keyword
https://read.qxmd.com/read/38326460/did-the-covid-19-pandemic-have-an-effect-on-oral-cancer-staging-a-single-centre-retrospective-observational-study
#21
JOURNAL ARTICLE
Joshua Lopez, Shadaab Mumtaz, Ali Amini
Introduction This study aims to assess if the COVID-19 pandemic impacted upon oral cancer staging in a single centre in the UK.Materials and methods Data were collected from the head and neck cancer database of a teaching hospital in London. Oral cancer diagnosis and staging in the peak period of the pandemic (March 2020-2021) were assessed against the one-year period (March 2019-2020) before the pandemic.Results In total, 25 cases of oral cancer were diagnosed in the pre-COVID-19 group compared to 26 in the COVID-19 cohort...
February 7, 2024: British Dental Journal
https://read.qxmd.com/read/38326404/re-irradiation-for-isolated-neck-recurrence-in-head-and-neck-tumor-impact-of-rn-category
#22
JOURNAL ARTICLE
Hideya Yamazaki, Gen Suzuki, Norihiro Aibe, Hiroya Shiomi, Ryoong-Jin Oh, Ken Yoshida, Satoaki Nakamura, Koji Konishi, Tomohiko Matsuyama, Mikio Ogita
Unresectable, isolated lymph node recurrence after radiotherapy is rare but a candidate for re-irradiation. However, severe toxicity is anticipated. Therefore, this study aimed to explore the efficacy and toxicity of re-irradiation in isolated lymph node recurrence of head and neck lesions. We analyzed 46 patients who received re-irradiation for lymph node recurrence without local progression. The primary tumor sites included the oral cavity in 17 patients, the hypopharynx in 12, the oropharynx in seven, the larynx in three, the nasopharynx in two, and other sites...
February 7, 2024: Scientific Reports
https://read.qxmd.com/read/38321926/unplanned-return-to-hospital-after-same-day-oral-cavity-resection-a-dual-institution-study
#23
JOURNAL ARTICLE
Aaron J Meers, James D Warren, Julia Dmowska, Anne C Kane, Patrick Tassone
OBJECTIVES: Primary objective: describe rates of 30-days unplanned readmission following outpatient resection of oral cavity cancer. Secondary objective: evaluate for patient and treatment factors associated with readmission. METHODS: Retrospective, dual-institution cohort study of 2 tertiary care referral centers involving adult patients undergoing resection of oral cavity cancer with plans for same-day discharge. Consecutive sample of 77 patients included. Primary outcome was unplanned readmission to emergency room or inpatient stay in the 30 days following surgery...
February 7, 2024: Annals of Otology, Rhinology, and Laryngology
https://read.qxmd.com/read/38318587/surgical-management-of-oral-cavity-cancer-experience-at-a-tertiary-care-centre-in-jamshedpur
#24
JOURNAL ARTICLE
Bijan K Saha, Sanghamitra Jena, Pankaj Singodia, Jayant K Lenka, Neetesh Sinha, Minakshi Mishra
Background Cancer of the oral cavity is very common in Eastern India. This is due to the lack of awareness that chewing tobacco causes oral cancer. Because of poor economic condition and lack of access to healthcare, patients in this region often present at an advanced stage of the disease when they become symptomatic. A retrospective study was conducted at Tata Main Hospital, Jamshedpur, India, to know the epidemiology and recurrence of oral cavity cancer in this region. Materials and methods We conducted a retrospective study of oral cavity cancer patients operated at Tata Main Hospital, Jamshedpur, from January 2018 to June 2023...
January 2024: Curēus
https://read.qxmd.com/read/38313967/comparison-of-broder-s-and-bryne-s-grading-system-for-oral-squamous-cell-carcinoma-with-lymph-node-metastases-and-prognosis-a-scoping-review
#25
REVIEW
Snega Thamilselvan, Deepak Pandiar, Reshma P Krishnan, Karthikeyan Ramalingam, Pinky Pavithran
Oral squamous cell carcinoma (OSCC) has the highest mortality rate of any type of head and neck squamous cell carcinoma. For many eons, the clinical TNM (tumor size, nodal metastasis, and distant metastasis) classification and histological grading of malignancies have been used to predict clinical behavior, confusing it with prognosis and overall survival. This review aimed to systematically identify and evaluate the prognostic value of Broder's and Bryne's grading system for OSCC. Electronic resources such as PubMed, Cochrane Database of Systematic Reviews, Google Scholar, Scopus, and direct web searches were used to conduct a thorough search...
