Simona Ruxandra Volovat, Dragos Viorel Scripcariu, Ingrid Andrada Vasilache, Cati Raluca Stolniceanu, Constantin Volovat, Iolanda Georgiana Augustin, Cristian Constantin Volovat, Madalina-Raluca Ostafe, Slevoacă-Grigore Andreea-Voichița, Toni Bejusca-Vieriu, Cristian Virgil Lungulescu, Daniel Sur, Diana Boboc
Oncolytic viruses (OVs) are emerging as potential treatment options for cancer. Natural and genetically engineered viruses exhibit various antitumor mechanisms. OVs act by direct cytolysis, the potentiation of the immune system through antigen release, and the activation of inflammatory responses or indirectly by interference with different types of elements in the tumor microenvironment, modification of energy metabolism in tumor cells, and antiangiogenic action. The action of OVs is pleiotropic, and they show varied interactions with the host and tumor cells...
January 18, 2024: International Journal of Molecular Sciences