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https://www.readbyqxmd.com/read/27901334/differential-efficacy-of-methylcobalamin-and-alpha-lipoic-acid-treatment-on-negative-and-positive-symptoms-of-type-2-diabetic-peripheral-neuropathy
#1
Yajuan Han, Min Wang, Jie Shen, Zhen Zhang, Min Zhao, Jing Huang, Youming Chen, Zhi Chen, Yulan Hu, Yubing Wang
BACKGROUND: Diabetic hyperglycemia damages peripheral nerves by triggering ischemia, oxidative stress, and inflammation. Alpha-lipoic acid (ALA) and methylcobalamin (MC) are known to improve signs of diabetic peripheral neuropathy (DPN), possibly by enhancing neural and vascular endothelial cell metabolism and antioxidant capacity. We evaluated differences in efficacy following short-term MC or ALA treatment on DPN symptoms to guide clinical drug selection. METHODS: Forty DPN patients were randomly divided into MC and ALA treatment groups (n=20/20) and assessed by the Toronto Clinical Neuropathy Scoring System (TCSS), total symptom score (TSS), visual analog scale (VAS) of positive symptoms, and easy sensory test (EST) for negative symptoms before and after 2 weeks of treatment...
November 30, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27893084/feasibility-of-clinical-endoscopy-and-stroboscopy-in-children-with-bilateral-vocal-fold-lesions
#2
Stephanie R C Zacharias, Susan Baker Brehm, Barbara Weinrich, Lisa Kelchner, Meredith Tabangin, Alessandro de Alarcon
Purpose: The purpose of this study was to examine the utility of flexible and rigid endoscopy and stroboscopy for the identification of anatomical and physiological features in children with bilateral vocal fold lesions. The secondary purpose was to describe the age distribution of patients who could tolerate use of the different types of endoscopes. Method: This cross-sectional clinic-based study included 38 children (ages 5 to 12 years) diagnosed with bilateral vocal fold lesions via videoendoscopy...
November 1, 2016: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/27831993/postoperative-symptomatic-anterior-spinal-epidural-hematoma-complete-drainage-using-corpectomy-and-a-bladder-catheter
#3
Rafael González-Diaz, Ismael Auñon-Martin, Francisco Javier Ortega-Garcia, Rui Miguel Reis da Rocha
STUDY DESIGN: A case report. OBJECTIVE: We describe a technique to drain a thoracic and cervical postoperative epidural hematoma causing paraplegia after anterior cervical discectomy and fusion. SUMMARY OF BACKGROUND DATA: Postoperative compressive spinal epidural hematoma (SEH) is a devastating complication and early diagnosis and treatment is essential. The most commonly accepted treatment is decompression and drainage of hematoma. METHODS: A 65-year-old male with a degenerative disc disease located at C4-C5, C5-C6, and C6-C7 levels with disc herniation underwent a standard anterior cervical decompression and fusion at C4-C5-C6-C7...
November 15, 2016: Spine
https://www.readbyqxmd.com/read/27807249/singing-whales-generate-high-levels-of-particle-motion-implications-for-acoustic-communication-and-hearing
#4
T Aran Mooney, Maxwell B Kaplan, Marc O Lammers
Acoustic signals are fundamental to animal communication, and cetaceans are often considered bioacoustic specialists. Nearly all studies of their acoustic communication focus on sound pressure measurements, overlooking the particle motion components of their communication signals. Here we characterized the levels of acoustic particle velocity (and pressure) of song produced by humpback whales. We demonstrate that whales generate acoustic fields that include significant particle velocity components that are detectable over relatively long distances sufficient to play a role in acoustic communication...
November 2016: Biology Letters
https://www.readbyqxmd.com/read/27798370/scaled-vibratory-feedback-can-bias-muscle-use-in-children-with-dystonia-during-a-redundant-1-dimensional-myocontrol-task
#5
Shanie A Liyanagamage, Matteo Bertucco, Nasir H Bhanpuri, Terence D Sanger
Vibratory feedback can be a useful tool for rehabilitation. We examined its use in children with dystonia to understand how it affects muscle activity in a population that does not respond well to standard rehabilitation. We predicted scaled vibration (ie, vibration that was directly or inversely proportional to muscle activity) would increase use of the vibrated muscle because of task-relevant sensory information, whereas nonscaled vibration would not change muscle use. The study was conducted on 11 subjects with dystonia and 14 controls...
