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https://www.readbyqxmd.com/read/28644692/hyperbaric-oxygen-may-only-be-optional-in-head-and-neck-necrotizing-fasciitis-a-retrospective-analysis-of-43-cases-and-review-of-the-literature
#1
Jens Faunø Thrane, Arunas Pikelis, Therese Ovesen
BACKGROUND: Necrotizing fasciitis in the head and neck (NF-HN) is a rare and potentially life-threatening condition. The use of hyperbaric oxygen therapy (HBOT) in the acute regimen is disputed and there is a lack of evidence of therapeutic effect. This study aims to describe a retrospective cohort of patients with NF-HN and investigate the use of HBOT and consequences thereof. METHODS: All patients treated for NF-HN at Aarhus University Hospital (AUH) between 2002 and 2014 were included in this retrospective cohort...
June 23, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28629955/correlation-study-between-dki-and-conventional-dwi-in-brain-and-head-and-neck-tumors
#2
Silvia Minosse, Simona Marzi, Francesca Piludu, Antonello Vidiri
PURPOSE: To investigate the relationship between the Diffusion Kurtosis Imaging (DKI) parameters and conventional metrics provided by Diffusion-weighted imaging (DWI) in patients affected by Brain or Head and Neck (HN) cancer. METHODS: Ten patients affected by brain tumor and nine patients with HN tumor underwent a pre-treatment MR examination at 3 T. The largest tumor section was manually contoured by two expert neuroradiologists. The apparent diffusion coefficient (Dapp) and apparent diffusional kurtosis (Kapp) parameters were determined at the voxel level by using the DKI model, and compared to the apparent diffusion coefficient (ADC) and the tissue diffusion coefficient (Dmono) obtained from mono-exponential fitting methods...
June 16, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28619289/validation-of-a-method-for-dose-of-the-day-calculation-in-head-neck-tomotherapy-by-using-planning-ct-to-mvct-deformable-image-registration
#3
M Branchini, C Fiorino, I Dell'Oca, M L Belli, L Perna, N Di Muzio, R Calandrino, S Broggi
PURPOSE: The aim of this study was to test the feasibility and dosimetric accuracy of a method that employs planning CT-to-MVCT deformable image registration (DIR) for calculation of the daily dose for head and neck (HN) patients treated with Helical Tomotherapy (HT). METHODS: For each patient, the planning kVCT (CTplan) was deformably registered to the MVCT acquired at the 15th therapy session (MV15) with a B-Spline Free Form algorithm using Mattes mutual information (open-source software 3D Slicer), resulting in a deformed CT (CTdef)...
June 12, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28607603/photodynamic-treatment-of-oral-squamous-cell-carcinoma-cells-with-low-curcumin-concentrations
#4
Kim Beyer, Frangis Nikfarjam, Manuel Butting, Markus Meissner, Anke König, Ana Ramirez Bosca, Roland Kaufmann, Detlef Heidemann, August Bernd, Stefan Kippenberger, Nadja Zöller
Objective: Curcumin is known for its anti-oxidative, anti-inflammatory and anti-tumorigenic qualities at concentrations ranging from 3.7µg/ml to 55µg/ml. Therefore it is pre-destined for tumour therapy. Due to high oral doses that have to be administered and the low bioavailability of curcumin new therapy concepts have to be developed. One of these therapy concepts is the combination of low curcumin concentrations and UVA or visible light. Aim of our study was to investigate the influence of this treatment regime on oral squamous cell carcinoma cells...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28592535/newcastle-disease-virus-establishes-persistent-infection-in-tumor-cells-in-vitro-contribution-of-the-cleavage-site-of-fusion-protein-and-second-sialic-acid-binding-site-of-hemagglutinin-neuraminidase
#5
Udaya S Rangaswamy, Weijia Wang, Xing Cheng, Patrick McTamney, Danielle Carroll, Hong Jin
Newcastle Disease Virus (NDV) is an oncolytic virus being developed for the treatment of cancer. Following infection of an ovarian human cancer cell line (OVCAR3) with a recombinant low pathogenic NDV, persistent infection (PI) was established in a subset of tumor cells. PI cells exhibited resistance to superinfection with NDV, and an anti-viral state as demonstrated by upregulation of interferon and interferon induced genes such as Myxoma resistance gene 1 (Mx1) and Retinoic acid-inducing gene-I (RIG-I). Viruses released from PI cells induced higher cell to cell fusion following infection compared to the parental virus in two tumor cell lines tested, HT1080 and HeLa, and remained to be attenuated in chickens...
