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https://www.readbyqxmd.com/read/28346487/ml2motif-reliable-extraction-of-discriminative-sequence-motifs-from-learning-machines
#1
Marina M-C Vidovic, Marius Kloft, Klaus-Robert Müller, Nico Görnitz
High prediction accuracies are not the only objective to consider when solving problems using machine learning. Instead, particular scientific applications require some explanation of the learned prediction function. For computational biology, positional oligomer importance matrices (POIMs) have been successfully applied to explain the decision of support vector machines (SVMs) using weighted-degree (WD) kernels. To extract relevant biological motifs from POIMs, the motifPOIM method has been devised and showed promising results on real-world data...
2017: PloS One
https://www.readbyqxmd.com/read/28345812/reduced-expression-of-let-7f-activates-tgf-%C3%AE-alk5-pathway-and-leads-to-impaired-ischaemia-induced-neovascularization-after-cigarette-smoke-exposure
#2
Wahiba Dhahri, Sylvie Dussault, Paola Haddad, Julie Turgeon, Sophie Tremblay, Kevin Rolland, Michel Desjarlais, Katia Y Cáceres-Gorriti, Raphael Mathieu, Alain Rivard
This study sought to determine the potential role of microRNAs (miRNAs) in the detrimental effects of cigarette smoke on angiogenesis and neovascularization. Using large-scale miRNA profiling and qRT-PCR analyses, we identified let-7f as a pro-angiogenic miRNA which expression is significantly reduced in HUVECs treated with cigarette smoke extracts (CSE), and in the ischemic muscles of mice that are exposed to cigarette smoke (MES). In a mouse model of hindlimb ischaemia, intramuscular injection of let-7f mimic restored ischaemia-induced neovascularization in MES...
March 27, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28345745/in-vitro-and-in-vivo-assessment-of-the-abuse-potential-of-pf614-a-novel-bio-md%C3%A2-prodrug-of-oxycodone
#3
D Lynn Kirkpatrick, William K Schmidt, Ricardo Morales, John Cremin, Julie Seroogy, Craig Husfeld, Thomas Jenkins
OBJECTIVE: The need for pain medication which will not lead to abuse is well recognized. Ensysce has designed prodrug analogs of the commonly used pain medications including hydromorphone, oxycodone (OC), hydrocodone, and morphine that limit their use to oral delivery, two of which are in clinical development. This study was undertaken to demonstrate that PF614, an extended-release prodrug of OC, allows the release of OC as designed when delivered orally, yet it resists ex vivo extraction with household chemicals and is pharmacologically inactive when administered by nonoral routes (nasal and parenteral), thereby substantially reducing its intravenous (IV) and intranasal abuse potential...
January 2017: Journal of Opioid Management
https://www.readbyqxmd.com/read/28345118/effect-of-paullinia-cupana-mart-commercial-extract-during-the-aging-of-middle-age-wistar-rats-differential-effects-on-the-hippocampus-and-striatum
#4
Moara Rodrigues Mingori, Luana Heimfarth, Charles Francisco Ferreira, Henrique Mautone Gomes, Karla Suzana Moresco, Jeferson Delgado, Sabrina Roncato, Fares Zeidán-Chuliá, Daniel Pens Gelain, José Cláudio Fonseca Moreira
During aging, there is a marked decline in the antioxidant capacity of brain tissue, leading to a gradual loss of the antioxidant/oxidant balance, which causes oxidative damage. The effects of Paullinia cupana Mart. extract, which is described as being rich in caffeine and many polyphenol compounds, on the central nervous system have not been extensively investigated. The aim of this study was to therefore investigate the effect of a commercial guarana extract (CGE) on cognitive function, oxidative stress, and brain homeostasis proteins related to cognitive injury and senescence in middle age, male Wistar rats...
March 27, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28344898/the-non-recurrent-laryngeal-nerve-a-meta-analysis-and-clinical-considerations
#5
Brandon Michael Henry, Silvia Sanna, Matthew J Graves, Jens Vikse, Beatrice Sanna, Iwona M Tomaszewska, R Shane Tubbs, Jerzy A Walocha, Krzysztof A Tomaszewski
BACKGROUND: The Non-Recurrent Laryngeal Nerve (NRLN) is a rare embryologically-derived variant of the Recurrent Laryngeal Nerve (RLN). The presence of an NRLN significantly increases the risk of iatrogenic injury and operative complications. Our aim was to provide a comprehensive meta-analysis of the overall prevalence of the NRLN, its origin, and its association with an aberrant subclavian artery. METHODS: Through March 2016, a database search was performed of PubMed, CNKI, ScienceDirect, EMBASE, BIOSIS, SciELO, and Web of Science...
