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https://www.readbyqxmd.com/read/27900002/therapeutic-targeting-of-liver-cancer-with-a-recombinant-dna-vaccine-containing-the-hemagglutinin-neuraminidase-gene-of-newcastle-disease-virus-via-apoptotic-dependent-pathways
#1
Li-Gang Chen, Yuan-Sheng Liu, Tang-Hui Zheng, Xu Chen, Ping Li, Chuan-Xing Xiao, Jian-Lin Ren
A total of ~38.6 million mortalities occur due to liver cancer annually, worldwide. Although a variety of therapeutic methods are available, the efficacy of treatment at present is extremely limited due to an increased risk of malignancy and inherently poor prognosis of liver cancer. Gene therapy is considered a promising option, and has shown notable potential for the comprehensive therapy of liver cancer, in keeping with advances that have been made in the development of cancer molecular biology. The present study aimed to investigate the synergistic effects of the abilities of the hemagglutinin neuraminidase protein of Newcastle disease virus (NDV), the pro-apoptotic factor apoptin from chicken anaemia virus, and the interferon-γ inducer interleukin-18 (IL-18) in antagonizing liver cancer...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27886571/apigenin-inhibited-hypoxia-induced-stem-cell-marker-expression-in-a-head-and-neck-squamous-cell-carcinoma-cell-line
#2
Yuwaporn Ketkaew, Thanaphum Osathanon, Prasit Pavasant, Sireerat Sooampon
OBJECTIVE: Cancer stem cells contribute to tumor recurrence, and a hypoxic environment is critical for maintaining cancer stem cells. Apigenin is a natural product with anticancer activity. However, the effect of apigenin on cancer stem cells remains unclear. Our aim was to investigate the effect of apigenin on cancer stem cell marker expression in head and neck squamous cell carcinoma cells under hypoxia. DESIGN: We used three head and neck squamous cell carcinoma cell lines; HN-8, HN-30, and HSC-3...
November 15, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/27863568/molecular-imaging-and-precision-medicine-in-head-and-neck-cancer
#3
REVIEW
Esther Mena, Shwetha Thippsandra, Anusha Yanamadala, Siddaling Redy, Puskar Pattanayak, Rathan M Subramaniam
The concept of using tumor genomic profiling information has revolutionized personalized cancer treatment. Head and neck (HN) cancer management is being influenced by recent discoveries of activating mutations in epidermal growth factor receptor and related targeted therapies with tyrosine kinase inhibitors, targeted therapies for Kristen Rat Sarcoma, and MET proto-oncogenes. Molecular imaging using PET plays an important role in assessing the biologic behavior of HN cancer with the goal of delivering individualized cancer treatment...
January 2017: PET Clinics
https://www.readbyqxmd.com/read/27814768/impact-of-3t-multiparametric-mri-and-fdg-pet-ct-in-the-evaluation-of-occult-primary-cancer-with-cervical-node-metastasis
#4
Mária Gődény, Zsolt Lengyel, Gábor Polony, Zoltán Takácsi Nagy, Gergely Léránt, Orsolya Zámbó, Éva Remenár, László Tamás, Miklós Kásler
BACKGROUND: This study aimed to determine the ability of multimodal evaluation with multiparametric 3T-MRI (MPMRI) and positron emission tomography - computed tomography (PET/CT) to detect cancer of unknown primary origin (CUP) with neck lymph node (LN) metastasis. METHODS: The study group comprised 38 retrospectively analysed consecutive patients with LN metastasis in the head and neck (HN) region without known primary tumours (PTs). Statistical values of 3T-MRI and of FDG-PET/CT scans were evaluated...
