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Lin Cheng, BingGuo Wei, Ling Ling He, Ling Mao, Jie Zhang, JinXiang Ceng, DeRong Sun, ChaDan Chen, HanFeng Cui, Nian Hong, Hao Fan
A novel "off-On" electrogenerated chemiluminescence (ECL) biosensor has been developed for the detection of mercury(II) based on molecular recognition technology. The ECL mercury(II) biosensor comprises two main parts: an ECL substrate and an ECL intensity switch. The ECL substrate was made by modifying the complex of Ruthenium(II) tris-(bipyridine)(Ru(bpy)3(2+))/Cyclodextrins-Au nanoparticles(CD-AuNps)/Nafion on the surface of glass carbon electrode (GCE), and the ECL intensity switch is the single hairpin DNA probe designed according to the "molecular recognition" strategy which was functionalized with ferrocene tag at one end and attached to Cyclodextrins (CD) on modified GCE through supramolecular noncovalent interaction...
October 18, 2016: Analytical Biochemistry
Payam Hayati, AliReza Rezvani, Ali Morsali, Pascal Retailleau, Roberto Centore
Nanoparticles of two new 0D, lead(II) coordination supramolecular compounds, [Pb(L)2(I)2] (1) and [Pb(L)(L(/))(H2O)]·3H2O (2), (L=1,10-phenanthroline monohydrate, L(/)=2,6-pyridinedicarboxlic acid), have been synthesized by a sonochemical process and characterized by scanning electron microscopy (SEM), field emission scanning electron microscopy (FE-SEM), X-ray powder diffraction (XRPD), FT-IR spectroscopy and elemental analyses. The single crystal X-ray data of compounds show that the Pb ion is six coordinated in both 1 and 2...
September 7, 2016: Ultrasonics Sonochemistry
Yu Cheng, Srinivasa Rao Avula, Wei-Wei Gao, Dinesh Addla, Vijai Kumar Reddy Tangadanchu, Ling Zhang, Jian-Mei Lin, Cheng-He Zhou
A series of new potentially multi-targeting antimicrobial 2-aminothiazolyl quinolones were designed, synthesized and characterized by (1)H NMR, (13)C NMR, IR, MS and HRMS spectra. Bioactive assay manifested that some of the prepared compounds showed moderate to good antibacterial and antifungal activities. Noticeably, compound 10f could effectively inhibit the growth of B. typhi and MRSA with MIC values of 1 and 8 μg/mL, respectively. Experimental results revealed that compound 10f was membrane-active and had the ability to rapidly kill the tested strains and effectively prevent the development of bacterial resistance...
October 7, 2016: European Journal of Medicinal Chemistry
Giulia Suarato, Seong-Il Lee, Weiyi Li, Sneha Rao, Tanvir Khan, Yizhi Meng, Maya Shelly
During mammalian embryonic development, neurons polarize to create distinct cellular compartments of axon and dendrite that inherently differ in form and function, providing the foundation for directional signaling in the nervous system. Polarization results from spatio-temporal segregation of specific proteins' activities to discrete regions of the neuron to dictate axonal vs. dendritic fate. We aim to manipulate axon formation by directed subcellular localization of crucial intracellular protein function...
October 8, 2016: Biomaterials
Radwan Elzein, Chun-Min Chang, Inna Ponomareva, Wen-Yang Gao, Shengqian Ma, Rudy Schlaf
Metal-organic frameworks (MOFs) deposited from solution have the potential to form 2-dimensional supramolecular thin films suitable for molecular electronic applications. However, the main challenges lie in achieving selective attachment to the substrate surface, and the integration of organic conductive ligands into the MOF structure to achieve conductivity. The presented results demonstrate that photoemission spectroscopy combined with preparation in a system-attached glovebox can be used to characterize the electronic structure of such systems...
October 21, 2016: ACS Applied Materials & Interfaces
Natalia Eliza Domeradzka, Marc W T Werten, Frits A de Wolf, Renko de Vries
Previously, we developed triblock protein polymers that form fibrillar hydrogels at low protein polymer concentrations (denoted C2-SH48-C2). We here demonstrate that the structure of these hydrogels can be tuned via heterodimeric coiled coils that cross-link and bundle the self-assembled protein-polymer fibrils. We fused well-characterized, 47 amino acids-long heterodimeric coiled coil "linkers" (DA or DB) to the C-terminus of the triblock polymer. The resulting C2-SH48-C2-DA and C2-SH48-C2-DB polymers, were successfully produced as secreted proteins in Pichia pastoris, with titers of purified protein in the order of g L-1 of clarified broth...
