keyword
https://read.qxmd.com/read/38522597/definitive-results-of-a-prospective-non-randomized-phase-2-study-on-stereotactic-body-radiation-therapy-sbrt-for-medically-inoperable-lung-and-liver-oligometastases-from-breast-cancer
#21
JOURNAL ARTICLE
D Franceschini, C Franzese, T Comito, M B Ilieva, R Spoto, A M Marzo, L Dominici, M Massaro, L Bellu, M Badalamenti, P Mancosu, M Scorsetti
BACKGROUND AND PURPOSE: To report mature results for local control and survival in oligometastatic (OM) breast cancer patients treated with stereotactic body radiotherapy (SBRT) on lung and/or liver lesions in a phase II trial. METHODS: This is a prospective non-randomized phase II trial (NCT02581670) which enrolled patients from 2015 to 2021. Eligibility criteria included: age > 18 years, ECOG 0-2, diagnosis of breast cancer, maximum of 4 lung/liver lesions (with a maximum diameter < 5 cm), metastatic disease confined to the lungs and liver or extrapulmonary or extrahepatic disease stable or responding to systemic therapy...
March 22, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38522261/salivary-gland-adenoid-cystic-carcinoma-in-the-u-s-population-importance-of-grade-site-of-metastases-and-adjuvant-radiation-for-survival
#22
JOURNAL ARTICLE
Asad Ullah, Asim Ahmed, Kue Tylor Lee, Abdul Qahar Khan Yasinzai, James S Lewis
BACKGROUND: Adenoid cystic carcinoma (AdCC) is a rare and relatively heterogenous salivary gland malignancy, for which there is debate regarding grading, and clinical prognostic factors, including the role of adjuvant radiotherapy. METHODS: Surveillance, Epidemiology, and End Results (SEER) data were reviewed for AdCC cases from 2000 to 2018. RESULTS: A total of 1978 patients with AdCC were identified. Most patients were between 50 and 59 years of age (21...
March 20, 2024: American Journal of Otolaryngology
https://read.qxmd.com/read/38521617/avelumab-plus-intermittent-axitinib-in-previously-untreated-patients-with-metastatic-renal-cell-carcinoma-the-tide-a-phase-2-study
#23
JOURNAL ARTICLE
Roberto Iacovelli, Chiara Ciccarese, Sebastiano Buti, Paolo Andrea Zucali, Emanuela Fantinel, Davide Bimbatti, Elena Verzoni, Caterina Accettura, Lucia Bonomi, Consuelo Buttigliero, Giuseppe Fornarini, Stefania Pipitone, Francesco Atzori, Cristina Masini, Francesco Massari, Francesca Primi, Alessandro Strusi, Giulia Claire Giudice, Matteo Perrino, Marco Maruzzo, Michele Milella, Diana Giannarelli, Matteo Brunelli, Giuseppe Procopio, Giampaolo Tortora
BACKGROUND: Combinations of vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKIs) plus immune checkpoint inhibitor (ICI) against PD1/PD-L1 are the standard first-line therapy for patients with metastatic renal cell carcinoma (mRCC), irrespective of the prognostic class. OBJECTIVE: To investigate the feasibility and safety of withdrawing VEGFR-TKI but continuing anti-PD1/PD-L1 in patients who achieve a response to their combination...
