keyword
https://read.qxmd.com/read/38522306/interstitial-ectopic-pregnancy-a-rare-case-report
#21
Majd Sabbagh, Nehad Othman, Salah Chaikha, Rehab Sukkar, Amal alToto, Lina alQudsi
INTRODUCTION: Interstitial pregnancies are a rare form of ectopic pregnancy with life threatening consequences. Thus, the aim of this report is to shed light on the importance of early diagnosis for optimal outcomes. CASE PRESENTATION: Herein, we present a case of an interstitial ectopic pregnancy in a 31-year-old Syrian female who presented only with mild non-specific abdominal pain. The ultrasound showed a gestational sac in the right horn of the uterus non-communicating with the endometrial cavity suggesting an interstitial ectopic pregnancy...
March 18, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38521925/development-validation-and-reliability-of-the-chrononutrition-profile-questionnaire-pregnancy-cpq-p
#22
JOURNAL ARTICLE
Ee Yin Kok, Satvinder Kaur, Nurul Husna Mohd Shukri, Nurliyana Abdul Razak, Masaki Takahashi
BACKGROUND: During pregnancy, physiological changes can affect eating and sleeping habits, which may eventually have negative consequences for maternal and foetal health. To better understand these changes, it is essential to develop a reliable questionnaire that addresses lifestyle habits such as snacking and daytime napping. This study aimed to determine the validity and reliability of the Chrononutrition Profile Questionnaire-Pregnancy (CPQ-P). METHODS: A total of 399 women in their second and third trimester of pregnancy were recruited from government maternal and child health clinics in Kuala Lumpur and Putrajaya and completed a self-administered online questionnaire...
March 23, 2024: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/38521816/developmental-expression-of-catecholamine-system-in-the-human-placenta-and-rat-fetoplacental-unit
#23
JOURNAL ARTICLE
Rona Karahoda, Veronika Vachalova, Ramon Portillo, Filip Mahrla, Mireia Viñas-Noguera, Cilia Abad, Frantisek Staud
Catecholamines norepinephrine and dopamine have been implicated in numerous physiological processes within the central nervous system. Emerging evidence has highlighted the importance of tightly regulated monoamine levels for placental functions and fetal development. However, the complexities of synthesis, release, and regulation of catecholamines in the fetoplacental unit have not been fully unraveled. In this study, we investigated the expression of enzymes and transporters involved in synthesis, degradation, and transport of norepinephrine and dopamine in the human placenta and rat fetoplacental unit...
March 23, 2024: Scientific Reports
https://read.qxmd.com/read/38521046/pregnancy-exposure-to-pm-2-5-from-wildland-fire-smoke-and-preterm-birth-in-california
#24
JOURNAL ARTICLE
Sally Picciotto, ShihMing Huang, Frederick Lurmann, Nathan Pavlovic, Shih Ying Chang, Anondo Mukherjee, Dana E Goin, Rachel Sklar, Elizabeth Noth, Rachel Morello-Frosch, Amy M Padula
BACKGROUND: Wildfires in the Western United States are a growing and significant source of air pollution that is eroding decades of progress in air pollution reduction. The effects on preterm birth during critical periods of pregnancy are unknown. METHODS: We assessed associations between prenatal exposure to wildland fire smoke and risk of preterm birth (gestational age < 37 weeks). We assigned smoke exposure to geocoded residence at birth for all live singleton births in California conceived 2007-2018, using weekly average concentrations of particulate matter ≤ 2...
March 16, 2024: Environment International
https://read.qxmd.com/read/38520846/worse-histopathology-and-prognosis-in-women-with-breast-cancer-diagnosed-during-the-second-trimester-of-pregnancy
#25
JOURNAL ARTICLE
L Gkekos, F E Lundberg, K Humphreys, I Fredriksson, A L V Johansson
BACKGROUND: Evidence suggests that women with breast cancer diagnosed during pregnancy (PrBC) and within 2 years of delivery (PPBC) have similar survival compared to women diagnosed not near pregnancy if adjusted for stage and subtype. To investigate whether this is true for all subtypes and for both pregnancy and post-delivery periods, we examined clinicopathologic features and survival in women with breast cancer by trimesters and 6-month post-delivery intervals. MATERIALS AND METHODS: Women diagnosed with invasive breast cancer during 1992-2018 at ages 18-44 years were identified in the Swedish Cancer Register, with information on childbirths from the Swedish Multi-Generation Register and clinical data from Breast Cancer Quality Registers...
