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https://www.readbyqxmd.com/read/28087102/feature-selection-for-outcome-prediction-in-oesophageal-cancer-using-genetic-algorithm-and-random-forest-classifier
#1
Desbordes Paul, Ruan Su, Modzelewski Romain, Vauclin Sébastien, Vera Pierre, Gardin Isabelle
The outcome prediction of patients can greatly help to personalize cancer treatment. A large amount of quantitative features (clinical exams, imaging, …) are potentially useful to assess the patient outcome. The challenge is to choose the most predictive subset of features. In this paper, we propose a new feature selection strategy called GARF (genetic algorithm based on random forest) extracted from positron emission tomography (PET) images and clinical data. The most relevant features, predictive of the therapeutic response or which are prognoses of the patient survival 3 years after the end of treatment, were selected using GARF on a cohort of 65 patients with a local advanced oesophageal cancer eligible for chemo-radiation therapy...
December 28, 2016: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/28086992/therapies-for-bruxism-a-systematic-review-and-network-meta-analysis-protocol
#2
Mauro Elias Mesko, Brian Hutton, Jovito Adiel Skupien, Rafael Sarkis-Onofre, David Moher, Tatiana Pereira-Cenci
BACKGROUND: Bruxism is a sleep disorder characterized by grinding and clenching of the teeth that may be related to irreversible tooth injuries. It is a prevalent condition occurring in up to 31% of adults. However, there is no definitive answer as to which of the many currently available treatments (including drug therapy, intramuscular injections, physiotherapy, biofeedback, kinesiotherapy, use of intraoral devices, or psychological therapy) is the best for the clinical management of the different manifestations of bruxism...
January 13, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28086782/in-vivo-antiplasmodial-activity-and-toxicological-assessment-of-hydroethanolic-crude-extract-of-ajuga-remota
#3
Aschalew Nardos, Eyasu Makonnen
BACKGROUND: Malaria is one of the most life-threatening health problems worldwide and treatment has been compromised by drug resistance. Identifying lead molecules from natural products might help to find better anti-malarial drugs, since those obtained from natural sources are still effective against malarial parasites. This study aimed at investigating the in vivo antiplasmodial activity of crude extract of the leaves of Ajuga remota together with its safety in mice models. METHODS: In vivo parasite growth inhibitory effect of crude extract was assessed in mice inoculated with Plasmodium berghei (ANKA strain)...
January 13, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28079831/gastric-cancer-burden-of-last-40-years-in-north-china-hebei-province-a-population-based-study
#4
Di Liang, Suoyuan Liang, Jing Jin, Daojuan Li, Jin Shi, Yutong He
Gastric cancer (GC) is the second leading cause of cancer death in China. It is well known that Cixian in Hebei Province is one of the highest risk areas of GC in China and worldwide. This study aims to accurate assessment of GC burden and trend in high-risk area (Hebei Province) from 1973 to 2013. The authors analyzed GC data from 21 population-based cancer registries which represented 15.25% of the entire population of Hebei Province. The collected data were stratified by 5-year age groups, gender, and area...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28079279/evaluating-predictors-of-lead-exposure-for-activities-disturbing-materials-painted-with-or-containing-lead-using-historic-published-data-from-u-s-workplaces
#5
Sarah J Locke, Nicole C Deziel, Dong-Hee Koh, Barry I Graubard, Mark P Purdue, Melissa C Friesen
OBJECTIVES: We evaluated predictors of differences in published occupational lead concentrations for activities disturbing material painted with or containing lead in U.S. workplaces to aid historical exposure reconstruction. METHODS: For the aforementioned tasks, 221 air and 113 blood lead summary results (1960-2010) were extracted from a previously developed database. Differences in the natural log-transformed geometric mean (GM) for year, industry, job, and other ancillary variables were evaluated in meta-regression models that weighted each summary result by its inverse variance and sample size...
