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https://www.readbyqxmd.com/read/29241083/a-review-of-the-value-of-human-epidermal-growth-factor-receptor-2-her2-targeted-therapies-in-breast-cancer
#1
REVIEW
N A Nixon, M B Hannouf, S Verma
The cost of cancer drugs continues to escalate with the rapid development and approval of novel therapies, especially over the course of the last decade. In human epidermal growth factor receptor 2 (HER2)-positive breast cancer, the survival benefits gained by new treatments have been undeniably substantial. It is important to assess the financial value of these therapies for decision making at both the societal and individual level. This information is key for managing resources in resource-limited health care systems, while at the same time supporting patient decision-making and conversations between patient and physicians on cost versus benefit...
December 10, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29240798/the-cost-of-comorbidities-in-treatment-for-hiv-aids-in-california
#2
David S Zingmond, Kodi B Arfer, Jennifer L Gildner, Arleen A Leibowitz
BACKGROUND: Antiretroviral therapy has increased longevity for people living with HIV (PLWH). As a result, PLWH increasingly experience the common diseases of aging and the resources needed to manage these comorbidities are increasing. This paper characterizes the number and types of comorbidities diagnosed among PLWH covered by Medicare and examines how non-HIV comorbidities relate to outpatient, inpatient, and pharmaceutical expenditures. METHODS: The study examined Medicare expenditures for 9767 HIV-positive Californians enrolled in Medicare in 2010 (7208 persons dually covered by Medicare and Medicaid and 2559 with Medicare only)...
2017: PloS One
https://www.readbyqxmd.com/read/29240744/an-osteoarthritis-model-of-care-should-be-a-national-priority-for-new-zealand
#3
Jennifer Baldwin, Andrew Briggs, Warwick Bagg, Peter Larmer
Osteoarthritis is highly prevalent, disabling and costly to the person and the community. The burden of this chronic condition is predicted to increase dramatically over the coming decades. Healthcare spending on osteoarthritis is unsustainable and action is needed to improve care delivery. At present, there is an over-emphasis on surgical and pharmacological interventions, despite evidence supporting conservative treatments such as exercise, weight loss and education. While clinical guidelines provide recommendations regarding best practice (ie, what to do), they fail to address how to operationalise these recommendations into clinical practice...
December 15, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29240632/methods-for-sexually-transmitted-disease-prevention-programs-to-estimate-the-health-and-medical-cost-impact-of-changes-in-their-budget
#4
Harrell W Chesson, Jennifer A Ludovic, Andrés A Berruti, Thomas L Gift
BACKGROUND: The purpose of this article was to describe methods that sexually transmitted disease (STD) programs can use to estimate the potential effects of changes in their budgets in terms of disease burden and direct medical costs. METHODS: We proposed 2 distinct approaches to estimate the potential effect of changes in funding on subsequent STD burden, one based on an analysis of state-level STD prevention funding and gonorrhea case rates and one based on analyses of the effect of Disease Intervention Specialist (DIS) activities on gonorrhea case rates...
January 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29239999/care-management-to-reduce-disparities-and-control-hypertension-in-primary-care-a-cost-effectiveness-analysis
#5
Jonathan C Hong, William V Padula, Ilene L Hollin, Tanvir Hussain, Katherine B Dietz, Jennifer P Halbert, Jill A Marsteller, Lisa A Cooper
BACKGROUND: Project ReD CHiP (reducing disparities and controlling hypertension in primary care) care management was a clinic-based intervention that aimed to improve blood pressure control through improved care coordination and provide self-management support to patients from racially and socioeconomically. OBJECTIVE: To evaluate the cost-effectiveness of ReD CHiP care management versus standard care to treat hypertension in diverse communities. RESEARCH DESIGN: Microsimulation model from a health care sector perspective over 15 years...
December 12, 2017: Medical Care
https://www.readbyqxmd.com/read/29239580/promotion-of-mental-health-in-the-core-of-public-health-work
#6
Kristian Wahlbeck, Marjo Hannukkala, Johannes Parkkonen, Jukka Valkonen, Tytti Solantaus
Positive trends achieved in health in Finland are not equally reflected mental health, hence mental health promotion deserves a central position. Mental health promotion refers to strengthening of psychological resources, and has been linked to increased well-being and life satisfaction. Health care has an important role in supporting a solid foundation of mental health and in preventing intergenerational transmission of problems. Mental health promotion requires strong involvement of non-health sectors. There are means for strengthening mental health skills also on the individual level...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29239578/national-vaccination-program-a-success-story-of-public-health-and-economy
#7
Heini Salo, Terhi Kilpi
The savings in treatment costs generated by disease cases prevented by the national vaccination program exceed the costs of the vaccination program by at least 60 million euros. In addition, other costs due to contracting the illness are avoided. Vaccinations serve the purpose of both increasing well-being and releasing resources for other uses. Financial support of vaccinations through the health insurance system would be costly and targetted to those with the ability to pay. Public funds should be directed to the development of a vaccination program...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29239575/what-s-at-stake-states-progress-on-health-coverage-and-access-to-care-2013%C3%A2-2016
#8
Susan L Hayes, Sarah R Collins, David C Radley, Douglas McCarthy
Issue: Given uncertainty about the future of the Affordable Care Act, it is useful to examine the progress in coverage and access made under the law. Goal: Compare state trends in access to affordable health care between 2013 and 2016. Methods: Analysis of recent data from the U.S. Census Bureau and the Behavioral Risk Factor Surveillance System. Findings and Conclusions: Between 2013 and 2016, the uninsured rate for adults ages 19 to 64 declined in all states and the District of Columbia, and fell by at least 5 percentage points in 47 states...
