Zhihua Yi, Shuai Ouyang, Congfa Zhou, Lihui Xie, Zhi Fang, Huilong Yuan, Jinpu Yang, Lifang Zou, Tianyu Jia, Shanhong Zhao, Lin Li, Liran Shi, Yun Gao, Guilin Li, Shuangmei Liu, Hong Xu, Changshui Xu, Chunping Zhang, Shangdong Liang
Aim: In this study, we investigated whether andrographolide (Andro) can alleviate neuropathic pain induced by HIV gp120 plus ddC treatment and the mechanism of its action. Methods: The paw withdrawal threshold and the paw withdrawal latency were observed to assess pain behaviors in all groups of the rats, including control group, control combined with Andro treatment group, sham group, gp120 combined with ddC treatment group, gp120 plus ddC combined with A438079 treatment group, and gp120 plus ddC combined with Andro treatment by intrathecally injecting at a dose of 25 μg/20 μl group...
2018: Frontiers in Pharmacology