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https://www.readbyqxmd.com/read/29350794/the-role-of-electrodiagnosis-with-long-exercise-test-in-mcardle-disease
#1
Claudio Semplicini, Marianne Hézode-Arzel, Pascal Laforêt, Anthony Béhin, Sarah Leonard-Louis, Jean-Yves Hogrel, François Petit, Bruno Eymard, Tanya Stojkovic, Emmanuel Fournier
INTRODUCTION: We evaluated the role of an electrodiagnsotic provocative test (long exercise test, LET) in McArdle disease. METHODS: Twenty-five McArdle patients and two control groups underwent an electrodiagnsotic protocol with LET, consisting of recording the compound muscle action potential (CMAP) before and after 5 minutes of isometric contraction. RESULTS: LET disclosed a post-exercise decrease in CMAP amplitude in 23/25 McArdle patients...
January 19, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29349670/working-longer-than-9-to-5-are-there-cardiometabolic-health-risks-for-young-australian-workers-who-report-longer-than-38-h-working-weeks
#2
Amy C Reynolds, Romola S Bucks, Jessica L Paterson, Sally A Ferguson, Trevor A Mori, Nigel McArdle, Leon Straker, Lawrence J Beilin, Peter R Eastwood
PURPOSE: The average Australian working week in middle-aged and older workers exceeds government recommendations. Long working weeks are associated with poor health outcomes; however, the relationship between long working weeks and health in young Australian workers is unknown. METHODS: Data were drawn from the 22-year follow-up of the Western Australian Pregnancy Cohort (Raine) Study in Perth, Western Australia. Information was available from 873 young adults about working hours per week, shift work and sleep duration...
January 18, 2018: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/29319554/intramedullary-sarcoidosis-mri-and-pet-diagnosis
#3
David J T McArdle, Sumit J Karia
No abstract text is available yet for this article.
January 9, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29315579/muscle-molecular-adaptations-to-endurance-exercise-training-are-conditioned-by-glycogen-availability-a-proteomics-based-analysis-in-the-mcardle-mouse-model
#4
Carmen Fiuza-Luces, Alejandro Santos-Lozano, Francisco Llavero, Rocío Campo, Gisela Nogales-Gadea, Jorge Díez Bermejo, Carlos Balandrón, África González-Murillo, Joaquín Arenas, Miguel A Martín, Antoni L Andreu, Tomàs Pinós, Beatriz G Gálvez, Juan A López, Jesús Vázquez, José L Zugaza, Alejandro Lucia
McArdle disease is an inborn disorder of skeletal muscle glycogen metabolism that results in blockade of glycogen breakdown due to mutations in the myophosphorylase gene. We recently developed a mouse model carrying the homozygous p.R50X common human mutation (McArdle mouse), facilitating the study of how glycogen availability affects muscle molecular adaptations to endurance exercise training. Using quantitative differential analysis by liquid chromatography with tandem-mass spectrometry, we analysed the quadriceps muscle proteome of 16-week-old McArdle (n = 5) and wild-type (WT) (n = 4) mice previously subjected to 8-week moderate-intensity treadmill training or to an equivalent control (no training) period...
January 7, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29315434/recognizable-clinical-subtypes-of-osa-across-a-worldwide-sleep-center-population-a-cluster-analysis
#5
Brendan T Keenan, Jinyoung Kim, Bhajan Singh, Lia Bittencourt, Ning-Hung Chen, Peter A Cistulli, Ulysses Magalang, Nigel McArdle, Jesse W Mindel, Bryndis Benediktsdottir, Erna Sif Arnardottir, Lisa Kristin Prochnow, Thomas Penzel, Bernd Sanner, Richard Schwab, Chol Shin, Kate Sutherland, Sergio Tufik, Greg Maislin, Thorarinn Gislason, Allan I Pack
Study Objectives: A recent study of moderate-severe obstructive sleep apnea (OSA) patients in Iceland identified 3 clinical clusters based on symptoms and comorbidities. We sought to verify this finding in a new cohort in Iceland and examine the generalizability of OSA clusters in an international ethnically diverse cohort. Methods: Using data on 972 moderate-severe OSA patients [apnea-hypopnea index (AHI) ≥15 events/hour] recruited from the Sleep Apnea Global Interdisciplinary Consortium (SAGIC) we performed a latent class analysis of 18 self-reported symptom variables, hypertension, cardiovascular disease and diabetes...