December 1, 2017: Issue Brief of the Commonwealth Fund
https://www.readbyqxmd.com/read/29239234/adoption-of-in-vitro-systems-and-zebrafish-embryos-as-alternative-models-for-reducing-rodent-use-in-assessments-of-immunological-and-oxidative-stress-responses-to-nanomaterials
#9
Helinor J Johnston, Rachel Verdon, Suzanne Gillies, David M Brown, Teresa F Fernandes, Theodore B Henry, Adriano G Rossi, Lang Tran, Carl Tucker, Charles R Tyler, Vicki Stone
Assessing the safety of engineered nanomaterials (NMs) is paramount to the responsible and sustainable development of nanotechnology, which provides huge societal benefits. Currently, there is no evidence that engineered NMs cause detrimental health effects in humans. However, investigation of NM toxicity using in vivo, in vitro, in chemico, and in silico models has demonstrated that some NMs stimulate oxidative stress and inflammation, which may lead to adverse health effects. Accordingly, investigation of these responses currently dominates NM safety assessments...
December 14, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/29239194/-immunotherapy-of-renal-cell-carcinoma
#10
A Poprach, R Lakomý, T Büchler
Treatment of renal cell carcinoma is still palliative. Targeted therapy increases response rates and prolongs overall survival and progression-free survival compared with cytokines and chemotherapy. Checkpoint inhibitors constitute the up-date of therapeutic approaches, and anti-PD-1 antibody, one checkpoint inhibitor, is now well established as a second and/or third palliative treatment for patients with renal cell carcinoma. In this study, we present the latest data from current studies on cytokines, cancer vaccines, ipilimumab, and nivolumab...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29238679/novel-program-of-using-village-health-workers-in-early-detection-and-awareness-of-head-and-neck-cancers-audit-of-a-community-screening-program
#11
Girish S Mishra, Sushen H Bhatt
Head and neck cancers together (oral cavity, pharynx and larynx) are sixth commonest worldwide and are the commonest cancers in developing countries. The Cancer Project was started in Kheda/Anand, Gujarat, a harvest land of tobacco. The objective of this programme was to indoctrinate the most vulnerable and the least tended upon; the basics of head and neck cancers via the medium of their own kins. Voluntary village health workers were educated and trained to pick up the early signs of head and neck cancers...
December 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29238634/asa-classification-as-a-risk-stratification-tool-in-adult-spinal-deformity-surgery-a-study-of-5805-patients
#12
Sulaiman Somani, John Di Capua, Jun S Kim, Kevin Phan, Nathan J Lee, Parth Kothari, Joung-Heon Kim, James Dowdell, Samuel K Cho
Study Design: Retrospective analysis of prospectively collected data. Objectives: Adult spinal deformity (ASD) surgery is a highly complex procedure that has high complication rates. Risk stratification tools can improve patient management and may lower complication rates and associated costs. The goal of this study was to identify the independent association between American Society of Anesthesiologists (ASA) class and postoperative outcomes following ASD surgery...
December 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29238607/protocol-for-a-feasibility-randomised-controlled-trial-of-the-use-of-physical-activity-monitors-in-an-exercise-referral-setting-the-pacers-study
#13
Jemma Hawkins, Michelle Edwards, Joanna Charles, Russell Jago, Mark Kelson, Kelly Morgan, Simon Murphy, Emily Oliver, Sharon Simpson, Rhiannon Tudor Edwards, Graham Moore
Background: Exercise referral schemes are recommended by the National Institute for Clinical Excellence (NICE) for physical activity promotion among inactive patients with health conditions or risk factors. Whilst there is evidence for the initial effectiveness and cost-effectiveness of such schemes for increasing physical activity, evidence of long-term effects is limited. Techniques such as goal setting, self-monitoring and personalised feedback may support motivation for physical activity...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29238536/body-macronutrient-composition-is-predicted-by-lipid-and-not-protein-content-of-the-diet
#14
Joshua P Moatt, Catherine Hambly, Elizabeth Heap, Anna Kramer, Fiona Moon, John R Speakman, Craig A Walling
Diet is an important determinant of fitness-related traits including growth, reproduction, and survival. Recent work has suggested that variation in protein:lipid ratio and particularly the amount of protein in the diet is a key nutritional parameter. However, the traits that mediate the link between dietary macronutrient ratio and fitness-related traits are less well understood. An obvious candidate is body composition, given its well-known link to health. Here, we investigate the relationship between dietary and body macronutrient composition using a first-generation laboratory population of a freshwater fish, the three-spine stickleback (Gasterosteus aculeatus)...
