keyword
https://read.qxmd.com/read/38497861/magnetic-resonance-imaging-accuracy-in-assessing-depth-of-invasion-in-tongue-squamous-cell-carcinomas-and-predicting-cervical-nodal-metastasis
#1
JOURNAL ARTICLE
B Alharbi, M Alessa, H Alsayid, L Alareek, S Alqaryan, R Alqurayyan, R Alamoudi, D Alghamdi, K Alqahtani, S Aldhahri
OBJECTIVE: The aim of this study was to evaluate magnetic resonance imaging (MRI) accuracy in assessing the depth of invasion (DOI) compared to pathological DOI in oral tongue squamous cell carcinoma (SCC) and to determine whether MRI-measured DOI can predict lymph node metastasis in the cervical region. PATIENTS AND METHODS: This retrospective study comprised 36 patients diagnosed with oral tongue SCC who underwent head and neck MRI 1-30 days before surgery and were surgically treated at King Fahad Medical City between January 2017 and November 2022...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38497534/rate-of-occult-metastasis-in-lip-squamous-cell-carcinoma-a-systematic-review-and-meta-analysis
#2
JOURNAL ARTICLE
Sagar Kansara, Evrim Oral, Indrani Sarkar, Vlad Sandulache, Rula Mualla, Rohan R Walvekar, William Ryan, Patrick Ha
OBJECTIVES: The rate of occult metastasis in lip cancer is poorly studied. Management of the regional nodal basin in lip cancer is thus controversial. This study sought to understand the true rate of micrometastasis in lip cancer. MATERIALS AND METHODS: Systematic review and meta-analysis was conducted of English language studies reporting lip cancer sentinel node biopsy results. Studies were obtained from the PubMed database between the years 2000 and 2023 using the search terms "sentinel node biopsy" and "squamous cell carcinoma...
March 18, 2024: Head & Neck
https://read.qxmd.com/read/38495795/locally-advanced-oral-squamous-cell-carcinomas-auditing-and-outcome-appraisal
#3
JOURNAL ARTICLE
Rathindra Nath Bera, Richik Tripathi, Sapna Tandon, Mohd Adil, Sanober Sohail, Shashank, Avishek Chakraborty
UNLABELLED: Introduction: Patients with OSCC in India (oral squamous cell carcinoma) presents at a later stage with approximately 28% presenting at stage III and 64% at stage IV disease. In this retrospective study we have reviewed the treatment modalities rendered and outcomes associated for the management of locally advanced oral squamous cell carcinoma in our Institute. We evaluated the survival data and the factors effecting survival. Methods: Kaplan Meir method was used to evaluate OS and DFS rate and log rank test was used to compare the survival amongst groups...
February 2024: Indian Journal of Otolaryngology and Head and Neck Surgery
https://read.qxmd.com/read/38495489/impact-of-linc00312-gene-polymorphism-coupled-with-habitual-risks-on-buccal-mucosa-cancer
#4
JOURNAL ARTICLE
Hui-Ting Hsu, Yen-Ting Lu, Yi-Tzu Chen, Ming-Tai Hsing, Chun-Wen Su, Shih-Chi Su, Chiao-Wen Lin, Shun-Fa Yang
Oral squamous cell carcinoma (OSCC) is a prevalent and lethal malignancy with a diverse etiology. LINC00312 is a long intergenic non-coding RNA that functions as a signal hub to regulate the progression and treatment of head and neck cancer. The aim of this study was to evaluate the effect of LINC00312 single nucleotide polymorphisms (SNPs) on the development of oral cancer. Two LINC00312 SNPs, namely rs12497104 and rs164966, were investigated among 469 male patients with cancer of buccal mucosa and 1194 gender- and age-matched controls...
