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https://www.readbyqxmd.com/read/28550028/the-impact-of-a-hepatobiliary-multidisciplinary-team-assessment-in-patients-with-colorectal-cancer-liver-metastases-a-population-based-study
#1
Jennie Engstrand, Nikolaos Kartalis, Cecilia Strömberg, Mats Broberg, Anna Stillström, Tobias Lekberg, Eduard Jonas, Jacob Freedman, Henrik Nilsson
BACKGROUND: Assessing patients with colorectal cancer liver metastases (CRCLM) by a liver multidisciplinary team (MDT) results in higher resection rates and improved survival. The aim of this study was to evaluate the potentially improved resection rate in a defined cohort if all patients with CRCLM were evaluated by a liver MDT. PATIENTS AND METHODS: A retrospective analysis of patients diagnosed with colorectal cancer during 2008 in the greater Stockholm region was conducted...
May 26, 2017: Oncologist
https://www.readbyqxmd.com/read/28549012/ras-mutation-clinical-risk-score-to-predict-survival-after-resection-of-colorectal-liver-metastases
#2
Kristoffer W Brudvik, Robert P Jones, Felice Giuliante, Junichi Shindoh, Guillaume Passot, Michael H Chung, Juhee Song, Liang Li, Vegar J Dagenborg, Åsmund A Fretland, Bård Røsok, Agostino M De Rose, Francesco Ardito, Bjørn Edwin, Elena Panettieri, Luigi M Larocca, Suguru Yamashita, Claudius Conrad, Thomas A Aloia, Graeme J Poston, Bjørn A Bjørnbeth, Jean-Nicolas Vauthey
OBJECTIVE: To determine the impact of RAS mutation status on the traditional clinical score (t-CS) to predict survival after resection of colorectal liver metastases (CLM). BACKGROUND: The t-CS relies on the following factors: primary tumor nodal status, disease-free interval, number and size of CLM, and carcinoembryonic antigen level. We hypothesized that the addition of RAS mutation status could create a modified clinical score (m-CS) that would outperform the t-CS...
May 25, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28546418/single-cell-dna-sequencing-reveals-a-late-dissemination-model-in-metastatic-colorectal-cancer
#3
Marco L Leung, Alexander Davis, Ruli Gao, Anna Casasent, Yong Wang, Emi Sei, Eduardo Sanchez, Dipen Maru, Scott Kopetz, Nicholas E Navin
Metastasis is a complex biological process that has been difficult to delineate in human colorectal (CRC) cancer patients. A major obstacle in understanding metastatic lineages is the extensive intratumor heterogeneity at the primary and metastatic tumor sites. To address this problem, we developed a highly-multiplexed single cell DNA sequencing approach to trace the metastatic lineages of two CRC patients with matched liver metastases. Single cell copy number or mutational profiling was performed, in addition to bulk exome and targeted deep-sequencing...
May 25, 2017: Genome Research
https://www.readbyqxmd.com/read/28545511/gastric-hepatoid-adenocarcinoma-resulting-in-a-spontaneous-gastric-perforation-a-case-report-and-review-of-the-literature
#4
Junichi Yoshizawa, Satoshi Ishizone, Meguru Ikeyama, Jun Nakayama
BACKGROUND: Gastric hepatoid adenocarcinoma (GHAC) is an atypical form of gastric cancer (GC) that has similar tissue morphology to hepatocellular carcinoma and frequently produces alpha-fetoprotein. We present an exceedingly rare case of GHAC resulting in a spontaneous gastric perforation. CASE PRESENTATION: A 61-year-old man presented at our institution complaining of abdominal and back pain. A computed tomography scan revealed a spontaneous gastric perforation with a solitary liver tumor and lymph node swelling...
May 25, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28543544/the-prognostic-utility-of-the-tumor-burden-score-based-on-preoperative-radiographic-features-of-colorectal-liver-metastases
#5
Kazunari Sasaki, Georgios A Margonis, Nikolaos Andreatos, Xu-Feng Zhang, Stefan Buettner, Jaeyun Wang, Amar Deshwar, Jin He, Christopher L Wolfgang, Matthew Weiss, Timothy M Pawlik
BACKGROUND: Recently, a tumor-burden "metro ticket" score (TBS) based on final pathology was proposed to predict outcome following resection of colorectal liver metastasis (CRLM). We sought to validate the TBS prognostic tool using preoperative radiologic cross-sectional imaging. METHODS: Imaging TBS was defined on a Cartesian plane that incorporated both maximum tumor size (x-axis) and lesion number (y-axis) assessed by pre-operative imaging. The discriminatory power (area under the curve [AUC]) and goodness-of-fit (Harrel's C statistic and Somer's D statistics) of the imaging TBS model was assessed...
