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https://www.readbyqxmd.com/read/29141330/-prenatal-supplementations-of-iron-iron-containing-multimicronutrients-and-antianemic-chinese-patent-medicines-in-women-in-shaanxi-province-2010-2013
#1
D M Liu, J M Li, P F Qu, S N Dang, X Y Wu, R Zhang, H Yan, H Yan
Objective: To understand the prevalence of prenatal supplementations of iron, iron-containing multi-micronutrients (IMMN) and antianemic Chinese patent medicines (ACPM) and associated factors in women in Shaanxi province. Methods: A sample of 28 367 childbearing-age women who gave birth during 2010-2013 and had specific information of the prenatal nutrients supplementation were recruited using stratified multistage cluster random sampling in Shaanxi province. The information about their basic characteristics and prenatal supplementation of nutrients were collected by a questionnaire survey...
November 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29141178/peri-conception-and-first-trimester-diet-modifies-reproductive-development-in-bulls
#2
K J Copping, M D Ruiz-Diaz, C S Rutland, N P Mongan, M J Callaghan, I C McMillen, R J Rodgers, V E A Perry
Nutritional perturbation during gestation alters male reproductive development in rodents and sheep. In cattle both the developmental trajectory of the feto-placental unit and its response to dietary perturbations is dissimilar to that of these species. This study examined the effects of dietary protein perturbation during the peri-conception and first trimester periods upon reproductive development in bulls. Nulliparous heifers (n=360) were individually fed a high- or low-protein diet (HPeri and LPeri) from 60 days before conception...
November 16, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29139276/preventing-stroke-and-assessing-risk-in-women
#3
Tracey Keteepe-Arachi, Sanjay Sharma
Ischaemic stroke is rare in premenopausal women but risk increases with advancing age and doubles in the ten years following the menopause. Up to the age of 75 years men have a 25% higher risk of suffering a stroke compared with women. However, the increased life expectancy of women ultimately results in a higher overall incidence. Twice as many women die from stroke compare with breast cancer. Women with cerebrovascular disease are more likely to present with atypical symptoms than men. Altered mental status (including unresponsiveness, confusion and behavioural change) is the most common nonconventional symptom, and is reported by 23% of women compared with 15% of men...
March 2017: Practitioner
https://www.readbyqxmd.com/read/29136193/early-first-trimester-uteroplacental-flow-and-the-progressive-disintegration-of-spiral-artery-plugs-new-insights-from-contrast-enhanced-ultrasound-and-tissue-histopathology
#4
V H J Roberts, T K Morgan, P Bednarek, M Morita, G J Burton, J O Lo, A E Frias
STUDY QUESTION: Does the use of a vascular contrast agent facilitate earlier detection of maternal flow to the placental intervillous space (IVS) in the first trimester of pregnancy? SUMMARY ANSWER: Microvascular filling of the IVS was demonstrated by contrast-enhanced ultrasound from 6 weeks of gestation onwards, earlier than previously believed. WHAT IS KNOWN ALREADY: During placental establishment and remodeling of maternal spiral arteries, endovascular trophoblast cells invade and accumulate in the lumen of these vessels to form 'trophoblast plugs'...
November 10, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29136159/associations-between-maternal-lifestyle-factors-and-neonatal-body-composition-in-the-screening-for-pregnancy-endpoints-cork-cohort-study
#5
Darren L Dahly, Xia Li, Hazel A Smith, Ali S Khashan, Deirdre M Murray, Mairead E Kiely, Jonathan O'B Hourihane, Fergus P McCarthy, Louise C Kenny, Patricia M Kearney
Background: Neonatal body composition likely mediates fetal influences on life long chronic disease risk. A better understanding of how maternal lifestyle is related to newborn body composition could thus inform intervention efforts. Methods: Using Cork participant data (n = 1754) from the Screening for Pregnancy Endpoints (SCOPE) cohort study [ECM5(10)05/02/08], we estimated how pre-pregnancy body size, gestational weight gain, exercise, alcohol, smoking and diet were related to neonatal fat and fat-free mass, as well as length and gestational age at birth, using quantile regression...
November 10, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29136018/adverse-obstetric-outcomes-in-pregnant-women-with-uterine-fibroids-in-china-a-multicenter-survey-involving-112-403-deliveries
#6
Rong Zhao, Xin Wang, Liying Zou, Guanghui Li, Yi Chen, Changdong Li, Weiyuan Zhang
OBJECTIVE: To estimate the association between uterine fibroids and adverse obstetric outcomes. METHODS: This was a retrospective cross-sectional study of 112,403 deliveries from 14 provinces and 39 different hospitals in 2011 in mainland China. We compared pregnancy outcomes in women with and without uterine fibroids who underwent detailed second trimester obstetric ultrasonography during 18 to 22 weeks. Obstetric outcomes include cesarean delivery, breech presentation, preterm delivery, placenta previa, placental abruption, premature rupture of membranes and neonatal birthweight...