October 25, 2016: Journal of Child Neurology
https://www.readbyqxmd.com/read/27798293/wall-structure-and-material-properties-cause-viscous-damping-of-swimbladder-sounds-in-the-oyster-toadfish-opsanus-tau
#6
Michael L Fine, Terrence L King, Heba Ali, Nehan Sidker, Timothy M Cameron
Despite rapid damping, fish swimbladders have been modelled as underwater resonant bubbles. Recent data suggest that swimbladders of sound-producing fishes use a forced rather than a resonant response to produce sound. The reason for this discrepancy has not been formally addressed, and we demonstrate, for the first time, that the structure of the swimbladder wall will affect vibratory behaviour. Using the oyster toadfish Opsanus tau, we find regional differences in bladder thickness, directionality of collagen layers (anisotropic bladder wall structure), material properties that differ between circular and longitudinal directions (stress, strain and Young's modulus), high water content (80%) of the bladder wall and a 300-fold increase in the modulus of dried tissue...
October 26, 2016: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/27796188/letter-to-the-editor-regarding-cardiovascular-responses-during-sexual-activity
#7
Marca Alexander, Frederique Courtois
This is a letter to the editor regarding the article: Davidson R, Elliott S, Krassioukov A. Cardiovascular Responses to Sexual Activity in Able-Bodied Individuals and Those Living with Spinal Cord Injury. May 31 epub ahead of print. The authors are commended for the detail they put in their tables; however, there are a number of areas where the authors have omitted significant published data regarding the cardiovascular responses in sexual activity in persons with spinal cord injuries. The authors have also not taken into account the N of subject in published papers that are referenced...
October 31, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27795616/the-elaborate-postural-display-of-courting-drosophila-persimilis-flies-produces-substrate-borne-vibratory-signals
#8
Mónica Vega Hernández, Caroline Cecile Gabrielle Fabre
Sexual selection has led to the evolution of extraordinary and elaborate male courtship behaviors across taxa, including mammals and birds, as well as some species of flies. Drosophila persimilis flies perform complex courtship behaviors found in most Drosophila species, which consist of visual, air-borne, gustatory and olfactory cues. In addition, Drosophila persimilis courting males also perform an elaborate postural display that is not found in most other Drosophila species. This postural display includes an upwards contortion of their abdomen, specialized movements of the head and forelegs, raising both wings into a "wing-posture" and, most remarkably, the males proffer the female a regurgitated droplet...
2016: Journal of Insect Behavior
https://www.readbyqxmd.com/read/27794340/synthetic-multi-line-kymographic-analysis-a-spatiotemporal-data-reduction-technique-for-high-speed-videoendoscopy
#9
Takeshi Ikuma, Melda Kunduk, Daniel Fink, Andrew J McWhorter
High-speed videoendoscopy (HSV) enables observation of the true vibratory behavior of the vocal folds. To quantify the vocal fold vibration captured by the HSV, lateral movement features (e.g., glottal width and vocal fold edge displacements) have been extracted as functions of time. The most common analysis method is to extract the features on a lateral strip used to form digital kymogram. The weakness of this method is that it can only capture the vibrational behavior local to the strip location. While the multi-line kymographic approach has been utilized to capture the spatial diversity, the observation points are either fixed or manually positioned...
October 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27726452/a-perceptual-study-of-the-voicing-feature-of-stop-consonants-after-type-ii-and-iii-laser-cordectomies
#10
Lucille Wallet
This article deals with the intelligibility of stop consonants in onset position (initial and intervocalic) as pronounced by 10 French speakers treated by a type II or III cordectomy. These surgeries cause a less efficient glottal closure and a vibratory asymmetry. The voicing contrast in consonants may be altered. The patients' vocal samples were made up of non-words of the CVCVCVC type, where C = /p, t, k, b, d, g/ and V = /a, i, u/(n = 360), and were given to 22 French listeners for evaluation. Two identification tests were created and the listeners were asked to choose the consonants they thought they recognized (n = 7920)...
