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https://www.readbyqxmd.com/read/29036902/dna-adducts-formed-by-aristolochic-acid-are-unique-biomarkers-of-exposure-and-explain-the-initiation-phase-of-upper-urothelial-cancer
#1
REVIEW
Marie Stiborová, Volker M Arlt, Heinz H Schmeiser
Aristolochic acid (AA) is a plant alkaloid that causes aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN), unique renal diseases frequently associated with upper urothelial cancer (UUC). This review summarizes the significance of AA-derived DNA adducts in the aetiology of UUC leading to specific A:T to T:A transversion mutations (mutational signature) in AAN/BEN-associated tumours, which are otherwise rare in individuals with UCC not exposed to AA. Therefore, such DNA damage produced by AA-DNA adducts is one rare example of the direct association of exposure and cancer development (UUC) in humans, confirming that the covalent binding of carcinogens to DNA is causally related to tumourigenesis...
October 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29036870/development-and-validation-of-a-new-safety-climate-scale-for-petrochemical-industries
#2
Mohammad Javad Jafari, Davood Eskandari, Firouz Valipour, Yadollah Mehrabi, Hossein Charkhand, Mostafa Mirghotbi
BACKGROUND: While a considerable body of research has studied safety climate and its role as a leading indicator of organizational safety, much of this work has been conducted with Western manufacturing samples. OBJECTIVE: The current study puts emphasis on the cross-validation of a safety climate model in the non-Western industrial context of Iranian petrochemical industries. METHODS: The current study was performed in one petrochemical company in Iran...
October 8, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29036069/human-detection-in-occluded-scenes-through-optically-inspired-multi-camera-image-fusion
#3
Maryam Ghaneizad, Zahra Kavehvash, Hamid Aghajan
In this paper, a novel approach for foreground extraction has been proposed based on a popular three-dimensional imaging technique in optics, called integral imaging. In this approach, multiple viewpoint images captured from a three-dimensional scene are used to extract range information of the scene and effectively extract an object or a person, even in the presence of heavy occlusion. The algorithm consists of two parts: depth estimation and reconstruction of the targeted object at the estimated depth distance...
June 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29035965/effectiveness-of-bedrails-in-preventing-falls-among-hospitalized-older-adults-a-systematic-review
#4
Paulo Marques, Carmen Queirós, João Apóstolo, Daniela Cardoso
BACKGROUND: Falls are a major problem today affecting adults of any age, but the elderly are a population that is more susceptible to falls. Falls are the leading cause of injury or death among older adults. Hospitalized older people are particularly vulnerable to falls. Falls cause direct injuries (minor injuries, severe wounds of the soft tissues and bone fractures) to patients and increased length of stay. The prevention of falls is commonly considered an indicator of the quality of care...
October 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29035787/identification-of-n-linked-glycosylation-sites-in-the-spike-protein-and-their-functional-impact-on-the-replication-and-infectivity-of-coronavirus-infectious-bronchitis-virus-in-cell-culture
#5
Jie Zheng, Yoshiyuki Yamada, To Sing Fung, Mei Huang, Raymond Chia, Ding Xiang Liu
Spike (S) glycoprotein on the viral envelope is the main determinant of infectivity. The S protein of coronavirus infectious bronchitis virus (IBV) contains 29 putative asparagine(N)-linked glycosylation sites. These post-translational modifications may assist in protein folding and play important roles in the functionality of S protein. In this study, we used bioinformatics tools to predict N-linked glycosylation sites and to analyze their distribution in IBV strains and variants. Among these sites, 8 sites were confirmed in the S protein extracted from partially purified virus particles by proteomics approaches...
October 13, 2017: Virology
https://www.readbyqxmd.com/read/29035036/nanoprobe-synthesized-by-magnetotactic-bacteria-detecting-fluorescence-variations-under-dissociation-of-rhodamine-b-from-magnetosomes-following-temperature-ph-changes-or-the-application-of-radiation
#6
Edouard Alphandéry, Darine Abi Haidar, Olivier Seksek, Maxime Thoreau, Alain Trautmann, Nadege Bercovici, Florence Gazeau, François Guyot, Imène Chebbi
We report a method of fabrication of fluorescent magnetosomes, designated as MCR400, in which 400 μM of rhodamine B are introduced in the growth medium of AMB-1 magnetotactic bacteria and fluorescent magnetosomes are then extracted from these bacteria. These fluorescent magnetosomes behave differently from most fluorescent nanoprobes, which often lead to fluorescence losses over time due to photobleaching. Indeed, when MCR400 are heated to 30-90 °C, brought to an acidic pH, or exposed to radiations, we observed that their fluorescence intensity increased...
October 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29034405/immunohistochemical-and-serological-characterization-of-membranous-nephropathy-in-children-and-adolescents
#7
Anne K Dettmar, Thorsten Wiech, Markus J Kemper, Armin Soave, Michael Rink, Jun Oh, Rolf A K Stahl, Elion Hoxha
BACKGROUND: Membranous nephropathy (MN) is a common cause of nephrotic syndrome in adults, but is less frequent in children. Antibodies against four antigens leading to MN have been described in children: phospholipase A2 receptor 1 (PLA2R1), thrombospondin type-1 domain-containing 7A (THSD7A), neutral endopeptidase (NEP), and cationic bovine serum albumin (BSA). METHODS: Twelve children with MN were included in this study. Sera of all patients were analyzed for antibodies against PLA2R1, THSD7A, NEP, and BSA...
