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https://www.readbyqxmd.com/read/29771602/irisin-promotes-proliferation-but-inhibits-differentiation-in-osteoclast-precursor-cells
#1
Yaxian Ma, Xiaoyong Qiao, Rujun Zeng, Ran Cheng, Jun Zhang, Yunyao Luo, Ying Nie, Ying Hu, Zhilan Yang, Jing Zhang, Lin Liu, Wenming Xu, Charles C Xu, Liangzhi Xu
The receptor activator of NF-κB ligand-induced osteoclast differentiation has a critical role in the process of bone metabolism. Overactivation of osteoclastogenesis may result in a series of diseases. Irisin, a novel myokine, which was first reported in 2012, has been proposed to mediate the beneficial metabolic effects of exercise. Studies have demonstrated that irisin targets osteoblasts by promoting osteoblast proliferation and differentiation; however, the underlying mechanism regarding the effect of irisin on osteoclasts remains elusive...
May 17, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29729254/physical-exercise-reserved-amyloid-beta-induced-brain-dysfunctions-by-regulating-hippocampal-neurogenesis-and-inflammatory-response-via-mapk-signaling
#2
Li-Na Sun, Jin-Shun Qi, Rong Gao
Alzheimer's disease (AD) is one of the leading causes of dementia that induced by aggregation of amyloid-beta (Aβ) in brain tissue. With high structural and functional plasticity, hippocampus plays fundamental roles in cognitive regulation. Moreover, impaired hippocampal functions present during early onset of AD. Hence, targeting on improving hippocampal plasticity would be recognized as the effective strategy in AD therapy. Physical exercise is widely encouraged healthy life style. However, whether exercise could reserve the neural dysfunctions in AD model and the possible neurobiological mechanism still need for better understanding...
May 2, 2018: Brain Research
https://www.readbyqxmd.com/read/29695972/exercise-protects-against-defective-insulin-signaling-and-insulin-resistance-of-glucose-transport-in-skeletal-muscle-of-angiotensin-ii-infused-rat
#3
Juthamard Surapongchai, Yupaporn Rattanavichit, Jariya Buniam, Vitoon Saengsirisuwan
Objectives: The present study investigated the impact of voluntary exercise on insulin-stimulated glucose transport and the protein expression and phosphorylation status of the signaling molecules known to be involved in the glucose transport process in the soleus muscle as well as other cardiometabolic risks in a rat model with insulin resistance syndrome induced by chronic angiotensin II (ANGII) infusion. Materials and Methods: Male Sprague-Dawley rats were assigned to sedentary or voluntary wheel running (VWR) groups...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29673242/study-of-muscle-contraction-induced-by-electrical-pulse-stimulation-and-nitric-oxide-in-c2c12-myotube-cells
#4
In Ho Lee, Yoon Jeong Lee, Hyobin Seo, Yi Seul Kim, Ju-Ock Nam, Byung-Duk Jeon, Tae-Dong Kwon
PURPOSE: This study aimed to examine the independent effect of electrical pulse stimulation(EPS) and nitric oxide(NO) on muscle contraction and their synergistic or combined effect on contraction phenomenon using C2C12 mouse skeletal muscle cells. METHODS: Some differentiated C2C12 myotube cells were untreated (control). Other cells did not receive EPS and did receive 0.5, 1.0, or 2.0 mM of the NO donor, S-nitroso-N-acetyl-penicillamine (SNAP; -E/S0.5, -E/S1.0, and -E/S2...
March 30, 2018: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/29595913/past-injurious-exercise-attenuates-activation-of-primary-calcium-dependent-injury-pathways-in-skeletal-muscle-during-subsequent-exercise
#5
Ryo Takagi, Riki Ogasawara, Junya Takegaki, Yuki Tamura, Arata Tsutaki, Koichi Nakazato, Naokata Ishii
Past contraction-induced skeletal muscle injury reduces the degree of subsequent injury; this phenomenon is called the "repeated bout effect (RBE)." This study addresses the mechanisms underlying the RBE, focusing on primary calcium-dependent injury pathways. Wistar rats were subdivided into single injury (SI) and repeated injury (RI) groups. At age 10 weeks, the right gastrocnemius muscle in each rat in the RI group was subjected to strenuous eccentric contractions (ECs). Subsequently, mild ECs were imposed on the same muscle of each rat at 14 weeks of age in both groups...