October 11, 2016: Clinical Linguistics & Phonetics
https://www.readbyqxmd.com/read/27723847/a-multiphysics-model-of-the-pacinian-corpuscle
#11
Julia C Quindlen, Henryk K Stolarski, Matthew D Johnson, Victor H Barocas
The Pacinian corpuscle (PC) is a dermal mechanoreceptor that responds to high-frequency (20-1000 Hz) vibrations. The PC's structure allows transmission of vibrations through its layers (lamellae) to the centrally-located nerve fiber (neurite). This work combines mechanical models of the PC with an electrochemical model of peripheral nerves to simulate the tactile response of the entire system. A three-stage model of response to a vibratory input was developed, consisting of (1) outer core mechanics, (2) inner core mechanics, and (3) neurite electrochemistry...
October 10, 2016: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/27716854/comparison-of-videostroboscopy-to-stroboscopy-derived-from-high-speed-videoendoscopy-for-evaluating-patients-with-vocal-fold-mass-lesions
#12
Maria E Powell, Dimitar D Deliyski, Robert E Hillman, Steven M Zeitels, James A Burns, Daryush D Mehta
Purpose: Videostroboscopy (VS) uses an indirect physiological signal to predict the phase of the vocal fold vibratory cycle for sampling. Simulated stroboscopy (SS) extracts the phase of the glottal cycle directly from the changing glottal area in the high-speed videoendoscopy (HSV) image sequence. The purpose of this study is to determine the reliability of SS relative to VS for clinical assessment of vocal fold vibratory function in patients with mass lesions. Methods: VS and SS recordings were obtained from 28 patients with vocal fold mass lesions before and after phonomicrosurgery and 17 controls who were vocally healthy...
November 1, 2016: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/27685701/assessment-of-somatosensory-function-in-patients-with-idiopathic-dry-eye-symptoms
#13
Anat Galor, Roy C Levitt, Katherine T McManus, Jerry P Kalangara, Benjamin E Seiden, Jasmine J Park, Derek B Covington, Constantine D Sarantopoulos, Elizabeth R Felix
Importance: Somatosensory dysfunction likely underlies dry eye (DE) symptoms in many individuals yet remains an understudied component of the disease. Its presence has important diagnostic and therapeutic implications. Objective: To assess the integrity of nociceptive system processes in persons with DE and ocular pain using quantitative sensory testing (QST) techniques applied at a site remote from the eye. Design, Setting, and Participants: A cross-sectional study conducted at Miami Veterans Affairs Hospital included 118 individuals with a wide variety of DE symptoms and signs...
November 1, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27672662/vibration-induces-baff-overexpression-and-aberrant-o-glycosylation-of-iga1-in-cultured-human-tonsillar-mononuclear-cells-in-iga-nephropathy
#14
Muyao Ye, Youming Peng, Chan Liu, Wenzhe Yan, Xiaofei Peng, Liyu He, Hong Liu, Fuyou Liu
Objective. To investigate the influence of in vitro vibratory stimulation of human tonsillar mononuclear cells (TMCs). Methods. Fourteen IgA nephropathy (IgAN) patients with chronic tonsillitis (CT) and 12 CT patients with no renal pathology were enrolled. Group A TMCs were collected after 24 hours of culture and used to determine baseline levels. TMCs in groups B, C, D, E, and F were exposed to vibratory stimulation (60 Hz) for 0 (as the control group), 1, 3, 5, and 10 minutes, respectively. Results. Baseline concentrations of B-cell-activation factor (BAFF) and IgA1, BAFF mRNA expression, and aberrant O-glycosylation IgA1 level were higher in the IgAN group as compared to that in the CT group, and all increased after vibratory stimulation...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27671751/an-excised-canine-model-of-anterior-glottic-web-and-its-acoustic-aerodynamic-and-high-speed-measurements
#15
Chao Xue, Allyson Pulvermacher, William Calawerts, Erin Devine, Jack Jiang
OBJECTIVES: This study aims to build an excised anterior glottic web (AGW) model and study the basic voice-related mechanisms of the AGW through investigating the acoustic, aerodynamic, and vibratory properties. STUDY DESIGN AND METHODS: Overall, four conditions were tested for each of the eight canine larynges used. At baseline, 10%, 20%, and 33% occlusion (as determined by the placement of the suture), acoustic, aerodynamic, and high-speed video data were collected while each larynx was phonated in a soundproof booth...