May 25, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28543176/regional-immunotherapy-for-liver-and-peritoneal-metastases
#6
REVIEW
Jeffrey Reha, Steven C Katz
Pancreatic adenocarcinoma is a biologically aggressive disease, with liver and peritoneal metastases being a frequent cause of death. We examine how the pancreatic carcinoma microenvironment and immunosuppressive landscape favor tumor progression. Immunotherapy has shown promise in select solid tumors, yet challenges remain in applying these gains to stage IV pancreatic adenocarcinoma. We discuss how regional therapy strategies may be leveraged to open new avenues for treating pancreatic carcinoma metastases with immunotherapy...
May 22, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28542731/systematic-review-of-the-influence-of-chemotherapy-associated-liver-injury-on-outcome-after-partial-hepatectomy-for-colorectal-liver-metastases
#7
REVIEW
J Zhao, K M C van Mierlo, J Gómez-Ramírez, H Kim, C H C Pilgrim, P Pessaux, S S Rensen, E P van der Stok, F G Schaap, O Soubrane, T Takamoto, L Viganò, B Winkens, C H C Dejong, S W M Olde Damink
BACKGROUND: The impact of chemotherapy-associated liver injury (CALI) on postoperative outcome in patients undergoing partial hepatectomy for colorectal liver metastases (CRLM) remains controversial. The objective of this study was to clarify the effect of CALI (sinusoidal dilatation (SD), steatosis and steatohepatitis) on postoperative morbidity and mortality by investigating a large data set from multiple international centres. METHODS: PubMed and Embase were searched for studies published between 1 January 2004 and 31 December 2013 with keywords 'chemotherapy', 'liver resection', 'outcome' and 'colorectal metastases' to identify potential collaborating centres...
May 25, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28542671/folfoxiri-plus-bevacizumab-as-conversion-therapy-for-patients-with-initially-unresectable-metastatic-colorectal-cancer-a-systematic-review-and-pooled-analysis
#8
Gianluca Tomasello, Fausto Petrelli, Michele Ghidini, Alessandro Russo, Rodolfo Passalacqua, Sandro Barni
Importance: The combination of fluorouracil, oxaliplatin, and irinotecan plus bevacizumab (FOLFOXIRI-Bev) is an established and effective first-line chemotherapy regimen for metastatic colorectal cancer. However, resection rates of metastases and overall survival with this schedule have never been systematically evaluated in published studies including, but not limited to, the TRIBE (TRIplet plus BEvacizumab) trial. Objective: To assess the clinical efficacy of FOLFOXIRI-Bev, including outcomes and rates of surgical conversions...
May 25, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28540787/microwave-ablation-is-effective-against-liver-metastases-from-gastric-adenocarcinoma
#9
Fubo Zhou, Xiao-Ling Yu, Ping Liang, Zhigang Cheng, Zhi-Yu Han, Jie Yu, Fangyi Liu, Yi Hu
PURPOSE: The resection rate for liver metastases from gastric cancer is only 1.4-21.1%. This study aimed to evaluate the safety and therapeutic efficacy of microwave ablation (MWA) for liver metastases from gastric adenocarcinoma (LMGC). MATERIALS AND METHODS: A database of 108 gastric adenocarcinoma patients with liver metastases who underwent MWA (n = 32) or systemic chemotherapy (n = 76) for LMGC between 2008 and 2016 was reviewed. Overall survival curves were assessed and compared based on different therapies...
March 29, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28540062/frequency-and-locations-of-systemic-metastases-in-merkel-cell-carcinoma-by-imaging
#10
Maria Kouzmina, Virve Koljonen, Junnu Leikola, Tom Böhling, Eila Lantto
BACKGROUND: The primary neuroendocrine skin cancer, Merkel cell carcinoma (MCC), has a well-known predilection to metastasize systemically. However, the experience of systemic metastases in MCC is mainly disseminated through case reports due to the rarity of MCC. PURPOSE: To elucidate the frequency and locations of systemic metastasis in MCC by reviewing the imaging of patients with metastatic MCC in a national cohort. MATERIAL AND METHODS: Patients with diagnosed metastatic MCC by imaging studies in Finland during 1999-2012 were included in this study...
