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https://www.readbyqxmd.com/read/29914355/motifome-comparison-between-modern-human-neanderthal-and-denisovan
#1
Matyas F Cserhati, Mary-Ellen Mooter, Lauren Peterson, Benjamin Wicks, Peng Xiao, Mark Pauley, Chittibabu Guda
BACKGROUND: The availability of the genomes of two archaic humans, Neanderthal and Denisovan, and that of modern humans provides researchers an opportunity to investigate genetic differences between these three subspecies on a genome-wide scale. Here we describe an algorithm that predicts statistically significant motifs based on the difference between a given motif's actual and expected distributions. The algorithm was previously applied to plants but was modified for this work. RESULTS: The result of applying the algorithm to the human, Neanderthal, and Denisovan genomes is a catalog of potential regulatory motifs in these three human subspecies...
June 18, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29908099/pathogenesis-of-primordial-odontogenic-tumour-based-on-tumourigenesis-and-odontogenesis
#2
Toshinari Mikami, Ronell Bologna-Molina, Adalberto Mosqueda-Taylor, Ikuko Ogawa, Vanesa Pereira-Prado, Naoki Fujiwara, Fabio Ramoa Pires, Roman Carlos, Takashi Takata, Yasunori Takeda
OBJECTIVE: Primordial odontogenic tumour (POT) is a rare benign mixed epithelial and mesenchymal odontogenic tumour. POT is composed of dental papilla-like tissue covered with cuboidal to columnar epithelium that resembles to inner and outer enamel epithelium of the enamel organ without dental hard tissue formation. The aim of this study was to examine pathogenesis of POT based on tumourigenesis and odontogenesis. SUBJECTS AND METHODS: Six cases of POT were submitted for study...
June 16, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29891419/micro-ct-evaluation-of-marginal-and-internal-fit-of-cemented-polymer-infiltrated-ceramic-network-material-crowns-manufactured-after-conventional-and-digital-impressions
#3
Rinet Dauti, Barbara Cvikl, Bledar Lilaj, Patrick Heimel, Andreas Moritz, Andreas Schedle
PURPOSE: Purpose of this study was to evaluate the accuracy of fit of cemented polymer infiltrated ceramic network (PICN) material crowns manufactured after digital and conventional impression techniques using micro computed tomography (CT). Furthermore to determine the cement space volume and porosities in the cement layer. METHODS: A molar typodont tooth was prepared for PICN material crowns and replicated thirty times. The dies were randomly divided into three groups of 10 specimens each according to the impression technique: 3M True Definition Scanner (TDS), cara TRIOS (Trios) and Impregum Penta Soft (Impregum)...
June 8, 2018: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/29873575/evaluation-of-paromomycin-sulphate-permeation-using-ex-vivo-human-skin-model
#4
Enam A Khalil, Mahmoud Y Alkawareek, Ghadeer Othman, Bayan Tbakhi, Amal G Al-Bakri
Ex-vivo evaluation of drug release and skin permeation from topical formulations of antileishmanial drug paromomycin sulphate was carried out using intact full thickness human skin. Potency-based microbiological assay was used for the analysis of paromomycin concentrations. A total percentage drug recovery of 86±26% was obtained. Incubation periods of 1 and 3 hours resulted in percentage drug permeation into deep skin layers ranging from 1.3±0.04% to 5.3±2.0% with paraffin-based ointment and from 1.6±0...
June 6, 2018: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29790033/biomechanical-properties-of-polymer-infiltrated-ceramic-crowns-on-one-piece-zirconia-implants-after-long-term-chewing-simulation
#5
Pia Baumgart, Holger Kirsten, Rainer Haak, Constanze Olms
BACKGROUND: Implant and superstructure provide a complex system, which has to withstand oral conditions. Concerning the brittleness of many ceramics, fractures are a greatly feared issue. Therefore, polymer-infiltrated ceramic networks (PICNs) were developed. Because of its low Young's modulus and high elastic modulus, the PICN crown on a one-piece zirconia implant might absorb forces to prevent the system from fracturing in order to sustain oral forces. Recommendations for the material of superstructure on zirconia implants are lacking, and only one study investigates PICN crowns on these types of implants...
May 23, 2018: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/29777736/edge-strength-of-cad-cam-materials
#6
Maria Pfeilschifter, Verena Preis, Michael Behr, Martin Rosentritt
OBJECTIVES: To investigate the edge force of CAD/CAM materials as a function of (a) material, (b) thickness, and (c) distance from the margin. METHODS: Materials intended for processing with CAD/CAM were investigated: eight resin composites, one resin-infiltrated ceramic, and a clinically proven lithiumdisilicate ceramic (reference). To measure edge force (that is, load to failure/crack), plates (d = 1 mm) were fixed and loaded with a Vickers diamond indenter (1 mm/min, Zwick 1446) at a distance of 0...