January 5, 2018: Sleep
https://www.readbyqxmd.com/read/29304317/strategies-to-improve-management-of-shoulder-dystocia-under-the-ahrq-safety-program-for-perinatal-care
#6
Jill McArdle, Asta Sorensen, Christina I Fowler, Samantha Sommerness, Katrina Burson, Leila Kahwati
OBJECTIVE: To assess implementation of safety strategies to improve management of births complicated by shoulder dystocia in labor and delivery units. DESIGN: Mixed-methods implementation evaluation. SETTING/LOCAL PROBLEM: Labor and delivery units (N = 18) in 10 states participating in the Safety Program for Perinatal Care (SPPC). Shoulder dystocia is unpredictable, requiring rapid and coordinated action. PARTICIPANTS: Key informants were labor and delivery unit staff who implemented SPPC safety strategies...
January 2, 2018: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/29300105/misspecification-in-latent-change-score-models-consequences-for-parameter-estimation-model-evaluation-and-predicting-change
#7
D Angus Clark, Amy K Nuttall, Ryan P Bowles
Latent change score models (LCS) are conceptually powerful tools for analyzing longitudinal data (McArdle & Hamagami, 2001). However, applications of these models typically include constraints on key parameters over time. Although practically useful, strict invariance over time in these parameters is unlikely in real data. This study investigates the robustness of LCS when invariance over time is incorrectly imposed on key change-related parameters. Monte Carlo simulation methods were used to explore the impact of misspecification on parameter estimation, predicted trajectories of change, and model fit in the dual change score model, the foundational LCS...
January 4, 2018: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/29290407/expanding-access-to-clinical-services-for-toddlers-with-autism-spectrum-disorders
#8
Therese L Mathews, Ashley M Lugo, Melissa L King, Laura L Needelman, Paige E McArdle, Natalie Romer, Megan Terry, Kathryn Menousek, Joseph H Evans, William J Higgins
Autism spectrum disorder (ASD) is a neurodevelopmental disorder typically diagnosed in the toddler and preschool years. Intensive early intervention (EI) using applied behavior analytic procedures is the evidenced-based intervention most effective in improving developmental outcomes. Unfortunately, there are numerous barriers to accessing EI services for toddlers with ASD. This article addresses (a) the process of developing an EI program using primarily applied behavior analytic services with multidisciplinary health care providers, (b) a description of the service delivery provided, (c) educational and training programs to increase qualified staff, and (d) advocacy efforts to improve community capacity...
December 28, 2017: Journal of Pediatric Health Care
https://www.readbyqxmd.com/read/29281835/effector-and-regulatory-t-cells-roll-at-high-shear-stress-by-inducible-tether-and-sling-formation
#9
Michael Abadier, Akula Bala Pramod, Sara McArdle, Alex Marki, Zhichao Fan, Edgar Gutierrez, Alex Groisman, Klaus Ley
The adaptive immune response involves T cell differentiation and migration to sites of inflammation. T cell trafficking is initiated by rolling on inflamed endothelium. Tethers and slings, discovered in neutrophils, facilitate cell rolling at high shear stress. Here, we demonstrate that the ability to form tethers and slings during rolling is highly inducible in T helper 1 (Th1), Th17, and regulatory T (Treg) cells but less in Th2 cells. In vivo, endogenous Treg cells rolled stably in cremaster venules at physiological shear stress...
December 26, 2017: Cell Reports
https://www.readbyqxmd.com/read/29280509/screening-for-mental-health-needs-of-new-zealand-youth-in-secure-care-facilities-using-the-maysi-2
#10
Sean McArdle, Ian Lambie
BACKGROUND: Young people admitted to secure facilities generally have particularly high rates of mental, emotional and behavioural problems, but little is known about the mental health needs of this group in New Zealand. AIMS: To describe prevalence of probable mental health disorder and related needs among young people in secure facilities in New Zealand. METHODS: Massachusetts youth screening instrument - second version (MAYSI-2) data were obtained from the records of young people admitted to one secure care facility (n = 204) within a 12 month period...
December 27, 2017: Criminal Behaviour and Mental Health: CBMH
https://www.readbyqxmd.com/read/29276846/parents-experiences-of-health-services-for-the-treatment-of-eating-disorders-a-qualitative-study
#11
Siobhain McArdle
BACKGROUND: The importance of involving parents in the treatment of eating disorders is widely recognised, however despite this, very little research has explored parents' perspectives of services. AIMS: This study aimed to explore parents' experiences following contact with services for the treatment of their child's eating disorder. METHODS: Employing qualitative methodology, 15 parents who had experience of health care services for the treatment of their daughter's eating disorder participated in either focus group or individual semi-structured interviews...
