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https://www.readbyqxmd.com/read/29143802/the-inhibitory-effects-of-cobalt-protoporphyrin-ix-and-cannabinoid-2-receptor-agonists-in-type-2-diabetic-mice
#1
Christina McDonnell, Sergi Leánez, Olga Pol
The activation of the transcription factor Nrf2 inhibits neuropathy and modulates the activity of delta-opioid receptors (DOR) in type 2 diabetic mice but the impact of Nrf2/HO-1 pathway on the antinociceptive actions of cannabinoid 2 receptors (CB2R) has not been assessed. Using male mice BKS.Cg-m+/+Leprdb/J (db/db) we investigated if treatment with cobalt protoporphyrin IX (CoPP), an HO-1 inductor, inhibited mechanical allodynia, hyperglycemia and obesity associated to type 2 diabetes. The antinociceptive effects of JWH-015 and JWH-133 (CB2R agonists) administered with and without CoPP or sulforaphane (SFN), a Nrf2 transcription factor activator, have been also evaluated...
October 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29139225/oolong-tea-prevents-cardiomyocyte-loss-against-hypoxia-by-attenuating-p-jnk-mediated-hypertrophy-and-enhancing-p-igf1r-p-akt-and-p-bad-ser136-activity-and-by-fortifying-nrf2-antioxidation-system
#2
Marthandam Asokan Shibu, Chia-Hua Kuo, Bih-Cheng Chen, Da-Tong Ju, Ray-Jade Chen, Chao-Hung Lai, Pei-Jane Huang, Vijaya Padma Viswanadha, Wei-Wen Kuo, Chih-Yang Huang
Tea, the most widely consumed natural beverage has been associated with reduced mortality risk from cardiovascular disease. Oolong tea is a partially fermented tea containing high levels of catechins, their degree of oxidation varies between 20%-80% causing differences in their active metabolites. In this study we examined the effect of oolong tea extract (OTE) obtained by oxidation at low-temperature for short-time against hypoxic injury and found that oolong tea provides cyto-protective effects by suppressing the JNK mediated hypertrophic effects and by enhancing the innate antioxidant mechanisms in neonatal cardiomyocytes and in H9c2 cells...
November 15, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29138498/glutaredoxin-1-mediates-the-protective-effect-of-steady-laminar-flow-on-endothelial-cells-against-oxidative-stress-induced-apoptosis-via-inhibiting-bim
#3
Yao Li, Meng Ren, Xiaoqun Wang, Xingxing Cui, Hongmei Zhao, Chuanrong Zhao, Jing Zhou, Yanan Guo, Yi Hu, Chen Yan, Bradford Berk, Jing Wang
Endothelial cell apoptosis induced by oxidative stress is an early event in the development of atherosclerosis. Several antioxidant enzymes which can cope with oxidative stress are up-regulated by the anti-atherogenic laminar blood flow often seen in straight or unbranched regions of blood vessels. However, the molecular mechanism responsible for flow-induced beneficial effects is incompletely understood. Here we report the role of glutaredoxin 1 (Grx1), an antioxidant enzyme, in flow-mediated protective effect in endothelial cells...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29130959/ginsenoside-rg1-protects-cardiomyocytes-against-hypoxia-reoxygenation-injury-via-activation-of-nrf2-ho-1-signaling-and-inhibition-of-jnk
#4
Qianhui Li, Yin Xiang, Yu Chen, Yong Tang, Yachen Zhang
BACKGROUND/AIMS: Excessive reactive oxygen species (ROS) disturb the physiology of H9c2 cells, which is regarded as a major cause of H9c2 cardiomyocyte apoptosis. Ginsenoside Rg1 is the main active extract of ginseng, which has important antioxidant properties in various cell models. This project investigated the role of ginsenoside Rg1 in hypoxia/reoxygenation (H/R)-induced oxidative stress injury in cultured H9c2 cells to reveal the underlying signaling pathways. METHODS: H9c2 cells were pretreated with ginsenoside Rg1 for 12 h before exposure to H/R...
