keyword
MENU ▼
Read by QxMD icon Read
search

odorant receptor

keyword
https://www.readbyqxmd.com/read/29449815/combinatorial-codes-and-labeled-lines-how-insects-use-olfactory-cues-to-find-and-judge-food-mates-and-oviposition-sites-in-complex-environments
#1
REVIEW
Alexander Haverkamp, Bill S Hansson, Markus Knaden
Insects, including those which provide vital ecosystems services as well as those which are devastating pests or disease vectors, locate their resources mainly based on olfaction. Understanding insect olfaction not only from a neurobiological but also from an ecological perspective is therefore crucial to balance insect control and conservation. However, among all sensory stimuli olfaction is particularly hard to grasp. Our chemical environment is made up of thousands of different compounds, which might again be detected by our nose in multiple ways...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29447665/preparation-of-molecularly-imprinted-polymer-nanobeads-for-selective-sensing-of-carboxylic-acid-vapors
#2
Chuanjun Liu, Liang Shang, Hiro-Taka Yoshioka, Bin Chen, Kenshi Hayashi
The detection and discrimination of volatile carboxylic acid components, which are the main contributors to human body odor, have a wide range of potential applications. Here, a quartz crystal microbalance (QCM) sensor array based on molecularly imprinted polymer (MIP) nanobeads is developed for highly sensitive and selective sensing of typical carboxylic acid vapors, namely: propionic acid (PA), hexanoic acid (HA) and octanoic acid (OA). The MIP nanobeads were prepared by precipitation polymerization with methacrylic acid (MAA) as a functional monomer, trimethylolproane trimethacrylate (TRIM) as a crosslinker, and carboxylic acids (PA, HA and OA) as the template molecules...
June 20, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29438653/stereochemical-study-of-mouse-muscone-receptor-mor215-1-and-vibrational-theory-based-on-statistical-physics-formalism
#3
Ismahene Ben Khemis, Nesrine Mechi, Abdelmottaleb Ben Lamine
In the biosensor system, olfactory receptor sites could be activated by odorant molecules and then the biological interactions are converted into electrical signals by a signal transduction cascade that leads the toopening of ion channels, generating a current that leads into the cilia and depolarizes the membrane. The aim of this paper is to present a new investigation that allows determining the olfactory band using a monolayer adsorption with identical sites modeling which may also describe the static and the dynamic sensitivities through the expression of the olfactory response...
February 10, 2018: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/29429938/signaling-mode-of-the-broad-spectrum-conserved-co2-receptor-is-one-of-the-important-determinants-of-odor-valence-in-drosophila
#4
Dyan MacWilliam, Joel Kowalewski, Arun Kumar, Crystal Pontrello, Anandasankar Ray
Odor detection involves hundreds of olfactory receptors from diverse families, making modeling of hedonic valence of an odorant difficult, even in Drosophila melanogaster where most receptors have been deorphanised. We demonstrate that a broadly tuned heteromeric receptor that detects CO2 (Gr21a, Gr63a) and other odorants is a key determinant of valence along with a few members of the Odorant receptor family in a T-maze, but not in a trap assay. Gr21a and Gr63a have atypically high amino acid conservation in Dipteran insects, and they use both inhibition and activation to convey positive or negative valence for numerous odorants...
February 7, 2018: Neuron
https://www.readbyqxmd.com/read/29429617/spatial-receptive-fields-for-odor-localization
#5
Hiroshi Nishino, Masazumi Iwasaki, Marco Paoli, Itsuro Kamimura, Atsushi Yoritsune, Makoto Mizunami
Animals rely on olfaction to navigate through complex olfactory landscapes, but the mechanisms that allow an animal to encode the spatial structure of an odorous environment remain unclear. To acquire information about the spatial distribution of an odorant, animals may rely on bilateral olfactory organs and compare side differences of odor intensity and timing [1-6] or may perform spatial and temporal signal integration of subsequent samplings [7]. The American cockroach can efficiently locate a source of sex pheromone even after the removal of one antenna, suggesting that bilateral comparison is not a prerequisite for odor localization in this species [8, 9]...
