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https://www.readbyqxmd.com/read/28800603/genetic-variants-specific-to-aging-related-verbal-memory-insights-from-gwass-in-a-population-based-cohort
#1
Thalida E Arpawong, Neil Pendleton, Krisztina Mekli, John J McArdle, Margaret Gatz, Chris Armoskus, James A Knowles, Carol A Prescott
Verbal memory is typically studied using immediate recall (IR) and delayed recall (DR) scores, although DR is dependent on IR capability. Separating these components may be useful for deciphering the genetic variation in age-related memory abilities. This study was conducted to (a) construct individual trajectories in IR and independent aspects of delayed recall, or residualized-DR (rDR), across older adulthood; and (b) identify genetic markers that contribute to four estimated phenotypes: IR and rDR levels and changes after age 60...
2017: PloS One
https://www.readbyqxmd.com/read/28796012/successful-electroconvulsive-therapy-for-a-patient-with-mcardle-disease
#2
Francois-Xavier Robert, Pauline Modica, Guillaume Lagrange, David Delahaye, François Prima, Philippe Vilcoq, Jacques Albanese, Christophe Lançon, Raphaëlle Richieri
No abstract text is available yet for this article.
August 9, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28792061/role-of-nerve-muscle-interactions-and-ros-in-regulation-of-muscle-proteostasis-with-aging
#3
Aphrodite Vasilaki, Arlan Richardson, Holly Van Remmen, Susan V Brooks, Lisa Larkin, Anne McArdle, Malcolm J Jackson
Skeletal muscle aging is characterised by atrophy, a deficit in specific force generation, increased susceptibility to injury, and incomplete recovery after severe damage. The hypothesis that increased generation of Reactive Oxygen Species (ROS) in vivo plays a key role in the aging process has been extensively studied, but remains controversial. Skeletal muscle generates ROS at rest and during exercise. ROS can cause oxidative damage particularly to proteins. Indeed, products of oxidative damage accumulate in skeletal muscle during aging and the ability of muscle cells to respond to increased ROS becomes defective...
August 9, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28781767/senescence-in-the-aging-process
#4
REVIEW
Richard Ga Faragher, Anne McArdle, Alison Willows, Elizabeth L Ostler
The accumulation of 'senescent' cells has long been proposed to act as an ageing mechanism. These cells display a radically altered transcriptome and degenerative phenotype compared with their growing counterparts. Tremendous progress has been made in recent years both in understanding the molecular mechanisms controlling entry into the senescent state and in the direct demonstration that senescent cells act as causal agents of mammalian ageing. The challenges now are to gain a better understanding of how the senescent cell phenotype varies between different individuals and tissues, discover how senescence predisposes to organismal frailty, and develop mechanisms by which the deleterious effects of senescent cells can be ameliorated...
2017: F1000Research
https://www.readbyqxmd.com/read/28760599/gonadotropin-releasing-hormone-signaling-an-information-theoretic-approach
#5
REVIEW
Margaritis Voliotis, Kathryn L Garner, Hussah Alobaid, Krasimira Tsaneva-Atanasova, Craig A McArdle
Gonadotropin-releasing hormone (GnRH) is a peptide hormone that mediates central control of reproduction, acting via G-protein coupled receptors that are primarily Gq coupled and mediate GnRH effects on the synthesis and secretion of luteinizing hormone and follicle-stimulating hormone. A great deal is known about the GnRH receptor signaling network but GnRH is secreted in short pulses and much less is known about how gonadotropes decode this pulsatile signal. Similarly, single cell measures reveal considerable cell-cell heterogeneity in responses to GnRH but the impact of this variability on signaling is largely unknown...
July 29, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28752234/implementing-a-tobacco-free-hospital-campus-in-ireland-lessons-learned
#6
D McArdle, Z Kabir
BACKGROUND: The Irish Health Service Executive (HSE) had set a target that all HSE facilities should implement the HSE Tobacco Free Campus (TFC) policy by 2015. AIM: The aims of this study are to examine hospital staff awareness and to assess the progress of selected HSE health care facilities towards a TFC policy. METHODS: Three health care facilities that were conveniently located were self-selected in County Cork, namely, an acute hospital, a mental health service and an older person's facility...