October 21, 2016: Biomacromolecules
Francesca Bomboi, Flavio Romano, Manuela Leo, Javier Fernandez-Castanon, Roberto Cerbino, Tommaso Bellini, Federico Bordi, Patrizia Filetici, Francesco Sciortino
DNA is acquiring a primary role in material development, self-assembling by design into complex supramolecular aggregates, the building block of a new-materials world. Using DNA nanoconstructs to translate sophisticated theoretical intuitions into experimental realizations by closely matching idealized models of colloidal particles is a much less explored avenue. Here we experimentally show that an appropriate selection of competing interactions enciphered in multiple DNA sequences results into the successful design of a one-pot DNA hydrogel that melts both on heating and on cooling...
October 21, 2016: Nature Communications
Mario Encinar, Santiago Casado, Alicia Calzado-Martín, P Natale, Álvaro San Paulo, Montserrat Calleja, Marisela Vélez, Francisco Monroy, Iván López-Montero
Erythrocyte membranes have been particularly useful as a model for studies of membrane structure and mechanics. Native erythroid membranes can be electroformed as giant unilamellar vesicles (eGUVs). In the presence of ATP, the erythroid membrane proteins of eGUVs rearrange into protein networks at the microscale. Here, we present a detailed nanomechanical study of individual protein microfilaments forming the protein networks of eGUVs when spread on supporting surfaces. Using Peak Force tapping Atomic Force Microscopy (PF-AFM) in liquid environment we have obtained the mechanical maps of the composite lipid-protein networks supported on solid surface...
October 13, 2016: Colloids and Surfaces. B, Biointerfaces
Zhong-Xia Wang, Fen-Ying Kong, Wei Wang
Graphene quantum dots-like structures of highly enriched nitrogen-based dual-color single-functional polymer carbon nanosheets (GLNPCNs) with an average diameter as large as 170 nm (~5 layers) are prepared by a facile hydrothermal method. Intermolecular C5H5N5···C5H5N5 or/and C2H5OH chemical polymerization interactions in the liquid state of the peripheral crown ether-like "hole" decorated compound GLNPCNs lead to a fascinating 2D supramolecular polymer architecture, which exhibits near-ultraviolet (NUV) fluorescence, narrow full width at half maximum, and excellent practical application capability...
October 20, 2016: Chemistry: a European Journal
M Hrubý, S K Filippov, P Štěpánek
Self-organization in a polymer system appears when a balance is achieved between long-range repulsive and short-range attractive forces between the chemically different building blocks. Block copolymers forming supramolecular assemblies in aqueous media represent materials which are extremely useful for the construction of drug delivery systems especially for cancer applications. Such formulations suppress unwanted physicochemical properties of the encapsulated drugs, modify biodistribution of the drugs towards targeted delivery into tissue of interest and allow triggered release of the active cargo...
October 20, 2016: Physiological Research
Eero Kontturi, Anne Meriluoto, Paavo A Penttilä, Niki Baccile, Jani-Markus Malho, Antje Potthast, Thomas Rosenau, Janne Ruokolainen, Ritva Serimaa, Janne Laine, Herbert Sixta
Despite the structural, load-bearing role of cellulose in the plant kingdom, countless efforts have been devoted to degrading this recalcitrant polysaccharide, particularly in the context of biofuels and renewable nanomaterials. Herein, we show how the exposure of plant-based fibers to HCl vapor results in rapid degradation with simultaneous crystallization. Because of the unchanged sample texture and the lack of mass transfer out of the substrate in the gas/solid system, the changes in the crystallinity could be reliably monitored...
October 20, 2016: Angewandte Chemie
Meizhen Yin, Baozhong Lü, Shusen You, Pengyu Li, Chen Li, Klaus Müllen
Supramolecular self-assembly has attracted increasing attention as a breakthrough methodology in the fields of nanoscience and nanotechnology. In this study, a perylene dianhydride derivative (TP-PDA) self-assembles into well-defined nanospheres through a nucleation-growth process. The mechanisms of this process are explored by spectral ananlysis, dynamic light scattering (DLS) and scanning electron microscopy (SEM). Both in-situ DLS and in-situ SEM reveal that the sizes of aggregated nanospheres increase with time until the formation of equilibrium H-aggregates...
October 20, 2016: Chemistry: a European Journal
Florian Hoss, Juan F Rodriguez-Alcazar, Eicke Latz
The inflammasome adapter ASC links activated inflammasome sensors to the effector molecule pro-caspase-1. Recruitment of pro-caspase-1 to ASC promotes the autocatalytic activation of caspase-1, which leads to the release of pro-inflammatory cytokines, such as IL-1β. Upon triggering of inflammasome sensors, ASC assembles into large helical fibrils that interact with each other serving as a supramolecular signaling platform termed the ASC speck. Alternative splicing, post-translational modifications of ASC, as well as interaction with other proteins can perturb ASC function...