March 2018: Physiological Reports
https://www.readbyqxmd.com/read/29498526/targeted-metabolomics-reveals-a-protective-role-for-basal-ppar%C3%AE-in-cholestasis-induced-by-%C3%AE-naphthylisothiocyanate
#6
Manyun Dai, Huiying Hua, Hante Lin, Gangming Xu, Xiaowei Hu, Fei Li, Frank J Gonzalez, Aiming Liu, Julin Yang
α-Naphthylisothiocyanate (ANIT) is an experimental agent used to induce intrahepatic cholestasis. The Ppara-null mouse line is widely employed to explore the physiological and pathological roles of PPARα. However, little is known about how PPARα influences the hepatotoxicity of ANIT. In the present study, wild-type and Ppara-null mice were orally treated with ANIT to induce cholestasis. The serum metabolome of wild-type mice segregated from that of the Ppara-null mice, driven by changes of bile acid (BA) metabolites...
April 6, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29466693/acute-extracellular-matrix-inflammatory-and-mapk-response-to-lengthening-contractions-in-elderly-human-skeletal-muscle
#7
Jacob R Sorensen, Caitlin Skousen, Alex Holland, Kyle Williams, Robert D Hyldahl
To uncover potential factors that may be involved in the impaired regenerative capacity of aged skeletal muscle, we comprehensively assessed the molecular stress response following muscle damage in old and young individuals. 10 young (22.7 ± 2.25 yrs) and 8 physically active old (70.9 ± 7.5 yrs) subjects completed a bout of 300 lengthening contractions (LC), and muscle biopsies were taken pre-exercise and at 3, 24, and 72 h post-LC. Both age groups performed the same amount of work during LC, with the old group displaying a resistance to LC-induced fatigue during the exercise...
June 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29380956/polyphenol-supplementation-alters-intramuscular-apoptotic-signaling-following-acute-resistance-exercise
#8
Jeremy R Townsend, Jeffrey R Stout, Adam R Jajtner, David D Church, Kyle S Beyer, Joshua J Riffe, Tyler W D Muddle, Kelli L Herrlinger, David H Fukuda, Jay R Hoffman
The purpose of this study was to examine the effects of 28-days of supplementation with an aqueous proprietary polyphenol blend (PPB) sourced from Camellia sinensis on intramuscular apoptotic signaling following an acute lower-body resistance exercise protocol and subsequent recovery. Untrained males (n = 38, 21.8 ± 2.7 years, 173.4 ± 7.9 cm, 77.6 ± 14.6 kg) were randomized to PPB (n = 14), placebo (PL; n = 14) or control (CON; n = 10). Participants completed a lower-body resistance exercise protocol comprised of the squat, leg press, and leg extension exercises...
January 2018: Physiological Reports
https://www.readbyqxmd.com/read/29298131/a-systematic-review-of-p53-regulation-of-oxidative-stress-in-skeletal-muscle
#9
Kaitlyn Beyfuss, David A Hood
BACKGROUND: p53 is a tumor suppressor protein involved in regulating a wide array of signaling pathways. The role of p53 in the cell is determined by the type of imposed oxidative stress, its intensity and duration. The last decade of research has unravelled a dual nature in the function of p53 in mediating the oxidative stress burden. However, this is dependent on the specific properties of the applied stress and thus requires further analysis. METHODS: A systematic review was performed following an electronic search of Pubmed, Google Scholar, and ScienceDirect databases...
