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https://www.readbyqxmd.com/read/28328599/burkitt-lymphoma-in-adult-with-atypical-clinical-presentation-primarily-involving-the-oral-soft-tissue
#1
Natália Galvão Garcia, Moacyr Tadeu Vicente Rodrigues, Rodrigo Queiroz Aleixo, Denise Tostes Oliveira
Non-Hodgkin lymphoma is the second most common neoplasm of the head and neck after squamous cell carcinoma. However, it accounts for only 3.5% of all malignancies of the oral cavity. Oral lesions are often a component of disseminated disease process that may involve regional lymph nodes or may at times represent the primary extra nodal form of the disease. Although, isolated oral lymphoma in adults is extremely rare, this paper presents a patient with Burkitt lymphoma in an adult male with atypical clinical presentation primarily involving the oral soft tissue...
March 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28325607/japanese-clinical-practice-guideline-for-head-and-neck-cancer
#2
REVIEW
Ken-Ichi Nibu, Ryuichi Hayashi, Takahiro Asakage, Hiroya Ojiri, Yoshihiro Kimata, Takeshi Kodaira, Toshitaka Nagao, Torahiko Nakashima, Takashi Fujii, Hirofumi Fujii, Akihiro Homma, Kazuto Matsuura, Nobuya Monden, Takeshi Beppu, Nobuhiro Hanai, Tadaaki Kirita, Yuzuru Kamei, Naoki Otsuki, Naomi Kiyota, Sadamoto Zenda, Ken Omura, Koichi Omori, Tetsuo Akimoto, Kazuyoshi Kawabata, Seiji Kishimoto, Hiroya Kitano, Iwai Tohnai, Takashi Nakatsuka
OBJECTIVE: The first revision of "Japanese Clinical Practice Guideline for Head and Neck Cancer" was made in 2013 by the clinical practice guideline committee of Japan Society for Head and Neck Cancer, in response to the revision of the TNM classification. METHODS: 34 CQs (Clinical Questions) were newly adopted to describe the diagnosis and treatment methods currently considered most appropriate, and offered recommendation grade made by the consensus of the committee...
March 18, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28299264/clinical-outcome-of-surgical-treatment-of-t1-2-n0-squamous-cell-carcinoma-of-oral-tongue-with-observation-for-the-neck-analysis-of-176-cases
#3
Arsheed Hussain Hakeem, Sultan Ahmed Pradhan, Rajan Kannan, Jagadish Tubachi
OBJECTIVE: To analyze various demographic, clinical, and histopathologic factors in T1-2 N0 squamous cell carcinoma (SCC) of the oral tongue to define a high-risk group for regional recurrence that will benefit from elective neck dissection. MATERIALS AND METHODS: Retrospective outcome analysis of a patient cohort without palpable or ultrasound (USG) detectable nodal metastases undergoing per oral wide glossectomy for T1-2 N0 SCC of oral tongue. Patients were followed up using palpation and serial USG neck and fine-needle aspiration cytology...
July 2016: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28276113/tumor-volume-as-an-independent-predictive-factor-of-worse-survival-in-patients-with-oral-cavity-squamous-cell-carcinoma
#4
Chin Shien Lin, André Bandiera de Oliveira Santos, Evandro Lima E Silva, Leandro Luongo de Matos, Raquel Ajub Moyses, Marco Aurélio Vamondes Kulcsar, Fábio Roberto Pinto, Lenine Garcia Brandão, Claudio Roberto Cernea
BACKGROUND: The purpose of the present study was to investigate the role of tumor volume in the prognosis of patients with oral cavity squamous cell carcinoma (SCC). METHODS: One hundred twenty-three patients with T4a oral cavity SCCs underwent surgical treatment. The volumes of the primary cancer were calculated by the multiplication of 3 macroscopic dimensions of the surgical specimen and related to recurrence and death. RESULTS: There were 54 recurrences (43...
March 9, 2017: Head & Neck
https://www.readbyqxmd.com/read/28274400/adjuvant-radiation-in-the-tors-era-is-there-a-benefit-to-omitting-the-tumor-bed
#5
Stanislav Lazarev, Blagoja Todorov, James Tam, Vishal Gupta, Brett A Miles, Nancy Lee, Richard L Bakst
PURPOSE: Trans-oral robotic surgery (TORS) followed by adjuvant radiation therapy (RT) is becoming popular in treating node-positive tonsillar squamous cell carcinoma (SCC). One potential benefit is eliminating irradiation of the primary site when the tumor is widely resected, and targeting the neck only. This study assessed whether omitting the tumor bed provides any dosimetric or clinical advantage. METHODS AND MATERIALS: We identified 21 patients with primary tonsillar SCC that were treated with TORS followed by RT to the ipsilateral neck and primary (N+P) site...