October 19, 2016: Cellular and Molecular Life Sciences: CMLS
Christina Wegeberg, Christian Grundahl Frankær, Christine J McKenzie
The iodine L3-edge X-ray Absorption Near Edge Structure (XANES) of organic and inorganic iodine compounds with formal iodine oxidation states ranging from -1 to +7 shows edge energies spanning from 4560.8 eV to 4572.5 eV. These were used to calibrate the oxidation state of iodine in a unique iron complex of iodosylbenzene (PhIO), [Fe(tpena)OIPh](2+) (tpena(-) = N,N,N'-tris(2-pyridylmethyl)ethylenediamine-N'-acetate), which was found to be +1.6. Thus the iodine oxidation state is reduced by 1.4 compared with that in precursor uncoordinated PhIO...
October 20, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Chunfeng Chen, Jie Chen, Tianyu Wang, Minghua Liu
Four kinds of commercially available diacetylene (DA) monomers with different chain length, diacetylene positions were fabricated into the organogels via mixing with a chaperone gelator, an amphiphilic L-histidine ester derivative LHC18 that can help the non-gelator to form gels. Upon photo irradiation with a 254 UV light, the white gels underwent topochemical reaction and turned into red or blue gels, depending on the DA monomer structures. Through the gel formation, the molecular chirality of LHC18 can be transferred to the polydiacetylene (PDA) and helical nanoribbon structures were obtained...
October 19, 2016: ACS Applied Materials & Interfaces
Nobuo Kimizuka, Nobuhiro Yanai, Masa-Aki Morikawa
Self-assembly of functional molecules into ordered molecular assemblies and fulfillment of potentials unique to their nano-to-mesoscopic structures have been one of the central challenges in chemistry. This Feature Article provides an overview of recent progress in the field of molecular self-assembly with the focus on the triplet-triplet annihilation-based photon upconversion (TTA-UC) and supramolecular storage of photon energy. Based on the integration of molecular self-assembly and photon energy harvesting, triplet energy migration-based TTA-UC has been achieved in varied molecular systems...
October 19, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Fengyang Xu, Jie Liu, Jian Tian, Lingfeng Gao, Xiaju Cheng, Yue Pan, Ziling Sun, Xinming Li
In this work, we reported the generation of a novel supramolecular hydrogelator from a peptide derivative which consisted of a structural motif (e.g., Fc-FF) for supramolecular self-assembly and a functional moiety (e.g., RGD) for integrin binding. Following self-assembly in water at neutral pH, this molecule firstly tended to form metastable spherical aggregates, which subsequently underwent a morphological transformation to form high-aspect-ratio nanostructures over 2 h when aged at room temperature. More importantly, because of the presence of nanoscale RGD clusters on the surface of nanostructures, the self-assembled nanomaterials (e...
October 19, 2016: ACS Applied Materials & Interfaces
Lei Zhang, Theresa Chimamkpam, Camelia I Onet, Nianyong Zhu, Rodolphe Clérac, Wolfgang Schmitt
We report a supramolecular approach to mixed-valent Mn coordination clusters that demonstrates how halide ions can be applied to influence the assembly of distinct tetranuclear building units to produce a number of related Mn coordination clusters with dense core structures that derive from a cuboctahedral arrangement of Mn ions. In all compounds the alignment of the Jahn-Teller axes of the Mn(III) centers coincides with the positions of the stabilizing chloride ligands. Thus, the relative chloride concentrations in the reaction mixtures allow us to modify the symmetry and magnetic anisotropy of this basic core structures resulting in isotropic polynuclear high-spin complexes at high Cl(-) concentrations and Single-Molecule Magnets at lower relative Cl(-) concentrations...
October 19, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Katsuaki Hirano, Masahiro Kurosaki, Satoshi Nihei, Hiroki Hasegawa, Suguru Shinoda, Mitsuru Haruki, Nobutaka Hirano
The cellulosome is a supramolecular multienzyme complex comprised of a wide variety of polysaccharide-degrading enzymes and scaffold proteins. The cellulosomal enzymes that bind to the scaffold proteins synergistically degrade crystalline cellulose. Here, we report in vitro reconstitution of the Clostridium thermocellum cellulosome from 40 cellulosomal components and the full-length scaffoldin protein that binds to nine enzyme molecules. These components were each synthesized using a wheat germ cell-free protein synthesis system and purified...
October 19, 2016: Scientific Reports
Dipankar Sahoo, Mihai Peterca, Emad Aqad, Benjamin E Partridge, Paul A Heiney, Robert Graf, Hans W Spiess, Xiangbing Zeng, Virgil Percec
Perylene bisimide derivatives (PBIs) are known to form only columnar or lamellar assemblies. There is no known example of a PBI self-assembling into a supramolecular sphere. Therefore, periodic and quasiperiodic arrays generated from spherical assemblies produced from PBIs are also not known. Here, a PBI functionalized at its imide groups with a second generation self-assembling dendron is reported to self-assemble into supramolecular spheres. These spheres self-organize in a body-centered cubic (BCC) periodic array, rarely encountered for self-assembling dendrons but often encountered in block copolymers...
October 19, 2016: Journal of the American Chemical Society
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