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https://www.readbyqxmd.com/read/28534706/analyses-of-thrombi-in-acute-ischemic-stroke-a-consensus-statement-on-current-knowledge-and-future-directions
#1
Simon F De Meyer, Tommy Andersson, Blaise Baxter, Martin Bendszus, Patrick Brouwer, Waleed Brinjikji, Bruce Cv Campbell, Vincent Costalat, Antoni Dávalos, Andrew Demchuk, Diederik Dippel, Jens Fiehler, Urs Fischer, Michael Gilvarry, Matthew J Gounis, Jan Gralla, Olav Jansen, Tudor Jovin, David Kallmes, Pooja Khatri, Kennedy R Lees, Elena López-Cancio, Charles Majoie, Henk Marquering, Ana Paula Narata, Raul Nogueira, Peter Ringleb, Adnan Siddiqui, István Szikora, David Vale, Rüdiger von Kummer, Albert J Yoo, Werner Hacke, David S Liebeskind
Limited data exist on clot composition and detailed characteristics of arterial thrombi associated with large vessel occlusion in acute ischemic stroke. Advances in endovascular thrombectomy and related imaging modalities have created a unique opportunity to analyze thrombi removed from cerebral arteries. Insights into thrombus composition, etiology, physical properties and neurovascular interactions may lead to future advancements in acute ischemic stroke treatment and improved clinical outcomes. Advances in imaging techniques may enhance clot characterization and inform therapeutic decision-making prior to treatment and reveal stroke etiology to guide secondary prevention...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28532859/humility-when-responding-to-the-abuse-of-adults-with-mental-disabilities
#2
Paul Skowron
Legal theorists often reduce the ethics of responding to the abuse of another person to a clash between the principles of autonomy and protection. This reduction is a problem. Responding to suspected abuse requires humility - the potential responder must be aware of and respect their own limits - but humility cannot be usefully reduced to protection and autonomy. Using examples from the Court of Protection of England and Wales, this article examines the different ways that someone responding to abuse should respect their own limits, and suggests that a failure to do so will disproportionately affect people with mental disabilities...
May 19, 2017: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/28531835/postpartum-acute-colonic-pseudo-obstruction-ogilvie-s-syndrome-a-systematic-review-of-case-reports-and-case-series
#3
REVIEW
Pradeep Jayaram, Manoj Mohan, Stephen Lindow, Justin Konje
INTRODUCTION: Ogilvie's Syndrome or Acute Colonic Pseudo-Obstruction (ACPO) is a rare condition characterized by massive dilatation of the colon in the absence of mechanical obstruction. About 10% of all reported cases are related to Obstetric and Gynaecological procedures, Caesarean section being the commonest associated factor. Acute intestinal dilatation, if not treated, may lead to perforation and faecal peritonitis with consequent high morbidity and mortality. MATERIALS AND METHODS: An electronic literature searches were performed in PubMed, EMBASE, Google scholar and hand searches for relevant references were included without any language restriction...
May 2, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28529392/school-composition-school-culture-and-socioeconomic-inequalities-in-young-people-s-health-multi-level-analysis-of-the-health-behaviour-in-school-aged-children-hbsc-survey-in-wales
#4
Graham F Moore, Hannah J Littlecott, Rhiannon Evans, Simon Murphy, Gillian Hewitt, Adam Fletcher
Health inequalities emerge during childhood and youth, before widening in adulthood. Theorising, testing and interrupting the mechanisms through which inequalities are perpetuated and sustained is vital. Schools are viewed as settings through which inequality in young people's health may be addressed, but few studies examine the social processes via which institutional structures reproduce or mitigate health inequalities. Informed by Markham and Aveyard's theory of human functioning and school organisation, including their concept of institutional boundaries, critical theories of marketisation and the concept of micro-political practices within schools, this paper presents analysis of student survey data (N = 9055) from 82 secondary schools in Wales...
