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https://www.readbyqxmd.com/read/29771383/relationship-of-fibroblast-growth-factor-21-with-kidney-function-and-albuminuria-multi-ethnic-study-of-atherosclerosis
#1
Sahapab Anuwatmatee, Matthew A Allison, Michael G Shlipak, Robyn L McClelland, Holly Kramer, Shudi Tang, Liming Hou, Kerry-Anne Rye, Kwok Leung Ong
Background: Fibroblast growth factor 21 (FGF21) may play a role in the development of chronic kidney disease (CKD). We therefore investigated the relationship of plasma FGF21 levels with kidney function and albuminuria in the Multi-Ethnic Study of Atherosclerosis (MESA). Methods: The analysis included 5724 MESA participants ages 45-84 years between 2000 and 2002, free of clinically apparent cardiovascular disease (CVD). Participants were followed up in person at four additional clinic visits over 10 years...
May 15, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29751988/chronic-kidney-disease-in-persons-living-with-hiv-a-systematic-review
#2
Jungmin Park, Julie Ann Zuñiga
The purpose of our systematic review of research on chronic kidney disease (CKD) in persons living with HIV (PLWH) was to (a) compare and contrast diagnostic criteria for CKD, (b) identify risk factors of CKD in PLWH, and (c) elucidate the prevalence of CKD in PLWH. Keyword searches of PubMed and PsycInfo databases were followed by manual searches of references from 2000 through 2016; 21 studies met inclusion criteria. Sample sizes ranged from 8 to 15,140, with a mean age of 50 years, and represented diverse ethnicities/races and countries of origin...
April 19, 2018: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/29728316/cognitive-impairment-in-non-dialysis-dependent-ckd-and-the-transition-to-dialysis-findings-from-the-chronic-renal-insufficiency-cohort-cric-study
#3
Meera N Harhay, Dawei Xie, Xiaoming Zhang, Chi-Yuan Hsu, Eric Vittinghoff, Alan S Go, Stephen M Sozio, Jacob Blumenthal, Stephen Seliger, Jing Chen, Rajat Deo, Mirela Dobre, Sanjeev Akkina, Peter P Reese, James P Lash, Kristine Yaffe, Manjula Kurella Tamura
BACKGROUND: Advanced chronic kidney disease is associated with elevated risk for cognitive impairment. However, it is not known whether and how cognitive impairment is associated with planning and preparation for end-stage renal disease. STUDY DESIGN: Retrospective observational study. SETTING & PARTICIPANTS: 630 adults participating in the CRIC (Chronic Renal Insufficiency Cohort) Study who had cognitive assessments in late-stage CKD, defined as estimated glome-rular filtration rate ≤ 20mL/min/1...
May 2, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29668591/prevalence-and-correlates-of-chronic-kidney-disease-ckd-among-art-naive-hiv-patients-in-the-niger-delta-region-of-nigeria
#4
Udeme E Ekrikpo, Andre P Kengne, Effiong E Akpan, Emmanuel E Effa, Aminu K Bello, John U Ekott, Cindy George, Babatunde L Salako, Ikechi G Okpechi
Widespread use of antiretroviral therapy (ART) in human immunodeficiency virus (HIV) patients has led to improved longevity with the attendant increase in noncommunicable disease prevalence including chronic kidney disease (CKD). This study documents the prevalence of CKD in a large HIV population in Southern Nigeria.This is a single center, 15-year analysis in ART-naïve patients. CKD was defined as the occurrence of estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m on 2 consecutive occasions 3 to 12 months apart using the chronic kidney disease epidemiology collaboration (CKD-EPI) equation...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29525790/race-ethnicity-dietary-acid-load-and-risk-of-end-stage-renal-disease-among-us-adults-with-chronic-kidney-disease
#5
Deidra C Crews, Tanushree Banerjee, Donald E Wesson, Hal Morgenstern, Rajiv Saran, Nilka Ríos Burrows, Desmond E Williams, Neil R Powe
BACKGROUND: Dietary acid load (DAL) contributes to the risk of CKD and CKD progression. We sought to determine the relation of DAL to racial/ethnic differences in the risk of end-stage renal disease (ESRD) among persons with CKD. METHODS: Among 1,123 non-Hispanic black (NHB) and non-Hispanic white (NHW) National Health and Nutrition Examination Survey III participants with estimated glomerular filtration rate 15-59 mL/min/1.73 m2, DAL was estimated using the Remer and Manz net acid excretion (NAEes) formula and 24-h dietary recall...
