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idiopathic dilated cardiomyopathy

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https://www.readbyqxmd.com/read/28735322/viral-infection-of-the-heart-pathogenesis-and-diagnosis
#1
Mateusz Kuffner, Agnieszka Pawlak, Maciej Przybylski
Viral infections of the heart cause serious clinical problems, either as infectious myocarditis, which usually is a consequence of acute infection or as idiopathic dilated cardiomyopathy, resulting rather from a chronic infection. This minireview presents an up-to-date view on pathomechanisms of viral infection of the heart tissues, the role of immune system in controlling infectious process at its various stages and current possibilities of recognizing viral infection of the heart with use of both cardiological and virological methods...
January 2, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/28701682/prognostic-impact-of-segmental-wall-motion-abnormality-in-patients-with-idiopathic-dilated-cardiomyopathy
#2
Yuichiro Iida, Takayuki Inomata, Toyoji Kaida, Teppei Fujita, Yuki Ikeda, Takeru Nabeta, Shunsuke Ishii, Toshimi Koitabashi, Ichiro Takeuchi, Junya Ako
The clinical impact of left ventricular (LV) segmental wall motion abnormalities (SWMA) in patients with idiopathic dilated cardiomyopathy (IDCM) has not been well elucidated.Among 100 consecutive IDCM patients with follow-up visits, we enrolled 85 after excluding those with left bundle branch block and/or ventricular pacemaker implantation. LV wall motion was assessed using left ventriculography scored for 7 segments according to the American Heart Association classification as follows: 0, normokinesis; 1, hypokinesis; 2, akinesis; and 3, dyskinesis...
July 13, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28696268/personalizing-risk-stratification-for-sudden-death-in-dilated-cardiomyopathy-the-past-present-and-future
#3
REVIEW
Brian P Halliday, John G F Cleland, Jeffrey J Goldberger, Sanjay K Prasad
Results from the DANISH Study (Danish Study to Assess the Efficacy of ICDs in Patients With Non-Ischemic Systolic Heat Failure on Mortality) suggest that for many patients with dilated cardiomyopathy (DCM), implantable cardioverter-defibrillators do not increase longevity. Accurate identification of patients who are more likely to die of an arrhythmia and less likely to die of other causes is required to ensure improvement in outcomes and wise use of resources. Until now, left ventricular ejection fraction has been used as a key criterion for selecting patients with DCM for an implantable cardioverter-defibrillator for primary prevention purposes...
July 11, 2017: Circulation
https://www.readbyqxmd.com/read/28663761/clinical-outcome-of-cardiac-resynchronization-therapy-in-dilated-phase-hypertrophic-cardiomyopathy
#4
Min Gu, Han Jin, Wei Hua, Xiao-Han Fan, Hong-Xia Niu, Tao Tian, Li-Gang Ding, Jing Wang, Cong Xue, Shu Zhang
BACKGROUNDS: Clinical trials have demonstrated that cardiac resynchronization therapy (CRT) is effective in patients with "non-ischemic cardiomyopathy". However, patients with dilated-phase hypertrophic cardiomyopathy (DHCM) have been generally excluded from such trials. We aimed to compare the clinical outcome of CRT in patients with DHCM, idiopathic dilated cardiomyopathy (IDCM), or ischemic cardiomyopathy (ICM). METHODS: A total of 312 consecutive patients (DHCM: n = 16; IDCM: n = 231; ICM: n = 65) undergoing CRT in Fuwai hospital were studied respectively...
April 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/28614834/left-ventricular-mechanical-reverse-remodelling-not-followed-by-electrical-reverse-remodelling-a-case-report
#5
Sandra Amorim, Raquel Garcia, Teresa Pinho, João Rodrigues, Filipe Macedo, José Silva-Cardoso, M Júlia Maciel
Patients with severely depressed left ventricular ejection fractions (LVEFs) receive implantable cardioverter-defibrillators (ICDs) for the primary prevention of sudden death. However, in some patients, LVEFs may improve or even normalize over time, and these patients would no longer be qualified for ICD implantation based on the original criteria for which they have initially received an ICD. We report a patient with idiopathic dilated cardiomyopathy whose LVEF recovered to normal values after pharmacological therapy...
