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https://www.readbyqxmd.com/read/29473248/post-traumatic-growth-in-head-and-neck-cancer-survivors-is-it-possible-and-what-are-the-correlates
#1
Linda Sharp, Devon Redfearn, Aileen Timmons, Myles Balfe, Joanne Patterson
OBJECTIVES: Posttraumatic growth (PTG) is a possible positive consequence of a traumatic event, such as cancer. Head and neck cancer (HNC) may be particularly traumatic, given its adverse effects on functional, psychological and social wellbeing. We investigated: extent of PTG; factors associated with PTG; and associations between PTG and health-related quality-of-life (HRQoL) in HNC survivors. METHODS: HNC survivors (ICD10 C00-C14, C32), identified from the population-based National Cancer Registry Ireland, completed a postal survey...
February 23, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29452869/three-dimensional-printer-aided-casting-of-soft-custom-silicone-boluses-scsbs-for-head-and-neck-radiation-therapy
#2
Tsuicheng Chiu, Jun Tan, Mathew Brenner, Xuejun Gu, Ming Yang, Kenneth Westover, Tobin Strom, David Sher, Steve Jiang, Bo Zhao
PURPOSE: Custom tissue compensators provide dosimetric advantages for treating superficial or complex anatomy, but currently available fabrication technology is expensive or impractical for most clinical operations and yields compensators that are difficult for patients to tolerate. We aimed to develop an inexpensive, clinically feasible workflow for generating patient-specific, soft, custom silicone boluses (SCSBs) for head-and-neck (HN) radiation therapy. METHODS AND MATERIALS: We developed a method using 3-dimensional printed parts for generating SCSBs for the treatment of HN cancers...
November 11, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29438228/antitumor-effect-of-the-newcastle-disease-viral-hemagglutinin-neuraminidase-gene-is-expressed-through-an-oncolytic-adenovirus-effect-in-osteosarcoma-cells
#3
Shuang Chen, Qinggao Zhang, Duo Xu, Yiquan Li, Yuanyuan Fan, Wenjie Li, Xunzhe Yin, Yang Zhang, Jingwei Liu, Xiao Li, Lili Sun, Ningyi Jin
Newcastle disease virus (NDV) can specifically kill cancer cells and has less toxicity to normal cells. The hemagglutinin-neuraminidase (HN) protein is an important structural protein in NDV pathogenesis and has been postulated as a promising candidate for antitumor therapy. The aim of this study was to investigate the anticancer potential of recombinant adenovirus Ad-HN-PEG3p-E1a. An MTS assay was performed to determine viral proliferation after viral infection, the data showed that the proliferation ability of osteosarcoma cells decreased, whereas there was no significant change in normal hepatic cells...
March 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29360397/practice-patterns-for-the-radical-treatment-of-nasopharyngeal-cancer-by-head-and-neck-oncologists-in-the-united-kingdom
#4
Imran Petkar, Shreerang Bhide, Kate Newbold, Kevin Harrington, Chris Nutting
OBJECTIVE: Advances in radiation delivery, imaging techniques, and chemotherapy have significantly improved treatment options for non-metastatic nasopharyngeal cancers (NPC). However, their impact on the practice in the United Kingdom (UK), where this tumour is rare, is unknown. This study examined the current attitudes of UK head and neck (HN) oncologists to the treatment of NPC. METHODS: UK HN oncologists representing 19/23 cancer networks were sent an invitation email with a personalised link to a web-based survey designed to identify the influence of tumour and nodal staging on current NPC management practices...
January 23, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29280495/tsr2-induces-laryngeal-cancer-cell-apoptosis-through-inhibiting-nf-%C3%AE%C2%BAb-signaling-pathway
#5
Hong-Jiang He, Han Bing, Guijun Liu
OBJECTIVES/HYPOTHESIS: Human laryngeal squamous cell carcinoma (LSCC) is a malignancy that was discovered originally in the epithelial tissue of laryngeal mucosa. However, the underlying molecular mechanism is still not clear. In this study, we aimed to investigate the potential molecular mechanisms of TSR2 in the LSCC cell apoptosis. STUDY DESIGN: The expression of TSR2 was first analyzed in LSCC tissues. Then functional effects of TSR2 on Hep-2 and AMC-HN-8 cell lines were performed by overexpression pcDNA3...
