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Hemorheology

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https://www.readbyqxmd.com/read/29758932/blood-rheology-during-normal-pregnancy
#1
Panagiotis Tsikouras, Barbara Niesigk, Georg-Friedrich von Tempelhoff, Werner Rath, Olga Schelkunov, Peter Daragó, Roland Csorba
INTRODUCTION: Recent studies have shown increased RBC aggregation and no difference in plasma viscosity in the presence of markedly lower hematocrit in women at term compared to non-pregnant women. Little is known about the outcome of blood rheological parameters and red blood cell (RBC) deformability particularly in the course of normal pregnancy. METHODS: During a 36 months interval 1.913 blood samples were randomly collected from a total of 945 pregnant women in the course of their pregnancy (n = 1...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29742453/effect-of-p-tyrosol-on-hemorheological-parameters-and-cerebral-capillary-network-in-young-spontaneously-hypertensive-rats
#2
Mark B Plotnikov, Oleg I Aliev, Anastasia V Sidekhmenova, Alexander Y Shamanaev, Anna M Anishchenko, Tatiana I Fomina, Tatiana M Plotnikova, Alexander M Arkhipov
BACKGROUND: Many pathological mechanisms are involved in the development of arterial hypertension; disturbance of the rheological properties of blood and microvascular rarefaction are among those mechanisms. OBJECTIVE: The effect of p-tyrosol (Tyr) on hemorheological parameters and microvascularization in the cerebral cortex of spontaneously hypertensive rats (SHRs) at the stage of blood pressure rising (5-11 weeks) was studied. METHODS: Blood viscosity (BV), plasma viscosity (PV), hematocrit, erythrocyte aggregation and deformability, the oxygen transport capacity index (OTCI), and the capillary network in the cerebral cortex after the course of treatment of Tyr (50 mg/kg daily i...
May 6, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29710698/erythrocyte-deformability-and-eryptosis-during-inflammation-and-impaired-blood-rheology
#3
E Pretorius
OBJECTIVE: This review focusses on the erythrocytes (RBCs) and their structural changes during inflammation and impaired blood rheology. We discuss systemic inflammation and the effects of dysregulated inflammatory molecules. These pro-inflammatory molecules directly affect the haematological system, and particularly the RBCs, platelets and plasma proteins. We focus on the three main changes; increased RBC eryptosis (programmed cell death, similar to apoptosis) and pathological deformability, platelet hyperreactivity and anomalous blood clotting, due to pathological changes to fibrin(ogen) protein structure...
April 14, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29710694/seeking-the-optimal-hematocrit-may-hemorheological-modelling-provide-a-solution
#4
Jean-Frédéric Brun, Emmanuelle Varlet-Marie, Marlène Richou, Eric Raynaud de Mauverger
Hematocrit increases during exercise and is usually decreased after regular training. However the interpretation of these facts is ambiguous since hematocrit is both a determinant of oxygen supply and the major determinant of blood viscosity. Classically hematocrit was assumed to impair blood flow, but it has been evidenced to exert a biphasic effect on it. In order to cope with these two apparently opposite effects of hematocrit, hemorheologists have proposed the concept hematocrit/viscosity ratio (h/η). This h/η ratio is related to tissue oxygenation in vascular diseases (eg, POAD) but not in healthy subjects...
April 14, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29710693/the-eschm-1st-hemorheology-days-19-21-july-2017-in-puchberg-schneeberg-austria
#5
Jean-Frédéric Brun, Ursula Windberger
No abstract text is available yet for this article.
April 14, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29710691/beta-estradiol-and-ethinylestradiol-enhance-rbc-deformability-dependent-on-their-blood-concentration
#6
Paulo L Farber, Teresa Freitas, Carlota Saldanha, Ana Santos Silva-Herdade
BACKGROUND: Natural and synthetic estrogens seems to have opposite effects on thrombosis and female cardiovascular system, since natural estrogen was supposed to be protective against cardiovascular diseases and synthetic estrogen has been related to thrombosis and cardiovascular diseases. In this work we have investigated if these differences could be related with the effects on those hormones on some hemorheological parameters. OBJECTIVE: The objective of this work was to investigate the hemorheological changes of different concentrations of beta-estradiol and ethinylestradiol, on RBC aggregation and RBC deformability...