June 7, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28555375/overview-of-the-8th-edition-tnm-classification-for-head-and-neck-cancer
#6
REVIEW
Shao Hui Huang, Brian O'Sullivan
The main purpose of the TNM system is to provide an anatomic-based classification to adequately depict cancer prognosis. Accurate cancer staging is important for treatment selection and outcome prediction, research design, and cancer control activities. To maintain clinical relevance, periodical updates to TNM are necessary. The recently published 8th edition TNM classification institutes the following changes to the staging of head and neck (excluding thyroid cancer): new stage classifications [HPV-related oropharyngeal cancer (HPV+ OPC) and soft tissue sarcoma of the head and neck (HN-STS)] and modification of T and N categories [T and N categories for nasopharyngeal cancer (NPC), T categories for oral cavity squamous cell carcinomas (OSCC), N categories for non-viral related head and neck cancer and unknown primary (CUP), and T categories for head and neck cutaneous carcinoma]...
July 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28496478/study-of-crocin-radiotherapy-induced-cytotoxicity-and-apoptosis-in-the-head-and-neck-cancer-hn-5-cell-line
#7
Vahid Vazifedan, Seyed Hadi Mousavi, Javad Sargolzaei, Shokouhozaman Soleymanifard, Azar Fani Pakdel
Malignant tumors of head and neck carcinomas are the sixth most common type of cancer. Current systemic therapies for cancer show side effects in normal tissues and short-term efficacy due to drug resistance. Consequently, there is much interest in identifying new drugs for cancer treatment. Crocin (an active ingredient of saffron) has been shown to have cytotoxic effects on cancer cell lines. Chemo radiotherapy is the standard treatment for head and neck cancer. In the present study, the cytotoxic effects, inducing apoptosis and the radiation sensitivity of crocin were evaluated in the head and neck cancer cell line (HN-5)...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28478859/symptom-clusters-in-patients-with-nasopharyngeal-carcinoma-during-radiotherapy
#8
Wenli Xiao, Carmen W H Chan, Yuying Fan, Doris Y P Leung, Weixiong Xia, Yan He, Linquan Tang
PURPOSE: Despite the improvement in radiotherapy (RT) technology, patients with nasopharyngeal carcinoma (NPC) still suffer from numerous distressing symptoms simultaneously during RT. The purpose of the study was to investigate the symptom clusters experienced by NPC patients during RT. METHODS: First-treated Chinese NPC patients (n = 130) undergoing late-period RT (from week 4 till the end) were recruited for this cross-sectional study. They completed a sociodemographic and clinical data questionnaire, the Chinese version of the M...
June 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/28476712/prevalence-and-diagnostic-of-head-and-neck-cancer-in-pakistan
#9
Azeem Akhtar, Ijaz Hussain, Muhammad Talha, Muhammad Shakeel, Muhammad Faisal, Muhammad Ameen, Tajammal Hussain
Head and Neck (HN) cancer is the most frequently identified cancer across the globe and is considered as 8-10 % of all cancers in Southeast Asia. The social and cultural habits are the main cause of the remarkable increase in HN cancer in Pakistan. HN cancers are more prevalent in men as compared to women. The HN cancer in Pakistan is mainly attributed to discrete demographic profile, risk elements, eating patterns and family history. The foremost factors of risk are linked with cigarette smoking, alcoholic drinks and tobacco chewing like paan, gutka, etc...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28386836/prospective-assessment-of-oral-mucositis-and-its-impact-on-quality-of-life-and-patient-reported-outcomes-during-radiotherapy-for-head-and-neck-cancer
#10
Pierfrancesco Franco, Stefania Martini, Jacopo Di Muzio, Chiara Cavallin, Francesca Arcadipane, Monica Rampino, Oliviero Ostellino, Giancarlo Pecorari, Paolo Garzino Demo, Massimo Fasolis, Mario Airoldi, Umberto Ricardi
Oral mucositis (OM) is a common acute side effect during radiotherapy treatments for head and neck cancer (HNC), with a potential impact on patient's compliance to therapy, quality of life (QoL) and clinical outcomes. Its timely and appropriate management is of paramount importance. Several quantitative scoring scales are available to properly assess OM and its influence on patient-reported outcomes (PROs) and QoL. We prospectively assessed OM in a cohort of HNC patients submitted to radiation using the Oral Mucositis Assessment Scale (OMAS), while its impact on PROs and QoL was evaluated employing the Oral Mucositis Weekly Questionnaire-Head and Neck Cancer (OMWQ-HN) and the Functional Assessment of Cancer Therapy-Head and Neck Cancer (FACT-HN)...