November 3, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29119451/pristimerin-inhibits-lps-triggered-neurotoxicity-in-bv-2-microglia-cells-through-modulating-irak1-traf6-tak1-mediated-nf-%C3%AE%C2%BAb-and-ap-1-signaling-pathways-in-vitro
#5
Bin Hui, Liping Zhang, Qinhua Zhou, Ling Hui
Microglia plays a prominent role in the brain's inflammatory response to injury or infection by migrating to affected locations and secreting inflammatory molecules. However, hyperactivated microglial is neurotoxic and plays critical roles in the pathogenesis of neurodegenerative diseases. Pristimerin, a naturally occurring triterpenoid, possesses antitumor, antioxidant, and anti-inflammatory activities. However, the effect and the molecular mechanism of pristimerin against lipopolysaccharide (LPS)-induced neurotoxicity in microglia remain to be revealed...
November 8, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/29117537/antioxidant-effects-of-epigallocatechin-3-gallate-on-the-atc1-6-pancreatic-alpha-cell-line
#6
Ting Cao, Xiong Zhang, Dan Yang, Yue-Qian Wang, Zheng-Dong Qiao, Jian-Ming Huang, Peng Zhang
Hypoglycemia is a major barrier to achieving stable metabolic control in patients with diabetes which is a serious clinical concern. With progression of diabetes, the ability of pancreatic α-cells which respond to hypoglycemia becomes impaired; However, it is not clear whether the dysfunctional responses of α-cells during hypoglycemia are related with oxidative stress. In the present study, we investigated whether epigallocatechin-3-gallate (EGCG) has antioxidant potential on pancreatic alpha TC1-6 (αTC1-6) cell lines and protect the normal function of α-cells from H2O2 induced oxidative stress...
November 5, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29115625/protective-effects-of-silymarin-on-triptolide-induced-acute-hepatotoxicity-in-rats
#7
Lan Wang, Qiong-Hui Huang, Yong-Xian Li, Yan-Feng Huang, Jian-Hui Xie, Lie-Qiang Xu, Yao-Xing Dou, Zi-Ren Su, Hui-Fang Zeng, Jian-Nan Chen
Silymarin has been used in the treatment of a number of liver diseases for a long time, but its efficacy in preventing triptolide induced acute hepatotoxicity has not been reported previously. The present study aimed to assess the protective effect of silymarin against triptolide (TP)-induced hepatotoxicity in rats. Rats were orally administrated with silymarin (50, 100 and 200 mg/kg) for 7 days and received intraperitoneal TP (2 mg/kg) on the day 8. Hepatic injuries were comprehensively evaluated in terms of serum parameters, morphological changes, oxidative damage, inflammation and apoptosis...
November 3, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29115390/anti-hypoglycemic-and-hepatocyte-protective-effects-of-hyperoside-from-zanthoxylum-bungeanum-leaves-in-mice-with-high-carbohydrate-high-fat-diet-and-alloxan-induced-diabetes
#8
Yali Zhang, Mimi Wang, Huanhuan Dong, Xiaomin Yu, Jingfang Zhang
The development of diabetes mellitus (DM) is accompanied by hyperglycemia-induced oxidative stress. Hyperoside is a major bioactive component in Zanthoxylum bungeanum leaves (HZL) and is a natural antioxidant. However, the effects of HZL on DM and its mechanisms of action remain undefined. The present study evaluated the anti-hypoglycemic and hepatocyte-protective effects of HZL in mice with diabetes induced by a high-carbohydrate/high-fat diet (HFD) and alloxan. We also aimed to eludicate the underlying mechanisms...
October 25, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29093682/salidroside-a-natural-antioxidant-improves-%C3%AE-cell-survival-and-function-via-activating-ampk-pathway
#9
Linjie Ju, Xiaohua Wen, Chunjun Wang, Yingjie Wei, Yunru Peng, Yongfang Ding, Liang Feng, Luan Shu
Aim: The enhanced oxidative stress contributes to progression of type 2 diabetes mellitus (T2DM) and induces β-cell failure. Salidroside is a natural antioxidant extracted from medicinal food plant Rhodiola rosea. This study was aimed to evaluate protective effects of salidroside on β-cells against diabetes associated oxidative stress. Methods and Results: In diabetic db/db and high-fat diet-induced mice, we found salidroside ameliorated hyperglycemia and relieved oxidative stress. More importantly, salidroside increased β-cell mass and β-cell replication of diabetic mice...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29078725/cardioprotective-effects-of-rutin-in-rats-exposed-to-pirarubicin-toxicity
#10
Ya-Di Wang, Yang Zhang, Bo Sun, Xiao-Wei Leng, Ya-Juan Li, Li-Qun Ren
We established both an acute and chronic cardiac toxicity rat model, which showed pretreatment with rutin attenuated pirarubicin-induced myocardial histopathological injury, electrocardiogram abnormalities, and cardiac dysfunction. Rutin also significantly reduced serum levels of MDA, BNP, CK-MB, CTnT, and LDH and increased serum SOD levels. Treatment with rutin and dexrazoxane resulted in an increase in Bcl-2/Bax ratio (p < 0.05) and reduction in JNK and Caspase-3 protein levels, compared to the pirarubicin group (all p < 0...