January 2024: Curēus
https://read.qxmd.com/read/38312621/developing-a-robust-two-step-machine-learning-multiclassification-pipeline-to-predict-primary-site-in-head-and-neck-carcinoma-from-lymph-nodes
#26
JOURNAL ARTICLE
Jiaying Liu, Anna Corti, Giuseppina Calareso, Gaia Spadarella, Lisa Licitra, Valentina D A Corino, Luca Mainardi
This study aimed to develop a robust multiclassification pipeline to determine the primary tumor location in patients with head and neck carcinoma of unknown primary using radiomics and machine learning techniques. The dataset included 400 head and neck cancer patients with primary tumor in oropharynx, OPC (n = 162), nasopharynx, NPC (n = 137), oral cavity, OC (n = 63), larynx and hypopharynx, HL (n = 38). Two radiomic-based multiclassification pipelines (P1 and P2) were developed...
January 30, 2024: Heliyon
https://read.qxmd.com/read/38309587/disease-and-toxicity-outcomes-for-a-modern-cohort-of-patients-with-squamous-cell-carcinoma-of-cutaneous-origin-involving-the-parotid-gland-comparison-of-volumetric-modulated-arc-therapy-and-pencil-beam-scanning-proton-therapy
#27
JOURNAL ARTICLE
Reza Zarinshenas, Peter Campbell, Kai Sun, Jason K Molitoris, Akshar N Patel, Matthew E Witek, Kevin J Cullen, Ranee Mehra, Kyle M Hatten, Kelly F Moyer, Rodney J Taylor, Kalpesh T Vakharia, Jeffrey S Wolf, Matthew J Ferris
OBJECTIVES: We sought to describe outcomes for locally advanced cutaneous squamous cell carcinoma (SCC) involving the parotid treated with volumetric modulated arc therapy (VMAT) versus pencil beam scanning proton beam therapy (PBT). MATERIALS AND METHODS: Patients were gathered from 2016 to 2022 from 5 sites of a large academic RT department; included patients were treated with RT and had parotid involvement by: direct extension of a cutaneous primary, parotid regional spread from a previously or contemporaneously resected but geographically separate cutaneous primary, or else primary parotid SCC (with a cutaneous primary ostensibly occult)...
February 1, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38304281/challenging-differential-diagnosis-of-mandible-angle-metastasis-from-breast-cancer
#28
Francesca Spirito, Mariateresa Ambrosino, Federica Morrone, Roberto Duraccio, Lorenzo Lo Muzio, Antonio Della Valle
Breast cancer is the most common cancer in women and the second leading cause of cancer-related death. Breast cancer manifestations in the head and neck are relatively rare, and they are mostly bony metastasis to the mandible and maxilla. In this paper, we present a case report of a metastatic tumor in the mandibular angle originating from breast carcinoma. A 32-year-old female patient with a paresthesia/anesthesia in the left mandibular area was referred to us to aid in the differential diagnosis between osteonecrosis and metastasis...
2024: Case Reports in Dentistry
https://read.qxmd.com/read/38303862/evaluation-of-neck-control-strategies-for-oral-squamous-cell-carcinoma-of-stage-i-neck-dissection-or-potential-immunotherapy
#29
JOURNAL ARTICLE
Chengshuai Yang, Zirui Wang, Linjun Shi, Wei Liu
The neck control strategies of early-stage oral squamous cell carcinoma (OSCC) patients with clinical node-negative neck remain uncertain. These patients could be benefit from elective neck dissection (END) alongside primary tumor excision; but current evidence on END versus observation for OSCC of stage I only is not yet analyzed collectively in detail. Herein, this short communication aimed to evaluate the neck control strategies of stage I OSCC, mainly END versus observation. A total of 740 patients with stage I OSCC, comprising 434 underwent END and 306 received observation, were identified from literature...
January 2024: Journal of Dental Sciences
https://read.qxmd.com/read/38303833/association-of-higher-transient-receptor-potential-melastatin-8-expression-with-higher-tumor-histologic-grades-lymph-node-metastasis-risk-factors-and-worse-survival-in-patients-with-head-and-neck-squamous-cell-carcinoma
#30
JOURNAL ARTICLE
Nan-Chin Lin, Thanh-Hien Vu Nguyen, Yin-Hwa Shih, Yi-Hung Chen, Yen-Wen Shen, Kuo-Chou Chiu, Shih-Min Hsia, Tzong-Ming Shieh
BACKGROUND/PURPOSE: Transient receptor potential melastatin 8 (TRPM8), a thermosensitive ion channel known for its role in cold sensation and menthol response, has emerged as a potential regulator in various cancers. This study aimed to investigate expression trends of TRPM8 in head and neck squamous cell carcinoma (HNSCC) cases and oral squamous cell carcinoma (OSCC) cell lines and its association with clinicopathological features. MATERIALS AND METHODS: The noncancerous matched tissues and HNSCC paired tissue samples from 84 HNSCC patients were utilized to evaluate the association of TRPM8 with HNSCC clinicopathological features...