2017: PloS One
https://www.readbyqxmd.com/read/29135438/exposure-to-perfluoroalkyl-substances-and-metabolic-outcomes-in-pregnant-women-evidence-from-the-spanish-inma-birth-cohorts
#7
Nuria Matilla-Santander, Damaskini Valvi, Maria-Jose Lopez-Espinosa, Cyntia B Manzano-Salgado, Ferran Ballester, Jesús Ibarluzea, Loreto Santa-Marina, Thomas Schettgen, Mònica Guxens, Jordi Sunyer, Martine Vrijheid
BACKGROUND: Exposure to perfluoroalkyl substances (PFASs) may increase risk for metabolic diseases; however, epidemiologic evidence is lacking at the present time. Pregnancy is a period of enhanced tissue plasticity for the fetus and the mother and may be a critical window of PFAS exposure susceptibility. OBJECTIVE: We evaluated the associations between PFAS exposures and metabolic outcomes in pregnant women. METHODS: We analyzed 1,240 pregnant women from the Spanish INMA [Environment and Childhood Project (INfancia y Medio Ambiente)] birth cohort study (recruitment period: 2003-2008) with measured first pregnancy trimester plasma concentrations of four PFASs (in nanograms/milliliter)...
November 13, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29135072/measuring-human-placental-blood-flow-with-multidelay-3d-grase-pseudocontinuous-arterial-spin-labeling-at-3t
#8
Xingfeng Shao, Dapeng Liu, Thomas Martin, Teresa Chanlaw, Sherin U Devaskar, Carla Janzen, Aisling M Murphy, Daniel Margolis, Kyunghyun Sung, Danny J J Wang
BACKGROUND: Placenta influences the health of both a woman and her fetus during pregnancy. Maternal blood supply to placenta can be measured noninvasively using arterial spin labeling (ASL). PURPOSE: To present a multidelay pseudocontinuous arterial spin labeling (pCASL) combined with a fast 3D inner-volume gradient- and spin-echo (GRASE) imaging technique to simultaneously measure placental blood flow (PBF) and arterial transit time (ATT), and to study PBF and ATT evolution with gestational age during the second trimester...
November 14, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29134361/sonic-hedgehog-agonist-protects-against-complex-neonatal-cerebellar-injury
#9
Vien Nguyen, Khalida Sabeur, Emin Maltepe, Kurosh Ameri, Omer Bayraktar, David H Rowitch
The cerebellum undergoes rapid growth during the third trimester and is vulnerable to injury and deficient growth in infants born prematurely. Factors associated with preterm cerebellar hypoplasia include chronic lung disease and postnatal glucocorticoid administration. We modeled chronic hypoxemia and glucocorticoid administration in neonatal mice to study whole cerebellar and cell type-specific effects of dual exposure. Chronic neonatal hypoxia resulted in permanent cerebellar hypoplasia. This was compounded by administration of prednisolone as shown by greater volume loss and Purkinje cell death...
November 13, 2017: Cerebellum
https://www.readbyqxmd.com/read/29133984/are-the-timings-and-risk-factors-changing-survival-analysis-of-timing-of-first-antenatal-care-visit-among-pregnant-women-in-nigeria-2003-2013
#10
Adeniyi Francis Fagbamigbe, Baitshephi Mashabe, Lornah Lepetu, Clearance Abel
Background: Child and maternal mortality and morbidity remain among the top global health challenges despite various efforts and multitude of resources directed to improving this situation over time. This study assessed trend of the timings of first antenatal care (ANC) visit in Nigeria and also identified the risk factors associated with it. Methods: The data obtained from three consecutive Nigerian Demographic and Health Surveys in 2003, 2008, and 2013 were pooled...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/29133166/determination-of-threshold-value-for-follow-up-of-isolated-antenatal-hydronephrosis-detected-in-the-second-trimester
#11
Ravi de Roo, Bart J Voskamp, C Emily Kleinrouweler, Ben W Mol, Eva Pajkrt, Antonia H M Bouts
INTRODUCTION: Isolated antenatal hydronephrosis (ANH), defined as a dilation of the renal pelvis (≥5 mm), is one of the most common abnormalities detected on prenatal ultrasound. However, established cut-off values for postnatal follow-up differ between countries and are based on little evidence. The current protocol in the Netherlands for follow-up might be too conservative. OBJECTIVE: To assess the applicability of a higher threshold for follow-up of isolated antenatal hydronephrosis (ANH) than the current practice, without the risk of missing significant postnatal urinary tract obstruction...
