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https://www.readbyqxmd.com/read/27921458/metabolic-profile-of-human-coelomic-fluid
#1
C Virgiliou, L Valianou, M Witting, F Moritz, C Fotakis, P Zoumpoulakis, A C Chatziioannou, L Lazaros, G Makrydimas, K Chatzimeletiou, N Raikos, G A Theodoridis
AIM: Till now there is very limited knowledge on the molecular content of coelomic fluid and cells. This study presents the first attempt to elucidate the metabolic profile of such samples. METHODOLOGY: Samples were collected via coelocentesis from 41 women during the first trimester of gestation. Metabolic content was assessed using four different analytical platforms. For targeted analysis a hydrophilic interaction chromatography ultra high performance LC-MS/MS method was applied...
January 2017: Bioanalysis
https://www.readbyqxmd.com/read/27921088/intra-uterine-extra-amniotic-versus-vaginal-misoprostol-for-termination-of-second-trimester-miscarriage-a-randomized-controlled-trial
#2
Abo Bakr Abbas Mitwaly, Ahmed Mohamed Abbas, Mohamed Sayed Abdellah
BACKGROUND: Termination of pregnancy in the second trimester using prostaglandins has been shown to be safe and effective. Misoprostol has multiple routes of administration; oral, vaginal, buccal, rectal and sublingual. OBJECTIVE: The study aims to compare the efficacy and safety of intrauterine extra-amniotic and vaginal misoprostol in a dose of 200 microgram every 4 hours for the termination of pregnancy in cases of second trimester miscarriage. MATERIALS AND METHODS: A prospective randomized open labeled clinical trial included 180 women with missed miscarriage in gestational age between 13 and 24 wks...
October 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27921004/a-rare-case-of-gestational-gigantomastia-with-hypercalcemia-the-challenges-of-management-and-follow-up
#3
Bahram Moazzami, Shahla Chaichian, Mohammad Reza Farahvash, Saeedeh Taheri, Seyed Ali Ahmadi, Majid Mokhtari, Kourosh Sheibani
BACKGROUND: Gigantomastia is a breast disorder marked by exaggerated rapid growth of the breasts, generally bilaterally. Since this disorder is very rare and has been reported only in sparse case reports its etiology has yet to be fully established. Treatment is aimed at improving the clinical and psychological symptoms and reducing the treatment side effects; however, the best therapeutic option varies from case to case. CASE PRESENTATION: The present report described a case of gestational gigantomastia in a 30-year-old woman, gravida 2, parity 1, 17 week pregnant admitted to Pars Hospital, Tehran, Iran, on May 2014...
October 2016: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/27920084/caffeine-consumption-during-pregnancy-and-adhd-at-the-age-of-11%C3%A2-years-a-birth-cohort-study
#4
Bianca Del-Ponte, Iná S Santos, Luciana Tovo-Rodrigues, Luciana Anselmi, Tiago N Munhoz, Alicia Matijasevich
OBJECTIVE: Studies evaluating caffeine intake during pregnancy and long-term outcomes, such as the child's neurobehaviour, are still scarce and their results are inconsistent. The objective of the present study was to evaluate the association between maternal consumption of caffeine during pregnancy and attention deficit hyperactivity disorder (ADHD) at the age of 11 years. METHODOLOGY: All children born in the city of Pelotas, Brazil, during the year 2004, were selected for a cohort study...