October 15, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29034188/validation-of-therapeutic-anti-inflammatory-potential-of-arjuna-ksheera-paka-a-traditional-ayurvedic-formulation-of-terminalia-arjuna
#8
Nivedita Dube, Chetan Nimgulkar, Dinesh Kumar Bharatraj
Arjuna Ksheera Paka (AKP), a traditional Ayurvedic formulation of Terminalia arjuna (T. arjuna) bark powder is used for its cardioprotective effects. However, its anti-inflammatory efficacy remained unexplored. In the present study, AKP was prepared in cow milk (as per standard Ayurvedic procedure) and compared with standard hydroalcoholic extract (HA) of T. arjuna. The extracts were analyzed for gross phytoconstituents levels, and their antioxidant activity was assayed by DPPH free radical scavenging activity and inhibition of lipid peroxidation...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29033904/an-improved-in-house-maldi-tof-ms-protocol-for-direct-cost-effective-identification-of-pathogens-from-blood-cultures
#9
Menglan Zhou, Qiwen Yang, Timothy Kudinha, Liying Sun, Rui Zhang, Chang Liu, Shuying Yu, Meng Xiao, Fanrong Kong, Yupei Zhao, Ying-Chun Xu
Background: Bloodstream infection is a major cause of morbidity and mortality in hospitalized patients worldwide. Delays in the identification of microorganisms often leads to a poor prognosis. The application of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) directly to blood culture (BC) broth can potentially identify bloodstream infections earlier, and facilitate timely management. Methods: We developed an "in-house" (IH) protocol for direct MALDI-TOF MS based identification of organisms in positive BCs...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29033546/safety-and-efficacy-profile-of-pembrolizumab-in-solid-cancer-pooled-reanalysis-based-on-randomized-controlled-trials
#10
Manni Wang, Xuelei Ma, Linghong Guo, Fan Xia
BACKGROUND: The aim of the present review is to systematically evaluate the efficacy and safety of pembrolizumab by analyzing survival outcomes and at the same time, to present evidence for future clinical applications of anti-programmed cell death protein 1 (anti-PD-1) antibodies by analyzing the efficacy and safety of pembrolizumab. METHODS: A comprehensive literature search of PubMed, Medline, and Embase was performed for all relevant clinical trials. In this study, adverse events of any grades and grades ≥3 were summarized and calculated for event rates...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29033518/a-rare-experience-of-infective-residual-sheath-in-the-wall-of-the-innominate-vein-after-extraction-of-implantable-defibrillators
#11
Yuan-Hao Liu, Wei-Shiang Lin, Yi-Chang Lin, Chih-Yuan Lin, Chien-Sung Tsai, Yi-Ting Tsai
BACKGROUND: Cardiac device-related infective endocarditis is an uncommon but potentially fatal complication. Therefore, cardiac devices should be removed as soon as a device-related infection is suspected. CASE REPORT: A 56-year-old male with a history of arrhythmogenic right ventricular dysplasia with implantable cardioverter-defibrillators (ICDs) 7 years earlier and re-implantation of ICDs due to dysfunction 18 months ago presented with erosion of the ICD pocket with Pseudomonas bacteremia...
July 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29033009/lead-extraction-aspects-beyond-the-procedure
#12
EDITORIAL
Patrizio Mazzone, Andrea Radinovic
No abstract text is available yet for this article.
September 13, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29032885/the-subtle-connection-between-development-of-cardiac-implantable-electrical-device-infection-and-survival-after-complete-system-removal-an-observational-prospective-multicenter-study
#13
Igor Diemberger, Federico Migliore, Mauro Biffi, Alberto Cipriani, Emanuele Bertaglia, Stefano Lorenzetti, Giulia Massaro, Gaia Tanzarella, Giuseppe Boriani
BACKGROUND: Despite the improvements in transvenous lead extraction (TLE), patients with cardiac implantable device related infection (CIEDI) have a poor prognosis at long term. We explored the possible role of factors associated with development of CIEDI as predictors of post-TLE survival. METHODS: We performed a multi-center prospective observational study in a population of consecutive patients referred for TLE for CIEDI. We adopted a previously developed 10-point scale for CIEDI risk stratification and assessed its performance in predicting post-TLE survival...
October 9, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29032071/comparing-intestinal-versus-diffuse-gastric-cancer-using-a-peff-oriented-proteomic-pipeline
#14
Helisa Helena Wippel, Marlon Dias Mariano Santos, Milan Avila Clasen, Louise Ulrich Kurt, Fabio Cesar Sousa Nogueira, Carlos Eduardo Carvalho, Thaís Messias McCormick, Guilherme Pinto Bravo Neto, Lysangela Ronalte Alves, Maria da Gloria da Costa Carvalho, Paulo Costa Carvalho, Juliana de Saldanha da Gama Fischer
Gastric cancer is the fifth most common malignant neoplasia and the third leading cause of cancer death worldwide. Mac-Cormick et al. recently showed the importance of considering the anatomical region of the tumor in proteomic gastric cancer studies; more differences were found between distinct anatomical regions than when comparing healthy versus diseased tissue. Thus, failing to consider the anatomical region could lead to differential proteins that are not disease specific. With this as motivation, we compared the proteomic profiles of intestinal and diffuse adenocarcinoma from the same anatomical region, the corpus...