June 21, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29133154/adverse-birth-outcomes-associated-with-zika-virus-exposure-during-pregnancy-in-s%C3%A3-o-jos%C3%A3-do-rio-preto-brazil
#12
Mauricio Lacerda Nogueira, Nivison Ruy Rocha Nery Júnior, Cássia Fernanda Estofolete, Ana Carolina Bernardes Terzian, Georgia de Freitas Guimarães, Nathalia Zini, Rafael Alves da Silva, Gislaine Celestino Dutra Silva, Ligia Cosentino Junqueira Franco, Paula Rahal, Cintia Bittar, Bruno Carneiro, Pedro Fernando Vasconcelos da Costa, Daniele Freitas Henriques, Deusenia Machado Ulisses Barbosa, Patrícia Lopes Rombola, Luciana de Grande, Andréia Francesli Negri Reis, Sacha Ariane Palomares, Marcia Wakai Catelan, Lilian Elisa Arão Antonio Cruz, Silvia Helena Necchi, Rita de Cassia Vilella Mendonça, Izalco Nuremberg Penha Dos Santos, Suzimeiri Brigatti Alavarse Caron, Federico Costa, Fernando A Bozza, Antonio Soares de Souza, Cinara Cássia Brandão de Mattos, Luiz Carlos de Mattos, Nikos Vasilakis, Antonio Helio Oliani, Denise Cristina Mós Vaz Oliani, Albert Icksang Ko
OBJECTIVE: We aimed to report the first 54 cases of pregnant women infected by Zika vírus (ZIKV) and their virological and clinical outcomes, as well as the newborns' outcomes in 2016, after the emergence of ZIKV in dengue endemic areas of São Paulo, Brazil. METHODS: This is a descriptive study performed from February to October 2016 on 54 qPCR ZIKV-positive pregnant women identified by the Public Health Authority of São Jose do Rio Preto, São Paulo, Brazil...
November 10, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29133069/relaxin-2-connecting-peptide-pro-rlx2-levels-in-second-trimester-serum-samples-to-predict-preeclampsia
#13
Miriam Rehfeldt, Elizabeth Eklund, Joachim Struck, Andrea Sparwasser, Barbara O'Brien, Glenn E Palomaki, Josef Köhrle, Andreas Bergmann, Geralyn Lambert-Messerlian
OBJECTIVES: Preeclampsia is a serious complication of pregnancy, threatening fetal and maternal health. The aim of our study is to examine the association between preeclampsia and the connecting peptide of the pregnancy hormone relaxin (pro-RLX2) as a potential new biochemical marker. STUDY DESIGN: This is a nested case/control study derived from the cohort of pregnancies delivering at Women & Infants Hospital. Cases were identified at a clinic or by hospital codes, and individually confirmed by record review...
November 7, 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29131362/sex-discordance-identification-following-non-invasive-prenatal-testing
#14
Ebony J Richardson, Fergus P Scott, Andrew C McLennan
OBJECTIVE: To characterize genotype-phenotype discordance identified in the routine clinical setting, and explore the associated diagnostic and counseling challenges. METHOD: Cases were derived from a cohort of pregnant women who attended a multi-site specialist prenatal screening and ultrasound service for non-invasive prenatal testing by cell-free DNA analysis and mid-trimester fetal morphology assessment. RESULTS: Seven cases of genotype-phenotype discordance were identified from a cohort of 12,919 women between June 2013 - March 2017 (incidence 1/1845 pregnancies)...
November 13, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29131096/women-serum-concentrations-of-the-il-10-family-of-cytokines-and-ifn-%C3%AE-decrease-from-the-third-trimester-of-pregnancy-to-active-labor
#15
José Javier Reyes-Lagos, Miguel Ángel Peña-Castillo, Juan Carlos Echeverría, Gilberto Pérez-Sánchez, Samantha Álvarez-Herrera, Enrique Becerril-Villanueva, Lenin Pavón, Rodrigo Ayala-Yáñez, Ramón González-Camarena, Gustavo Pacheco-López
Labor is regarded as increased myometrial activity with a regular contractility pattern. At this final stage of pregnancy, myometrial quiescence is lost, accompanied by altered immune homeostasis. It is well known that the interleukin (IL)-10 family of cytokines modulates immunological responses mainly in epithelial cells, including the endometrium. To investigate their inflammatory profile during labor, we performed a longitudinal study in a group of healthy pregnant women (n = 20) with uncomplicated pregnancies in the third trimester of pregnancy and during active labor...