January 2024: Journal of Dental Sciences
https://read.qxmd.com/read/38303830/serpin-peptidase-inhibitor-clade-e-member-2-is-associated-with-malignant-progression-and-clinical-prognosis-in-oral-squamous-cell-carcinoma
#31
JOURNAL ARTICLE
Hao-Wen Chuang, Li-Han Lin, Dar-Der Ji, Ting-Ying Fu, Herng-Sheng Lee, Yi-Fang Yang, Hsing-Cheng Tseng, Kan-Tai Hsia
BACKGROUND/PURPOSE: The serpin peptidase inhibitor, clade E, member 2 (SERPINE2), is upregulated in breast cancer, prostate cancer, and urothelial carcinoma; however, limited information exists regarding its expression in oral cancer. Therefore, this study aimed to analyze the association between SERPINE2 expression and oral squamous cell carcinoma (OSCC) outcomes. MATERIALS AND METHODS: SERPINE2 mRNA and protein expression in patients with head and neck squamous cell carcinoma and OSCC were investigated using online databases and tissue-array analysis...
January 2024: Journal of Dental Sciences
https://read.qxmd.com/read/38303819/simultaneous-metastases-of-papillary-thyroid-carcinoma-and-oral-squamous-cell-carcinoma-in-the-cervical-lymph-nodes-of-neck-dissection-specimens
#32
JOURNAL ARTICLE
Ching-Yi Chen, Chih-Huang Tseng, Ching-Wei Hsu, Yuk-Kwan Chen
No abstract text is available yet for this article.
January 2024: Journal of Dental Sciences
https://read.qxmd.com/read/38293584/a-multi-centric-dataset-on-patient-individual-pathological-lymph-node-involvement-in-head-and-neck-squamous-cell-carcinoma
#33
JOURNAL ARTICLE
Roman Ludwig, Adrian Schubert, Dorothea Barbatei, Laurence Bauwens, Sandrine Werlen, Olgun Elicin, Matthias Dettmer, Philippe Zrounba, Panagiotis Balermpas, Bertrand Pouymayou, Vincent Grégoire, Roland Giger, Jan Unkelbach
DATASET: We provide a dataset on lymph node metastases in 968 patients with newly diagnosed head and neck squamous cell carcinoma (HNSCC). All patients received neck dissection and we report the number of metastatic versus investigated lymph nodes per lymph node level (LNL) for every individual patient. Additionally, clinicopathological factors including T-category, primary tumor subsite (ICD-O-3 code), age, and sex are reported for all patients. The data is provided as three datasets: Dataset 1 contains 373 HNSCC patients treated at Centre Léon Bérard (CLB), France, with primary tumor location in the oral cavity, oropharynx, hypopharynx, and larynx...
February 2024: Data in Brief
https://read.qxmd.com/read/38291013/when-should-patients-with-t1n0-oral-squamous-cell-carcinoma-be-considered-for-elective-neck-dissection
#34
JOURNAL ARTICLE
Anthony Noor, Manish D Mair, Ruta Gupta, Michael S Elliott, James Wykes, Carsten E Palme, Jonathan R Clark, Tsu-Hui Hubert Low
AIMS: To identify adverse pathological features (APF) predicting nodal failure in clinically node negative T1 oral squamous cell carcinoma (OSCC). METHODOLOGY: This study evaluated patients with T1N0 (≤5 mm depth of invasion (DOI) and ≤2 cm diameter) oral cancers from a prospectively maintained database between 1988 and 2020. All patients underwent surgical excision of the primary lesion without neck dissection. Patients underwent three monthly clinical surveillance and salvage neck dissection was performed if nodal relapse was diagnosed...
January 30, 2024: ANZ Journal of Surgery
https://read.qxmd.com/read/38288039/combination-treatment-with-paclitaxel-carboplatin-and-cetuximab-in-maxillary-sinus-cancer-a-case-report
#35
Masahiro Morimoto, Masashi Takano, Takehiko Sato, Shujiroh Makino
The standard treatment for maxillary sinus cancer is surgery; however, surgery for advanced cases often leads to significant aesthetic and functional disability. Combination treatment (induction chemotherapy) with paclitaxel, carboplatin and cetuximab (PCE) can be effective in head and neck cancer. The present study describes the case of a patient with advanced maxillary sinus cancer that was successfully treated using the PCE regimen. A 69-year-old man presented to the Department of Dentistry and Oral Surgery, Hokuto Hospital (Obihiro, Japan) with left buccal swelling and an irregular mass on the left maxillary gingiva...