December 5, 2016: BMJ Open
https://www.readbyqxmd.com/read/27919989/teratogenic-effect-of-radotinib-case-report
#5
Juyoung Cheon, Jung Whan Ahn, Kyung Min Park, Guisera Lee, Yun Sung Jo
BACKGROUND: Simultaneous presentation of pregnancy and chronic myeloid leukemia (CML) is rare. Tyrosine kinase inhibitors (TKIs) are rarely used in pregnancy. There is almost no information on the effect of recently developed TKIs on the fetus. CASE REPORT: A 22-year-old woman became pregnant while using radotinib, a novel TKI for CML. She was concerned about the possible teratogenic effect of radotinib; hence the first pregnancy was terminated. The patient underwent full-term delivery at the second pregnancy...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27919602/hematocrit-and-plasma-albumin-levels-difference-may-be-a-potential-biomarker-to-discriminate-preeclampsia-and-eclampsia-in-patients-with-hypertensive-disorders-of-pregnancy
#6
Dong-Mei Dai, Jing Cao, Hong-Mei Yang, Hai-Mei Sun, Yu Su, Yuan-Yuan Chen, Xiao Fang, Wang-Bin Xu
BACKGROUND: We evaluated whether alterations of hemoglobin (HB), hematocrit (HCT), serum albumin level (ALB), and the difference of HCT and ALB can be used in the diagnosis of preeclampsia and eclampsia in patients with hypertensive disorders of pregnancy (HDP). METHODS: A total of 509 individuals were recruited and divided into 4 groups: Group 1, 170 healthy non-pregnant women; Group 2, 125 normal pregnant women; Group 3, 105 pregnant women diagnosed with gestational and chronic hypertension; Group 4, 109 pregnant women diagnosed as having preeclampsia and eclampsia...
December 2, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27919543/maternal-plasma-polyunsaturated-fatty-acid-levels-during-pregnancy-and-childhood-lipid-and-insulin-levels
#7
A J Vidakovic, V W V Jaddoe, T Voortman, H Demmelmair, B Koletzko, R Gaillard
BACKGROUND AND AIMS: Maternal polyunsaturated fatty acid (PUFA) levels are associated with cord blood lipid and insulin levels. Not much is known about the influence of maternal PUFAs during pregnancy on long-term offspring lipid and insulin metabolism. We examined the associations of maternal plasma n-3 and n-6 PUFA levels during pregnancy with childhood lipid and insulin levels. METHODS AND RESULTS: In a population-based prospective cohort study, among 3230 mothers and their children, we measured maternal second trimester n-3 and n-6 PUFA plasma levels...
October 12, 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/27919147/-the-iodine-intake-in-a-female-population-of-an-apennine-valley-italy-in-years-2003-2013
#8
Giulio Ozzola, Lucia Gasbarri, Carlo Montaini
OBJECTIVES: to assess if the iodine intake of pregnant women had increased or not after the introduction of Law no. 55 of March 2005 («Provisions aimed at the prevention of endemic goitre and other diseases from iodine deficiency») and if it reached the levels recommended by the World Health Organisation (WHO). DESIGN: evaluation of ioduria values in the female local population enrolled. SETTING AND PARTICIPANTS: in 4 different years, 100 women per year (400 women in all) were enrolled in this study...
November 2016: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/27919059/role-of-maternal-occupational-physical-activity-and-psychosocial-stressors-on-adverse-birth-outcomes
#9
Laura J Lee, Elaine Symanski, Philip J Lupo, Sarah C Tinker, Hilda Razzaghi, Wenyaw Chan, Adrienne T Hoyt, Mark A Canfield
OBJECTIVES: We examined the association of an array of estimated maternal occupational physical activities and psychosocial stressors during pregnancy with odds for preterm birth (PTB) and small-for-gestational age (SGA). METHODS: Data for infants born without major birth defects delivered from 1997 to 2009 whose mothers reported working at least 1 month during pregnancy were obtained from the National Birth Defects Prevention Study. We linked occupational codes to the US Department of Labor's Occupational Information Network, which provides estimates of exposure for multiple domains of physical activity and psychosocial stressors by occupational categories...
October 6, 2016: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27918616/nitric-oxide-donors-for-cervical-ripening-and-induction-of-labour
#10
REVIEW
Arpita Ghosh, Katherine R Lattey, Anthony J Kelly
BACKGROUND: Sometimes it is necessary to bring on labour artificially because of safety concerns for the mother or baby. This review is one of a series of reviews of methods of labour induction using a standardised protocol. OBJECTIVES: To determine the effects of NO donors (isosorbide mononitrate (ISMN), isosorbide dinitrate (ISDN), nitroglycerin and sodium nitroprusside) for third trimester cervical ripening or induction of labour, in comparison with placebo or no treatment or other treatments from a predefined hierarchy...
