keyword
MENU ▼
Read by QxMD icon Read
search

Scarring

keyword
https://www.readbyqxmd.com/read/27911123/lichen-sclerosus-et-atrophicus-in-a-surgical-scar-treated-with-fractional-laser
#1
Marta Mendieta Eckert, Izaskun Ocerin Guerra, Nerea Landa Gundin
Lichen sclerosus et atrophicus (LSA) is a chronic inflammatory disease of unknown cause that typically affects the genital area(1). It has been reported in post-traumatic areas as a result of Koebner´s phenomenon. LSA responds poorly to treatment making it a therapeutic challenge(2). Laser therapy has been described for LSA with variable results(3,4).
December 2, 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/27911032/a-dermal-equivalent-engineered-with-tgf-%C3%AE-3-expressing-bone-marrow-stromal-cells-and-amniotic-membrane-cosmetic-healing-of-full-thickness-skin-wounds-in-rats
#2
Ali Samadikuchaksaraei, Ahmad Mehdipour, Mehryar Habibi Roudkenar, Javad Verdi, Mohammad Taghi Joghataei, Kamran As'adi, Fatemeh Amiri, Mozhgan Dehghan Harati, Mazaher Gholipourmalekabadi, Nushin Karkuki Osguei
Transforming growth factor beta-3 (TGF-β3) has been shown to decrease scar formation after scheduled topical applications to the cutaneous wounds. This study aimed to continuously deliver TGF-β3, during the early phase of wound healing, by engineering a dermal equivalent (DE) using TGF-β3 expressing bone marrow stromal cells (BM-SCs) and human dehydrated amniotic membrane (hDAM). To engineer a DE, rat BM-SCs were seeded on the hDAM and TGF-β3 was transiently transfected into the BM-SCs using a plasmid vector...
December 2016: Artificial Organs
https://www.readbyqxmd.com/read/27910059/gene-therapy-for-post-infarction-ventricular-tachycardia
#3
J Kevin Donahue
Cardiac arrhythmias are a leading cause of morbidity and mortality in the developed world. In particular, cardiac arrest or sudden cardiac death is the leading cause of death in these countries. Death generally results from a ventricular tachyarrhythmia, and pathology data have shown that cardiac arrest victims very frequently have evidence of coronary atherosclerosis with either acute ischemia or healed myocardial infarction. In this work, we describe an animal model that reproducibly has inducible ventricular tachyarrhythmias after healing of a myocardial infarction scar and a gene delivery method that allows gene transfer to the scar and surrounding myocardial tissues...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27910042/direct-cardiac-reprogramming-as-a-novel-therapeutic-strategy-for-treatment-of-myocardial-infarction
#4
Hong Ma, Li Wang, Jiandong Liu, Li Qian
Direct reprogramming of fibroblasts into induced cardiomyocytes (iCMs) holds great promise as a novel therapy for the treatment of heart failure, a common and morbid disease that is usually caused by irreversible loss of functional cardiomyocytes (CMs). Recently, we and others showed that in a murine model of acute myocardial infarction, delivery of three transcription factors, Gata4, Mef2c, and Tbx5 converted endogenous cardiac fibroblasts into functional iCMs. These iCMs integrated electrically and mechanically with surrounding myocardium, resulting in a reduction in scar size and an improvement in heart function...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27909731/hypoxia-drives-the-transition-of-human-dermal-fibroblasts-to-a-myofibroblast-like-phenotype-via-the-tgf-%C3%AE-1-smad3-pathway
#5
Bin Zhao, Hao Guan, Jia-Qi Liu, Zhao Zheng, Qin Zhou, Jian Zhang, Lin-Lin Su, Da-Hai Hu
Keloids, partially considered as benign tumors, are characterized by the overgrowth of fibrosis beyond the boundaries of the wound and are regulated mainly by transforming growth factor (TGF)-β1, which induces the transition of fibroblasts to myofibroblasts. Hypoxia is an important driving force in the development of lung and liver fibrosis by activating hypoxia inducible factor-1α and stimulating epithelial‑mesenchymal transition. However, it is unknown whether and hypoxia can influence human dermal scarring...