February 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28078810/anti-hcv-activity-from-semi-purified-methanolic-root-extracts-of-valeriana-wallichii
#6
Krishna Kumar Ganta, Anirban Mandal, Sukalyani Debnath, Banasri Hazra, Binay Chaubey
Hepatitis C virus (HCV) is a serious global health problem affecting approximately 130-150 million individuals. Presently available direct-acting anti-HCV drugs have higher barriers to resistance and also improved success rate; however, cost concerns limit their utilization, especially in developing countries like India. Therefore, development of additional agents to combat HCV infection is needed. In the present study, we have evaluated anti-HCV potential of water, chloroform, and methanol extracts from roots of Valeriana wallichii, a traditional Indian medicinal plant...
January 12, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28078508/prioritization-of-liver-mri-for-distinguishing-focal-lesions
#7
Qinghua Su, Shusheng Bi, Xuedong Yang
Liver cancer is one of the leading causes of cancer-related mortality worldwide. Magnetic resonance imaging (MRI) is a non-invasive imaging technique that is often used by radiologists for diagnosis and surgical planning. Analysis of a large amount of liver MRI data for each patient limits the radiologist's efficiency and may lead to misdiagnoses. The redundant MRI data, especially from dynamic contrast enhanced (DCE) sequences, is also a bottleneck in transmitting the images via the internet or PACS for remote consultancy in a reasonable amount of time...
January 4, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28077109/cause-of-neonatal-deaths-in-northern-ethiopia-a-prospective-cohort-study
#8
Hayelom Gebrekirstos Mengesha, Berhe W Sahle
BACKGROUND: Despite the significant reduction in childhood mortality, neonatal mortality has shown little or no concomitant decline worldwide. The dilemma arises in that the lack of documentation of cause of death in developing countries, where registration of vital events is virtually nonexistent. Understanding of the causes of death in neonates is important to guide public health interventions. The present study identifies the common causes of neonatal death in Ethiopia. METHODS: A prospective cohort study was conducted among neonates born between April 2014 and July 2014 in seven hospitals, in Tigray region, Ethiopia...
January 11, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28075624/use-of-preprocedural-mdct-for-cardiac-implantable-electric-device-lead-extraction-frequency-of-findings-that-change-management
#9
Wendy L Ehieli, Daniel T Boll, Daniele Marin, Robert Lewis, Jonathan P Piccini, Lynne M Hurwitz
OBJECTIVE: Five percent of cardiac implantable electric devices (CIEDs) are removed each year. Percutaneous extraction is preferred but can be complicated if the leads adhere to the vasculature or perforate. The goal of this study is to assess the frequency of findings on dedicated MDCT that alter preprocedural planning for percutaneous CIED extraction. MATERIALS AND METHODS: One hundred patients with CIEDs who underwent MDCT before percutaneous lead extraction were analyzed...
January 11, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28074952/upregulation-of-caveolin-1-by-mulberry-leaf-extract-and-its-major-components-chlorogenic-acid-derivatives-attenuates-alcoholic-steatohepatitis-via-inhibition-of-oxidative-stress
#10
Yi-Ju Lee, Jeng-Dong Hsu, Wea-Lung Lin, Shao-Hsuan Kao, Chau-Jong Wang
Excessive alcohol uptake exerts hepatocellular toxicity, ultimately leading to multiple liver diseases such as steatohepatitis and liver cirrhosis. Here, we aimed to explore the effects of mulberry leaf extract (MLE) and its major components chlorogenic acid (CGA) and neochlorogenic acid (nCGA) on alcoholic steatohepatitis. We determined the composition of MLE using liquid chromatography-mass spectrometric (LC-MS) analysis, which showed that MLE consisted of mainly chlorogenic acid derivatives and other polyphenols...
January 11, 2017: Food & Function
https://www.readbyqxmd.com/read/28073942/emergency-department-visits-related-to-functional-abdominal-pain-in-the-pediatric-age-group
#11
Chaitanya Pant, Abhishek Deshpande, Thomas J Sferra, Mojtaba Olyaee
To analyze visits to and admissions from the emergency department (ED) in children with a primary diagnosis of functional abdominal pain (FAP). This was a cross-sectional study using data from the Nationwide Emergency Department Sample (HCUP-NEDS 2008-2012). FAP-related ED visits were identified using International Classification of Diseases, Ninth Revision, Clinical Modification codes. The most frequent secondary diagnoses associated with FAP-related ED visits were also extracted. In 2012, a total of 796,665 children presented to the ED with a primary diagnosis of FAP...