September 23, 2016: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/27671247/stochastic-resonance-therapy-induces-increased-movement-related-caudate-nucleus-activity
#16
Oliver Kaut, Benjamin Becker, Christine Schneider, Feng Zhou, Klaus Fliessbach, René Hurlemann, Ullrich Wüllner
OBJECTIVE: Whole-body vibration can be used to supplement canonical physical treatment. It is performed while probands stand on a vibrating platform. Therapeutic vibration can be generated as a stochastic vibratory pattern, referred to as stochastic resonance whole-body vibration (SR-WBV). Despite the widespread use of SR-WBV its neurophysiological mechanism is unclear. DESIGN: A randomized sham-controlled double-blinded trial was performed as a pilot study. The experimental group received 6 cycles of SR-WBV at a frequency of 7 Hz with the SR-Zeptor device, and the sham group received the same treatment at a frequency of 1 Hz...
October 12, 2016: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/27649399/foot-temperature-trends-in-normal-diabetic-and-neuropathic-foot-populations
#17
Azza Alalwee, Jonathan D LeSar, Mina Ghassemi, Eugene Cheng, Steven Stuto, Lawrence Osher, Scott Bastian, Vincent J Hetherington, Jill Kawalec
INTRODUCTION AND OBJECTIVES: Patients with underlying peripheral neuropathy are subject to changes in foot temperature. (1,2) Of the many forms of neuropathy that affect the lower extremity, the most notable are those types associated with diabetes. The aim of this study was to look for differences in temperatures between uncomplicated diabetic, diabetic neuropathic, and non-diabetic neuropathic feet. METHODS: The feet of 75 subjects were divided into 3 groups: 1) normal (n=50 feet), 2) diabetic (n=50 feet), and 3) neuropathic (n=49 feet)...
September 2016: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/27633284/visualizing-the-vibration-of-laryngeal-tissue-during-phonation-using-ultrafast-plane-wave-ultrasonography
#18
Bowen Jing, Shanshan Tang, Liang Wu, Supin Wang, Mingxi Wan
Ultrafast plane wave ultrasonography is employed in this study to visualize the vibration of the larynx and quantify the vibration phase as well as the vibration amplitude of the laryngeal tissue. Ultrasonic images were obtained at 5000 to 10,000 frames/s in the coronal plane at the level of the glottis. Although the image quality degraded when the imaging mode was switched from conventional ultrasonography to ultrafast plane wave ultrasonography, certain anatomic structures such as the vocal folds, as well as the sub- and supraglottic structures, including the false vocal folds, can be identified in the ultrafast plane wave ultrasonic image...
December 2016: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/27631663/intracranial-pressure-and-promontory-vibration-with-soft-tissue-stimulation-in-cadaveric-human-whole-heads
#19
Christof Roosli, Ivo Dobrev, Jae Hoon Sim, Rahel Gerig, Flurin Pfiffner, Stefan Stenfelt, Alexander M Huber
HYPOTHESIS: Intracranial pressure and skull vibrations are correlated and depend on the stimulation position and frequency. BACKGROUND: A hearing sensation can be elicited by vibratory stimulation on the skin covered skull, or by stimulation on soft tissue such as the neck. It is not fully understood whether different stimulation sites induce the skull vibrations responsible for the perception or whether other transmission pathways are dominant. The aim of this study was to assess the correlation between intracranial pressure and skull vibration measured on the promontory for stimulation to different sites on the head...
October 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27629998/myoclonus-and-seizures-in-progressive-myoclonus-epilepsies-pharmacology-and-therapeutic-trials
#20
Roberto Michelucci, Elena Pasini, Patrizia Riguzzi, Eva Andermann, Reetta Kälviäinen, Pierre Genton
Generalized motor seizures, usually tonic-clonic, tonic-vibratory, myoclonic or clonic, and stimulus-sensitive/action myoclonus are typical features of progressive myoclonus epilepsies (PMEs). Despite the introduction of many anticonvulsants, the treatment of these symptoms, particularly myoclonus, remains challenging, due to the incomplete and often transitory effects of most drugs. Moreover, treatment is only symptomatic, since therapy targeting the underlying aetiology for these genetic conditions is in its infancy...
September 1, 2016: Epileptic Disorders: International Epilepsy Journal with Videotape
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