severity of disease and predicting 30-day all-cause mortality in patients with hvKP infections. METHODS: We enrolled 116 patients diagnosed with hvKP infections and obtained their demographic and clinical data...
August 25, 2023: BMC Infectious Diseases
#35
JOURNAL ARTICLE
Chengyu Yang, Yu Jiang, Cailin Zhang, Yu Min, Xin Huang
BACKGROUND: Septic patients with diabetes mellitus (DM) are more venerable to subsequent complications and the resultant increase in associated mortality. Therefore, it is important to make tailored clinical decisions for this subpopulation at admission. METHOD: Data from large-scale real-world databases named the Medical Information Mart for Intensive Care Database (MIMIC) were reviewed. The least absolute selection and shrinkage operator (LASSO) was performed with 10 times cross-validation methods to select the optimal prognostic factors...
2023: Frontiers in Endocrinology
#36
JOURNAL ARTICLE
Li-Na Pan, Shen-Ao Pan, Guang-Liang Hong, Kun-Wei Chen
PURPOSE: Acute cholangitis (AC) is a widespread acute inflammatory disease and the main cause of septic shock, which has a high death rate in hospitals. At present, the prediction models for short-term mortality of AC patients are still not ideal. We aimed at developing a new model that could forecast the short-term mortality rate of AC patients. METHODS: Data were extracted from the Medical Information Mart for Intensive Care IV version 2.0 (MIMIC-IV v2.0). There were a total of 506 cases of AC patients that were included...
2023: Emergency Medicine International
#37
JOURNAL ARTICLE
Gianni Turcato, Arian Zaboli, Serena Sibilio, Eleonora Rella, Antonio Bonora, Francesco Brigo
BACKGROUND: Assessing the evolutive risk of septic patients in the emergency department (ED) is very complex. Predictive tools are available, but at an early stage, none of them can detect the tissue microvascular alterations underlying the septic process. Hypoalbuminemia is present in critically ill patients in the ICU, and some early indications also suggest its early role in septic patients. AIM: To investigate the role of serum albumin concentration in predicting 30-day mortality among patients with sepsis at their first evaluation in the ED...
August 10, 2023: Internal and Emergency Medicine
#38
JOURNAL ARTICLE
Beibei Yang, Zhenbin Wei, Meiqing Wu, Yongrong Lai, Weihua Zhao
SUMMARY OBJECTIVE: To assess the clinical features and outcomes of hematological disease patients with Candida tropicalis bloodstream infections and determine the antifungal susceptibility of C. tropicalis . METHODS: This is a retrospective, single-center, observational study conducted in the Department of Hematology at The First Affiliated Hospital of Guangxi Medical University from January 2013 to December 2021. A total of 26 hematological disease patients with C...
2023: Frontiers in Microbiology
#39
JOURNAL ARTICLE
Jinjin Wang, Mengyao Wang, Ailin Zhao, Hui Zhou, Mingchun Mu, Xueting Liu, Ting Niu
BACKGROUND: In recent years, with the continuous development of treatments for hematological malignancies (HMs), the remission and survival rates of patients with HMs have been significantly improved. However, because of severe immunosuppression and long-term recurrent neutropenia during treatment, the incidence and mortality of bloodstream infection (BSI) were all high in patients with HMs. Therefore, we analyzed pathogens' distribution and drug-resistance patterns and developed a nomogram for predicting 30-day mortality in patients with BSIs among HMs...
2023: Frontiers in Cellular and Infection Microbiology
#40
JOURNAL ARTICLE
Lívia Guimarães, Juliana Piedade, Joana Duarte, Caroline Baldin, Lívia Victor, Barbara Costa, Zulane Veiga, Camila Alcântara, Flávia Fernandes, Gustavo Pereira
BACKGROUND/OBJECTIVES: Bacterial infections (BIs) are well-recognized precipitants of hepatic encephalopathy (HE). Nevertheless, there is a paucity of data in patients with HE associated with BI. Our aim was to describe clinical characteristics, recurrence, and prognosis of HE in patients with BI. METHODS: A prospective study with inclusion of hospitalized cirrhotic patients with BI, followed until discharge, death, or liver transplantation . RESULTS: 172 patients (age 57 ± 13, model of end-stage liver disease [MELD]-sodium 22 ± 8) were included...
2023: Journal of Clinical and Experimental Hepatology
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