March 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28249642/preclinical-upar-targeted-multimodal-imaging-of-locoregional-oral-cancer
#6
M C Boonstra, P B A A Van Driel, S Keereweer, H A J M Prevoo, M A Stammes, V M Baart, C W G M Löwik, A P Mazar, C J H van de Velde, A L Vahrmeijer, C F M Sier
OBJECTIVES: Establishing adequate resection margins and lymphatic mapping are crucial for the prognosis of oral cancer patients. Novel targeted imaging modalities are needed, enabling pre- and intraoperative detection of tumour cells, in combination with improved post-surgical examination by the pathologist. The urokinase-receptor (uPAR) is overexpressed in head and neck cancer, where it is associated with tumour progression and metastasis. MATERIAL AND METHODS: To determine suitability of uPAR for molecular imaging of oral cancer surgery, human head and neck tumours were sectioned and stained for uPAR to evaluate the expression pattern compared to normal mucosa...
March 2017: Oral Oncology
https://www.readbyqxmd.com/read/28249612/do-selective-radiation-dose-escalation-and-tumour-hypoxia-status-impact-the-loco-regional-tumour-control-after-radio-chemotherapy-of-head-neck-tumours-the-escalox-protocol
#7
Steffi U Pigorsch, Jan J Wilkens, Severin Kampfer, Victoria Kehl, Alexander Hapfelmeier, Christian Schläger, Henning Bier, Markus Schwaiger, Stephanie E Combs
BACKGROUND: Standard of care primary treatment of carcinoma of locally advanced squamous cell head and neck cancer (LAHNSCC) consists of platinum-based concomitant chemo-irradiation. Despite progress in the treatment of LAHNSCC using modern radiotherapy techniques the outcome remains still poor. Using IMRT with SIB the escalation of total dose to the GTV is possible with the aim to improve clinical outcome. This study tests the hypothesis if radiation dose escalation to the GTV improves 2-year-LRC and -OS after concomitant chemo-irradiation...
March 1, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28236366/correlating-the-depth-of-invasion-at-specific-anatomic-locations-with-the-risk-for-regional-metastatic-disease-to-lymph-nodes-in-the-neck-for-oral-squamous-cell-carcinoma
#8
Hans C Brockhoff, Roderick Y Kim, Thomas M Braun, Christos Skouteris, Joseph I Helman, Brent B Ward
BACKGROUND: The purpose of this study was to investigate the critical primary tumor depth of invasion in oral squamous cell carcinoma that would lead to a 20% or greater risk of nodal metastasis. METHODS: An institutional review board approved retrospective review of our head and neck database was performed from 2009 to 2014 and the data were statistically analyzed. RESULTS: Two hundred eighty-six patients with a diagnosis of oral squamous cell carcinoma who met our inclusion criteria underwent primary excision and neck dissection...
February 25, 2017: Head & Neck
https://www.readbyqxmd.com/read/28216228/elective-neck-dissection-in-unilateral-carcinomas-of-the-tongue-unilateral-versus-bilateral-approach
#9
Christopher-Philipp Nobis, Sven Otto, Tamara Grigorieva, Mohamed Alnaqbi, Matthias Troeltzsch, Jakob Schöpe, Stefan Wagenpfeil, Michael Ehrenfeld, Klaus-Dietrich Wolff, Marco Rainer Kesting
PURPOSE: Elective neck dissection (END) is a common primary treatment strategy for oral tongue squamous cell carcinoma (OTSCC), although uncertainty remains regarding the necessary extent of END for strictly unilateral early stage OTSCC. The authors evaluated two END variations, unilateral and bilateral, to determine the optimal extent. MATERIALS AND METHODS: A retrospective cohort study was performed on patient data from two departments of oral and maxillofacial surgery...
January 25, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28215944/cd44-cancer-cell-induced-metastasis-a-feasible-neck-metastasis-model
#10
Tian-Fu Wu, Lei Chen, Lin-Lin Bu, Jie Gao, Wen-Feng Zhang, Jun Jia
Neck metastasis of oral squamous cell carcinoma (OSCC) indicates a poor prognosis. Few neck metastasis models are currently available for drug trials and clinical research on OSCC. This study constructed a feasible animal model of neck metastasis by using CD44+ stem cell-like cancer cells. Real-time PCR was used to determine the expression levels of several reported cancer stem cell (CSC) markers, including CD44, CD133, ALDH1 and OCT4, in three OSCC cell lines. Magnetic sorting and DiO/DiD labelling were used to isolate subpopulations of cells and monitor cancer cell migration...
