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Hemorheology

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https://www.readbyqxmd.com/read/29331744/urinary-metabolomics-study-the-mechanism-of-taohong-siwu-decoction-intervention-in-acute-blood-stasis-model-rats-based-on-liquid-chromatography-coupled-to-quadrupole-time-of-flight-mass-spectrometry
#1
Xiaosong Zhang, Pengling Li, Yongli Hua, Peng Ji, Wanling Yao, Qi Ma, Ziwen Yuan, Yanqiao Wen, Chaoxue Yang, Yanming Wei
Taohong Siwu Decoction (TSD) is a classic prescription in traditional Chinese medicine and is widely used to promote blood circulation to remove blood stasis. However, the effect mechanisms are not yet well understood. Here, a urinary metabolomic approach based on liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (LC/Q-TOF-MS) was conducted to explore the changes in the endogenous metabolites and to assess the integral efficacy of TSD on acute blood stasis model rats. Then, parameters for hemorheology and coagulation functions were detected...
January 2, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29326492/hemorheological-effects-of-amlodipine-in-spontaneously-hypertensive-rats
#2
Aleksandr Y Shamanaev, Oleg I Aliev, Anna M Anishchenko, Anastasia V Sidehmenova, Mark B Plotnikov
OBJECTIVES: The effect of course administration of amlodipine on whole blood viscosity and on macro- and microrheological parameters was evaluated. MATERIALS AND METHODS: SHRs were treated intragastrically with amlodipine at a dose of 10 mg/kg for 6 weeks. After finishing the course, hemodynamic and hemorheological parameters were measured. RESULTS: The antihypertensive treatment with amlodipine resulted in a significant decrease in mean blood pressure by 29% and left ventricular to body weight mass index by 7%...
July 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29317973/association-of-hemorheology-with-high-sensitivity-cardiac-troponin-t-levels-in-patients-with-type-2-diabetes-mellitus-assessed-by-microchannel-array-flow-analyzer
#3
Takashi Hitsumoto
Background: Recent studies on high-sensitivity cardiac troponin T (hs-cTnT) and whole blood passage time (WBPT), estimated by hemorheology assessed with the microchannel array flow analyzer (MC-FAN), have revealed the significance of cardiovascular risk factors. However, there are no known reports on the relationship between these two clinical parameters. This cross-sectional study aimed to clarify the associations between WBPT and hs-cTnT levels in patients with type 2 diabetes mellitus from the perspective of subclinical myocardial injury or the primary prevention of cardiovascular events...
December 2017: Cardiology Research
https://www.readbyqxmd.com/read/29316749/-effects-of-baicalin-on-the-changes-in-hemorheology-of-acute-respiratory-distress-syndrome-in-rats
#4
Z M Zhao, Y M Zheng, Y L Zhang, S Q Li
Objective: To investigate the effect of baicalin on the changes in hemorheology and its mechanism during the development of Acute Respiratory Distress Syndrome(ARDS) induced by oleic acid (OA) in rats. Methods: Rats were randomized into 3 groups: control, ARDS (OA induction, 0.12 mg/kg) and ba-icalin-treated group (300 mg/kg). The blood samples were collected at 30 min, 1, 2, 3, 6, 12 and 6 h after OA injection. The whole blood viscosity, plasma viscosity, Maximum erythrocyte deformability index (DImax) were detected...
November 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29171989/comparative-analysis-of-immune-function-hemorheological-alterations-and-prognosis-in-colorectal-cancer-patients-with-different-traditional-chinese-medicine-syndromes
#5
Cheng-Yang Wang, Huan-Zhang Ding, Xiao Tang, Ze-Geng Li
OBJECTIVE: The present study investigates the differences in immune function, hemorheological alterations and prognostic evaluation in colorectal cancer (CRC) patients with different traditional Chinese medicine (TCM) syndromes. METHODS: A total of 128 patients, diagnosed as stage II and III of CRC, were recruited. They were assigned into three TCM syndromes: deficiency syndrome, excess syndrome, and syndrome of intermingled deficiency and excess, and another 53 healthy individuals were selected as the control...
