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Liver metastases

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https://www.readbyqxmd.com/read/28938688/drag-reducing-polymers-decrease-hepatic-injury-and-metastases-after-liver-ischemia-reperfusion
#1
Samer Tohme, Marina V Kameneva, Hamza O Yazdani, Vikas Sud, Julie Goswami, Patricia Loughran, Hai Huang, Richard L Simmons, Allan Tsung
INTRODUCTION: Surgery, a crucial therapeutic modality in the treatment of solid tumors, can induce sterile inflammatory processes which can result in metastatic progression. Liver ischemia and reperfusion (I/R) injury, an inevitable consequence of hepatic resection of metastases, has been shown to foster hepatic capture of circulating cancer cells and accelerate metastatic growth. Efforts to reduce these negative consequences have not been thoroughly investigated. Drag reducing polymers (DRPs) are blood-soluble macromolecules that can, in nanomolar concentrations, increase tissue perfusion, decrease vascular resistance and decrease near-wall microvascular concentration of neutrophils and platelets thereby possibly reducing the inflammatory microenvironment...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938458/corticotroph-pituitary-carcinoma-in-a-patient-with-lynch-syndrome-ls-and-pituitary-tumors-in-a-nationwide-ls-cohort
#2
Daniel Bengtsson, Patrick Joost, Christos Aravidis, Marie Askmalm Stenmark, Ann-Sofie Backman, Beatrice Melin, Jenny von Salomé, Theofanis Zagoras, Samuel Gebre-Medhin, Pia Burman
Context: Lynch syndrome is a cancer predisposing syndrome caused by germline mutations in genes involved in DNA mismatch repair (MMR). Patients are at high risk for several types of cancer, but pituitary tumors have not previously been reported. Case: A 51-year old man with LS (MSH2 mutation) and a history of colon carcinoma presented with severe Cushing's disease and a locally aggressive pituitary tumor. The tumor harbored a mutation consistent with the patient's germline mutation, and displayed defect MMR function...
August 18, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28937543/cholangiocarcinoma-among-children-and-adolescents-a-review-of-the-literature-and-seer-database-analysis
#3
Jennifer R Newsome, Rajkumar Venkatramani, Andras Heczey, Heather E Danysh, Douglas S Fishman, Tamir Miloh
OBJECTIVES: Cholangiocarcinoma (CCA) is a biliary malignancy found primarily in adults. The incidence of CCA in children is unknown. The aim of this study was to describe characteristics of CCA in children and adolescents. METHODS: Using the Surveillance, Epidemiology, and End Results Program (SEER 18) database, we identified incident cases of CCA diagnosed at <20 years of age during the period of 1973-2013. Additionally, we reviewed published case reports describing pediatric patients with CCA...
September 20, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28936708/impact-of-visceral-adiposity-as-well-as-sarcopenic-factors-on-outcomes-in-patients-undergoing-liver-resection-for-colorectal-liver-metastases
#4
Atsushi Kobayashi, Toshimi Kaido, Yuhei Hamaguchi, Shinya Okumura, Hisaya Shirai, Naoko Kamo, Shintaro Yagi, Kojiro Taura, Hideaki Okajima, Shinji Uemoto
OBJECTIVES: We have reported preoperative low skeletal muscularity as an independent risk factor for poor outcomes after liver transplantation, resection of hepatocellular carcinoma, pancreatic cancer and extrahepatic biliary malignancies. However, the impacts of visceral adiposity and muscularity on outcomes after liver resection for colorectal liver metastases (CLM) have not been fully investigated. METHODS: We retrospectively analyzed 124 patients undergoing primary liver resection for CLM between 2005 and 2014...
September 21, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28935452/3d-image-guidance-assisted-identification-of-colorectal-cancer-liver-metastases-not-seen-on-intraoperative-ultrasound-results-from-a-prospective-trial
#5
T Peter Kingham, Linda M Pak, Amber L Simpson, Universe Leung, Alexandre Doussot, Michael I D'Angelica, Ronald P DeMatteo, Peter J Allen, William R Jarnagin
BACKGROUND: Neoadjuvant treatment of colorectal liver metastases has become increasingly common, and while effective, often renders small metastases difficult to visualize on intraoperative US. The objective of this study was to determine the utility of a 3D image-guidance system in patients with intraoperative sonographically-occult CRLM. METHODS: 50 patients with at least one CRLM ≤ 1.5 cm were enrolled in this prospective trial of an FDA-approved Explorer image-guidance system...