November 4, 2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29129906/correlation-of-maternal-serum-homocysteine-in-the-first-trimester-with-the-development-of-gestational-hypertension-and-preeclampsia
#16
Feng Sun, Wei Qian, Chen Zhang, Jian-Xia Fan, He-Feng Huang
BACKGROUND This study investigated the relationship of serum homocysteine in early pregnancy with the risk of gestational hypertension (GH) and preeclampsia (PE) and with the severity of preeclampsia. MATERIAL AND METHODS In a retrospective cohort study, we identified 147 confirmed cases of preeclampsia (103 with mild PE and 44 with severe PE) and 147 confirmed cases of GH; 4418 women who remained normotensive and nonproteinuric throughout pregnancy served as controls. Maternal blood samples were collected at between 11 and 13 weeks of gestation to test serum concentrations of homocysteine (Hcy), folic acid, and VitB12...
November 13, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29129777/trichloroethylene-metabolite-s-1-2-dichlorovinyl-l-cysteine-induces-lipid-peroxidation-associated-apoptosis-via-the-intrinsic-and-extrinsic-apoptosis-pathways-in-a-first-trimester-placental-cell-line
#17
Elana R Elkin, Sean M Harris, Rita Loch-Caruso
Trichloroethylene (TCE), a prevalent environmental contaminant, is a potent renal and hepatic toxicant through metabolites such as S-(1, 2-dichlorovinyl)-l-cysteine (DCVC). However, effects of TCE on other target organs such as the placenta have been minimally explored. Because elevated apoptosis and lipid peroxidation in placenta have been observed in pregnancy morbidities involving poor placentation, we evaluated the effects of DCVC exposure on apoptosis and lipid peroxidation in a human extravillous trophoblast cell line, HTR-8/SVneo...
November 9, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29129700/paracetamol-medication-during-pregnancy-insights-on-intake-frequencies-dosages-and-effects-on-hematopoietic-stem-cell-populations-in-cord-blood-from-a-longitudinal-prospective-pregnancy-cohort
#18
Lars Bremer, Janina Goletzke, Christian Wiessner, Mirja Pagenkemper, Christina Gehbauer, Heiko Becher, Eva Tolosa, Kurt Hecher, Petra C Arck, Anke Diemert, Gisa Tiegs
BACKGROUND: Paracetamol is the first choice for antipyretic or analgesic treatment throughout pregnancy. Products with Paracetamol are readily available over the counter and therefore easily accessible for self-medication. Epidemiological data on Paracetamol intake pattern during pregnancy and its potential immunological effects are sparse. We aimed to analyze a possible association between Paracetamol medication and numbers of hematopoietic stem cells (HSC) in cord blood. METHODS: The objective was addressed in the PRINCE (PRENATAL DETERMINANTS OF CHILDREN'S HEALTH) study, a population-based prospective pregnancy cohort study initiated in 2011 at the University Medical Center in Hamburg, Germany...
November 9, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29129541/weight-gain-in-early-pregnancy-and-risk-of-gestational-diabetes-mellitus-among-latinas
#19
T A Moore Simas, M E Waring, K Callaghan, K Leung, M Ward Harvey, A Buabbud, L Chasan-Taber
AIM: To evaluate the association between gestational weight gain (GWG) in early pregnancy and incidence of abnormal glucose tolerance (AGT) and gestational diabetes mellitus (GDM) among Latinas. METHODS: We conducted a retrospective cohort study of 2039 Latinas using pooled data from two medical centres in Massachusetts. Gestational weights were abstracted from medical records and GWG was categorized as low, appropriate and excessive according to 2009 Institute of Medicine Guidelines...
November 9, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29129159/third-trimester-ultrasound-accuracy-and-delivery-outcome-in-obese-and-morbid-obese-pregnant-women
#20
Sawsan Al-Obaidly, Abdullah Al-Ibrahim, Najah Saleh, Mariam Al-Belushi, Zeena Al-Mansouri, Najat Khenyab
OBJECTIVE: Several studies have highlighted the negative impact of maternal obesity on ultrasound accuracy for fetal weight estimation (EFW). However, the evidence is conflicting. We aimed in our study to find if the ultrasound accuracy for fetal weight estimation would differ or decrease in obese and morbid obesity classes. In addition to study the mode of delivery within the same cohort. METHODS: It's a retrospective study of obese patients with recorded BMI ≥ 30 kg/m(2), class I and II (BMI 30-39...
November 12, 2017: Journal of Maternal-fetal & Neonatal Medicine
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