November 17, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29149492/effects-of-tao-hong-si-wu-decoction-on-acute-blood-stasis-in-rats-based-on-a-lc-q-tof-ms-metabolomics-and-network-approach
#6
Qi Ma, Peng-Ling Li, Yong-Li Hua, Peng Ji, Wan-Ling Yao, Xiao-Song Zhang, Li-Jia Zhong, Yan-Ming Wei
A novel approach using metabolomics coupled with a metabolic network was used to investigate the effects of THSWD on the rat model of acute blood stasis syndrome. Acute blood stasis syndrome was induced by placing the rats in ice-cold water following two injections with epinephrine. The hemorheological indicators (WBV and PV), and the blood coagulation indicators (TT, PT, APTT, and FIB) were detected. The nonparametric univariate method and multivariate statistical analysis were performed for determining the potential biomarkers...
November 17, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29139273/-comparative-study-on-promoting-blood-effects-of-danshen-honghua-herb-pair-with-different-preparations-based-on-chemometrics-and-multi-attribute-comprehensive-index-methods
#7
Cheng Qu, Yu-Ping Tang, Xu-Qin Shi, Gui-Sheng Zhou, Er-Xin Shang, Li-Li Shang, Jian-Ming Guo, Pei Liu, Jing Zhao, Bu-Chang Zhao, Jin-Ao Duan
To evaluate the promoting blood circulation and removing blood stasis effects of Danshen-Honghua(DH) herb pair with different preparations (alcohol, 50% alcohol and water) on blood rheology and coagulation functions in acute blood stasis rats, and optimize the best preparation method of DH based on principal component analysis(PCA), hierarchical cluster heatmap analysis and multi-attribute comprehensive index methods. Ice water bath and subcutaneous injection of adrenaline were both used to establish the acute blood stasis rat model...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29089816/impaired-hemorheology-in-exacerbations-of-copd
#8
Erhan Ugurlu, Emine Kilic-Toprak, Ilknur Can, Ozgen Kilic-Erkek, Goksel Altinisik, Melek Bor-Kucukatay
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation. Cardiovascular-related comorbidities are established to contribute to morbidity and mortality especially during exacerbations. The aim of the current study was to determine alterations in hemorheology (erythrocyte aggregation, deformability) in newly diagnosed COPD patients and their response to medical treatment and to compare with values of COPD patients with exacerbations. MATERIALS AND METHODS: The study comprised 13 COPD patients, 12 controls, and 16 COPD patients with exacerbations...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29077517/therapeutic-efficacy-of-methazolamide-against-intermittent-hypoxia-induced-excessive-erythrocytosis-in-rats
#9
Zhiqing Zhang, Zhonghai Xiao, Bingnan Deng, Xiaohua Liu, Wei Liu, Hongjing Nie, Xi Li, Zhaoli Chen, Danfeng Yang, Ruifeng Duan
Zhang, Zhiqing, Zhonghai Xiao, Bingnan Deng, Xiaohua Liu, Wei Liu, Hongjing Nie, Xi Li, Zhaoli Chen, Danfeng Yang, and Ruifeng Duan. Therapeutic efficacy of methazolamide against intermittent hypoxia-induced excessive erythrocytosis in rats. High Alt Med Biol 00:000-000, 2017.-This study aimed to determine whether methazolamide is effective for the treatment of chronic mountain sickness. Forty-eight male Wistar rats were randomly divided into eight groups: normoxia control, hypoxia control, hypoxia + acetazolamide (30 mg·kg(-1)·d(-1)), and five hypoxia + methazolamide groups (5, 10, 30, 90, and 120 mg·kg(-1)·d(-1))...
October 27, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29042907/effects-of-puerarin-combined-with-conventional-therapy-on-ischemic-stroke
#10
Min Yuan, Guijiang Liu, Xiuqi Zheng, Pei Li, Jinghua Liu, Sujie Wang, Yibin Cao
This study evaluated the use of conventional therapy combined with puerarin on ischemic stroke. Eighty patients with ischemic stroke admitted to Tangshan Gongren Hospital from March 2014 to September 2015 were randomly divided into two groups. The control group was treated with conventional therapy. The observation group was treated with an additional puerarin injection of 400 mg/day. The patients in both groups were examined for clinical neurological signs and symptoms. The levels of biochemical markers as well as changes in hemorheology were measured after the intervention and compared among the groups...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29036799/hemorheological-parameters-in-monoclonal-gammopathy-of-undetermined-significance-mgus
#11
G Caimi, E Hopps, M Carlisi, M Montana, E Gallà, R Lo Presti, S Siragusa
There is scarcity of information about the hemorheological pattern in subjects with Monoclonal Gammopathy of Undetermined Significance (MGUS). This preliminary research is focused on the behaviour of whole-blood and plasma viscosity, haematocrit and erythrocyte deformability in the above clinical condition. We enrolled 21 MGUS subjects (10 women and 11 men; mean age 66.4 ± 11.6 years). In fasting venous blood we examined whole-blood and plasma viscosity at high and low shear rates, haematocrit, the ratios between whole-blood viscosity (at high and low shear rate) and haematocrit × 100, the ratio between plasma viscosity at low and high shear rate, and the erythrocyte deformability expressed as elongation index...
