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Nicholas Brandmeir, Elena Nehrbass, James McInerney
INTRODUCTION:  Deep brain stimulator (DBS) infections are a persistent problem for patients undergoing this procedure. They may require further surgery, treatment with antibiotics, or even removal of the device. To date, no consensus exists on the best practices to avoid DBS infections or what factors predispose patients to an eventual infection. The goal of this study was to examine several patient factors for association with DBS infection. METHODS:  A single-center, single-surgeon quality improvement database was queried...
September 20, 2016: Curēus
Michael Tran, Vivienne Lea, Karen Briscoe
No abstract text is available yet for this article.
February 2016: Pathology
Aditya K Gupta, Jessie Carviel, William Abramovits
Alopecia areata (AA) is non-scarring hair loss resulting from an autoimmune disorder. Severity varies from patchy hair loss that often spontaneously resolves to severe and chronic cases that can progress to total loss of scalp and body hair. Many treatments are available; however, the efficacy of these treatments has not been confirmed, especially in severe cases, and relapse rates are high. First-line treatment often includes corticosteroids such as intralesional or topical steroids for mild cases and systemic steroids or topical immunotherapy with diphenylcyclopropenone or squaric acid dibutylester in severe cases...
October 22, 2016: American Journal of Clinical Dermatology
S E Choon, C F Ngim, S Premaa, K W Tey, M N Nalini
BACKGROUND: Limited information exists regarding paediatric psoriasis and its association with body mass index (bMI) in Asia. OBJECTIVES: to determine the clinico-epidemiological profile and to compare the bMI of children with and without psoriasis. METHODS: A case-control study of 92 children with psoriasis versus 59 with atopic eczema and 56 with non-inflammatory skin conditions. RESULTS: Psoriasis was more common in Malay and Indian children when compared to Chinese with odds ratios (Or) of 4...
August 2016: Medical Journal of Malaysia
Tomoyuki Hioki, Hiroyuki Takama, Sumiko Makita, Masashi Akiyama
Aplasia cutis congenita (ACC) is a rare congenital disorder characterized by the absence of skin at birth, typically involving the midline of the scalp. This is the first case report to highlight the usefulness of precise ultrasonography for diagnosing mild ACC. A 1-month-old boy was referred to our hospital for assessment of a bald patch found at birth. He was born to nonconsanguineous parents in spontaneous vaginal delivery with a vacuum extractor because of fetal distress and anomaly of rotation at 40 weeks of gestation...
October 21, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Ramesh Kumar, Frederic W B Deleyiannis, Corbett Wilkinson, Brent R O'Neill
OBJECTIVE The authors' goals in this study were to describe a series of dog attacks on children that required neurosurgical consultation and to better understand the pattern of injuries inflicted, the circumstances that place children at risk for attack, and the dog breeds involved. In addition, the authors review the surgical and medical management of these patients. METHODS The authors performed a retrospective review of all children requiring neurosurgical consultation for dog bite at a regional Level 1 pediatric trauma center over a 15-year period...
October 21, 2016: Journal of Neurosurgery. Pediatrics
S L Lu
Experienced over twenty years of theoretical accumulation and ten years of clinical exploration, wound repair speciality in our country is in the phase of enhancing comprehensive ability. Our wound healing experts team has successfully carried out treatment of suspected bacterial weapon related chronic wounds, which lasted up to more than 70 years, through multilateral cooperation. We summarized the surgical program of wound fibrous tissue removal and scalp as donor sites for long-term non-healing wounds in the elderly...
October 20, 2016: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
Mona Malakouti, Gabrielle E Brown, Argentina Leon, Eva Wang, April N Naegeli, Emily Edson-Heredia, Ethan Levin, John Y M Koo
INTRODUCTION: Patient-reported outcome measures are increasingly utilized in dermatology to assess the impact of skin disease on quality of life. Despite recognition of the influence of skin disease on intimate relationships, an instrument to assess intimacy has not been developed. The objective of this study was to create the Dermatologic Intimacy Scale (DIS) and administer the prototype to a patient population. METHODS: A group of healthcare providers at the University of California San Francisco created the DIS prototype...
