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https://www.readbyqxmd.com/read/29673354/clinical-workplace-learning-perceived-learning-value-of-individual-and-group-feedback-in-a-collectivistic-culture
#1
Yoyo Suhoyo, Johanna Schönrock-Adema, Ova Emilia, Jan B M Kuks, Janke Cohen-Schotanus
BACKGROUND: Feedback is essential for workplace learning. Most papers in this field concern individual feedback. In collectivistic cultures, however, group feedback is common educational practice. This study was conducted to investigate the perceived learning value and characteristics of individual and group feedback in a collectivistic culture. METHODS: During two weeks, on a daily basis, clerkship students (n = 215) from 12 clinical departments at Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia, recorded individual and group feedback moments by using a structured form: the providers, focus and perceived learning value of feedback...
April 19, 2018: BMC Medical Education
https://www.readbyqxmd.com/read/29657864/a-sequence-dependent-dna-condensation-induced-by-prion-protein
#2
Alakesh Bera, Sajal Biring
Different studies indicated that the prion protein induces hybridization of complementary DNA strands. Cell culture studies showed that the scrapie isoform of prion protein remained bound with the chromosome. In present work, we used an oxazole dye, YOYO, as a reporter to quantitative characterization of the DNA condensation by prion protein. We observe that the prion protein induces greater fluorescence quenching of YOYO intercalated in DNA containing only GC bases compared to the DNA containing four bases whereas the effect of dye bound to DNA containing only AT bases is marginal...
2018: Journal of Nucleic Acids
https://www.readbyqxmd.com/read/29605400/extracellular-dna-promotes-colorectal-tumor-cell-survival-after-cytotoxic-chemotherapy
#3
Reginald Anunobi, Brian A Boone, Nick Cheh, Daolin Tang, Rui Kang, Tara Loux, Michael T Lotze, Herbert J Zeh
BACKGROUND: Inflammation promotes the growth and survival of malignant cells. Inflammation within the tumor microenvironment is a result of damage-associated molecular patterns released by dead or dying cells that provide survival signals to the surrounding cells. It has been proposed that extracellular DNA can act as a damage-associated molecular pattern given the association between circulating DNA and autoimmune diseases. Herein, we demonstrate a novel role for genomic extracellular DNA binding to the Toll-like receptor (TLR)-9 on tumor cells in response to cytotoxic insult...
March 28, 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29604805/a-polarized-view-on-dna-under-tension
#4
Joost van Mameren, Karen Vermeulen, Gijs J L Wuite, Erwin J G Peterman
In the past decades, sensitive fluorescence microscopy techniques have contributed significantly to our understanding of the dynamics of DNA. The specific labeling of DNA using intercalating dyes has allowed for quantitative measurement of the thermal fluctuations the polymers undergo. On the other hand, recent advances in single-molecule manipulation techniques have unraveled the mechanical and elastic properties of this intricate polymer. Here, we have combined these two approaches to study the conformational dynamics of DNA under a wide range of tensions...
March 28, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29601063/correction-photobleaching-of-yoyo-1-in-super-resolution-single-dna-fluorescence-imaging
#5
Joseph R Pyle, Jixin Chen
[This corrects the article DOI: 10.3762/bjnano.8.229.].
2018: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/29501972/reactive-balance-performance-and-neuromuscular-and-cognitive-responses-to-unpredictable-balance-perturbations-in-children-with-developmental-coordination-disorder
#6
Yoyo T Y Cheng, William W N Tsang, Catherine Mary Schooling, Shirley S M Fong
Developmental coordination disorder (DCD) is a common motor disorder affecting balance performance. However, few studies have investigated reactive balance performance and the underlying mechanisms in children with DCD. This study aimed to compare the reactive balance performance, lower limb muscle reflex contraction latency and attention level in response to unpredictable balance perturbations between 100 typically developing children and 120 children with DCD (with and without comorbid autism spectrum disorder) aged 6-9 years...