January 10, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28073678/natural-potential-neuroinflammatory-inhibitors-from-alhagi-sparsifolia-shap
#12
Di Zhou, Hongyan Wei, Zhe Jiang, Xuezheng Li, Kun Jiao, Xiaoguang Jia, Yue Hou, Ning Li
Neuroinflammation is a key contributor to neuronal damage in neurodegenerative diseases. In our previous work on natural effective neuroinflammatory inhibitors, Alhagi sparsifolia Shap. (Leguminosae), a folk medicine widely distributed in Xinjiang, attracted our attention because of its significant anti-neuroinflammatory effect. Therefore, further investigation of the bioactive material basis was carried out. As a result, 33 major components were characterized and identified by chromatographic and spectral methods, respectively...
December 30, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28073461/assessing-in-situ-dominance-pattern-of-phytoplankton-classes-by-dominance-analysis-as-a-proxy-for-realized-niches
#13
Susanne Dunker, Karin Nadrowski, Torsten Jakob, Peter Kasprzak, Annette Becker, Uwe Langner, Christfried Kunath, Stan Harpole, Christian Wilhelm
This study looks at two facets of dominant phytoplankton classes during phytoplankton succession. A detailed assessment of this issue is of special interest with regard to realized niches from a theoretical point of view but also for lake management as practical application. A realized niche mirrors the functional adaptability of an organism in a lake-specific constellation of environmental parameters. Therefore, the characterization of realized niches could be a key factor for management of problematic waters...
September 2016: Harmful Algae
https://www.readbyqxmd.com/read/28073178/polyclonal-and-monoclonal-antibodies-for-induction-therapy-in-kidney-transplant-recipients
#14
REVIEW
Penny Hill, Nicholas B Cross, A Nicholas R Barnett, Suetonia C Palmer, Angela C Webster
BACKGROUND: Prolonging kidney transplant survival is an important clinical priority. Induction immunosuppression with antibody therapy is recommended at transplantation and non-depleting interleukin-2 receptor monoclonal antibodies (IL2Ra) are considered first line. It is suggested that recipients at high risk of rejection should receive lymphocyte-depleting antibodies but the relative benefits and harms of the available agents are uncertain. OBJECTIVES: We aimed to: evaluate the relative and absolute effects of different antibody preparations (except IL2Ra) when used as induction therapy in kidney transplant recipients; determine how the benefits and adverse events vary for each antibody preparation; determine how the benefits and harms vary for different formulations of antibody preparation; and determine whether the benefits and harms vary in specific subgroups of recipients (e...
January 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28072821/maysin-and-its-flavonoid-derivative-from-centipedegrass-attenuates-amyloid-plaques-by-inducting-humoral-immune-response-with-th2-skewed-cytokine-response-in-the-tg-appswe-ps1de9-alzheimer-s-mouse-model
#15
Yuno Song, Hong-Duck Kim, Min-Kwon Lee, Il-Hwa Hong, Chung-Kil Won, Hyoung-Woo Bai, Seung Sik Lee, SungBeom Lee, Byung Yeoup Chung, Jae-Hyeon Cho
Alzheimer's disease (AD) is a slow, progressive neurodegenerative disease and the most common type of dementia in the elderly. The etiology of AD and its underlying mechanism are still not clear. In a previous study, we found that an ethyl acetate extract of Centipedegrass (CG) (i.e., EA-CG) contained 4 types of Maysin derivatives, including Luteolin, Isoorientin, Rhamnosylisoorientin, and Derhamnosylmaysin, and showed protective effects against Amyloid beta (Aβ) by inhibiting oligomeric Aβ in cellular and in vitro models...