December 27, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29229507/patient-reported-dry-mouth-instrument-comparison-and-model-performance-for-correlation-with-quality-of-life-in-head-and-neck-cancer-survivors
#6
Mona Kamal, David I Rosenthal, Stefania Volpe, Ryan P Goepfert, Adam S Garden, Katherine A Hutcheson, Karine A Al Feghali, Mohamed Ahmed Mohamed Meheissen, Salman A Eraj, Amy E Dursteler, Bowman Williams, Joshua B Smith, Jeremy M Aymard, Joel Berends, Aubrey L White, Steven J Frank, William H Morrison, Richard Cardoso, Mark S Chambers, Erich M Sturgis, Tito R Mendoza, Charles Lu, Abdallah S R Mohamed, Clifton D Fuller, G Brandon Gunn
PURPOSE: To identify a clinically meaningful cut-point for the single item dry mouth question of the MD Anderson Symptom Inventory-Head and Neck module (MDASI-HN). METHODS: Head and neck cancer survivors who had received radiation therapy (RT) completed the MDASI-HN, the University of Michigan Hospital Xerostomia Questionnaire (XQ), and the health visual analog scale (VAS) of the EuroQol Five Dimension Questionnaire (EQ-5D). The Bayesian information criteria (BIC) were used to test the prediction power of each tool for EQ-5D VAS...
December 8, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29222577/occupational-prestige-trajectory-and-the-risk-of-lung-and-head-and-neck-cancer-among-men-and-women-in-france
#7
Gwenn Menvielle, Julien Dugas, Jeanna-Eve Franck, Matthieu Carton, Brigitte Trétarre, Isabelle Stücker, Danièle Luce
OBJECTIVES: This study aimed at investigating the associations between occupational prestige trajectories and lung and head and neck (HN) cancer risk and to assess to what extent smoking, alcohol drinking, and occupational exposures contribute to these associations. METHODS: Using data from the ICARE case-control study (controls (2676 men/715 women), lung cancers (2019 men/558 women), HN cancers (1793 men/305 women), we defined occupational prestige trajectories using group-based modeling of longitudinal data...
December 9, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/29186980/overexpressed-mir-128a-enhances-chemoradiotherapy-to-laryngeal-cancer-cells-and-its-correlation-with-bmi1
#8
Hui Chen, Lei Jin, Liang Zhou, Jia-Meng Huang
AIM: To clarify the function of miR-128a on radiotherapy and chemotherapy resistance in laryngeal cancer and explore the possible mechanism. MATERIALS & METHODS: Hep-2 and AMC-HN-8 cell lines were cultured. MiR-128a was upregulated utilizing lentiviral transfection. Through radiotherapy and chemotherapy assays, the function of miR-128a on chemoradiotherapy was evaluated. The correlation of miR-128a with BMI1 was identified by performing real-time PCR. RESULTS: The hsa-miR128a cell line was established...
November 30, 2017: Future Oncology
https://www.readbyqxmd.com/read/29174806/is-routine-holistic-assessment-with-a-prompt-list-feasible-during-consultations-after-treatment-for-oral-cancer
#9
S N Rogers, S Ahiaku, D Lowe
The head and neck cancer Patient Concerns Inventory (PCI-HN) is a holistic, self-reported list of items that can help patients to disclose their needs and concerns during routine follow-up consultations. The aim of this study was to report how often it was used during the first three years of follow up after treatment for oral cancer, and the range of issues that were raised. The sample comprised consecutive patients treated over a three-year period with curative intent. All clinic attendances were reviewed until October 2015 or until patients had a recurrence, a subsequent primary, metastases, or were discharged home or to follow up at a peripheral hospital, or started palliative care...
November 23, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29143362/microrna-26a-inhibits-proliferation-and-tumorigenesis-via-targeting-cks2-in-laryngeal-squamous-cell-carcinoma
#10
Zhiyan Wu, Baocai Lu, Xiao Li, Wenjie Miao, Jin Li, Yongjuan Shi, Wenfa Yu
Laryngeal squamous cell carcinoma (LSCC) is one of the most common head and neck cancer, with high mortality and incidence. MicroRNA-26a (miR-26a) is involved in the development and progression of several tumors. However, the roles of miR-26a and its target CKS2 in LSCC progression are not yet clear. The mRNA and protein expression was determined using RT-PCR and Western blotting assay, respectively. Cell proliferation was detected using a Cell Counting kit-8 assay (CCK-8). Transwell assay was used to evaluate cell migration and invasion...