March 22, 2024: European Urology
https://read.qxmd.com/read/38519913/an-international-phase-ii-trial-and-immune-profiling-of-sbrt-and-atezolizumab-in-advanced-pretreated-colorectal-cancer
#24
JOURNAL ARTICLE
Antonin Levy, Daphné Morel, Matthieu Texier, Roger Sun, Jerome Durand-Labrunie, Maria E Rodriguez-Ruiz, Severine Racadot, Stéphane Supiot, Nicolas Magné, Stacy Cyrille, Guillaume Louvel, Christophe Massard, Loic Verlingue, Fanny Bouquet, Alberto Bustillos, Lisa Bouarroudj, Clément Quevrin, Céline Clémenson, Michele Mondini, Lydia Meziani, Lambros Tselikas, Rastilav Bahleda, Antoine Hollebecque, Eric Deutsch
BACKGROUND: Immuno-radiotherapy may improve outcomes for patients with advanced solid tumors, although optimized combination modalities remain unclear. Here, we report the colorectal (CRC) cohort analysis from the SABR-PDL1 trial that evaluated the PD-L1 inhibitor atezolizumab in combination with stereotactic body radiation therapy (SBRT) in advanced cancer patients. METHODS: Eligible patients received atezolizumab 1200 mg every 3 weeks until progression or unmanageable toxicity, together with ablative SBRT delivered concurrently with the 2nd cycle (recommended dose of 45 Gy in 3 fractions, adapted upon normal tissue tolerance constraint)...
March 23, 2024: Molecular Cancer
https://read.qxmd.com/read/38519408/critical-appraisal-of-surgical-margins-according-to-kras-status-in-liver-resection-for-colorectal-liver-metastases-should-surgical-strategy-be-influenced-by-tumor-biology
#25
JOURNAL ARTICLE
Rami Rhaiem, Adrien Duramé, Florian Primavesi, Dimitri Dorcaratto, Nicholas Syn, Ángela de la Hoz Rodríguez, Aurélien Dupré, Tullio Piardi, Gerardo Blanco Fernández, Arancha Prada Villaverde, Juan C Rodríguez Sanjuán, Roberto Fernández Santiago, María-Carmen Fernández-Moreno, Georgina Ferret, Santiago López Ben, Miguel Á Suárez Muñoz, Alejandro J Perez-Alonso, Ye-Xin Koh, Robert Jones, Elena Martín-Pérez, Reza Kianmanesh, Marcello Di Martino
BACKGROUND: KRAS mutation is a negative prognostic factor for colorectal liver metastases. Several studies have investigated the resection margins according to KRAS status, with conflicting results. The aim of the study was to assess the oncologic outcomes of R0 and R1 resections for colorectal liver metastases according to KRAS status. METHODS: All patients who underwent resection for colorectal liver metastases between 2010 and 2015 with available KRAS status were enrolled in this multicentric international cohort study...
March 21, 2024: Surgery
https://read.qxmd.com/read/38517637/biodistribution-and-dosimetry-of-177-lu-dota-iba-for-therapy-of-bone-metastases
#26
JOURNAL ARTICLE
Hongmei Li, Wenjie Pei, Xiqun Yang, Gengcuo Qu, Qingchu Hua, Lin Liu, Yudi Wang, Tingting Xu, Yue Chen
BACKGROUND: We designed and synthesized a novel bisphosphonate radiopharmaceutical (68  Ga- or 177 Lu-labeled DOTA-ibandronate [68  Ga/177 Lu-DOTA-IBA]) for the targeted diagnosis and treatment of bone metastases. The biodistribution and internal dosimetry of a single therapeutic dose of 177 Lu-DOTA-IBA were evaluated using a series of single-photon emission computerized tomography (SPECT) images and blood samples. Five patients with multiple bone metastases were included in this prospective study...
March 22, 2024: EJNMMI Research
https://read.qxmd.com/read/38516680/diagnosis-and-comprehensive-treatment-of-a-glucagonoma-in-a-patient-with-residual-intrahepatic-metastases-postoperatively-a-case-report-and-literature-review
#27
Shenghui Yu, Muxi Ge, Cheng Zhang, Lang Chen, Lei Zhao
Glucagonomas are rare neuroendocrine neoplasms of the pancreas with malignant potential. At present, their epidemiology is not entirely clear, so clinicians are not well versed, lacking any consensus on diagnosis or comprehensive treatment. The present study reports the case of a 32-year-old woman hospitalized for recurrent glossitis, perioral dermatitis and necrolytic migratory erythema (NME) of both lower limbs. Imaging studies revealed a low-density nodule (~2 cm) in the tail of the pancreas, as well as multiple space-occupying hepatic lesions...