2017: PloS One
https://www.readbyqxmd.com/read/28071865/the-impact-of-evidence-based-sepsis-guidelines-on-emergency-department-clinical-practice-a-pre-post-medical-record-audit
#16
Bernadine Romero, Margaret Fry, Michael Roche
AIMS AND OBJECTIVES: The aim of this study was to explore the number of patients presenting with sepsis before and after guideline implementation; the impact of sepsis guidelines on triage assessment, Emergency Department management and time to antibiotics. BACKGROUND: Sepsis remains one of the leading causes of mortality and morbidity within hospitals. Globally, strategies have been implemented to reduce morbidity and mortality rates, which rely on the early recognition and management of sepsis...
January 10, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28070533/quantification-of-pla-or-3-a-platanus-orientalis-allergen-grown-under-different-environmental-conditions-by-sandwich-elisa
#17
Sedghy Farnaz, Sankian Mojtaba, Moghadam Maliheh, Varasteh Abdol-Reza
BACKGROUND: Platanus species are widely cultured around the world and considered an important cause of allergic reactions. In the present study, we developed a sandwich ELISA to quantify Pla or 3 allergen in P. orientalis pollen extracts grown near high-traffic roads and compared it to pollen extracts collected from rural areas as control. METHODS: Pollen samples were collected from three polluted and two unpolluted sites in Mashhad, northeast Iran. Recombinant Pla or 3 was expressed and used for polyclonal antibody production in rabbit...
October 2016: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28068861/a-reformative-shear-precipitation-procedure-for-the-fabrication-of-vancomycin-loaded-poly-lactide-co-glycolide-microspheres
#18
Lei Wang, Qinmeng Yang, Yirong Chen, Yu Chai, Jiao Jiao Li, Lin Du, Ruizhe Tan, Shenyu Yang, Mei Tu, Bin Yu
This study reports the encapsulation of vancomycin, as a model hydrophilic drug, into poly(lactide-co-glycolide) microspheres using a novel reformative shear precipitation procedure. In contrast to the external aqueous phase used in the conventional microencapsulation technique based on emulsion solvent evaporation/extraction, the reformative shear precipitation procedure explored in this study uses a shear medium composed of glycerol as the viscous medium and ethanol as polymer antisolvent, which is relatively immiscible with the hydrophilic drug...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28068633/polyphenol-rich-ethanolic-extract-from-boerhavia-diffusa-l-mitigates-angiotensin-ii-induced-cardiac-hypertrophy-and-fibrosis-in-rats
#19
Prathapan A, Mathews V Varghese, Abhilash S, Salin Raj P, Anil K Mathew, Anupama Nair, R Harikumaran Nair, Raghu K G
Boerhavia diffusa is a renowned edible medicinal plant extensively used against different ailments including heart diseases in the traditional system of medicine in several countries. The present study aims to evaluate the therapeutic efficacy of ethanolic extract of Boerhavia diffusa (BDE) on cardiac hypertrophy and fibrosis induced by angiotensin II (Ang II) in male wistar rats and to identify the active components present in it. A substantial increase of hypertrophy markers such as cardiac mass index, concentration of ANP and BNP, cardiac injury markers like CK-MB, LDH and SGOT, has been observed in hypertrophied groups whereas BDE treatment attenuated these changes when compared to hypertrophied rats...
January 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28067838/effect-of-phenolic-compounds-from-elderflowers-on-glucose-and-fatty-acid-uptake-in-human-myotubes-and-hepg2-cells
#20
Giang Thanh Thi Ho, Eili Tranheim Kase, Helle Wangensteen, Hilde Barsett
Type 2 diabetes (T2D) is manifested by progressive metabolic impairments in tissues such as skeletal muscle and liver, and these tissues become less responsive to insulin, leading to hyperglycemia. In the present study, stimulation of glucose and oleic acid uptake by elderflower extracts, constituents and metabolites were tested in vitro using the HepG2 hepatocellular liver carcinoma cell line and human skeletal muscle cells. Among the crude extracts, the 96% EtOH extract showed the highest increase in glucose and oleic acid uptake in human skeletal muscle cells and HepG2-cells...
January 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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