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Solid pseudopapillary

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https://www.readbyqxmd.com/read/29344231/expression-of-beclin-1-and-bcl-2-in-pancreatic-neoplasms-and-its-effect-on-pancreatic-ductal-adenocarcinoma-prognosis
#1
Shanshan Song, Baosheng Wang, Shuailin Gu, Xiaocheng Li, Shaolong Sun
Aberrant expression of Beclin 1 and B-cell lymphoma-2 (Bcl-2) has been identified in a variety of human tumors; however, little information is available for pancreatic neoplasms. The present study analyzed the expression of Beclin 1 and Bcl-2 in pancreatic ductal adenocarcinoma (PDAC) and solid pseudopapillary neoplasm (SPN) of the pancreas, and evaluated their prognostic significance for PDAC. The present study included 117 PDAC, 43 SPN and 32 chronic pancreatitis (CP) cases. Levels of Beclin 1 and Bcl-2 expression were evaluated semiquantitatively by immunohistochemistry, and their correlation with the survival of patients with PDAC was determined...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29316119/solid-pseudopapillary-tumour-of-the-pancreas-clinicopathological-analysis
#2
Simon McCluney, Nilukshi Wijesuriya, Vinayata Sheshappanavar, Joanne Chin-Aleong, Roger Feakins, Robert Hutchins, Ajit Abraham, Satyajit Bhattacharya, Roberto Valente, Hemant Kocher
BACKGROUND: We report on our experience of the surgical management and outcomes of 11 patients with solid pseudopapillary tumour of the pancreas (SPT). We sought to correlate the immunohistochemical staining of these tumours with that previously reported in the literature. METHODS: A retrospective analysis of the clinical presentation, radiological findings, surgical treatment, histopathological characteristics and outcomes for patients surgically managed with SPT at The Royal London Hospital...
January 8, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29307199/pathologic-classification-of-pancreatic-cancers-current-concepts-and-challenges
#3
Mohamed E Mostafa, Ipek Erbarut-Seven, Burcin Pehlivanoglu, Volkan Adsay
As the most common and most important cancer of the pancreas, with rapid mortality and now also as the third leading cause of cancer-related deaths in the United States, pancreatic ductal adenocarcinoma (PDAC) has become synonymous with "pancreas cancer". PDAC is also the prototype of the "pancreatobiliary-type" adenocarcinomas, along the biliary tract, ampullary and gallbladder cancers with the similar morphology and behavior. Recent molecular profiling studies have identified distinct subsets of PDAC, potentially with different behaviors and targetability...
December 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29290920/extrapancreatic-solid-pseudopapillary-neoplasm-followed-by-multiple-metastases-case-report
#4
Hao Wu, Yan-Fen Huang, Xiang-Hong Liu, Mei-Hua Xu
Solid pseudopapillary neoplasm (SPN), also known as Gruber-Frantz tumor, is a rare form of neoplasm that almost exclusively occurs in the pancreas and in young females. While the potential of malignancy is low for SPN, these tumors can mimic other diseases and require a meticulous investigation and a standard treatment by total surgical resection. We present an unusual case of SPN arising in the mesentery of a 40-year-old man with subsequent multiple metastases. Histopathological examination showed similar properties of the mesenteric neoplasm to those of SPN in pancreas...
December 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29287021/does-computed-tomography-have-the-ability-to-differentiate-aggressive-from-nonaggressive-solid-pseudopapillary-neoplasm
#5
Ashita Rastogi, Mathew Assing, Mellisa Taggart, Brinda Rao, Jia Sun, Khaled Elsayes, Eric Tamm, Priya Bhosale
OBJECTIVE: The aim of the study was to assess the ability of contrast-enhanced computed tomography (CECT) to differentiate aggressive from nonaggressive solid pseudopapillary neoplasms (SPNs). MATERIALS AND METHODS: Forty treatment-naive patients with pathologically proven pancreatic SPNs were included. Imaging characteristics were determined by consensus of 3 radiologists blinded to histopathologic aggressiveness. All patients underwent 4-phase CECT using a pancreatic protocol...