May 2024: Oncology Letters
https://read.qxmd.com/read/38516491/gastric-neuroendocrine-tumor-with-cystic-hepatic-metastases-mimicking-hepatic-echinococcosis-a-case-report
#28
Rahul Gupta, Deepak Gusain, Nalini Bansal, Rahul Varshney, Arvind Singh
Metastatic gastrointestinal neuroendocrine tumors classically appear as contrast-enhancing lesions on computed tomography. However, in a small percentage of patients, these lesions can be cystic in nature, leading to false diagnoses of benign or infectious lesions such as echinococcosis. Hence, every cystic lesion of the liver must be carefully investigated before making the treatment plan. We report a patient with hematemesis caused by a large gastric ulcer with multiple cystic lesions in the left lobe of the liver abutting the stomach...
February 2024: Curēus
https://read.qxmd.com/read/38516428/benign-or-by-chance-a-case-report-on-incidental-appendectomy-revealing-a-neuroendocrine-tumor-during-traumatic-exploratory-laparotomy
#29
Megan B Douglass, Sheldon L Carpenter, Cayla H Campbell, Chase Hoffman, Jacob Hessey
Incidental appendectomies (IAs) are often performed in laparotomies to prevent future complications caused by the buildup of scar tissue. Although neoplastic findings are rare, all appendectomy specimens should be sent for histopathological analysis. We present the case of a 38-year-old man found to have an appendiceal neuroendocrine tumor (NET) after receiving an IA secondary to a traumatic rectal perforation requiring exploratory laparotomy. Well-differentiated NETs isolated to the appendix have an excellent prognosis...
February 2024: Curēus
https://read.qxmd.com/read/38516028/an-in-silico-planning-study-of-stereotactic-body-radiation-therapy-for-polymetastatic-patients-with-more-than-ten-extra-cranial-lesions
#30
JOURNAL ARTICLE
Federico Iori, Nathan Torelli, Jan Unkelbach, Stephanie Tanadini-Lang, Sebastian M Christ, Matthias Guckenberger
BACKGROUND AND PURPOSE: Limited data is available about the feasibility of stereotactic body radiation therapy (SBRT) for treating more than five extra-cranial metastases, and almost no data for treating more than ten. The aim of this study was to investigate the feasibility of SBRT in this polymetatstatic setting. MATERIALS AND METHODS: Consecutive metastatic melanoma patients with more than ten extra-cranial metastases and a maximum lesion diameter below 11 cm were selected from a single-center prospective registry for this in-silico planning study...
April 2024: Physics and Imaging in Radiation Oncology
https://read.qxmd.com/read/38515950/complementary-comments-on-metastatic-liver-lesions-with-exceptional-and-rare-cases
#31
JOURNAL ARTICLE
Kemal Bugra Memis, Sonay Aydin
Liver metastases can appear in different forms in magnetic resonance imaging. Contrary to popular belief, while radiologists report hypovascular or hypervascular metastatic lesions, exceptional examples may be detected in various tumors. The aim of this article is to improve this review by presenting rare and atypical examples of liver metastasis, as well as cases that might potentially be misdiagnosed as metastases during the process of differential diagnosis.
February 21, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38515943/current-landscape-of-preoperative-neoadjuvant-therapies-for-initial-resectable-colorectal-cancer-liver-metastasis
#32
REVIEW
Xiao-Fei Cheng, Feng Zhao, Dong Chen, Fan-Long Liu
Colorectal cancer liver metastasis (CRLM) presents a clinical challenge, and optimizing treatment strategies is crucial for improving patient outcomes. Surgical resection, a key element in achieving prolonged survival, is often linked to a heightened risk of recurrence. Acknowledging the potential benefits of preoperative neoadjuvant chemotherapy in managing resectable liver metastases, this approach has gained attention for its role in tumor downsizing, assessing biological behavior, and reducing the risk of postoperative recurrence...
