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https://www.readbyqxmd.com/read/29031127/patients-perceptions-and-experiences-of-living-with-a-surgical-wound-healing-by-secondary-intention-a-qualitative-study
#1
Dorothy McCaughan, Laura Sheard, Nicky Cullum, Jo Dumville, Ian Chetter
BACKGROUND: Most surgical wounds heal by primary intention, that is to say, the edges of the wound are brought together with sutures, staples, adhesive glue or clips. However, some wounds may be left open to heal (if there is a risk of infection, or if there has been significant tissue loss), and are known as 'surgical wounds healing by secondary intention'. They are estimated to comprise approximately 28% of all surgical wounds and are frequently complex to manage. However, they are under researched and little is known of their impact on patients' lives...
September 28, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29031037/-evaluation-of-anti-cancer-therapies-with-reimbursement-limited-to-comprehensive-cancer-centres-using-the-european-society-for-medical-oncology-magnitude-of-clinical-benefit-scale
#2
T Büchler, B Melichar, D Vrána, R Lemstrová, J Fínek, L Dušek, K Petráková, J Prausová
BACKGROUND: The costs of oncology treatments are increasing, due to the rising prevalence of malignant diseases and the introduction of expensive novel anti-cancer agents. The new European Society for Clinical Oncology (ESMO) has recently developed a new parametric system to evaluate the clinical benefit of drugs. The Magnitude of Clinical Benefit Scale (ESMO-MCBS) compares the contribution of a novel drug based on overall and progression-free survival and quality of life with those of current treatment options...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29029246/the-epidermal-growth-factor-network-role-in-oocyte-growth-maturation-and-developmental-competence
#3
Dulama Richani, Robert B Gilchrist
BACKGROUND: The LH surge induces great physiological changes within the preovulatory follicle, which culminate in the ovulation of a mature oocyte that is capable of supporting embryo and foetal development. However, unlike mural granulosa cells, the oocyte and its surrounding cumulus cells are not directly responsive to LH, indicating that the LH signal is mediated by secondary factors produced by the granulosa cells. The mechanisms by which the oocyte senses the ovulatory LH signal and hence prepares for ovulation has been a subject of considerable controversy for the past four decades...
September 20, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/29029103/cardiovascular-disease-prevention-policy-in-hiv-recommendations-from-a-modelling-study
#4
Mikaela Smit, Rosan A van Zoest, Brooke E Nichols, Ilonca Vaartjes, Colette Smit, Marc van der Valk, Ard van Sighem, Ferdinand W Wit, Timothy B Hallett, Peter Reiss
Background: Cardiovascular disease (CVD) is expected to contribute a large non-communicable disease burden amongst HIV-positive people. We quantify the impact of prevention interventions on annual CVD burden and costs amongst HIV-positive people in The Netherlands. Methods: We constructed an individual-based model of CVD in HIV-positive people using national ATHENA cohort data on 8,791 patients on combination antiretroviral therapy (cART). The model follows patients as they age, develop CVD (by incorporating a CVD risk equation) and start cardiovascular medication...
October 6, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29029086/hiv-prevention-costs-and-their-predictors-evidence-from-the-orphea-project-in-kenya
#5
Omar Galárraga, Richard G Wamai, Sandra G Sosa-Rubí, Mercy G Mugo, David Contreras-Loya, Sergio Bautista-Arredondo, Helen Nyakundi, Joseph K Wang'ombe
We estimate costs and their predictors for three HIV prevention interventions in Kenya: HIV testing and counselling (HTC), prevention of mother-to-child transmission (PMTCT) and voluntary medical male circumcision (VMMC). As part of the 'Optimizing the Response of Prevention: HIV Efficiency in Africa' (ORPHEA) project, we collected retrospective data from government and non-governmental health facilities for 2011-12. We used multi-stage sampling to determine a sample of health facilities by type, ownership, size and interventions offered totalling 144 sites in 78 health facilities in 33 districts across Kenya...