December 28, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/29279599/solid-pseudopapillary-neoplasm-of-the-pancreas-with-liver-metastasis-initially-misinterpreted-as-benign-haemorrhagic-cyst
#6
M J Jung, H K Kim, S Y Choi, S G Kim, S Y Jin
Solid pseudopapillary neoplasm (SPN) of the pancreas is considered a low-malignant neoplasm with a good prognosis. However, 5% to 15% of patients with SPNs develop metastatic disease, most commonly in the liver. Metastatic hepatic malignancies that show pseudocystic features are rare. Here we describe the case of a middle-aged female with a cystic liver metastasis from SPN. To the best of our knowledge, SPN with a single cystic liver metastasis has not been described, although these tumours frequently undergo haemorrhagic-cystic degeneration...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29277262/pancreatectomies-for-pancreatic-neoplasms-in-pediatric-and-adolescent-age-a-single-institution-experience
#7
Chiara Scandavini, Roberto Valente, Elena Rangelova, Ralf Segersvärd, Urban Arnelo, Johan Permert, Pär-Johan Svensson, Jakob Stenman, Marco Del Chiaro
BACKGROUND: There are very few data in the current literature regarding the short- and long-term outcome of surgery for pediatric pancreatic tumors (PPT). No data are available on the impact of pancreatic surgery on the children's growth. METHODS: This is a retrospective cohort study on a consecutive series of pediatric/adolescent patients who underwent pediatric surgery at Karolinska University Hospital from January 2005 to July 2017. RESULTS: Overall 14 pancreatic operations were performed in 13 patients...
December 19, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29275383/solid-pseudopapillary-tumour-frantz-s-tumour-of-the-pancreas-in-childhood-successful-management-of-late-liver-metastases-with-sunitinib-and-chemoembolisation
#8
Mauricio Antonio Escobar, John Mason McClellan, William Thomas
The patient is a girl aged 17 years who originally presented at age 11 years with a solid pseudopapillary tumour (SPT) in the head of the pancreas treated by an R0 pylorus-preserving Whipple procedure. The patient underwent surveillance CT every 3 months for the first year followed by MRI every 6 months. She was noted to have a new liver lesion in Couinaud segment VI highly suspicious for metastasis at 30 months. Liver wedge biopsy confirmed metastatic SPT. Two months later two new lesions were noted in Couinaud segment VII...
December 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29241991/pancreatic-cyst-fluid-glucose-rapid-inexpensive-and-accurate-diagnosis-of-mucinous-pancreatic-cysts
#9
Rosalie A Carr, Michele T Yip-Schneider, Rachel E Simpson, Scott Dolejs, Justine G Schneider, Huangbing Wu, Eugene P Ceppa, Walter Park, C Max Schmidt
BACKGROUND: The most widely accepted biochemical test for preoperative differentiation of mucinous from benign, nonmucinous pancreatic cysts is cyst fluid carcinoembryonic antigen. However, the diagnostic accuracy of carcinoembryonic antigen ranges from 70% to 86%. Based on previous work, we hypothesize that pancreatic cyst fluid glucose may be an attractive alternative to carcinoembryonic antigen. METHODS: Pancreatic cyst fluid was collected during endoscopic or operative intervention...
December 11, 2017: Surgery
https://www.readbyqxmd.com/read/29241452/pancreatic-schwannoma-a-case-report-and-an-updated-40-year-review-of-the-literature-yielding-68-cases
#10
Yuntong Ma, Bingqi Shen, Yingmei Jia, Yanji Luo, Yisu Tian, Zhi Dong, Wei Chen, Zi-Ping Li, Shi-Ting Feng
BACKGROUND: Pancreatic schwannoma is a rare tumor. Preoperative diagnosis of pancreatic schwannoma is challenging due to its tendency to mimic other lesions of the pancreas. We describe a case of pancreatic schwannoma and present a review of the cases currently reported in the English literature to identify characteristics of pancreatic schwannoma on imaging. CASE PRESENTATION: A 53-year-old male presented with a history of intermittent periumbilical abdominal pain and lower back pain for 1 week...