April 2017: British Educational Research Journal
https://www.readbyqxmd.com/read/28528585/why-patients-should-be-involved-in-health-technology-assessment
#5
Janet Wale, Anna Mae Scott, Bjørn Hofmann, Sarah Garner, Eric Low, Lloyd Sansom
OBJECTIVES: Some countries make considerable effort to involve patients and patient groups in their health technology assessment (HTA) processes; others are only just considering or are yet to consider patient involvement in HTA. METHODS: This commentary offers four arguments why patient involvement should be prioritized by those HTA agencies that do not yet involve patients: (1) from a patients' rights perspective, (2) based on patient and community values, (3) centering on evidentiary contributions, and (4) from a methodological perspective...
May 22, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28527035/comparison-of-rhizosphere-properties-as-affected-by-different-bt-and-non-bt-cotton-gossypium-hirsutum-l-genotypes-and-fertilization
#6
Maqshoof Ahamd, Waleed Mumtaz Abbasi, Moazzam Jamil, Muhammad Iqbal, Azhar Hussain, Muhammad Fakhar-U-Zaman Akhtar, Farheen Nazli
Incorporation of genetically modified crops in the cropping system raises the need for studying the effect of these crops on the soil ecosystem. The current study aimed to compare the effect of Bacillus thuringiensis (Bt)- and non-Bt-cotton (Gossypium hirsutum L.) genotypes on rhizosphere properties under fertilized and unfertilized soil conditions. One non-Bt-cotton (IUB 75) and four Bt-cotton varieties (IUB-222, MM-58, IUB-13, FH-142) were sown in a Randomized Complete Block Design (RCBD) in a factorial fashion with three replications under unfertilized (T1) and fertilized (T2 at NPK 310-170-110 kg ha(-1)) soil conditions...
June 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28526329/a-behaviour-change-intervention-to-reduce-sedentary-time-in-people-with-chronic-obstructive-pulmonary-disease-protocol-for-a-randomised-controlled-trial
#7
Sonia Wing Mei Cheng, Jennifer Alison, Sarah Dennis, Emmanuel Stamatakis, Lissa Spencer, Renae McNamara, Susan Sims, Zoe McKeough
INTRODUCTION: Replacing sedentary behaviour with light intensity physical activity (ie, activities classified as less than three metabolic equivalents, such as slow-paced walking) may be a more realistic strategy for reducing cardiometabolic risk in people with chronic obstructive pulmonary disease than only aiming to increase levels of moderate-vigorous intensity physical activity. Behaviour change interventions to reduce sedentary behaviour in people with chronic obstructive pulmonary disease have not yet been developed or tested...
May 16, 2017: Journal of Physiotherapy
https://www.readbyqxmd.com/read/28525406/blood-pressure-among-australian-aboriginal-children
#8
Nicholas Larkins, Armando Teixeira-Pinto, Emily Banks, Hasantha Gunasekera, Alan Cass, Jane Kearnes, Jonathan C Craig
OBJECTIVES: To determine the prevalence of elevated blood pressure (BP) and potential predictors of SBP and DBP in urban Australian aboriginal children. METHODS: The Study of Environment on Aboriginal Resilience and Child Health is a prospective cohort study of urban Aboriginal children attending four Aboriginal Community Controlled Health Services in New South Wales, Australia. Clinical measures included a manual BP measured by research officers using standardized protocols...
May 18, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28523392/brief-report-autism-in-the-courtroom-experiences-of-legal-professionals-and-the-autism-community
#9
Katie L Maras, Laura Crane, Sue Mulcahy, Tamsyn Hawken, Penny Cooper, David Wurtzel, Amina Memon
Online surveys were used to sample the views of judges, barristers and solicitors (n = 33) about their engagement with autistic individuals in criminal courts in England and Wales. Despite an understanding of some of the difficulties experienced by individuals with autism, and the adjustments suitable for supporting them, legal professionals reported constraints arising from a lack of understanding by others within the criminal justice system. These results are considered alongside the views and perspectives of autistic adults (n = 9) and parents of children on the autism spectrum (n = 19), who had encountered the criminal courts as witnesses or defendants and were largely dissatisfied with their experiences...