September 26, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29029063/impact-of-pneumococcal-vaccination-on-pneumonia-hospitalizations-and-related-costs-in-ontario-a-population-based-ecological-study
#6
Dara Lee Luca, Jeffrey C Kwong, Anna Chu, Beate Sander, Ryan O'Reilly, Allison J McGeer, David E Bloom
Background: In Ontario, Canada, pneumococcal conjugate vaccine (PCV) was approved for infants in 2001 and became part of the publicly funded routine immunization schedule in 2005. We assessed the population-level impact of PCV on pneumonia hospitalizations and related costs. Methods: We used the difference-in-differences (DD) approach to evaluate the impact of pneumococcal vaccination on pneumonia hospitalizations and related costs, using non-pneumonia hospitalization as the control condition...
September 26, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29028964/the-cost-effectiveness-of-hiv-testing-and-treatment-engagement-initiatives-in-british-columbia-canada-2011-2013
#7
B Nosyk, J E Min, E Krebs, X Zang, M Compton, R Gustafson, R Barrios, J S G Montaner
Background: Recognition of the secondary preventive benefits of antiretroviral therapy (ART) has mobilized global efforts to 'seek, test, treat and retain' people living with HIV/AIDS (PLHIV) in HIV care. We aimed to determine the cost-effectiveness of a set of HIV testing and treatment engagement interventions initiated in British Columbia (BC), Canada in 2011-2013. Methods: Using a previously-validated dynamic, compartmental HIV transmission model, linked individual-level health administrative data for PLHIV and aggregate-level HIV testing data, we estimated the cost-effectiveness of primary care testing (hospital, emergency department, outpatient), ART initiation and ART retention initiatives, versus a counterfactual scenario approximating the status quo...
September 26, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29028755/finding-resolution-for-the-responsible-transparency-of-economic-models-in-health-and-medicine
#8
William V Padula, Robert Brett McQueen, Peter J Pronovost
The Second Panel on Cost-Effectiveness in Health and Medicine recommendations for conduct, methodological practices, and reporting of cost-effectiveness analyses has a number of questions unanswered with respect to the implementation of transparent, open source code interface for economic models. The possibility of making economic model source code could be positive and progressive for the field; however, several unintended consequences of this system should be first considered before complete implementation of this model...
November 2017: Medical Care
https://www.readbyqxmd.com/read/29028754/can-economic-model-transparency-improve-provider-interpretation-of-cost-effectiveness-analysis-a-response
#9
Joshua T Cohen, John B Wong
To enhance the credibility and the value of health economic analyses, we argue that the computer model source code underlying these analyses should be made publicly available. Only with open publication is it possible for others to assess whether alternative assumptions, beyond those examined by the model authors, alter the model's findings. Because reproducibility is critical for scientific acceptance and because computation increasingly permeates scientific inquiry, other fields have moved toward open publication of computer models, and health economics should avoid falling behind...
November 2017: Medical Care
https://www.readbyqxmd.com/read/29028753/can-economic-model-transparency-improve-provider-interpretation-of-cost-effectiveness-analysis-evaluating-tradeoffs-presented-by-the-second-panel-on-cost-effectiveness-in-health-and-medicine
#10
William V Padula, Robert Brett McQueen, Peter J Pronovost
The Second Panel on Cost-Effectiveness in Health and Medicine convened on December 7, 2016 at the National Academy of Medicine to disseminate their recommendations for conduct, methodological practices, and reporting of cost-effectiveness analyses (CEAs). Following its summary, panel proceedings included lengthy discussions including the field's struggle to disseminate findings efficiently through peer-reviewed literature to target audiences. With editors of several medical and outcomes research journals in attendance, there was consensus that findings of cost-effectiveness analyses do not effectively reach other researchers or health care providers...