December 23, 2017: Journal of Mental Health
https://www.readbyqxmd.com/read/29273806/multiancestry-association-study-identifies-new-asthma-risk-loci-that-colocalize-with-immune-cell-enhancer-marks
#12
Florence Demenais, Patricia Margaritte-Jeannin, Kathleen C Barnes, William O C Cookson, Janine Altmüller, Wei Ang, R Graham Barr, Terri H Beaty, Allan B Becker, John Beilby, Hans Bisgaard, Unnur Steina Bjornsdottir, Eugene Bleecker, Klaus Bønnelykke, Dorret I Boomsma, Emmanuelle Bouzigon, Christopher E Brightling, Myriam Brossard, Guy G Brusselle, Esteban Burchard, Kristin M Burkart, Andrew Bush, Moira Chan-Yeung, Kian Fan Chung, Alexessander Couto Alves, John A Curtin, Adnan Custovic, Denise Daley, Johan C de Jongste, Blanca E Del-Rio-Navarro, Kathleen M Donohue, Liesbeth Duijts, Celeste Eng, Johan G Eriksson, Martin Farrall, Yuliya Fedorova, Bjarke Feenstra, Manuel A Ferreira, Maxim B Freidin, Zofia Gajdos, Jim Gauderman, Ulrike Gehring, Frank Geller, Jon Genuneit, Sina A Gharib, Frank Gilliland, Raquel Granell, Penelope E Graves, Daniel F Gudbjartsson, Tari Haahtela, Susan R Heckbert, Dick Heederik, Joachim Heinrich, Markku Heliövaara, John Henderson, Blanca E Himes, Hiroshi Hirose, Joel N Hirschhorn, Albert Hofman, Patrick Holt, Jouke Hottenga, Thomas J Hudson, Jennie Hui, Medea Imboden, Vladimir Ivanov, Vincent W V Jaddoe, Alan James, Christer Janson, Marjo-Riitta Jarvelin, Deborah Jarvis, Graham Jones, Ingileif Jonsdottir, Pekka Jousilahti, Michael Kabesch, Mika Kähönen, David B Kantor, Alexandra S Karunas, Elza Khusnutdinova, Gerard H Koppelman, Anita L Kozyrskyj, Eskil Kreiner, Michiaki Kubo, Rajesh Kumar, Ashish Kumar, Mikko Kuokkanen, Lies Lahousse, Tarja Laitinen, Catherine Laprise, Mark Lathrop, Susanne Lau, Young-Ae Lee, Terho Lehtimäki, Sébastien Letort, Albert M Levin, Guo Li, Liming Liang, Laura R Loehr, Stephanie J London, Daan W Loth, Ani Manichaikul, Ingo Marenholz, Fernando J Martinez, Melanie C Matheson, Rasika A Mathias, Kenji Matsumoto, Hamdi Mbarek, Wendy L McArdle, Mads Melbye, Erik Melén, Deborah Meyers, Sven Michel, Hamida Mohamdi, Arthur W Musk, Rachel A Myers, Maartje A E Nieuwenhuis, Emiko Noguchi, George T O'Connor, Ludmila M Ogorodova, Cameron D Palmer, Aarno Palotie, Julie E Park, Craig E Pennell, Göran Pershagen, Alexey Polonikov, Dirkje S Postma, Nicole Probst-Hensch, Valery P Puzyrev, Benjamin A Raby, Olli T Raitakari, Adaikalavan Ramasamy, Stephen S Rich, Colin F Robertson, Isabelle Romieu, Muhammad T Salam, Veikko Salomaa, Vivi Schlünssen, Robert Scott, Polina A Selivanova, Torben Sigsgaard, Angela Simpson, Valérie Siroux, Lewis J Smith, Maria Solodilova, Marie Standl, Kari Stefansson, David P Strachan, Bruno H Stricker, Atsushi Takahashi, Philip J Thompson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Carla M T Tiesler, Dara G Torgerson, Tatsuhiko Tsunoda, André G Uitterlinden, Ralf J P van der Valk, Amaury Vaysse, Sailaja Vedantam, Andrea von Berg, Erika von Mutius, Judith M Vonk, Johannes Waage, Nick J Wareham, Scott T Weiss, Wendy B White, Magnus Wickman, Elisabeth Widén, Gonneke Willemsen, L Keoki Williams, Inge M Wouters, James J Yang, Jing Hua Zhao, Miriam F Moffatt, Carole Ober, Dan L Nicolae
We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases...