December 1, 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27909609/emergency-difficult-airway-management-in-a-patient-with-severe-epidermolysis-bullosa
#6
Ahmet Selim Özkan, Gülay Erdoğan Kayhan, Sedat Akbaş, Osman Kaçmaz, Mahmut Durmuş
Epidermolysis bullosa (EB) is a rare disease characterised by vesiculobullous lesions with minimal trauma to the skin and mucous membranes. Bleeding, scar tissue, contractures, oedema and lesions that can spread throughout the body can cause a difficult airway and vascular access in patients with EB. Therefore, anaesthetic management in patients with EB is a major problem even for experienced anaesthesiologists. Herein, we report a case of difficult airway management in a patient diagnosed with severe EB who presented for emergency tracheostomy because of respiratory failure under general anaesthesia...
October 2016: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/27909478/cardiac-resynchronization-therapy-in-non-ischemic-cardiomyopathy
#7
REVIEW
Miriam Shanks Md PhD, Victoria Delgado Md PhD, Jeroen J Bax Md PhD
Cardiac resynchronization therapy (CRT) is an established therapy for heart failure patients who remain symptomatic despite optimal medical therapy, have reduced left ventricular ejection fraction (<35%) and wide QRS duration (>120 ms), preferably with left bundle branch block morphology. The response to CRT depends on the cardiac substrate: presence of correctable left ventricular mechanical dyssynchrony, presence of myocardial fibrosis (scar) and position of the left ventricular pacing lead. Patients with non-ischemic cardiomyopathy have shown higher response rates to CRT compared with patients with ischemic cardiomyopathy...
February 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27909193/osteotomy-models-the-current-status-on-pain-scoring-and-management-in-small-rodents
#8
Annemarie Lang, Anja Schulz, Agnes Ellinghaus, Katharina Schmidt-Bleek
Fracture healing is a complex regeneration process which produces new bone tissue without scar formation. However, fracture healing disorders occur in approximately 10% of human patients and cause severe pain and reduced quality of life. Recently, the development of more standardized, sophisticated and commercially available osteosynthesis techniques reflecting clinical approaches has increased the use of small rodents such as rats and mice in bone healing research dramatically. Nevertheless, there is no standard for pain assessment, especially in these species, and consequently limited information regarding the welfare aspects of osteotomy models...
December 2016: Laboratory Animals
https://www.readbyqxmd.com/read/27908351/pim1-kinase-overexpression-enhances-ckit-cardiac-stem-cell-cardiac-repair-following-myocardial-infarction-in-swine
#9
Shathiyah Kulandavelu, Vasileios Karantalis, Julia Fritsch, Konstantinos E Hatzistergos, Viky Y Loescher, Frederic McCall, Bo Wang, Luiza Bagno, Samuel Golpanian, Ariel Wolf, Justin Grenet, Adam Williams, Aaron Kupin, Aaron Rosenfeld, Sadia Mohsin, Mark A Sussman, Azorides Morales, Wayne Balkan, Joshua M Hare
BACKGROUND: Pim1 kinase plays an important role in cell division, survival, and commitment of precursor cells towards a myocardial lineage, and overexpression of Pim1 in ckit(+) cardiac stem cells (CSCs) enhances their cardioreparative properties. OBJECTIVES: The authors sought to validate the effect of Pim1-modified CSCs in a translationally relevant large animal preclinical model of myocardial infarction (MI). METHODS: Human cardiac stem cells (hCSCs, n = 10), hckit(+) CSCs overexpressing Pim1 (Pim1(+); n = 9), or placebo (n = 10) were delivered by intramyocardial injection to immunosuppressed Yorkshire swine (n = 29) 2 weeks after MI...
