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https://www.readbyqxmd.com/read/28934795/comparisons-of-lesion-volumes-and-shapes-produced-by-a-radiofrequency-system-with-a-cooled-a-protruding-or-a-monopolar-probe
#1
David L Cedeno, Alejandro Vallejo, Courtney A Kelley, Dana M Tilley, Nitesh Kumar
BACKGROUND: Radiofrequency (RF) ablation for denervation has been utilized for decades in chronic pain management. This relies on the proper targeting of the affected nerve which may be obtained by creating an ablation lesion with a shape and volume that optimizes targeting. Various systems designed to improve lesion size are available. These include cooling the active tip (cooled-RF) and protruding the RF electrode outside the active tip (PERF). OBJECTIVES: This study compares lesion volumes of 3 commercially available RF systems: cooled-RF, "V" shaped active cannula and protruding electrode (18 g and 20 g), and monopolar RF (MRF; 16 g, 18 g, and 20 g)...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28934501/model-based-design-of-rna-hybridization-networks-implemented-in-living-cells
#2
Guillermo Rodrigo, Satya Prakash, Shensi Shen, Eszter Majer, José-Antonio Daròs, Alfonso Jaramillo
Synthetic gene circuits allow the behavior of living cells to be reprogrammed, and non-coding small RNAs (sRNAs) are increasingly being used as programmable regulators of gene expression. However, sRNAs (natural or synthetic) are generally used to regulate single target genes, while complex dynamic behaviors would require networks of sRNAs regulating each other. Here, we report a strategy for implementing such networks that exploits hybridization reactions carried out exclusively by multifaceted sRNAs that are both targets of and triggers for other sRNAs...
September 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28934484/regulation-of-hur-structure-and-function-by-dihydrotanshinone-i
#3
Preet Lal, Linda Cerofolini, Vito Giuseppe D'Agostino, Chiara Zucal, Carmelo Fuccio, Isabelle Bonomo, Erik Dassi, Stefano Giuntini, Danilo Di Maio, Vikalp Vishwakarma, Ranjan Preet, Sha Neisha Williams, Max S Fairlamb, Rachel Munk, Elin Lehrmann, Kotb Abdelmohsen, Saioa R Elezgarai, Claudio Luchinat, Ettore Novellino, Alessandro Quattrone, Emiliano Biasini, Leonardo Manzoni, Myriam Gorospe, Dan A Dixon, Pierfausto Seneci, Luciana Marinelli, Marco Fragai, Alessandro Provenzani
The Human antigen R protein (HuR) is an RNA-binding protein that recognizes U/AU-rich elements in diverse RNAs through two RNA-recognition motifs, RRM1 and RRM2, and post-transcriptionally regulates the fate of target RNAs. The natural product dihydrotanshinone-I (DHTS) prevents the association of HuR and target RNAs in vitro and in cultured cells by interfering with the binding of HuR to RNA. Here, we report the structural determinants of the interaction between DHTS and HuR and the impact of DHTS on HuR binding to target mRNAs transcriptome-wide...
September 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28934283/grading-of-invasive-breast-carcinoma-through-grassmannian-vlad-encoding
#4
Kosmas Dimitropoulos, Panagiotis Barmpoutis, Christina Zioga, Athanasios Kamas, Kalliopi Patsiaoura, Nikos Grammalidis
In this paper we address the problem of automated grading of invasive breast carcinoma through the encoding of histological images as VLAD (Vector of Locally Aggregated Descriptors) representations on the Grassmann manifold. The proposed method considers each image as a set of multidimensional spatially-evolving signals that can be efficiently modeled through a higher-order linear dynamical systems analysis. Subsequently, each H&E (Hematoxylin and Eosin) stained breast cancer histological image is represented as a cloud of points on the Grassmann manifold, while a vector representation approach is applied aiming to aggregate the Grassmannian points based on a locality criterion on the manifold...
2017: PloS One
https://www.readbyqxmd.com/read/28934258/reports-of-unintended-consequences-of-financial-incentives-to-improve-management-of-hypertension
#5
Sylvia J Hysong, Richard SoRelle, Kristen Broussard Smitham, Laura A Petersen
BACKGROUND: Given the increase in financial-incentive programs nationwide, many physicians and physician groups are concerned about potential unintended consequences of providing financial incentives to improve quality of care. However, few studies examine whether actual unintended consequences result from providing financial incentives to physicians. We sought to document the extent to which the unintended consequences discussed in the literature were observable in a randomized clinical trial (RCT) of financial incentives...