February 7, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29429152/mass-spectrometry-based-screening-platform-reveals-orco-interactome-in-drosophila-melanogaster
#6
Kate E Yu, Do-Hyoung Kim, Yong-In Kim, Walton D Jones, J Eugene Lee
Animals use their odorant receptors to receive chemical information from the environment. Insect odorant receptors differ from the G protein-coupled odorant receptors in vertebrates and nematodes, and very little is known about their protein-protein interactions. Here, we introduce a mass spectrometric platform designed for the large-scale analysis of insect odorant receptor protein-protein interactions. Using this platform, we obtained the first Orco interactome from Drosophila melanogaster. From a total of 1,186 identified proteins, we narrowed the interaction candidates to 226, of which only two-thirds have been named...
February 12, 2018: Molecules and Cells
https://www.readbyqxmd.com/read/29421612/revisit-metaplasticity-the-roles-of-calcineurin-and-histone-deacetylation-in-unlearning-odor-preference-memory-in-rat-pups
#7
Sriya Bhattacharya, Bandhan Mukherjee, Jaqueline Blundell, Carolyn Harley, Qi Yuan
Previous work has shown that 24 h duration odor preference learning, induced by one-trial training, generates a down-regulation of the GluN1 receptor in anterior piriform cortex at 3 h, and results in metaplastic unlearning if a second training trial is given at 3 h. The GluN1 receptor upregulates at 24 h so 24 h spaced training is highly effective in extending memory duration. The present study replicates the piriform cortex unlearning result in the olfactory bulb circuit and further studies the relationship between the initial training strength and its associated metaplastic effect...
February 5, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29408363/dopamine-depletion-shifts-behavior-from-activity-based-reinforcers-to-more-sedentary-ones-and-adenosine-receptor-antagonism-reverses-that-shift-relation-to-ventral-striatum-darpp32-phosphorylation-patterns
#8
Laura López-Cruz, Noemí San Miguel, Carla Carratalá-Ros, Lidón Monferrer, John D Salamone, Mercè Correa
The mesolimbic dopamine (DA) system plays a critical role in behavioral activation and effort-based decision-making. DA depletion produces anergia (shifts to low effort options) in animals tested on effort-based decision-making tasks. Caffeine, the most consumed stimulant in the world, acts as an adenosine A1/A2A receptor antagonist, and in striatal areas DA D1 and D2 receptors are co-localized with adenosine A1 and A2A receptors respectively. In the present work, we evaluated the effect of caffeine on anergia induced by the VMAT-2 inhibitor tetrabenazine (TBZ), which depletes DA...
February 2, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29407371/g-protein-coupled-receptors-mc4r-and-drd1-can-serve-as-surrogate-odorant-receptors-in-mouse-olfactory-sensory-neurons
#9
Markella Katidou, Xavier Grosmaitre, Jiangwei Lin, Peter Mombaerts
In the mouse, most mature olfactory sensory neurons (OSNs) express one allele of one gene from the repertoire of ~1100 odorant receptor (OR) genes, which encode G-protein coupled receptors (GPCRs). Axons of OSNs that express a given OR coalesce into homogeneous glomeruli, which reside at conserved positions in the olfactory bulb. ORs are intimately involved in ensuring the expression of one OR per OSN and the coalescence of OSN axons into glomeruli. But the mechanisms whereby ORs accomplish these diverse functions remain poorly understood...
January 30, 2018: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/29395917/modulation-of-host-learning-in-aedes-aegypti-mosquitoes
#10
Clément Vinauger, Chloé Lahondère, Gabriella H Wolff, Lauren T Locke, Jessica E Liaw, Jay Z Parrish, Omar S Akbari, Michael H Dickinson, Jeffrey A Riffell
How mosquitoes determine which individuals to bite has important epidemiological consequences. This choice is not random; most mosquitoes specialize in one or a few vertebrate host species, and some individuals in a host population are preferred over others. Mosquitoes will also blood feed from other hosts when their preferred is no longer abundant, but the mechanisms mediating these shifts between hosts, and preferences for certain individuals within a host species, remain unclear. Here, we show that olfactory learning may contribute to Aedes aegypti mosquito biting preferences and host shifts...