2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29525779/non-st-segment-elevation-myocardial-infarction-among-patients-with-chronic-kidney-disease-a-propensity-score-matched-comparison-of-percutaneous-coronary-intervention-versus-conservative-management
#6
Subir Bhatia, Shilpkumar Arora, Sravya M Bhatia, Mohammed Al-Hijji, Yogesh N V Reddy, Parshva Patel, Charanjit S Rihal, Bernard J Gersh, Abhishek Deshmukh
BACKGROUND: Chronic kidney disease (CKD) remains an independent predictor of cardiovascular morbidity and mortality. CKD complicates referral for percutaneous coronary intervention (PCI) in non-ST-segment-elevation myocardial infarction (NSTEMI) patients because of the risk for acute kidney injury and the need for dialysis, with American College of Cardiology/American Heart Association guidelines underscoring the limited data on these patients. METHODS AND RESULTS: Using the National Inpatient Sample to analyze hospitalizations in the United States from 2004 to 2014, we sought to assess PCI utilization and in-hospital outcomes in NSTEMI admissions with CKD...
March 10, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29404927/fast-gfr-decline-and-progression-to-ckd-among-primary-care-patients-with-preserved-gfr
#7
Farrukh M Koraishy, Denise Hooks-Anderson, Joanne Salas, Michael Rauchman, Jeffrey F Scherrer
BACKGROUND: Fast glomerular filtration rate (GFR) decline is associated with adverse outcomes, but the associated risk factors among patients without chronic kidney disease (CKD) are not well defined. METHODS: From a primary care registry of 37,796, we identified 2219 (6%) adults with at least three estimated (e)GFR values and a baseline eGFR between 60 and 119 ml/min/1.73 m2 during an observation period of 8 years. We defined fast GFR decline as > 5 ml/min/1...
March 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29396621/progressive-kidney-disease-may-not-alter-the-association-of-hyponatremia-with-mortality
#8
Ladan Golestaneh, Joel Neugarten, Frederick Kaskel, Aileen P McGinn
BACKGROUND: Hyponatremia is a common electrolyte disorder and a prognostic marker for mortality. We hypothesize that in advanced chronic or acute kidney disease, hyponatremia is not independently associated with mortality because of the contribution of kidney failure to its pathophysiology. METHODS: Clinical Looking Glass, Montefiore's clinical database, was used to build a cohort of all patients hospitalized between January of 2009 and December of 2011. A chronic kidney disease (CKD) group and an acute kidney injury (AKI) group were defined based on GFR measurements during and before index hospitalization...
February 2, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29370229/risk-factors-for-death-stroke-and-bleeding-in-28-628-patients-from-the-garfield-af-registry-rationale-for-comprehensive-management-of-atrial-fibrillation
#9
Jean-Pierre Bassand, Gabriele Accetta, Wael Al Mahmeed, Ramon Corbalan, John Eikelboom, David A Fitzmaurice, Keith A A Fox, Haiyan Gao, Samuel Z Goldhaber, Shinya Goto, Sylvia Haas, Gloria Kayani, Karen Pieper, Alexander G G Turpie, Martin van Eickels, Freek W A Verheugt, Ajay K Kakkar
BACKGROUND: The factors influencing three major outcomes-death, stroke/systemic embolism (SE), and major bleeding-have not been investigated in a large international cohort of unselected patients with newly diagnosed atrial fibrillation (AF). METHODS AND RESULTS: In 28,628 patients prospectively enrolled in the GARFIELD-AF registry with 2-year follow-up, we aimed at analysing: (1) the variables influencing outcomes; (2) the extent of implementation of guideline-recommended therapies in comorbidities that strongly affect outcomes...
2018: PloS One
https://www.readbyqxmd.com/read/29319880/competing-risks-of-fracture-and-death-in-older-adults-with-chronic-kidney-disease
#10
Rasheeda K Hall, Richard Sloane, Carl Pieper, Courtney Van Houtven, Joanne LaFleur, Robert Adler, Cathleen Colón-Emeric
OBJECTIVES: To examine whether chronic kidney disease (CKD) at any stage is associated with fracture risk after adjusting for competing mortality and to determine whether age or race modify the relationship between CKD and fracture risk. DESIGN: Prospective cohort study. SETTING: Department of Veterans Affairs (VA) national healthcare system. PARTICIPANTS: Men receiving VA primary care aged 65 and older with no history of fracture or osteoporosis therapy (N = 712, 918)...