April 14, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29710685/beneficial-effects-of-remote-organ-ischemic-preconditioning-on-micro-rheological-parameters-during-liver-ischemia-reperfusion-in-the-rat
#7
Zsuzsanna Magyar, Anita Mester, Gabor Nadubinszky, Gabor Varga, Souleiman Ghanem, Viktoria Somogyi, Bence Tanczos, Adam Deak, Laszlo Bidiga, Mihai Oltean, Katalin Peto, Norbert Nemeth
BACKGROUND: Remote ischemic preconditioning (RIPC) can be protective against the damage. However, there is no consensus on the optimal amount of tissue, the number and duration of the ischemic cycles, and the timing of the preconditioning. The hemorheological background of the process is also unknown. OBJECTIVE: To investigate the effects of remote organ ischemic preconditioning on micro-rheological parameters during liver ischemia-reperfusion in rats. METHODS: In anesthetized rats 60-minute partial liver ischemia was induced with 120-minute reperfusion (Control, n = 7)...
April 14, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29710681/effects-of-ex-vivo-aging-and-storage-temperature-on-blood-viscosity
#8
Jeffrey S Horner, Antony N Beris, Donna S Woulfe, Norman J Wagner
BACKGROUND: Research on hemorheology is driven in part by its significance in blood diseases and the possible use of hemorheology as a diagnostic tool. However, existing data on blood rheology are limited largely to measurements of steady shear behavior often with varying measurement protocols and insufficient characterization of the physiology. OBJECTIVE: The effects of ex vivo aging and environmental conditions on blood viscosity are investigated to improve standards for hemorheology measurements...
April 14, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29710679/effects-of-polymer-coated-boron-nitrides-with-increased-hemorheological-compatibility-on-human-erythrocytes-and-blood-coagulation
#9
Jeong-Ho Kim
BACKGROUND: Boron nitride (BN) nanomaterials are promising in biomedical research owing to their large surface area, graphene-like structure, and chemical and thermal properties. However, the toxicological effects of BN on erythrocytes and blood coagulation remain uninvestigated. OBJECTIVE: The aims of our study were to synthesize glycol chitosan (GC)- and hyaluronic acid (HA)-coated BNs, and to investigate the effects of these BNs on human cancer cells, erythrocytes, and whole blood...
April 14, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29704205/analysis-of-the-relationship-between-hemorheologic-parameters-aluminum-manganese-and-selenium-in-smokers
#10
Fatma Ates Alkan, Denizhan Karis, Gulfidan Cakmak, Alev Meltem Ercan
Smoking is a significant risk factor in fatal pathologies including cardio-cerebrovascular and respiratory diseases. Aluminum (Al) is a toxic element without known biological function, but with recognized toxic effects. Manganese (Mn) and selenium (Se) are essential trace elements involved in cellular antioxidant defense mechanisms. Al, Mn, and Se carry out their metabolic activities via blood flow and tissue oxygenation. The structure and number of red blood cells (RBC) play important role in tissue oxygenation throughout blood flow...
April 27, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29698457/rapid-weight-reduction-does-not-impair-athletic-performance-of-taekwondo-athletes-a-pilot-study
#11
Woo-Hwi Yang, Oliver Heine, Marijke Grau
In combat sports such as taekwondo (TKD), athletes rapidly reduce body weight to achieve a desired weight category. Competition takes place 16-24 h after weigh-in and thus, the recovery time is an important factor for competition performance. The purpose of this study was to investigate the impact of rapid weight reduction (RWR) on athletic performance and associated hemorheological properties considering relevant recovery time. Five male TKD athletes reduced body weight by 5% within 3½ days. A simulated competition day (SCD) was carried out after a 16 h recovery period...
