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https://www.readbyqxmd.com/read/29914577/clinical-trials-for-treating-recurrent-head-and-neck-cancer-with-boron-neutron-capture-therapy-using-the-tsing-hua-open-pool-reactor
#1
REVIEW
Ling-Wei Wang, Yen-Wan Hsueh Liu, Fong-In Chou, Shiang-Huei Jiang
Head and neck (HN) cancer is an endemic disease in Taiwan, China. Locally recurrent HN cancer after full-dose irradiation poses a therapeutic challenge, and boron neutron capture therapy (BNCT) may be a solution that could provide durable local control with tolerable toxicity. The Tsing-Hua Open Pool Reactor (THOR) at National Tsing-Hua University in Hsin-Chu, provides a high-quality epithermal neutron source for basic and clinical BNCT research. Our first clinical trial, entitled "A phase I/II trial of boron neutron capture therapy for recurrent head and neck cancer at THOR", was carried out between 2010 and 2013...
June 19, 2018: Cancer communications
https://www.readbyqxmd.com/read/29903550/radiotherapy-utilization-and-fractionation-patterns-during-the-first-course-of-cancer-treatment-in-the-united-states-from-2004-to-2014
#2
Trevor J Royce, Muhammad M Qureshi, Minh Tam Truong
BACKGROUND: The changing use of radiation as a first-line cancer therapy in the United States is poorly characterized. This study aims to report radiotherapy utilization and fractionation patterns during the first course of cancer treatment. METHODS: We extracted all solid tumor cases from 2004 to 2014 in the National Cancer Data Base, which captures only the first course of treatment. Patients were subcategorized by disease site: breast, central nervous system (CNS), gastrointestinal, genitourinary, gynecologic, head and neck (HN), musculoskeletal, skin, or thoracic...
June 11, 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29878758/coadministration-of-irgd-with-multistage-responsive-nanoparticles-enhanced-tumor-targeting-and-penetration-abilities-for-breast-cancer-therapy
#3
Chuan Hu, Xiaotong Yang, Rui Liu, Shaobo Ruan, Yang Zhou, Wei Xiao, Wenqi Yu, Chuanyao Yang, Huile Gao
Limited tumor targeting and poor penetration of nanoparticles are two major obstacles to improving the outcome of tumor therapy. Herein, coadministration of tumor-homing peptide iRGD and multistage-responsive penetrating nanoparticles for the treatment of breast cancer are reported. This multistage-responsive nanoparticle, IDDHN, was comprised of NO donor-modified hyaluronic acid shell (HN) and small-sized dendrimer, namely Dendri-Graft-L-Lysine conjugated with doxorubicin and indocyanine (IDD). The results showed that IDDHN could be degraded rapidly from about 330 nm to a smaller size that was in a size range of 35 nm to 150 nm (most at 35~60 nm) after hyaluronidase (HAase) incubation for 4 hours, in vitro cellular uptake demonstrated that iRGD could mediate more endocytosis of IDDHN into 4T1 cells, which was attributed to the overexpression of αvβ3 integrin receptor...
June 7, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29868479/transoral-laser-microsurgery-for-supraglottic-cancer
#4
Petra Ambrosch, Mireia Gonzalez-Donate, Asita Fazel, Claudia Schmalz, Jürgen Hedderich
Introduction: Transoral laser microsurgery (TLM) is an accepted and effective treatment strategy for supraglottic carcinomas. Early supraglottic carcinoma has excellent outcomes independently of the treatment approach. The role of TLM for the treatment of locally advanced tumors is debated. Particularly, the functional outcomes after TLM have to be proven by functional assessment of large cohorts of patients. This study analyzes the oncologic and functional outcomes after TLM for supraglottic carcinomas...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29866335/quantifying-the-robustness-of-18-f-fdg-pet-ct-radiomic-features-with-respect-to-tumor-delineation-in-head-and-neck-and-pancreatic-cancer-patients
#5
Maria Luisa Belli, Martina Mori, Sara Broggi, Giovanni Mauro Cattaneo, Valentino Bettinardi, Italo Dell'Oca, Federico Fallanca, Paolo Passoni, Emilia Giovanna Vanoli, Riccardo Calandrino, Nadia Di Muzio, Maria Picchio, Claudio Fiorino
PURPOSE: To investigate the robustness of PET radiomic features (RF) against tumour delineation uncertainty in two clinically relevant situations. METHODS: Twenty-five head-and-neck (HN) and 25 pancreatic cancer patients previously treated with 18 F-Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT)-based planning optimization were considered. Seven FDG-based contours were delineated for tumour (T) and positive lymph nodes (N, for HN patients only) following manual (2 observers), semi-automatic (based on SUV maximum gradient: PET_Edge) and automatic (40%, 50%, 60%, 70% SUV_max thresholds) methods...