2024: Journal of Cancer
https://read.qxmd.com/read/38494969/-the-prognosis-of-neck-dissection-with-sternocleidomastoid-muscle-preservation-and-resection-in-advanced-oral-squamous-cell-carcinoma-a-retrospective-cohort-analysis
#5
JOURNAL ARTICLE
Xing-Jin Chen, Ran-Yi Fan, Shi-Cheng Tao, Rui Xue, Xu-Tao Wen, Hua-Ming Mai
PURPOSE: To investigate the prognosis of advanced oral squamous cell carcinoma (AOSCC) patients undergoing neck dissection with sternocleidomastoid muscle (SCM) preservation and resection. METHODS: From January 2013 to June 2017, a total of 235 AOSCC patients(stage Ⅲ and stage Ⅳ) who were diagnosed and underwent neck dissection at the Department of Oral and Maxillofacial Surgery, College and Hospital of Stomatology, Guangxi Medical University, were collected and followed-up...
December 2023: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://read.qxmd.com/read/38490491/proposals-for-the-delineation-of-neck-clinical-target-volume-for-definitive-radiation-therapy-in-patients-with-oral-oropharyngeal-squamous-cell-cancer-based-on-lymph-node-distribution
#6
JOURNAL ARTICLE
Yun-Chang Liu, Xin Zhang, Hao-Nan Yang, Lu Zhang, Dan Li, Meng-Qi Yang, Nuo-Han Wang, Yong-Zhong Wu, Jiang-Dong Sui, Ying Wang
PURPOSE/OBJECTIVE(S): To establish the distribution pattern of cervical lymph node metastasis (LNM) and propose optimized clinical target volume (CTV) boundaries specific to oral/ oropharyngeal squamous cell cancer (OSCC/OPSCC). MATERIALS/METHODS: 531 patients with pathologically confirmed OSCC/OPSCC were enrolled from January 2013 to June 2022. Patients were stratified into two groups based on the minimal distance from the lesion's edge to the body's midline: ≤1 cm or > 1 cm...
March 13, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38458548/association-between-lymph-node-ratio-and-survival-outcomes-in-patients-with-oral-squamous-cell-carcinoma
#7
JOURNAL ARTICLE
Kazuya Haraguchi, Manabu Habu, Osamu Takahashi, Kazuhiro Tominaga, Izumi Yoshioka, Masaaki Sasaguri
BACKGROUND: Recent reports have shown that the Lymph node ratio (LNR) is useful for predicting the prognosis in some cancers, however there are few reports on the usefulness of LNR in predicting the prognosis of oral squamous cell carcinoma (OSCC). The predictive value of LNR for prognosis of OSCC was investigated. MATERIALS AND METHODS: The study included 152 patients with OSCC and histologically confirmed cervical lymph node metastasis who underwent neck dissection...
March 6, 2024: Journal of Stomatology, Oral and Maxillofacial Surgery
https://read.qxmd.com/read/38445546/characterization-of-the-tumor-microenvironment-in-the-mouse-oral-cancer-moc1-model-after-orthotopic-implantation-in-the-buccal-mucosa
#8
JOURNAL ARTICLE
Vikash Kansal, Brendan L C Kinney, Nicole C Schmitt
BACKGROUND: Preclinical models are invaluable for studies of head and neck cancer. There is growing interest in the use of orthotopic syngeneic models, wherein cell lines are injected into the oral cavity of immunocompetent mice. In this brief report, we describe injection of mouse oral cancer 1 (MOC1) cells into the buccal mucosa and illustrate the tumor growth pattern, lymph node response, and changes in the tumor immune microenvironment over time. METHODS: MOC1 cells were injected into the buccal mucosa of C57BL6 mice...
