keyword
MENU ▼
Read by QxMD icon Read
search

Lead extraction

keyword
https://www.readbyqxmd.com/read/29915766/comparing-the-effects-of-shallomin-lotion-and-cryotherapy-on-treating-plane-warts
#1
Reza Yaaghubi, Mohammad Hassan Pipelzade, Mansur Amin, Mohammad Ali Shakeri Hosseinabad
Background: Wart is a common transferable skin disease that is caused by human papilloma virus. Choosing the best treatment method can vary based on age, therapeutic goal, complications, and wart place. Due to antibacterial effect of shallomin (hirtifolium Boiss extract) and since its effect has not been studied yet, it was compared to cryotherapy therapeutic methods for treating patients with plane warts. Methods: The present study was a randomized clinical trial that was carried out on 40 patients...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29915575/gingival-periodontal-disease-pd-level-butyric-acid-affects-the-systemic-blood-and-brain-organ-insights-into-the-systemic-inflammation-of-periodontal-disease
#2
Marni E Cueno, Kuniyasu Ochiai
Butyric acid (BA) is produced by periodontopathic bacterial pathogens and contributes to periodontal disease (PD) induction. Moreover, PD has been associated with detrimental effects which subsequently may lead to systemic disease (SD) development affecting certain organs. Surprisingly, the potential systemic manifestations and organ-localized effects of BA have never been elucidated. Here, we simulated BA-based oral infection among young (20-week-old) rats and isolated blood cytosol to determine BA effects on stress network-related signals [total heme, hydrogen peroxide (H2 O2 ), catalase (CAT), glutathione reductase (GR), free fatty acid (FFA), NADP/NADPH], inflammation-associated signals [caspases (CASP12 and CASP1), IL-1β, TNF-α, metallomatrix proteinase-9 (MMP-9), and toll-like receptor-2 (TLR2)], and neurological blood biomarkers [presenilin (PS1 and PS2) and amyloid precursor protein (APP)]...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29914539/evaluation-of-the-hoxa11-level-in-patients-with-lung-squamous-cancer-and-insights-into-potential-molecular-pathways-via-bioinformatics-analysis
#3
Rui Zhang, Tong-Tong Zhang, Gao-Qiang Zhai, Xian-Yu Guo, Yuan Qin, Ting-Qing Gan, Yu Zhang, Gang Chen, Wei-Jia Mo, Zhen-Bo Feng
BACKGROUND: This study was carried out to discover the underlying role that HOXA11 plays in lung squamous cancer (LUSC) and uncover the potential corresponding molecular mechanisms and functions of HOXA11-related genes. METHODS: Twenty-three clinical paired LUSC and non-LUSC samples were utilized to examine the level of HOXA11 using quantitative real-time polymerase chain reaction (qRT-PCR). The clinical significance of HOXA11 was systematically analyzed based on 475 LUSC and 18 non-cancerous adjacent tissues from The Cancer Genome Atlas (TCGA) database...
June 18, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29914183/graviola-annona-muricata-exerts-anti-proliferative-anti-clonogenic-and-pro-apoptotic-effects-in-human-non-melanoma-skin-cancer-uw-bcc1-and-a431-cells-in-vitro-involvement-of-hedgehog-signaling
#4
Jean Christopher Chamcheu, Islam Rady, Roxane-Cherille N Chamcheu, Abu Bakar Siddique, Melissa B Bloch, Sergette Banang Mbeumi, Abiola S Babatunde, Mohammad B Uddin, Felicite K Noubissi, Peter W Jurutka, Yong-Yu Liu, Vladimir S Spiegelman, G Kerr Whitfield, Khalid A El Sayed
Non-melanoma skin cancers (NMSCs) are the leading cause of skin cancer-related morbidity and mortality. Effective strategies are needed to control NMSC occurrence and progression. Non-toxic, plant-derived extracts have been shown to exert multiple anti-cancer effects. Graviola ( Annona muricata ), a tropical fruit-bearing plant, has been used in traditional medicine against multiple human diseases including cancer. The current study investigated the effects of graviola leaf and stem extract (GLSE) and its solvent-extracted fractions on two human NMSC cell lines, UW-BCC1 and A431...