March 1, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29439488/a-physical-health-profile-of-youths-living-with-a-hikikomori-lifestyle
#7
John W M Yuen, Yoyo K Y Yan, Victor C W Wong, Wilson W S Tam, Ka-Wing So, Wai-Tong Chien
A cross-sectional study was designed to understand the impacts of "hikikomori" lifestyle on physical health. A total of 104 eligible hikikomori cases were recruited from the social services network of Hong Kong with a mean age of 19.02 ± 3.62 (ranged 13-31) year-old, and had completed the set of questionnaires and a series of anthropometric and physical health measurements. Despite SF36 score of 84.0 indicated good physical functioning in general, participants were lived sedentarily with high incidence of hypertension at 15...
February 11, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29402968/integrating-functional-analysis-in-the-next-generation-sequencing-diagnostic-pipeline-of-rasopathies
#8
Gordon K C Leung, H M Luk, Vincent H M Tang, W W Gao, Christopher C Y Mak, Mullin H C Yu, W L Wong, Yoyo W Y Chu, W L Yang, Wilfred H S Wong, Alvin C H Ma, Anskar Y H Leung, D Y Jin, Kelvin Y K Chan, Judith Allanson, Ivan F M Lo, Brian H Y Chung
RASopathies are a group of heterogeneous conditions caused by germline mutations in RAS/MAPK signalling pathway genes. With next-generation sequencing (NGS), sequencing capacity is no longer a limitation to molecular diagnosis. Instead, the rising number of variants of unknown significance (VUSs) poses challenges to clinical interpretation and genetic counselling. We investigated the potential of an integrated pipeline combining NGS and the functional assessment of variants for the diagnosis of RASopathies...
February 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29204325/acute-ischemic-preconditioning-does-not-influence-high-intensity-intermittent-exercise-performance
#9
Isabela Coelho Marocolo, Gustavo Ribeiro da Mota, André Monteiro Londe, Stephen D Patterson, Octávio Barbosa Neto, Moacir Marocolo
This study evaluated the acute effect of ischemic preconditioning (IPC) on a high-intensity intermittent exercise performance and physiological indicators in amateur soccer players. Thirteen players (21.5 ± 2 yrs) attended three trials separated by 3-5 days in a counterbalanced randomized cross-over design: IPC (4 × 5-min occlusion 220 mmHg/reperfusion 0 mmHg) in each thigh; SHAM (similar to the IPC protocol but "occlusion" at 20 mmHg) and control (seated during the same time of IPC). After 6-min of each trial (IPC, SHAM or control), the players performed the YoYo Intermittent Endurance Test level 2 (YoYoIE2)...
2017: PeerJ
https://www.readbyqxmd.com/read/29191498/a-report-of-three-families-with-fbn1-related-acromelic-dysplasias-and-review-of-literature-for-genotype-phenotype-correlation-in-geleophysic-dysplasia
#10
S W Cheng, Ho-Ming Luk, YoYo W Y Chu, Yuet-Ling Tung, Elanie Yin-Wah Kwan, Ivan Fai-Man Lo, Brian Hon-Yin Chung
Acromelic dysplasia is a heterogeneous group of rare skeletal dysplasias characterized by distal limb shortening. Weill-Marchesani syndrome (WMS), Geleophysic dysplasia (GD) and Acromicric dysplasia (AD) are clinically distinct entities within this group of disorders and are characterized by short stature, short hands, stiff joints, skin thickening, facial anomalies, normal intelligence and skeletal abnormalities. Mutations of the Fibrillin-1 (FBN1) gene have been reported to cause AD, GD and related phenotypes...