March 22, 2024: ESMO Open
https://read.qxmd.com/read/38520674/lethal-multiple-pterygium-syndrome-large-cystic-hygroma-and-cleft-palate-rare-and-severe-fetal-presentations-of-ryr1-%C3%A2-and-neb-related-congenital-myopathies
#26
Molly Jackson, Mary Ann Thomas, Ian Suchet, Houman Mahallati, Verena Kuret, Julie Lauzon
Congenital myopathies are a genetically heterogeneous group of neuromuscular disorders that commonly present with congenital hypotonia and weakness but can also present broadly. The most severe presentation is neonatal with arthrogryposis and, rarely, fetal akinesia and pterygia, features also seen in lethal multiple pterygium syndrome (LMPS). We describe two fetuses with similar phenotype, including hydrops fetalis, large cystic hygromas, bilateral talipes, and fetal akinesia in the second trimester. Genetic diagnoses were made using exome sequencing...
March 23, 2024: Prenatal Diagnosis
https://read.qxmd.com/read/38520563/evaluation-of-changes-in-exhausted-t-lymphocytes-and-mirnas-expression-in-the-different-trimesters-of-pregnancy-in-pregnant-women
#27
JOURNAL ARTICLE
Ali Akbar Shekarchi, Leila Hosseini, Amin Kamrani, Iraj Alipourfard, Mohammad Sadegh Soltani-Zangbar, Morteza Akbari, Leila Roshangar, Leili Aghebati-Maleki, Forough Chakari-Khiavi, Aref Chakari-Khiavi, Kimia Motlagh Asghari, Shahla Danaii, Tannaz Pourlak, Javad Ahmadian Heris, Mehdi Yousefi
BACKGROUND: Throughout the three trimesters of a typical pregnancy, we looked at changes in the expression of miRNAs and exhausted T lymphocytes for this study. METHODS AND RESULTS: Fifty healthy subjects were included in this study. The frequency of exhausted T lymphocytes was measured in isolated PBMCs using flow cytometry. PD-1, TIM-3, and related miRNAs gene expression were assessed using qRT-PCR. The analyses revealed a significant decline in PD-1 and Tim-3 expression in PBMCs from RPL women (p = 0...
March 23, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38519904/association-of-maternal-nutritional-status-and-small-for-gestational-age-neonates-in-peri-urban-communities-of-karachi-pakistan-findings-from-the-prisma-study
#28
JOURNAL ARTICLE
Sobia Ambreen, Nida Yazdani, Abdul Salam Alvi, Muhammad Farrukh Qazi, Zahra Hoodbhoy
BACKGROUND: Early pregnancy nutritional status can be associated with adverse birth outcomes such as small-for-gestational age (SGA) and low birth weight (LBW). BMI (Body Mass Index) and MUAC (Mid-upper arm circumference) are easy to use assessments and are indicative of the pre-pregnancy nutritional status if obtained in the first trimester. This study primarily assesses the association of maternal nutritional status using BMI and MUAC with SGA in a community-based cohort of Pakistani women...
March 22, 2024: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/38519895/pregnancy-health-in-a-multi-state-u-s-population-of-systemically-underserved-patients-and-their-children-promise-cohort-design-and-baseline-characteristics
#29
JOURNAL ARTICLE
Janne Boone-Heinonen, Kristin Lyon-Scott, Rachel Springer, Teresa Schmidt, Kimberly K Vesco, Anna Booman, Dang Dinh, Stephen P Fortmann, Byron A Foster, Jenny Hauschildt, Shuling Liu, Jean O'Malley, Amy Palma, Jonathan M Snowden, Kalera Stratton, Sarah Tran
BACKGROUND: Gestational weight gain (GWG) is a routinely monitored aspect of pregnancy health, yet critical gaps remain about optimal GWG in pregnant people from socially marginalized groups, or with pre-pregnancy body mass index (BMI) in the lower or upper extremes. The PROMISE study aims to determine overall and trimester-specific GWG associated with the lowest risk of adverse birth outcomes and detrimental infant and child growth in these underrepresented subgroups. This paper presents methods used to construct the PROMISE cohort using electronic health record data from a network of community-based healthcare organizations and characterize the cohort with respect to baseline characteristics, longitudinal data availability, and GWG...
March 23, 2024: BMC Public Health
https://read.qxmd.com/read/38519794/perinatal-compromise-affects-development-form-and-function-of-the-hippocampus-part-one-clinical-studies
#30
REVIEW
Tegan A White, Suzanne L Miller, Amy E Sutherland, Beth J Allison, Emily J Camm
The hippocampus is a neuron-rich specialised brain structure that plays a central role in the regulation of emotions, learning and memory, cognition, spatial navigation, and motivational processes. In human fetal development, hippocampal neurogenesis is principally complete by mid-gestation, with subsequent maturation comprising dendritogenesis and synaptogenesis in the third trimester of pregnancy and infancy. Dendritogenesis and synaptogenesis underpin connectivity. Hippocampal development is exquisitely sensitive to perturbations during pregnancy and at birth...