December 6, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27907057/the-effects-of-irreversible-electroporation-on-the-colon-in-a-porcine-model
#10
Xiaomei Luo, Xianjun Liang, Jiannan Li, Jian Shi, Wenlong Zhang, Wei Chai, Jiuping Wu, Shuai Guo, Gang Fang, Xulong Zhou, Jianhua Zhang, Kecheng Xu, Jianying Zeng, Lizhi Niu
BACKGROUND AND AIM: Irreversible electroporation (IRE) is a method of targeted cell ablation which has been suggested as a potential cancer therapy as it leaves structures such as blood vessels and the extracellular matrix intact, thereby allowing the rapid recovery of healthy tissue. Here, we investigated the effects of IRE on the colon in vivo in a porcine model. METHODS: IRE ablation was performed on the colon walls of 12 female Tibet mini-pigs, creating a total of 24 lesions...
2016: PloS One
https://www.readbyqxmd.com/read/27906922/the-effectiveness-of-hyperbaric-oxygen-therapy-hbot-in-radiation-induced-haemorrhagic-cystitis
#11
Vincent Chong, Michael Rice
INTRODUCTION: Radiation cystitis is one of the possible complications from pelvic radiotherapy. Hyperbaric oxygen (HBOT) improves tissue oxygenation and healing of scarred tissue. AIMS: To assess the efficacy of hyperbaric oxygen therapy (HBOT) in the management of radiation-induced haemorrhagic cystitis in patients with urological cancers. METHODS: This is a retrospective review on all patients with macroscopic haematuria secondary to radiation induced haemorrhagic cystitis who were treated with hyperbaric oxygen therapy (HBOT) between 2009 and 2013...
December 2, 2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/27906521/modeling-the-human-scarred-heart-in-vitro-toward-new-tissue-engineered-models
#12
Janine C Deddens, Amir Hossein Sadeghi, Jesper Hjortnaes, Linda W van Laake, Marc Buijsrogge, Pieter A Doevendans, Ali Khademhosseini, Joost P G Sluijter
Cardiac remodeling is critical for effective tissue healing, however, excessive production and deposition of extracellular matrix components contribute to scarring and failing of the heart. Despite the fact that novel therapies have emerged, there are still no lifelong solutions for this problem. An urgent need exists to improve the understanding of adverse cardiac remodeling in order to develop new therapeutic interventions that will prevent, reverse, or regenerate the fibrotic changes in the failing heart...
December 1, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27906436/iliac-crest-bone-graft-a-23-years-hystory-of-infection-at-donor-site-in-vertebral-arthrodesis-and-a-review-of-current-bone-substitutes
#13
L Babbi, G Barbanti-Brodano, A Gasbarrini, S Boriani
OBJECTIVE: This is an exemplary case report underlining a relevant morbidity which could be associated to the use of autologous iliac crest bone graft (ICBG) for spine fusion. CASE REPORT: Starting from 1990, a 25-years-old woman underwent two subsequent surgical treatments for non-Hodgkin lymphoma vertebral localizations. In the second surgery, arthrodesis was obtained with autograft through right posterior iliac crest osteotomy. During the chemotherapy treatment following the surgery, the patient suffered from infection at posterior iliac crest scar, the site of previous graft, caused by methicillin-resistant Staphylococcus aureus...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27904832/frontal-fibrosing-alopecia-treatment-options
#14
Raymond Fertig, Antonella Tosti
Frontal fibrosing alopecia (FFA) is a rare dermatologic disease that causes scarring and hair loss and is increasing in prevalence worldwide. FFA patients typically present with hair loss in the frontal scalp region and eyebrows which may be associated with sensations of itching or burning. FFA is a clinically distinct variant of lichen planopilaris (LPP) that affects predominantly postmenopausal women, although men and premenopausal women may also be affected. Early diagnosis and prompt treatment are necessary to prevent definitive scarring and permanent hair loss...
