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JOURNAL ARTICLE
Emily J Swaby, Angela L Coe, Jörg Ansorge, Bryony A Caswell, Scott A L Hayward, Luke Mander, Liadan G Stevens, Aimee McArdle
Extreme global warming and environmental changes associated with the Toarcian (Lower Jurassic) Oceanic Anoxic Event (T-OAE, ~183 Mya) profoundly impacted marine organisms and terrestrial plants. Despite the exceptionally elevated abundances of fossil insects from strata of this age, only assemblages from Germany and Luxembourg have been studied in detail. Here, we focus on the insect assemblage found in strata recording the T-OAE at Alderton Hill, Gloucestershire, UK, where <15% of specimens have previously been described...
2024: PloS One
#2
JOURNAL ARTICLE
Lamis Alaa Eldin Refat, Jolanta Karpinska, Saidulu Konda, John M Simmie, Paul Vincent Murphy, Patrick McArdle, Andrea Erxleben
The solvent-free elimination of sulfinic acid and aromatization of 1,6-trans-substituted bis(arylsulfone) trienes is reported. It is shown that sublimation can be used as a 'green' method to combine the thermal transformation of six trienes and the crystal growth of the resulting 4-(phenylsulfonyl)biphenyls. When the sublimation conditions are carefully controlled, high quality single crystals of the 4-(phenylsulfonyl)biphenyls are obtained. Theoretical modelling of the reaction using the simplified triene Ph-(CH)6-SO2H showed that the cyclization is energetically feasible and that the complete conversion is possible during the timescale of the sublimation...
April 16, 2024: Chemistry: a European Journal
#3
JOURNAL ARTICLE
Erica McArdle, Sameer Shetty, Dominic Coutinho, Hassan H Ramadan, Chadi A Makary
BACKGROUND: Studies in adult chronic rhinosinusitis (CRS) showed poor correlation between patient reported outcome measures (PROMs) and objective findings. Our goal is to study the correlation between the sinus and nasal quality of life (SN-5) and the 22-items sinonasal outcome test (SNOT-22) surveys with endoscopy findings in children with chronic adenoiditis (CA) and CRS. METHODS: Cross-sectional study of all pediatric patients (age 2-18) presenting for CA or CRS was performed...
April 2024: International Journal of Pediatric Otorhinolaryngology
#4
JOURNAL ARTICLE
Seán Hennessey, Roberto González-Gómez, Kathryn McCarthy, Christopher S Burke, Camille Le Houérou, Nirod Kumar Sarangi, Patrick McArdle, Tia E Keyes, Fabio Cucinotta, Pau Farràs
Recentstudies toward finding more efficient ruthenium metalloligands for photocatalysis applications have shown that the derivatives of the linear [Ru(dqp)2 ]2+ (dqp: 2,6-di(quinolin-8-yl)-pyridine) complexes hold significant promise due to their extended emission lifetime in the μs time scale while retaining comparable redox potential, extinction coefficients, and absorption profile in the visible region to [Ru(bpy)3 ]2+ (bpy: 2,2'-bipyridine) and [Ru(tpy)2 ]2+ (tpy: 2,2':6',2″-terpyridine) complexes...
March 26, 2024: ACS Omega
#5
JOURNAL ARTICLE
Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch-Ernst, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Margarita Aguilera-Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Rosangela Marchelli, Monika Neuhäuser-Berthold, Morten Poulsen, Miguel Prieto Maradona, Josef Rudolf Schlatter, Alexandros Siskos, Henk van Loveren, Wolfgang Gelbmann, Helle Katrine Knutsen
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of magnesium l-threonate as a novel food (NF) pursuant to Regulation (EU) 2015/2283 and to address the bioavailability of magnesium from this source in the context of Directive 2002/46/EC. The NF, produced by chemical synthesis, is intended to be used as new source for magnesium in food supplements at a maximum intake level of 3000 mg per day by adults, except for pregnant and lactating women...
March 2024: EFSA journal
#6
JOURNAL ARTICLE
Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch-Ernst, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Margarita Aguilera-Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Miguel Prieto Maradona, Monika Neuhäuser-Berthold, Morten Poulsen, Josef Rudolf Schlatter, Alexandros Siskos, Henk van Loveren, Maria Glymenaki, Eirini Kouloura, Helle Katrine Knutsen
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on ashitaba sap as a novel food (NF) pursuant to Regulation (EU) 2015/2283. Ashitaba sap is collected from harvested stems of Angelica keiskei plants. The principal constituents of the sap with regard to the safety assessment are chalcones (1%-2.25%) and furanocoumarins (< 0.01%). The applicant proposed to use the NF in food supplements at a maximum dose of 780 mg per day...