September 18, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28931429/portal-vein-embolization-with-n-butyl-cyanoacrylate-through-an-ipsilateral-approach-before-major-hepatectomy-single-center-analysis-of-50-consecutive-patients
#6
José Hugo Mendes Luz, Paula Mendes Luz, Tiago Bilhim, Henrique Salas Martin, Hugo Rodrigues Gouveia, Élia Coimbra, Filipe Veloso Gomes, Roberto Romulo Souza, Igor Murad Faria, Tiago Nepomuceno de Miranda
PURPOSE: To evaluate the efficacy of portal vein embolization (PVE) with n-Butyl-cyanoacrylate (NBCA) through an ipsilateral approach before major hepatectomy. Secondary end-points were PVE safety, liver resection and patient outcome. METHODS: Over a 5-year period 50 non-cirrhotic consecutive patients were included with primary or secondary liver cancer treatable by hepatectomy with a liver remnant (FLR) volume less than 25% or less than 40% in diseased livers. RESULTS: There were 37 men and 13 women with a mean age of 57 years...
September 20, 2017: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/28931294/-carney-triad
#7
L Fiala, I Kocáková, R Šimůnek, E Krejčí, I Babánková, R Šefr
Carney triad is a synchronous or metachronous association of gastric gastrointestinal stromal tumors (GIST), pulmonary chondroma and extra-adrenal paraganglioma. The majority of patients have only one or two components of the triad, all three tumors being found in only about 2% of the patients at the time of the first diagnosis. The most common combination is gastric and pulmonary tumors. We report a case of Carney triad which was diagnosed at Masaryk Memorial Cancer Institute. A 57-year-old female patient with a history of gastric resection for leiomyosarcoma at the age of 14 and with an unclear pulmonary lesion evident on chest X-ray since as early as 2003...
2017: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/28930294/surgery-kras-mutations-and-hepatic-recurrence-after-treatment-of-colorectal-liver-metastases
#8
Kristoffer Watten Brudvik, Jean-Nicolas Vauthey
No abstract text is available yet for this article.
September 20, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28929463/individualized-treatment-sequencing-selection-contributes-to-optimized-survival-in-patients-with-rectal-cancer-and-synchronous-liver-metastases
#9
Claudius Conrad, Jean-Nicolas Vauthey, Okuno Masayuki, Rahul A Sheth, Suguru Yamashita, Guillaume Passot, Christina E Bailey, Daria Zorzi, Scott Kopetz, Thomas A Aloia, Y Nancy You
BACKGROUND: The optimal treatment sequence for patients with advanced rectal cancer and synchronous resectable liver metastases is controversial. We examined the outcomes associated with an individualized selection of classic, reversed, or combined approaches. METHODS: Between 1999 and 2014, 268 patients with rectal cancer and synchronous liver-only metastases underwent curative-intent multimodality therapy. Demographics and tumor and treatment details were reviewed...
September 19, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28929341/margin-status-is-still-an-important-prognostic-factor-in-hepatectomies-for-colorectal-liver-metastases-a-propensity-score-matching-analysis
#10
Riccardo Memeo, Vito de Blasi, Rene Adam, Diane Goéré, Tullio Piardi, Emilie Lermite, Olivier Turrini, Francis Navarro, Nicola de'Angelis, Antonio Sa Cunha, Patrick Pessaux
OBJECTIVE: The width of resection margin is still a matter of debate in case of colorectal liver metastasis resection. The aim of this study was to determine the risk factors for R1 resection. Once risk factors had been identified, patients were matched according to Fong's prognostic criteria, in order to evaluate whether R1 resection still remained a negative prognostic factor impacting overall and disease-free survival. METHODS: A total of 1784 hepatectomies were analyzed from a multicentric retrospective cohort of hepatectomies...