November 27, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29181286/photobleaching-of-yoyo-1-in-super-resolution-single-dna-fluorescence-imaging
#11
Joseph R Pyle, Jixin Chen
Super-resolution imaging of single DNA molecules via point accumulation for imaging in nanoscale topography (PAINT) has great potential to visualize fine DNA structures with nanometer resolution. In a typical PAINT video acquisition, dye molecules (YOYO-1) in solution sparsely bind to the target surfaces (DNA) whose locations can be mathematically determined by fitting their fluorescent point spread function. Many YOYO-1 molecules intercalate into DNA and remain there during imaging, and most of them have to be temporarily or permanently fluorescently bleached, often stochastically, to allow for the visualization of a few fluorescent events per DNA per frame of the video...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28944722/is-strength-training-frequency-a-key-factor-to-develop-performance-adaptations-in-young-elite-soccer-players
#12
Carlos Otero-Esquina, Moisés de Hoyo Lora, Óliver Gonzalo-Skok, Sergio Domínguez-Cobo, Hugo Sánchez
The aim of this study was to analyse the effects of a combined strength-training programme (full-back squat, YoYo(TM) leg curl, plyometrics and sled towing exercises) on performance in elite young soccer players and to examine the effects when this training programme was performed one or two days per week. Thirty-six male soccer players (U-17 to U-19) were recruited and assigned to experimental groups (EXP1: 1 s w(-1); EXP2: 2 s w(-1)) or a control group (CON). Performance was assessed through a countermovement jump (CMJ) test (relative peak power [CMJPP] and CMJ height [CMJH]), a 20-m linear sprint test with split-times at 10-m, and a change of direction test (V-cut test) 1 week before starting the training programme and also 1 week after performing such training programme...
November 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28857114/the-statistical-segment-length-of-dna-opportunities-for-biomechanical-modeling-in-polymer-physics-and-next-generation-genomics
#13
Kevin D Dorfman
The development of bright bisintercalating dyes for deoxyribonucleic acid (DNA) in the 1990s, most notably YOYO-1, revolutionized the field of polymer physics in the ensuing years. These dyes, in conjunction with modern molecular biology techniques, permit the facile observation of polymer dynamics via fluorescence microscopy and thus direct tests of different theories of polymer dynamics. At the same time, they have played a key role in advancing an emerging next-generation method known as genome mapping in nanochannels...
February 1, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28833068/pervasive-gene-expression-responses-to-a-fluctuating-diet-in-drosophila-melanogaster-the-importance-of-measuring-multiple-traits-to-decouple-potential-mediators-of-life-span-and-reproduction
#14
Jelle Zandveld, Joost van den Heuvel, Maarten Mulder, Paul M Brakefield, Thomas B L Kirkwood, Daryl P Shanley, Bas J Zwaan
Phenotypic plasticity is an important concept in life-history evolution, and most organisms, including Drosophila melanogaster, show a plastic life-history response to diet. However, little is known about how these life-history responses are mediated. In this study, we compared adult female flies fed an alternating diet (yoyo flies) with flies fed a constant low (CL) or high (CH) diet and tested how whole genome expression was affected by these diet regimes and how the transcriptional responses related to different life-history traits...
November 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/28730897/intervention-and-management-of-developmental-coordination-disorder-are-we-providing-evidence-based-services-intervention-et-traitement-d-un-trouble-du-d%C3%A3-veloppement-de-la-coordination-les-ergoth%C3%A3-rapeutes-fournissent-ils-des-services-fond%C3%A3-s-sur-les-faits
#15
Renée Withers, Yoyo Tsang, Jill G Zwicker
BACKGROUND: Occupational therapists are well positioned to provide intervention to improve outcomes for children with developmental coordination disorder. However, little is known about what occupational therapy services are provided for these children. PURPOSE: As part of a larger study exploring service provision for children with developmental coordination disorder, the purpose of this study was to examine intervention and referral practices of occupational therapists in British Columbia, Canada...
June 2017: Canadian Journal of Occupational Therapy. Revue Canadienne D'ergothérapie
https://www.readbyqxmd.com/read/28699126/a-report-on-ten-asia-pacific-countries-on-current-status-and-future-directions-of-the-genetic-counseling-profession-the-establishment-of-the-professional-society-of-genetic-counselors-in-asia
#16
Mercy Y Laurino, Kathleen A Leppig, Peter James Abad, Breana Cham, Yoyo Wing Yiu Chu, Saahil Kejriwal, Juliana M H Lee, Darci L Sternen, Jennifer K Thompson, Matthew J Burgess, Shu Chien, Niby Elackatt, Jiin Ying Lim, Thanyachai Sura, Sultana Faradz, Carmencita Padilla, Eva Cutiongco de-la Paz, Donny Nauphar, Khanh Ngoc Nguyen, Olya Zayts, Dung Chi Vu, Meow-Keong Thong
The Professional Society of Genetic Counselors in Asia (PSGCA) was recently established as a special interest group of the Asia Pacific Society of Human Genetics. Fostering partnerships across the globe, the PSGCA's vision is to be the lead organization that advances and mainstreams the genetic counseling profession in Asia and ensures individuals have access to genetic counseling services. Its mission is to promote quality genetic counseling services in the region by enhancing practice and curricular standards, research and continuing education...
