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https://www.readbyqxmd.com/read/29346793/epicardial-fat-thickness-in-non-obese-neurologically-impaired-children-association-with-unfavorable-cardiometabolic-risk-profile
#1
Valeria Calcaterra, Hellas Cena, Pietro Mariano Casali, Gianluca Iacobellis, Riccardo Albertini, Mara De Amici, Annalisa de Silvestri, Calogero Comparato, Gloria Pelizzo
BACKGROUND: Cardiovascular risk is reported in disabled children and epicardial fat (EF) is considered an independent predictor of cardiovascular disease (CVD). No data on the EF thickness (EFT) evaluation in disabled children have been published. OBJECTIVE: We investigated EFT in neurologically impaired (NI) children; its relationship with their metabolic profile was also considered. METHODS: Clinical data, body composition estimation, biochemical profile, and ultrasound-measured EFT were performed in 32 disabled patients (12...
January 18, 2018: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29345123/the-effects-of-lifestyle-changes-on-serum-lipid-levels-in-children-in-a-real-life-setting
#2
Angeline D Opina, Constance Cephus, Yunfei Wang, Samuel Younan, Douglas Moodie
OBJECTIVE: Studies have shown improvement in lipid levels after institution of lifestyle changes in children enrolled in closely monitored programs. There programs are difficult to mimic in real world clinics. We aim to determine if diet and exercise result in improvement in lipid levels in patients seen in a designated lipid clinic in a real life setting. DESIGN: Retrospective review of patients followed for dyslipidemia at the Texas Children's Hospital Lipid Clinic from May 1, 2012 to May 1, 2015...
January 18, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29344739/what-we-have-learned-from-the-recent-meta-analyses-on-diagnostic-methods-for-atherosclerotic-plaque-regression
#3
REVIEW
Giuseppe Biondi-Zoccai, Simona Mastrangeli, Enrico Romagnoli, Mariangela Peruzzi, Giacomo Frati, Leonardo Roever, Arturo Giordano
PURPOSE OF REVIEW: Atherosclerosis has major morbidity and mortality implications globally. While it has often been considered an irreversible degenerative process, recent evidence provides compelling proof that atherosclerosis can be reversed. Plaque regression is however difficult to appraise and quantify, with competing diagnostic methods available. Given the potential of evidence synthesis to provide clinical guidance, we aimed to review recent meta-analyses on diagnostic methods for atherosclerotic plaque regression...
January 17, 2018: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29341046/reduced-growth-hormone-secretion-is-associated-with-nonalcoholic-fatty-liver-disease-in-obese-children
#4
Shuang Liang, Zhen Yu, Xiaobo Song, Yu Wang, Meng Li, Jiang Xue
The purpose of the study was to evaluate the relationship between arginine-levodopa-induced growth hormone (GH) secretion and nonalcoholic fatty liver disease (NAFLD) in obese children. This study includes a total of 84 obese and 43 normal weight children. The obese subjects are divided into two groups based on the presence or absence of NAFLD. Clinical examination, anthropometric and laboratory examinations, and liver ultrasonography are assessed for all participants. The obese group had significantly lower peak stimulated GH (p<0...
January 16, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29340961/metabolic-syndrome-and-its-components-among-korean-submariners-a-retrospective-cross-sectional-study
#5
Jihun Kang, Yun-Mi Song
PURPOSE: Metabolic syndrome (MetS) is a cluster of inter-related risk factors for cardiovascular disease and diabetes. Although submariners tend to be exposed to unhealthy environmental factors, such as a confined work environment, physical inactivity, and circadian disruption, little is known regarding whether the risks of MetS and its components are associated with submarine service. The present study aimed to evaluate the risks of MetS and its components among submariners. METHODS: A total of 5090 subjects (513 submariners and 4577 non-submariners) were included in the present study...
January 16, 2018: Endocrine
https://www.readbyqxmd.com/read/29340525/time-collection-and-storage-conditions-of-lipid-profile
#6
C N França, C C Mendes, C E S Ferreira
The stability of samples is crucial for getting reliable concentrations of many analytes, including lipid profile. Thus, the goal of this study was to analyze lipid profile under different storage and temperature conditions. This was a prospective study with 809 patients of both genders. Total cholesterol, triglycerides, high-density lipoprotein cholesterol, low density lipoprotein cholesterol and non-high-density lipoprotein were measured within 1 h from collection at room temperature, after 2-3 h of refrigeration (8°C) and after 4-5 h at room temperature...