March 22, 2024: Pediatric Research
https://read.qxmd.com/read/38519592/diet-lifestyle-and-gut-microbiota-composition-among-malaysian-women-with-gestational-diabetes-mellitus-a-prospective-cohort-study
#31
JOURNAL ARTICLE
Thubasni Kunasegaran, Vinod R M T Balasubramaniam, Valliammai Jayanthi Thirunavuk Arasoo, Uma Devi Palanisamy, Yen Ker Tan, Amutha Ramadas
The study addressed a significant gap in the profiling and understanding of the gut microbiota's influence on Malaysian Malay women with gestational diabetes mellitus (GDM). This prospective cohort study aimed to explore the intricate relationship between gut microbiota, dietary choices, and lifestyle factors among Malay women, both with and without GDM. The research specifically focused on participants during the second (T0) and third (T1) trimesters of pregnancy in Johor Bahru, Malaysia. In Part 1 of the study, a diverse pool of pregnant women at T0 was categorized into two groups: those diagnosed with GDM and those without GDM, with a total sample size of 105 individuals...
March 22, 2024: Scientific Reports
https://read.qxmd.com/read/38519450/tgf%C3%AE-signalling-a-nexus-between-inflammation-placental-health-and-preeclampsia-throughout-pregnancy
#32
JOURNAL ARTICLE
Monika Horvat Mercnik, Carolin Schliefsteiner, Gonzalo Sanchez-Duffhues, Christian Wadsack
BACKGROUND: The placenta is a unique and pivotal organ in reproduction, controlling crucial growth and cell differentiation processes that ensure a successful pregnancy. Placental development is a tightly regulated and dynamic process, in which the transforming growth factor beta (TGFβ) superfamily plays a central role. This family of pleiotropic growth factors is heavily involved in regulating various aspects of reproductive biology, particularly in trophoblast differentiation during the first trimester of pregnancy...
March 22, 2024: Human Reproduction Update
https://read.qxmd.com/read/38519042/evaluation-of-fetal-breathing-related-nasal-fluid-flow-doppler-in-the-third-trimester-in-pregnant-women-with-fetal-growth-restriction-preliminary-observations
#33
JOURNAL ARTICLE
Gunay Rzayeva, İbrahim Kale, Resul Arısoy, Murat Muhcu
OBJECTIVE: To investigate the fetal breathing-related nasal fluid flow Doppler waveforms as an indicator of fetal respiratory function in fetuses diagnosed with fetal growth restriction (FGR) in the third trimester. MATERIALS AND METHODS: This prospective, non-interventional case-control study was conducted on 96 pregnant women, including 23 pregnant women diagnosed with FGR in the third trimester as the FGR group and 73 healthy pregnant women with fetuses appropriate for gestational age (AGA) as the control group...
March 22, 2024: Zeitschrift Für Geburtshilfe und Neonatologie
https://read.qxmd.com/read/38518486/evaluation-of-the-thyroid-gland-vascularity-during-pregnancy-using-2-dimensional-color-superb-microvascular-%C3%A4-maging-vascularization-index-technique
#34
JOURNAL ARTICLE
Fatih Ates, Ömer Faruk Topaloglu, Ozlem Secilmis, Görkem Aktas, Sibel Ozler, Mehmet Sedat Durmaz, Mustafa Koplay
PURPOSE: We aimed to investigate maternal thyroid parenchymal vascularity with 2-dimensional color superb microvascular imaging vascularization index (2D-cSMIVI) levels and thyroid gland volume in the first, second and third trimesters. METHODS: This longitudinal prospective study was carried out with participants selected from 30 healthy asymptomatic pregnant women. Ultrasonography (US) for the thyroid gland was performed in each trimester. The vascularization index (VI) values obtained by manually drawing the contours of the thyroid parenchyma in the longutidinal plane, using the free region of interest (ROI) with 2DcSMIVI mode...
March 20, 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/38518428/wildfire-particulate-exposure-and-risks-of-preterm-birth-and-low-birth-weight-in-the-southwestern-united-states
#35
JOURNAL ARTICLE
P Jiang, Y Li, M K Tong, S Ha, E Gaw, J Nie, P Mendola, M Wang
OBJECTIVES: Wildfire air pollution is a growing concern on human health. The study aims to assess the associations between wildfire air pollution and pregnancy outcomes in the Southwestern United States. STUDY DESIGN: This was a retrospective cohort study. METHODS: Birth records of 627,404 singleton deliveries in 2018 were obtained in eight states of the Southwestern United States and were linked to wildfire-sourced fine particulate matter (PM2...