2017: PloS One
https://www.readbyqxmd.com/read/28934134/ferrocene-molecular-architectures-grafted-on-si-111-a-theoretical-calculation-of-the-standard-oxidation-potentials-and-electron-transfer-rate-constant
#6
Claudio Fontanesi, Massimo Innocenti, Davide Vanossi, Enrico Da Como
The standard oxidation potential and the electron transfer (ET) rate constants of two silicon-based hybrid interfaces, Si(111)/organic-spacer/Ferrocene, are theoretically calculated and assessed. The dynamics of the electrochemical driven ET process is modeled in terms of the classical donor/acceptor scheme within the framework of "Marcus theory". The ET rate constants, k E T , are determined following calculation of the electron transfer matrix element, V R P , together with the knowledge of the energy of the neutral and charge separated systems...
September 21, 2017: Materials
https://www.readbyqxmd.com/read/28933862/creim-coffee-ring-effect-imaging-model-for-monitoring-protein-self-assembly-in-situ
#7
Michael Shaw, Angelo Bella, Maxim G Ryadnov
Protein self-assembly is fundamental to nanotechnology. Self-assembling structures are produced under static in vitro conditions typically forming over hours. In contrast, hydrodynamic intra-cellular environments employ far shorter timescales to compartmentalize highly concentrated protein solutions. Herein, we exploit the radial capillary flow within a drying sessile droplet (the coffee ring effect) to emulate dynamic native environments and monitor an archetypal protein assembly in situ using high-speed super-resolution imaging...
September 21, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28933854/epigenetic-dna-modification-n6-methyladenine-causes-site-specific-rna-polymerase-ii-transcriptional-pausing
#8
Wei Wang, Liang Xu, Lulu Hu, Jenny Chong, Chuan He, Dong Wang
N6-methyladenine (N6-mA or 6mA) is an epigenetic DNA modification in eukaryotic genomes. In contrast to the well-established roles of 5-methylcytosine for epigenetic regulation of gene expression, the functional roles of N6-mA remain elusive. In particular, the impact of N6-mA modification at DNA template on RNA polymerase II (pol II) transcription elongation is not known. In this work, using the Saccharomyces cerevisiae pol II transcriptional elongation system as a model, we investigated the molecular mechanism of pol II recognition and processing of N6-mA sites via both biochemical and structural approaches...
September 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28933839/flexible-and-comprehensive-implementation-of-md-pmm-approach-in-a-general-and-robust-code
#9
Oliver Carrillo-Parramon, Sara Del Galdo, Massimiliano Aschi, Giordano Mancini, Andrea Amadei, Vincenzo Barone
The Perturbed Matrix Method (PMM) approach to be used in combination with Molecular Dynamics (MD) trajectories (MD-PMM) has been recoded from scratch, improved in several aspects, and implemented in the Gaussian suite of programs for allowing user friendly and yet flexible tool to estimate quantum chemistry observables in complex systems in condensed phases. Particular attention has been devoted to a description of rigid and flexible quantum centers together with powerful essential dynamics and clustering approaches...
September 21, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28933829/synthesis-crystal-structure-and-magnetic-properties-of-the-highly-frustrated-orthorhombic-li4mgreo6
#10
JoAnna Milam-Guerrero, Charles J Bloed, Phuong-Hieu T Nguyen, Gia T Tran, William P Martin, Demetrios V Papakostas, Jefferson Toro, Murray N Wilson, Jeremy P Carlo, Graeme M Luke, Brent C Melot, Jiyeong Gu, Shahab Derakhshan
In an effort to understand the structure-property relationship in magnetically frustrated systems, an orthorhombic analog of the S = 1/2 Re-based oxide Li4MgReO6 has been successfully synthesized and its physical properties were investigated. Li4MgReO6 had been previously synthesized in a monoclinic system in an ordered NaCl structure type. That system was shown to exhibit spin glass behavior below ∼12 K. The crystal structure of the latter phase was determined using powder X-ray diffraction data. A structural model was refined in the orthorhombic Fddd space group that resulted in cell dimensions of a = 5...