January 11, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29340036/the-association-between-elevated-fasting-plasma-glucose-levels-and-carotid-intima-media-thickness-in-non-diabetic-adults-a-population-based-cross-sectional-study
#7
Yalin Guan, Changshen Yu, Min Shi, Jingxian Ni, Yanan Wu, Hongfei Gu, Lingling Bai, Jie Liu, Jun Tu, Jinghua Wang, Xianjia Ning
We assessed the association between the mean carotid intima-media thickness (CIMT) and fasting plasma glucose (FPG) levels in a low-income population in rural China. Adults aged ≥45 years without a history of diabetes, stroke, or cardiovascular disease were recruited. All participants were categorized into four groups according to FPG level. A total of 3509 participants were analyzed in this study. In the univariate analysis, sex, age, education level, hypertension, central obesity, current smoking, alcohol consumption, and higher levels of FPG, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were associated with mean CIMT and frequency of increased CIMT...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29337071/lower-protein-and-higher-carbohydrate-intake-is-related-with-altering-metabolic-syndrome-components-in-elderly-women-a-cross-sectional-study
#8
Hellen C G Nabuco, Crisieli M Tomeleri, Paulo Junior Sugihara, Rodrigo Dos Reis Fernandes, Edilaine F Cavalcante, Melissa Antunes, Roberto Carlos Burini, Danielle Venturini, Décio S Barbosa, Analiza Mônica Silva, Edilson S Cyrino
BACKGROUND: Metabolic Syndrome (MetS) is an energy-disturbance disease associated with insulin resistance. Hence, the intake of energy-rich macronutrients might affect some MetS components. The aim of this study was to explore the association of ingested macronutrients with MetS components in older women. METHODS: A cross sectional study was conducted in 245 older women (≥60 years). Whole-body dual-energy X-ray absorptiometry was used to assess total body fat, percentage body fat (absolute and relative), and skeletal muscle mass...
January 11, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29336935/update-on-the-laboratory-investigation-of-dyslipidemias
#9
REVIEW
I Ramasamy
The role of the clinical laboratory is evolving to provide more information to clinicians to assess cardiovascular disease (CVD) risk and target therapy more effectively. Current routine methods to measure LDL-cholesterol (LDL-C), the Friedewald calculation, ultracentrifugation, electrophoresis and homogeneous direct methods have established limitations. Studies suggest that LDL and HDL size or particle concentration are alternative methods to predict future CVD risk. At this time there is no consensus role for lipoprotein particle or subclasses in CVD risk assessment...
January 11, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29336612/relationship-among-adiponectin-insulin-resistance-and-atherosclerosis-in-non-diabetic-hypertensive-patients-and-healthy-adults
#10
Huijuan Kou, Jie Deng, Dengfeng Gao, Anqi Song, Zhenhua Han, Jin Wei, Xin Jin, Rui Ma, Qiangsun Zheng
Adiponectin, which is secreted specifically by adipose tissue, has been shown to have anti-atherogenic and anti-inflammatory effects and to improve insulin resistance (IR). The aim of this study was to determine the correlations among adiponectin, IR and atherosclerosis in non-diabetic hypertensive patients and healthy volunteers. In this case control study, we collected complete demographic data from and measured several laboratory parameters in all enrolled subjects. The homeostasis model of assessment for insulin resistance (HOMA-IR) was calculated as an insulin sensitivity index...