March 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/28538405/marked-response-to-nab-paclitaxel-in-egfr-mutated-lung-neuroendocrine-carcinoma-a-case-report
#11
Jin-Yan Liang, Fan Tong, Fei-Fei Gu, Yang-Yang Liu, Yu-Lan Zeng, Xiao-Hua Hong, Kai Zhang, Li Liu
RATIONALE: Lung cancer is the leading cause of cancer-related death in the world. Tyrosine kinase inhibitors (TKIs), which target mutated epidermal growth factor receptor (EGFR), have been the first-line treatment of late-stage lung adenocarcinoma harboring EGFR mutation. EGFR mutations are mostly identified in lung adenocarcinoma. However, it is rarely seen in lung neuroendocrine carcinoma, and treatment strategies remain under reported. PATIENT CONCERNS: Here, we describe a 54-year-old Chinese man diagnosed with lung adenocarcinoma (cT4N3M1b, stage IV) with neuroendocrine differentiation and L858R mutation on exon 21...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28536968/clinical-and-imaging-based-prognostic-factors-in-radioembolisation-of-liver-metastases-from-colorectal-cancer-a-retrospective-exploratory-analysis
#12
Kathy P Willowson, Aimee R Hayes, David L H Chan, Michael Tapner, Elizabeth J Bernard, Richard Maher, Nick Pavlakis, Stephen J Clarke, Dale L Bailey
BACKGROUND: The aim of this study was to investigate the relationship between absorbed dose and response of colorectal cancer liver metastases treated with [(90)Y]-resin microspheres and to explore possible clinical and imaging derived prognostic factors. METHODS: FDG PET/CT was used to measure response of individual lesions to a measured absorbed dose, derived from post-treatment (90)Y PET imaging. Predicted dose was also derived from planning [(99m)Tc]-MAA SPECT data...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28536806/increased-infiltration-of-natural-killer-and-t-cells-in-colorectal-liver-metastases-improves-patient-overall-survival
#13
Matteo Donadon, Kelly Hudspeth, Matteo Cimino, Luca Di Tommaso, Max Preti, Paolo Tentorio, Massimo Roncalli, Domenico Mavilio, Guido Torzilli
INTRODUCTION: Cancer heterogeneity and degree of intra-tumoral immune cells represent variables affecting overall survival (OS). The present study investigated the impact of natural killer (NK) and T cells infiltrating colorectal liver metastases (CLM) in patients undergoing hepatectomy after neoadjuvant chemotherapy. METHODS: The frequencies of intra-tumoral, marginal, and peritumoral CD3+ T and NKp46+ NK cells were determined for 121 patients. OS was assessed in relation to prognostic factors...
May 23, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28536686/mandible-metastasis-of-small-cell-lung-cancer-mimicking-a-residual-cyst
#14
Renata Mendonça Moraes, Fabio Abreu Alves, Bruna Fernandes do Carmo Carvalho, Felipe D'Almeida Costa, Rodrigo Nascimento Lopes, Graziella Chagas Jaguar
Small cell lung carcinoma (SCLC) is an uncommon tumor characterized by an aggressive behavior with early metastasis, usually to the contralateral lung, liver, brain, and bones. There are only five cases of this particular tumor metastasizing to the oral cavity described in the English literature. We present the case of metastatic SCLC in the mandible with radiographic findings resembling a residual cyst. A 66-year-old man with previous diagnosis and treatment for a SCLC was referred to the Stomatology Department with a history of persistent pain in the mandible 1 year after the inferior right pre-molar tooth extraction...
January 2017: Autopsy & case reports
https://www.readbyqxmd.com/read/28536445/inhibition-of-pi3k-suppresses-propagation-of-drug-tolerant-cancer-cell-subpopulations-enriched-by-5-fluorouracil
#15
Kaoru Ishida, Chie Ito, Yukimi Ohmori, Kohei Kume, Kei A Sato, Yuka Koizumi, Akari Konta, Takeshi Iwaya, Mamoru Nukatsuka, Takashi Kobunai, Teiji Takechi, Satoshi S Nishizuka
Drug-tolerant cancer cell subpopulations are responsible for relapse after chemotherapy. By continuously exposing the gastric cancer cell line MKN45 to 5-FU for >100 passages, we established a 5-fluorouracil (5-FU)-tolerant line, MKN45/5FU. Orthotopic xenografts of MKN45/5FU cells in the stomach of nude mice revealed that these cells had a high potential to metastasize to sites such as the liver. Levels of phosphorylated phosphatidylinositide 3-kinase (PI3K) increased both in 5-FU-tolerant subpopulations according to the 5-FU dose, and in gastric submucosal orthotopic xenografts of MKN45/5FU cells...