May 16, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29773104/-knockdown-of-msx2-gene-inhibits-the-expression-of-enamel-matrix-proteins-and-the-enamel-mineralization-in-mouse-ameloblasts
#7
Hao Liu, Jianping Jiang, Qi Gong, Huanbing Tian, Sheng Wang, Juanjuan Zhang, Zhifang Pan, Xiaoying Liu
Objective To study the effect of muscle segment homeodomain homeobox 2 (MSX2) on the expression of enamel matrix protein and the formation of enamel. Methods Immunohistochemical staining was used to detect the expression of MSX2 in mouse tooth embryos and its localization in ameloblasts. The short hairpin RNA (shRNA) of the MSX2 gene was designed and synthesized, and then the annealed double stranded DNA was constructed into the pGMLV-SC5 RNAi lentivirus vector, and finally it was packaged with lentivirus. The lentivirus was used to infect ameloblasts...
March 2018: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/29770877/polishing-effects-and-wear-performance-of-chairside-cad-cam-materials
#8
Mike Matzinger, Sebastian Hahnel, Verena Preis, Martin Rosentritt
OBJECTIVES: To investigate the surface roughness of CAD/CAM materials immediately after milling and after different chairside and labside polishing procedures. A two-body wear test was performed to compare the different wear characteristics of the materials and the corresponding antagonists. MATERIALS AND METHODS: Specimens (n = 12 per series) from different CAD/CAM materials (three composites: Lava Ultimate, Cerasmart, BRILLIANT Crios; one hybrid ceramic: VITA Enamic; three ceramics: Celtra Duo, VITA Suprinity, IPS Emax...
May 16, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29740523/use-of-preoperative-apparent-diffusion-coefficients-to-predict-brain-tumor-grade
#9
Aneela Darbar, Muhammad Waqas, Syed Faaiz Enam, Shaikh D Mahmood
Introduction The apparent diffusion coefficient (ADC) sequence is based on the diffusion properties of water molecules within tissues and correlates with tissue cellularity. ADC may have a role in predicting tumor grade for gliomas, and may in turn assist in identifying tumor biopsy sites. The purpose of this investigation was to assess the competence of preoperative ADC values in predicting tumor grades. Methods This was a retrospective investigation. We calculated the ADC values in the areas of greatest restriction in solid tumor components, and we recorded the pattern of contrast enhancement...
March 7, 2018: Curēus
https://www.readbyqxmd.com/read/29724551/influence-of-low-temperature-degradation-on-the-wear-characteristics-of-zirconia-against-polymer-infiltrated-ceramic-network-material
#10
Zhichao Hao, Yuanyuan Ma, Wenjia Liu, Yukun Meng, Keisuke Nakamura, Jiefei Shen, Hang Wang
STATEMENT OF PROBLEM: Low-temperature degradation may affect zirconia restorations during their clinical service. Concerns have been raised about the effect of low-temperature degradation on the wear behavior of zirconia. Moreover, the wear resistance of this novel polymer-infiltrated ceramic-network material needs to be better evaluated. PURPOSE: The purpose of this in vitro study was to investigate the influence of aging on the wear resistance of zirconia opposing polymer-infiltrated ceramic-network material...
April 30, 2018: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/29724550/effect-of-different-resin-cements-and-surface-treatments-on-the-shear-bond-strength-of-ceramic-glass-polymer-materials
#11
Gülce Alp, Meryem Gülce Subaşı, William M Johnston, Burak Yilmaz
STATEMENT OF PROBLEM: The effect of different surface treatment techniques on the bond strength of different types of ceramic-glass polymer computer-assisted design and computer-assisted manufacturing (CAD-CAM) materials and resin cements after aging is unknown. PURPOSE: The purpose of this in vitro study was to evaluate the surface roughness of different ceramic-glass polymer CAD-CAM materials after 2 different surface treatments and the effect of material, surface treatment, resin cement, and aging on bond strength...
April 30, 2018: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/29720593/nano-photothermal-ablation-effect-of-hydrophilic-and-hydrophobic-functionalized-gold-nanorods-on-staphylococcus-aureus-and-propionibacterium-acnes
#12
Nouf N Mahmoud, Alaaldin M Alkilany, Enam A Khalil, Amal G Al-Bakri
The potential photothermal bactericidal activity of hydrophilic functionalized poly ethylene glycol (PEG)-gold nanorods (GNR) and hydrophobic functionalized polystyrene (PS)-GNR was evaluated towards strains of Staphylococcus aureus (S. aureus) and Propionibacterium acnes (P. acnes) by measuring the percentage reduction of bacterial viable count upon GNR excitation with a near infra-red (NIR) laser beam. Our results suggest that functionalized GNR had a minimal bactericidal activity against S. aureus and P...