March 6, 2024: Head & Neck
https://read.qxmd.com/read/38443233/a-potential-new-biomarker-in-hnscc-metastasis-suppressor-protein-1-mtss1
#9
JOURNAL ARTICLE
Maurice Klein, Kai Wermker, Ashkan Rashad, Henrike J Fischer, Danny D Jonigk, Frank Hölzle, Claudio Cacchi
OBJECTIVE: Metastasis suppressor protein 1 (MTSS1) is a prognostic tumour marker in different malignant epithelial tumour entities and previously mainly the MTSS1 expression was analysed. This study evaluated the best analysis method as a prognosis and aggressiveness tumour marker in head and neck squamous cell carcinoma (HNSCC). STUDY DESIGN: MTSS1 expression, MTSS1 intensity, interpretation MTSS1 score and MTSS1 edging score were analysed in formalin-fixed paraffin-embedded tissue slices of 60 patients with proven HNSCC and correlated with clinical and pathological outcome parameters...
January 11, 2024: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://read.qxmd.com/read/38441862/use-of-indocyanine-green-near-infrared-imaging-for-sentinel-lymph-node-biopsy-in-early-oral-squamous-cell-carcinoma-a-pilot-study
#10
JOURNAL ARTICLE
Nadja A Stenz, Gregoire B Morand, Manuel Schoch, Jonas Werner, Gunesh P Rajan
PURPOSE: The current established technique for sentinel lymph node (SLN) biopsy is preoperative injection of 99m technetium-labeled nanosized colloids (99m Tc) followed by single photon emission computed tomography and standard computed tomography (SPECT/CT) with subsequent intraoperative gamma probe-guided excision of the SLN. It is however time and resource consuming, causes radiation exposure and morbidity for the patient as the injection is done in the awake patient. Recently near-infrared imaging with indocyanine green (ICG) gained importance in SLN biopsy as a faster and more convenient technique...
March 5, 2024: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://read.qxmd.com/read/38422830/treatment-package-time%C3%A2-%C3%A2-14%C3%A2-weeks-improves-recurrence-free-and-disease-specific-survival-in-hpv-positive-opc-with-high-risk-features
#11
JOURNAL ARTICLE
Manasa Melachuri, Chareeni Kurukulasuriya, Purva Rumde, Terral Patel, Daniel Awad, Seungwon Kim, Robert Ferris, Shaum Sridharan, Umamaheswar Duvvuri
BACKGROUND: Guidelines recommend treatment package time < 85 days and time from surgery to radiation initiation < 6 weeks in head and neck cancer patients. However, HPV positive primaries treated with TORS and adjuvant radiotherapy traditionally demonstrate favorable outcomes. METHODS: Single center retrospective chart review of patients diagnosed with HPV positive treatment naïve primary squamous cell carcinoma treated with TORS and postoperative radiation therapy with or without Chemotherapy from 2012 to 2022 with data collection from December 2022-April 2023...
February 28, 2024: Oral Oncology
https://read.qxmd.com/read/38421075/reliability-and-outcomes-of-lymph-nodes-biopsy-in-ct1-ct2-n0-supraglottic-laryngeal-squamous-cell-carcinoma
#12
JOURNAL ARTICLE
Maryline Hoste, Sébastien Van der Vorst, Georges Lawson, Marie-Cécile Nollevaux, Anne-Sophie Pirson, Vincent Bachy, Olivier Desgain, Samantha Hassid, Gilles Delahaut
BACKGROUND: In oral and oropharyngeal squamous cell carcinoma (SCC), sentinel node biopsy (SNB) was described as a reliable and reproductive alternative to elective neck dissection for the staging of clinical N0 T1-T2 patients. The SNB technique in supraglottic laryngeal SCC was successfully described in small series. The aim of this study is to analyze retrospectively the results of SNB technique in supraglottic SCC in CHU Godinne, to determine if the technique is reliable and may be proposed in a future multicentral prospective trial...
