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https://www.readbyqxmd.com/read/28843495/high-intensity-interval-versus-moderate-intensity-continuous-training-superior-metabolic-benefits-in-diet-induced-obesity-mice
#1
Ningning Wang, Yang Liu, Yanan Ma, Deliang Wen
AIMS: Exercise is beneficial in obesity, however, the debate about the value of high-intensity interval training (HIIT) vs. moderate-intensity continuous training (MICT) has been long lasting. Therefore, here we have compared the possible beneficial effects of two different exercise training regimes in a mouse model of diet-induced obesity (DIO). MATERIALS AND METHODS: Following 7wk. on high fat diet (HFD), ten-week-old male ICR mice (n=30) were assigned to HIIT, distance-matched MICT or remained sedentary for the next 8 constitutive weeks while maintaining the dietary treatments...
August 23, 2017: Life Sciences
https://www.readbyqxmd.com/read/28732805/capillarisin-attenuates-exercise-induced-muscle-damage-through-mapk-and-nf-%C3%AE%C2%BAb-signaling
#2
Minjee Kim, Jaemoo Chun, Hyun Ah Jung, Jae Sue Choi, Yeong Shik Kim
BACKGROUND: Intense exercise has the potential to increase oxidative stress and cause muscle damage. Mitogen-activated protein kinases (MAPKs) and nuclear factor-κB (NF-κB) are two major regulators of gene transcription in response to oxidative stress in the skeletal muscle. Pure capillarisin (CAP) isolated from Artemisia capillaris Thunberg is known to have antioxidant and anti-inflammatory effects. HYPOTHESIS/PURPOSE: We hypothesized CAP to exert antioxidant activity against exercise-induced oxidative stress and suppress acute inflammatory response...
August 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28689678/exercise-intensity-dependent-alterations-in-plasma-redox-status-do-not-reflect-skeletal-muscle-redox-sensitive-protein-signaling
#3
Lewan Parker, Adam Trewin, Itamar Levinger, Christopher S Shaw, Nigel K Stepto
OBJECTIVES: Redox homeostasis and redox-sensitive protein signaling play a role in exercise-induced adaptation. The effects of sprint-interval exercise (SIE), high-intensity interval exercise (HIIE) and continuous moderate-intensity exercise (CMIE), on post-exercise plasma redox status are unclear. Furthermore, whether post-exercise plasma redox status reflects skeletal muscle redox-sensitive protein signaling is unknown. DESIGN: In a randomized crossover design, eight healthy adults performed a cycling session of HIIE (5×4min at 75% Wmax), SIE (4×30s Wingate's), and CMIE work-matched to HIIE (30min at 50% of Wmax)...
July 1, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28640248/voluntary-distance-running-prevents-tnf-mediated-liver-injury-in-mice-through-alterations-of-the-intrahepatic-immune-milieu
#4
Yvonne Huber, Nadine Gehrke, Jana Biedenbach, Susanne Helmig, Perikles Simon, Beate K Straub, Ina Bergheim, Tobias Huber, Detlef Schuppan, Peter R Galle, Marcus A Wörns, Marcus Schuchmann, Jörn M Schattenberg
Physical activity confers a broad spectrum of health benefits. Beyond the obvious role in metabolically driven diseases, the role of physical activity in acute liver injury is poorly explored. To study the role of physical activity in acute liver injury, a novel model of voluntary distance running in mice was developed and mice were subjected to acute liver injury induced by N-galactosamine (GalN) and lipopolysaccharide (LPS). Analyses included histological stains, immunoblotting, qRT-PCR and FACS analysis...
June 22, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28638919/-analyses-of-exercise-induced-muscle-damage-specific-microrna-expression-and-molecular-target-of-sarcolemmal-damage-in-rats
#5
Yu-Ming Xu, Jian-Min Cao, Jun-Ping Li, Qiao-Ting Huang, Ping Wang
In the present study, we were to screen the specific microRNA (miRNA) of exercise-induced muscle damage (EIMD) and assess the EIMD-specific miRNAs-regulated target of sarcolemmal damage in rats. Twenty-four male Sprague-Dawley (SD) rats were randomly divided into 3 groups, which included sedentary (C), 24 h post-exercise (E24) and 48 h post-exercise (E48) groups. Rat EIMD model was established by an acute eccentric exercise, i.e., a downhill running treatment at -16º gradient. EIMD characteristics were verified by Evans blue dye staining, differentially expressed miRNAs were detected by microarray assay, EIMD-specific miRNAs expressions were further validated by real-time quantitative RT-PCR (RT-qPCR), and targets of the miRNAs were predicted based on mRNA expressions of associated proteins and related pathway core molecules of sarcolemmal damage...