May 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29863801/androgen-receptor-in-salivary-gland-carcinoma-a-review-of-an-old-marker-as-a-possible-new-target
#6
Chit Cheng Yeoh, Nedal Dabab, Elyse Rigby, Ritu Chhikara, Iolia Akaev, Ricardo Santiago Gomez, Felipe Fonseca, Peter A Brennan, Siavash Rahimi
The role of the Androgen Receptor (AR) as an immunomarker for diagnosis of salivary gland duct carcinoma (SDC) is well known. Other non-squamous cell head and neck cancers (NSCC-HN), including a small subset of salivary gland cancers (SGCs), can also express AR. With the increase of effective and powerful new generation of anti-androgen agents and drugs administered orally, more targetable AR driven NSCC-HN, such as subsets of SGCs, should be investigated for possible expression of AR. In this review, we focus on SGC sub-types, which could express AR and describe the main androgen deprivation therapy (ADT) strategies...
June 4, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29785159/assessment-of-the-quality-of-life-and-performance-status-in-patients-with-oral-submucous-fibrosis-in-central-india
#7
Revant H Chole, Ranjitkumar Patil
Background and aims: Measuring quality of life in patients with oral submucous fibrosis is of utmost importance in assessing treatment outcomes. This study examined the impact of oral submucous fibrosis and its treatment on the quality of life and performance status of persons with oral submucous fibrosis. Methods: Quality of life was measured in patients with oral submucous fibrosis using the European Organization for Research and Treatment of Cancer Quality of Life head and neck 35 Questionnaire (EORTC QLQ-C35); performance status was measured by Performance Status Scale for Head and Neck Cancer Patients (PSS-HN), at four points in time: baseline, one month, two months and three months after start of treatment...
2018: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29765265/is-volumetric-modulated-arc-therapy-with-constant-dose-rate-a-valid-option-in-radiation-therapy-for-head-and-neck-cancer-patients
#8
Annamaria Didona, Valentina Lancellotta, Claudio Zucchetti, Bianca Moira Panizza, Alessandro Frattegiani, Martina Iacco, Anna Concetta Di Pilato, Simonetta Saldi, Cynthia Aristei
Background: Intensity-modulated radiotherapy (IMRT) improves dose distribution in head and neck (HN) radiation therapy. Volumetric-modulated arc therapy (VMAT), a new form of IMRT, delivers radiation in single or multiple arcs, varying dose rates (VDR-VMAT) and gantry speeds, has gained considerable attention. Constant dose rate VMAT (CDR-VMAT) associated with a fixed gantry speed does not require a dedicated linear accelerator like VDR-VMAT. The present study explored the feasibility, efficiency and delivery accuracy of CDR-VMAT, by comparing it with IMRT and VDR-VMAT in treatment planning for HN cancer...
May 2018: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/29721757/nmr-1-h-13-c-15-n-backbone-and-13-c-side-chain-resonance-assignment-of-the-g12c-mutant-of-human-k-ras-bound-to-gdp
#9
Alok K Sharma, Seung-Joo Lee, Alan C Rigby, Sharon A Townson
K-Ras is a key driver of oncogenesis, accounting for approximately 80% of Ras-driven human cancers. The small GTPase cycles between an inactive, GDP-bound and an active, GTP-bound state, regulated by guanine nucleotide exchange factors and GTPase activating proteins, respectively. Activated K-Ras regulates cell proliferation, differentiation and survival by signaling through several effector pathways, including Raf-MAPK. Oncogenic mutations that impair the GTPase activity of K-Ras result in a hyperactivated state, leading to uncontrolled cellular proliferation and tumorogenesis...
May 2, 2018: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/29691673/multi-panel-assay-of-serum-autoantibodies-in-colorectal-cancer
#10
Mitsunori Ushigome, Yoshihiro Nabeya, Hiroaki Soda, Nobuhiro Takiguchi, Akiko Kuwajima, Masatoshi Tagawa, Kazuyuki Matsushita, Junichi Koike, Kimihiko Funahashi, Hideaki Shimada
BACKGROUND: Although serum p53 autoantibodies (s-p53-Abs) are induced even in the early stages of colorectal cancer, their positive rate is only approximately 20%. Therefore, we assessed the possibility of using other serum autoantibodies to increase the positive rates for detecting colorectal cancer. METHODS: Autoantibodies against 17 tumor antigens (p53, RalA, HSP70, Galectin1, KM-HN-1, NY-ESO-1, p90, Sui1, HSP40, CyclinB1, HCC-22-5, c-myc, PrxVI, VEGF, HCA25a, p62, and Annexin II) were evaluated in 279 patients with colorectal cancer and 74 healthy controls...
