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https://www.readbyqxmd.com/read/28330331/identification-and-quantification-of-novel-rna-isoforms-in-horn-cancer-of-bos-indicus-by-comprehensive-rna-seq
#1
Subhash J Jakhesara, Prakash G Koringa, Neelam M Nathani, Chaitanya G Joshi
Horn cancer (HC) is a squamous cell carcinoma of horn, commonly observed in Bos indicus of the Asian countries. To elucidate the complexity of alternative splicing present in the HC, high-throughput sequencing and analysis of HC and matching horn normal (HN) tissue were carried out. A total of 535,067 and 849,077 reads were analysed after stringent quality filtering for HN and HC, respectively. Cufflinks pipeline for transcriptome analysis revealed 4786 novel splice isoforms comprising 2432 exclusively in HC, 2055 exclusively in HN and 298 in both the conditions...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28330108/identification-of-novel-snps-in-differentially-expressed-genes-and-its-association-with-horn-cancer-of-bos-indicus-bullocks-by-next-generation-sequencing
#2
P G Koringa, S J Jakhesara, D N Rank, C G Joshi
The use of polymorphic markers like SNPs promises to provide comprehensive tool for analysing genome and identifying genomic regions that contribute to cancer phenotype. Horn cancer is the most common cancer among Bos indicus animals. Increased expression of some genes due to polymorphisms increases risk of HC incidence. We successfully amplified 91 SNPs located in 69 genes in 52 samples, each of HC and HN. Equimolar concentration of amplicons from 69 PCR products of each sample was pooled and subjected to sequencing using Ion Torrent PGM...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28297352/improved-setup-and-positioning-accuracy-using-a-three-point-customized-cushion-mask-bite-block-immobilization-system-for-stereotactic-reirradiation-of-head-and-neck-cancer
#3
He Wang, Congjun Wang, Samuel Tung, Andrew Wilson Dimmitt, Pei Fong Wong, Mark A Edson, Adam S Garden, David I Rosenthal, Clifton D Fuller, Gary B Gunn, Vinita Takiar, Xin A Wang, Dershan Luo, James N Yang, Jennifer Wong, Jack Phan
The purpose of this study was to investigate the setup and positioning uncertainty of a custom cushion/mask/bite-block (CMB) immobilization system and determine PTV margin for image-guided head and neck stereotactic ablative radiotherapy (HN-SABR). We analyzed 105 treatment sessions among 21 patients treated with HN-SABR for recurrent head and neck cancers using a custom CMB immobilization system. Initial patient setup was performed using the ExacTrac infrared (IR) tracking system and initial setup errors were based on comparison of ExacTrac IR tracking system to corrected online ExacTrac X-rays images registered to treatment plans...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28291935/helical-tomotherapy-to-linac-plan-conversion-utilizing-raystation-fallback-planning
#4
Xin Zhang, Jose Penagaricano, Ganesh Narayanasamy, Peter Corry, TianXiao Liu, Maraboyina Sanjay, Nava Paudel, Steven Morrill
RaySearch RayStation Fallback (FB) planning module can generate an equivalent backup radiotherapy treatment plan facilitating treatment on other linear accelerators. FB plans were generated from the RayStation FB module by simulating the original plan target and organ at risk (OAR) dose distribution and delivered in various backup linear accelerators. In this study, helical tomotherapy (HT) backup plans used in Varian TrueBeam linear accelerator were generated with the RayStation FB module. About 30 patients, 10 with lung cancer, 10 with head and neck (HN) cancer, and 10 with prostate cancer, who were treated with HT, were included in this study...
January 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28266802/polydatin-inhibits-cell-proliferation-and-induces-apoptosis-in-laryngeal-cancer-and-hela-cells-via-suppression-of-the-pdgf-akt-signaling-pathway
#5
Haixia Li, Baoyuan Shi, Yanyun Li, Fengfang Yin
Polydatin (PD), a stilbene compound extracted from Polygonum cuspidatum, is suggested to possess anti-cancer activities, including inhibition of cell proliferation, cell cycle arrest, and induction of apoptosis. The platelet-derived growth factor (PDGF)/AKT signaling pathway plays complex roles in tumor suppression. However, the effect of PD on the PDGF/AKT signaling pathway in laryngeal cancer and HeLa cells has not been explored. MTT assay and flow cytometry showed that PD inhibited cell proliferation and induced apoptosis in Hep-2 and AMC-HN-8 cells...
