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HPV and HN cancers

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https://www.readbyqxmd.com/read/27575972/human-papillomavirus-as-a-favorable-prognostic-factor-in-a-subset-of-head-and-neck-squamous-cell-carcinomas-a-meta-analysis
#1
Hongwei Liu, Jintao Li, Yubai Zhou, Qin Hu, Yi Zeng, Mohammadzad Mehryar Mohammadreza
Many epidemical and biological studies have proposed that human papillomavirus (HPV), primarily high-risk HPV16/18, is an etiological factor for a subset of head and neck (HN) cancers. On that premise, we systematically reviewed relevant articles and improved the understanding of HPV-related cancers. This article comprehensively described the characteristics of HPV-associated HN tumors according to demography, histopathology, molecular biology, and prognosis. Meta-analyses were conducted to combine the studies that reported the association between HPV status and these variables using Rev Man 5...
August 30, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27098618/prognostic-significance-of-p16-cellular-localization-in-oropharyngeal-squamous-cell-carcinoma
#2
Syeling Lai, Ashley E Wenaas, Vlad C Sandulache, Christine Hartman, Elizabeth Chiao, Jennifer Kramer, Jose P Zevallos
OBJECTIVE: p16 immunohistochemical expression serves as a surrogate for human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC). While HPV-positive OPSCC commonly demonstrates prominent nuclear expression, aberrant cytoplasmic expression has been demonstrated in tobacco-related head and neck cancers. The purpose of this study is to investigate the prognostic significance of p16 cellular localization in OPSCC. METHODS: Retrospective cohort study and immunohistochemical expression analysis of 159 OPSCC patients treated at a tertiary-care Veterans Affairs Medical Center...
2016: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/26094074/impact-of-retropharyngeal-adenopathy-on-distant-control-and-survival-in-hpv-related-oropharyngeal-cancer-treated-with-chemoradiotherapy
#3
Stuart E Samuels, Jeffrey Vainshtein, Matthew E Spector, Mohannad Ibrahim, Jonathan B McHugh, Yebin Tao, Matthew Schipper, Francis Worden, Avraham Eisbruch
PURPOSE: Retropharyngeal adenopathy (RPA) is poor prognostic factor in head and neck (HN) cancer. However, the prognostic significance of RPA in Human Papillomavirus-related (HPV+) oropharyngeal cancer (OPC) is unknown. PATIENTS AND METHODS: 185 patients with HPV+OPC were assessed. Pre-therapy images reviewed by a HN radiologist to determine presence of RPA. Doses to the RPAs were determined from treatment plans. Outcomes analyzed using Kaplan-Meier method, log-rank tests, and correlations determined using Spearman's rank analyses...
July 2015: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/25618223/cytologic-evaluation-of-cervical-lymph-node-metastases-from-cancers-of-unknown-primary-origin
#4
REVIEW
Marc P Pusztaszeri, William C Faquin
Fine-needle aspiration biopsy (FNAB) is often the first diagnostic procedure performed in patients with head and neck (HN) masses. Metastatic squamous cell carcinoma (SCC) to cervical lymph nodes is by far the most common malignancy aspirated in the HN, but in approximately 3-10% of patients, a primary tumor will not be found even after complete clinico-radiological workup. Several HN cancers are associated with oncogenic viruses, including HPV-associated SCC and EBV-associated nasopharyngeal carcinoma (NPC)...
January 2015: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/25042671/incidence-of-ano-genital-and-head-and-neck-malignancies-in-women-with-a-previous-diagnosis-of-cervical-intraepithelial-neoplasia
#5
Marc Gaudet, Jeremy Hamm, Christina Aquino-Parsons
OBJECTIVE: The objective of this study was to determine if women with a history of Cervical Intraepithelial Neoplasia grades 2 and 3 (CIN2 and CIN3) are at increased long-term risk for developing non-cervix HPV-related malignancies. MATERIAL AND METHODS: Women diagnosed with CIN2 or CIN3 between 1980 and 2005 were identified from the British Columbia (BC) Cancer Agency Cervical Cancer Screening Program's database. These patients' records were then cross-referenced with the BC Cancer Registry for diagnosis of vulvar, vaginal, anal or head and neck (HN) cancers during the period subsequent to their diagnosis of CIN...