June 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29913231/a-systematic-review-and-meta-analysis-of-metal-concentrations-in-canned-tuna-fish-in-iran-and-human-health-risk-assessment
#5
Jamal Rahmani, Yadolah Fakhri, Ali Miri, Abbas Shahsavani, Zohreh Bahmani, Mauricio A Urbina, Salvatore Chirumbolo, Hassan Keramati, Bigard Moradi, Abotaleb Bay, Geir Bjørklund
Human consumption of fish protein, including canned tuna fish, is increasing steadily worldwide. However, there are some concerns about the potential exposure to elevated concentrations of metals in canned tuna fish. Several studies have been conducted in Iran regarding the concentration of metals in seafood, including copper (Cu), selenium (Se), iron (Fe), zinc (Zn), mercury (Hg), lead (Pb), chromium (Cr), arsenic (As), nickel (Ni), tin (Sn), and cadmium (Cd) in canned tuna fish. The main aim of this study was to gather data from existing papers and to perform a meta-analysis of the pooled concentrations of metals to evaluate their non-carcinogenic and carcinogenic risks in children and adults consumers...
June 15, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29912953/seasonal-variations-in-diet-composition-diet-breadth-and-dietary-overlap-between-three-commercially-important-fish-species-within-a-flood-pulse-system-the-tonle-sap-lake-cambodia
#6
Kong Heng, Mathieu Chevalier, Sovan Lek, Pascal Laffaille
Tropical lakes and their associated floodplain habitats are dynamic habitat mosaics strongly influenced by seasonal variations in hydrologic conditions. In flood-pulse systems, water level oscillations directly influence the connectivity to floodplain habitats for fish. Here, we aimed to investigate whether seasonal changes in the water level of a flood-pulse system (the Tonle Sap Lake, Cambodia) differentially affect diet breadth and dietary overlap of three common and commercially important fish species (Anabas testudineus, Boesemania microplepis and Notopterus notopterus) presenting important differences in their life-cycle (e...
2018: PloS One
https://www.readbyqxmd.com/read/29912824/the-natural-history-and-rehabilitative-outcomes-of-hearing-loss-in-congenital-cytomegalovirus-a-systematic-review
#7
Kyle T Fletcher, Erin M Wolf Horrell, John Ayugi, Catherine Irungu, Maria Muthoka, Liza M Creel, Cathy Lester, Matthew L Bush
OBJECTIVE: The purpose of this study was to examine the literature regarding the natural history and rehabilitative outcomes of sensorineural hearing loss from congenital cytomegalovirus infections. DATA SOURCES AND STUDY ELIGIBILITY CRITERIA: A systematic search was performed in PubMed, PsychINFO, CINAHL, and Web of Science to identify peer-reviewed research. Eligible studies were those containing original peer-reviewed research in English addressing either the natural history or rehabilitative outcomes of sensorineural hearing loss (SNHL) in congenital cytomegalovirus (cCMV)...
June 15, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29911067/molar-protraction-using-miniscrews-temporary-anchorage-device-with-simultaneous-correction-of-lateral-crossbite-an-orthodontic-case-report
#8
Kavitha Odathurai Marusamy, Saravanan Ramasamy, Othman Wali
Early loss of permanent teeth, congenitally missing lateral incisors or second premolars, extremely displaced or impacted canines, all result in a reduced upper dentition. That leads to the development of crossbite in the maxillary dentition. Partial denture prosthesis, dental implants, and space closure by fixed orthodontics are the various means of treating the edentulous spaces. Protraction of molars is time taking and challenging. Temporary anchorage device (TAD) helps to protract molars without anchorage loss...
May 2018: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29910706/less-might-be-more-conduction-failure-as-a-factor-possibly-limiting-the-efficacy-of-higher-frequencies-in-rtms-protocols
#9
Islam Halawa, Amir Goldental, Yuichiro Shirota, Ido Kanter, Walter Paulus
Introduction: rTMS has been proven effective in the treatment of neuropsychiatric conditions, with class A (definite efficacy) evidence for treatment of depression and pain (Lefaucheur et al., 2014). The efficacy in stimulation protocols is, however, quite heterogeneous. Saturation of neuronal firing by HFrTMS without allowing time for recovery may lead to neuronal response failures (NRFs) that compromise the efficacy of stimulation with higher frequencies. Objectives: To examine the efficacy of different rTMS temporal stimulation patterns focusing on a possible upper stimulation limit related to response failures...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29909569/economic-burden-of-stroke-a-systematic-review-on-post-stroke-care
#10
S Rajsic, H Gothe, H H Borba, G Sroczynski, J Vujicic, T Toell, Uwe Siebert
OBJECTIVES: Stroke is a leading cause for disability and morbidity associated with increased economic burden due to treatment and post-stroke care (PSC). The aim of our study is to provide information on resource consumption for PSC, to identify relevant cost drivers, and to discuss potential information gaps. METHODS: A systematic literature review on economic studies reporting PSC-associated data was performed in PubMed/MEDLINE, Scopus/Elsevier and Cochrane databases, Google Scholar and gray literature ranging from January 2000 to August 2016...