November 2016: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/27904666/ad-hgf-improves-the-cardiac-remodeling-of-rat-following-myocardial-infarction-by-upregulating-autophagy-and-necroptosis-and-inhibiting-apoptosis
#15
Jiabao Liu, Peng Wu, Yunle Wang, Yingqiang Du, Nan A, Shuiyuan Liu, Yiming Zhang, Ningtian Zhou, Zhihui Xu, Zhijian Yang
Cell death in MI is the most critical determinant of subsequent left ventricular remodeling and heart failure. Besides apoptosis, autophagy and necroptosis have been recently found to be another two regulated cell death styles. HGF has been reported to have a protective role in MI, but its impact on the three death styles remains unclear. Thus, our study was performed to investigate the distribution of autophagy, apoptosis and necroptosis in cardiac tissues after MI and explore the role and mechanism of Ad-HGF on cardiac remodeling by regulating the three death styles...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27904501/human-amniotic-epithelial-cells-combined-with-silk-fibroin-scaffold-in-the-repair-of-spinal-cord-injury
#16
Ting-Gang Wang, Jie Xu, Ai-Hua Zhu, Hua Lu, Zong-Ning Miao, Peng Zhao, Guo-Zhen Hui, Wei-Jiang Wu
Treatment and functional reconstruction after central nervous system injury is a major medical and social challenge. An increasing number of researchers are attempting to use neural stem cells combined with artificial scaffold materials, such as fibroin, for nerve repair. However, such approaches are challenged by ethical and practical issues. Amniotic tissue, a clinical waste product, is abundant, and amniotic epithelial cells are pluripotent, have low immunogenicity, and are not the subject of ethical debate...
October 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27904409/morphological-characterization-and-chemical-composition%C3%A2-of-fruits-of-the-traditional-croatian-chestnut-variety%C3%A2-lovran-marron
#17
Igor Poljak, Nada Vahčić, Milica Gačić, Marilena Idžojtić
'Lovran Marron' is the only known traditional Croatian variety of the sweet chestnut. The objective of this study is to specify qualitative and quantitative morphological characteristics and to analyze the chemical composition of the 'Lovran Marron' fruits as well as to compare them to Marušnjak fruits (trees from the 'Lovran Marron' seed) and fruits from the local natural sweet chestnut population. Seven morphological characteristics were measured: fruit mass, height, width and thickness, scar length and width, and the length of the longest intrusion of the seed coat into the kernel...
June 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/27904309/robot-assisted-abdominal-cerclage-during-pregnancy
#18
Burak Zeybek, Amanda Hill, Gulden Menderes, Mostafa A Borahay, Masoud Azodi, Gokhan Sami Kilic
BACKGROUND AND OBJECTIVES: Cervical insufficiency is a difficult condition to diagnose and can lead to preterm birth, miscarriage, or perinatal infant morbidity and mortality. We conducted this retrospective case study and literature review to evaluate the safety and efficacy of robot-assisted abdominal cerclage during pregnancy. METHODS: We conducted a case series and a systematic review that included patients who underwent robot-assisted abdominal cerclage during pregnancy from January 2010 through March 2016...
October 2016: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/27904206/reticulate-pigmentation-associated-with-scarring-alopecia-in-an-elderly-woman-an-unusual-manifestation-of-lichen-planus-pigmentosus
#19
Vinod Kumar Sharma, Neetu Bhari, Sweta Subhadarshani, Neha Taneja, Rakesh Kumar Deepak
A 70-year-old woman presented with generalized reticulate pigmentation, scarring alopecia, and few discrete, violaceous plaques over the trunk and forearm. Dermoscopic evaluation of the reticulate plaque showed reticulate hyperpigmentation with multiple telangiectasias, and skin biopsy showed lichenoid interface dermatitis with marked pigment incontinence. Thus, a final diagnosis of poikiloderma due to lichen planus pigmentosus was considered.
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27904181/comparative-evaluation-of-topical-10-potassium-hydroxide-and-30-trichloroacetic-acid-in-the-treatment-of-plane-warts
#20
Sandhaya Jayaprasad, Radhakrishnan Subramaniyan, Shalini Devgan
BACKGROUND: Warts are benign proliferations of skin and mucosa caused by the human papillomavirus (HPV). Plane warts are caused by HPV types 3, 10, 28, and 41, occurring mostly in children and young adults. Among the treatment modalities, topical application of trichloroacetic acid (TCA) is age old. Potassium hydroxide (KOH) has a keratolytic effect on virus-infected cells. It is less irritating, less painful, less scar forming, and can be safely used in children too. Hence, it could be a better topical agent in the treatment of plane warts...
November 2016: Indian Journal of Dermatology
keyword
keyword
8951
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"