Olivier Govaere, Sine Kragh Petersen, Nuria Martinez-Lopez, Jasper Wouters, Matthias Van Haele, Rosellina M Mancina, Oveis Jamialahmadi, Orsolya Bilkei-Gorzo, Pierre Bel Lassen, Rebecca Darlay, Julien Peltier, Jeremy M Palmer, Ramy Younes, Dina Tiniakos, Guruprasad P Aithal, Michael Allison, Michele Vacca, Melker Göransson, Rolando Berlinguer-Palmini, James E Clark, Michael J Drinnan, Hannele Yki-Järvinen, Jean-Francois Dufour, Mattias Ekstedt, Sven Francque, Salvatore Petta, Elisabetta Bugianesi, Jörn M Schattenberg, Christopher P Day, Heather J Cordell, Baki Topal, Karine Clément, Stefano Romeo, Vlad Ratziu, Tania Roskams, Ann K Daly, Quentin M Anstee, Matthias Trost, Anetta Härtlova
BACKGROUND & AIMS: Obesity-associated inflammation is a key player in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). However, the role of macrophage scavenger receptor 1 (MSR1, CD204) remains incompletely understood. METHODS: A total of 170 NAFLD liver biopsies were processed for transcriptomic analysis and correlated with clinicopathological features. Msr1-/- and wild-type mice were subjected to a 16-week high-fat and high-cholesterol diet. Mice and ex vivo human liver slices were treated with a monoclonal antibody against MSR1...
May 2022: Journal of Hepatology