January 2018: Nature Genetics
https://www.readbyqxmd.com/read/29259507/management-of-chronic-venous-disease
#13
Michael McArdle, Eduardo A Hernandez-Vila
No abstract text is available yet for this article.
October 2017: Texas Heart Institute Journal
https://www.readbyqxmd.com/read/29251685/a-new-condition-in-mcardle-disease-poor-bone-health-benefits-of-an-active-lifestyle
#14
Irene Rodríguez-Gómez, Alfredo Santalla, Jorge Díez-Bermejo, Diego Munguía-Izquierdo, Luis M Alegre, Gisela Nogales-Gadea, Joaquin Arenas, Miguel Ángel Martín, Alejandro Lucía, Ignacio Ara
INTRODUCTION-PURPOSE: McArdle disease (muscle glycogen phosphorylase deficiency) is a genetic condition associated with exercise intolerance, but how it affects lean mass (LM) and bone mineral content (BMC) and density (BMD) in patients is unknown. We compared these variables between McArdle patients and age-/sex-matched healthy controls and assessed their potential association with physical activity levels in patients. METHODS: A case-control, cross-sectional design was used to examine LM, BMC, and BMD by using dual-energy x-ray absorptiometry in 136 young adults of both sexes (36 McArdle patients (33 ± 15 yr) and 103 controls (34 ± 11 yr))...
January 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29235315/design-enhances-soft-tissue-architecture
#15
Barry F McArdle
No abstract text is available yet for this article.
April 2017: Dentistry Today
https://www.readbyqxmd.com/read/29225453/a-comparison-of-methods-for-uncovering-sample-heterogeneity-structural-equation-model-trees-and-finite-mixture-models
#16
Ross Jacobucci, Kevin J Grimm, John J McArdle
Although finite mixture models have received considerable attention, particularly in the social and behavioral sciences, an alternative method for creating homogeneous groups, structural equation model trees (Brandmaier, von Oertzen, McArdle, & Lindenberger, 2013), is a recent development that has received much less application and consideration. It is our aim to compare and contrast these methods for uncovering sample heterogeneity. We illustrate the use of these methods with longitudinal reading achievement data collected as part of the Early Childhood Longitudinal Study-Kindergarten Cohort...
2017: Structural Equation Modeling: a Multidisciplinary Journal
https://www.readbyqxmd.com/read/29214135/developing-procedures-to-improve-therapist-child-rapport-in-early-intervention
#17
Ashley M Lugo, Melissa L King, John C Lamphere, Paige E McArdle
Rapport is a primary component in the development of a therapeutic relationship between health-service professionals and clients. Presession pairing is a procedure often recommended in behavior analytic practice to build rapport with clients. However, many service providers may not exhibit presession pairing skills correctly or at a sufficient rate. The current study aimed to operationally define therapist behaviors that are indicative of presession pairing and to train direct care staff to implement said skills...
December 2017: Behavior Analysis in Practice
https://www.readbyqxmd.com/read/29191998/is-the-packed-cell-volume-%C3%A3-3-rule-valid-for-estimating-haemoglobin-in-children-in-malarious-areas
#18
Wilma Francisca Tanga, Andrew James McArdle
No abstract text is available yet for this article.
November 30, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29178179/multimodal-imaging-of-posterior-ocular-involvement-in-mcardle-s-disease
#19
Giuseppe Casalino, Wing Chan, Clara McAvoy, Michele Coppola, Francesco Bandello, Alan C Bird, Usha Chakravarthy
No abstract text is available yet for this article.
November 26, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/29174367/exercising-with-blocked-muscle-glycogenolysis-adaptation-in-the-mcardle-mouse
#20
Tue L Nielsen, Tomàs Pinós, Astrid Brull, John Vissing, Thomas O Krag
BACKGROUND: McArdle disease (glycogen storage disease type V) is an inborn error of skeletal muscle metabolism, which affects glycogen phosphorylase (myophosphorylase) activity leading to an inability to break down glycogen. Patients with McArdle disease are exercise intolerant, as muscle glycogen-derived glucose is unavailable during exercise. Metabolic adaptation to blocked muscle glycogenolysis occurs at rest in the McArdle mouse model, but only in highly glycolytic muscle. However, it is unknown what compensatory metabolic adaptations occur during exercise in McArdle disease...
November 21, 2017: Molecular Genetics and Metabolism
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