January 16, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29335857/effect-of-soothing-gan-liver-and-invigorating-pi-spleen-recipes-on-tlr4-p38-mapk-pathway-in-kupffer-cells-of-non-alcoholic-steatohepatitis-rats
#11
Xiang-Wen Gong, Yong-Jian Xu, Qin-He Yang, Yin-Ji Liang, Yu-Pei Zhang, Guan-Long Wang, Yuan-Yuan Li
OBJECTIVE: To investigate the mechanism of inflammatory-mediated toll-like receptor 4 (TLR4)-p38 mitogen-activated protein kinase (p38 MAPK) pathway in Kupffer cells (KCs) of non-alcoholic steatohepatitis (NASH) rats and the intervention effect of soothing Gan (Liver) and invigorating Pi (Spleen) recipes on this pathway. METHODS: After 1 week of acclimatization, 120 Sprague-Dawley male rats were randomly divided into 8 groups using a random number table (n=15 per group): normal group, model group, low-dose Chaihu Shugan Powder (, CHSG) group (3...
January 9, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29334984/new-insights-into-angplt3-in-controlling-lipoprotein-metabolism-and-risk-of-cardiovascular-diseases
#12
REVIEW
Xin Su, Dao-Quan Peng
Dyslipidemia, characterized by elevation of plasma low density lipoprotein cholesterol (LDL-C), triglyceride (TG) and reduction of plasma high density lipoprotein cholesterol (HDL-C), has been verified as a causal risk factor for cardiovascular diseases (CVD), leading to a high mortality rate in general population. It is important to understand the molecular metabolism underlying dyslipidemia in order to reduce the risk and to develop effective therapeutic approaches against CVD. ANGPTL3 (human) or Angptl3 (mouse), one member of the angiopoietin-like protein (ANGPTL) family, has been identified as an important regulator of lipid metabolism by inhibiting LPL and EL activity...
January 15, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29334743/-adiponectin-in-patients-with-metabolic-syndrome-and-diseases-of-the-liver-bile-ducts-and-pancreas
#13
Adam Vašura, Martin Blaho, Petr Dítě, Tomáš Kupka, Pavel Svoboda, Arnošt Martínek
Epidemiological data show that the metabolic syndrome can be diagnosed in up to 30 % of the population. Regarding 5 components of the metabolic syndrome, three of them, in case of positivity (visceral obesity, arterial hypertension, hypertriglyceridemia, changes of HDL-cholesterol levels and type 2 diabetes mellitus), are pathogenic factors which are the most frequently related to cardiovascular diseases, but currently they are also the focus of interest for gastroenterologists. The relationship between non-alcoholic hepatic steatosis, including non-alcoholic steatohepatitis, has been described...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29331538/differential-lipid-metabolism-outcomes-associated-with-adrb2-gene-polymorphisms-in-response-to-two-dietary-interventions-in-overweight-obese-subjects
#14
O Ramos-Lopez, J I Riezu-Boj, F I Milagro, L Goni, M Cuervo, J A Martinez
BACKGROUND AND AIMS: A precise nutrigenetic management of hypercholesterolemia involves the understanding of the interactions between the individual's genotype and dietary intake. The aim of this study was to analyze the response to two dietary energy-restricted interventions on cholesterol changes in carriers of two ADRB2 polymorphisms. METHODS AND RESULTS: A 4-month nutritional intervention was conducted involving two different hypo-energetic diets based on low-fat (LF) and moderately high-protein (MHP) dietary patterns...
December 5, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29330836/pathogenesis-of-non-alcoholic-fatty-liver-disease-mediated-by-yap
#15
Ping Chen, Qihui Luo, Chao Huang, Qi Gao, Like Li, Jingfei Chen, Bing Chen, Wentao Liu, Wen Zeng, Zhengli Chen
OBJECTIVE: This study aimed to investigate the mechanism of the interaction between Yes-associated protein (YAP) and transforming growth factor-β (TGF-β)/Smad signaling pathways in the development of non-alcoholic fatty liver disease (NAFLD). METHODS: Serum samples of monkeys with biopsy-proven NAFLD and healthy normal monkeys were used to measure fasting plasma glucose (FPG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride (TG) and albumin (ALB) with the BECKMAN CX5 PRO...