October 21, 2016: Journal of Dermatological Treatment
Rohit Marawar, Hsiang J Yeh, Chris Carnabatu, John M Stern
INTRODUCTION: The EEG rhythms demonstrate changes in frequency and power with spontaneous changes in behavioral state that do not have well understood metabolic correlates within the brain. To investigate this question and compare the temporal lobe theta and delta rhythms, resting-state functional MRI (fMRI) was obtained with simultaneous EEG. METHODS: Simultaneous EEG-fMRI was recorded from 14 healthy, sleep-deprived subjects in awake and drowsy states. Scalp electrodes corresponding to bilateral temporal lobes were used to calculate delta and theta band power...
October 18, 2016: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
Mathangi Chandramouli, Digvijay Sarma, Kapil Tejaswy, Gabriel Rodrigues
Syringocystadenoma papilliferum (SCAP) is a rare, benign tumour with varied presentations that arises from the apocrine glands and at times can lead to a diagnostic dilemma. A 53-year-old male presented with a 40-year history of a scalp nodule and a recent 2-year change in its character, and a sanguinopurulent discharge. Examination revealed a 4 cm × 2 cm firm nodule upon left side of the scalp vertex, actively discharging pus and blood. No regional lymph nodes were noticeably palpable. Incision biopsy performed elsewhere showed evidence of a squamous cell carcinoma-in-situ...
July 2016: Journal of Cutaneous and Aesthetic Surgery
Dalia El Sakka, Mohamed Abdel Wahed Gaber, Asmaa Gaber Abdou, Moshira Abdel Wahed, Ahmed Abdel-Wahab Saleh, Walla Shehata
BACKGROUND: Alopecia is one of the most important hair follicle (HF) disorders, which is divided into scarring (cicatricial) and nonscarring (noncicatricial) types. OBJECTIVE: The aim of this study is to investigate the expression of stem cell (SC) markers such as cytokeratin (CK) 17 and CK19 in scarring and nonscarring alopecia. MATERIALS AND METHODS: Thirty patients with scalp alopecia (15 with scarring alopecia and 15 without) together with ten healthy volunteers were included in this study...
July 2016: Journal of Cutaneous and Aesthetic Surgery
Cornelia Wiegand, Peter Mugisha, Grace K Mulyowa, Peter Elsner, Uta-Christina Hipler, Yvonne Gräser, Silke Uhrlaß, Pietro Nenoff
Tinea capitis is a dermatophyte infection common among prepubertal children in sub-Saharan Africa and mainly caused by Trichophyton and Microsporum species. Accurate identification is challenging as conventional methods like culture and microscopy are slow and mostly based on morphological characteristics, which make them less sensitive and specific. Modern molecular methods, like polymerase chain reaction (PCR) assays, are gaining acceptance and are quick as well as accurate. The aim of this study was to investigate the clinical patterns of tinea capitis and to accurately identify the most common causative dermatophytes affecting the scalps of children aged 1 to 16 years attending the Skin Clinic at Mbarara University of Science and Technology (MUST), Mbarara, Uganda, East Africa, using both conventional mycological methods and PCR-ELISA for detection of dermatophyte DNA...
October 19, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Kristian Reich, Craig Leonardi, Mark Lebwohl, Francisco Kerdel, Yukari Okubo, Ricardo Romiti, Orin Goldblum, Ellen B Dennehy, Lisa Kerr, Howard Sofen
BACKGROUND: Scalp is a frequently affected and difficult-to-treat area in psoriasis patients. OBJECTIVES: We assessed the efficacy of ixekizumab in the treatment of patients with scalp psoriasis over 60 weeks using the Psoriasis Scalp Severity Index (PSSI). METHODS: In three Phase 3, multicenter, double-blind, placebo-controlled trials, patients with moderate-to-severe psoriasis in UNCOVER-1 (N = 1296), UNCOVER-2 (N = 1224), and UNCOVER-3 (N = 1346) were randomized to subcutaneous 80 mg ixekizumab every 2 weeks (Q2W) or every 4 weeks (Q4W) after a 160 mg starting dose, or placebo through Week 12...
October 19, 2016: Journal of Dermatological Treatment
Francesco Ricci, Andrea Paradisi, Giorgio Annessi, Mauro Paradisi, Damiano Abeni
BACKGROUND: The solitary form of Spitz nevus is a common clinical entity in children, typically occurring on the face and extremities. However, less frequent variants of Spitz nevi, such as agminated forms and eruptive disseminated Spitz nevi (EDSN), have been described. The agminated form is characterised by localised clusters or segmental distribution of Spitz nevi on the face, back, or extremities. First described as "eruptive juvenile melanomata", EDSN is the rarest clinical variant, consisting of a widespread eruption of Spitz nevi, most frequently involving the trunk, buttocks, and proximal limbs, and usually occurs in the second to third decade of life...