June 15, 2017: Cardiology
https://www.readbyqxmd.com/read/28603826/differences-between-idiopathic-and-ischemic-dilated-cardiomyopathy
#6
Sana Fennira, Ihsen Zairi, Zouhaier Jnifene, Mariem Lakhal, Sofiene Kammoun, Sondos Kraiem
BACKGROUND: Ischemic cardiomyopathy can be reversible after revascularization hence the interest of making systematic coronary angiography that remain an invasive procedure. AIM: To detect epidemiological, clinical and paraclinical differences between idiopathic and ischemic dilated cardiomyopathy to identify predictors of coronary artery disease and to evaluate the interest of making systematic coronary angiography within the etiological check-up of dilated cardiomyopathy...
August 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28603002/association-of-preprocedural-cardiac-magnetic-resonance-imaging-with-outcomes-of-ventricular-tachycardia-ablation-in-patients-with-idiopathic-dilated-cardiomyopathy
#7
Konstantinos C Siontis, Hyungjin Myra Kim, Ghaith Sharaf Dabbagh, Rakesh Latchamsetty, Jadranka Stojanovska, Krit Jongnarangsin, Fred Morady, Frank M Bogun
BACKGROUND: Knowledge of complex arrhythmogenic substrates can help plan ventricular tachycardia (VT) ablation in patients with idiopathic dilated cardiomyopathy (DCM). OBJECTIVE: The purpose of this study was to assess whether preprocedural late gadolinium enhancement magnetic resonance imaging (LGE-MRI) can improve ablation outcomes in DCM. METHODS: Consecutive patients (N = 96) with idiopathic DCM underwent VT ablation with open-irrigated catheters (2006-2016)...
June 9, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28591770/inferolateral-early-repolarization-among-non-ischaemic-sudden-cardiac-death-victims
#8
Lauri T A Holmström, Mira A Haukilahti, Jani T Tikkanen, Aapo L Aro, Tuomas V Kenttä, Marja-Leena Kortelainen, Heikki V Huikuri, Matti J Junttila
Aim: Inferolateral early repolarization (ER) has been associated with an increased risk of sudden cardiac death (SCD). However, this association is thought to be mainly due to ischaemic SCD. The association of ER and non-ischaemic SCD has not been studied. The aim was to evaluate whether inferolateral ER is associated with non-ischaemic SCD. Methods and results: Study population consists of 275 consecutive victims of non-ischaemic SCD with 12-lead ECG and control group of general population cohort with 10 864 subjects...
June 7, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28567076/hereditary-dilated-cardiomyopathy-recent-advances-in-genetic-diagnostics
#9
REVIEW
Hyun-Young Park
Dilated cardiomyopathy (DCM) is the most common cause of heart failure in young adults and up to 50% of idiopathic DCM is thought to be caused by genetic mutations in candidate genes. Although a genetic diagnosis can confirm a clinical diagnosis of hereditary DCM, genetic testing has not been easily accessible due to genetic heterogeneity and complexity. Next-generation sequencing (NGS) technologies have recently been introduced, and genetic testing for multiple genes is currently available and more than 40 different genes have been associated with DCM...
May 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28557183/extracellular-vesicles-do-not-contribute-to-higher-circulating-levels-of-soluble-lrp1-in-idiopathic-dilated-cardiomyopathy
#10
Santiago Roura, Carolina Gálvez-Montón, David de Gonzalo-Calvo, Ana Gámez Valero, Paloma Gastelurrutia, Elena Revuelta-López, Cristina Prat-Vidal, Carolina Soler-Botija, Aida Llucià-Valldeperas, Isaac Perea-Gil, Oriol Iborra-Egea, Francesc E Borràs, Josep Lupón, Vicenta Llorente-Cortés, Antoni Bayes-Genis
Idiopathic dilated cardiomyopathy (IDCM) is a frequent cause of heart transplantation. Potentially valuable blood markers are being sought, and low-density lipoprotein receptor-related protein 1 (LRP1) has been linked to the underlying molecular basis of the disease. This study compared circulating levels of soluble LRP1 (sLRP1) in IDCM patients and healthy controls and elucidated whether sLRP1 is exported out of the myocardium through extracellular vesicles (EVs) to gain a better understanding of the pathogenesis of the disease...