December 5, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27917879/colonic-luminal-microbiota-and-bacterial-metabolite-composition-in-pregnant-huanjiang-mini-pigs-effects-of-food-composition-at-different-times-of-pregnancy
#11
Xiang-Feng Kong, Yu-Jiao Ji, Hua-Wei Li, Qian Zhu, F Blachier, Mei-Mei Geng, Wen Chen, Yu-Long Yin
The gut harbours diverse and complex microbiota, which influence body health including nutrient metabolism, immune development, and protection from pathogens. Pregnancy is associated with immune and metabolic changes that might be related to microbiota compositional dynamics. We therefore investigated the colonic luminal bacteria community in Huanjiang mini-pigs fed diets with different nutrient levels from the first to third trimester of pregnancy. The concentrations of intestinal metabolites including short-chain fat acids, NH3-N, indole, skatole, and bioamines were also determined...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27916927/vitamin-b12-status-among-pregnant-women-in-the-uk-and-its-association-with-obesity-and-gestational-diabetes
#12
Nithya Sukumar, Hema Venkataraman, Sean Wilson, Ilona Goljan, Selvin Selvamoni, Vinod Patel, Ponnusamy Saravanan
BACKGROUND: To evaluate vitamin B12 and folate status in pregnancy and their relationship with maternal obesity, gestational diabetes mellitus (GDM), and offspring birthweight. METHODS: A retrospective case-control study of 344 women (143 GDM, 201 no-GDM) attending a district general hospital and that had B12 and folate levels measured in the early 3rd trimester was performed. Maternal history including early pregnancy body mass index (BMI) and neonatal data (birthweight, sex, and gestational age) was recorded for all subjects...
December 1, 2016: Nutrients
https://www.readbyqxmd.com/read/27916508/development-of-gestation-specific-reference-intervals-for-thyroid-hormones-in-normal-pregnant-northeast-chinese-women-what-is-the-rational-division-of-gestation-stages-for-establishing-reference-intervals-for-pregnancy-women
#13
Jianhua Liu, Xiaojun Yu, Meng Xia, Hong Cai, Guixue Cheng, Lina Wu, Qiang Li, Ying Zhang, Mengyuan Sheng, Yong Liu, Xiaosong Qin
BACKGROUND: A laboratory- and region-specific trimester-related reference interval for thyroid hormone assessment of pregnant women were recommended. Whether the division by trimester is suitable requires verification. Here, we tried to establish appropriate reference intervals of thyroid-related hormones and antibodies for normal pregnant women in Northeast China. METHODS: A total of 947 pregnant women who underwent routine prenatal care were grouped via two methods...
December 1, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27916501/association-between-iron-level-glucose-impairment-and-increased-dna-damage-during-pregnancy
#14
Salam Zein, Samar Rachidi, Nadine Shami, Iman Sharara, Khawla Cheikh-Ali, Anne-Sophie Gauchez, Jean-Marc Moulis, Jean-Marc Ayoubi, Pascale Salameh, Isabelle Hininger-Favier
: Elevated circulating ferritin has been reported to increase the risk of gestational diabetes mellitus (GDM). When high ferritin translates into high iron stores, iron excess is also a condition leading to free radical damage. We aimed to evaluate the relationship between oxidative stress (OS) induced by iron status and GDM risk in non iron-supplemented pregnant women. METHODS: This was a pilot observational study conducted on 93 non-anemic pregnant women. Iron status was assessed at the first trimester of gestation...
November 18, 2016: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27915499/first-trimester-contingent-screening-for-trisomies-21-18-13-is-this-model-cost-efficient-and-feasible-in-pubblic-health-system
#15
Enrico Colosi, Valentina D'Ambrosio, Enrico Periti
PURPOSE: To evaluate the effectiveness of three different first trimester screening models for trisomies 21, 18 and 13, in terms of detection rate, invasive test rate and final costs. MATERIAL AND METHODS: We analyzed the distribution of risk for trisomies 21, 18 and 13 in a population of 20.831 singleton pregnancies based on maternal age, fetal heart rate, nuchal translucency, free beta human chorionic gonadotropin and pregnancy associated plasma protein A (Combined test)...