2017: PeerJ
https://www.readbyqxmd.com/read/28344474/biologically-guided-isolation-of-leishmanicidal-secondary-metabolites-from-euphorbia-peplus-l
#6
Elham Amin, Abeer Moawad, Hossam Hassan
Leishmaniasis is a worldwide health problem, highly endemic in developing countries. Moreover, the severe side effects and the reported drug resistance make it an urgent need to search for effective drugs that can replace or supplement those currently used. In a research program designed to investigate the antileishmanial activity of plants collected from the Egyptian flora, twenty extracts from fifteen plants growing in Egypt have been investigated for in vitro leishmanicidal activity against Leishmania donovani promastigotes...
February 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28344446/prediction-of-tennis-performance-in-junior-elite-tennis-players
#7
Tamara Kramer, Barbara C H Huijgen, Marije T Elferink-Gemser, Chris Visscher
Predicting current and future tennis performance can lead to improving the development of junior tennis players. The aim of this study is to investigate whether age, maturation, or physical fitness in junior elite tennis players in U13 can explain current and future tennis performance. The value of current tennis performance for future tennis performance is also investigated. A total of 86 junior elite tennis players (boys, n = 44; girls, n = 42) U13 (aged: 12.5 ± 0.3 years), and followed to U16, took part in this study...
March 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28343339/bound-pahs-in-sediment-and-related-environmental-significance
#8
Jian-Yang Guo, Jing-An Chen, Jing-Fu Wang, Feng-Chang Wu
Extractable polycyclic aromatic hydrocarbons (EPAHs) and bound PAHs (BPAHs) were measured in a sediment core using conventional Soxhlet extraction and a more astringent extraction method, with the objectives of determining the influence of BPAHs on the historical reconstruction of PAHs and exploring the formation of BPAHs and long-term behaviors of PAHs in sediment. The results indicated that the formation of BPAHs was clearly sediment-depth and molecular-size dependent. BPAHs represents an important portion of PAHs in sediment and cannot be extracted by conventional Soxhlet extraction...
March 25, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28343085/guava-fruit-extract-and-its-triterpene-constituents-have-osteoanabolic-effect-stimulation-of-osteoblast-differentiation-by-activation-of-mitochondrial-respiration-via-the-wnt-%C3%AE-catenin-signaling
#9
Konica Porwal, Subhashis Pal, Kapil Dev, Shyamsundar Pal China, Yogesh Kumar, Chandan Singh, Tarun Barbhuyan, Neeraj Sinha, Sabyasachi Sanyal, Arun Kumar Trivedi, Rakesh Maurya, Naibedya Chattopadhyay
The aim of this study was to evaluate the skeletal effect of guava triterpene-enriched extract (GE) in rats and identify osteogenic compounds thereof, and determine their modes of action. In growing female rats, GE at 250 mg/kg dose increased parameters of peak bone mass including femur length, bone mineral density (BMD) and biomechanical strength, suggesting that GE promoted modeling-directed bone growth. GE also stimulated bone regeneration at the site of bone injury. In adult osteopenic rats (osteopenia induced by ovariectomy, OVX) GE completely restored the lost bones at both axial and appendicular sites, suggesting a strong osteoanabolic effect...
March 8, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28343074/cratoxy-formosum-leaf-extract-inhibits-proliferation-and-migration-of-human-breast-cancer-mcf-7-cells
#10
Benjaporn Buranrat, Nootchanat Mairuae, Ampa Konsue
In this study we investigated how Cratoxy formosum (CF) leaf extract affects the viability and migration of human breast cancer cells including the mechanism(s) responsible. Our results showed that CF leaf extract strongly induced MCF-7 cell death in a concentration- and time-dependent manner, with IC50 values of 85.70±4.52μg/mL and 53.74±3.02μg/mL at 24h and 48h, respectively. Additionally, CF leaf extract potentiated the activity of 4 anticancer drugs with the greatest synergy occurring between CF and 5-FU...