April 1, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28212555/construction-of-a-pathological-risk-model-of-occult-lymph-node-metastases-for-prognostication-by-semi-automated-image-analysis-of-tumor-budding-in-early-stage-oral-squamous-cell-carcinoma
#11
Nicklas Juel Pedersen, David Hebbelstrup Jensen, Giedrius Lelkaitis, Katalin Kiss, Birgitte Charabi, Lena Specht, Christian von Buchwald
It is challenging to identify at diagnosis those patients with early oral squamous cell carcinoma (OSCC), who have a poor prognosis and those that have a high risk of harboring occult lymph node metastases. The aim of this study was to develop a standardized and objective digital scoring method to evaluate the predictive value of tumor budding. We developed a semi-automated image-analysis algorithm, Digital Tumor Bud Count (DTBC), to evaluate tumor budding. The algorithm was tested in 222 consecutive patients with early-stage OSCC and major endpoints were overall (OS) and progression free survival (PFS)...
February 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28209383/expression-pattern-of-heat-shock-protein-90-in-patients-with-oral-squamous-cell-carcinoma-in-northern-taiwan
#12
W-C Chang, P-T Tsai, C-K Lin, Y-S Shieh, Y-W Chen
Heat shock protein 90 (HSP90), which is expressed in cancer cells, profoundly affects progression, invasion, and metastasis. However, to our knowledge, in East Asia, the correlation between the expression of HSP90 and clinicopathological variables has seldom been discussed. We therefore investigated this and its prognostic value in 36 patients newly diagnosed with oral squamous cell carcinoma (SCC) in northern Taiwan. Samples of tumour and normal samples from the patients were compared immunohistochemically...
February 13, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28182650/tropomyosin-1-acts-as-a-potential-tumor-suppressor-in-human-oral-squamous-cell-carcinoma
#13
Hao Pan, Liqun Gu, Binjie Liu, Yiping Li, Yuehong Wang, Xinna Bai, Long Li, Baisheng Wang, Qian Peng, Zhigang Yao, Zhangui Tang
It is widely accepted that oral squamous cell carcinoma (OSCC) is a major contributor to the incidence and mortality of neck and head cancer. Tropomyosin-1 (TPM1), which is expressed at a low level, has been considered a prominent tumor-suppressing gene in a variety of solid tumors, although the precise mechanism of the TPM1 gene in OSCC progression remains unknown. We found that TPM1 expression levels decreased in OSCC patients and OSCC cell lines. The overall and cancer-specific survival of patients who exhibited low TPM1 levels were inferior to those of patients who had high TPM1 levels...
2017: PloS One
https://www.readbyqxmd.com/read/28166075/clinico-histopathological-survey-of-head-and-neck-cancer-at-tertiary-health-care-centre-dhulikhel-hospital
#14
S Dixit, C Upadhyaya, M Humagain, R Srii, V Marla
Background Head and neck is one of the most prevalent site for cancers along with lungs, cervix, breast and stomach. Hospital based cancer registries required for effective evaluation of diagnosis and management of cancer is inadequate in Nepal. Cancer registry system established by WHO is acquired by seven major hospitals in our country. However, data from tertiary health care centres like ours remain undocumented. Objective The objective of this study is to perform retrospective analysis of clinicohistopathological types of head and neck lesions which were eventually diagnosed as cancer in Dhulikel Hospital, a tertiary health care centre of Central East Nepal...
April 2016: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/28157713/the-subclonal-structure-and-genomic-evolution-of-oral-squamous-cell-carcinoma-revealed-by-ultra-deep-sequencing
#15
Siavosh Tabatabaeifar, Mads Thomassen, Martin J Larsen, Stine R Larsen, Torben A Kruse, Jens A Sørensen
Recent studies suggest that head and neck squamous cell carcinomas are very heterogeneous between patients; however the subclonal structure remains unexplored mainly due to studies using only a single biopsy per patient. To deconvolute the clonal structure and describe the genomic cancer evolution, we applied whole-exome sequencing combined with ultra-deep targeted sequencing on oral squamous cell carcinomas (OSCC). From each patient, a set of biopsies was sampled from distinct geographical sites in primary tumor and lymph node metastasis...