December 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29238442/reducing-greenhouse-gas-emissions-and-improving-air-quality-two-global-challenges
#15
REVIEW
Larry E Erickson
There are many good reasons to promote sustainable development and reduce greenhouse gas emissions and other combustion emissions. The air quality in many urban environments is causing many premature deaths because of asthma, cardiovascular disease, chronic obstructive pulmonary disease, lung cancer, and dementia associated with combustion emissions. The global social cost of air pollution is at least $3 trillion/year; particulates, nitrogen oxides and ozone associated with combustion emissions are very costly pollutants...
July 2017: Environmental Progress & Sustainable Energy
https://www.readbyqxmd.com/read/29238422/electronic-questionnaires-design-and-implementation
#16
REVIEW
Clara Minto, Giulia Beltrame Vriz, Matteo Martinato, Dario Gregori
Background: Nursing and health care research are increasingly using e-questionnaires and e-forms for data collection and survey conduction. The main reason lies in costs, time and data-entry errors containment, increased flexibility, functionality and usability. In spite of this growing usage, no specifc and comprehensive guidelines for designing and submitting e-questionnaires have been produced so far. Objective: The aim of this review is to collect information on the current best practices, taking them from various fields of application...
2017: Open Nursing Journal
https://www.readbyqxmd.com/read/29238222/the-burden-of-selected-cancers-in-the-us-health-behaviors-and-health-care-resource-utilization
#17
Laura Iadeluca, Jack Mardekian, Pratibha Chander, Markay Hopps, Geoffrey T Makinson
Objective: To characterize the disease burden among survivors of those cancers having the highest incidence in the US. Methods: Adult (≥18 years) survivors of the 11 most frequently diagnosed cancers were identified from publically available data sources, including the Surveillance Epidemiology and End Results 9 1973-2012, National Health Interview Survey 2013, and the Medical Expenditure Panel Survey 2011. Chi-square tests and one-way analyses of variance were utilized to assess differences between cancer survivors and non-cancer controls in behavioral characteristics, symptoms and functions, preventative screenings, and health care costs...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/29237581/a-web-based-training-resource-for-therapists-to-deliver-an-evidence-based-exercise-program-for-rheumatoid-arthritis-of-the-hand-isarah-design-development-and-usability-testing
#18
Cynthia Swarnalatha Srikesavan, Esther Williamson, Lucy Eldridge, Peter Heine, Jo Adams, Tim Cranston, Sarah E Lamb
BACKGROUND: The Strengthening and Stretching for Rheumatoid Arthritis of the Hand (SARAH) is a tailored, progressive exercise program for people having difficulties with wrist and hand function due to rheumatoid arthritis (RA). The program was evaluated in a large-scale clinical trial and was found to improve hand function, was safe to deliver, and was cost-effective. These findings led to the SARAH program being recommended in the UK National Institute for Health and Care Excellence guidelines for the management of adults with RA...
December 13, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29237508/making-healthy-homes-a-pilot-study-of-the-return-on-investment-from-an-external-wall-insulation-intervention
#19
Heather Brown, Gulnar Fattakhova, Clare Bambra, Paul Taylor
OBJECTIVES: External Wall Insulation (EWI) insulates and protect homes against damp. The Energy Company Obligation (ECO) scheme incentivised large energy providers in the UK delivering energy efficiency measures such as EWI to fuel impoverished households. Return on Investment (ROI) analysis is utilised to determine if EWI is a cost-effective procedure in terms of improving health related quality of life (HRQOL) measured using the EQ-5D-3L™, reducing health care expenditure, and fuel costs...
December 13, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29237493/the-association-between-health-insurance-status-and-utilization-of-health-services-in-rural-northern-ghana-evidence-from-the-introduction-of-the-national-health-insurance-scheme
#20
Philip Ayizem Dalinjong, Paul Welaga, James Akazili, Anthony Kwarteng, Martin Bangha, Abraham Oduro, Osman Sankoh, Jane Goudge
BACKGROUND: Many households in low- and middle-income countries face financial hardships due to payments for health care, while others are pushed into poverty. Risk pooling and prepayment mechanisms help to lessen the impact of the costs of care as well as assisting to achieve universal health coverage (UHC). Ghana implemented the National Health Insurance Scheme (NHIS) for the promotion of access to health services for all Ghanaians. In this paper, we examined the association between health insurance status and utilization of outpatient and inpatient health services in rural poor communities...
December 13, 2017: Journal of Health, Population, and Nutrition
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