February 21, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38514344/-effectiveness-of-minimally-invasive-surgery-in-the-treatment-of-pancreatic-acinar-cell-carcinoma
#33
JOURNAL ARTICLE
M Tao, C H Yuan, C L Ma, B Jiang, L Li, H Y Wang, D R Xiu
Objective: To explore the effectiveness of minimally invasive surgical treatment for pancreatic acinar cell carcinoma (PACC). Methods: Six patients with PACC diagnosed in Peking University Third Hospital from January 2010 to September 2022 were retrospectively selected. Preoperative evaluation was performed on whether the lesions were eligible for surgery, including whether radical resection of liver metastases could be performed. Laparoscopic or Da Vinci robot-assisted resection was performed on six patients, and spleen retention was determined according to the original lesions and the relationship with peripheral blood vessels and tissues, while simultaneous resection was performed on cases of peripheral organ tissue invasion...
March 26, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38513142/chemotherapy-induced-pneumatosis-intestinalis-followed-by-hepatic-portal-venous-gas-a-case-report
#34
JOURNAL ARTICLE
WenJun Pan, Shuai Xiang, Junhao Zhang, Yuan Gao, Shanglong Liu
Pneumatosis intestinalis (PI) is a rare disease, and there are many theories about its pathogenesis. Hepatic portal venous gas (HPVG), is thought to occur secondary to intramural intestinal gas emboli migrating through the portal venous system via the mesenteric veins. PI accompanied by HPVG is usually a sign of bowel ischaemia and is associated with a high mortality rate. We report here, a patient with liver metastases from colorectal cancer who developed PI followed by HPVG after treatment with 5-Fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6)...
March 2024: Journal of International Medical Research
https://read.qxmd.com/read/38512350/ultrasound-guided-robotic-surgical-procedures-a-systematic-review
#35
REVIEW
Matteo Pavone, Barbara Seeliger, Elena Teodorico, Marta Goglia, Cristina Taliento, Nicolò Bizzarri, Lise Lecointre, Cherif Akladios, Antonello Forgione, Giovanni Scambia, Jacques Marescaux, Antonia C Testa, Denis Querleu
INTRODUCTION: Ultrasound has been nicknamed "the surgeon's stethoscope". The advantages of laparoscopic ultrasound beyond a substitute for the sense of touch are considerable, especially for robotic surgery. Being able to see through parenchyma and into vascular structures enables to avoid unnecessary dissection by providing a thorough assessment at every stage without the need for contrast media or ionising radiation. The limitations of restricted angulation and access within the abdominal cavity during laparoscopy can be overcome by robotic handling of miniaturised ultrasound probes and the use of various and specific frequencies will meet tissue- and organ-specific characteristics...
March 21, 2024: Surgical Endoscopy
https://read.qxmd.com/read/38512117/a-signal-finding-study-of-abemaciclib-in-heavily-pretreated-patients-with-metastatic-castration-resistant-prostate-cancer-results-from-cyclone-1
#36
JOURNAL ARTICLE
Neeraj Agarwal, Daniel Castellano, Teresa Alonso-Gordoa, Jose Angel Arranz Arija, Emeline Colomba, Gwenaelle Gravis, Loic Mourey, Stephane Oudard, Aude Fléchon, Macarena Gonzalez, Pablo M Maroto, Michael T Schweizer, Enrique Gallardo, Erica Johnston, Arjun Balar, Nadine Haddad, Adams K Appiah, Karim Nacerddine, Josep M Piulats
BACKGROUND: Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors radically changed the treatment paradigm for breast cancer. Similar to estrogen receptor in breast cancer, androgen receptor signaling activates cyclin D-CDK4/6, driving proliferation and resistance to hormonal manipulation in prostate cancer. This study was designed to detect signals of clinical activity for abemaciclib in treatment-refractory metastatic castration-resistant prostate cancer (mCRPC). METHODS: Eligible patients had progressive mCRPC, measurable disease, and previously received ≥1 novel hormonal agent(s) and 2 lines of taxane chemotherapy...