October 27, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29073777/neuroprotective-effects-of-orientin-on-oxygen-glucose-deprivation-reperfusion-induced-cell-injury-in-primary-culture-of-rat-cortical-neurons
#11
Tian Tian, Junan Zeng, Guangyu Zhao, Wenjing Zhao, Songyi Gao, Li Liu
Orientin (luteolin-8-C-glucoside) is a phenolic compound found abundantly in millet, juice, and peel of passion fruit and has been shown to have antioxidant properties. In the present study, we explored the effects of orientin on oxygen-glucose deprivation/reperfusion (OGD/RP)-induced cell injury in primary culture of rat cortical neurons using an in vitro model of neonatal ischemic brain injury. The reduced cell viability and elevated lactate dehydrogenase leakage were observed after OGD/RP exposure, which were then reversed by orientin (10, 20, and 30 µM) pretreatment in a dose-dependent manner...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29040306/micheliolide-suppresses-lps-induced-neuroinflammatory-responses
#12
Zhaomeng Sun, Guodong Li, Tanjun Tong, Jun Chen
Microglia-involved neuroinflammation is thought to promote brain damage in various neurodegenerative disorders. Thus, inhibition of microglial over-activation may have a therapeutic benefit for the treatment of neurodegenerative disorders. Micheliolide (MCL) is a sesquiterpene lactone which inhibits various inflammatory response. However, whether MCL can inhibit neuroinflammation caused by LPS-activated BV2 microglia has not yet been explored. In this study, we demonstrated that treatment of BV2 cells with MCL significantly repressed LPS-stimulated nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression, as well as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and nitric oxide (NO) induction...
2017: PloS One
https://www.readbyqxmd.com/read/29039568/3-3-%C3%A2-diindolylmethane-attenuates-cardiomyocyte-hypoxia-by-modulating-autophagy-in-h9c2-cells
#13
Kai Liang, Wen-Hao Qian, Jing Zong
Autophagy is activated in the ischemic heart and is a process that is essential for survival, differentiation, development and homeostasis. 3,3'‑Diindolylmethane (DIM) is a natural product of the acid‑catalyzed condensation of indole‑3‑carbinol in cruciferous vegetables. Numerous studies have suggested that DIM has various pharmacological effects, including antioxidant, antitumor, anti‑angiogenic and anti‑apoptotic properties. However, the function of DIM on hypoxia‑induced cardiac injury remains to be elucidated...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29039495/protective-effects-of-neem-azadirachta-indica-a-juss-leaf-extract-against-cigarette-smoke-and-lipopolysaccharide-induced-pulmonary-inflammation
#14
Jae-Won Lee, Hyung Won Ryu, So-Yeon Park, Hyun Ah Park, Ok-Kyoung Kwon, Heung Joo Yuk, Krishna K Shrestha, Minwoo Park, Jung Hee Kim, Sangwoo Lee, Sei-Ryang Oh, Kyung-Seop Ahn
Neem (Azadirachta indica A. Juss.) leaf has been reported to exert anti-inflammatory, antibacterial and antioxidant effects. The purpose of this study was to investigate the protective effects of neem leaf extract (NLE) against cigarette smoke (CS)- and lipopolysaccharide (LPS)-induced pulmonary inflammation. Treatment with NLE significantly attenuated the infiltration of inflammatory cells, such as neutrophils and macrophages in bronchoalveolar lavage fluid (BALF). NLE also reduced the production of reactive oxygen species and the activity of neutrophil elastase in BALF...
October 10, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29037868/the-fungal-neurotoxin-penitrem-a-induces-the-production-of-reactive-oxygen-species-in-human-neutrophils-at-submicromolar-concentrations
#15
H F Berntsen, I L Bogen, M B Wigestrand, F Fonnum, S I Walaas, A Moldes-Anaya
Penitrem A is a fungal neurotoxin that recurrently causes intoxication in animals, and occasionally also in humans. We have previously reported that penitrem A induced the production of reactive oxygen species (ROS) in rat cerebellar granule cells, opening for a new mechanism of action for the neurotoxin. The aim of this study was to examine the potential of penitrem A to induce ROS production in isolated human neutrophil granulocytes, and to study possible mechanisms involved. Penitrem A significantly increased the production of ROS in human neutrophils at concentrations as low as 0...