April 24, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29653204/epha3-maintains-radioresistance-in-head-and-neck-cancers-through-epithelial-mesenchymal-transition
#11
Song Hee Kim, Won Hyeok Lee, Seong Who Kim, Hyoung Uk Je, Jong Cheol Lee, Hyo Won Chang, Young Min Kim, Kyungbin Kim, Sang Yoon Kim, Myung Woul Han
Radiotherapy is a well-established therapeutic modality used in the treatment of many cancers. However, radioresistance remains a serious obstacle to successful treatment. Radioresistance can cause local recurrence and distant metastases in some patients after radiation treatment. Thus, many studies have attempted to identify effective radiosensitizers. Eph receptor functions contribute to tumor development, modulating cell-cell adhesion, invasion, neo-angiogenesis, tumor growth and metastasis. However, the role of EphA3 in radioresistance remains unclear...
July 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29552148/suppression-of-jab1-expression-inhibits-proliferation-and-promotes-apoptosis-of-amc-hn-8-cells
#12
Pei-Hua Li, Lin Wang, Yao-Jie Pan, Miao-Miao Sang, Jun-Nian Zheng, Dong-Sheng Pei
c-Jun activation domain-binding protein-1 (Jab1) is a multifunctional protein involved in cell proliferation and apoptosis, DNA damage and repair and genome stability. In a number of types of human carcinoma, the abnormal expression of Jab1 is associated with poor prognosis, suggesting that Jab1 serves a vital function in tumorigenesis. However, the functional effects and the underlying molecular mechanisms of Jab1 in laryngeal squamous cell carcinoma (LSCC) progression remain poorly understood. The results of the present study demonstrate that downregulating Jab1 expression promotes LSCC apoptosis while inhibiting the proliferation of LSCC cells...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29547766/immunotherapy-in-head-and-neck-cancers-a-new-challenge-for-immunologists-pathologists-and-clinicians
#13
REVIEW
Sophie Outh-Gauer, Marie Alt, Christophe Le Tourneau, Jérémy Augustin, Chloé Broudin, Cassandre Gasne, Thomas Denize, Haitham Mirghani, Elizabeth Fabre, Madeleine Ménard, Florian Scotte, Eric Tartour, Cécile Badoual
Cancer occurrence can be understood as the result of dysfunctions in immune tumoral microenvironment. Here we review the recent understandings of those microenvironment changes, regarding their causes and prognostic significance in head and neck (HN) carcinoma. We will focus on HN squamous cell cancer (SCC) and nasopharyngeal carcinomas (NPC). Their overall poor prognosis may be improved with immunotherapy in a subset of patients, as supported by current clinical trials. However, finding reliable markers of therapeutic response is crucial for patient selection, due to potential severe adverse reactions and high costs...
April 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29516211/quantitative-assessment-of-fluorescence-intensity-of-icg-in-sentinel-nodes-in-early-gastric-cancer
#14
Keishi Okubo, Yoshikazu Uenosono, Takaaki Arigami, Daisuke Matsushita, Shigehiro Yanagita, Takashi Kijima, Masahiko Amatatsu, Sumiya Ishigami, Kosei Maemura, Shoji Natsugoe
BACKGROUND: The sentinel node (SN) detection by dual tracer method using indocyanine green (ICG) and a radioisotope (RI) has been recommended for early gastric cancer. However, institutions are limited due to radioactivity in the RI method. The greatest advantage of the RI method is that it objectively assesses RI uptake as a numerical value. The aim of the present study was to verify the usefulness of ICG fluorescence intensity in SN. METHODS: Seventeen patients with early gastric cancer were enrolled in this study...
March 7, 2018: Gastric Cancer
https://www.readbyqxmd.com/read/29513892/does-the-number-of-sentinel-lymph-nodes-removed-affect-the-false-negative-rate-for-head-and-neck-melanoma
#15
Charles J Puza, Srirama Josyula, Alicia M Terando, John H Howard, Doreen M Agnese, Paul J Mosca, Walter T Lee, Georgia M Beasley
BACKGROUND AND OBJECTIVES: Head and neck (HN) cutaneous melanoma is associated with worse disease-free survival compared to non-HN cutaneous melanoma, possibly due to inadequate staging. We aim to determine if a higher yield of sentinel lymph nodes (SLNs) affected rates of sentinel lymph node biopsy (SLNB) positivity. METHODS: Two Cancer Registries were used to identify patients who underwent SLNB for HN melanoma. A false negative (FN) was defined by nodal recurrence after negative SLNB...