September 19, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28928842/significant-response-to-ramucirumab-monotherapy-in-chemotherapy-resistant-recurrent-alpha-fetoprotein-producing-gastric-cancer-a-case-report
#11
Yasuhiro Arakawa, Miho Tamura, Keisuke Aiba, Kazuhiko Morikawa, Daisuke Aizawa, Masahiro Ikegami, Masami Yuda, Katsunori Nishikawa
Alpha-fetoprotein (AFP)-producing gastric cancer (AFPGC) is a relatively rare type of gastric cancer characterized by a high incidence of liver and lymph node metastases, and a poor prognosis. Few advanced AFPGC cases treated successfully with conventional chemotherapy have been reported thus far. Although the development of molecular-targeted therapy has improved the prognosis of various types of cancer, there are currently no tailored therapies for AFPGC. In the present report, the case of a chemotherapy-resistant recurrent AFPGC patient who exhibited a significant response to ramucirumab monotherapy is presented...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28928806/alterations-in-iqgap1-expression-and-localization-in-colorectal-carcinoma-and-liver-metastases-following-oxaliplatin-based-chemotherapy
#12
Deborah Rotoli, Manuel Morales, María Del Carmen Maeso, María Del Pino García, Ricardo Gutierrez, Francisco Valladares, Julio Ávila, Lucio Díaz-Flores, Ali Mobasheri, Pablo Martín-Vasallo
IQGAP1 is a scaffolding protein that serves a key role in cell dynamics by integrating internal and external stimuli to distinct signal outputs. Previous studies have identified several genes that are significantly up- or downregulated in the peripheral white cells (PWCs) of patients with colorectal adenocarcinoma (CRC), who underwent oxaliplatin-based chemotherapy (CT). In addition, screening studies have reported that IQ-motif containing GTPase activating protein 1 (IQGAP1) transcriptional expression levels varied from 'off' to 'on' following oxaliplatin CT...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927777/the-role-of-cetuximab-in-converting-initially-unresectable-colorectal-cancer-liver-metastases-for-resection
#13
REVIEW
G Poston, R Adam, J Xu, B Byrne, R Esser, H Malik, H Wasan, J Xu
In patients with metastatic colorectal cancer (mCRC) predominantly confined to the liver, whether a patient undergoes potentially curative resection of the liver lesions is a well-established principal determinant of long-term survival. There are a number of different agents, both chemotherapeutic and targeted biologic agents, which can aid in shrinking liver tumors, which would have otherwise been unresectable, allowing for potentially curative resection. The aim of this review article is to summarize the available evidence regarding optimal therapeutic strategies for converting initially unresectable metastases for potentially curative resection; we do not discuss patients who present with initially resectable disease...
August 10, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28925798/laparoscopic-resections-of-colorectal-cancer-and-synchronous-liver-metastases-a-case-controlled-study
#14
Xiao Xu, Yulin Guo, Guijin Chen, Chen Li, Hongguang Wang, Guanglong Dong
PURPOSE: To investigate the efficacy and safety of laparoscopic simultaneous resections of colorectal cancer and synchronous colorectal liver metastases (SCRLM), relative to open surgery. METHODS: Between 1 January 2009 and 20 April 2014, 20 of 25 patients who underwent laparoscopic simultaneous colorectal cancer and SCRLM resections were matched with 20 of 29 patients who underwent an open approach, based on prognostic propensity scores. Perioperative results and survival outcomes were compared...
September 19, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/28923109/the-outcome-of-prostate-cancer-patients-treated-with-curative-intent-strongly-depends-on-survival-after-metastatic-progression
#15
Mariarosa Pascale, Che Ngwa Azinwi, Barbara Marongiu, Gianfranco Pesce, Flavio Stoffel, Enrico Roggero
BACKGROUND: Five-year survival in patients with localized prostate cancer (PCa) is nearly 100%, but metastatic disease still remains incurable. Clinical management of metastatic patients has become increasingly complex as novel therapeutic strategies have emerged. This study aims at evaluating the impact of the first metastatic progression on the outcome of PCa patients treated with curative intent. METHODS: The analysis was conducted using data of 913 cases of localized PCa diagnosed between 2000 and 2014...