February 29, 2024: Head & Neck
https://read.qxmd.com/read/38419799/oral-squamous-cell-carcinoma-with-synchronous-follicular-lymphoma-a-rare-case-report
#13
Nada Binmadi, Ghidaa Subahi, Maha Alsharif, Yara Daous, Basem Jamal, Hashim Alshinkity, Ahmed Salleh Barefah
The occurrence of oral squamous cell carcinoma synchronously with lymphoma arising primarily in cervical lymph nodes is rare. Here, we report a case representing an infrequent finding. A 66-year-old male who was diagnosed with right mandibular squamous cell carcinoma and was subsequently found to have a nodal follicular lymphoma as a second malignancy. The patient underwent surgical resection for the oral squamous cell carcinoma with right selective neck dissection. The multidisciplinary team's postoperative treatment strategy involved adjuvant radiotherapy for the oral squamous cell carcinoma, while adopting a close follow-up approach for the follicular lymphoma...
2024: SAGE Open Medical Case Reports
https://read.qxmd.com/read/38418701/squamous-cell-carcinoma-of-mandibular-gingiva-producing-both-parathyroid-hormone-related-protein-and-granulocyte-colony-stimulating-factor-a-case-report
#14
JOURNAL ARTICLE
Nobuyuki Kaibuchi, Yuichi Akagi, Chie Kagawa, Chisa Shibayama, Yoko Kawase-Koga, Toshihiro Okamoto
We describe a case of mandibular gingival carcinoma with hypercalcaemia and leukocytosis caused by tumour-derived parathyroid hormone-related protein (PTHrP) and granulocyte colony-stimulating factor (G-CSF). A 54-year-old man presented to our Department of Oral and Maxillofacial Surgery with a chief complaint of a left-sided mandibular gingival ulcer. A 42 mm × 20 mm sized ulcer was found on the left lower molar gingiva. Squamous cell carcinoma was pathologically diagnosed. The patient underwent a hemimandibulectomy, left-sided radical neck dissection, plate reconstruction, pectoralis major musculocutaneous flap reconstruction, and tracheostomy under general anaesthesia...
February 29, 2024: Oral and Maxillofacial Surgery
https://read.qxmd.com/read/38417262/epidemiology-and-management-of-oral-cavity-squamous-cell-carcinoma-in-ireland
#15
JOURNAL ARTICLE
Gerard P Sexton, J M Hintze, Paul Walsh, Frank Moriarty, Paul Lennon, Conall W R Fitzgerald, James Paul O'Neill
INTRODUCTION: The epidemiology and management of oral cavity cancer have changed considerably in recent decades. This study examines epidemiological and management trends in oral cavity squamous cell carcinoma (OCSCC). METHODS: A retrospective cohort study of data from the National Cancer Registry of Ireland between 1994 and 2014. RESULTS: A total of 2725 patients were identified. The most common subsites were the tongue (34 %, n = 1025), lip (19 %, n = 575), floor of mouth (FOM) (18 %, n = 550), and retromolar trigone (RMT) (6 %, n = 189)...
February 23, 2024: American Journal of Otolaryngology
https://read.qxmd.com/read/38391786/predictors-of-occult-metastasis-and-prognostic-factors-in-patients-with-cn0-oral-cancer-who-underwent-elective-neck-dissection
#16
JOURNAL ARTICLE
Kenji Yamagata, Satoshi Fukuzawa, Atsuro Noguchi, Shohei Takaoka, Fumihiko Uchida, Naomi Ishibashi-Kanno, Hiroki Bukawa
Elective neck dissection (END) is recommended for the management of patients with oral squamous cell carcinoma (OSCC) because of the risk of occult metastasis (OM). We hypothesized that some factors predict poor prognosis regardless of a cN0 END. This study aimed to investigate the predictors of OM and prognostic factors in patients with cN0 OSCC who underwent supraomohyoid neck dissection (SOHND). A retrospective cohort study design was created and implemented. The primary predictive variables in this study were OM and risk factors for poor prognosis after SOHND...