July 27, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28748366/clinical-features-of-psoriatic-arthritis-a-comprehensive-review-of-unmet-clinical-needs
#7
REVIEW
Angela McArdle, Stephen Pennington, Oliver FitzGerald
Psoriatic arthritis (PsA) is a form of inflammatory arthritis (IA) affecting approximately 0.25% of the population. It is a heterogeneous disorder associated with joint damage, disability, disfiguring skin disease and in severe cases, premature mortality. Inherently irreversible and frequently progressive, the process of joint damage begins at, or before, the clinical onset of disease. Early recognition and intervention is thus crucial to patient outcome. At disease onset, however, PsA often resembles other forms of arthritis-especially rheumatoid arthritis (RA)...
July 27, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28743190/effect-of-obstructive-sleep-apnea-treatment-on-renal-function-in-patients-with-cardiovascular-disease
#8
Kelly A Loffler, Emma Heeley, Ruth Freed, Craig S Anderson, Ben Brockway, Alastair Corbett, Catharina L Chang, James A Douglas, Katherine Ferrier, Neil Graham, Garun S Hamilton, Michael Hlavac, Nigel McArdle, John McLachlan, Sutapa Mukherjee, Matthew T Naughton, Francis Thien, Alan Young, Ronald R Grunstein, Lyle J Palmer, Richard J Woodman, Patrick J Hanly, R Doug McEvoy
RATIONALE: Obstructive sleep apnea (OSA) is associated with impaired renal function, but uncertainty exists over whether OSA treatment can influence renal outcomes. OBJECTIVES: To determine the effects of continuous positive airway pressure (CPAP) on renal function in subjects with co-existing OSA and cardiovascular disease. METHODS: This was a substudy of the international Sleep Apnea and cardioVascular Endpoints (SAVE) trial that randomized 2717 patients with moderate-severe OSA and established coronary or cerebrovascular disease to receive CPAP plus usual care, or usual care alone...
July 25, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28739532/denervated-muscle-fibers-induce-mitochondrial-peroxide-generation-in-neighboring-innervated-fibers-role-in-muscle-aging
#9
Natalie Pollock, Caroline A Staunton, Aphrodite Vasilaki, Anne McArdle, Malcolm J Jackson
Disruption of neuromuscular junctions and denervation of some muscle fibers occurs in ageing skeletal muscle and contribute to loss of muscle mass and function. Aging is associated with mitochondrial dysfunction and loss of redox homeostasis potentially occurs through increased mitochondrial generation of reactive oxygen species (ROS). No specific link between increased mitochondrial ROS generation and denervation has been defined in muscle ageing. To address this, we have examined the effect of experimental denervation of all fibers, or only a proportion of the fibers, in the mouse tibialis anterior (TA) muscle on muscle mitochondrial peroxide generation...
July 21, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28716914/metabolic-profiles-of-exercise-in-patients-with-mcardle-disease-or-mitochondrial-myopathy
#10
Nigel F Delaney, Rohit Sharma, Laura Tadvalkar, Clary B Clish, Ronald G Haller, Vamsi K Mootha
McArdle disease and mitochondrial myopathy impair muscle oxidative phosphorylation (OXPHOS) by distinct mechanisms: the former by restricting oxidative substrate availability caused by blocked glycogen breakdown, the latter because of intrinsic respiratory chain defects. We applied metabolic profiling to systematically interrogate these disorders at rest, when muscle symptoms are typically minimal, and with exercise, when symptoms of premature fatigue and potential muscle injury are unmasked. At rest, patients with mitochondrial disease exhibit elevated lactate and reduced uridine; in McArdle disease purine nucleotide metabolites, including xanthine, hypoxanthine, and inosine are elevated...