December 5, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27915496/cervical-pessary-for-preventing-preterm-birth-in-twin-pregnancies-with-short-cervical-length-a-systematic-review-and-meta-analysis
#16
Gabriele Saccone, Andrea Ciardulli, Serena Xodo, Lorraine Dugoff, Jack Ludmir, Francesco D'Antonio, Simona Boito, Elena Olearo, Carmela Votino, Giuseppe Maria Maruotti, Giuseppe Rizzo, Pasquale Martinelli, Vincenzo Berghella
OBJECTIVE: To evaluate the effectiveness of cervical pessary for preventing spontaneous preterm birth (SPTB) in twin pregnancies with an asymptomatic transvaginal ultrasound cervical length (TVU CL) in the second trimester Methods: We performed a meta-analysis including all randomized clinical trials (RCTs) comparing the use of cervical pessary (i.e. intervention group) with expectant management (i.e. control group). The primary outcome was incidence of SPTB <34 weeks. RESULTS: Three trials, including 481 twin pregnancies with short cervix, were analyzed...
December 5, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27914249/fewer-self-reported-depressive-symptoms-in-young-adults-exposed-to-maternal-depressed-mood-during-pregnancy
#17
Katrin Zohsel, Nathalie E Holz, Erika Hohm, Martin H Schmidt, Günter Esser, Daniel Brandeis, Tobias Banaschewski, Manfred Laucht
BACKGROUND: Depressed mood is prevalent during pregnancy, with accumulating evidence suggesting an impact on developmental outcome in the offspring. However, the long-term effects of prenatal maternal depression regarding internalizing psychopathology in the offspring are as yet unclear. METHODS: As part of an ongoing epidemiological cohort study, prenatal maternal depressed mood was assessed at the child's age of 3 months. In a sample of n=307 offspring, depressive symptoms were obtained via questionnaire at the ages of 19, 22, 23 and 25 years...
October 11, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27914245/perinatal-hypothalamic-pituitary-adrenal-axis-regulation-among-women-with-eating-disorders-and-their-infants
#18
A Easter, E Taborelli, A Bye, P A Zunszain, C M Pariante, J Treasure, U Schmidt, N Micali
BACKGROUND: Psychiatric illness is associated with heightened hypothalamic-pituitary-adrenal (HPA) axis activity during pregnancy which may have long term effects on infant stress regulation. HPA axis regulation has not previously been investigated in women with eating disorders (ED) or their infants during the perinatal period. METHODS: Women were recruited to a prospective longitudinal study in three groups: 1) current or active ED (C-ED=31), 2) past ED (P-ED=29) and healthy control (HC=57)...
November 11, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27914182/positive-feelings-during-pregnancy-early-feeding-practices-and-infant-health
#19
Melissa A McManus, Ali A Khalessi, Joyce Lin, Jahanzeb Ashraf, Stephanie M Reich
BACKGROUND: Early parenting practices, like infant feeding, can impact children's physical health. Additionally, negative prenatal maternal affect can influence feeding choices, like breastfeeding, and can have a detrimental effect on children's health. However, little is known about the contribution of positive maternal affect during pregnancy on feeding practices and children's health. METHOD: This study explored whether positive prenatal feelings influenced children's health during the first 18 months, and whether early feeding practices mediated the relationship between these two variables...
December 3, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27913926/maxillary-length-in-euploid-and-aneuploid-fetuses
#20
Markus Hoopmann, Jiri Sonek, Dominik Goldschmid, Philipp Wagner, Harald Abele, Karl Oliver Kagan
PURPOSE: To examine the maxillary length of euploid and aneuploid fetuses in the second and third trimester. METHODS: Retrospective study utilizing stored 2D images of second and third trimester fetal profiles obtained at the University of Tuebingen, Germany. The length of the maxilla was measured as a straight line between the anterior ventral and posterior ventral edges of the maxilla. RESULTS: The study population consisted of 347 euploid fetuses and 122, 36, 5, 8, and 4 fetuses with trisomy 21, 18, and 13, Turner syndrome, and triploidy...
December 2, 2016: Archives of Gynecology and Obstetrics
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