February 12, 2024: Diseases (Basel)
https://read.qxmd.com/read/38386236/comparison-of-transoral-vestibular-robotic-thyroidectomy-with-traditional-low-collar-incision-thyroidectomy
#17
JOURNAL ARTICLE
Qing-Qing He, Yun-Han Ma, Jian Zhu, Meng Wang, Gang Wang, Peng Zhou, Dan Wang, Yong-Xiang Liu, Lu-Ming Zheng, Da-Yong Zhuang, Fang Yu, Xian-Jiao Cao, Chang-Rui Liu, Xiao-Lei Li, Tao Yue, Ying-Ying Wang, Hui-Ping Jiang, Yan-Ning Li, Jing Xu
Transoral vestibular robotic thyroidectomy can really make the patient's body surface free of scar. This study aimed to compare the surgical and patient-related outcomes between the transoral vestibular robotic thyroidectomy and traditional low-collar incision thyroidectomy. The clinical data of 120 patients underwent transoral vestibular robotic thyroidectomy (TOVRT) or traditional low-collar incision thyroidectomy (TLCIT) were collected from May 2020 to October 2021. Propensity score matching analysis was used to minimize selection bias...
February 22, 2024: Journal of Robotic Surgery
https://read.qxmd.com/read/38385223/-repairing-partial-suprahyoid-epiglottis-preserved-circumferential-defect-in-near-total-laryngectomy-with-anterior-medial-thigh-flap-in-advanced-laryngeal-cancer
#18
JOURNAL ARTICLE
Liu Yang, Wen Li, Yitao Zheng, Lin Ji
OBJECTIVE: To explore the feasibility to restore pronunciation function by repairing partial suprahyoid epiglottis-preserved circumferential defect in near total laryngectomy with anterior medial thigh flap in advanced laryngeal cancer. METHODS: A retrospective study of 5 male patients with advanced laryngeal cancer between August 2019 and October 2022, aged 56-73 years, with an average age of 65 years were reviewed. The disease duration ranged from 3 to 24 months, with an average of 8 months...
February 15, 2024: Chinese Journal of Reparative and Reconstructive Surgery
https://read.qxmd.com/read/38372707/targeting-dendritic-cell-dysfunction-to-circumvent-anti-pd1-resistance-in-head-and-neck-cancer
#19
JOURNAL ARTICLE
Shin Saito, Michihisa Kono, Hoang C B Nguyen, Ann Marie Egloff, Cameron Messier, Patrick Lizotte, Cloud Paweletz, Douglas Adkins, Ravindra Uppaluri
PURPOSE: Neoadjuvant anti-PD1 (aPD1) therapies are being explored in surgically resectable head and neck squamous cell carcinoma (HNSCC). Encouraging responses have been observed but further insights into the mechanisms underlying resistance and approaches to improve responses are needed. EXPERIMENTAL DESIGN: We integrated data from syngeneic mouse oral carcinoma (MOC) models and neoadjuvant pembrolizumab HNSCC patient tumor RNA-Seq data to explore the mechanism of aPD1 resistance...
February 19, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38365518/contralateral-nodal-relapse-in-well-lateralised-oral-cavity-cancers-treated-uniformly-with-ipsilateral-surgery-and-adjuvant-radiotherapy-with-or-without-concurrent-chemotherapy-a-retrospective-study
#20
JOURNAL ARTICLE
M Swain, A Budrukkar, V Murthy, P Pai, A Kanoja, S Ghosh-Laskar, A Deshmukh, G Pantvaidya, S Kannan, V M Patil, V Naronha, K Prabhash, S Sinha, A Kumar, T Gupta, J Agarwal
AIMS: To evaluate the incidence and pattern of contralateral nodal relapse (CLNR), contralateral nodal relapse-free survival (CLNRFS) and risk factors predicting CLNR in well-lateralised oral cavity cancers (OCC) treated with unilateral surgery and adjuvant ipsilateral radiotherapy with or without concurrent chemotherapy. MATERIALS AND METHODS: Consecutive patients of well-lateralised OCC treated between 2012 and 2017 were included. The primary endpoint was incidence of CLNR and CLNRFS...
February 10, 2024: Clinical Oncology: a Journal of the Royal College of Radiologists
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