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https://www.readbyqxmd.com/read/28535062/supramolecular-hydrogel-formation-in-a-series-of-self-assembling-lipopeptides-with-varying-lipid-chain-length
#1
Valeria Castelletto, Amanpreet Kaur, Radoslaw M Kowalczyk, Ian W Hamley, Mehedi Reza, Janne Ruokolainen
The self-assembly in aqueous solution of three lipopeptides comprising a bioactive motif conjugated at the N terminus to dodecyl, tetradecyl or hexadecyl lipid chains has been examined. The bioactive motif is the peptide block YEALRVANEVTLN; a C-terminal fragment of the lumican proteoglycan. This study was motivated by our previous studies on the hexadecyl homologue C16-YEALRVANEVTLN which showed aggregation into β-sheet structures above a critical aggregation concentration (cac), but most remarkably we found that these aggregates were stable to dilution below the cac...
May 23, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28533751/docetaxel-loaded-nanoparticles-assembled-from-%C3%AE-cyclodextrin-calixarene-giant-surfactants-physicochemical-properties-and-cytotoxic-effect-in-prostate-cancer-and-glioblastoma-cells
#2
Laura Gallego-Yerga, Inmaculada Posadas, Cristina de la Torre, Jesús Ruiz-Almansa, Francesco Sansone, Carmen Ortiz Mellet, Alessandro Casnati, José M García Fernández, Valentín Ceña
Giant amphiphiles encompassing a hydrophilic β-cyclodextrin (βCD) component and a hydrophobic calix[4]arene (CA4) module undergo self-assembly in aqueous media to afford core-shell nanospheres or nanocapsules, depending on the nanoprecipitation protocol, with high docetaxel (DTX) loading capacity. The blank and loaded nanoparticles have been fully characterized by dynamic light scattering (DLS), ζ-potential measurements and cryo-transmission electron microscopy (cryo-TEM). The data are compatible with the distribution of the drug between the nanoparticle core and the shell, where it is probably anchored by inclusion of the DTX aromatic moieties in βCD cavities...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28532152/attractive-interactions-between-heteroallenes-and-the-cucurbituril-portal
#3
Ofer Reany, Amanda Li, Maayan Yefet, Michael K Gilson, Ehud Keinan
This study reports on the remarkable attractive interaction between organic azides and the portal carbonyls of cucurbiturils. Five homologous bis-α,ω-azidoethylammonium alkanes were prepared, where the number of methylene groups between the ammonium groups ranges from 4 to 8. Their interactions with cucurbit[6]uril were studied by NMR, IR and X-ray crystallography, and by computational methods. Remarkably, while the distance between the portal plane and most atoms at the guest end groups increase progressively with the molecular size, the β-nitrogen atoms maintain a constant distance from the portal plane in all homologs, pointing at a strong attractive interaction between the azide group and the portal...
May 23, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28531977/antibiofilm-effect-of-supramolecularly-templated-mesoporous-silica-coatings
#4
Magdalena Pezzoni, Paolo N Catalano, Ramón A Pizarro, Martín F Desimone, Galo J A A Soler-Illia, Martín G Bellino, Cristina S Costa
Bacteria attached to solid surfaces and encased in a self-synthesized matrix, so-called biofilms, are highly difficult to eradicate and present negative impact on industry and human health. The ability of supramolecularly templated mesoporous silica coatings to inhibit biofilm formation in Pseudomonas aeruginosa is shown here. Assays employing submerged and air-liquid interface biofilms demonstrated that mesoporous coatings with tuned pore size significantly reduce the number of attached bacteria and matrix production...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28530792/phosphonated-pillar-5-arene-valved-mesoporous-silica-drug-deliv-ery-systems
#5
Xuan Huang, Shanshan Wu, Xiaokang Ke, Xueyuan Li, Xuezhong Du
To explore the diversity and promising applications of pillararene-based molecular machines, phosphonated pillar[5]arenes (PPA[5]) were synthesized to construct novel supramolecular nanovalves for the first time, based on mesoporous silica nanoparticles (MSNs) functionalized with choline and pyridinium moieties, respectively. PPA[5] encircled the choline or pyridinium stalks to construct supramolecular nanovalves for encapsulation of drugs within the MSN pores. PPA[5] showed a high binding affinity for the quaternary ammonium stalks through the host-guest interactions primarily via ion pairing between the phosphonate and quaternary ammonium moieties, in comparison to carboxylated pillar[5]arene (CPA[5]), to minimize premature drug release...