May 29, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28539455/functional-consequences-of-rna-5-terminal-deletions-on-coxsackievirus-b3-rna-replication-and-ribonucleoprotein-complex-formation
#11
Nicolas Lévêque, Magali Garcia, Alexis Bouin, Joseph H C Nguyen, Genevieve P Tran, Laurent Andreoletti, Bert L Semler
Group B coxsackieviruses are responsible for chronic cardiac infections. However, the molecular mechanisms by which the virus can persist in the human heart long after the signs of acute myocarditis have abated are still not completely understood. Recently, coxsackievirus B3 strains with 5' terminal deletions in genomic RNAs were isolated from a patient suffering from idiopathic dilated cardiomyopathy, suggesting that such mutant viruses may be the forms responsible for persistent infection. These deletions lacked portions of 5' stem-loop I, which is an RNA secondary structure required for viral RNA replication...
May 24, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28497865/predictors-and-implications-of-early-left-ventricular-ejection-fraction-improvement-in-new-onset-idiopathic-nonischemic-cardiomyopathy-with-narrow-qrs-complex-a-neolith-substudy
#12
Norman C Wang, Evan C Adelstein, Sandeep K Jain, Stuart G Mendenhall, Alaa A Shalaby, Andrew H Voigt, Samir Saba
BACKGROUND: Predictors and implications of early left ventricular ejection fraction (LVEF) improvement with guideline-directed medical therapy (GDMT) in new-onset idiopathic nonischemic cardiomyopathy (NICM) with narrow QRS complex are not well described. The objectives were to describe predictors of LVEF improvement after 3 months on GDMT and adverse cardiac events based on post-GDMT LVEF status (≤35% vs. >35%). METHODS: A retrospective cohort study was performed in subjects with new-onset NICM, LVEF ≤35%, and narrow QRS complex...
May 12, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28472305/recessive-taf1a-mutations-reveal-ribosomopathy-in-siblings-with-end-stage-pediatric-dilated-cardiomyopathy
#13
Pamela A Long, Jeanne L Theis, Yu-Huan Shih, Joseph J Maleszewski, Patrice C Abell Aleff, Jared M Evans, Xiaolei Xu, Timothy M Olson
Non-ischemic dilated cardiomyopathy (DCM) has been recognized as a heritable disorder for over 25 years, yet clinical genetic testing is non-diagnostic in > 50% of patients, underscoring the ongoing need for DCM gene discovery. Here, whole exome sequencing uncovered a novel molecular basis for idiopathic end-stage heart failure in two sisters who underwent cardiac transplantation at three years of age. Compound heterozygous recessive mutations in TAF1A, encoding an RNA polymerase I complex protein, were associated with marked fibrosis of explanted hearts and gene-specific nucleolar segregation defects in cardiomyocytes, indicative of impaired ribosomal RNA synthesis...
May 2, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28471539/sokolow-lyon-voltage-is-suitable-for-monitoring-improvement-in-cardiac-function-and-prognosis-of-patients-with-idiopathic-dilated-cardiomyopathy
#14
Kenji Fukaya, Kyosuke Takeshita, Takahiro Okumura, Hiroaki Hiraiwa, Soichiro Aoki, Takeo Ichii, Yuki Sugiura, Katsuhide Kitagawa, Toru Kondo, Naoki Watanabe, Naoaki Kano, Kenji Furusawa, Akinori Sawamura, Ryota Morimoto, Yasuko Bando, Toyoaki Murohara
BACKGROUND: The clinical significance of electrocardiogram in the assessment of patients with idiopathic dilated cardiomyopathy (IDCM) is currently unknown. The aim of this study was to determine the feasibility of recording serial changes in Sokolow-Lyon voltage (∆%QRS-voltage) in one year to estimate left ventricular reverse remodeling (LVRR) and predict a prognosis of IDCM patients under tailored medical therapy. METHODS: Sixty-eight consecutive patients with mild symptoms (52...
February 3, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28449952/heart-transplantation-in-giant-cell-myocarditis-analysis-of-the-united-network-for-organ-sharing-registry
#15
Chantal A Elamm, Sadeer G Al-Kindi, Christopher M Bianco, Bishnu P Dhakal, Guilherme H Oliveira
BACKGROUND: Giant cell myocarditis (GCM) is a lethal, rapidly progressive disease, for which heart transplantation is the treatment of choice. We sought to describe the characteristics and outcomes of patients with GCM who undergo heart transplantation. METHODS AND RESULTS: We used the United Network for Organ Sharing thoracic organ transplantation registry to identify adults with GCM as the primary diagnosis and compared their characteristics and outcomes with patients who underwent transplantation for other types of myocarditis and for idiopathic dilated cardiomyopathy (IDCMP)...