August 1, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28705462/effectiveness-of-a-group-b-outer-membrane-vesicle-meningococcal-vaccine-against-gonorrhoea-in-new-zealand-a-retrospective-case-control-study
#11
Helen Petousis-Harris, Janine Paynter, Jane Morgan, Peter Saxton, Barbara McArdle, Felicity Goodyear-Smith, Steven Black
BACKGROUND: Gonorrhoea is a major global public health problem that is exacerbated by drug resistance. Effective vaccine development has been unsuccessful, but surveillance data suggest that outer membrane vesicle meningococcal group B vaccines affect the incidence of gonorrhoea. We assessed vaccine effectiveness of the outer membrane vesicle meningococcal B vaccine (MeNZB) against gonorrhoea in young adults aged 15-30 years in New Zealand. METHODS: We did a retrospective case-control study of patients at sexual health clinics aged 15-30 years who were born between Jan 1, 1984, and Dec 31, 1998, eligible to receive MeNZB, and diagnosed with gonorrhoea or chlamydia, or both...
July 7, 2017: Lancet
https://www.readbyqxmd.com/read/28703894/comparison-of-resting-energy-equations-and-total-energy-expenditure-in-haemodialysis-patients-and-body-composition-measured-by-multi-frequency-bioimpedance
#12
Ben Oliveira, Sivakumar Sridharan, Ken Farrington, Andrew Davenport
BACKGROUND: Waste products of metabolism are retained in haemodialysis (HD) patients. Cellular metabolism generates energy, and patients with greater energy expenditure may therefore require more dialysis. To determine the amount of dialysis required, equations estimating resting and total energy expenditure (REE,TEE) are required. METHODS: We compared estimates of REE in HD patients using established equations with a novel equation recently validated in HD patients (HD equation)...
July 13, 2017: Nephrology
https://www.readbyqxmd.com/read/28699441/maintaining-standards-in-difficult-times
#13
Jennifer Trueland
'We're in a good place in nursing - we've got high-calibre students emerging, and there's a huge opportunity for nurses to lead change', says Northern Ireland's chief nurse Charlotte McArdle.
July 12, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28698308/the-role-of-attenuated-redox-and-heat-shock-protein-responses-in-the-age-related-decline-in-skeletal-muscle-mass-and-function
#14
REVIEW
Anne McArdle, Malcolm J Jackson
The loss of muscle mass and weakness that accompanies ageing is a major contributor to physical frailty and loss of independence in older people. A failure of muscle to adapt to physiological stresses such as exercise is seen with ageing and disruption of redox regulated processes and stress responses are recognized to play important roles in theses deficits. The role of redox regulation in control of specific stress responses, including the generation of heat shock proteins (HSPs) by muscle appears to be particularly important and affected by ageing...
July 15, 2017: Essays in Biochemistry
https://www.readbyqxmd.com/read/28670532/are-predictive-equations-for-estimating-resting-energy-expenditure-accurate-in-asian-indian-male-weightlifters
#15
Mini Joseph, Riddhi Das Gupta, L Prema, Mercy Inbakumari, Nihal Thomas
BACKGROUND: The accuracy of existing predictive equations to determine the resting energy expenditure (REE) of professional weightlifters remains scarcely studied. Our study aimed at assessing the REE of male Asian Indian weightlifters with indirect calorimetry and to compare the measured REE (mREE) with published equations. A new equation using potential anthropometric variables to predict REE was also evaluated. MATERIALS AND METHODS: REE was measured on 30 male professional weightlifters aged between 17 and 28 years using indirect calorimetry and compared with the eight formulas predicted by Harris-Benedicts, Mifflin-St...
July 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28660497/mcardle-disease-a-pediatric-disorder-presenting-in-an-adult-with-acute-kidney-injury
#16
Xixi Zhao, Angela Li, Madhu Soni, Michael J Muriello, Carolyn H Jones, William L Whittier
Rhabdomyolysis is characterized by the acute breakdown of skeletal muscle, resulting in the release of muscle cell contents, subsequent myoglobinuria, and in severe cases, acute renal failure. A number of etiologies have been identified in acute rhabdomyolysis, in which drugs and trauma account for the majority of cases. One etiological category that is commonly overlooked in the adult population is an underlying genetic defect. This may be challenging to diagnose due to its rarity in the adult demographic and the marked heterogeneity, often requiring a high level of clinical suspicion before investigation is pursued...