October 7, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29036795/erythrocyte-deformability-and-hemorheological-profile-in-multiple-myeloma
#12
G Caimi, M Carlisi, M Montana, E Gallà, R Lo Presti, E Hopps, S Siragusa
The hemorheological profile in multiple myeloma (MM) has been extensively studied. Our investigation regarded the behavior of whole-blood viscosity, plasma viscosity and erythrocyte deformability in MM. We enrolled 24 MM patients; 13 of them had been recently diagnosed and were at the initial stage of therapy, 6 were on consolidation/conservation therapy and 5 had achieved a complete remission. On fasting venous blood we evaluated whole-blood and plasma viscosity at high and low shear rates, haematocrit, the ratios between whole-blood viscosity (at high and low shear rate) and haematocrit×100, the ratio between plasma viscosity at low and high shear rate and the erythrocyte deformability examined by using laser diffractometry and expressed as elongation index...
October 7, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28989072/pentoxifylline-treatment-enhances-antihypertensive-activity-of-captopril-through-hemorheological-improvement-in-spontaneously-hypertensive-rats-during-development-of-arterial-hypertension
#13
Mark B Plotnikov, Alexander Y Shamanaev, Oleg I Aliev, Anastasia V Sidekhmenova, Anna M Anishchenko, Alexander M Arkhipov
The rheological properties of blood play a significant role in the onset and progression of arterial hypertension. The aim of our work was to evaluate the effect of the angiotensin-converting enzyme inhibitor captopril (20 mg/kg/d), pentoxifylline (PTX; 100 mg/kg/d), and the combination of captopril + PTX (20 + 100 mg/kg/d) on the hemodynamic and hemorheological parameters in spontaneously hypertensive rats (SHRs) during the development of arterial hypertension. In the group of animals that received captopril, the mean arterial pressure (MAP) was significantly lower by 30% due to a decrease in cardiac output of 23% and in total peripheral resistance (TPR) of 26% compared with the control group, whereas blood viscosity did not change significantly...
November 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28966701/in-vitro-particulate-analogue-fluids-for-experimental-studies-of-rheological-and-hemorheological-behavior-of-glucose-rich-rbc-suspensions
#14
Diana Pinho, Laura Campo-Deaño, Rui Lima, Fernando T Pinho
Suspensions of healthy and pathological red blood cells (RBC) flowing in microfluidic devices are frequently used to perform in vitro blood experiments for a better understanding of human microcirculation hemodynamic phenomena. This work reports the development of particulate viscoelastic analogue fluids able to mimic the rheological and hemorheological behavior of pathological RBC suspensions flowing in microfluidic systems. The pathological RBCs were obtained by an incubation of healthy RBCs at a high concentration of glucose, representing the pathological stage of hyperglycaemia in diabetic complications, and analyses of their deformability and aggregation were carried out...
September 2017: Biomicrofluidics
https://www.readbyqxmd.com/read/28954968/renin-angiotensin-system-inhibitors-can-prevent-intravenous-lipid-infusion-induced-myocardial-microvascular-dysfunction-and-leukocyte-activation
#15
Takanori Yasu, Akiko Mutoh, Hiroshi Wada, Mayumi Kobayashi, Yuji Kikuchi, Shinichi Momomura, Shinichiro Ueda
BACKGROUND: Levels of triglycerides and free fatty acids (FFAs) are elevated in patients with diabetes and may contribute to endothelial dysfunction through renin-angiotensin system (RAS) activation and oxidative stress. The present study investigated how systemic FFA loading affected myocardial microcirculation during hyperemia via RAS.Methods and Results:Eight healthy men received candesartan, perindopril, or a placebo for 2 days in a double-blind crossover design, and then myocardial microcirculation during hyperemia induced by a 2-h infusion of lipid/heparin was assessed using dipyridamole stress-myocardial contrast echocardiography (MCE)...