December 2018: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/29234693/lean-and-obese-zucker-rat-extensor-digitorum-longus-muscle-high-frequency-electrical-stimulation-hfes-data-regulation-of-mapks-associated-proteins
#10
Kevin M Rice, Anjaiah Katta, Nandini D P K Manne, Ravikumar Arvapalli, Gautam K Ginjupalli, Miaozong Wu, Shinichi Asano, Eric R Blough
Anaerobic exercise has been advocated as a prescribed treatment for the management of diabetes: however, alterations in exercise-induced signaling remain largely unexplored in the diabetic muscle. Here, we compare the basal and the in situ contraction-induced phosphorylation of the mitogen-activated protein kinases (MAPKs) ERK 1/2, p38, and JNK in the lean and obese (fa/fa) Zucker rat extensor digitorum longus (EDL) muscle following a single bout of contractile stimuli. This article represents data associated with prior publications from our (Katta et al...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29234691/diabetic-zucker-rat-tibialis-anterior-muscle-high-frequency-electrical-stimulation-hfes-data-regulation-of-mapks-associated-proteins
#11
Gautam K Ginjupalli, Kevin M Rice, Anjaiah Katta, Nandini D P K Manne, Ravikumar Arvapalli, Miaozong Wu, Shinichi Asano, Eric R Blough
Anaerobic exercise has been advocated as a prescribed treatment for the management of diabetes: however, alterations in exercise-induced signaling remain largely unexplored in the diabetic muscle. Here, we compare the basal and the in situ contraction-induced phosphorylation of the mitogen-activated protein kinases (MAPKs) ERK 1/2, p38, and JNK in the lean and obese (fa/fa) Zucker rat tibialus anterior (TA) muscle following a single bout of contractile stimuli. This article represents data associated with prior publications from our lab (Katta et al...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/28843495/high-intensity-interval-versus-moderate-intensity-continuous-training-superior-metabolic-benefits-in-diet-induced-obesity-mice
#12
Ningning Wang, Yang Liu, Yanan Ma, Deliang Wen
AIMS: Exercise is beneficial in obesity, however, the debate about the value of high-intensity interval training (HIIT) vs. moderate-intensity continuous training (MICT) has been long lasting. Therefore, here we have compared the possible beneficial effects of two different exercise training regimes in a mouse model of diet-induced obesity (DIO). MATERIALS AND METHODS: Following 7wk. on high fat diet (HFD), ten-week-old male ICR mice (n=30) were assigned to HIIT, distance-matched MICT or remained sedentary for the next 8 constitutive weeks while maintaining the dietary treatments...
December 15, 2017: Life Sciences
https://www.readbyqxmd.com/read/28732805/capillarisin-attenuates-exercise-induced-muscle-damage-through-mapk-and-nf-%C3%AE%C2%BAb-signaling
#13
Minjee Kim, Jaemoo Chun, Hyun Ah Jung, Jae Sue Choi, Yeong Shik Kim
BACKGROUND: Intense exercise has the potential to increase oxidative stress and cause muscle damage. Mitogen-activated protein kinases (MAPKs) and nuclear factor-κB (NF-κB) are two major regulators of gene transcription in response to oxidative stress in the skeletal muscle. Pure capillarisin (CAP) isolated from Artemisia capillaris Thunberg is known to have antioxidant and anti-inflammatory effects. HYPOTHESIS/PURPOSE: We hypothesized CAP to exert antioxidant activity against exercise-induced oxidative stress and suppress acute inflammatory response...
August 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28689678/exercise-intensity-dependent-alterations-in-plasma-redox-status-do-not-reflect-skeletal-muscle-redox-sensitive-protein-signaling
#14
RANDOMIZED CONTROLLED TRIAL
Lewan Parker, Adam Trewin, Itamar Levinger, Christopher S Shaw, Nigel K Stepto
OBJECTIVES: Redox homeostasis and redox-sensitive protein signaling play a role in exercise-induced adaptation. The effects of sprint-interval exercise (SIE), high-intensity interval exercise (HIIE) and continuous moderate-intensity exercise (CMIE), on post-exercise plasma redox status are unclear. Furthermore, whether post-exercise plasma redox status reflects skeletal muscle redox-sensitive protein signaling is unknown. DESIGN: In a randomized crossover design, eight healthy adults performed a cycling session of HIIE (5×4min at 75% Wmax ), SIE (4×30s Wingate's), and CMIE work-matched to HIIE (30min at 50% of Wmax )...
April 2018: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28640248/voluntary-distance-running-prevents-tnf-mediated-liver-injury-in-mice-through-alterations-of-the-intrahepatic-immune-milieu
#15
Yvonne Huber, Nadine Gehrke, Jana Biedenbach, Susanne Helmig, Perikles Simon, Beate K Straub, Ina Bergheim, Tobias Huber, Detlef Schuppan, Peter R Galle, Marcus A Wörns, Marcus Schuchmann, Jörn M Schattenberg
Physical activity confers a broad spectrum of health benefits. Beyond the obvious role in metabolically driven diseases, the role of physical activity in acute liver injury is poorly explored. To study the role of physical activity in acute liver injury, a novel model of voluntary distance running in mice was developed and mice were subjected to acute liver injury induced by N-galactosamine (GalN) and lipopolysaccharide (LPS). Analyses included histological stains, immunoblotting, qRT-PCR and FACS analysis...