September 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28933822/rod-like-virus-based-multiarm-colloidal-molecules
#11
Alexis de la Cotte, Cheng Wu, Marie Trévisan, Andrii Repula, Eric Grelet
We report on the construction of multiarm colloidal molecules by tip-linking filamentous bacteriophages, functionalized either by biological engineering or chemical conjugation. The affinity for streptavidin of a genetically modified vector phage displaying Strep-tags fused to one end of the viral particle, is measured by determining the dissociation constant, Kd. In order to both improve the colloidal stability and the efficiency of the self-assembly process, a biotinylation protocol having a chemical yield higher than 90% is presented to regio-selectively functionalize the cystein residues located at one end of the bacteriophages...
September 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/28933661/suppressing-allostery-in-epitope-mapping-experiments-using-millisecond-hydrogen-deuterium-exchange-mass-spectrometry
#12
Bin Deng, Shaolong Zhu, Andrew M Macklin, Jianrong Xu, Cristina Lento, Adnan Sljoka, Derek J Wilson
Localization of the interface between the candidate antibody and its antigen target, commonly known as epitope mapping, is a critical component of the development of therapeutic monoclonal antibodies. With the recent availability of commercial automated systems, hydrogen / deuterium eXchange (HDX) is rapidly becoming the tool for mapping epitopes preferred by researchers in both industry and academia. However, this approach has a significant drawback in that it can be confounded by 'allosteric' structural and dynamic changes that result from the interaction, but occur far from the point(s) of contact...
September 21, 2017: MAbs
https://www.readbyqxmd.com/read/28933649/legionella-blocks-autophagy-by-cleaving-stx17-syntaxin-17
#13
Kohei Arasaki, Mitsuo Tagaya
Pathogens subvert host defense systems including autophagy and apoptosis for their survival and proliferation. Legionella pneumophila is a Gram-negative bacterium that grows in alveolar macrophages and causes severe pneumonia. Early during infection Legionella secretes effector proteins that convert the plasma membrane-derived vacuole containing Legionella into an endoplasmic reticulum (ER)-like replicative vacuole. These vacuoles ultimately fuse with the ER, where the pathogen replicates. Recently, we showed that one of the effectors, Lpg1137, is a serine protease that targets the mitochondria-associated ER membrane (MAM) and degrades STX17 (syntaxin 17), a SNARE implicated in macroautophagy/autophagy as well as mitochondria dynamics and membrane trafficking in fed cells...
September 21, 2017: Autophagy
https://www.readbyqxmd.com/read/28933482/structure-and-lifetimes-in-ionic-liquids-and-their-mixtures
#14
Sascha Gehrke, Michael von Domaros, Ryan Clark, Oldamur Hollóczki, Martin Brehm, Tom Welton, Alenka Luzar, Barbara Kirchner
With the aid of molecular dynamics simulations, we study the structure and dynamics of different ionic liquid systems, with focus on hydrogen bond, ion pair and ion cage formation. To do so, we report radial distribution functions, their number integrals, and various time-correlation functions, from which we extract well-defined lifetimes by means of the reactive flux formalism. We explore the influence of polarizable force fields vs. non-polarizable ones with downscaled charges (±0.8) for the example of 1-butyl-3-methylimidazolium bromide...
September 21, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28933479/linking-classical-and-molecular-optomechanics-descriptions-of-sers
#15
Mikołaj K Schmidt, Ruben Esteban, Felix Benz, Jeremy J Baumberg, Javier Aizpurua
The surface-enhanced Raman scattering (SERS) of molecular species in plasmonic cavities can be described as an optomechanical process where plasmons constitute an optical cavity of reduced effective mode volume which effectively couples to the vibrations of the molecules. An optomechanical Hamiltonian can address the full quantum dynamics of the system, including the phonon population build-up, the vibrational pumping regime, and the Stokes-anti-Stokes correlations of the photons emitted. Here we describe in detail two different levels of approximation to the methodological solution of the optomechanical Hamiltonian of a generic SERS configuration, and compare the results of each model in light of recent experiments...