March 7, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28265548/cytotoxic-and-apoptogenic-effects-of-bryonia-aspera-root-extract-against-hela-and-hn-5-cancer-cell-lines
#6
Solmaz Pourgonabadi, Mohammad Sadegh Amiri, Seyed Hadi Mousavi
OBJECTIVE: Bryonia aspera (Stev. ex Ledeb) is a plant that grows in northeast of Iran. In the present study, cytotoxic and apoptogenic properties of B. aspera root extract was determined against HN-5(head and neck squamous cell carcinoma) and Hela (cervix adenocarcinoma) cell lines. MATERIALS AND METHODS: HN-5 and Hela cell lines were cultured in DMEM medium and incubated with different concentrations of B. aspera root extract. Cell viability was quantitated by MTT assay and the optical absorbance was measured at 570 nm (620 nm as the reference) by an ELISA reader, in each experiment...
January 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28249651/symptom-burden-and-dysphagia-associated-with-osteoradionecrosis-in-long-term-oropharynx-cancer-survivors-a-cohort-analysis
#7
Angela T T Wong, Stephen Y Lai, G Brandon Gunn, Beth M Beadle, Clifton D Fuller, Martha P Barrow, Theresa M Hofstede, Mark S Chambers, Erich M Sturgis, Abdallah Sherif Radwan Mohamed, Jan S Lewin, Katherine A Hutcheson
OBJECTIVE: The purpose is to examine the relationship between mandibular osteoradionecrosis (ORN) and chronic dysphagia in long-term oropharynx cancer (OPC) survivors, and to determine the perceived symptom burden associated with ORN. MATERIALS AND METHODS: Medical records of 349 OPC patients treated with bilateral IMRT and systemic therapy were reviewed. ORN was graded using a published 4-point classification schema. Patients were considered to have chronic dysphagia if they had aspiration pneumonia, stricture or aspiration detected by fluoroscopy or endoscopy, and/or feeding tube dependence in long-term follow-up ⩾1year following radiotherapy...
March 2017: Oral Oncology
https://www.readbyqxmd.com/read/28246479/clinical-impact-of-surveillance-for-head-and-neck-cancer-in-patients-with-esophageal-squamous-cell-carcinoma
#8
Hiroyuki Morimoto, Tomonori Yano, Yusuke Yoda, Yasuhiro Oono, Hiroaki Ikematsu, Ryuichi Hayashi, Atsushi Ohtsu, Kazuhiro Kaneko
AIM: To evaluate the clinical impact of surveillance for head and neck (HN) region with narrow band imaging (NBI) in patients with esophageal squamous cell carcinoma (ESCC). METHODS: Since 2006, we introduced the surveillance for HN region using NBI for all patients with ESCC before treatment, and each follow-up. The patients with newly diagnosed stage I to III ESCC were enrolled and classified into two groups as follows: Group A (no surveillance for HN region); between 1992 and 2000), and Group B (surveillance for HN region with NBI; between 2006 and 2008)...
February 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28192761/a-comparison-of-bayesian-and-non-linear-regression-methods-for-robust-estimation-of-pharmacokinetics-in-dce-mri-and-how-it-affects-cancer-diagnosis
#9
Nikolaos Dikaios, David Atkinson, Chiara Tudisca, Pierpaolo Purpura, Martin Forster, Hashim Ahmed, Timothy Beale, Mark Emberton, Shonit Punwani
The aim of this work is to compare Bayesian Inference for nonlinear models with commonly used traditional non-linear regression (NR) algorithms for estimating tracer kinetics in Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI). The algorithms are compared in terms of accuracy, and reproducibility under different initialization settings. Further it is investigated how a more robust estimation of tracer kinetics affects cancer diagnosis. The derived tracer kinetics from the Bayesian algorithm were validated against traditional NR algorithms (i...
February 5, 2017: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/28186838/biological-dose-escalated-definitive-radiation-therapy-in-head-and-neck-cancer
#10
Brigida Costa Ferreira, Pedro Sá-Couto, Leila Khouri, Maria do Carmo Lopes
OBJECTIVE: To compare treatment outcome of patients with head and neck (HN) tumours treated with definitive radiation therapy that, mainly owing to differences in the fractionation scheme used with simultaneous integrated boost techniques, resulted in a different biological dose. METHODS: 181 patients with HN cancer, prescribed to about 70.2 Gy in the primary tumour, were included in this study. Population cohort was divided into Group <70 and Group ≥70 when the mean dose converted to a 2 Gy fractionation in the primary tumour was less or higher than 70...