May 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28530727/temperature-induced-reversible-single-crystal-to-single-crystal-isomerisation-of-uranyl-polyrotaxanes-an-exquisite-case-of-coordination-variability-of-the-uranyl-center
#6
Zhen-Ni Xie, Lei Mei, Qun-Yan Wu, Kong-Qiu Hu, Liang-Shu Xia, Zhi-Fang Chai, Wei-Qun Shi
The first reversible solid-state single-crystal-to-single-crystal isomerisation mediated by the change of uranyl-ligand coordination modes, that is from seven-coordinated uranium(vi) of α-UP to six-coordinated uranium(vi) of the supramolecular isomer, β-UP, has been achieved in the uranyl polyrotaxane system by a temperature-induced strategy.
May 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28530665/molecular-engineering-of-chiral-colloidal-liquid-crystals-using-dna-origami
#7
Mahsa Siavashpouri, Christian H Wachauf, Mark J Zakhary, Florian Praetorius, Hendrik Dietz, Zvonimir Dogic
Establishing precise control over the shape and the interactions of the microscopic building blocks is essential for design of macroscopic soft materials with novel structural, optical and mechanical properties. Here, we demonstrate robust assembly of DNA origami filaments into cholesteric liquid crystals, one-dimensional supramolecular twisted ribbons and two-dimensional colloidal membranes. The exquisite control afforded by the DNA origami technology establishes a quantitative relationship between the microscopic filament structure and the macroscopic cholesteric pitch...
May 22, 2017: Nature Materials
https://www.readbyqxmd.com/read/28530247/long-range-ferrimagnetic-order-in-a-two-dimensional-supramolecular-kondo-lattice
#8
Jan Girovsky, Jan Nowakowski, Md Ehesan Ali, Milos Baljozovic, Harald R Rossmann, Thomas Nijs, Elise A Aeby, Sylwia Nowakowska, Dorota Siewert, Gitika Srivastava, Christian Wäckerlin, Jan Dreiser, Silvio Decurtins, Shi-Xia Liu, Peter M Oppeneer, Thomas A Jung, Nirmalya Ballav
Realization of long-range magnetic order in surface-supported two-dimensional systems has been challenging, mainly due to the competition between fundamental magnetic interactions as the short-range Kondo effect and spin-stabilizing magnetic exchange interactions. Spin-bearing molecules on conducting substrates represent a rich platform to investigate the interplay of these fundamental magnetic interactions. Here we demonstrate the direct observation of long-range ferrimagnetic order emerging in a two-dimensional supramolecular Kondo lattice...
May 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28529382/reversibly-manipulating-the-surface-chemistry-of-polymeric-nanostructures-via-a-grafting-to-approach-mediated-by-nucleobase-interactions
#9
Zan Hua, Robert Keogh, Zhen Li, Thomas R Wilks, Guosong Chen, Rachel K O'Reilly
"Grafting to" polymeric nanostructures or surfaces is a simple and versatile approach to achieve functionalization. Herein, we describe the formation of mixed polymer-grafted nanoparticles through a supramolecular "grafting to" method that exploits multiple hydrogen-bonding interactions between the thymine (T)-containing cores of preformed micelles and the complementary nucleobase adenine (A) of added diblock copolymers. To demonstrate this new "grafting to" approach, mixed-corona polymeric nanoparticles with different sizes were prepared by the addition of a series of complementary diblock copolymers containing thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) to a preformed micelle with a different coronal forming block, poly(4-acryloylmorpholine) (PNAM)...
May 9, 2017: Macromolecules
https://www.readbyqxmd.com/read/28528552/universal-selective-dispersion-of-semiconducting-carbon-nanotubes-from-commercial-sources-using-a-supramolecular-polymer
#10
Alex Chortos, Igor Pochorovski, Pei Lin, Gregory Pitner, Xuzhou Yan, Theodore Z Gao, John W F To, Ting Lei, John W Will, H-S Philip Wong, Zhenan Bao
Selective extraction of semiconducting carbon nanotubes is a key step in the production of high-performance, solution-processed electronics. Here we describe the ability of a supramolecular sorting polymer to selectively disperse semiconducting carbon nanotubes from five commercial sources with diameters ranging from 0.7 nm to 2.2 nm. The sorting purity of the largest diameter nanotubes (1.4 nm to 2.2 nm; from Tuball) was confirmed by short channel measurements to be 97.5%. Removing the sorting polymer by acid-induced disassembly increased the transistor mobility by 94% and 24% for medium-diameter and large-diameter carbon nanotubes, respectively...