January 20, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29389166/effects-of-n-methyl-d-aspartate-nmda-antagonists-ketamine-methoxetamine-and-phencyclidine-on-the-odor-span-test-of-working-memory-in-rats
#11
Michael J Mathews, Ralph N Mead, Mark Galizio
The glutamate hypothesis proposes that N-Methyl-D-aspartate (NMDA) receptor hypofunction underlies cognitive and perhaps other schizophrenic symptoms. The present study used the odor span task to assess the effects of NMDA antagonists on remembering multiple stimuli in rodents. This task uses an incrementing nonmatching-to-sample procedure in which responses to a new olfactory stimulus are reinforced on each trial, whereas responses to previously presented stimuli are not. NMDA antagonists have been associated with memory impairments in a variety of animal models; however, there are inconsistencies across different NMDA antagonists and tasks used...
February 2018: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29385124/coordination-of-olfactory-receptor-choice-with-guidance-receptor-expression-and-function-in-olfactory-sensory-neurons
#12
Puneet Dang, Stephen A Fisher, Derek Stefanik, Junhyong Kim, Jonathan A Raper
Olfactory sensory neurons choose to express a single odorant receptor (OR) from a large gene repertoire and extend axons to reproducible, OR-specific locations within the olfactory bulb. This developmental process produces a topographically organized map of odorant experience in the brain. The axon guidance mechanisms that generate this pattern of connectivity, as well as those that coordinate OR choice and axonal guidance receptor expression, are incompletely understood. We applied the powerful approach of single-cell RNA-seq on newly born olfactory sensory neurons (OSNs) in young zebrafish larvae to address these issues...
January 31, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29373972/differential-gene-expression-in-the-evolution-of-sex-pheromone-communication-in-new-zealand-s-endemic-leafroller-moths-of-the-genera-ctenopseustis-and-planotortrix
#13
Alessandro Grapputo, Amali H Thrimawithana, Bernd Steinwender, Richard D Newcomb
BACKGROUND: Sex pheromone communication in moths has attracted the attention of evolutionary biologists due to the vast array of pheromone compounds used, addressing questions of how this diversity arose and how male reception has evolved in step with the female signal. Here we examine the role of changing gene expression in the evolution of mate recognition systems in leafroller moths, particularly focusing on genes involved in the biosynthetic pathways of sex pheromones in female pheromone glands and the peripheral reception repertoire in the antennae of males...
January 26, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29349576/prep1-deficiency-affects-olfactory-perception-and-feeding-behavior-by-impairing-bdnf-trkb-mediated-neurotrophic-signaling
#14
Serena Ricci, Davide Viggiano, Ilaria Cimmino, Giuseppe Perruolo, Serena Cabaro, Antonietta Liotti, Francesca Fiory, Rosa Spinelli, Angelina Di Carlo, Francesco Beguinot, Pietro Formisano, Francesco Oriente
Prep1 is a homeodomain transcription factor which has an important role in hindbrain development. Prep1 expression is also kept in adult mouse brain and in particular within the olfactory bulbs. Moreover, many Prep1 neurons co-localize with Calbindin-positive periglomerular interneurons in olfactory glomerular layer. However, Prep1 function in this brain region is still unknown. In this study, we show that Prep1 hypomorphic heterozygous (Prep1 i/+ ) mice express low levels of protein and feature a 30% reduction of olfactory bulb area, compared to WT mice...
January 18, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29313080/evolution-of-potent-odorants-within-the-volatile-metabolome-of-high-quality-hazelnuts-corylus-avellana-l-evaluation-by-comprehensive-two-dimensional-gas-chromatography-coupled-with-mass-spectrometry
#15
Marta Cialiè Rosso, Erica Liberto, Nicola Spigolon, Mauro Fontana, Marco Somenzi, Carlo Bicchi, Chiara Cordero
Within the pattern of volatiles released by food products (volatilome), potent odorants are bio-active compounds that trigger aroma perception by activating a complex array of odor receptors (ORs) in the regio olfactoria. Their informative role is fundamental to select optimal post-harvest and storage conditions and preserve food sensory quality. This study addresses the volatile metabolome from high-quality hazelnuts (Corylus avellana L.) from the Ordu region (Turkey) and Tonda Romana from Italy, and investigates its evolution throughout the production chain (post-harvest, industrial storage, roasting) to find functional correlations between technological strategies and product quality...