November 4, 2016: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/27798871/radiotherapy-associated-furin-expression-and-tumor-invasiveness-in-recurrent-laryngeal-cancer
#5
Myungjin Lee, Chang Hwan Ryu, Hyo Won Chang, Gui Chul Kim, Seong Who Kim, Sang Yoon Kim
BACKGROUND/AIM: Recurrent laryngeal cancer often shows an aggressive phenotype after radiotherapy and does not respond to conventional therapeutic strategies. In this study, we investigated the contribution of furin to cellular invasiveness in radio-resistant laryngeal cancer. MATERIALS AND METHODS: Using previously established AMC-HN-3 and AMC-HN-8 cell lines from laryngeal carcinoma patients, recurrent laryngeal cancer models were generated by cumulative irradiation (AMC-HN-3-70Gy and AMC-HN-8-70Gy)...
October 2016: Anticancer Research
https://www.readbyqxmd.com/read/27793047/attenuation-of-cancer-initiating-cells-stemness-properties-by-abrogating-s100a4-calcium-binding-ability-in-head-and-neck-cancers
#6
Li-Hao Cheng, Kai-Feng Hung, Tung-Fu Huang, Hsin-Pei Hsieh, Shu-Ying Wang, Chih-Yang Huang, Jeng-Fan Lo
S100A4 is a calcium-binding protein capable of promoting epithelial-mesenchymal transition. Previously, we have demonstrated that S100A4 is required to sustain the head and neck cancer-initiating cells (HN-CICs) subpopulation. In this study, to further investigate the molecular mechanism, we established the head and neck squamous cell carcinoma (HNSCC) cell lines stably expressing mutant S100A4 proteins with defective calcium-binding sites on either N-terminal (NM) or C-terminal (CM), or a deletion of the last 15 amino-acid residues (CD)...
October 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27782691/technical-note-scuda-a-software-platform-for-cumulative-dose-assessment
#7
Seyoun Park, Todd McNutt, William Plishker, Harry Quon, John Wong, Raj Shekhar, Junghoon Lee
PURPOSE: Accurate tracking of anatomical changes and computation of actually delivered dose to the patient are critical for successful adaptive radiation therapy (ART). Additionally, efficient data management and fast processing are practically important for the adoption in clinic as ART involves a large amount of image and treatment data. The purpose of this study was to develop an accurate and efficient Software platform for CUmulative Dose Assessment (scuda) that can be seamlessly integrated into the clinical workflow...
October 2016: Medical Physics
https://www.readbyqxmd.com/read/27727066/quality-of-life-and-performance-status-from-a-substudy-conducted-within-a-prospective-phase-3-randomized-trial-of-concurrent-accelerated-radiation-plus-cisplatin-with-or-without-cetuximab-for-locally-advanced-head-and-neck-carcinoma-nrg-oncology-radiation-therapy
#8
Minh Tam Truong, Qiang Zhang, David I Rosenthal, Marcie List, Rita Axelrod, Eric Sherman, Randal Weber, Phuc Felix Nguyen-Tân, Adel El-Naggar, André Konski, James Galvin, David Schwartz, Andy Trotti, Craig Silverman, Anurag Singh, Karen Godette, James A Bonner, Christopher U Jones, Adam S Garden, George Shenouda, Chance Matthiesen, Quynh-Thu Le, Deborah Bruner
PURPOSE: To analyze the quality of life (QOL) and performance status (PS) (secondary outcome) in patients with stage III to IV head and neck cancer (HNC) enrolled on a prospective randomized phase 3 trial comparing radiation-cisplatin without cetuximab (CIS) or with cetuximab (CET/CIS). The QOL hypothesis proposed a between-arm difference in Functional Assessment of Cancer Therapy-Head and Neck (FACT-HN) total score of ≥10% of the instrument range from baseline to 1 year. METHODS AND MATERIALS: Patients who gave consent to the QOL/PS study completed the FACT-HN, Performance Status Scale for HNC (PSS-HN), and EuroQol (EQ-5D) at baseline through to 5 years...