May 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/28527428/physicochemical-and-biological-interactions-between-cerium-oxide-nanoparticles-and-a-1-8-naphthalimide-derivative
#11
Gerardo Pulido-Reyes, Esperanza Martín, J L Gu Coronado, Francisco Leganes, Roberto Rosal, Francisca Fernández-Piñas
Cerium (Ce) oxide nanoparticles (CNPs) have attracted attention due to their high bioactivity and unique redox-chemistry. The oxygen vacancies at the surface of the nanoparticle explain the autocatalytic properties of CNPs in which the Ce(3+) atoms occupy the center of the oxygen vacancies surrounded by Ce(4+) atoms. Until now, CNPs have been associated with organic molecules at the synthesis stage to extend their applications or improve their stability. However, there is a lack of information regarding the post-synthesis interaction of CNPs and organic molecules that could enhance or induce new properties...
May 10, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28526935/diabetes-induced-abnormalities-of-mitochondrial-function-in-rat-brain-cortex-the-effect-of-n-3-fatty-acid-diet
#12
Maria Chomova, Maria Balazova, Jana Muchova
Diabetic encephalopathy, a proven complication of diabetes is associated with gradually developing end-organ damage in the CNS increasing the risk of stroke, cognitive dysfunction or Alzheimer's disease. This study investigated the response of rat cortical mitochondria to streptozotocin-induced diabetes and the potential for fish oil emulsion (FOE) to modulate mitochondrial function. Diabetes-induced deregulation of the respiratory chain function as a result of diminished complex I activity (CI) and cytochrome c oxidase hyperactivity was associated with attenuation of antioxidant defense of isolated cortical mitochondria, monitored by SOD activity, the thiol content, the dityrosine and protein-lipid peroxidation adduct formation...
May 19, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28524876/self-assembly-of-a-supramolecular-hexagram-and-a-supramolecular-pentagram
#13
Zhilong Jiang, Yiming Li, Ming Wang, Bo Song, Kun Wang, Mingyu Sun, Die Liu, Xiaohong Li, Jie Yuan, Mingzhao Chen, Yuan Guo, Xiaoyu Yang, Tong Zhang, Charles N Moorefield, George R Newkome, Bingqian Xu, Xiaopeng Li, Pingshan Wang
Five- and six-pointed star structures occur frequently in nature as flowers, snow-flakes, leaves and so on. These star-shaped patterns are also frequently used in both functional and artistic man-made architectures. Here following a stepwise synthesis and self-assembly approach, pentagonal and hexagonal metallosupramolecules possessing star-shaped motifs were prepared based on the careful design of metallo-organic ligands (MOLs). In the MOL design and preparation, robust ruthenium-terpyridyl complexes were employed to construct brominated metallo-organic intermediates, followed by a Suzuki coupling reaction to achieve the required ensemble...
May 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28524850/a-high-quantum-yield-molecule-protein-complex-fluorophore-for-near-infrared-ii-imaging
#14
Alexander L Antaris, Hao Chen, Shuo Diao, Zhuoran Ma, Zhe Zhang, Shoujun Zhu, Joy Wang, Alexander X Lozano, Quli Fan, Leila Chew, Mark Zhu, Kai Cheng, Xuechuan Hong, Hongjie Dai, Zhen Cheng
Fluorescence imaging in the second near-infrared window (NIR-II) allows visualization of deep anatomical features with an unprecedented degree of clarity. NIR-II fluorophores draw from a broad spectrum of materials spanning semiconducting nanomaterials to organic molecular dyes, yet unfortunately all water-soluble organic molecules with >1,000 nm emission suffer from low quantum yields that have limited temporal resolution and penetration depth. Here, we report tailoring the supramolecular assemblies of protein complexes with a sulfonated NIR-II organic dye (CH-4T) to produce a brilliant 110-fold increase in fluorescence, resulting in the highest quantum yield molecular fluorophore thus far...