November 2017: Medical Care
https://www.readbyqxmd.com/read/29028576/bioelectrochromic-hydrogel-for-fast-antibiotic-susceptibility-testing
#11
Ferran Pujol-Vila, Jiri Dietvorst, Laura Gall-Mas, María Díaz-González, Núria Vigués, Jordi Mas, Xavier Muñoz-Berbel
Materials science offers new perspectives in the clinical analysis of antimicrobial sensitivity. However, a biomaterial with the capacity to respond to living bacteria has not been developed to date. We present an electrochromic iron(III)-complexed alginate hydrogel sensitive to bacterial metabolism, here applied to fast antibiotic-susceptibility determination. Bacteria under evaluation are entrapped -and pre-concentrated- in the hydrogel matrix by oxidation of iron (II) ions to iron (III) and in situ formation of the alginate hydrogel in less than 2min and in soft experimental conditions (i...
September 6, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29028275/exposure-reductions-associated-with-introduction-of-solar-lamps-to-kerosene-lamp-using-households-in-busia-county-kenya
#12
Nicholas L Lam, Godfrey Muhwezi, Fred Isabirye, Kat Harrison, Ilse Ruiz-Mercado, Evans Amukoye, Tom Mokaya, Margaret Wambua, Michael N Bates
INTRODUCTION: Solar lamps are a clean and potentially cost-effective alternative to polluting kerosene lamps used by millions of families in developing countries. By how much solar lamps actually reduce exposure to pollutants, however, has not been examined. METHODS: Twenty households using mainly kerosene for lighting were enrolled through a secondary school in Busia County, Kenya. Personal PM2.5 and CO concentrations were measured on a school pupil and an adult in each household, before and after provision of three solar lamps...
October 13, 2017: Indoor Air
https://www.readbyqxmd.com/read/29028241/-du-bist-was-du-isst-challenges-in-european-nutrition-policy
#13
Alessandra Lafranconi, Christopher A Birt
Food cultures have developed in communities as according to the produce of local farms in the vicinity. The industrial revolution resulted in large cities and towns becoming reliant on farm produce from the neighbouring countryside; this stimulated development of farming, which itself became industrialized. However, although local diets in Europe differed markedly, the 'healthiness' of all diets was unquestioned until recently. Early in the 20th century, academic departments studying nutrition were established, but it is only since the 1980s that much interest in the 'healthiness' of our food began to be of concern outwith academia...
October 1, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29027867/unplanned-readmission-within-90-days-after-pediatric-neurosurgery
#14
Silky Chotai, Bradley S Guidry, Emily W Chan, Katherine D Sborov, Stephen Gannon, Chevis Shannon, Christopher M Bonfield, John C Wellons, Robert P Naftel
OBJECTIVE Readmission and return to operating room after surgery are increasingly being used as a proxy for quality of care. Nearly 60% of these readmissions are unplanned, which translates into billions of dollars in health care costs. The authors set out to analyze the incidence of readmission at their center, to define causes of unplanned readmission, and to determine the preoperative and surgical variables associated with readmissions following pediatric neurosurgery. METHODS A total of 536 children who underwent operations for neurosurgical diagnoses between 2012 and 2015 and who were later readmitted were included in the final analysis...
October 13, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29027820/using-cost-effectiveness-analysis-to-quantify-the-value-of-genomic-based-diagnostic-tests-recommendations-for-practice-and-research
#15
Eldon Spackman, Sebastian Hinde, Laura Bojke, Katherine Payne, Mark Sculpher
AIMS: New sequencing technologies allow increased opportunities to use genomic-based diagnostic tests (genomic tests) in routine clinical practice, which will impact healthcare budgets and patients' outcomes. This article aims to generate a list of recommendations on how the principles and methods of cost-effectiveness analysis (CEA) can be used to quantify the costs and benefits of genomic tests. METHODS: A systematic literature search identified publications describing the use of CEA to evaluate genomic tests...