March 2024: EFSA journal
#7
JOURNAL ARTICLE
Nicolas Farina, Ríona McArdle, Ruth G Lowry, Sube Banerjee
Previous research has explored the physical activity habits of people with dementia and their family carers separately, with little consideration of how physical habits are associated within dyads. In this observational study, we sought to explore the relationship between people with dementia and their carers' physical activity, at a group level and at a dyadic level. Twenty-six participant dyads (persons with dementia and their carer spouses) were asked to wear an accelerometer for 30 days continuously...
March 4, 2024: Journal of Aging and Physical Activity
#8
REVIEW
Isabelle Engels, Monika Weingartz, Cornelia Kornblum, Lorenz Grigull
No abstract text is available yet for this article.
February 2024: MMW Fortschritte der Medizin
#9
JOURNAL ARTICLE
Giulia Andrighetto, Aron Szekely, Andrea Guido, Michele Gelfand, Jered Abernathy, Gizem Arikan, Zeynep Aycan, Shweta Bankar, Davide Barrera, Dana Basnight-Brown, Anabel Belaus, Elizaveta Berezina, Sheyla Blumen, Paweł Boski, Huyen Thi Thu Bui, Juan Camilo Cárdenas, Đorđe Čekrlija, Mícheál de Barra, Piyanjali de Zoysa, Angela Dorrough, Jan B Engelmann, Hyun Euh, Susann Fiedler, Olivia Foster-Gimbel, Gonçalo Freitas, Marta Fülöp, Ragna B Gardarsdottir, Colin Mathew Hugues D Gill, Andreas Glöckner, Sylvie Graf, Ani Grigoryan, Katarzyna Growiec, Hirofumi Hashimoto, Tim Hopthrow, Martina Hřebíčková, Hirotaka Imada, Yoshio Kamijo, Hansika Kapoor, Yoshihisa Kashima, Narine Khachatryan, Natalia Kharchenko, Diana León, Lisa M Leslie, Yang Li, Kadi Liik, Marco Tullio Liuzza, Angela T Maitner, Pavan Mamidi, Michele McArdle, Imed Medhioub, Maria Luisa Mendes Teixeira, Sari Mentser, Francisco Morales, Jayanth Narayanan, Kohei Nitta, Ravit Nussinson, Nneoma G Onyedire, Ike E Onyishi, Evgeny Osin, Seniha Özden, Penny Panagiotopoulou, Oleksandr Pereverziev, Lorena R Perez-Floriano, Anna-Maija Pirttilä-Backman, Marianna Pogosyan, Jana Raver, Cecilia Reyna, Ricardo Borges Rodrigues, Sara Romanò, Pedro P Romero, Inari Sakki, Angel Sánchez, Sara Sherbaji, Brent Simpson, Lorenzo Spadoni, Eftychia Stamkou, Giovanni A Travaglino, Paul A M Van Lange, Fiona Fira Winata, Rizqy Amelia Zein, Qing-Peng Zhang, Kimmo Eriksson
The emergence of COVID-19 dramatically changed social behavior across societies and contexts. Here we study whether social norms also changed. Specifically, we study this question for cultural tightness (the degree to which societies generally have strong norms), specific social norms (e.g. stealing, hand washing), and norms about enforcement, using survey data from 30,431 respondents in 43 countries recorded before and in the early stages following the emergence of COVID-19. Using variation in disease intensity, we shed light on the mechanisms predicting changes in social norm measures...
February 16, 2024: Nature Communications
#10
JOURNAL ARTICLE
Indumathi Patta, Maryam Zand, Lindsay Lee, Shreya Mishra, Alexandra Bortnick, Hanbin Lu, Arpita Prusty, Sara McArdle, Zbigniew Mikulski, Huan-You Wang, Christine S Cheng, Kathleen M Fisch, Ming Hu, Cornelis Murre
It is well established that neutrophils adopt malleable polymorphonuclear shapes to migrate through narrow interstitial tissue spaces1-3 . However, how polymorphonuclear structures are assembled remains unknown4 . Here we show that in neutrophil progenitors, halting loop extrusion-a motor-powered process that generates DNA loops by pulling in chromatin5 -leads to the assembly of polymorphonuclear genomes. Specifically, we found that in mononuclear neutrophil progenitors, acute depletion of the loop-extrusion loading factor nipped-B-like protein (NIPBL) induced the assembly of horseshoe, banded, ringed and hypersegmented nuclear structures and led to a reduction in nuclear volume, mirroring what is observed during the differentiation of neutrophils...