April 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28177210/noise-reduction-method-for-quantifying-nanoparticle-light-scattering-in-low-magnification-dark-field-microscope-far-field-images
#11
Dali Sun, Jia Fan, Chang Liu, Yang Liu, Yang Bu, Christopher J Lyon, Ye Hu
Nanoparticles have become a powerful tool for cell imaging and biomolecule, cell and protein interaction studies, but are difficult to rapidly and accurately measure in most assays. Dark-field microscope (DFM) image analysis approaches used to quantify nanoparticles require high-magnification near-field (HN) images that are labor intensive due to a requirement for manual image selection and focal adjustments needed when identifying and capturing new regions of interest. Low-magnification far-field (LF) DFM imagery is technically simpler to perform but cannot be used as an alternate to HN-DFM quantification, since it is highly sensitive to surface artifacts and debris that can easily mask nanoparticle signal...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28171708/a-multi-institutional-comparison-of-outcomes-of-immunosuppressed-and-immunocompetent-patients-treated-with-surgery-and-radiation-therapy-for-cutaneous-squamous-cell-carcinoma-of-the-head-and-neck
#12
Bindu V Manyam, Adam A Garsa, Rei-I Chin, Chandana A Reddy, Brian Gastman, Wade Thorstad, Sue S Yom, Brian Nussenbaum, Steven J Wang, Allison T Vidimos, Shlomo A Koyfman
BACKGROUND: Patients who are chronically immunosuppressed have higher rates of cutaneous squamous cell carcinoma of the head and neck (cSCC-HN). This is the largest multi-institutional study to date investigating the effect of immune status on disease outcomes in patients with cSCC-HN who underwent surgery and received postoperative radiation therapy (RT). METHODS: Patients from 3 institutions who underwent surgery and also received postoperative RT for primary or recurrent, stage I through IV cSCC-HN between 1995 and 2015 were included in this institutional review board-approved study...
February 7, 2017: Cancer
https://www.readbyqxmd.com/read/28156655/a-two-group-study-to-evaluate-the-impact-of-an-educational-handbook-in-the-care-of-patients-with-head-and-neck-cancer-hnc
#13
Areej El-Jawahri, Karen Quinn, Lisa Arcikowski, Gina Chan, Elene Viscosi, Carol Doherty, John Ross Clark, Jennifer S Temel, Lori J Wirth
228 Background: Patients undergoing chemoradiotherapy for HNC have a significant symptom burden, psychological distress, and educational needs. We evaluated the impact of an educational handbook integrated into oncology care on patient outcomes. METHODS: We conducted a two group, prospective, longitudinal study. Patients enrolled in group 1 received standard care as a control. Then, patients in group 2 received the intervention of a specialized handbook integrated into weekly visits with oncology clinicians during treatment...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156440/patient-reported-outcomes-pros-in-patients-with-human-papilloma-virus-hpv-positive-versus-negative-head-and-neck-cancer-hnc
#14
Areej El-Jawahri, Karen Quinn, Lisa Arcikowski, Gina Chan, Elene Viscosi, Carol Doherty, John Ross Clark, Lori J Wirth, Jennifer S Temel
87 Background: HNC caused by HPV has become an epidemic. Treatment for HNC results in a tremendous symptom burden. The impact of HPV-status on quality of life (QOL) and how this effects illness perception and mood has not been described. We sought to explore differences in PROs in patients with HPV + vs. - HNC. METHODS: This is a secondary analysis of data from a prospective, longitudinal intervention study of 60 patients with newly diagnosed HNC undergoing concurrent chemoradiation. 30 control patients received standard care followed by 30 intervention patients who received an educational intervention...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152942/communities-of-practice-a-jurisdictional-approach-to-improving-the-quality-of-care-in-radiation-medicine-in-ontario
#15
Michelle Ang, Lindsay Elizabeth Reddeman, Michael Sharpe, Margaret Hart, Carina Simniceanu, Stephen Breen, Joon-Hyung J Kim, Dani Scott, Khaled Zaza, David D'Souza, Michael F Milosevic, Stewart Gaede, Andrea Marshall, Brian P Yaremko, Katharina Sixel, Nicole Harnett, Eric Gutierrez, Padraig Richard Warde
122 Background: The Radiation Treatment Program (RTP) at Cancer Care Ontario (CCO) established several Communities of Practice (CoPs), with the goal of improving radiation treatment (RT) quality and safety. The RTP identifies variation in practice and quality improvement (QI) opportunities in the 14 Regional Cancer Centres (RCCs) and facilitates the development of CoPs to share best practices and standardize care. METHODS: Since 2010, the RTP has formed 7 CoPs ( > 185 members in total): 4 intra-disciplinary (Radiation Therapy, Medical Physics, Advanced Practice Radiation Therapy, Radiation Safety) and 3 inter-disciplinary (Head and Neck (HN), Gynecological (GYNE) and Lung Cancer)...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28111634/temporal-feature-extraction-from-dce-mri-to-identify-poorly-perfused-subvolumes-of-tumors-related-to-outcomes-of-radiation-therapy-in-head-and-neck-cancer
#16
Daekeun You, Madhava Aryal, Stuart E Samuels, Avraham Eisbruch, Yue Cao
This study aimed to develop an automated model to extract temporal features from DCE-MRI in head-and-neck (HN) cancers to localize significant tumor subvolumes having low blood volume (LBV) for predicting local and regional failure after chemoradiation therapy. Temporal features were extracted from time-intensity curves to build classification model for differentiating voxels with LBV from those with high BV. Support vector machine (SVM) classification was trained on the extracted features for voxel classification...