August 12, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27727063/quality-of-life-and-performance-status-from-a-substudy-conducted-within-a-prospective-phase-3-randomized-trial-of-concurrent-standard-radiation-versus-accelerated-radiation-plus-cisplatin-for-locally-advanced-head-and-neck-carcinoma-nrg-oncology-rtog-0129
#9
Canhua Xiao, Qiang Zhang, Phuc Felix Nguyen-Tân, Marcie List, Randal S Weber, K Kian Ang, David Rosenthal, Edith J Filion, Harold Kim, Craig Silverman, Adam Raben, Thomas Galloway, Andre Fortin, Elizabeth Gore, Eric Winquist, Christopher U Jones, William Robinson, David Raben, Quynh-Thu Le, Deborah Bruner
PURPOSE/OBJECTIVE(S): To analyze quality of life (QOL) and performance status (PS) for head and neck cancer (HNC) patients treated on NRG Oncology RTOG 0129 by treatment (secondary outcome) and p16 status, and to examine the association between QOL/PS and survival. METHODS AND MATERIALS: Eligible patients were randomized into either an accelerated-fractionation arm or a standard-fractionation arm, and completed the Performance Status Scale for the Head and Neck (PSS-HN), the Head and Neck Radiotherapy Questionnaire (HNRQ), and the Spitzer Quality of Life Index (SQLI) at 8 time points from before treatment to 5 years after treatment...
July 25, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27644669/association-of-poly-adp-ribose-polymerase-1-variants-with-oral-squamous-cell-carcinoma-susceptibility-in-a-south-indian-population
#10
Sukumaran Anil, P B Gopikrishnan, Ashik Bin Basheer, B G Vidyullatha, Yahya A Alogaibi, Elna P Chalisserry, Fawad Javed, M Hn Dalati, Sajith Vellappally, Mohamed Ibrahim Hashem, Darshan Devang Divakar
BACKGROUND: Oral cancers account for approximately 2% of all cancers diagnosed each year; however, the vast majority (80%) of the affected individuals are smokers whose risk of developing a lesion is five to nine times greater than that of non-smokers. Tobacco smoke contains numerous carcinogens that cause DNA damage, including oxidative lesions that are removed effectively by the base-excision repair (BER) pathway, in which poly (ADP-ribose) polymerase 1 (PARP-1), plays key roles. Genetic variations in the genes encoding DNA repair enzymes may alter their functions...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27636187/a-retrospective-analysis-of-the-role-of-adjuvant-radiotherapy-in-the-treatment-of-cutaneous-melanoma
#11
Aaron Baker, Fabian Camacho, Genevieve Andrews, Heath Mackley
Melanoma is a significant clinical problem, with rising rates of incidence. Surgery is the mainstay of treatment. The role of adjuvant radiotherapy in the control of locoregionally advanced cutaneous melanoma is controversial. A retrospective study of the Surveillance, Epidemiology, and End Results (SEER) database was performed. Patients with locoregionally confined cutaneous melanoma treated surgically between 2004 and 2009 were evaluated, with cancer-specific and all-cause mortality as primary end points...
August 15, 2016: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/27598385/incremental-value-of-a-dedicated-head-and-neck-acquisition-during-18f-fdg-pet-ct-in-patients-with-differentiated-thyroid-cancer
#12
Renaud Ciappuccini, Nicolas Aide, David Blanchard, Jean-Pierre Rame, Dominique de Raucourt, Jean-Jacques Michels, Emmanuel Babin, Stéphane Bardet
OBJECTIVES: 18F-FDG-PET/CT is a useful tool used to evidence persistent/recurrent disease (PRD) in patients with differentiated thyroid cancer and iodine-refractory lesions. The aim of this study was to compare the diagnostic value at the cervical level of the routine whole-body (WB) acquisition and that of a complementary head and neck (HN) acquisition, performed successively during the same PET/CT study. METHODS: PET/CT studies combining WB and HN acquisitions performed in 85 consecutive patients were retrospectively reviewed by two nuclear medicine physicians...