June 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28534952/effects-of-exercise-on-mature-or-precursor-brain%C3%A2-derived-neurotrophic-factor-pathways-in-ovariectomized-rats
#6
Joon-Ki Park, Young-Pyo Hong, Sam-Jun Lee
Ovariectomy (OVX) is a method used to block estrogen in female rats that induces hippocampal dysfunction and affects brain‑derived neurotrophic factor (BDNF) pathways. The majority of previous studies investigating OVX focused on BDNF expression in the hippocampus and cognitive function. The present study focused on the pathways of each BDNF type, precursor (proBDNF) and mature (mBDNF), and the effects of regular exercise in the hippocampus of ovariectomized rats. Female Sprague‑Dawely rats were used and OVX surgery was performed...
July 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28182793/the-effect-of-exercise-intensity-on-skeletal-muscle-stress-kinase-and-insulin-protein-signaling
#7
RANDOMIZED CONTROLLED TRIAL
Lewan Parker, Adam Trewin, Itamar Levinger, Christopher S Shaw, Nigel K Stepto
BACKGROUND: Stress and mitogen activated protein kinase (SAPK) signaling play an important role in glucose homeostasis and the physiological adaptation to exercise. However, the effects of acute high-intensity interval exercise (HIIE) and sprint interval exercise (SIE) on activation of these signaling pathways are unclear. METHODS: Eight young and recreationally active adults performed a single cycling session of HIIE (5 x 4 minutes at 75% Wmax), SIE (4 x 30 second Wingate sprints), and continuous moderate-intensity exercise work-matched to HIIE (CMIE; 30 minutes at 50% of Wmax), separated by a minimum of 1 week...
2017: PloS One
https://www.readbyqxmd.com/read/28039193/short-term-intense-exercise-training-reduces-stress-markers-and-alters-the-transcriptional-response-to-exercise-in-skeletal-muscle
#8
J Matthew Hinkley, Adam R Konopka, Miranda K Suer, Matthew P Harber
The purpose of this investigation was to examine the influence of short-term intense endurance training on cycling performance, along with the acute and chronic signaling responses of skeletal muscle stress and stability markers. Ten recreationally active subjects (25 ± 2 yr, 79 ± 3 kg, 47 ± 2 ml·kg(-1)·min(-1)) were studied before and after a 12-day cycling protocol to examine the effects of short-term intense (70-100% V̇o2max) exercise training on resting and exercise-induced regulation of molecular factors related to skeletal muscle cellular stress and protein stability...
March 1, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27918079/high-intensity-treadmill-running-impairs-cognitive-behavior-and-hippocampal-synaptic-plasticity-of-rats-via-activation-of-inflammatory-response
#9
Li-Na Sun, Xiao-Long Li, Fei Wang, Jun Zhang, Dan-Dan Wang, Li Yuan, Mei-Na Wu, Zhao-Jun Wang, Jin-Shun Qi
Although appropriate exercise is beneficial for enhancing brain functions, high-intensity exercise (HIE)-induced cognitive dysfunction is causing more and more concerns nowadays. In the present study, we observed the effects of high-intensity treadmill running on the spatial learning of the adult Sprague Dawley male rats in Y-maze (n = 16 per group), and investigated its possible electrophysiological and molecular mechanisms by examining in vivo hippocampal long-term potentiation (LTP), central inflammatory responses, and JNK/p38/ERK signal pathway...
December 5, 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27771800/changes-in-resting-mitogen-activated-protein-kinases-following-resistance-exercise-overreaching-and-overtraining
#10
Justin X Nicoll, Andrew C Fry, Andrew J Galpin, Adam J Sterczala, Donald B Thomason, Christopher A Moore, Lawrence W Weiss, Loren Z F Chiu
PURPOSE: Many physiological maladaptations persist after overreaching and overtraining resistance exercise (RE). However, no studies have investigated changes in mitogen-activated protein kinases (MAPK) after overtraining in humans, despite their critical role regulating exercise-induced muscular adaptations. The purpose of this study was to describe the changes in total and resting phosphorylation status of extracellular signal-regulated kinase 1/2 (ERK1/2), c-Jun NH2-terminal kinase (JNK) and p38-MAPK following a period of RE overreaching or overtraining...