March 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29295853/is-blood-pressure-improving-in-children-with-chronic-kidney-disease-a-period-analysis
#11
Gina-Marie Barletta, Christopher Pierce, Mark Mitsnefes, Joshua Samuels, Bradley A Warady, Susan Furth, Joseph Flynn
Uncontrolled hypertension in children with chronic kidney disease (CKD) has been identified as one of the main factors contributing to progression of CKD and increased risk for cardiovascular disease. Recent efforts to achieve better blood pressure (BP) control have been recommended. The primary objective of this analysis was to compare BP control over 2 time periods among participants enrolled in the CKiD study (Chronic Kidney Disease in Children). Casual BP and 24-hour ambulatory BP monitor data were compared among 851 participants during 2 time periods: January 1, 2005, through July 1, 2008 (period 1, n=345), and July 1, 2010, through December 31, 2013 (period 2, n=506)...
March 2018: Hypertension
https://www.readbyqxmd.com/read/29238798/association-between-hypercoagulable-conditions-and-calciphylaxis-in-patients-with-renal-disease-a-case-control-study
#12
Allison S Dobry, Lauren N Ko, Jessica St John, J Mark Sloan, Sagar Nigwekar, Daniela Kroshinsky
Importance: Calciphylaxis is a rare skin disease with high morbidity and mortality that frequently affects patients with renal disease. Hypercoagulable conditions are frequently observed in both patients with calciphylaxis and those with chronic kidney disease (CKD), complicating our understanding of which hypercoagulable conditions are specific to calciphylaxis. Objective: To identify hypercoagulable conditions that are risk factors for developing calciphylaxis while controlling for CKD...
February 1, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29214443/contribution-of-symmetric-dimethylarginine-to-gfr-decline-in-pediatric-chronic-kidney-disease
#13
Ellen R Brooks, Shannon Haymond, Alfred Rademaker, Christopher Pierce, Irene Helenowski, Rod Passman, Faye Vicente, Bradley A Warady, Susan L Furth, Craig B Langman
BACKGROUND: In pediatric chronic kidney disease (pCKD), traditional factors (proteinuria, etiology, and race) do not fully explain disease progression. The levels of methylated arginine derivatives (MADs: asymmetric and symmetric dimethylarginine, respectively) rise in CKD and increase with CKD progression. The impact of MADs on glomerular filtration rate (GFR) decline has not been examined in pCKD. The aim of this study was to examine the additive impact of baseline (BL) levels of MADs on directly measured GFR (mGFR) decline per year (ml/min/1...
December 7, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29167082/disparities-in-health-literacy-and-healthcare-utilization-among-adolescents-and-young-adults-with-chronic-or-end-stage-kidney-disease
#14
Robyn Levine, Karina Javalkar, Meaghan Nazareth, Richard A Faldowski, Maria Diaz-Gonzalez de Ferris, Sarah Cohen, Jessica Cuttance, Stephen R Hooper, Eniko Rak
PURPOSE: Low health literacy adversely affects health outcomes in adults with chronic kidney disease. The current study examined associations between limited/inadequate health literacy and health services utilization among adolescents and young adults (AYA) with chronic or end-stage kidney disease (CKD or ESKD). DESIGN AND METHODS: This was a retrospective cohort study that enrolled patients from both the pediatric- and adult-focused nephrology clinics of a major university hospital...
January 2018: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29128412/association-between-gestational-diabetes-and-incident-maternal-ckd-the-coronary-artery-risk-development-in-young-adults-cardia-study
#15
Elizabeth W Dehmer, Milind A Phadnis, Erica P Gunderson, Cora E Lewis, Kirsten Bibbins-Domingo, Stephanie M Engel, Michele Jonsson Funk, Holly Kramer, Abhijit V Kshirsagar, Gerardo Heiss
BACKGROUND: Gestational diabetes mellitus (GDM) is associated with increased risk for diabetes mellitus, metabolic syndrome, and cardiovascular disease. We evaluated whether GDM is associated with incident chronic kidney disease (CKD), controlling for prepregnancy risk factors for both conditions. STUDY DESIGN: Prospective cohort. SETTING & PARTICIPANTS: Of 2,747 women (aged 18-30 years) enrolled in the Coronary Artery Risk Development in Young Adults (CARDIA) Study in 1985 to 86, we studied 820 who were nulliparous at enrollment, delivered at least 1 pregnancy longer than 20 weeks' gestation, and had kidney function measurements during 25 years of follow-up...