May 18, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28522574/single-cell-immune-profiling-by-mass-cytometry-of-newly-diagnosed-chronic-phase-chronic-myeloid-leukaemia-treated-with-nilotinib
#10
Stein-Erik Gullaksen, Jørn Skavland, Sonia Gavasso, Vinko Tosevski, Krzysztof Warzocha, Claudia Dumrese, Augustin Ferrant, Tobias Gedde-Dahl, Andrzej Hellmann, Jeroen Janssen, Boris Labar, Alois Lang, Waleed Majeed, Georgi Mihaylov, Jesper Stentoft, Leif Stenke, Josef Thaler, Noortje Thielen, Gregor Verhoef, Jaroslava Voglova, Gert Ossenkoppele, Andreas Hochhaus, Henrik Hjorth-Hansen, Satu Mustjoki, Sieghart Sopper, Francis Giles, Kimmo Porkka, Dominik Wolf, Bjørn Tore Gjertsen
Monitoring of single cell signal transduction in leukemic cellular subsets has been proposed to provide deeper understanding of disease biology and prognostication, but has so far not been tested in a clinical trial of targeted therapy. We developed a complete mass cytometry analysis pipeline for characterization of intracellular signal transduction patterns in the major leukocyte subsets of chronic phase chronic myeloid leukaemia. Changes in phosphorylated Bcr-Abl1 and its involved signalling pathways were readily identifiable in peripheral blood single cells already within 3 hours of per oral nilotinib dosing...
May 18, 2017: Haematologica
https://www.readbyqxmd.com/read/28521386/remobilisation-of-industrial-lead-depositions-in-ash-during-australian-wildfires
#11
Liqin Wu, Mark Patrick Taylor, Heather K Handley
This study examined the recycling of lead (Pb) in ash from wildfires, its source and potential contribution to environmental contamination. Ash from wildfires was collected from four Australian sites following uncontrolled fires during 2012 to 2013 close to major urban populations in Sydney (New South Wales), Hobart (Tasmania) and Adelaide (South Australia). The samples were analysed for their total Pb concentration and Pb isotopic composition to determine the sources of Pb and the extent, if any, of industrial contamination and its recycling into the ecosystem...
May 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28520904/sources-of-unsafe-primary-care-for-older-adults-a-mixed-methods-analysis-of-patient-safety-incident-reports
#12
Alison Cooper, Adrian Edwards, Huw Williams, Huw P Evans, Anthony Avery, Peter Hibbert, Meredith Makeham, Aziz Sheikh, Liam J Donaldson, Andrew Carson-Stevens
Background: older adults are frequent users of primary healthcare services, but are at increased risk of healthcare-related harm in this setting. Objectives: to describe the factors associated with actual or potential harm to patients aged 65 years and older, treated in primary care, to identify action to produce safer care. Design and Setting: a cross-sectional mixed-methods analysis of a national (England and Wales) database of patient safety incident reports from 2005 to 2013...
May 16, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28515950/factors-associated-with-poor-self-reported-health-within-the-uk-military-and-comparisons-with-the-general-population-a-cohort-study
#13
Sarah C Jenkins, Sharon Am Stevelink, Nicola T Fear
OBJECTIVE: To investigate the self-rated health of the UK military and explore factors associated with poor self-rated health. Compare self-rated health of the military to the general population. DESIGN: A cohort study. PARTICIPANTS: A total of 7626 serving and ex-serving UK military personnel, aged between 25 and 49; 19,452,300 civilians from England and Wales. SETTING: United Kingdom (military), England and Wales (civilians)...
May 2017: JRSM Open
https://www.readbyqxmd.com/read/28515942/a-tandem-cd19-cd20-car-lentiviral-vector-drives-on-target-and-off-target-antigen-modulation-in-leukemia-cell-lines
#14
Dina Schneider, Ying Xiong, Darong Wu, Volker Nӧlle, Sarah Schmitz, Waleed Haso, Andrew Kaiser, Boro Dropulic, Rimas J Orentas
BACKGROUND: Clinical success with chimeric antigen receptor (CAR)- based immunotherapy for leukemia has been accompanied by the associated finding that antigen-escape variants of the disease are responsible for relapse. To target hematologic malignancies with a chimeric antigen receptor (CAR) that targets two antigens with a single vector, and thus potentially lessen the chance of leukemic escape mutations, a tandem-CAR approach was investigated. METHODS: Antigen binding domains from the FMC63 (anti-CD19) and Leu16 (anti-CD20) antibodies were linked in differing configurations to transmembrane and T cell signaling domains to create tandem-CARs...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28515856/inter-ethnic-marriages-and-severity-of-coronary-artery-disease-a-multicenter-study-of-arabian-gulf-states
#15
Amin Daoulah, Salem Al-Kaabi, Amir Lotfi, Mushabab Al-Murayeh, S Ali Nasseri, Waleed Ahmed, Salah N Al-Otaibi, Mohamed N Alama, Osama E Elkhateeb, Amy J Plotkin, Majed M Malak, Khalid Alshali, Mohamed Hamzi, Saleh Al Khunein, Mohammed Abufayyah, Alawi A Alsheikh-Ali
AIM: To assess the association of inter-ethnic vs intra-ethnic marriage with severity of coronary artery disease (CAD) in men undergoing angiography. METHODS: We conducted a prospective multicenter, multi-ethnic, cross sectional observational study at five hospitals in Saudi Arabia and the United Arab Emirates, in which we used logistic regression analysis with and without adjustment for baseline differences. RESULTS: Data were collected for 1068 enrolled patients undergoing coronary angiography for clinical indications during the period of April 1(st), 2013 to March 30(th), 2014...
