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George Rahmani, Adrian McArdle, John L Kelly
No abstract text is available yet for this article.
November 2016: Medical Education
Pushpa Raj Joshi, Thekla Apitz, Stephan Zierz
During physical activity in McArdle patients, little or no lactate is released in the skeletal muscle. However, excessive ammonia production has frequently been reported in these patients. Production of ammonia is catalysed by AMP deaminase (AMPD) and adenylate kinase (AK). The activities of AMPD and AK along with housekeeping enzyme phosphoglucoisomerase (PGI) were measured in 11 genetically confirmed McArdle patients and compared with 27 healthy controls. The AMPD and AK activities were not significantly different in patients and controls...
October 20, 2016: Neurological Research
Joe McArdle, Georgie Tiller
No abstract text is available yet for this article.
October 2016: Journal of Paediatrics and Child Health
David J T McArdle, Felix L J Paterson, Lloyd L Morris
No abstract text is available yet for this article.
October 6, 2016: Journal of Pediatrics
David J T McArdle, Sumit J Karia
No abstract text is available yet for this article.
October 3, 2016: Practical Neurology
Giorgos K Sakellariou, Timothy Pearson, Adam P Lightfoot, Gareth A Nye, Nicola Wells, Ifigeneia I Giakoumaki, Aphrodite Vasilaki, Richard D Griffiths, Malcolm J Jackson, Anne McArdle
Age-related loss of skeletal muscle mass and function is a major contributor to morbidity and has a profound effect on the quality of life of older people. The potential role of age-dependent mitochondrial dysfunction and cumulative oxidative stress as the underlying cause of muscle aging remains a controversial topic. Here we show that the pharmacological attenuation of age-related mitochondrial redox changes in muscle with SS31 is associated with some improvements in oxidative damage and mitophagy in muscles of old mice...
September 29, 2016: Scientific Reports
K Foley, P Groome, D Feldman-Stewart, M Brundage, S McArdle, W MacKillop
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
See Yung Phang, Kathrin Whitehouse, Lucy Lee, Hisham Khalil, Paul McArdle, Peter C Whitfield
AIMS: CSF leaks are not uncommon after a base of skull fracture. Currently there is no standardised algorithm for the investigation and management of post-traumatic CSF leaks. In this paper we aim to provide an evidence-based framework for managing post-traumatic CSF leaks. METHODS: We searched the English literature over the past 45 years using CINAHL, EMBASE and MEDLINE for the terms (1) post-traumatic CSF leaks or fistulas, and (2) basilar or base of skull fractures, but excluded papers on post-operative and non-traumatic CSF leaks, and papers on paediatric post- traumatic CSF leaks...
September 26, 2016: British Journal of Neurosurgery
J Vissing
Metabolic myopathies encompass muscle glycogenoses (GSD) and disorders of muscle fat oxidation (FAOD). FAODs and GSDs can be divided into two main clinical phenotypes; those with static symptoms related to fixed muscle weakness and atrophy, and those with dynamic, exercise-related symptoms that are brought about by a deficient supply of ATP. Together with mitochondrial myopathies, metabolic myopathies are unique among muscle diseases, as the limitation in exercise performance is not solely caused by structural damage of muscle, but also or exclusively related to energy deficiency...
October 2016: Revue Neurologique
Patrick F McArdle
No abstract text is available yet for this article.
October 2016: Diabetes
David John Tobias McArdle, David Cottier, Anthony Beasley
No abstract text is available yet for this article.
2016: BMJ Case Reports
Miao Zhang, Ramesh R Chavan, Bronwen G Smith, Brian H McArdle, Philip J Harris
BACKGROUND: Compression wood (CW) forms on the underside of tilted stems of coniferous gymnosperms and opposite wood (OW) on the upperside. The tracheid walls of these wood types differ structurally and chemically. Although much is known about the most severe form of CW, severe CW (SCW), mild CWs (MCWs), also occur, but less is known about them. In this study, tracheid wall structures and compositions of two grades of MCWs (1 and 2) and SCW were investigated and compared with OW in slightly tilted radiata pine (Pinus radiata) stems...
2016: BMC Plant Biology
Zhichao Fan, Sara McArdle, Alex Marki, Zbigniew Mikulski, Edgar Gutierrez, Britta Engelhardt, Urban Deutsch, Mark Ginsberg, Alex Groisman, Klaus Ley
Neutrophils are essential for innate immunity and inflammation and many neutrophil functions are β2 integrin-dependent. Integrins can extend (E(+)) and acquire a high-affinity conformation with an 'open' headpiece (H(+)). The canonical switchblade model of integrin activation proposes that the E(+) conformation precedes H(+), and the two are believed to be structurally linked. Here we show, using high-resolution quantitative dynamic footprinting (qDF) microscopy combined with a homogenous conformation-reporter binding assay in a microfluidic device, that a substantial fraction of β2 integrins on human neutrophils acquire an unexpected E(-)H(+) conformation...