2018: PloS One
https://www.readbyqxmd.com/read/29687874/effects-of-platelet-rich-plasma-on-angiogenesis-and-osteogenesis-associated-factors-in-rabbits-with-avascular-necrosis-of-the-femoral-head
#12
X-L Zhang, K-Q Shi, P-T Jia, L-H Jiang, Y-H Liu, X Chen, Z-Y Zhou, Y-X Li, L-S Wang
OBJECTIVE: Platelet-rich plasma (PRP) contains various growth factors and cytokines that can enhance the recovery of the damaged tissues. The present study aimed to examine the effects of PRP on the recovery of avascular necrosis of the femoral head (ANFH), and to provide novel insights into the clinical treatment of this disease. MATERIALS AND METHODS: A total of 24 New Zealand white rabbits were randomly divided into the normal control group, ANFH model and PRP-treated groups (n =1 2 each)...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29682144/periodic-and-simultaneous-quantification-of-blood-viscosity-and-red-blood-cell-aggregation-using-a-microfluidic-platform-under-in-vitro-closed-loop-circulation
#13
Yang Jun Kang
To evaluate variations of blood circulating in closed loops, hemorheological properties including blood viscosity and red blood cells (RBCs) are quantitatively measured with independent in-vitro instruments after collecting blood from a closed loop. But, most previous methods require periodic blood collections which induce several problems such as geometric differences between the fluidic channel and the in-vitro method, hemodilution, storage time, and unspecific blood flow rates. To resolve these issues, in this study, blood viscosity and RBC aggregation of blood circulating within a closed loop are measured with a microfluidic platform periodically and simultaneously...
March 2018: Biomicrofluidics
https://www.readbyqxmd.com/read/29676545/hemorheologic-alterations-in-patients-with-type-2-diabetes-mellitus-presented-with-an-acute-myocardial-infarction
#14
Kyu Hwan Park, Ung Kim, Kang Un Choi, Jong Ho Nam, Jung Hee Lee, Chan Hee Lee, Jang Won Son, Jong Seon Park, Dong Gu Shin, Kyu Chang Won, Jun Sung Moon, Yu Kyung Kim, Jang Soo Suh
BACKGROUND: Hemorheologic indices are known to be related to vascular complications in variable clinical settings. However, little is known about the associations between hemorheologic parameters and acute myocardial infarction (AMI) in type 2 diabetes mellitus (T2DM). The purpose of this study was to demonstrate the changes of hemorheologic environment inside of blood using hemorheologic parameters, especially the elongation index (EI) and critical shear stress (CSS) in diabetics with versus without AMI...