March 23, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28342973/effects-of-a-sustained-release-formulation-of-1-25-dihydroxyvitamin-d3-glycosides-for-milk-fever-prevention-on-serum-1-25-dihydroxyvitamin-d3-calcium-and-phosphorus-in-dairy-cows
#11
Heinrich Bachmann, Michael Lanz, Susanne Kehrle, Wolfgang Bittner, Annick Toggenburger, Georg A Mathis, Walter Rambeck
Milk fever (MF) is a metabolic disease in dairy cows around parturition. The clinical lead sign is muscular paresis leading in severe cases to paralysis of the affected animal. Multiparturient animals of high performing dairy breeds are most likely to be affected and have a high probability of recurrence. An acute drop in blood calcium levels causes the disease when the demand for calcium at the onset of lactation exceeds the ability to replete blood calcium levels through mobilization from bone and intestinal uptake...
March 22, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28342628/poor-sleep-quality-depression-and-hope-before-breast-cancer-surgery
#12
Thalyta Cristina Mansano-Schlosser, Maria Filomena Ceolim, Teresa D Valerio
AIM: This study aims to identify the predictors of poor sleep quality and the associations between depression, hope and sleep in a sample of 156 women with breast cancer prior to surgery. BACKGROUND: The care and treatment of breast cancer is among the most important scientific challenges in public health. Sleep disturbances and depression are the important complaint of cancer patients. However, they are often neglected. Patients diagnosed with breast cancer also experience prejudice, fear of death, suffering, mutilation, fear of lymphedema, as well as feelings of social devaluation leading to hopelessness Several studies point to hope as an effective strategy to help patients cope with difficulties and achieve their goals, especially patients with cancer...
April 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28342004/modulatory-effects-of-terminalia-arjuna-against-domoic-acid-induced-toxicity-in-caco-2-cell-line
#13
E M Ramya, G Phani Kumar, T Anand, K R Anilakumar
Domoic acid is a potent marine algal toxin produced by diatomic genus of Pseudo-nitzschia causing amnesic shell fish poisoning. Domoic acid toxicosis mainly involves excitotoxic effects coupled with oxidative stress. The present study was aimed to evaluate the protective effects of hydro-alcoholic extract of Terminalia arjuna (TA) against domoic acid induced toxic effects in Caco-2 cell line. It was observed that the toxicity induced by domoic acid in Caco-2 cells was mediated by oxidative insult leading to morphological changes, DNA damage and apoptosis...
March 24, 2017: Cytotechnology
https://www.readbyqxmd.com/read/28341970/impact-of-dyspnea-on-advanced-cancer-patients-referred-to-a-palliative-radiotherapy-clinic
#14
Leigha Rowbottom, Stephanie Chan, Liying Zhang, Rachel McDonald, Elizabeth Barnes, May Tsao, Pearl Zaki, Edward Chow
PURPOSE: Dyspnea is a debilitating symptom commonly experienced by advanced cancer patients that can lead to negative effects on function and quality of life (QOL). The present study aims to determine the relationship between dyspnea and other Edmonton Symptom Assessment System (ESAS) symptoms in palliative cancer patients referred to a radiotherapy clinic. METHODS: The presence and severity of dyspnea was measured using the ESAS. All patients that visited a palliative radiotherapy clinic between 1999 to 2002 and 2006 to 2009 and completed the ESAS were included...
March 24, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28341817/impairment-of-macrophage-presenting-ability-and-viability-by-echinococcus-granulosus-antigens
#15
Naceur Mejri, Imed Eddine Hassen, Jenny Knapp, Mouldi Saidi
BACKGROUND: Despite advances toward an improved understanding of the evasive mechanisms leading to the establishment of cystic echinococcosis, the discovery of specific immunosuppressive mechanisms and related factors are of great interest in the development of an immunotherapeutic approach. OBJECTIVE: To elucidate immunosuppressive effects of bioactive factors contained in chromatographic fractions from hydatid cystic fluid (HCF) of Echinococcus granulosus. METHODS: Hydatid cystic fluid was fractionated by reverse phase chromatography...
March 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28341632/microvascular-leakage-in-acute-myocardial-infarction-characterization-by-histology-biochemistry-and-magnetic-resonance-imaging
#16
Xiao-Ming Gao, Qi-Zhu Wu, Helen Kiriazis, Yidan Su, Li-Ping Han, James Pearson, Andrew Taylor, Xiao-Jun Du
Cardiac microvascular obstruction (MVO) following ischemia/reperfusion (I/R) has been well studied, but microvascular leakage (MVL) remains largely unexplored. We characterized MVL in the mouse I/R model by histology, biochemistry and cardiac magnetic resonance (CMR) imaging. I/R was induced surgically in mice. MVL was determined by administrating microvascular permeability tracer Evans blue (EB) and/or gadolinium-DTPA contrast. The size of MVL, infarction and MVO in the heart was quantified histologically...