March 2024: Oncology Letters
https://read.qxmd.com/read/38267767/occult-metastasis-is-no-burden-factor-in-oral-squamous-cell-carcinoma-patients-when-adhering-to-a-standardized-approach-in-neck-dissection
#36
JOURNAL ARTICLE
Ann-Kristin Struckmeier, Mayte Buchbender, Tobias Moest, Rainer Lutz, Abbas Agaimy, Marco Kesting
OBJECTIVES: Management of the neck in patients with oral squamous cell carcinoma (OSCC) is pivotal to oncologic control and survival. However, there is controversy regarding necessity of neck dissection (ND) in patients with clinically node-negative neck. We aimed to assess risk factors for occult metastasis and to explore whether the presence of occult lymph node metastases (LNMs) has an impact on recurrence and survival. MATERIAL AND METHODS: A retrospective cohort study was performed including patients with primary OSCC who underwent radical tumor resection and ND in a high-volume center adhering to the prevailing German guideline...
January 24, 2024: Clinical Oral Investigations
https://read.qxmd.com/read/38263290/cyclic-increase-in-the-adamts1-l1cam-egfr-axis-promotes-the-emt-and-cervical-lymph-node-metastasis-of-oral-squamous-cell-carcinoma
#37
JOURNAL ARTICLE
Ming-Hsien Chien, Yi-Chieh Yang, Kuo-Hao Ho, Yi-Fang Ding, Li-Hsin Chen, Wen-Kuan Chiu, Ji-Qing Chen, Min-Che Tung, Michael Hsiao, Wei-Jiunn Lee
The matrix metalloprotease A disintegrin and metalloprotease with thrombospondin motifs 1 (ADAMTS1) was reported to be involved in tumor progression in several cancer types, but its contributions appear discrepant. At present, the role of ADAMTS1 in oral squamous cell carcinoma (SCC; OSCC) remains unclear. Herein, The Cancer Genome Atlas (TCGA) database showed that ADAMTS1 transcripts were downregulated in head and neck SCC (HNSCC) tissues compared to normal tissues, but ADAMTS1 levels were correlated with poorer prognoses of HNSCC patients...
January 23, 2024: Cell Death & Disease
https://read.qxmd.com/read/38260311/orthotopic-injection-of-an-established-syngeneic-mouse-oral-cancer-cell-line-moc1-induces-a-robust-draining-lymph-node-response
#38
Vikash Kansal, Brendan L C Kinney, Nicole C Schmitt
BACKGROUND: Preclinical models are invaluable for studies on the pathogenesis and treatment of head and neck cancer. In recent years, there has been growing interest in the use of orthotopic syngeneic models, wherein head and neck cancer cell lines are injected into the oral cavity of immunocompetent mice. However, few such orthotopic models have been described in detail. In this brief report, we describe techniques for injection of mouse oral cancer 1 (MOC1) cells into the buccal mucosa and illustrate the tumor growth pattern, lymph node response, and changes in the tumor immune microenvironment over time...
January 14, 2024: bioRxiv
https://read.qxmd.com/read/38252704/prognostic-value-of-18-f-fdg-pet-radiomics-and-sarcopenia-in-patients-with-oral-squamous-cell-carcinoma
#39
JOURNAL ARTICLE
Yuxing Song, Ying Tian, Xinyan Lu, Gaoxiang Chen, Xiaozhi Lv
BACKGROUND: Oral cancer is one of the most common malignancies in the head and neck region. Approximately 90% of oral cancers are oral squamous cell carcinomas (OSCC). 18 F-FDG PET/CT has been used in OSCC patients for its high value in detecting metastatic lymph nodes and distant metastases. PET radiomics and sarcopenia can be measured on the PET and CT components of 18 F-FDG PET/CT. PURPOSE: This study aimed to investigate the prognostic value of radiomics and sarcopenia measured on the PET and CT components of pre-operation 18 F-FDG PET/CT in OSCC...
January 22, 2024: Medical Physics
https://read.qxmd.com/read/38247572/predictive-value-of-local-control-by-4-methyl-11c-thiotymidine-pet-volume-parameters-in-p16-negative-oropharyngeal-hypopharyngeal-and-supraglottic-squamous-cell-carcinoma
#40
JOURNAL ARTICLE
Yohei Ouchi, Takehito Kishino, Takenori Miyashita, Terushige Mori, Katsuya Mitamura, Takashi Norikane, Yuka Yamamoto, Hiroshi Hoshikawa
PURPOSE: We investigated the potential of baseline 4'-[methyl-11C]-thiothymidine ([11C]4DST) PET for predicting loco-regional control of head and neck squamous cell carcinoma (HNSCC). METHODS: A retrospective analysis was performed using volumetric parameters, such as SUVmax, proliferative tumor volume (PTV), and total lesion proliferation (TLP), of pretreatment [11C]4DST PET for 91 patients with HNSCC with primary lesions in the oral cavity, hypopharynx, supraglottis, and oropharynx, which included p16-negative patients...
January 22, 2024: Nuclear Medicine Communications
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