December 2016: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/28111039/-current-events-in-immunotherapy-for-upper-aerodigestive-tract-cancer
#17
Sophie Outh-Gauer, Christophe Le Tourneau, Chloé Broudin, Florian Scotte, Hélène Roussel, Stéphane Hans, Marion Mandavit, Eric Tartour, Cécile Badoual
Head and neck (HN) carcinomas (mostly represented by squamous cell carcinomas [SCC]) still have a poor prognosis, which could be dramatically improved with immunotherapy. Tumor's microenvironment changes, caused by many endogenous or exogenous events, can correlate with prognosis and therapeutic response. Here, we review recent data regarding HNSCC, nasopharyngeal carcinomas (NPC) and salivary gland malignant tumors, all three being potential target of immunotherapies. About half of HNSCC exhibit PD-L1 expression, this expression being upregulated in HPV-positive tumors...
February 2017: Annales de Pathologie
https://www.readbyqxmd.com/read/28101916/perceptions-of-cancer-of-unknown-primary-site-a-national-survey-of-australian-medical-oncologists
#18
Christos S Karapetis, Lisa Guccione, Martin Hn Tattersall, Helen Gooden, Claire M Vajdic, Sylvie Lambert, Monica Robotin, Linda Mileshkin, Penelope Schofield
INTRODUCTION: Despite being the 6(th) cause of cancer death in Australia, cancer of unknown primary (CUP) site remains poorly understood. AIMS: To describe practices relating to the diagnosis, investigation, classification, communication and management of CUP amongst medical oncologists. METHODS: We invited all members of the Medical Oncology Group of Australia to participate in a national, anonymous online survey about CUP. The survey collected data regarding diagnosis acceptance, diagnostic tests, treatment protocols and communication practices around the diagnosis of CUP...
January 19, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28070838/late-toxicity-evolving-radiotherapy-techniques-and-quality-of-life-in-nasopharyngeal-carcinoma
#19
Luciana Lastrucci, Silvia Bertocci, Vittorio Bini, Simona Borghesi, Roberta De Majo, Andrea Rampini, Paola Pernici, Pietro Giovanni Gennari
PURPOSE: To analyze quality of life (QoL) and functional state (FS) by patient-reported outcome (PRO) questionnaires (FACT-G, FACT-NP, PSS-HN, XeQOLS, and EQ-5D-3L) in long-term survivors nasopharyngeal carcinoma (NPC) treated with conventional radiotherapy (RT) and intensity modulated radiotherapy (IMRT). METHODS: 25 patients answered to five questionnaires about QoL and FS. All patients were assessed also for late toxicity. RESULTS: Functional Assessment of Cancer Therapy-General (FACT-G) and Performance Status Scale Head and Neck (PSS-HN) scores were significantly elevated (better QoL) in age <50 years (p = 0...
April 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28064445/a-panel-of-autoantibodies-against-multiple-tumor-associated-antigens-for-detecting-gastric-cancer
#20
Isamu Hoshino, Matsuo Nagata, Nobuhiro Takiguchi, Yoshihiro Nabeya, Atsushi Ikeda, Sana Yokoi, Akiko Kuwajima, Masatoshi Tagawa, Kazuyuki Matsushita, Yajima Satoshi, Shimada Hideaki
Gastric cancer is the second leading cause of cancer deaths in the world, and effective diagnosis is extremely important for good outcome. We assessed the diagnostic potential of an autoantibody panel that may provide a novel tool for the early detection of gastric cancer. We analyzed data from patients with gastric cancer and normal controls in a test and validation cohorts. Autoantibody levels were measured against a panel of six tumor-associated antigens [TAAs; p53, heat shock protein 70 (HSP70), HCC-22-5, peroxiredoxin VI (Prx VI), KM-HN-1, and p90 TAA (CYP2A)] via ELISA...
January 8, 2017: Cancer Science
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