March 21, 2024: Public Health
https://read.qxmd.com/read/38518425/association-of-maternal-obesity-with-growth-of-fetal-fractional-limb-volume
#36
JOURNAL ARTICLE
Satoru Ikenoue, Yohei Akiba, Ryota Ishii, Toshimitsu Otani, Yoshifumi Kasuga, Mamoru Tanaka
BACKGROUND: Maternal obesity influences birth weight and newborn adiposity. Fetal fractional limb volume has recently been introduced as a useful parameter for the proxy of fetal adiposity. However, the association between maternal adiposity and the growth of fetal fractional limb volume has not been examined. AIMS: To investigate the association of maternal pre-pregnancy BMI with the growth of fetal fractional limb volume. STUDY DESIGN: Prospective cohort study...
March 19, 2024: Early Human Development
https://read.qxmd.com/read/38518389/pfas-alters-placental-arterial-vasculature-in-term-human-placentae-a-prospective-pregnancy-cohort-study
#37
JOURNAL ARTICLE
Sadia Firoza Chowdhury, Nashae Prout, Zorimar Rivera-Núñez, Emily Barrett, Jessica Brunner, Zoe Duberstein, Kurunthachalam Kannan, Carolyn M Salafia, Ruchit Shah, Richard K Miller, Thomas G O'Connor
INTRODUCTION: Perfluoroalkyl substances (PFAS) are synthetic chemicals used in industrial and consumer goods that are widely detected in human populations and are associated with adverse health outcomes, including perinatal health risks and child health. One mechanism of influence may be the impact of PFAS exposure on placental structure and function. OBJECTIVES: The objective of this study is to investigate the relationship between maternal prenatal exposure to PFAS and measures of placental vascularization, and to assess whether changes in vascularization play a role in mediating the impact of PFAS on birth outcomes...
March 9, 2024: Placenta
https://read.qxmd.com/read/38518248/human-cerebellum-gangliosides-a-comprehensive-analysis-by-ion-mobility-tandem-mass-spectrometry
#38
JOURNAL ARTICLE
Maria Roxana Biricioiu, Mirela Sarbu, Raluca Ica, Željka Vukelić, David E Clemmer, Alina D Zamfir
The human cerebellum is an ultraspecialized region of the brain responsible for cognitive functions and movement coordination. The fine mechanisms through which the process of aging impacts such functions are not well understood; therefore, a rigorous exploration of this brain region at the molecular level is deemed necessary. Gangliosides, sialylated glycosphingolipids, highly and specifically expressed in the human central nervous system, represent possible molecular markers of cerebellum development and aging...
March 22, 2024: Journal of the American Society for Mass Spectrometry
https://read.qxmd.com/read/38517730/interaction-effects-of-mthfr-c677t-and-a1298c-polymorphisms-with-maternal-glycated-haemoglobin-levels-on-adverse-birth-outcomes
#39
JOURNAL ARTICLE
Weixiang Wu, Dan Luo, Cunwei Ji, Fuqiang Diao, Lihong Wu, Xiaolin Ruan, Chunming Gu, Mingyong Luo
AIMS: The role of maternal genetic factors in the association between high glycated haemoglobin (HbA1c) levels and adverse birth outcomes remains unclear. MATERIALS AND METHODS: In this study, the maternal HbA1c levels of 5108 normoglycemic pregnant women in China were measured, and A1298C and C677T polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene were genotyped. RESULTS: Elevated HbA1c levels during the second trimester were associated with increased risks of macrosomia, large-for-gestational age (LGA), preterm birth (PTB), and reduced gestational age (p < 0...
March 2024: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/38517534/sex-specific-association-between-maternal-mild-anemia-and-children-s-behavioral-development-a-birth-cohort-study
#40
JOURNAL ARTICLE
Xuemei Hao, Yufan Guo, Jingru Lu, Linlin Zhu, Shuangqin Yan, Fangbiao Tao, Kun Huang
There has been limited research on maternal anemia affecting children's behavioral development, with a lack of studies focusing on sex differences in this association. Based on the Ma'anshan Birth Cohort, 2132 mother-child pairs were included. Maternal anemia was evaluated based on the hemoglobin concentration and children's behavioral development was assessed by Achenbach Child Behavior Checklist 1.5-5. Binary logistic regression models indicated that compared with children born of mothers without anemia throughout pregnancy, maternal mild anemia during pregnancy or only anemia in the 3rd trimester was associated with increased risks of aggressive behaviors in boys...
March 22, 2024: European Child & Adolescent Psychiatry
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