September 21, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28933439/3d-printing-of-high-strength-aluminium-alloys
#16
John H Martin, Brennan D Yahata, Jacob M Hundley, Justin A Mayer, Tobias A Schaedler, Tresa M Pollock
Metal-based additive manufacturing, or three-dimensional (3D) printing, is a potentially disruptive technology across multiple industries, including the aerospace, biomedical and automotive industries. Building up metal components layer by layer increases design freedom and manufacturing flexibility, thereby enabling complex geometries, increased product customization and shorter time to market, while eliminating traditional economy-of-scale constraints. However, currently only a few alloys, the most relevant being AlSi10Mg, TiAl6V4, CoCr and Inconel 718, can be reliably printed; the vast majority of the more than 5,500 alloys in use today cannot be additively manufactured because the melting and solidification dynamics during the printing process lead to intolerable microstructures with large columnar grains and periodic cracks...
September 20, 2017: Nature
https://www.readbyqxmd.com/read/28932956/time-lapse-imaging-provides-further-evidence-that-planar-arrangement-of-blastomeres-is-highly-abnormal
#17
Thomas Ebner, Alexandra Höggerl, Peter Oppelt, Elisabeth Radler, Simon-Hermann Enzelsberger, Richard B Mayer, Erwin Petek, Omar Shebl
PURPOSE: Recently, guidelines on the annotation of dynamic human embryo monitoring recommended screening for the presence of planar blastomere arrangement at the 4-cell stage. This observational study was set up in order to analyze whether developmental kinetics of planar human embryos are different from tetrahedral ones. METHODS: Therefore, embryos of 115 consecutive ICSI patients (showing 32 planar and 554 tetrahedral embryos) were cultured in a new time-lapse system (Miri TL) and their embryos were annotated for morphokinetic development and screened for irregular cleavages and morphological dysmorphisms...
September 20, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28932849/new-insights-into-single-compound-and-binary-adsorption-of-copper-and-lead-ions-on-a-treated-sea-mango-shell-experimental-and-theoretical-studies
#18
Lotfi Sellaoui, Felycia Edi Soetaredjo, Suryadi Ismadji, Éder Cláudio Lima, Guilherme L Dotto, Abdelmottaleb Ben Lamine, Alessandro Erto
Herein, adsorption isotherms of Pb(ii) and Cu(ii) ions on treated sea mango fruit in both single-compound and binary systems were experimentally realized at different temperatures in the range of 30-50 °C. Experimental results show that adsorption of Pb(ii) was more as compared to that of Cu(ii) ions; however, for both ions, a significant reduction in the adsorption capacity was observed in the binary system as compared to that in the single-compound systems. Moreover, under all the investigated conditions, adsorption seems to be promoted by an increase in temperature...
September 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28932826/interobserver-variation-of-the-bolus-and-burst-method-for-pancreatic-perfusion-with-dynamic-contrast-enhanced-ultrasound
#19
Marcus Stangeland, Trond Engjom, Martin Mezl, Radovan Jirik, Odd Helge Gilja, Georg Dimcevski, Kim Nylund
PURPOSE: Dynamic contrast-enhanced ultrasound (DCE-US) can be used for calculating organ perfusion. By combining bolus injection with burst replenishment, the actual mean transit time (MTT) can be estimated. Blood volume (BV) can be obtained by scaling the data to a vessel on the imaging plane. The study aim was to test interobserver agreement for repeated recordings using the same ultrasound scanner and agreement between results on two different scanner systems. MATERIALS AND METHODS: Ten patients under evaluation for exocrine pancreatic failure were included...
June 2017: Ultrasound International Open
https://www.readbyqxmd.com/read/28932753/effect-of-iop-based-infusion-system-with-and-without-balanced-phaco-tip-on-cumulative-dissipated-energy-and-estimated-fluid-usage-in-comparison-to-gravity-fed-infusion-in-torsional-phacoemulsification
#20
Praveen K Malik, Taru Dewan, Arun Kr Patidar, Ekta Sain
BACKGROUND: To evaluate the effect of three different combinations of tip designs and infusion systems in torsional phacoemulsification (INFINITI and CENTURION) in patients with cataract. According to the manufacturer, two unique improvements in the Centurion are: active fluid dynamic management system and use of an intrepid balanced tip. The study specifically aimed to evaluate the beneficial effects, if any, of change in tip design and infusion system individually and in combination on both per-operative parameters as well as endothelial health over 6 months...
2017: Eye and Vision (London, England)
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