2016: Nature Communications
R Doug McEvoy, Nick A Antic, Emma Heeley, Yuanming Luo, Qiong Ou, Xilong Zhang, Olga Mediano, Rui Chen, Luciano F Drager, Zhihong Liu, Guofang Chen, Baoliang Du, Nigel McArdle, Sutapa Mukherjee, Manjari Tripathi, Laurent Billot, Qiang Li, Geraldo Lorenzi-Filho, Ferran Barbe, Susan Redline, Jiguang Wang, Hisatomi Arima, Bruce Neal, David P White, Ron R Grunstein, Nanshan Zhong, Craig S Anderson
Background Obstructive sleep apnea is associated with an increased risk of cardiovascular events; whether treatment with continuous positive airway pressure (CPAP) prevents major cardiovascular events is uncertain. Methods After a 1-week run-in period during which the participants used sham CPAP, we randomly assigned 2717 eligible adults between 45 and 75 years of age who had moderate-to-severe obstructive sleep apnea and coronary or cerebrovascular disease to receive CPAP treatment plus usual care (CPAP group) or usual care alone (usual-care group)...
September 8, 2016: New England Journal of Medicine
Antonio B Ward, Mary B Dail, Janice E Chambers
Organochlorine compounds (OC), such as the legacy insecticides, were widespread environmental contaminants. OC including dichlorodiphenyldichloroethylene (DDE), a metabolite of the insecticide DDT, have an epidemiological association with type 2 diabetes mellitus (T2D) and may play a role in risk factors that contribute to T2D such as dyslipidemia. The liver, a potential target for DDE, plays a role in dyslipidemia. The in vitro effect of DDE on hepatocyte lipid metabolism and secretion was investigated using McArdle-RH7777 (McA) rodent hepatoma liver cells...
December 2016: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Tom G Richardson, Hashem A Shihab, Gibran Hemani, Jie Zheng, Eilis Hannon, Jonathan Mill, Elena Carnero-Montoro, Jordana T Bell, Oliver Lyttleton, Wendy L McArdle, Susan M Ring, Santiago Rodriguez, Colin Campbell, George Davey Smith, Caroline L Relton, Nicholas J Timpson, Tom R Gaunt
BACKGROUND: Single variant approaches have been successful in identifying DNA methylation quantitative trait loci (mQTL), although as with complex traits they lack statistical power to identify effects from rare genetic variants. We have undertaken extensive analyses to identify regions of low frequency and rare variants that are associated with DNA methylation levels. METHODS: We used repeated measurements of DNA methylation from five different life stages in human blood, taken from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort...
August 24, 2016: Human Molecular Genetics
Santiago Rodriguez, Osama Al-Ghamdi, Philip Guthrie, Hashem Shihab, Wendy McArdle, Tom Gaunt, Khalid Alharbi, Ian Day
BACKGROUND: One of the kallikrein genes (KLK3) encodes Prostate Specific Antigen (PSA), a key biomarker for prostate cancer. A number of factors, both genetic and non-genetic, determine variation of serum PSA concentrations in the population. We have recently found three KLK3 deletions in individuals with very low PSA levels, suggesting a link between abnormally reduced KLK3 expression and deletions of KLK3 Here we aim to determine the frequency of kallikrein gene 3 deletions in the general population...
August 23, 2016: Annals of Clinical Biochemistry
Darragh S Gogarty, Paul Lennon, Sandra Deady, J Barry O'Sullivan, Orla McArdle, Mary Leader, Patrick Sheahan, James Paul O'Neill
This study aims to determine the survival impact of patient characteristics and treatment options associated with the early stage oral cavity squamous cell carcinoma, OCSCC. The methods are analysis of Irish cancer database examining T1/2, N0, and M0 cases of OCSCC from 1997 to 2007 inclusive. In total, 397 cases were identified. Anterolateral tongue accounted for 52.9 % of cases. Increased age at diagnosis and smoking are independent prognostic survival indicators associated with poorer outcomes. Surgery as the initial intervention was associated with significantly better survival outcomes, while surgery and adjuvant radiotherapy significantly worse outcomes...
August 23, 2016: European Archives of Oto-rhino-laryngology
Andrew J McArdle, James Webbe, Kathleen Sim, Graham Parrish, Clive Hoggart, Yifei Wang, J Simon Kroll, Sunit Godambe, Aubrey J Cunnington
Carboxyhemoglobin levels in blood reflect endogenous carbon monoxide production and are often measured during routine blood gas analysis. Endogenous carbon monoxide production has been reported to be increased during sepsis, but carboxyhemoglobin levels have not been thoroughly evaluated as a biomarker of sepsis. We sought to determine whether carboxyhemoglobin levels were elevated during sepsis in a high risk population of premature neonates. We conducted a retrospective cohort study of 30 infants in two neonatal intensive care units using electronic medical and laboratory records...
2016: PloS One
Giorgos K Sakellariou, Timothy Pearson, Adam P Lightfoot, Gareth A Nye, Nicola Wells, Ifigeneia I Giakoumaki, Richard D Griffiths, Anne McArdle, Malcolm J Jackson
Age-related skeletal muscle dysfunction is the underlying cause of morbidity that affects up to half the population aged 80 and over. Considerable evidence indicates that oxidative damage and mitochondrial dysfunction contribute to the sarcopenic phenotype that occurs with aging. To examine this, we administered the mitochondria-targeted antioxidant mitoquinone mesylate [[10-(4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)decyl] triphenylphosphonium; 100 μM] to wild-type C57BL/6 mice for 15 wk (from 24-28 mo of age) and investigated the effects on age-related loss of muscle mass and function, changes in redox homeostasis, and mitochondrial organelle integrity and function...
August 22, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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