February 14, 2024: Nature
#11
JOURNAL ARTICLE
Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch-Ernst, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Margarita Aguilera-Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Rosangela Marchelli, Monika Neuhäuser-Berthold, Morten Poulsen, Miguel Prieto Maradona, Josef Rudolf Schlatter, Alexandros Siskos, Henk van Loveren, Océane Albert, Helle Katrine Knutsen
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the extension of use of isomalto-oligosaccharide (IMO) as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF consists of glucose oligomers with degrees of polymerisation of 3-9, along with various amounts of mono- and disaccharides. The NF comes in both syrup and powder form. The applicant intends to extend the current uses of the NF as an ingredient in several foods, and use the NF in food supplements aimed at the general population older than 10 years of age...
February 2024: EFSA journal
#12
JOURNAL ARTICLE
Pedro L Valenzuela, Alfredo Santalla, Lidia B Alejo, Asunción Bustos, Laureano M Ozcoidi, Laura Castellote-Bellés, Roser Ferrer-Costa, Mónica Villarreal-Salazar, María Morán, David Barranco-Gil, Tomàs Pinós, Alejandro Lucia
BACKGROUND & AIMS: Ketone supplementation is gaining popularity. Yet, its effects on exercise performance when muscle glycogen cannot be used remain to be determined. McArdle disease can provide insight into this question, as these patients are unable to obtain energy from muscle glycogen, presenting a severely impaired physical capacity. We therefore aimed to assess the effects of acute ketone supplementation in the absence of muscle glycogen utilization (McArdle disease). METHODS: In a randomized cross-over design, patients with an inherited block in muscle glycogen breakdown (i...
March 2024: Clinical Nutrition
#13
JOURNAL ARTICLE
Elin H Thorarinsdottir, Allan I Pack, Thorarinn Gislason, Samuel T Kuna, Thomas Penzel, Qing Yun Li, Peter A Cistulli, Ulysses J Magalang, Nigel McArdle, Bhajan Singh, Christer Janson, Thor Aspelund, Magdy Younes, Philip de Chazal, Sergio Tufik, Brendan T Keenan
STUDY OBJECTIVES: Excessive daytime sleepiness (EDS) is a major symptom of obstructive sleep apnea (OSA). Traditional polysomnographic (PSG) measures only partially explain EDS in OSA. This study analyzed traditional and novel PSG characteristics of two different measures of EDS among OSA patients. METHODS: Sleepiness was assessed using the Epworth Sleepiness Scale (>10 points defined as "risk of dozing") and a measure of general sleepiness (feeling sleepy ≥3 times/week defined as "feeling sleepy")...
February 5, 2024: Sleep
#14
Mariana de Brito Gregório, João Pedro Pires Fonseca, Maria Madalena Oliveira Adrião, Elisabete Oliveira Valente Cavaco
Chronic postoperative pain (CPOP) is a potentially devastating consequence of a surgical procedure. It leads to increased medical costs, painful, and stress experience to the patients. After a surgical decompression performed in a patient with a non-traumatic compartment syndrome, a muscle biopsy confirmed McArdle disease, and after surgery, severe pain of neuropathic characteristics developed in the arm decompressed. Advanced techniques up to neuromedullary stimulation failed to improve the clinical status, after which repeated treatment with capsaicin patch ameliorated the patient's condition...
2024: Saudi Journal of Anaesthesia
#15
JOURNAL ARTICLE
Rúbens Prince Dos Santos Alves, Julia Timis, Robyn Miller, Kristen Valentine, Paolla Beatriz Almeida Pinto, Andrew Gonzalez, Jose Angel Regla-Nava, Erin Maule, Michael N Nguyen, Norazizah Shafee, Sara Landeras-Bueno, Eduardo Olmedillas, Brett Laffey, Katarzyna Dobaczewska, Zbigniew Mikulski, Sara McArdle, Sarah R Leist, Kenneth Kim, Ralph S Baric, Erica Ollmann Saphire, Annie Elong Ngono, Sujan Shresta
SARS-CoV-2-reactive T cells are detected in some healthy unexposed individuals. Human studies indicate these T cells could be elicited by the common cold coronavirus OC43. To directly test this assumption and define the role of OC43-elicited T cells that are cross-reactive with SARS-CoV-2, we develop a model of sequential infections with OC43 followed by SARS-CoV-2 in HLA-B*0702 and HLA-DRB1*0101 Ifnar1-/- transgenic mice. We find that OC43 infection can elicit polyfunctional CD8+ and CD4+ effector T cells that cross-react with SARS-CoV-2 peptides...