December 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/27695421/acute-high-intensity-interval-exercise-induced-redox-signaling-is-associated-with-enhanced-insulin-sensitivity-in-obese-middle-aged-men
#11
Lewan Parker, Nigel K Stepto, Christopher S Shaw, Fabio R Serpiello, Mitchell Anderson, David L Hare, Itamar Levinger
Background: Obesity and aging are associated with increased oxidative stress, activation of stress and mitogen activated protein kinases (SAPK), and the development of insulin resistance and metabolic disease. In contrast, acute exercise also increases oxidative stress and SAPK signaling, yet is reported to enhance insulin sensitivity and reduce the risk of metabolic disease. This study explored this paradox by investigating the effect of a single session of high-intensity interval-exercise (HIIE) on redox status, muscle SAPK and insulin protein signaling in eleven middle-aged obese men...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27504150/hepatoprotective-effect-of-quercetin-on-endoplasmic-reticulum-stress-and-inflammation-after-intense-exercise-in-mice-through-phosphoinositide-3-kinase-and-nuclear-factor-kappa-b
#12
Yuhan Tang, Juan Li, Chao Gao, Yanyan Xu, Yanyan Li, Xiao Yu, Jing Wang, Liegang Liu, Ping Yao
The mechanisms underlying intense exercise-induced liver damage and its potential treatments remain unclear. We explored the hepatoprotection and mechanisms of quercetin, a naturally occurring flavonoid, in strenuous exercise-derived endoplasmic reticulum stress (ERS) and inflammation. Intense exercise (28 m/min at a 5° slope for 90 min) resulted in the leakage of aminotransferases in the BALB/C mice. The hepatic ultrastructural malformations and oxidative stress levels were attenuated by quercetin (100 mg/kg·bw)...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27487746/strength-training-prevents-hyperinsulinemia-insulin-resistance-and-inflammation-independent-of-weight-loss-in-fructose-fed-animals
#13
José D Botezelli, Andressa Coope, Ana C Ghezzi, Lucieli T Cambri, Leandro P Moura, Pedro P M Scariot, Rodrigo Stellzer Gaspar, Rania A Mekary, Eduardo Rochete Ropelle, José Rodrigo Pauli
The aim of this study was to compare the effects of aerobic, strength, and combined training on metabolic disorders induced by a fructose-rich diet. Wistar rats (120 days old) were randomized into five groups (n = 8-14): C (control diet and sedentary), F (fed the fructose-rich diet and sedentary), FA (fed the fructose-rich diet and subject to aerobic exercise), FS (fed the fructose-rich diet and subject to strength exercise), and FAS (fed the fructose-rich diet and subject to combined aerobic and strength exercises)...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27333913/intramuscular-mapk-signaling-following-high-volume-and-high-intensity-resistance-exercise-protocols-in-trained-men
#14
RANDOMIZED CONTROLLED TRIAL
Adam M Gonzalez, Jay R Hoffman, Jeremy R Townsend, Adam R Jajtner, Carleigh H Boone, Kyle S Beyer, Kayla M Baker, Adam J Wells, Gerald T Mangine, Edward H Robinson, David D Church, Leonardo P Oliveira, David H Fukuda, Jeffrey R Stout
PURPOSE: To examine the mitogen-activated protein kinase (MAPK) family of signaling proteins following typical high volume (HV) and high intensity (HI) lower body resistance exercise protocols in resistance-trained men. METHODS: Ten resistance-trained men (24.7 ± 3.4 year; 90.1 ± 11.3 kg; 176.0 ± 4.9 cm) performed each resistance exercise protocol in a random, counterbalanced order. The HV protocol utilized a load of 70 % 1-RM for sets of 10-12 repetitions with a 1-min rest period length between sets and exercises...
September 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/27259333/the-antioxidant-immunomodulatory-and-anti-inflammatory-activities-of-spirulina-an-overview
#15
REVIEW
Qinghua Wu, Lian Liu, Anca Miron, Blanka Klímová, Dan Wan, Kamil Kuča
Spirulina is a species of filamentous cyanobacteria that has long been used as a food supplement. In particular, Spirulina platensis and Spirulina maxima are the most important. Thanks to a high protein and vitamin content, Spirulina is used as a nutraceutical food supplement, although its other potential health benefits have attracted much attention. Oxidative stress and dysfunctional immunity cause many diseases in humans, including atherosclerosis, cardiac hypertrophy, heart failure, and hypertension. Thus, the antioxidant, immunomodulatory, and anti-inflammatory activities of these microalgae may play an important role in human health...