September 18, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28922444/cholangiocarcinoma-in-wilson-s-disease-a-case-report
#16
Dániel Németh, Anikó Folhoffer, Gábor Smuk, Béla Kajtár, Tamás Tornóczky, Ferenc Szalay
It has been suggested that hepatobiliary carcinomas are less frequent in Wilson's disease (WD) than in liver diseases of other etiology. However, the protective role of copper against malignancies is debated. Only a few cases of cholangiocarcinoma (CCC) in WD have been published. Here we report on a case of a 47-year-old male H1069Q homozygous, Kayser-Fleischer ring positive WD patient with a low ceruloplasmin level who was followed up and treated with chelating agents throughout nine years. The patient presented with neurological symptoms and liver cirrhosis at diagnosis...
September 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28922441/evaluation-of-2d-shear-wave-elastography-for-characterisation-of-focal-liver-lesions
#17
Ludmila Gerber, Daniel Fitting, Kajana Srikantharajah, Nina Weiler, Georgia Kyriakidou, Joerg Bojunga, Falko Schulze, Dimitra Bon, Stefan Zeuzem, Mireen Friedrich-Rust
BACKGROUND AND AIM: This is a prospective study for evaluation of 2D-shear wave elastography (2D-SWE) for characterisation and differentiation of benign und malignant focal liver lesions (FLLs). METHODS: The patients referred to our ultrasound unit were prospectively included. B-mode ultrasound and 2D-SWE (Aixplorer® France) were performed for one FLL in each patient. Liver histology and/or contrast-enhanced imaging were used as a reference method. RESULTS: 140 patients with FLL were included...
September 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28921839/hepatoblastoma-in-children-aged-less-than-six-months-at-diagnosis-a-report-from-the-siopel-group
#18
Patrizia Dall'Igna, Laurence Brugieres, Anne Sanlaville Christin, Rudolf Maibach, Michela Casanova, Rita Alaggio, Jean de Ville de Goyet, Jozsef Zsiros, Bruce Morland, Piotr Czauderna, Margaret Childs, Daniel C Aronson, Sophie Branchereau, Penelope Brock, Giorgio Perilongo
BACKGROUND: The purpose of this study was to evaluate clinical characteristics, treatment, and survival of children, who were diagnosed with hepatoblastoma (HB) in their first 6 months of age, enrolled in the SIOPEL 2 and 3 protocols. METHODS: Seventy-nine patients, treated between 1994 and 2006, were analyzed after stratification into three age groups: <1 month, between 1 and 3 months, and between 3 and 6 months. All received preoperative chemotherapy. RESULTS: Clinical characteristics were similar in both trials: 4 patients had pulmonary metastases at diagnosis, 4 had α-fetoprotein <100 ng/ml, 68 were operated by partial hepatectomy, and 7 received liver transplant...
September 18, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28918830/metformin-has-positive-therapeutic-effects-in-colon-cancer-and-lung-cancer
#19
DeAnna Henderson, Danielle Frieson, Jeffrey Zuber, Solomon S Solomon
BACKGROUND: Metformin (MF), a diabetic drug, has antineoplastic activity as adjuvant therapy for breast cancer and prostate cancer. MF is thought to work via inhibition of mammalian target of rapamycin and activation of p53 and liver kinase B1 via adenosine 5'-monophosphate-activated protein kinase. We investigated survival, recurrences and metastasis in patients with type 2 diabetes mellitus (DM2) along with colorectal cancer (CC) or lung cancer (LC) taking MF using the electronic medical record in Memphis Veterans Affairs Medical Center (colon, n = 202; lung, n = 180)...
September 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28918405/renal-cell-carcinoma-with-isolated-metastasis-to-sigmoid-mesentery-a-rare-resectable-combination
#20
Hira Lal, Priyank Yadav, Shashidhar Achar, Uday Pratap Singh
Renal cell carcinoma accounts for 2%-3% of all malignancies in adults. It spreads via direct extension, lymphatic route as well as haematogenous route. Lymph nodes, lungs, bone, liver and brain are the usual sites for its metastatic spread. In the presence of limited metastatic disease with potentially resectable metastases, surgery offers the best chances of cure. In the present case, we describe a case of renal cell carcinoma with a solitary metastasis to the sigmoid mesentery in a patient with Von Hippel-Lindau syndrome...
September 15, 2017: BMJ Case Reports
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