2016: PloS One
https://www.readbyqxmd.com/read/27588136/photosensitizer-effect-of-9-hydroxypheophorbide-%C3%AE-on-diode-laser-irradiated-laryngeal-cancer-cells-oxidative-stress-directed-cell-death-and-migration-suppression
#13
Peijie He, Shen Bo, Phil-Sang Chung, Jin-Chul Ahn, Liang Zhou
The present study aimed to investigate the effect, and elucidate the potential mechanisms, of 9-hydroxypheophorbide α-based photodynamic therapy (9-HPbD-PDT) on apoptosis and necrosis induction, and migration suppression of laryngeal cancer AMC-HN-3 (HN-3) cells. Phototoxicity initiated by 9-HPbD-PDT on HN-3 cells was observed in a photosensitizer dose-dependent pattern. There was an initial increase of apoptotic cells coupled with gradual enhancement of reactive oxygen series (ROS) generation at lower doses of 9-HPbD...
September 2016: Oncology Letters
https://www.readbyqxmd.com/read/27575972/human-papillomavirus-as-a-favorable-prognostic-factor-in-a-subset-of-head-and-neck-squamous-cell-carcinomas-a-meta-analysis
#14
Hongwei Liu, Jintao Li, Yubai Zhou, Qin Hu, Yi Zeng, Mohammadzad Mehryar Mohammadreza
Many epidemical and biological studies have proposed that human papillomavirus (HPV), primarily high-risk HPV16/18, is an etiological factor for a subset of head and neck (HN) cancers. On that premise, we systematically reviewed relevant articles and improved the understanding of HPV-related cancers. This article comprehensively described the characteristics of HPV-associated HN tumors according to demography, histopathology, molecular biology, and prognosis. Meta-analyses were conducted to combine the studies that reported the association between HPV status and these variables using Rev Man 5...
August 30, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27568405/-anatomical-consideration-for-the-technique-of-nerve-sparing-during-radical-hysterectomy-for-cervical-cancer
#15
V Balaya, C Ngo, L Rossi, C Cornou, C Bensaid, R Douard, A S Bats, F Lecuru
Radical hysterectomy (RH) is an effective treatment for early-stage cervical cancer IA2 to IIA1 but RH is often associated with several significant complications such as urinary, anorectal and sexual dysfunction due to pelvic nerve injuries. Pelvic autonomic nerves including the superior hypogastric plexus (SHP), hypogastric nerves (HN), pelvic splanchnic nerves (PSN), sacral splanchnic nerves (SSN), inferior hypogastric plexus (IHP) and efferent branches of the IHP. We aimed to precise the neuroanatomy of the female pelvis in order to provide key-points of surgical anatomy to improve NSRH for cervical cancer...
September 2016: Gynécologie, Obstétrique & Fertilité
https://www.readbyqxmd.com/read/27564246/dynamic-imaging-grade-of-swallowing-toxicity-digest-scale-development-and-validation
#16
Katherine A Hutcheson, Martha P Barrow, Denise A Barringer, Jodi K Knott, Heather Y Lin, Randal S Weber, Clifton D Fuller, Stephen Y Lai, Clare P Alvarez, Janhavi Raut, Cathy L Lazarus, Annette May, Joanne Patterson, Justin W G Roe, Heather M Starmer, Jan S Lewin
BACKGROUND: The National Cancer Institute's Common Terminology Criteria for Adverse Events (CTCAE) is the universal framework for toxicity reporting in oncology trials. The objective of this study was to develop a CTCAE-compatible modified barium swallow (MBS) grade for the purpose of grading pharyngeal dysphagia as a toxicity endpoint in cooperative-group organ-preservation trials for head and neck cancer (HNC). It was hypothesized that a 5-point, CTCAE-compatible MBS grade (Dynamic Imaging Grade of Swallowing Toxicity [DIGEST]) based on the interaction of pharyngeal residue and laryngeal penetration/aspiration ratings would be feasible and psychometrically sound...