May 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28524354/an-aggregating-amphiphilic-squaraine-a-light-up-probe-that-discriminates-parallel-g-quadruplexes
#15
Vincenzo Grande, Filippo Doria, Mauro Freccero, Frank Würthner
G-quadruplexes (G4s) are peculiar DNA or RNA tertiary structures that are involved in the regulation of many biological events within mammalian cells, bacteria, and viruses. Although their role as versatile therapeutic targets has been emphasized for 35 years, G4 selectivity over ubiquitous double-stranded DNA/RNA, as well as G4 differentiation by small molecules, still remains challenging. Here, a new amphiphilic dicyanovinyl-substituted squaraine, SQgl, is reported to act as an NIR fluorescent light-up probe discriminating an extensive panel of parallel G4s while it is non-fluorescent in the aggregated state...
May 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28524265/a-highly-sensitive-resonance-rayleigh-scattering-and-colorimetric-assay-for-the-recognition-of-propranolol-in-%C3%AE-adrenergic-blocker
#16
Xuanping Tan, Jidong Yang, Qiong Yang, Qin Li
In this work, a highly sensitive, citrate anion-capped gold nanoparticles (AuNPs)-based assay for the determination of propranolol in real samples with resonance Rayleigh scattering (RRS) and colorimetry was developed. When AuNPs were prepared by the sodium citrate reduction method, citrate anions self-assembled on the surface of AuNPs to form supramolecular complex anions. In BR 4.6 buffer solution, propranolol was positively charged and could bind with AuNPs to form larger aggregates through electrostatic force and hydrophobic effects...
May 19, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28524194/chiral-supramolecular-organization-from-a-sheet-like-achiral-gel-a-study-of-chiral-photoinduction
#17
Jorge Royes, Víctor Polo, Santiago Uriel, Luis Oriol, Milagros Piñol, Rosa M Tejedor
Chiral photoinduction in a photoresponsive gel based on an achiral 2D architecture with high geometric anisotropy and low roughness has been investigated. Circularly polarized light (CPL) was used as a chiral source and an azobenzene chromophore was employed as a chiral trigger. The chiral photoinduction was studied by evaluating the preferential excitation of enantiomeric conformers of the azobenzene units. Crystallographic data and density functional theory (DFT) calculations show how chirality is transferred to the achiral azomaterials as a result of the combination of chiral photochemistry and supramolecular interactions...
May 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28524069/helical-plant-viral-nanoparticles-bioinspired-synthesis-of-nanomaterials-and-nanostructures
#18
Kannan Badri Narayanan, Sung Soo Han
Viral nanotechnology is revolutionizing the biomimetic and bioinspired synthesis of novel nanomaterials. Bottom-up nanofabrication by self-assembly of individual molecular components of elongated viral nanoparticles (VNPs) and virus-like particles (VLPs) has resulted in the production of superior materials and structures in the nano(bio)technological fields. Viral capsids are attractive materials, because of their symmetry, monodispersity, and polyvalency. Helical VNPs/VLPs are unique prefabricated nanoscaffolds with large surface area to volume ratios and high aspect ratios, and enable the construction of exquisite supramolecular nanostructures...
May 19, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/28523914/polymerizable-supramolecular-approach-to-highly-conductive-pedot-pss-patterns
#19
Taegeun Kim, Suryong Ha, Hyosung Choi, Kyungchan Uh, Umesha Kundapur, Sumin Park, Chan Woo Lee, Sang-Hwa Lee, Jaeyong Kim, Jong-Man Kim
Owing to its high conductivity, solution processability, mechanical flexibility and transparency, poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) has been extensively explored for use in functional devices including solar cells, sensors, light emitting diodes and supercapacitors. The ability to fabricate patterned PEDOT:PSS on a solid substrate is of significant importance in order to develop practical applications of this conducting polymer. Herein we describe a new approach to obtain PEDOT:PSS patterns that is based on a polymerizable supramolecular concept...
May 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28523825/biphasic-supramolecular-self-assembly-of-ferric-ions-and-tannic-acid-across-interfaces-for-nanofilm-formation
#20
Beom Jin Kim, Sol Han, Kyung-Bok Lee, Insung S Choi
Cell nanoencapsulation provides a chemical tool for the isolation and protection of living cells from harmful, and often lethal, external environments. Although several strategies are available to form nanometric films, most methods heavily rely on time-consuming multistep processes and are not biocompatible. Here, the interfacial supramolecular self-assembly and film formation of ferric ions (Fe(III) ) and tannic acid (TA) in biphasic systems is reported, where Fe(III) and TA come into contact each other and self-assemble across the interface of two immiscible phases...
May 19, 2017: Advanced Materials
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