October 13, 2017: Toxicology
https://www.readbyqxmd.com/read/29022236/the-protective-effect-of-selenium-on-bovine-mammary-epithelial-cell-injury-caused-by-depression-of-thioredoxin-reductase
#16
Yongmei Guo, Sumei Yan, Jian Gong, Lu Jin, Binlin Shi
To elucidate the effect of selenium (Se) on antioxidant function of mammary glands in dairy cows and the underlying mechanism, an experiment was conducted using a single-factor completely randomized design study. Bovine mammary epithelial cells (BMECs) were randomly divided into four groups: control, Se treatment, 2,4-dinitrochlorobenzene (DNCB) inhibition, and Se prevention. Treatment of BMECs with Se was found to significantly reverse decreased cell proliferation and the expression of thioredoxin reductase (TrxR) after DNCB exposure...
October 11, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29018425/phosphorylation-of-icariin-can-alleviate-the-oxidative-stress-caused-by-the-duck-hepatitis-virus-a-through-mitogen-activated-protein-kinases-signaling-pathways
#17
Wen Xiong, Wei Zhang, Wenjuan Yuan, Hongxu Du, Ke Ming, Fangke Yao, Jingying Bai, Yun Chen, Jiaguo Liu, Deyun Wang, Yuanliang Hu, Yi Wu
The duck virus hepatitis (DVH) caused by the duck hepatitis virus A (DHAV) has produced extensive economic losses to the duck industry. The currently licensed commercial vaccine has shown some defects and does not completely prevent the DVH. Accordingly, a new alternative treatment for this disease is urgently needed. Previous studies have shown that icariin (ICA) and its phosphorylated derivative (pICA) possessed good anti-DHAV effects through direct and indirect antiviral pathways, such as antioxidative stress...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28987363/extract-from-mulberry-morus-australis-leaf-decelerate-acetaminophen-induced-hepatic-inflammation-involving-downregulation-of-myeloid-differentiation-factor-88-myd88-signals
#18
Chi-Ting Horng, Zhi-Hong Liu, Yu-Ting Huang, Huei-Jane Lee, Chau-Jong Wang
Acetaminophen (APAP) induced inflammation and oxidative stress can cause cell death to induce liver damage. The antioxidative and anti-inflammatory effect of Mulberry (Morus australis) leaf extract (MLE) was shown in previous studies. In this study, we investigated the modulation of MLE on APAP induced inflammation and oxidative stress in rat liver injury or liver cancer cell (HepG2). Wistar rat was fed orally with MLE (0.5% or 1.0 %) for 1 week, and then, 900 mg/kg of APAP was injected intraperitoneally (i...
October 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28969111/citral-a-monoterpene-protect-against-high-glucose-induced-oxidative-injury-in-hepg2-cell-in-vitro-an-experimental-study
#19
Sri Devi Subramaniyan, Ashok Kumar Natarajan
INTRODUCTION: Diabetes mellitus, a major metabolic disorder associated with hyperglycaemia is one of the leading cause of death in many developed countries. However, use of natural phytochemicals have been proved to have a protective effect against oxidative damage. AIM: To investigate the effect of citral, a monoterpene on high glucose induced cytotoxicity and oxidative stress in human hepatocellular liver carcinoma (Hep G2) cell line. MATERIALS AND METHODS: Cells were treated with 50 mM concentration of glucose for 24 hours incubation following citral (30 μM) was added to confluent HepG2 cells...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28958941/jip3-deficiency-protects-mice-from-high-fat-diet-induced-liver-injury
#20
Xiao-Juan Rao, Yu-Min Wu, Yan Wang, Shuang-Wei Shi
Multiple pathways contribute to nonalcoholic fatty liver disease (NAFLD) in response to high fat diets (HFD). A homolog of mammalian JNK-interacting protein 3 (JIP3), also known as JSAP-1, activates different components in various signaling pathways to modulate cellular processes. The purpose of this study was to examine the role of JIP3 in obesity-related pathologies pathway. Wild-type (WT) C57BL/6 and JIP3-knockout (JIP3(-/-)) mice were randomized to chow or HFD. HFD-fed WT mice increased hepatic JIP3 expression...
September 25, 2017: Biochemical and Biophysical Research Communications
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