June 16, 2018: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/29909120/integrated-in-silico-in-vitro-strategy-for-screening-of-some-traditional-egyptian-plants-for-human-aromatase-inhibitors
#11
Hend M Dawood, Reham S Ibrahim, Eman Shawky, Hala M A Hammoda, Aly M Metwally
ETHNOPHARMACOLOGICAL RELEVANCE: Aromatase enzyme (CYP19) is widely known as a critical target protein for treating hormone-dependent breast cancer. Natural products from traditional medicinal plants continue to be an active source of aromatase inhibitors. Meanwhile, high cost of experimental work and low hit rate associated with HTS have stimulated the implementation of in-silico virtual screening to resolve these pitfalls, where coupling of both classical wet lab procedure and VS may offer a more deepened access to bioactive compounds with less work and time waste...
June 14, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29908914/high-level-expression-and-enrichment-of-norovirus-virus-like-particles-in-plants-using-modified-geminiviral-vectors
#12
Andrew G Diamos, Hugh S Mason
Recombinant virus-like particles (VLPs) are proven to be safe and effective vaccine candidates. We have previously described a plant-based recombinant protein expression system based on agroinfiltration of a replicating vector derived from the geminivirus bean yellow dwarf virus (BeYDV). The system has been systematically optimized to improve expression and reduce cell death in Nicotiana benthamiana leaves. Using these modifications, we show that VLPs derived from genotype GII.4 norovirus, the leading cause of acute gastroenteritis worldwide, can be produced at >1 mg/g leaf fresh weight (LFW), over three times the highest level ever reported in plant-based systems...
June 14, 2018: Protein Expression and Purification
https://www.readbyqxmd.com/read/29908539/the-effects-of-allium-cepa-extract-on-tracheal-responsiveness-lung-inflammatory-cells-and-phospholipase-a2-level-in-asthmatic-rats
#13
Vahideh Ghorani, Narges Marefati, Farzaneh Shakeri, Ramin Rezaee, Marzie Boskabady, Mohammad Hossein Boskabady
Antioxidant, antimicrobial, anti-hyperglycaemic, anti-diabetic and anti-inflammatory effects of Allium cepa (A. cepa) have been previously shown. In this study, the effects of A. cepa aqueous-alcoholic extract on tracheal responsiveness, lung inflammatory cells and phospholipase A2 (PLA2) level in bronchoalveolar fluid (BALF) of asthmatic rats were examined. Wistar rats were randomly divided into control group (C), asthmatic group (A), asthmatic group (A) treated with A. cepa extract (AC, 0.175, 0.35, and 0...
June 2018: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29908468/first-report-on-the-pharmacokinetic-profile-of-nimbolide-a-novel-anticancer-agent-in-oral-and-intravenous-administrated-rats-by-lc-ms-method
#14
Shandilya Mahamuni Baira, Amit Khurana, Jaganmohan Somagoni, R Srinivas, Chandraiah Godugu, M V N Kumar Talluri
Nimbolide is a novel, natural compound with promising potential as a drug candidate for anticancer activity. It is isolated from the Indian traditional medicinal plant Azadirachta indica popularly known as neem. The present study was undertaken to explore the oral bioavailability and pharmacokinetic characteristics of nimbolide in rats using the LC/QTOF/MS method. A simple protein precipitation method using acetonitrile was employed for extracting nimbolide from rat plasma. The chromatographic separation of nimbolide and the internal standard (regorafenib) was attained on an Aquity BEH C18 column (100 × 2...