March 7, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29506885/patient-side-appraisal-of-late-radiation-induced-oral-microvascular-changes
#16
Renée Helmers, Nina F Straat, Arash Navran, Tim A P Nai Chung Tong, David N Teguh, Robert A van Hulst, Jan de Lange, Dan M J Milstein
PURPOSE: To determine the clinical feasibility of examining and measuring late irradiation changes in the oral microcirculation of head and neck (HN) cancer patients using the novel CytoCam video microscope system. METHODS AND MATERIALS: In 30 HN cancer patients and 30 age-matched controls, bilateral video images were recorded noninvasively of the oral microcirculation of the buccal mucosa and mandibular gingiva. Tissue perfusion parameters, such as functional capillary density (FCD), buccal blood vessel diameter, and microcirculatory flow index, were analyzed...
January 31, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29504181/comparison-of-3-he-and-129-xe-mri-for-evaluation-of-lung-microstructure-and-ventilation-at-1-5t
#17
Neil J Stewart, Ho-Fung Chan, Paul J C Hughes, Felix C Horn, Graham Norquay, Madhwesha Rao, Denise P Yates, Rob H Ireland, Matthew Q Hatton, Bilal A Tahir, Paul Ford, Andrew J Swift, Rod Lawson, Helen Marshall, Guilhem J Collier, Jim M Wild
BACKGROUND: To support translational lung MRI research with hyperpolarized 129 Xe gas, comprehensive evaluation of derived quantitative lung function measures against established measures from 3 He MRI is required. Few comparative studies have been performed to date, only at 3T, and multisession repeatability of 129 Xe functional metrics have not been reported. PURPOSE/HYPOTHESIS: To compare hyperpolarized 129 Xe and 3 He MRI-derived quantitative metrics of lung ventilation and microstructure, and their repeatability, at 1...
March 5, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29484655/delineation-of-human-prostate-cancer-evolution-identifies-chromothripsis-as-a-polyclonal-event-and-fkbp4-as-a-potential-driver-of-castration-resistance
#18
Joël R Federer-Gsponer, Cristina Quintavalle, David C Müller, Tanja Dietsche, Valeria Perrina, Thomas Lorber, Darius Juskevicius, Elisabeth Lenkiewicz, Tobias Zellweger, Thomas Gasser, Michael T Barrett, Cyrill A Rentsch, Lukas Bubendorf, Christian Ruiz
Understanding the evolutionary mechanisms and genomic events leading to castration-resistant (CR) prostate cancer (PC) is key to improve the outcome of this otherwise deadly disease. Here, we delineated the tumour history of seven patients progressing to castration resistance by analysing matched prostate cancer tissues before and after castration. We performed genomic profiling of DNA content-based flow-sorted populations in order to define the different evolutionary patterns. In one patient, we discovered that a catastrophic genomic event, known as chromothripsis, resulted in multiple CRPC tumour populations with distinct, potentially advantageous copy number aberrations, including an amplification of FK506 binding protein 4 (FKBP4, also known as FKBP52), a protein enhancing the transcriptional activity of androgen receptor signalling...
May 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29481712/the-impact-of-adjuvant-chemoradiotherapy-timing-on-survival-of-head-and-neck-cancers
#19
Moses Tam, S Peter Wu, Naamit K Gerber, Anna Lee, David Schreiber, Babak Givi, Kenneth Hu
BACKGROUND: Delays in postoperative head and neck (HN) radiotherapy have been associated with decreased overall survival; however, the impact of delays in postoperative HN chemoradiotherapy remains undefined. METHODS: All patients with nonmetastatic HN cancer (oral cavity, oropharynx, larynx, hypopharynx) who underwent curative intent surgery and received adjuvant chemoradiotherapy were identified from the National Cancer Database (2005-2012). Overall treatment time (OTT) was defined as the time from surgery to the end of radiation therapy...
February 26, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29473248/posttraumatic-growth-in-head-and-neck-cancer-survivors-is-it-possible-and-what-are-the-correlates
#20
Linda Sharp, Devon Redfearn, Aileen Timmons, Myles Balfe, Joanne Patterson
OBJECTIVES: Posttraumatic growth (PTG) is a possible positive consequence of a traumatic event, such as cancer. Head and neck cancer (HNC) may be particularly traumatic, given its adverse effects on functional, psychological, and social wellbeing. We investigated the extent of PTG, factors associated with PTG, and associations between PTG and health-related quality-of-life (HRQoL) in HNC survivors. METHODS: HNC survivors (ICD10 C00-C14, C32), identified from the population-based National Cancer Registry Ireland, completed a postal survey...
February 23, 2018: Psycho-oncology
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