October 11, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/29032047/reactivation-of-peroxidase-activity-in-human-saliva-samples-by-polyphenols
#15
Jana Gau, Jürgen Arnhold, Jörg Flemmig
OBJECTIVES: The enzyme lactoperoxidase (LPO), which is released into several body fluids like saliva, is an essential part to maintain the oral bacterial homeostasis by catalysing the oxidation of thiocyanate (SCN(-)) to hypo-thiocyanite ((-)OSCN). The formation of unreactive redox intermediates (like Compound II) leads to a decreased pseudo-halogenating enzyme activity, which is associated with a higher risk for oral infections. According to former studies with bovine LPO selected flavonoids were tested in respect to their potential to reactivate the enzymatic activity in a more physiological, human salivary system...
October 7, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29031887/direct-colorimetric-detection-of-unamplified-pathogen-dna-by-dextrin-capped-gold-nanoparticles
#16
Amy M Baetsen-Young, Matthew Vasher, Leann L Matta, Phil Colgan, Evangelyn C Alocilja, Brad Day
The interaction between gold nanoparticles (AuNPs) and nucleic acids has facilitated a variety of diagnostic applications, with further diversification of synthesis match bio-applications while reducing biotoxicity. However, DNA interactions with unique surface capping agents have not been fully defined. Using dextrin-capped AuNPs (d-AuNPs), we have developed a novel unamplified genomic DNA (gDNA) nanosensor, exploiting dispersion and aggregation characteristics of d-AuNPs, in the presence of gDNA, for sequence-specific detection...
October 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29031765/an-increased-autophagic-flux-contributes-to-the-anti-inflammatory-potential-of-urolithin-a-in-macrophages
#17
Yaw Duah Boakye, Laura Groyer, Elke H Heiss
BACKGROUND: An extract of Phyllanthus muellerianus and its constituent geraniin have been reported to exert anti-inflammatory activity in vivo. However, orally consumed geraniin, an ellagitannin, shows low bioavailability and undergoes metabolization to urolithins by gut microbiota. This study aimed at comparing geraniin and urolithin A with respect to inhibition of M1 (LPS) polarization of murine J774.1 macrophages and shedding more light on possible underlying mechanisms. METHODS: Photometric, fluorimetric as well as luminescence-based assays monitored production of reactive oxygen species (ROS) and nitric oxide (NO), cell viability or reporter gene expression...
October 11, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29030668/desktop-nmr-spectroscopy-for-real-time-monitoring-of-an-acetalization-reaction-in-comparison-with-gas-chromatography-and-nmr-at-9-4%C3%A2-t
#18
Kawarpal Singh, Ernesto Danieli, Bernhard Blümich
Monitoring of chemical reactions in real-time is in demand for process control. Different methods such as gas chromatography (GC), mass spectroscopy, infrared spectroscopy, and nuclear magnetic resonance (NMR) are used for that purpose. The current state-of-the-art compact NMR systems provide a useful method to employ with various reaction conditions for studying chemical reactions inside the fume hood at the chemical workplace. In the present study, an acetalization reaction was investigated with compact NMR spectroscopy in real-time...
October 13, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29030144/regulation-of-the-membrane-structure-by-brassinosteroids-and-progesterone-in-winter-wheat-seedlings-exposed-to-low-temperature
#19
Maria Filek, Elżbieta Rudolphi-Skórska, Apolonia Sieprawska, Miroslav Kvasnica, Anna Janeczko
Steroids constitute one of the most important groups of compounds of regulatory properties both in the animal and plant kingdom. In plants, steroids such as brassinosteroids or progesterone, by binding to protein receptors in cell membranes, regulate growth and initiate processes leading to increased tolerance to stress conditions. Due to their structural similarities to sterols, these steroids may also directly interact with cellular membranes. Our aim was to determine the changes of the structural parameters of lipid membranes under the influence of hydrophobic steroid compounds, i...
October 10, 2017: Steroids
https://www.readbyqxmd.com/read/29029712/advanced-cardiopulmonary-support-for-pulmonary-embolism
#20
Oren Friedman, James M Horowitz, Danny Ramzy
Management of high-risk pulmonary embolism (PE) requires an understanding of the pathophysiology of PE, options for rapid clot reduction, critical care interventions, and advanced cardiopulmonary support. PE can lead to rapid respiratory and hemodynamic collapse via a complex sequence of events leading to acute right ventricular failure. Importantly, reduction in pulmonary vascular resistance must be accomplished either by systemic thrombolytics, catheter directed thrombolytics, endovascular clot extraction, or surgical embolectomy...
September 2017: Techniques in Vascular and Interventional Radiology
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