March 21, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38511680/effective-and-safe-treatment-of-risky-localized-liver-tumors-using-microwave-ablation-in-patients-with-comorbid-lung-diseases-unfit-for-deep-anesthesia
#37
JOURNAL ARTICLE
Murat Asik
OBJECTIVE: To assess the safety and efficacy of percutaneous microwave ablation (MWA) in treating high-risk localized liver tumors in patients unable to undergo deep anesthesia because of comorbid lung diseases. METHODS: Between January 2019 and January 2022, percutaneous MWA procedures were performed for 50 liver tumors. These lesions were situated in close proximity to anatomically essential structures, with a maximum distance to surrounding structures being 10 mm...
March 21, 2024: Medeniyet medical journal
https://read.qxmd.com/read/38509970/exosomes-promote-pre-metastatic-niche-formation-in-colorectal-cancer
#38
REVIEW
Guifei Si, Xuemei Chen, Yuquan Li, Xuemin Yuan
It is well known that colorectal cancer (CRC) has a high morbidity rate, a poor prognosis when metastasized, and a greatly shortened 5-year survival rate. Therefore, understanding the mechanism of tumor metastasis is still important. Based on the "seed and soil" theory, the concept of " premetastatic niche (PMN)" was introduced by Kaplan et al. The complex interaction between primary tumors and the metastatic organ provides a beneficial microenvironment for tumor cells to colonize at a distance. With further exploration of the PMN, exosomes have gradually attracted interest from researchers...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38508239/cancer-specific-dose-and-fractionation-schedules-in-stereotactic-body-radiotherapy-for-oligometastatic-disease-an-interim-analysis-of-the-eortc-estro-e-2-radiate-oligocare-study
#39
JOURNAL ARTICLE
Sebastian M Christ, Filippo Alongi, Umberto Ricardi, Marta Scorsetti, Lorenzo Livi, Panagiotis Balermpas, Yolande Lievens, Pètra Braam, Barbara Alicja Jereczek-Fossa, Karin Stellamans, Ivica Ratosa, Joachim Widder, Heike Peulen, Piet Dirix, Samuel Bral, Sara Ramella, Hossein Hemmatazad, Kaouthar Khanfir, Xavier Geets, Paul Jeene, Thomas Zilli, Beatrice Fournier, Giovanni Battista Ivaldi, Enrico Clementel, Catherine Fortpied, Felix Boakye Oppong, Piet Ost, Matthias Guckenberger
BACKGROUND AND INTRODUCTION: Optimal dose and fractionation in stereotactic body radiotherapy (SBRT) for oligometastatic cancer patients remain unknown. In this interim analysis of OligoCare, we analyzed factors associated with SBRT dose and fractionation. MATERIALS AND METHODS: Analysis was based on the first 1,099 registered patients. SBRT doses were converted to biological effective doses (BED) using α/β of 10 Gy for all primaries, and cancer-specific α/β of 10 Gy for non-small cell lung and colorectal cancer (NSCLC, CRC), 2...
March 18, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38507173/laparoscopic-liver-resection-as-a-treatment-option-for-intrahepatic-cholangiocarcinoma
#40
JOURNAL ARTICLE
Kyeong Deok Kim, Ji Eun Lee, Jongman Kim, Junsoo Ro, Jinsoo Rhu, Gyu-Seong Choi, Jin Seok Heo, Jae-Won Joh
Laparoscopic liver resection (LLR) remains controversial in the treatment of intrahepatic cholangiocarcinoma (ICC). The aim of the present study is to investigate the outcomes of LLR for ICC compared to open liver resection (OLR). We retrospectively reviewed patients who underwent surgery for ICC between January 2013 and February 2020. OLR and LLR were compared after propensity score matching (PSM). Overall survival (OS) and recurrence-free survival (RFS) were compared between the matched groups. During the study period, 219 patients met the inclusion criteria (OLR = 170 patients, 77...
March 20, 2024: Updates in Surgery
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