February 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28132110/the-added-value-of-spect-ct-for-the-identification-of-sentinel-lymph-nodes-in-early-stage-oral-cancer
#16
Inne J den Toom, Annelies van Schie, Stijn van Weert, K Hakki Karagozoglu, Elisabeth Bloemena, Otto S Hoekstra, Remco de Bree
PURPOSE: To assess the role of single-photon emission computed tomography with computed tomography (SPECT-CT) for the identification of sentinel lymph nodes (SLNs) in patients with early stage (T1-T2) oral cancer and a clinically negative neck (cN0). METHODS: In addition to planar lymphoscintigraphy, SPECT-CT was performed in 66 consecutive patients with early stage oral cancer and a clinically negative neck. The addition of SPECT-CT to planar images was retrospectively analyzed for the number of additional SLNs, more precise localization of SLNs, and importance of anatomical information by a team consisting of a nuclear physician, surgeon, and investigator...
January 29, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28128848/head-and-neck-cancers-major-changes-in-the-american-joint-committee-on-cancer-eighth-edition-cancer-staging-manual
#17
William M Lydiatt, Snehal G Patel, Brian O'Sullivan, Margaret S Brandwein, John A Ridge, Jocelyn C Migliacci, Ashley M Loomis, Jatin P Shah
Answer questions and earn CME/CNE The recently released eighth edition of the American Joint Committee on Cancer (AJCC) Staging Manual, Head and Neck Section, introduces significant modifications from the prior seventh edition. This article details several of the most significant modifications, and the rationale for the revisions, to alert the reader to evolution of the field. The most significant update creates a separate staging algorithm for high-risk human papillomavirus-associated cancer of the oropharynx, distinguishing it from oropharyngeal cancer with other causes...
March 2017: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/28119088/lncrna-tug1-regulates-the-oral-squamous-cell-carcinoma-progression-possibly-via-interacting-with-wnt-%C3%AE-catenin-signaling
#18
Shuang Liang, Songzi Zhang, Peng Wang, Chao Yang, Chen Shang, Jianjun Yang, Jun Wang
Oral squamous cell carcinoma (OSCC) is one the most common cancer affecting the head and neck region, and the molecular mechanisms underlying OSCC development is largely unknown. Long non-coding RNAs (lncRNAs) are emerging as key regulators in tumor development. The present study aimed to investigate the role of lncRNA, taurine upregulated gene 1 (TUG1) in OSCC development. The mRNA and protein expression levels were determined by qRT-PCR and western blotting; flow cytometry and ELISA experiments were employed to examine the cell apoptosis; CCK-8 assay, MTT assay, colony formation assay, and cell invasion assay was used to determine cell growth, cell proliferation and cell invasion, respectively...
April 15, 2017: Gene
https://www.readbyqxmd.com/read/28108239/preoperative-ultrasonography-for-evaluation-of-clinically-n0-neck-in-oral-cavity-carcinoma
#19
Angel Rollon-Mayordomo, Teresa Creo-Martinez, Yolanda Marin-Lapeira, Juan-Andres Rodriguez-Ruiz, Pedro Infante-Cossio
The aim of this study was to evaluate preoperative ultrasound criteria to detect lymph node (LN) cervical metastasis in patients with clinically node-negative neck (cN0) oral cavity squamous cell carcinoma (OCSCC). A prospective, single-center, observational study was conducted in 90 patients undergoing cancer excision with or without elective neck dissection (END) between 2005 and 2012. A surgeon and an experienced radiologist performed preoperative cervical ultrasonography in all cases. The primary objective was to obtain an a priori sensitivity of 90% and specificity >50% in cN0 OCSCC staging...
March 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28107500/diagnostic-efficacy-of-sentinel-lymph-node-biopsy-in-early-oral-squamous-cell-carcinoma-a-meta-analysis-of-66-studies
#20
Muyuan Liu, Steven J Wang, Xihong Yang, Hanwei Peng
OBJECTIVES: The diagnostic efficacy of sentinel lymph node biopsy(SLNB) in early oral squamous cell carcinoma(OSCC) still remains controversial. This meta-analysis was conducted to assess the diagnostic value of SLNB in clinically neck-negative T1-2 OSCC. METHODS: A systematic literature search for relevant literature published up to September 11, 2016 was conducted in PubMed, Embase, Web of Science, Cochrane Library and ClinicalTrials, and the reference lists of eligible studies were examined...
2017: PloS One
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