May 2017: Medical Oncology
https://www.readbyqxmd.com/read/28370954/citrus-flavonoid-naringenin-reduces-mammary-tumor-cell-viability-adipose-mass-and-adipose-inflammation-in-obese-ovariectomized-mice
#11
Jia-Yu Ke, Taylor Banh, Yung-Hsuan Hsiao, Rachel M Cole, Shana R Straka, Lisa D Yee, Martha A Belury
SCOPE: Obesity-related metabolic dysregulation may be a link between obesity and postmenopausal breast cancer. Naringenin, a flavonoid abundant in grapefruits, displays beneficial effects on metabolic health and tumorigenesis. Here, we assessed the effects of naringenin on mammary tumor cell growth in vitro and in obese ovariectomized mice. METHODS AND RESULTS: Naringenin inhibited cell growth, increased phosphorylation of AMP-activated protein kinase (AMPK), down-regulated CyclinD1 expression, and induced cell death in E0771 mammary tumor cells...
March 30, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28358764/a-thirty-year-experience-with-head-and-neck-flap-reconstruction
#12
Alexander Haosi Sun, Xiaolu Xu, Clarence Takashi Sasaki, Stephan Ariyan, Derek Matthew Steinbacher
BACKGROUND: Head and neck (HN) defects after tumor extirpation can be challenging to repair. Historically, pedicled flaps were the mainstay for reconstruction, but recently, free tissue transfer has been preferred. This study compares patient characteristics and flap outcomes for HN defects over a 30-year period at the authors' institution. METHODS: Head and neck cancer patients receiving flap reconstruction from 1983 to 2013 were included. Records were reviewed for demographic and perioperative data...
March 29, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28353039/a-feasibility-and-efficacy-trial-of-a-hand-held-humidification-device-in-patients-undergoing-radiotherapy-for-head-and-neck-cancer
#13
Priyanka Ghosh, Ann A Lazar, William R Ryan, Sue S Yom
PURPOSE: This study aimed to evaluate the effects of warm-mist humidification during and after head and neck radiation therapy (HN RT) on quality of life (QOL), as measured by the M. D. Anderson Symptom Inventory-Head and Neck (MDASI-HN) HN score. A secondary aim was to compare QOL among compliers (≥60% of protocol-recommended usage) versus non-compliers. METHODS: Twenty patients self-administered a hand-held, self-sterilizing humidification device for a recommended time of at least 15 min twice daily for 12 weeks...
March 28, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28330331/identification-and-quantification-of-novel-rna-isoforms-in-horn-cancer-of-bos-indicus-by-comprehensive-rna-seq
#14
Subhash J Jakhesara, Prakash G Koringa, Neelam M Nathani, Chaitanya G Joshi
Horn cancer (HC) is a squamous cell carcinoma of horn, commonly observed in Bos indicus of the Asian countries. To elucidate the complexity of alternative splicing present in the HC, high-throughput sequencing and analysis of HC and matching horn normal (HN) tissue were carried out. A total of 535,067 and 849,077 reads were analysed after stringent quality filtering for HN and HC, respectively. Cufflinks pipeline for transcriptome analysis revealed 4786 novel splice isoforms comprising 2432 exclusively in HC, 2055 exclusively in HN and 298 in both the conditions...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28330108/identification-of-novel-snps-in-differentially-expressed-genes-and-its-association-with-horn-cancer-of-bos-indicus-bullocks-by-next-generation-sequencing
#15
P G Koringa, S J Jakhesara, D N Rank, C G Joshi
The use of polymorphic markers like SNPs promises to provide comprehensive tool for analysing genome and identifying genomic regions that contribute to cancer phenotype. Horn cancer is the most common cancer among Bos indicus animals. Increased expression of some genes due to polymorphisms increases risk of HC incidence. We successfully amplified 91 SNPs located in 69 genes in 52 samples, each of HC and HN. Equimolar concentration of amplicons from 69 PCR products of each sample was pooled and subjected to sequencing using Ion Torrent PGM...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28297352/improved-setup-and-positioning-accuracy-using-a-three-point-customized-cushion-mask-bite-block-immobilization-system-for-stereotactic-reirradiation-of-head-and-neck-cancer
#16
He Wang, Congjun Wang, Samuel Tung, Andrew Wilson Dimmitt, Pei Fong Wong, Mark A Edson, Adam S Garden, David I Rosenthal, Clifton D Fuller, Gary B Gunn, Vinita Takiar, Xin A Wang, Dershan Luo, James N Yang, Jennifer Wong, Jack Phan