October 19, 2016: European Journal of Dermatology: EJD
Victoria A McCredie, Simone Piva, Marlene Santos, Wei Xiong, Airton Leonardo de Oliveira Manoel, Andrea Rigamonti, Gregory M T Hare, Martin G Chapman, Andrew J Baker
BACKGROUND: There are a range of opinions on the benefits and thresholds for the transfusion of red blood cells in critically ill patients with traumatic brain injury (TBI) and an urgent need to understand the neurophysiologic effects. The aim of this study was to examine the influence of red blood cell transfusions on cerebral tissue oxygenation (SctO2) in critically ill TBI patients. METHODS: This prospective observational study enrolled consecutive TBI patients with anemia requiring transfusion...
October 18, 2016: Neurocritical Care
Shahnawaz Baloch, Tasneem Gul Kazi, Hassan Imran Afridi, Jameel Ahmed Baig, Farah Naz Talpur, Muhammad Balal Arain
There is some evidence that natural levels of lithium (Li) in drinking water may have a protective effect on neurological health. In present study, we evaluate the Li levels in drinking water of different origin and bottled mineral water. To evaluate the association between lithium levels in drinking water with human health, the scalp hair samples of male subjects (25-45 years) consumed drinking water obtained from ground water (GW), municipal treated water (MTW) and bottled mineral water (BMW) from rural and urban areas of Sindh, Pakistan were selected...
October 18, 2016: Environmental Geochemistry and Health
Kristyna Gleghorn, Brandon Goodwin, Ramon Sanchez
Chordoma is a rare primary bone malignancy of notochord origin, representing 1-4% of malignant bone tumors. Typically, chordomas follow a slow progressive course with aggressive local extension, multiple recurrences, and metastases. Of particular interest to this case, cutaneous metastasis is exceedingly rare. Diagnosis of this entity can be a challenge due to the rarity of chordoma, as well as the infrequent presentation of distant cutaneous metastasis and non-specific clinical skin findings. We report a case of a 61-year-old male with a history of sacral chordoma treated by wide local excision 8 years prior to presentation developed a nodule on his scalp for 6 weeks...
October 14, 2016: American Journal of Dermatopathology
Anna Serafini, Naoum Issa, Sandra Rose, Shasha Wu, Peter Warnke, James X Tao
Electrophysiological studies have suggested that temporal intermittent rhythmic delta activity (TIRDA) has a localizing value similar to interictal spikes in patients with temporal lobe epilepsy, and is associated with a favorable outcome after temporal lobectomyHowever, it remains controversial whether TIRDA is an EEG marker for mesial or lateral temporal epileptogenesis. We simultaneously recorded scalp EEG and stereoencephalography (SEEG) in a patient with mesial temporal lobe epilepsy (mTLE) during epilepsy pre-surgical evaluation...
June 13, 2016: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
Renée M Symonds, Wei Wei Lee, Adam Kohn, Odelia Schwartz, Sarah Witkowski, Elyse S Sussman
The auditory mismatch negativity (MMN) component of event-related potentials (ERPs) has served as a neural index of auditory change detection. MMN is elicited by presentation of infrequent (deviant) sounds randomly interspersed among frequent (standard) sounds. Deviants elicit a larger negative deflection in the ERP waveform compared to the standard. There is considerable debate as to whether the neural mechanism of this change detection response is due to release from neural adaptation (neural adaptation hypothesis) or from a prediction error signal (predictive coding hypothesis)...
October 17, 2016: Brain Topography
Rebecca Re, Edoardo Martinenghi, Alberto Dalla Mora, Davide Contini, Antonio Pifferi, Alessandro Torricelli
We report the development of a compact probe for time-domain (TD) functional near-infrared spectroscopy (fNIRS) based on a fast silicon photomultiplier (SiPM) that can be put directly in contact with the sample without the need of optical fibers for light collection. We directly integrated an avalanche signal amplification stage close to the SiPM, thus reducing the size of the detection channel and optimizing the signal immunity to electromagnetic interferences. The whole detection electronics was placed in a plastic screw holder compatible with the electroencephalography standard cap for measurement on brain or with custom probe holders...
October 2016: Neurophotonics
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