December 14, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29240036/solid-pseudopapillary-neoplasm-of-the-pancreas-in-children-and-adults-a-national-study-of-369-patients
#11
Harold J Leraas, Jina Kim, Zhifei Sun, Brian Ezekian, Brian C Gulack, Christopher R Reed, Elisabeth T Tracy
BACKGROUND: Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare tumor in children, with current evidence limited to single-center studies. We examined treatment and clinical outcomes for pediatric and adult SPN with a national data set. METHODS: The 2004 to 2013 National Cancer Data Base was queried to identify all patients diagnosed with SPN. The cohort was stratified by age (pediatric and adult) defined as below 18 years and 18 years and above, respectively...
December 12, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29212159/lef1-tfe3-and-ar-are-putative-diagnostic-markers-of-solid-pseudopapillary-neoplasms
#12
Eun Kyung Kim, Mi Jang, Minhee Park, Hoguen Kim
The diagnosis of solid pseudopapillary neoplasms (SPNs) is challenging because some SPNs share many similar morphological and immunohistochemical features with other pancreatic neoplasms. In this study, we investigated potential diagnostic markers of SPN. Based on the SPN-specific upregulated genes from a previous DNA microarray and proteome study, we selected six immunohistochemical markers [beta-catenin, androgen receptor (AR), lymphoid enhancer-binding factor 1 (LEF1), transcription factor for immunoglobulin heavy-chain enhancer 3 (TFE3), fused in sarcoma (FUS), and WNT inhibitory factor 1 (WIF-1)]...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29207802/image-findings-of-solid-pseudopapillary-neoplasms-of-the-pancreas-on-multiphasic-multidetector-ct-scan-a-single-institute-experience-from-southern-india
#13
Santosh Rai, Sonali Prabhu, Sharada Rai, Murali Nirupama, Deepa Sa Adiga, Ashvini Kumar, Shrijeet Chakraborti
Introduction: Solid Pseudopapillary Neoplasms (SPN) are uncommon pancreatic tumours and are slow growing with uncertain malignant potential, showing female preponderance. Postoperative prognosis is good and metastasis is rare. Aim: To summarise the imaging and pathological features of seven cases of SPN in three years period, from January 2013 to January 2016. Materials and Methods: In this retrospective study the imaging features of seven cases on triphasic multidetector Computed Tomogram (CT), a 16-slice scanner, were reviewed along with CT-guided Fine Needle Aspiration Cytology (FNAC) and histopathological examination...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29198177/clinicopathologic-features-of-solid-pseudopapillary-pancreatic-neoplasms-in-an-eastern-caribbean-population
#14
Shamir O Cawich, Zulema Ledesma, Lian Sampath, Sherisse Sandy
Pancreatic solid pseudopapillary neoplasms (SPNs) are uncommon lesions across the globe. Their incidence is unknown in the Caribbean. This retrospective study sought to document the clinicopathologic features of pancreatic SPNs in an Eastern Caribbean population. We examined data from the hospital records of all patients with SPN in Trinidad and Tobago, finding 11 cases over five years, equating to an incidence of 0.17 cases per 100,000 population per year. The lesions occurred in girls and young women at a mean age of 25 years, with a propensity for those of Afro-Caribbean descent...
January 1, 2017: Tropical Doctor
https://www.readbyqxmd.com/read/29191273/rare-tumors-and-lesions-of-the-pancreas
#15
REVIEW
John A Stauffer, Horacio J Asbun
There are a few entities that account for most solid and cystic masses of the pancreas. The pancreas harbors a wide array of diseases, including adenocarcinoma, and its variants, such as anaplastic and adenosquamous carcinoma. Other neoplasms include acinar cell carcinoma, solid pseudopapillary tumor, and sarcomas. Benign lesions include hamartomas, hemangiomas, lymphangioma, and plasmacytoma. Isolated metastases include renal cell carcinoma, melanoma, and other carcinomas. Benign inflammatory conditions, such as autoimmune pancreatitis and groove pancreatitis can also mimic solid neoplasms of the pancreas...