April 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28514961/how-many-people-will-need-palliative-care-in-2040-past-trends-future-projections-and-implications-for-services
#16
S N Etkind, A E Bone, B Gomes, N Lovell, C J Evans, I J Higginson, F E M Murtagh
BACKGROUND: Current estimates suggest that approximately 75% of people approaching the end-of-life may benefit from palliative care. The growing numbers of older people and increasing prevalence of chronic illness in many countries mean that more people may benefit from palliative care in the future, but this has not been quantified. The present study aims to estimate future population palliative care need in two high-income countries. METHODS: We used mortality statistics for England and Wales from 2006 to 2014...
May 18, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28514953/emergence-of-babesia-canis-in-southern-england
#17
Maria Del Mar Fernández de Marco, Luis M Hernández-Triana, L Paul Phipps, Kayleigh Hansford, E Sian Mitchell, Ben Cull, Clive S Swainsbury, Anthony R Fooks, Jolyon M Medlock, Nicholas Johnson
BACKGROUND: The United Kingdom is considered free of autochthonous transmission of canine babesiosis although cases are reported in dogs associated with recent travel abroad. During the winter months of 2015/16, a cluster of cases of disease in dogs with signs suggestive of canine babesiosis were reported in Harlow, Essex. METHODS: Babesia species were detected in dog blood samples by Giemsa staining of blood smears and by pan-piroplasm PCRs. Babesia species were also detected in extracts of tick DNA using pan-piroplasm PCRs...
May 17, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28513363/wales-keeps-a-welcome-for-students
#18
(no author information available yet)
A campaign has been launched promoting Wales as a place for nurses to train, work and live.
May 17, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28511736/dietary-salt-intake-in-the-australian-population
#19
Joseph Alvin Santos, Jacqui Webster, Mary-Anne Land, Victoria Flood, John Chalmers, Mark Woodward, Bruce Neal, Kristina S Petersen
OBJECTIVE: To update the estimate of mean salt intake for the Australian population made by the Australian Health Survey (AHS). DESIGN: A secondary analysis of the data collected in a cross-sectional survey was conducted. Estimates of salt intake were made in Lithgow using the 24 h diet recall methodology employed by the AHS as well as using 24 h urine collections. The data from the Lithgow sample were age- and sex-weighted, to provide estimates of daily salt intake for the Australian population based upon (i) the diet recall data and (ii) the 24 h urine samples...
May 17, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28511734/sleeping-with-one-eye-open-loneliness-and-sleep-quality-in-young-adults
#20
T Matthews, A Danese, A M Gregory, A Caspi, T E Moffitt, L Arseneault
BACKGROUND: Feelings of loneliness are common among young adults, and are hypothesized to impair the quality of sleep. In the present study, we tested associations between loneliness and sleep quality in a nationally representative sample of young adults. Further, based on the hypothesis that sleep problems in lonely individuals are driven by increased vigilance for threat, we tested whether past exposure to violence exacerbated this association. METHOD: Data were drawn from the Environmental Risk (E-Risk) Longitudinal Twin Study, a birth cohort of 2232 twins born in England and Wales in 1994 and 1995...
May 17, 2017: Psychological Medicine
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