September 26, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28943530/prescription-optimization-and-oral-bioavailability-study-of-salvianolic-acid-extracts-w-o-w-multiple-emulsion
#16
Yanqing Song, Huan Gao, Sixi Zhang, Yue Zhang, Xiangqun Jin, Jingmeng Sun
The purpose of this study is to develop a new method of preparing salvianolic acid extracts (SAE) water-in-oil-in-water (W/O/W) multiple emulsion (ME). SAE injection is used in the treatment of brain infarct and promotion of blood circulation in China. However, the injection is not convenient, and the oral preparation has poor bioavailability. Hence, a new preparation that is convenient and stable with good biological availability is required. SAE ME was prepared by two-step emulsification method. Combined with single-factor investigation and orthogonal test, the embedding rate and centrifugal retention rate were taken as the comprehensive indexes to optimize the formulation of SAE ME...
September 23, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28929689/-comparatively-evaluating-effect-contribution-of-promoting-blood-circulation-of-herb-pairs-containing-angelicae-sinensis-radix-on-xin-sheng-hua-granule-by-withdrawal-analysis
#17
Han-Qing Pang, Jun Wang, Yu-Ping Tang, Liang Wu, Hui-Qin Xu, Yi Jin, Zhen-Hua Zhu, Sheng-Liang Huang, Da-Zheng Sun, Jin-Ao Duan
Xin-Sheng-Hua granule (XSHG) is a popular remedy commonly used in clinic for the treatment of lochiostasis after delivery. To comparatively investigate the roles of herb pairs containing Angelicae Sinensis Radix (Danggui) upon the formula by evaluating the blood coagulation and hemorheology function in acute blood stasis rats, acute blood stasis rat model was established by ice water bath and subcutaneous injection of adrenaline. And the blood stasis mice were administrated intragastrically with different samples of the formula minus herb pairs containing Danggui and the whole formula (XSHG, SHD, DY, DC, DT, DH, DJ and DZ)...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28925467/effects-of-rosuvastatin-on-pentraxin-3-level-and-platelet-aggregation-rate-in-elderly-patients-with-acute-myocardial-infarction-undergoing-elective-interventional-therapy-a-double-blind-controlled-study
#18
Y-H Li, L-H Wang, Q Li, D-W Yu, Y-S Gai, S-X Cai, F Tian, H-Y Zhou
OBJECTIVE: To investigate clinical effects of rosuvastatin on blood lipid levels, hemorheological profiles, vascular endothelial function, pentraxin 3 (PTX-3) level, the number of granule membrane glycoprotein (GMP-140) molecules and platelet aggregation rate in elderly patients with acute myocardial infarction (AMI) undergoing elective percutaneous coronary intervention (PCI). PATIENTS AND METHODS: Total of 120 elderly patients admitted with AMI undergoing elective PCI from July 2014 to January 2016 were selected...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28919343/characterizing-pathology-in-erythrocytes-using-morphological-and-biophysical-membrane-properties-relation-to-impaired-hemorheology-and-cardiovascular-function-in-rheumatoid-arthritis
#19
Oore-Ofe O Olumuyiwa-Akeredolu, Prashilla Soma, Antoinette V Buys, Legesse Kassa Debusho, Etheresia Pretorius
The inflammatory burden of the complex rheumatoid arthritis (RA) disease affects several organ-systems, including rheological properties of blood and its formed elements. Red blood cells (RBCs) are constantly exposed to circulating dysregulated inflammatory molecules that are co-transported within the vasculature; and their membranes may be particularly vulnerable to the accompanying oxidative stress. In the current study, we investigate biophysical and ultrastructural characteristics of RBCs obtained from a cohort of patients using atomic force microscopy (AFM), scanning electron microscopy (SEM) and confocal microscopy (CM)...
December 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28889793/hemorheological-dysfunction-in-cardiac-syndrome-x
#20
Emine Kilic-Toprak, Olga Yaylali, Yalin Tolga Yaylali, Yasin Ozdemir, Dogangun Yuksel, Hande Senol, Tarık Sengoz, Melek Bor-Kucukatay
BACKGROUND: Cardiac syndrome X (CSX) is often described as angina or angina-like chest pain with a normal coronary arteriogram, yet the underlying pathophysiological mechanisms have not been fully elucidated. The aim of the current study was to determine alterations in blood rheology (erythrocyte aggregation and deformability, plasma viscosity - PV) in patients with CSX. METHODS: The study comprised 26 CSX patients (55.77 ± 12.33 years) and 37 age- and sex-matched (56...
September 11, 2017: Acta Cardiologica
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