April 2018: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/29676140/-effect-of-shenqi-dihuang-decoction-on-inflammatory-factor-renal-function-and-microcirculation-in-patients-with-early-diabetic-nephropathy
#15
Ming-Rui Wang, Li-Hua Yu, Ting-Ting Wang, Ye-Mei Wang, Ming-Xiang Han
To study the effect of Shenqi Dihuang decoction on inflammatory factor, renal function and microcirculation in patients with early diabetic nephropathy. A total of 205 cases of patient with early diabetic nephropathy treated in our hospital from March 2014 to April 2016 were selected and divided into two groups according to the admitted order, with 103 cases in clinical group and 102 in control group. Patients in control group were treated with melbine and captopril, which may be adjusted according to the clinical symptom...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29674944/dunye-guanxinning-improves-acute-myocardial-ischemia-reperfusion-injury-by-inhibiting-neutrophil-infiltration-and-caspase-1-activity
#16
Q G Zhang, S R Wang, X M Chen, H N Guo, S Ling, J W Xu
Acute myocardial infarction is the most serious manifestation of cardiovascular disease, and it is a life-threatening condition. Dunye Guanxinning (DG) is a protective traditional Chinese patent herbal medicine with high clinical efficacy and suitable for the treatment of myocardial infarction. However, the mechanism through which it is beneficial is unclear. In this study, we hypothesized that DG improves acute myocardial ischemia-reperfusion injury by inhibiting neutrophil infiltration and caspase-1 activity...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29660915/hemorheological-and-metabolic-consequences-of-renal-ischemia-reperfusion-and-their-modulation-by-n-n-dimethyl-tryptamine-on-a-rat-model
#17
Katalin Peto, Norbert Nemeth, Anita Mester, Zsuzsanna Magyar, Souleiman Ghanem, Viktoria Somogyi, Bence Tanczos, Adam Deak, Laszlo Bidiga, Ede Frecska, Balazs Nemes
BACKGROUND: Micro-rheological relations of renal ischemia-reperfusion (I/R) have not been completely elucidated yet. Concerning anti-inflammatory agents, it is supposed that sigma-1 receptor agonist N,N-dimethyl-tryptamin (DMT) can be useful to reduce I/R injury. OBJECTIVE: To investigate the micro-rheological and metabolic parameters, and the effects of DMT in renal I/R in rats. METHODS: In anesthetized rats from median laparotomy both kidneys were exposed...
April 13, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29660912/increased-plasma-viscosity-in-plasma-cell-dyscrasia-and-whole-blood-viscosity-in-polycythemia-vera
#18
Dong Woo Shin, Ja-Yoon Gu, Jun Sik Kim, Jae-Seol Jung, Dong-Yeop Shin, Youngil Koh, Inho Kim, Hyun Kyung Kim
BACKGROUND: Although hyperviscosity syndrome in plasma cell dyscrasia (PCD) and thrombosis in myeloproliferative neoplasm (MPN) are major causes of morbidity and mortality, blood viscosity measurements are often underutilized. OBJECTIVE: This study aimed to characterize whether whole blood viscosity (WBV) or plasma viscosity (PV) could be predictive of hyperviscosity syndrome in PCD and could be elevated in subgroups of MPN. METHODS: A total of 75 patients with hematologic diseases: PCD (n = 26), MPN (n = 25) including polycythemia vera (P...
April 13, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29660906/viscometer-validation-studies-for-routine-and-experimental-hemorheological-measurements
#19
David Kovacs, Kinga Totsimon, Katalin Biro, Peter Kenyeres, Istvan Juricskay, Gabor Kesmarky, Kalman Toth, Andras Toth
BACKGROUND: Viscosity measurement is challenging due to the internal properties of blood and the artifacts deriving from the various viscometer systems. OBJECTIVE: We aimed to determine the pitfalls of a cone-plate viscometer (Brookfield DV-III Ultra LV) before starting measurements and compare it to our capillary type model (Hemorex Hevimet 40). Effects of sample storage and thermal calibration were assessed as well. METHODS AND RESULTS: Intra-observer variability was studied by 10 replicate measurements of 7 blood samples, mean coefficients of variation were less than 5%...
April 13, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29614631/simple-chronic-transfusion-therapy-a-crucial-therapeutic-option-for-sickle-cell-disease-improves-but-does-not-normalize-blood-rheology-what-should-be-our-goals-for-transfusion-therapy
#20
Jon A Detterich
Sickle cell anemia is characterized by a mutation resulting in the formation of an abnormal beta-hemoglobin called hemoglobin S. Hemoglobin S polymerizes upon deoxygenation, causing impaired red blood cell deformability and increased blood viscosity at equivalent hematocrits. Thus, sickle cell disease is a hemorheologic disease that results in various pathologic processes involving multiple organ systems including the lungs, heart, kidneys and brain. Red blood cell mechanics and the perturbations on blood flow-endothelial interaction underlie much of the pathology found in sickle cell disease...
2018: Clinical Hemorheology and Microcirculation
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