October 13, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/29027379/impact-of-omalizumab-in-children-from-a-middle-income-country-with-severe-therapy-resistant-asthma-a-real-life-study
#16
Paulo M Pitrez, Rodrigo G de Souza, Cristian Roncada, Joao P Heinzmann-Filho, Giovana Santos, Leonardo A Pinto, Marcus H Jones, Renato T Stein
BACKGROUND: Severe asthma in children is a global health problem. Severe therapy-resistant asthma (STRA) in children is a major clinical challenge due to persistent symptoms despite high doses of corticosteroids and results in high public health costs. Omalizumab (anti-IgE monoclonal antibody) has been described as an effective add-on therapy in these patients. The characteristics of children with STRA from low- and middle-income countries have scarcely been reported, and no real-life study has been published on the effects of omalizumab in this group of patients...
October 13, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29027315/cost-effectiveness-analysis-of-carbetocin-during-cesarean-section-in-a-high-volume-maternity-unit
#17
Hian Yan Voon, Asrul A Shafie, Mohamad A Bujang, Haris N Suharjono
AIM: To evaluate the cost effectiveness of carbetocin compared to oxytocin when used as prophylaxis against post-partum hemorrhage (PPH) during cesarean deliveries. METHODS: A systematic review of the literature was performed to identify randomized controlled trials that compared the use of carbetocin to oxytocin in the context of cesarean deliveries. Cost effectiveness analysis was then performed using secondary data from the perspective of a maternity unit within the Malaysian Ministry of Health, over a 24 h time period...
October 13, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29027127/use-of-supplementary-patient-education-material-increases-treatment-adherence-and-satisfaction-among-acne-patients-receiving-adapalene-0-1-benzoyl-peroxide-2-5-gel-in-primary-care-clinics-a-multicenter-randomized-controlled-clinical-study
#18
Timothy Myhill, Warwick Coulson, Paul Nixon, Simon Royal, Terry McCormack, Nabil Kerrouche
INTRODUCTION: Poor adherence to acne treatment may lead to unnecessary treatments, increased healthcare costs, and reduced quality of life (QoL). This multicenter study evaluated the effect of supplementary patient education material (SEM) (a short video, information card, and additional information available online) on treatment adherence and satisfaction among acne patients treated with the fixed-dose combination adapalene 0.1%/benzoyl peroxide 2.5% gel (A/BPO) in primary care clinics versus (1) standard-of-care patient education (SOCPE) (package insert and oral instruction) and (2) SOCPE plus more frequent clinic visits...
October 12, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29026666/bedside-twist-drill-aspiration-of-cerebral-abscess-less-than-2-5-cm-in-size-a-case-series-and-discussion
#19
Tyler Carson, Dan Miulli
BACKGROUND: Intracranial abscess remains a potentially deadly condition despite development of newer antibiotics and improved surgical methods. Many studies have evaluated the surgical indications for abscess drainage, and it has been generally accepted that intracranial abscesses greater than 2.5 cm may best be treated with surgical intervention followed by antibiotic therapy. More recently, studies have shown good results with stereotactic aspiration of abscesses to 1 cm in size. Furthermore, a recent case series in 2014 of 103 cases of bedside twist drill aspiration of cerebral abscess >2...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29026483/hospital-charges-and-continuity-of-care-for-outpatients-with-hypertension-in-south-korea-a-nationwide-population-based-cohort-study-from-2002-to-2013
#20
Jae-Hyun Kim, Eun-Cheol Park, Tae Hyun Kim, Yunhwan Lee
BACKGROUND: Continuity of care (COC) has received attention over the past decade. COC has also become increasingly important for hospital managers and policy makers because of competitive health care market conditions. The purpose of this study was to assess the association between hospital charges and patients' continuity of care-assessed by three indices of continuity of care-among outpatients with hypertension in South Korea. METHODS: This study used the National Health Insurance Service-Cohort Sample Database from 2002 to 2013...
September 2017: Korean Journal of Family Medicine
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