May 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28536342/-a-case-of-late-recurrence-of-breast-cancer-causing-multiple-organ-metastases-27-years-postoperatively
#16
Kimiyasu Yoneyama, Hiroshi Nakamura, Naotaka Tobe
The patient was a 77-year-old female with a history of treatment for cancer of the right breast 27 years earlier, who presented with a chief complaint of a subcutaneous mass in the left lower quadrant of her abdomen. A thorough examination revealed high breast cancer-related tumor marker values, and based on a computed tomography(CT)examination, a tentative diagnosis of multiple lung, liver, retroperitoneal, and abdominal wall metastases was made. Although there were multiple organ metastases, in view of the long interval before the recurrence, absence of any symptoms, and the patient's age, we initiated treatment by weekly administration of an aromatase inhibitor and trastuzumab...
May 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28536339/-a-case-report-on-a-successful-resection-after-folfiri-plus-cetuximab-therapy-for-unresectable-colorectal-cancer-with-multiple-liver-metastases
#17
Min Kanamori, Yasuhiro Kurumiya, Keisuke Mizuno, Ei Sekoguchi, Satoshi Kobayashi, Yasuyuki Fukami, Muneyasu Kiriyama, Hiroki Aoyama, Takashi Oiwa, Kei Miyamura, Takanori Jinno, Yu Nakashima, Makiko Mori
The patient was a 66-year-old woman with a history of right breast cancer 20 years prior. Her chief complaint was hematochezia, and she was diagnosed as having rectal cancer. She underwent laparoscopic high anterior resection. We made a diagnosis of moderately differentiated adenocarcinoma, type 2, 25×20 mm, pMP, pN0, Stage I, KRAS being wild-type. Multiple liver metastases were detected 6 months after the surgery. Tumor contacted with grison. The tumor was not completely resected as evidenced by the small liver remnant volume...
May 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28536280/liver-metastasis-is-facilitated-by-the-adherence-of-circulating-tumor-cells-to-vascular-fibronectin-deposits
#18
Jorge Barbazan, Lorena Alonso-Alconada, Nadia Elkhatib, Sara Geraldo, Vasily Gurchenkov, Alexandros Glentis, Guillaume van Niel, Roberta Palmulli, Beatriz Fernandez, Patricia Viaño, Tomás García-Caballero, Rafael López López, Miguel Abal, Danijela Matic Vignjevic
The interaction between circulating tumor cells (CTC) and endothelial cells during extravasation is a critical process during metastatic colonization, but its mechanisms remain poorly characterized. Here we report that the luminal side of liver blood vessels contains fibronectin deposits that are enriched in mice bearing primary tumors and are also present in vessels from human livers affected with metastases. Cancer cells attached to endothelial fibronectin deposits via talin1, a major component of focal adhesions...
May 23, 2017: Cancer Research
https://www.readbyqxmd.com/read/28534367/laparoscopic-hepatectomy-for-colorectal-liver-metastases-located-in-all-segments-of-the-liver
#19
Deqing Wu, Wulin Wu, Yong Li, Shuntian Liang, Junjiang Wang, Xueqing Yao, Zhixiang Jian
PURPOSE: Laparoscopic hepatectomy is not a well-established treatment modality for colorectal liver metastases. Moreover, most reports have been limited to tumors in the anterolateral segments (segments 2, 3, 4b, 5, and 6). We evaluated the short- and long-term outcomes after laparoscopic hepatectomy for colorectal liver metastases located in all segments, including tumors located in the posterosuperior segments (segments 1, 4a, 7, and 8). METHODS: TThis retrospective study included 102 patients who underwent laparoscopic hepatectomy for colorectal liver metastases with radical intent between January 2009 and January 2016...
March 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28533641/image-findings-of-a-rare-case-of-neuroendocrine-tumor-metastatic-to-orbital-extraocular-muscle-in-gallium-68-dotanoc-positron-emission-tomography-computed-tomography-and-therapy-with-lutetium-177-dotatate
#20
Koramadai Karuppusamy Kamaleshwaran, Jephy Joseph, Indra Upadhya, Ajit Sugunan Shinto
Metastatic tumor is one of several etiologies of space-occupying masses in the orbit that accounts for 1-13% of all orbital masses. In the adult patient population, breast cancer is the most common tumor to metastasize to the orbit, followed by metastasis from the lung, prostate, and gastrointestinal tract. Carcinoid tumors are rare neuroendocrine neoplasms derived from enterochromaffin cells, which are found primarily in the gastrointestinal tract and bronchial tree. Liver metastases are the classic presentation of distant disease...
April 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
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