November 16, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29114602/impact-on-quality-of-life-of-imrt-versus-3-d-conformal-radiation-therapy-in-head-and-neck-cancer-patients-a-case-control-study
#11
Edvard Abel, Ewa Silander, Jan Nyman, Mogens Bove, Leif Johansson, Thomas Björk-Eriksson, Eva Hammerlid
Objective: The purpose of this study was to prospectively and longitudinally compare the health-related quality of life (HRQOL) outcomes between head and neck (HN) cancer patients treated with parotid-sparing intensity modulated radiation therapy (IMRT) and patients treated with 3-dimensional conventional radiation therapy (3D-CRT). Methods and materials: Before and up to 12 months after treatment, HRQOL was recorded in patients with HN cancer who were referred to the Department of Oncology at Sahlgrenska University Hospital for curative IMRT...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29061656/synergistic-antiproliferative-activity-of-the-rad51-inhibitor-ibr2-with-inhibitors-of-receptor-tyrosine-kinases-and-microtubule-protein
#12
Peter J Ferguson, Mark D Vincent, James Koropatnick
Although cancer cell genetic instability contributes to characteristics that mediate tumorigenicity, it also contributes to the tumor-selective toxicity of some chemotherapy drugs. This synthetic lethality can be enhanced by inhibitors of DNA repair. To exploit this potential Achilles heel, we tested the ability of a RAD51 inhibitor to potentiate the cytotoxicity of chemotherapy drugs. 2-(Benzylsulfonyl)-1-(1H-indol-3-yl)-1,2-dihydroisoquinoline (IBR2) inhibits RAD51-mediated DNA double-strand break repair but also enhances cytotoxicity of the Bcr-Abl inhibitor imatinib...
January 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29033672/role-of-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-the-evaluation-of-head-and-neck-carcinoma
#13
REVIEW
Moheieldin M Abouzied, Ahmed Fathala, Abdulaziz Alsugair, Ahmad I Al Muhaideb, Mohammed H Al Qahtani
Fluorodeoxyglucose (FDG)-positron emission tomography-computed tomography (PET-CT) has been playing a pivotal role in tumor imaging for the past 20 years. Head and neck (HN) cancers are a good example that can illustrate such unique role of FDG imaging contributing to the patient's management. In this review article, we will describe the normal physiological distribution of FDG within HN structures focusing on its limitations and pitfalls. In addition, we will be also describing its role in the initial staging and restaging of the disease, particularly with regard to therapy response assessment...
October 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29029767/pet-ct-and-pet-mri-in-head-and-neck-malignancy
#14
REVIEW
T A Szyszko, G J R Cook
Combined 2-[ 18 F]-fluoro-2-deoxy-d-glucose (FDG) positron-emission tomography (PET)/computed tomography (CT) has an established role in the staging of difficult cases of head and neck (HN) squamous cell carcinoma (SCC), looking for an unknown primary, assessing response post-chemotherapy at 3-6 months, and differentiating relapse from treatment effects in patients suspected to have tumour recurrence. The PET NECK trial, comparing PET/CT surveillance versus neck dissection in advanced head and neck cancer showed survival was similar among patients who underwent PET/CT-guided surveillance and those who underwent planned neck dissection, but surveillance was more cost-effective...
January 2018: Clinical Radiology
https://www.readbyqxmd.com/read/28888224/long-term-patient-reported-outcomes-following-radiation-therapy-for-oropharyngeal-cancer-cross-sectional-assessment-of-a-prospective-symptom-survey-in-patients-%C3%A2-65%C3%A2-years-old
#15
Salman A Eraj, Mona K Jomaa, Crosby D Rock, Abdallah S R Mohamed, Blaine D Smith, Joshua B Smith, Theodora Browne, Luke C Cooksey, Bowman Williams, Brandi Temple, Kathryn E Preston, Jeremy M Aymard, Neil D Gross, Randal S Weber, Amy C Hessel, Renata Ferrarotto, Jack Phan, Erich M Sturgis, Ehab Y Hanna, Steven J Frank, William H Morrison, Ryan P Goepfert, Stephen Y Lai, David I Rosenthal, Tito R Mendoza, Charles S Cleeland, Kate A Hutcheson, Clifton D Fuller, Adam S Garden, G Brandon Gunn
BACKGROUND: Given the potential for older patients to experience exaggerated toxicity and symptoms, this study was performed to characterize patient reported outcomes in older patients following definitive radiation therapy (RT) for oropharyngeal cancer (OPC). METHODS: Cancer-free head and neck cancer survivors (>6 months since treatment completion) were eligible for participation in a questionnaire-based study. Participants completed the MD Anderson Symptom Inventory-Head and Neck module (MDASI-HN)...