January 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29059475/incidence-of-and-risk-factors-for-severe-adverse-events-in-elderly-patients-taking-angiotensin-converting-enzyme-inhibitors-or-angiotensin-ii-receptor-blockers-after-an-acute-myocardial-infarction
#16
Gang Fang, Izabela E Annis, Joel F Farley, Nirosha Mahendraratnam, Ryan P Hickson, Til Stürmer, Jennifer G Robinson
STUDY OBJECTIVE: To assess the incidence of and risk factors associated with severe adverse events in elderly patients who used angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) after an acute myocardial infarction (AMI). DESIGN: Retrospective cohort study. DATA SOURCES: Centers for Medicare & Medicaid Services Chronic Conditions Data Warehouse (Medicare service claims database), American Community Survey of the U...
January 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/28993865/two-year-cortical-and-trabecular-bone-loss-in-ckd-5d-biochemical-and-clinical-predictors
#17
H H Malluche, M-C Monier-Faugere, G Blomquist, D L Davenport
This prospective two-year study of patients on chronic dialysis measured changes in bone mineral density (BMD). Patients with higher baseline BMD and shorter dialysis vintage lost more bone. Treatment with anti-hypertensives acting on the central nervous system was protective against bone loss. Baseline serum levels of sclerostin and bone-specific alkaline phosphatase predicted bone loss. INTRODUCTION: This prospective 2-year study of chronic kidney disease on dialysis (CKD-5D) patients assessed trabecular and cortical bone loss at the hip and spine and examined potential demographic, clinical, and serum biochemical predictors of bone loss...
January 2018: Osteoporosis International
https://www.readbyqxmd.com/read/28882358/impact-of-screening-for-metabolic-syndrome-on-the-evaluation-of-obese-living-kidney-donors
#18
Daniel P Marcusa, Douglas E Schaubel, Kenneth J Woodside, Randall S Sung
BACKGROUND: We report our experience with metabolic syndrome screening for obese living kidney donor candidates to mitigate the long-term risk of CKD. METHODS: We retrospectively reviewed 814 obese (BMI≥30) and 993 nonobese living kidney donor evaluations over 12 years. Using logistic regression, we explored interactions between social/clinical variables and candidate acceptance before and after policy implementation. RESULTS: Obese donor candidate acceptance decreased after metabolic syndrome screening began (56...
January 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/28869090/ses-chronic-kidney-disease-and-race-in-the-u-s-a-systematic-review-and-meta-analysis
#19
REVIEW
Priya Vart, Sander K R van Zon, Ron T Gansevoort, Ute Bültmann, Sijmen A Reijneveld
CONTEXT: The risk of chronic kidney disease (CKD) in the U.S. is higher in individuals with low SES than in those with high SES. However, differences in these risks between African Americans and whites are unclear. EVIDENCE ACQUISITION: Studies published through August 30, 2016 in Medline and EMBASE were searched. From the seven studies (1,775,267 participants) that met inclusion criteria, association estimates were pooled by race in meta-analysis. The ratio of association estimates and the corresponding 95% CIs for African Americans and whites were also pooled in meta-analysis...
August 28, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28865675/plasma-galectin-3-levels-are-associated-with-the-risk-of-incident-chronic-kidney-disease
#20
Casey M Rebholz, Elizabeth Selvin, Menglu Liang, Christie M Ballantyne, Ron C Hoogeveen, David Aguilar, John W McEvoy, Morgan E Grams, Josef Coresh
Galectin-3 has been proposed as a novel biomarker of heart failure and cardiac fibrosis, and may also be associated with fibrosis of other organs such as the kidney. To determine this, we prospectively analyzed data from 9,148 Atherosclerosis Risk in Communities (ARIC) Study participants with measured plasma galectin-3 levels (baseline, visit 4, 1996-98) and without prevalent chronic kidney disease (CKD) or heart failure. We identified 1,983 incident CKD cases through December 31, 2013 over a median follow-up of 16 years...
January 2018: Kidney International
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