February 2018: Surgical Clinics of North America
https://www.readbyqxmd.com/read/29187952/solid-pseudopapillary-neoplasm-of-the-pancreas-in-two-male-patients-gender-does-not-matter
#16
Faten Limaiem, Hafedh Mestiri, Saloua Mejri, Ahlem Lahmar, Sabeh Mzabi
Solid pseudopapillary tumour (SPT) is an unusual pancreatic neoplasm which predominantly affects young women. Less than 10% of patients with SPT in the reported literature were male. In this paper, the authors report two new cases of SPT that occurred in two male patients aged respectively 25 and 20 years old. Abdominal computed tomography scan showed a well-defined heterogeneous mass involving respectively the tail and the body of the pancreas with peripheral calcifications in the first case. The two patients underwent distal splenopancreatectomy...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29153366/papillary-glioneuronal-tumors-a-radiopathologic-correlation
#17
Nishtha Yadav, Shilpa Rao, Jitender Saini, Chandrajit Prasad, Anita Mahadevan, Nishanth Sadashiva
OBJECTIVE: Papillary glioneuronal tumors (PGNT) are a rare and recently recognized tumor entity. The neuroimaging findings were reviewed to determine if any specific findings emerge to assist a preoperative diagnosis of PGNT. MATERIALS AND METHODS: Seven histologically confirmed cases of PGNT were evaluated from 2004 to 2014. Clinical, neuroimaging and histological findings were reviewed and tabulated. RESULTS: Headache and seizures were observed in 4 patients (57...
December 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29149259/pancreatic-cancer-incidence-trends-evidence-from-the-surveillance-epidemiology-and-end-results-seer-population-based-data
#18
Vanessa L Gordon-Dseagu, Susan S Devesa, Michael Goggins, Rachael Stolzenberg-Solomon
Background: Annual pancreatic cancer incidence rates have been increasing. We examine pancreatic cancer incidence trends by demographics and histologic type. Methods: Data from the Surveillance, Epidemiology and End Results (SEER) registries were available to assess temporal trends and pancreatic cancer rates from 1974 to 2013. Results: Pancreatic cancer incidence rates declined between the 1970s and 1990s but increased from 1994 to 2013 among White males...
November 14, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29137016/binding-pancreaticogastrostomy-anastomosis-in-central-pancreatectomy-a-single-center-experience
#19
Pengcheng Kang, Zhidong Wang, Kaiming Leng, Xiangyu Zhong, Hao Wang, Ming Wan, Sheng Tai, Yunfu Cui
A growing number of central pancreatectomies are performed. However, reconstruction of pancreaticoenteral digestive continuity after central pancreatectomy remains debated. This study evaluates the short-term outcomes of binding pancreaticogastrostomy anastomosis in central pancreatectomy.We have reviewed our experience with 52 patients who underwent binding pancreaticogastrostomy following central pancreatectomy from February 2009 to March 2015. Indication includes 6 noninvasive intraductal papillary mucinous neoplasms, 11 neuroendocrine tumors, 12 solid pseudopapillary tumor, 9 serous cystadenoma, 6 mucinous cystadenoma, and 8 focal pancreatic traumas...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29130012/10-year-old-female-with-acute-abdominal-pain-with-pancreatic-mass
#20
Charles K Powers, Molly Posa, Dhanashree Rajderkar, Jaclyn Otero
A previously healthy 10-year-old female presented to a local emergency department following three days of nausea and vomiting diagnosed with a solid pseudopapillary tumor. Solid pseudopapillary neoplasms are a rare form of pancreatic cystic neoplasm that typically presents in young females in their 20-30s and are very rare in children. These neoplasms often present as an asymptomatic tumor found on incidental imaging. When symptomatic they most commonly present with abdominal pain and can also cause a palpable abdominal mass, weight loss, gastrointestinal obstruction, and nausea and vomiting...
2017: Case Reports in Pediatrics
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