June 2, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29908160/pseudo-phosphorylation-at-at8-epitopes-regulates-the-tau-truncation-at-aspartate-421
#15
Lan Cao, Yan Liang, Yunsheng Liu, Yuxia Xu, Wenbin Wan, Cuiqing Zhu
Tau pathology in Alzheimer's disease (AD) includes hyperphosphorylation and truncation of tau. Phosphorylation at S422 is found to suppress truncation of tau at D421 that leading to the generation of ΔTau. However, the interrelation between hyperphosphorylation and generation of ΔTau in AD remains elusive. In current study, staurosporine (Stau) induced ΔTau generation by caspases in SH-SY5Y cells with tau overexpression was found to be accompanied by a dramatic dephosphorylation at S422 and the epitope of the diagnostic antibody AT8 (S199+S202+T205), but a moderate dephosphorylation of PHF1 (S396+S404) epitope...
June 13, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29907215/abnormal-lymphocyte-response-after-pediatric-thermal-injury-is-associated-with-adverse-outcomes
#16
Rajan K Thakkar, Zachary Diltz, Joseph D Drews, Krista K Wheeler, Junxin Shi, Racheal Devine, Renata Fabia, Mark Hall
BACKGROUND: Burns are a leading cause of morbidity in children, with infections representing the most common group of complications. Severe thermal injuries are associated with a profound inflammatory response, but the utility of laboratory values to predict infections in pediatric burn patients is poorly understood. MATERIALS AND METHODS: Our institutional burn database was queried for patients aged 18 y and younger with at least 10% total body surface area burns...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29906322/dressings-and-topical-agents-for-treating-venous-leg-ulcers
#17
REVIEW
Gill Norman, Maggie J Westby, Amber D Rithalia, Nikki Stubbs, Marta O Soares, Jo C Dumville
BACKGROUND: Venous leg ulcers are open skin wounds on the lower leg which can be slow to heal, and are both painful and costly. The point prevalence of open venous leg ulcers in the UK is about 3 cases per 10,000 people, and many people experience recurrent episodes of prolonged ulceration. First-line treatment for venous leg ulcers is compression therapy, but a wide range of dressings and topical treatments are also used. This diversity of treatments makes evidence-based decision-making challenging, and a clear and current overview of all the evidence is required...
June 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29905355/-radiomics-big-data-instead-of-biopsies-in-the-future
#18
Kathrin Scheckenbach
Precision medicine is increasingly pushed forward, also with respect to upcoming new targeted therapies. Individual characterization of diseases on the basis of biomarkers is a prerequisite for this development. So far, biomarkers are characterized clinically, histologically or on a molecular level. The implementation of broad screening methods ("Omics") and the analysis of big data - in addition to single markers - allow to define biomarker signatures. Next to "Genomics", "Proteomics", and "Metabolicis", "Radiomics" gained increasing interest during the last years...
March 2018: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29905073/biodegradable-transparent-substrate-based-on-edible-starch-chitosan-embedded-with-nature-inspired-three-dimensionally-interconnected-conductive-nanocomposites-for-wearable-green-electronics
#19
Jinlei Miao, Haihui Liu, Yongbing Li, Xingxiang Zhang
Electronic waste (E-waste) contain large environmental contaminants such as toxic heavy metals and hazardous chemicals. These contaminants would migrate into drinking water or food chains and pose a serious threat to environment and human health. Biodegradable green electronics has great potential to address the issue of E-waste. Here we report on a novel biodegradable and flexible transparent electrode, integrate three-dimensionally (3D) interconnected conductive nanocomposites into edible starch-chitosan based substrates...
June 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29904155/moringin-induces-neural-differentiation-in-the-stem-cell-of-the-human-periodontal-ligament
#20
Letizia Romeo, Francesca Diomede, Agnese Gugliandolo, Domenico Scionti, Fabrizio Lo Giudice, Veronica Lanza Cariccio, Renato Iori, Placido Bramanti, Oriana Trubiani, Emanuela Mazzon
The therapeutic strategies for neurodegenerative diseases still represent a vast research field because of the lack of targeted, effective and resolutive treatment for neurodegenerative diseases. The use of stem cell-based therapy is an alternative approach that could lead to the replacement of damaged neuronal tissue. For this purpose, adult mesenchymal stem cells (MSC), including periodontal ligament stem cells (PDLSCs), could be very useful for their differentiation capacity, easy isolation and the ability to perform an autologous implant...
June 14, 2018: Scientific Reports
keyword
keyword
8949
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"