January 12, 2018: Hepatology International
https://www.readbyqxmd.com/read/29326417/factors-causing-disagreement-between-measured-and-calculated-low-density-lipoprotein-cholesterol-ldl-c-in-clinical-laboratory-services
#16
Veeravan Lekskulchai
BACKGROUND Since measured low density lipoprotein-cholesterol (LDL-C) has been available in clinical laboratories, there have been concern about the disagreement between measured and calculated LDL-C and the factors causing their disagreement. MATERIAL AND METHODS Serum lipid concentrations were collected from 1,339 medical records of patients admitted to hospital between 2013 and 2015. They were grouped by their total cholesterol (TC), triglycerides (TG), and high-density lipoprotein-cholesterol (HDL-C) concentrations and the agreement between measured and calculated LDL-C was statistically analyzed...
January 12, 2018: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/29324585/effects-of-metabolic-syndrome-on-arterial-function-in-different-age-groups-the-advanced-approach-to-arterial-stiffness-study
#17
Jirar Topouchian, Carlos Labat, Sylvie Gautier, Magnus Bäck, Apostolos Achimastos, Jacques Blacher, Marcin Cwynar, Alejandro de la Sierra, Denes Pall, Francesco Fantin, Katalin Farkas, Luis Garcia-Ortiz, Zoya Hakobyan, Piotr Jankowski, Ana Jelakovic, Zhanna Kobalava, Alexandra Konradi, Yulia Kotovskaya, Marina Kotsani, Irina Lazareva, Alexander Litvin, Viktor Milyagin, Iveta Mintale, Oscar Persson, Rafael Ramos, Anatoly Rogoza, Ligita Ryliskyte, Angelo Scuteri, Yuriy Sirenko, Georges Soulis, Nebojsa Tasic, Maryna Udovychenko, Saule Urazalina, Peter Wohlfahrt, Parounak Zelveian, Athanase Benetos, Roland Asmar
OBJECTIVE: The aim of the Advanced Approach to Arterial Stiffness study was to compare arterial stiffness measured simultaneously with two different methods in different age groups of middle-aged and older adults with or without metabolic syndrome (MetS). The specific effects of the different MetS components on arterial stiffness were also studied. METHODS: This prospective, multicentre, international study included 2224 patients aged 40 years and older, 1664 with and 560 without MetS...
January 10, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29324459/discordance-between-lipoprotein-particle-number-and-cholesterol-content-an-update
#18
Eric P Cantey, John T Wilkins
PURPOSE OF REVIEW: The cholesterol content within atherogenic apolipoprotein-B (apoB) containing lipid particles is the center of consensus guidelines and clinicians' focus whenever evaluating a patient's risk for atherosclerotic cardiovascular disease. The pathobiology of atherosclerosis requires the retention of lipoprotein particles within the vascular intima over time followed by maladaptive inflammation resulting in plaque formation and rupture in some. The cholesterol content is widely variable within each particle creating either cholesterol-deplete or cholesterol-enriched particles...
January 10, 2018: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/29321674/body-mass-index-waist-circumference-and-waist-to-height-ratio-for-prediction-of-multiple-metabolic-risk-factors-in-chinese-elderly-population
#19
Zhan Gu, Dong Li, Huayu He, Jianying Wang, Xiaojuan Hu, Peihua Zhang, Yanlong Hong, Baocheng Liu, Lei Zhang, Guang Ji
The purpose of this study was to compare the predictive ability of five obesity indices, including body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), waist-to-hip ratio (WHpR) and body adiposity index (BAI), to predict multiple non-adipose metabolic risk factors, including elevated blood pressure (BP), elevated fasting plasma glucose (FPG), elevated triglyceride (TG), reduced high-density lipoprotein cholesterol (HDL-C), elevated serum uric acid (SUA) and non-alcoholic fatty liver disease (NAFLD), in an elderly Chinese population...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29319245/cardiometabolic-risk-factors-in-acute-coronary-syndrome-with-special-reference-to-non-hdl-cholesterol
#20
Debjani S Goswami, Tanuja P Manohar
Introduction: Cardiovascular diseases are becoming the major cause of morbidity and mortality in most of the developing countries including India. Cardiometabolic risk factors play a vital role in causation of coronary artery disease. Present study was carried out to investigate the role of various risk factors in the occurrence of coronary artery disease (CAD) in population from Central India. Settings and Design: This was a hospital-based age and sex matched case-control study, carried out at Lata Mangeshkar Hospital, Nagpur...
October 2017: Journal of the Association of Physicians of India
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