August 26, 2016: Cancer
https://www.readbyqxmd.com/read/27533851/polymorphisms-in-slco1b1-and-ugt1a1-are-associated-with-sorafenib-induced-toxicity
#17
Sander Bins, Anne Lenting, Samira El Bouazzaoui, Leni van Doorn, Esther Oomen-de Hoop, Ferry Alm Eskens, Ron Hn van Schaik, Ron Hj Mathijssen
AIM: Sorafenib-treated patients display a substantial variation in the incidence of toxicity. We aimed to investigate the association of genetic polymorphisms with observed toxicity on sorafenib. PATIENTS & METHODS: We genotyped 114 patients that were treated with sorafenib at the Erasmus MC Cancer Institute, the Netherlands, for SLCO1B1, SLCO1B3, ABCC2, ABCG2, UGT1A1 and UGT1A9. RESULTS: The UGT1A1 (rs8175347) polymorphism was associated with hyperbilirubinemia and treatment interruption...
September 2016: Pharmacogenomics
https://www.readbyqxmd.com/read/27520279/investigation-of-a-real-time-epid-based-patient-dose-monitoring-safety-system-using-site-specific-control-limits
#18
Todsaporn Fuangrod, Peter B Greer, Henry C Woodruff, John Simpson, Shashank Bhatia, Benjamin Zwan, Timothy A vanBeek, Boyd M C McCurdy, Richard H Middleton
PURPOSE: The aim of this study is to investigate the performance and limitations of a real-time transit electronic portal imaging device (EPID) dosimetry system for error detection during dynamic intensity modulated radiation therapy (IMRT) treatment delivery. Sites studied are prostate, head and neck (HN), and rectal cancer treatments. METHODS: The system compares measured cumulative transit EPID image frames with predicted cumulative image frames in real-time during treatment using a χ comparison with 4 %, 4 mm criteria...
2016: Radiation Oncology
https://www.readbyqxmd.com/read/27456663/hybrid-benzoxazole-coumarin-compounds-induce-death-receptor-mediated-switchable-apoptotic-and-necroptotic-cell-death-on-hn-5-head-and-neck-cancer-cell-line
#19
Sahar Yaghmaei, Parichehr Ghalayani, Siamak Salami, Farahnaz Nourmohammadian, Soheila Kohestanimobarhan, Vahideh Imeni
BACKGROUND: Efficacy of multimodality approaches to the treatment of squamous cell cancer of the head and neck has remained unsatisfactory and further advances are critically required. Targeted cell death induction is a novel therapeutic approach that may help to improve clinical management of Head and Neck cancer patients. OBJECTIVE: The potency of novel hybrid benzoxazole-coumarins on the induction of apoptotic and/or necroptotic cell death were evaluated in a Head and Neck carcinoma cell line, HN-5, and a human skin cell line, AGO1522...
July 25, 2016: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27453414/high-preoperative-and-postoperative-levels-of-carcinoembryonic-antigen-and-cyfra-21-1-indicate-poor-prognosis-in-patients-with-pathological-stage-i-nonsmall-cell-lung-cancer
#20
X Duan, Y Cui, H Li, G Shi, B Wu, M Liu, D Chang, T Wang, Y Kong
BACKGROUND: Serum carcinoembryonic antigen (CEA) and the soluble fragment of cytokeratin 19 (CYFRA 21-1) are supposed to have a prognostic role in patients with nonsmall cell lung cancer (NSCLC) after surgery, but it has not been used as an adjunct to the tumor-node-metastasis (TNM) staging system to provide therapy options for patients with pathological Stage I NSCLC. This study was designed to investigate the effect of serum levels of CEA and CYFRA 21-1 before and after surgery on the prognosis of patients with Stage I NSCLC...
December 2015: Indian Journal of Cancer
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