September 9, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28865046/prospective-experience-of-percutaneous-endoscopic-gastrostomy-tubes-placed-by-otorhinolaryngologist-head-and-neck-surgeons-safe-and-efficacious
#16
Johanna Ruohoalho, Katri Aro, Antti A Mäkitie, Timo Atula, Aaro Haapaniemi, Harri Keski-Säntti, Leena Kylänpää, Annika Takala, Leif J Bäck
Percutaneous endoscopic gastrostomy (PEG) is often the treatment of choice in head and neck cancer (HNC) patients needing long-term nutritional support. Prospective studies on PEG tube placement in an otorhinolaryngologist service are lacking. At our hospital, otolaryngologist-head and neck (ORL-HN) surgeons-have performed PEG insertions for HNC patients since 2008. We prospectively analyzed 127 consecutive HNC patients who received their PEG tubes at the Department of Otorhinolaryngology-head and neck surgery, and evaluated the outcome of PEG tube insertions performed by ORL-HN surgeons...
November 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28841392/nutrition-care-in-patients-with-head-and-neck-or-esophageal-cancer-the-patient-perspective
#17
Cathy Alberda, Tatjana Alvadj-Korenic, Maria Mayan, Leah Gramlich
BACKGROUND: Patients with head/neck or esophageal (HNE) cancer are likely to develop malnutrition throughout the course of their disease and its treatment. Although nutrition care is considered a cornerstone of disease management, clinical practices to treat malnutrition vary. The objective of this qualitative study is to understand the patients' experiences with nutrition care in the context of their treatment and recovery. METHODS: A descriptive qualitative study design was used to explore patients' experiences...
October 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28816028/epidemiology-of-head-and-neck-cancer-in-thailand
#18
REVIEW
Napadon Tangjaturonrasme, Patravoot Vatanasapt, Andrey Bychkov
Cancer is the most common cause of death in Thailand, with the mortality almost doubled during 1998-2011 (from 48.4 to 95.2 per 100 000). The estimated number of new cancer cases in 2011 was 112 392. Our review provides baseline data on the current epidemiological situation with head and neck (HN) cancer in Thailand based on reports of the National Cancer Registry and findings from local and international publications. Collectively, HN cancer approaches age-standardized rate (ASR) incidence of 15.7 and 10...
August 16, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28803237/atf3-dependent-regulation-of-egr1-in-vitro-and-in-vivo
#19
Ilona Schoen, Sabine Koitzsch
BACKGROUND/AIMS: Activating transcription factor 3 (ATF3) and early growth response protein 1 (EGR1) are reported to interact, but their use as prognostic factors in cancer is discussed controversially. METHODS: We measured ATF3 and EGR1 gene expression changes in human mini-organ cultures (MOCs) of healthy nasal epithelia, UM-SCC-22B, and FADUDD cells after acid reflux exposure. Next, ATF3 and EGR1 gene expression was analysed in tumour tissues and related to the median expression of autologous reference tissue samples...
2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28775281/voxel-based-analysis-unveils-regional-dose-differences-associated-with-radiation-induced-morbidity-in-head-and-neck-cancer-patients
#20
Serena Monti, Giuseppe Palma, Vittoria D'Avino, Marianna Gerardi, Giulia Marvaso, Delia Ciardo, Roberto Pacelli, Barbara A Jereczek-Fossa, Daniela Alterio, Laura Cella
The risk of radiation-induced toxicity in patients treated for head and neck (HN) cancer with radiation therapy (RT) is traditionally estimated by condensing the 3D dose distribution into a monodimensional cumulative dose-volume histogram which disregards information on dose localization. We hypothesized that a voxel-based approach would identify correlations between radiation-induced morbidity and local dose release, thus providing a new insight into spatial signature of radiation sensitivity in composite regions like the HN district...
August 3, 2017: Scientific Reports
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