July 11, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/28670437/use-of-clinical-chromosomal-microarray-in-chinese-patients-with-autism-spectrum-disorder-implications-of-a-copy-number-variation-involving-dpp10
#17
Annisa Shui Lam Mak, Annie Ting Gee Chiu, Gordon Ka Chun Leung, Christopher Chun Yu Mak, Yoyo Wing Yiu Chu, Gary Tsz Kin Mok, Wing Fai Tang, Kelvin Yuen Kwong Chan, Mary Hoi Yin Tang, Elizabeth Tak-Kwong Lau Yim, Kin Wai So, Victoria Qinchen Tao, Cheuk Wing Fung, Virginia Chun Nei Wong, Mohammed Uddin, So Lun Lee, Christian R Marshall, Stephen W Scherer, Anita Sik Yau Kan, Brian Hon Yin Chung
BACKGROUND: Array comparative genomic hybridization (aCGH) is recommended as a first-tier genetic test for children with autism spectrum disorder (ASD). However, interpretation of results can often be challenging partly due to the fact that copy number variants (CNVs) in non-European ASD patients are not well studied. To address this literature gap, we report the CNV findings in a cohort of Chinese children with ASD. METHODS: DNA samples were obtained from 258 Chinese ASD patients recruited from a child assessment center between January 2011 and August 2014...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28658073/monitoring-changes-in-power-speed-agility-and-endurance-in-elite-cricketers-during-the-off-season
#18
Chris Bishop, Ross Herridge, Anthony Turner
The purpose of this study was to monitor changes in power, speed, agility and endurance in elite cricketers during the 20-week off-season period. Fourteen elite male cricketers (age 26.2 ± 5.3years; height 180.8 ± 8.5cm; mass 83.5 ± 6.7kg) conducted a physical testing battery in week 1 and week 18 of the off-season period. The testing included a yoyo intermittent recovery test (yoyo IRT), bilateral and unilateral countermovement jumps (CMJ), squat jump (SJ), broad jump (BJ), drop jump (to calculate reactive strength index - [RSI]), pro agility and 5, 10, 20m sprint tests...
June 22, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28575650/defects-in-the-cell-signaling-mediator-%C3%AE-catenin-cause-the-retinal-vascular-condition-fevr
#19
Evangelia S Panagiotou, Carla Sanjurjo Soriano, James A Poulter, Emma C Lord, Denisa Dzulova, Hiroyuki Kondo, Atsushi Hiyoshi, Brian Hon-Yin Chung, Yoyo Wing-Yiu Chu, Connie H Y Lai, Mark E Tafoya, Dyah Karjosukarso, Rob W J Collin, Joanne Topping, Louise M Downey, Manir Ali, Chris F Inglehearn, Carmel Toomes
Familial exudative vitreoretinopathy (FEVR) is an inherited blinding disorder characterized by the abnormal development of the retinal vasculature. The majority of mutations identified in FEVR are found within four genes that encode the receptor complex (FZD4, LRP5, and TSPAN12) and ligand (NDP) of a molecular pathway that controls angiogenesis, the Norrin-β-catenin signaling pathway. However, half of all FEVR-affected case subjects do not harbor mutations in these genes, indicating that further mutated genes remain to be identified...
June 1, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28529709/last-rolls-of-the-yoyo-assessing-the-human-canonical-protein-count
#20
REVIEW
Christopher Southan
In 2004, when the protein estimate from the finished human genome was only 24,000, the surprise was compounded as reviewed estimates fell to 19,000 by 2014. However, variability in the total canonical protein counts (i.e. excluding alternative splice forms) of open reading frames (ORFs) in different annotation portals persists. This work assesses these differences and possible causes. A 16-year analysis of Ensembl and UniProtKB/Swiss-Prot shows convergence to a protein number of ~20,000. The former had shown some yo-yoing, but both have now plateaued...
2017: F1000Research
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