August 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27215802/a-diphenyl-diselenide-supplemented-diet-and-swimming-exercise-promote-neuroprotection-reduced-cell-apoptosis-and-glial-cell-activation-in-the-hypothalamus-of-old-rats
#16
Marlon R Leite, José L Cechella, Simone Pinton, Cristina W Nogueira, Gilson Zeni
Aging is a process characterized by deterioration of the homeostasis of various physiological systems; although being a process under influence of multiple factors, the mechanisms involved in aging are not well understood. Here we investigated the effect of a (PhSe)2-supplemented diet (1ppm, 4weeks) and swimming exercise (1% of body weight, 20min per day, 4weeks) on proteins related to glial cells activation, apoptosis and neuroprotection in the hypothalamus of old male Wistar rats (27month-old). Old rats had activation of astrocytes and microglia which was demonstrated by the increase in the levels of glial fibrillary acidic protein (GFAP) and ionized calcium-binding adaptor molecule 1 (Iba-1) in hypothalamus...
September 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/27192989/depot-specific-effects-of-treadmill-running-and-rutin-on-white-adipose-tissue-function-in-diet-induced-obese-mice
#17
COMPARATIVE STUDY
Neng Chen, Ting Lei, Lili Xin, Lingmei Zhou, Jinbo Cheng, Liqiang Qin, Shufen Han, Zhongxiao Wan
White adipose tissue (WAT) is a critical organ involved in regulating metabolic homeostasis under obese condition. Strategies that could positively affect WAT function would hold promise for fighting against obesity and its complications. The aim of the present study is to explore the effects of treadmill exercise training and rutin intervention on adipose tissue function from diet-induced obese (DIO) mice and whether fat depot-specific effects existed. In epididymal adipose tissue, high-fat diet (HFD) resulted in reduction in adiponectin mRNA expression, peroxisome proliferator-activated receptors (PPAR)-γ and DsbA-L protein expression, elevation in endoplasmic reticulum (ER) stress markers including 78 kDa glucose-regulated protein (GRP-78), C/EBP homologous protein (CHOP) and p-c-Jun N-terminal kinase (JNK)...
September 2016: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27101291/aerobic-exercise-augments-muscle-transcriptome-profile-of-resistance-exercise
#18
RANDOMIZED CONTROLLED TRIAL
Tommy R Lundberg, Rodrigo Fernandez-Gonzalo, Per A Tesch, Eric Rullman, Thomas Gustafsson
Recent reports suggest that aerobic exercise may boost the hypertrophic response to short-term resistance training. This study explored the effects of an acute aerobic exercise bout on the transcriptional response to subsequent resistance exercise. Ten moderately trained men performed ∼45 min cycling on one leg followed by 4 × 7 maximal knee extensions for each leg, 15 min later. Thus, one limb performed aerobic and resistance exercise (AE + RE) while the opposing leg did resistance exercise only (RE). Biopsies were obtained from the vastus lateralis muscle of each leg 3 h after the resistance exercise bout...
June 1, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/26796753/liver-kinase-b1-inhibits-the-expression-of-inflammation-related-genes-postcontraction-in-skeletal-muscle
#19
Ting Chen, Timothy M Moore, Mark T W Ebbert, Natalie L McVey, Steven R Madsen, David M Hallowell, Alexander M Harris, Robin E Char, Ryan P Mackay, Chad R Hancock, Jason M Hansen, John S Kauwe, David M Thomson
Skeletal muscle-specific liver kinase B1 (LKB1) knockout mice (skmLKB1-KO) exhibit elevated mitogen-activated protein kinase (MAPK) signaling after treadmill running. MAPK activation is also associated with inflammation-related signaling in skeletal muscle. Since exercise can induce muscle damage, and inflammation is a response triggered by damaged tissue, we therefore hypothesized that LKB1 plays an important role in dampening the inflammatory response to muscle contraction, and that this may be due in part to increased susceptibility to muscle damage with contractions in LKB1-deficient muscle...
April 15, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/26655383/%C3%AE-lipoic-acid-up-regulates-expression-of-peroxisome-proliferator-activated-receptor-%C3%AE-in-skeletal-muscle-involvement-of-the-jnk-signaling-pathway
#20
Anne-Sophie Rousseau, Brigitte Sibille, Joseph Murdaca, Isabelle Mothe-Satney, Paul A Grimaldi, Jaap G Neels
We hypothesized that α-lipoic acid (α-LA) might interact with the transcriptional control of peroxisome proliferator-activated receptor (PPAR)β in skeletal muscle. Molecular mechanisms were investigated using differentiated C2C12 myotubes treated with α-LA and/or PPARβ agonist GW0742. In vivo studies with 3-mo-old C57Bl6 mice were realized: voluntary wheel running (VWR) training (7 wk), and a 6 wk diet containing (or not) α-LA (0.25% wt/wt). This last condition was combined with (or not) 1 bout of treadmill exercise (18 m/min for 1 h)...
March 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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