April 24, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28444133/increased-collagen-within-the-transverse-tubules-in-human-heart-failure
#16
David J Crossman, Xin Shen, Mia Jüllig, Michelle Munro, Yufeng Hou, Martin Middleditch, Darshan Shrestha, Amy Li, Sean Lal, Cristobal G Dos Remedios, David Baddeley, Peter N Ruygrok, Christian Soeller
Aims: In heart failure transverse-tubule (t-tubule) remodelling disrupts calcium release, and contraction. T-tubules in human failing hearts exhibit increased labelling by wheat germ agglutinin (WGA), a lectin that binds to the dystrophin-associated glycoprotein complex. We hypothesized changes in this complex may explain the increased WGA labelling and contribute to t-tubule remodelling in the failing human heart. In this study we sought to identify the molecules responsible for this increased WGA labelling...
April 20, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28438355/early-and-frequent-defibrillator-discharge-in-patients-with-cardiac-sarcoidosis-compared-with-patients-with-idiopathic-dilated-cardiomyopathy
#17
Yoichi Takaya, Kengo Kusano, Nobuhiro Nishii, Kazufumi Nakamura, Hiroshi Ito
BACKGROUND: Little is known about the suitability of implantable cardioverter defibrillator (ICD) implantation in patients with cardiac sarcoidosis (CS). We evaluated the efficacy of ICD implantation in patients with CS, including suspected CS, compared with those with idiopathic dilated cardiomyopathy (DCM). METHODS: A total of 102 consecutive patients with definite CS, suspected CS, or DCM who underwent ICD implantation were enrolled. The endpoint was the first documentation of appropriate ICD therapy for ventricular tachyarrhythmias...
April 19, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28290821/-detection-of-autoantibodies-against-the-1-adrenergic-receptor-in-the-sera-of-patients-via-the-competitive-cell-based-enzyme-linked-immunosorbent-assay
#18
A Y Shevelev, M V Kostiukevich, E E Efremov, T N Vlasik, N A Mironova, K A Zykov, N M Kashirina, I B Kuznetsova, T V Sharf, E N Mamochkina, L N Lipatova, M M Peklo, P N Rutkevich, E V Yanushevskaya, I N Rybalkin, O V Stukalova, T A Malkina, M M Belyaeva, T V Kuznetsova, G A Tkachev, L V Zinchenko, E M Gupalo, O Y Agapova, T V Yureneva-Tkhorzhevskaya, A V Rvacheva, M V Sidorova, A S Sadgyan, S N Tereshchenko, S P Golitsyn
OBJECTIVE: This study aimed to assess the level of anti-1-adrenergic receptor autoantibodies in patients with ventricular arrhythmias with no signs of organic heart disease and with presence of cardiovascular pathology in comparison with a group of healthy volunteers. MATERIAL AND METHODS: The study included 44 patients with ventricular arrhythmias with no signs of organic heart disease ("idiopathic"), 34 patients with diagnosed dilated cardiomyopathy (DCM) of inflammatory origin, 35 patients with coronary heart disease and ventricular arrhythmias, 12patients with coronary heart disease with no ventricular arrhythmias, and 19 healthy volunteers (control group)...
December 2016: Kardiologiia
https://www.readbyqxmd.com/read/28289528/clinical-cardiac-regenerative-studies-in-children
#19
REVIEW
Imre J Pavo, Ina Michel-Behnke
Although the incidence of pediatric heart failure is low, the mortality is relatively high, with severe clinical symptoms requiring repeated hospitalization or intensive care treatment in the surviving patients. Cardiac biopsy specimens have revealed a higher number of resident human cardiac progenitor cells, with greater proliferation and differentiation capacity, in the neonatal period as compared with adults, demonstrating the regeneration potential of the young heart, with rising interest in cardiac regeneration therapy in critically ill pediatric patients...
February 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28288703/erratum-to-prevalence-predictors-and-prognosis-of-ventricular-reverse-remodeling-in-idiopathic-dilated-cardiomyopathy-rev-port-cardiol-2016-35-5-253-260
#20
Sandra Amorim, Manuel Campelo, Elisabete Martins, Brenda Moura, Alexandra Sousa, Teresa Pinho, José Silva-Cardoso, Maria Júlia Maciel
No abstract text is available yet for this article.
March 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
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