September 2014: Gynecologic Oncology
https://www.readbyqxmd.com/read/24765613/high-risk-hpvs-and-human-carcinomas-in-the-syrian-population
#6
REVIEW
Ala-Eddin Al Moustafa, Lina Ghabreau, Nizar Akil, Samer Rastam, Amal Alachkar, Amber Yasmeen
Human papillomavirus (HPV) infection is the most common sexually transmitted infection; persistent infection with high-risk types of HPV present a major risk factor for the initiation and progression of a variety of human carcinomas including cervical, colorectal, head, and neck (HN) as well as breast carcinomas. A huge number of studies investigated and reported the incidence of high-risk HPVs in these cancers worldwide particularly in the developed countries; therefore, two HPV prophylactic vaccines against the two most frequent high-risk HPV types (16 and 18) have been developed and used worldwide...
2014: Frontiers in Oncology
https://www.readbyqxmd.com/read/24719866/proteomic-study-of-hpv-positive-head-and-neck-cancers-preliminary-results
#7
GĂ©raldine Descamps, Ruddy Wattiez, Sven Saussez
Human papillomavirus (HPV) was recently recognized as a new risk factor for head and neck squamous cell carcinoma. For oropharyngeal cancers, an HPV+ status is associated with better prognosis in a subgroup of nonsmokers and nondrinkers. However, HPV infection is also involved in the biology of head and neck carcinoma (HNC) in patients with a history of tobacco use and/or alcohol consumption. Thus, the involvement of HPV infection in HN carcinogenesis remains unclear, and further studies are needed to identify and analyze HPV-specific pathways that are involved in this process...
2014: BioMed Research International
https://www.readbyqxmd.com/read/23296123/immunotherapy-in-new-pre-clinical-models-of-hpv-associated-oral-cancers
#8
Francesca Paolini, Silvia Massa, Isabella Manni, Rosella Franconi, Aldo Venuti
Cervical, anal, penile and a sub-set of head and neck (HN) tumors are critical health problems caused by high risk Human Papilloma Viruses (HPVs), like HPV type 16. No specific/effective pharmacological treatments exist. A valid preventive vaccination as well as the immunotherapy of persistent infections, pre-cancerous lesions or early-stage cancers could drive the HPV disease burden down. These treatments might be featured through low-cost platforms like those based on DNA and plant biotechnologies to produce tailored and enhanced formulations taking profit from the use of plants as bio-factories and as a source of immune-stimulators...
March 2013: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/22735904/different-cellular-p16-ink4a-localisation-may-signal-different-survival-outcomes-in-head-and-neck-cancer
#9
N Zhao, M-K Ang, X-Y Yin, M R Patel, K Fritchie, L Thorne, K L Muldrew, M C Hayward, W Sun, M D Wilkerson, B S Chera, T Hackman, A M Zanation, J E Grilley-Olson, M E Couch, W W Shockley, M C Weissler, C G Shores, W K Funkhouser, A F Olshan, D N Hayes
BACKGROUND: Recently, the management of head and neck squamous cell carcinoma (HNSCC) has focused considerable attention on biomarkers, which may influence outcomes. Tests for human papilloma infection, including direct assessment of the virus as well as an associated tumour suppressor gene p16, are considered reproducible. Tumours from familial melanoma syndromes have suggested that nuclear localisation of p16 might have a further role in risk stratification. We hypothesised p16 staining that considered nuclear localisation might be informative for predicting outcomes in a broader set of HNSCC tumours not limited to the oropharynx, human papilloma virus (HPV) status or by smoking status...