The purpose of this study was to investigate the setup and positioning uncertainty of a custom cushion/mask/bite-block (CMB) immobilization system and determine PTV margin for image-guided head and neck stereotactic ablative radiotherapy (HN-SABR). We analyzed 105 treatment sessions among 21 patients treated with HN-SABR for recurrent head and neck cancers using a custom CMB immobilization system. Initial patient setup was performed using the ExacTrac infrared (IR) tracking system and initial setup errors were based on comparison of ExacTrac IR tracking system to corrected online ExacTrac X-rays images registered to treatment plans...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28291935/helical-tomotherapy-to-linac-plan-conversion-utilizing-raystation-fallback-planning
#17
Xin Zhang, Jose Penagaricano, Ganesh Narayanasamy, Peter Corry, TianXiao Liu, Maraboyina Sanjay, Nava Paudel, Steven Morrill
RaySearch RayStation Fallback (FB) planning module can generate an equivalent backup radiotherapy treatment plan facilitating treatment on other linear accelerators. FB plans were generated from the RayStation FB module by simulating the original plan target and organ at risk (OAR) dose distribution and delivered in various backup linear accelerators. In this study, helical tomotherapy (HT) backup plans used in Varian TrueBeam linear accelerator were generated with the RayStation FB module. About 30 patients, 10 with lung cancer, 10 with head and neck (HN) cancer, and 10 with prostate cancer, who were treated with HT, were included in this study...
January 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28266802/polydatin-inhibits-cell-proliferation-and-induces-apoptosis-in-laryngeal-cancer-and-hela-cells-via-suppression-of-the-pdgf-akt-signaling-pathway
#18
Haixia Li, Baoyuan Shi, Yanyun Li, Fengfang Yin
Polydatin (PD), a stilbene compound extracted from Polygonum cuspidatum, is suggested to possess anti-cancer activities, including inhibition of cell proliferation, cell cycle arrest, and induction of apoptosis. The platelet-derived growth factor (PDGF)/AKT signaling pathway plays complex roles in tumor suppression. However, the effect of PD on the PDGF/AKT signaling pathway in laryngeal cancer and HeLa cells has not been explored. MTT assay and flow cytometry showed that PD inhibited cell proliferation and induced apoptosis in Hep-2 and AMC-HN-8 cells...
March 7, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28265548/cytotoxic-and-apoptogenic-effects-of-bryonia-aspera-root-extract-against-hela-and-hn-5-cancer-cell-lines
#19
Solmaz Pourgonabadi, Mohammad Sadegh Amiri, Seyed Hadi Mousavi
OBJECTIVE: Bryonia aspera (Stev. ex Ledeb) is a plant that grows in northeast of Iran. In the present study, cytotoxic and apoptogenic properties of B. aspera root extract was determined against HN-5(head and neck squamous cell carcinoma) and Hela (cervix adenocarcinoma) cell lines. MATERIALS AND METHODS: HN-5 and Hela cell lines were cultured in DMEM medium and incubated with different concentrations of B. aspera root extract. Cell viability was quantitated by MTT assay and the optical absorbance was measured at 570 nm (620 nm as the reference) by an ELISA reader, in each experiment...
January 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28249651/symptom-burden-and-dysphagia-associated-with-osteoradionecrosis-in-long-term-oropharynx-cancer-survivors-a-cohort-analysis
#20
Angela T T Wong, Stephen Y Lai, G Brandon Gunn, Beth M Beadle, Clifton D Fuller, Martha P Barrow, Theresa M Hofstede, Mark S Chambers, Erich M Sturgis, Abdallah Sherif Radwan Mohamed, Jan S Lewin, Katherine A Hutcheson
OBJECTIVE: The purpose is to examine the relationship between mandibular osteoradionecrosis (ORN) and chronic dysphagia in long-term oropharynx cancer (OPC) survivors, and to determine the perceived symptom burden associated with ORN. MATERIALS AND METHODS: Medical records of 349 OPC patients treated with bilateral IMRT and systemic therapy were reviewed. ORN was graded using a published 4-point classification schema. Patients were considered to have chronic dysphagia if they had aspiration pneumonia, stricture or aspiration detected by fluoroscopy or endoscopy, and/or feeding tube dependence in long-term follow-up ⩾1year following radiotherapy...
March 2017: Oral Oncology
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