March 24, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28340768/sio2-coated-magnetic-graphene-oxide-modified-with-polypyrrole-polythiophene-a-novel-and-efficient-nanocomposite-for-solid-phase-extraction-of-trace-amounts-of-heavy-metals
#17
Karam Molaei, Hasan Bagheri, Ali Akbar Asgharinezhad, Homeira Ebrahimzadeh, Mojtaba Shamsipur
The synthesis of a novel nanocomposite comprised of SiO2-coated magnetic graphene oxide modified with a pyrrole-thiophene (mGO/SiO2@coPPy-Th) copolymer is reported in the present work. The nanocomposite was applied for the fast magnetic solid phase extraction (MSPE) of trace levels of copper, lead, chromium, zinc and cadmium from water and agricultural samples. The nanocomposite was prepared in three steps: (1) decoration of graphene oxide sheets with magnetite nanoparticles thorough a facile one-step chemical reaction strategy; (2) chemical grafting by a silica layer to obtain high stability in acidic solutions; and (3) surface modification by coPPy-Th via simultaneous oxidation polymerization of pyrrole and thiophene in the presence of mGO/SiO2 composite...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28340622/anti-plasmodial-activity-of-norcaesalpin-d-and-extracts-of-four-medicinal-plants-used-traditionally-for-treatment-of-malaria
#18
Ramadhani Selemani Omari Nondo, Mainen Julius Moshi, Paul Erasto, Pax Jessey Masimba, Francis Machumi, Abdul Waziri Kidukuli, Matthias Heydenreich, Denis Zofou
BACKGROUND: Malaria is an old life-threatening parasitic disease that is still affecting many people, mainly children living in sub-Saharan Africa. Availability of effective antimalarial drugs played a significant role in the treatment and control of malaria. However, recent information on the emergence of P. falciparum parasites resistant to one of the artemisinin-based combination therapies suggests the need for discovery of new drug molecules. Therefore, this study aimed to evaluate the antiplasmodial activity of extracts, fractions and isolated compound from medicinal plants traditionally used in the treatment of malaria in Tanzania...
March 24, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28340607/randomised-double-blind-placebo-controlled-trials-of-non-individualised-homeopathic-treatment-systematic-review-and-meta-analysis
#19
Robert T Mathie, Nitish Ramparsad, Lynn A Legg, Jürgen Clausen, Sian Moss, Jonathan R T Davidson, Claudia-Martina Messow, Alex McConnachie
BACKGROUND: A rigorous systematic review and meta-analysis focused on randomised controlled trials (RCTs) of non-individualised homeopathic treatment has not previously been reported. We tested the null hypothesis that the main outcome of treatment using a non-individualised (standardised) homeopathic medicine is indistinguishable from that of placebo. An additional aim was to quantify any condition-specific effects of non-individualised homeopathic treatment. METHODS: Literature search strategy, data extraction and statistical analysis all followed the methods described in a pre-published protocol...
March 24, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28340289/remote-ischaemic-conditioning-decreases-blood-flow-and-improves-oxygen-extraction-in-patients-with-early-complex-regional-pain-syndrome
#20
T Hegelmaier, N Kumowski, T Mainka, J Vollert, O Goertz, M Lehnhardt, P K Zahn, C Maier, J Kolbenschlag
BACKGROUND: Remote ischaemic conditioning (RIC) is the cyclic application of non-damaging ischaemia leading to an increased tissue perfusion, among others triggered by NO (monoxide). Complex regional pain syndrome (CRPS) is known to have vascular alterations such as increased blood shunting and decreased NO blood-levels, which in turn lead to decreased tissue perfusion. We therefore hypothesized that RIC could improve tissue perfusion in CRPS. METHOD: In this proof-of-concept study, RIC was applied in the following groups: in 21 patients with early CRPS with a clinical history less than a year, in 20 age/sex-matched controls and in 12 patients with unilateral nerve lesions via a tourniquet on the unaffected/non-dominant upper limb...
March 24, 2017: European Journal of Pain: EJP
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