July 24, 2012: British Journal of Cancer
https://www.readbyqxmd.com/read/22376902/evaluation-of-a-combined-triple-method-to-detect-causative-hpv-in-oral-and-oropharyngeal-squamous-cell-carcinomas-p16-immunohistochemistry-consensus-pcr-hpv-dna-and-in-situ-hybridization
#10
Giuseppe Pannone, Vito Rodolico, Angela Santoro, Lorenzo Lo Muzio, Renato Franco, Gerardo Botti, Gabriella Aquino, Maria Carmela Pedicillo, Simona Cagiano, Giuseppina Campisi, Corrado Rubini, Silvana Papagerakis, Gaetano De Rosa, Maria Lina Tornesello, Franco M Buonaguro, Stefania Staibano, Pantaleo Bufo
BACKGROUND: Recent emerging evidences identify Human Papillomavirus (HPV) related Head and Neck squamous cell carcinomas (HN-SCCs) as a separate subgroup among Head and Neck Cancers with different epidemiology, histopathological characteristics, therapeutic response to chemo-radiation treatment and clinical outcome. However, there is not a worldwide consensus on the methods to be used in clinical practice. The endpoint of this study was to demonstrate the reliability of a triple method which combines evaluation of: 1...
2012: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/21189382/second-primary-cancers-after-an-index-head-and-neck-cancer-subsite-specific-trends-in-the-era-of-human-papillomavirus-associated-oropharyngeal-cancer
#11
Luc G T Morris, Andrew G Sikora, Snehal G Patel, Richard B Hayes, Ian Ganly
PURPOSE: Patients with head and neck squamous cell carcinoma (HNSCC) are at elevated risk of second primary malignancies (SPM), most commonly of the head and neck (HN), lung, and esophagus. Our objectives were to identify HNSCC subsite-specific differences in SPM risk and distribution and to describe trends in risk over 3 decades, before and during the era of human papillomavirus (HPV) -associated oropharyngeal SCC. METHODS: Population-based cohort study of 75,087 patients with HNSCC in the Surveillance, Epidemiology, and End Results (SEER) program...
February 20, 2011: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/18278468/screening-for-novel-binding-proteins-interacting-with-human-papillomavirus-type-18-e6-oncogene-in-the-hela-cdna-library-by-yeast-two-hybrid-system
#12
Shuang Li, Ping Liu, Ling Xi, Xuefeng Jiang, Jianfeng Zhou, Shixuan Wang, Li Meng, Yunping Lu, Ding Ma
To screen for novel binding proteins interacting with high-risk HPV 18 E6 oncogene, the strain AH109 was transformed with pGBKT7-HPV18 E6 plasmid, and subsequent transference was utilized to screen for interacting proteins with HPV 18 E6 in human Hela cDNA library. HPV18 E6 mRNA was expressed in yeast and there was no self-activation and toxicity in AH109. Seven proteins that interacted with HPV18 E6, including transmembrane protein 87B, phosphonoformate immuno-associated protein 5, vimentin, KM-HN-1 protein, dedicator of cytokinesis 7, vaccinia related kinase 2 and a hypothetical protein, were identified...
February 2008: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/17342339/molecular-analyses-and-prognostic-relevance-of-hpv-in-head-and-neck-tumours
#13
Gianna Badaracco, Consuelo Rizzo, Barbara Mafera, Barbara Pichi, Diana Giannarelli, Siavash S Rahimi, Maurizio G Vigili, Aldo Venuti
HPV involvement in head and neck (HN) cancer is still under active investigation. Fresh frozen and archival clinical samples from 115 patients affected by HN carcinomas were analysed by PCR-based methods and direct sequencing. HPV types, intra-type variants, physical status, viral load and viral transcript presence were determined. HPV positivity was correlated with the main clinical-pathological features, including smoker and drinker status, and the clinical outcome. Twenty-one tumours were HPV positive (18...
April 2007: Oncology Reports
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