January 26, 2024: Nature Communications
#16
JOURNAL ARTICLE
Dominique Turck, Harry J McArdle, Androniki Naska, Monika Neuhäuser-Berthold, Giovanni Passeri, Ionut Craciun, Ruth Roldán-Torres, Silvia Valtueña Martínez
EFSA was asked by the European Commission to provide scientific assistance with respect to the EFSA adopted scientific opinion on 'Safety of calcidiol monohydrate produced by chemical synthesis as a novel food pursuant to Regulation (EU) 2015/2283', including its bioavailability as a metabolite of vitamin D3 when added for nutritional purposes to food supplements. On 5 July 2023, EFSA adopted the 'Scientific opinion on the tolerable upper intake level for vitamin D, including the derivation of a conversion factor for calcidiol monohydrate'...
January 2024: EFSA journal
#17
JOURNAL ARTICLE
Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch-Ernst, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Margarita Aguilera-Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Rosangela Marchelli, Monika Neuhäuser-Berthold, Carmen Peláez, Morten Poulsen, Miguel Prieto Maradona, Josef Rudolf Schlatter, Alexandros Siskos, Henk van Loveren, Maura Magani, Alejandra Muñoz, Annamaria Rossi, Helle Katrine Knutsen
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on HelixComplex Snail Mucus (HSM) as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF consists of snail mucus collected from Helix aspersa maxima and is proposed to be used by adults as a food supplement. The data provided by the applicant about the composition and stability of the NF together with the report of the subchronic toxicity study were overall considered unsatisfactory...
January 2024: EFSA journal
#18
JOURNAL ARTICLE
Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch-Ernst, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Margarita Aguilera-Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Rosangela Marchelli, Monika Neuhäuser-Berthold, Morten Poulsen, Miguel Prieto Maradona, Josef Rudolf Schlatter, Alexandros Siskos, Henk van Loveren, Lucien Ferreira da Costa, Océane Albert, Helle Katrine Knutsen
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on isomaltulose syrup (dried) as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF consists of a mixture of mono- and disaccharides in powder form, mainly composed of isomaltulose (≥ 75%) and trehalulose (< 13%). The applicant intends to use the NF as a replacement for sucrose already on the market. The information provided on the manufacturing process, composition and specifications of the NF is sufficient and does not raise safety concerns...
January 2024: EFSA journal
#19
João R Oliveira, João P Pereira, Mariana F Branco, Luísa C Leite, Ana I Patrício
McArdle's disease is a rare autosomal recessive disorder that affects glycogen storage. It typically manifests in adolescence or early adulthood with presenting symptoms, such as fatigue, myalgia, exercise intolerance, and cramps, which can be easily overlooked. This case report seeks to offer a comprehensive overview of the perspective of a patient living with McArdle's disease, emphasizing the importance of treatment encouragement. The report documents the case of a 25-year-old male presenting with myalgia and fatigue exacerbated by strenuous exercise, illustrating the diagnostic challenges associated with McArdle's disease, primarily attributable to clinician unawareness...
December 2023: Curēus
#20
Erica Saphire, Zhe Li Salie, Zunlong Ke, Peter Halfmann, Lisa Evans DeWald, Sara McArdle, Ariadna Grinyo, Edgar Davidson, Sharon Schendel, Chitra Hariharan, Michael Norris, Xiaoying Yu, Chakravarthy Chennareddy, Xiaoli Xiong, Megan Heinrich, Michael Holbrook, Benjamin Doranz, Ian Crozier, Kathryn Hastie, Yoshihiro Kawaoka, Luis Branco, Jens Kuhn, John Briggs, Gabriella Worwa, Carl Davis, Rafi Ahmed
Monoclonal antibodies (mAbs) against Ebola virus (EBOV) glycoprotein (GP 1,2 ) are the standard of care for Ebola virus disease (EVD). Anti-GP 1,2 mAbs targeting the stalk and membrane proximal external region (MPER) potently neutralize EBOV in vitro . However, their neutralization mechanism is poorly understood because they target a GP 1,2 epitope that has evaded structural characterization. Moreover, their in vivo efficacy has only been evaluated in the mouse model of EVD. Using x-ray crystallography and cryo-electron tomography of 3A6 complexed with its stalk- GP 1,2 MPER epitope we reveal a novel mechanism in which 3A6 elevates the stalk or stabilizes a conformation of GP 1,2 that is lifted from the virion membrane...
December 22, 2023: Research Square
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