January 9, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29311316/reverse-chemical-ecology-approach-for-the-identification-of-an-oviposition-attractant-for-culex-quinquefasciatus
#16
Young-Moo Choo, Pingxi Xu, Justin K Hwang, Fangfang Zeng, Kaiming Tan, Ganga Bhagavathy, Kamlesh R Chauhan, Walter S Leal
Pheromones and other semiochemicals play a crucial role in today's integrated pest and vector management strategies. These semiochemicals are typically discovered by bioassay-guided approaches. Here, we applied a reverse chemical ecology approach; that is, we used olfactory proteins to lead us to putative semiochemicals. Specifically, we used 7 of the top 10 odorant receptors (ORs) most expressed in the antennae of the southern house mosquito, Culex quinquefasciatus, and which are yet to be deorphanized. We expressed these receptors in the Xenopus oocyte recording system and challenged them with a panel of 230 odorants, including physiologically and behaviorally active compounds...
January 23, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29304134/identification-of-chemosensory-genes-from-the-antennal-transcriptome-of-indian-meal-moth-plodia-interpunctella
#17
Xiaojian Jia, Xiaofang Zhang, Hongmin Liu, Rongyan Wang, Tao Zhang
Olfaction plays an indispensable role in mediating insect behavior, such as locating host plants, mating partners, and avoidance of toxins and predators. Olfactory-related proteins are required for olfactory perception of insects. However, very few olfactory-related genes have been reported in Plodia interpunctella up to now. In the present study, we sequenced the antennae transcriptome of P. interpunctella using the next-generation sequencing technology, and identified 117 candidate olfactory-related genes, including 29 odorant-binding proteins (OBPs), 15 chemosensory proteins (CSPs), three sensory neuron membrane proteins (SNMPs), 47 odorant receptors (ORs), 14 ionotropic receptors (IRs) and nine gustatory receptors (GRs)...
2018: PloS One
https://www.readbyqxmd.com/read/29301613/testing-olfactory-function-and-mapping-the-structural-olfactory-networks-in-the-brain
#18
Alexander Fjældstad
We perceive the world through our senses. The dependence on these sensory stimuli becomes obvious when we see a visually impaired individual with a guide dog or an individual using sign language. However, individuals with olfactory deficits suffer from a more concealed impairment without any opportunity for diagnostics or treatment in the Danish healthcare system. Around a fifth of the population experience olfactory deficits, of which 1-2% are functionally anosmic. The personal consequences for anosmics can be extensive, lacking not only in hedonic yield related to eating and drinking, but also the socialization during dinners can become niggling...
January 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29301263/applications-and-advances-in-bioelectronic-noses-for-odour-sensing
#19
REVIEW
Tran Thi Dung, Yunkwang Oh, Seon-Jin Choi, Min-Kyu Oh, Moonil Kim, Il-Doo Kim
A bioelectronic nose, an intelligent chemical sensor array system coupled with bio-receptors to identify gases and vapours, resembles mammalian olfaction by which many vertebrates can sniff out volatile organic compounds (VOCs) sensitively and specifically even at very low concentrations. Olfaction is undertaken by the olfactory system, which detects odorants that are inhaled through the nose where they come into contact with the olfactory epithelium containing olfactory receptors (ORs). Because of its ability to mimic biological olfaction, a bio-inspired electronic nose has been used to detect a variety of important compounds in complex environments...
January 1, 2018: Sensors
https://www.readbyqxmd.com/read/29290549/cholinergic-sensorimotor-integration-regulates-olfactory-steering
#20
He Liu, Wenxing Yang, Taihong Wu, Fengyun Duan, Edward Soucy, Xin Jin, Yun Zhang
Sensorimotor integration regulates goal-directed movements. We study the signaling mechanisms underlying sensorimotor integration in C. elegans during olfactory steering, when the sinusoidal movements of the worm generate an in-phase oscillation in the concentration of the sampled odorant. We show that cholinergic neurotransmission encodes the oscillatory sensory response and the motor state of head undulations by acting through an acetylcholine-gated channel and a muscarinic acetylcholine receptor, respectively...
December 21, 2017: Neuron
keyword
keyword
89450
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"