June 28, 2017: CEN Case Reports
https://www.readbyqxmd.com/read/28649515/higher-oxidative-stress-in-skeletal-muscle-of-mcardle-disease-patients
#17
Jan J Kaczor, Holly A Robertshaw, Mark A Tarnopolsky
McArdle disease (MCD) is an autosomal recessive condition resulting from skeletal muscle glycogen phosphorylase deficiency. The resultant block in glycogenolysis leads to an increased flux through the xanthine oxidase pathway (myogenic hyperuricemia) and could lead to an increase in oxidative stress. We examined markers of oxidative stress (8-isoprostane and protein carbonyls), NAD(P)H-oxidase, xanthine oxidase and antioxidant enzyme (superoxide dismutase, catalase and glutathione peroxidase) activity in skeletal muscle of MCD patients (N = 12) and controls (N = 12)...
September 2017: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/28646704/location-and-characterization-of-lignin-in-tracheid-cell-walls-of-radiata-pine-pinus-radiata-d-don-compression-woods
#18
Miao Zhang, Catherine Lapierre, Noor Liyana Nouxman, Michel K Nieuwoudt, Bronwen G Smith, Ramesh R Chavan, Brian H McArdle, Philip J Harris
Tilted stems of softwoods form compression wood (CW) and opposite wood (OW) on their lower and upper sides, respectively. More is known about the most severe form of CW, severe CW (SCW), but mild CWs (MCWs) also occur widely. Two grades of MCWs, MCW1 and MCW2, as well as SCW and OW were identified in the stems of radiata pine (Pinus radiata) that had been slightly tilted. The four wood types were identified by the distribution of lignin in the tracheid walls determined by fluorescence microscopy. A solution of the fluorescent dye acridine orange (AO) (0...
June 15, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28645175/perturbation-to-cholesterol-at-the-neuromuscular-junction-confers-botulinum-neurotoxin-a-sensitivity-to-neonatal-mice
#19
Baskaran Thyagarajan, Joseph G Potian, Joseph J McArdle, Padmamalini Baskaran
Botulinum neurotoxin A (BoNT/A) cleaves SNAP25 at the motor nerve terminals (MNT) and inhibits stimulus evoked acetylcholine release (SEAR). This causes skeletal muscle paralysis. However, younger neonatal mice (<P7; less than 7 days old) are resistant to the neuroparalytic effects of BoNT/A. That is, in vivo injection of BoNT/A at the innervations of Extensor digitorum longus (EDL) muscle in the hindlimbs inhibited the toe spread reflex within 24 hours following BoNT/A injection in adult mouse and in older (> P7) neonatal mice younger than 7 days-age remained unaffected by BoNT/A injection...
June 22, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28633812/sonochemical-synthesis-of-a-new-cobalt-ii-complex-crystal-structure-thermal-behavior-hirshfeld-surface-analysis-and-its-usage-as-precursor-for-preparation-of-coo-co3o4-nanoparticles
#20
Morteza Montazerozohori, Ardavan Masoudiasl, Sara Farokhiyani, Shiva Joohari, Patrick McArdle
A bidentate Schiff base ligand and its nano-structured cobalt(II) complex were synthesized under ultrasound irradiation and then their structures were identified by physical and spectral techniques SEM and XRD techniques were used to confirm the nanostructure character of the complex. Single crystal X-ray diffraction analysis showed that the complex crystallizes in the triclinic system with space group of P1¯ and two crystallographically independent molecules participate in its asymmetric unit. In the structure of complex, cobalt center is four-coordinated by two iminic nitrogens of bidentate Schiff base ligand and two bromide anions in a distorted tetrahedral geometry...
September 2017: Ultrasonics Sonochemistry
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