June 22, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28638919/-analyses-of-exercise-induced-muscle-damage-specific-microrna-expression-and-molecular-target-of-sarcolemmal-damage-in-rats
#16
Yu-Ming Xu, Jian-Min Cao, Jun-Ping Li, Qiao-Ting Huang, Ping Wang
In the present study, we were to screen the specific microRNA (miRNA) of exercise-induced muscle damage (EIMD) and assess the EIMD-specific miRNAs-regulated target of sarcolemmal damage in rats. Twenty-four male Sprague-Dawley (SD) rats were randomly divided into 3 groups, which included sedentary (C), 24 h post-exercise (E24) and 48 h post-exercise (E48) groups. Rat EIMD model was established by an acute eccentric exercise, i.e., a downhill running treatment at -16º gradient. EIMD characteristics were verified by Evans blue dye staining, differentially expressed miRNAs were detected by microarray assay, EIMD-specific miRNAs expressions were further validated by real-time quantitative RT-PCR (RT-qPCR), and targets of the miRNAs were predicted based on mRNA expressions of associated proteins and related pathway core molecules of sarcolemmal damage...
June 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28534952/effects-of-exercise-on-mature-or-precursor-brain%C3%A2-derived-neurotrophic-factor-pathways-in-ovariectomized-rats
#17
Joon-Ki Park, Young-Pyo Hong, Sam-Jun Lee
Ovariectomy (OVX) is a method used to block estrogen in female rats that induces hippocampal dysfunction and affects brain‑derived neurotrophic factor (BDNF) pathways. The majority of previous studies investigating OVX focused on BDNF expression in the hippocampus and cognitive function. The present study focused on the pathways of each BDNF type, precursor (proBDNF) and mature (mBDNF), and the effects of regular exercise in the hippocampus of ovariectomized rats. Female Sprague‑Dawely rats were used and OVX surgery was performed...
July 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28182793/the-effect-of-exercise-intensity-on-skeletal-muscle-stress-kinase-and-insulin-protein-signaling
#18
RANDOMIZED CONTROLLED TRIAL
Lewan Parker, Adam Trewin, Itamar Levinger, Christopher S Shaw, Nigel K Stepto
BACKGROUND: Stress and mitogen activated protein kinase (SAPK) signaling play an important role in glucose homeostasis and the physiological adaptation to exercise. However, the effects of acute high-intensity interval exercise (HIIE) and sprint interval exercise (SIE) on activation of these signaling pathways are unclear. METHODS: Eight young and recreationally active adults performed a single cycling session of HIIE (5 x 4 minutes at 75% Wmax), SIE (4 x 30 second Wingate sprints), and continuous moderate-intensity exercise work-matched to HIIE (CMIE; 30 minutes at 50% of Wmax), separated by a minimum of 1 week...
2017: PloS One
https://www.readbyqxmd.com/read/28039193/short-term-intense-exercise-training-reduces-stress-markers-and-alters-the-transcriptional-response-to-exercise-in-skeletal-muscle
#19
J Matthew Hinkley, Adam R Konopka, Miranda K Suer, Matthew P Harber
The purpose of this investigation was to examine the influence of short-term intense endurance training on cycling performance, along with the acute and chronic signaling responses of skeletal muscle stress and stability markers. Ten recreationally active subjects (25 ± 2 yr, 79 ± 3 kg, 47 ± 2 ml·kg-1 ·min-1 ) were studied before and after a 12-day cycling protocol to examine the effects of short-term intense (70-100% V̇o2max ) exercise training on resting and exercise-induced regulation of molecular factors related to skeletal muscle cellular stress and protein stability...
March 1, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27918079/high-intensity-treadmill-running-impairs-cognitive-behavior-and-hippocampal-synaptic-plasticity-of-rats-via-activation-of-inflammatory-response
#20
Li-Na Sun, Xiao-Long Li, Fei Wang, Jun Zhang, Dan-Dan Wang, Li Yuan, Mei-Na Wu, Zhao-Jun Wang, Jin-Shun Qi
Although appropriate exercise is beneficial for enhancing brain functions, high-intensity exercise (HIE)-induced cognitive dysfunction is causing more and more concerns nowadays. In the present study, we observed the effects of high-intensity treadmill running on the spatial learning of the adult Sprague Dawley male rats in Y-maze (n = 16 per group), and investigated its possible electrophysiological and molecular mechanisms by examining in vivo hippocampal long-term potentiation (LTP), central inflammatory responses, and JNK/p38/ERK signal pathway...
December 5, 2016: Journal of Neuroscience Research
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