May 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29714496/prosthetically-driven-computer-guided-implant-placement-and-restoration-using-cerec-a-case-report
#13
David Dano, Monica Stiteler, Russell Giordano
Developments in 3-dimentional (3D) diagnostic technology and advanced digital optical imaging have improved the predictability, safety, and efficiency of restoratively driven implant dentistry. Surgical procedures may now be performed in a single visit utilizing chairside, computer-aided design/computer-aided manufacturing technology and in situations when a two-stage implant protocol is indicated as demonstrated in this case. The CEREC® GALILEOS® integration workflow system was used to prosthetically plan and place an implant in the lower right mandibular first molar site, No...
May 2018: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/29678328/chairside-cad-cam-materials-part-3-cyclic-fatigue-parameters-and-lifetime-predictions
#14
Michael Wendler, Renan Belli, Diana Valladares, Anselm Petschelt, Ulrich Lohbauer
OBJECTIVES: Chemical and mechanical degradation play a key role on the lifetime of dental restorative materials. Therefore, prediction of their long-term performance in the oral environment should base on fatigue, rather than inert strength data, as commonly observed in the dental material's field. The objective of the present study was to provide mechanistic fatigue parameters of current dental CAD/CAM materials under cyclic biaxial flexure and assess their suitability in predicting clinical fracture behaviors...
June 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29661579/effect-of-acid-etching-on-tridimensional-microstructure-of-etchable-cad-cam-materials
#15
Fabián Murillo-Gómez, Regina Guenka Palma-Dibb, Mario Fernando De Goes
OBJECTIVE: Evaluate if etching protocols affect superficial/internal microstructural integrity of CAD/CAM ceramic materials. METHODS: Sixty blocks (3×3×3mm) of IPS/Empress-LEU, IPS/e.max-LDC (Ivoclar-Vivadent) and Enamic-PIC (VITA) were used. Lateral surfaces from each block were isolated with Teflon strip and petroleum jelly to keep them untouched. Specimens were distributed into 6 groups (n=10): 1. no treatment (C); 2. hydrofluoric acid (HF) 5%, 20s (HF5%20s); 3...
June 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29593332/the-importance-of-a-potential-phosphorylation-site-in-enamelin-on-enamel-formation
#16
Wen-Juan Yan, Pan Ma, Ye Tian, Jing-Ya Wang, Chun-Lin Qin, Jian Q Feng, Xiao-Fang Wang
Enamelin (ENAM) has three putative phosphoserines (pSers) phosphorylated by a Golgi-associated secretory pathway kinase (FAM20C) based on their distinctive Ser-x-Glu (S-x-E) motifs. Fam20C-knockout mice show severe enamel defects similar to those in the Enam-knockout mice, implying an important role of the pSers in ENAM. To determine the role of pSer55 in ENAM, we characterized ENAMRgsc514 mice, in which Ser55 cannot be phosphorylated by FAM20C due to an E57 >G57 mutation in the S-x-E motif. The enamel microstructure of 4-week-old mice was examined by scanning electron microscopy...
November 29, 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/29554435/hypoplastic-ai-with-highly-variable-expressivity-caused-by-enam-mutations
#17
M Koruyucu, J Kang, Y J Kim, F Seymen, Y Kasimoglu, Z H Lee, T J Shin, H K Hyun, Y J Kim, S H Lee, J C C Hu, J P Simmer, J W Kim
Tooth enamel, the hardest tissue in the human body, is formed after a complex series of interactions between dental epithelial tissue and the underlying ectomesenchyme. Nonsyndromic amelogenesis imperfecta (AI) is a rare genetic disorder affecting tooth enamel without other nonoral symptoms. In this study, we identified 2 novel ENAM mutations in 2 families with hypoplastic AI by whole exome sequencing. Family 1 had a heterozygous splicing donor site mutation in intron 4, NM_031889; c.123+2T>G. Affected individuals had hypoplastic enamel with or without the characteristic horizontal hypoplastic grooves in some teeth...
March 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29534712/effect-of-surface-finishing-on-the-colour-stability-and-translucency-of-dental-ceramics
#18
Işıl Sarıkaya, Kaan Yerliyurt, Yeliz Hayran
BACKGROUND: The purpose of this study was to investigate the effects of staining solutions and surface finishing on the colour stability and translucency of hybrid ceramic (HC) and resin nanoceramic (RNC) materials. METHODS: Twenty four groups consisting of 10 specimens (240 specimens in total) were created out of HC and RNC, including six groups to be stored in distilled water served as the controls groups. The Vita Enamic technical set, Shofu polishers, medium and fine rubber wheels and Sof-Lex polishing discs were used as polishing instruments...
March 13, 2018: BMC Oral Health
https://www.readbyqxmd.com/read/29519990/-in-vitro-fracture-strength-and-hardness-of-different-computer-aided-design-computer-aided-manufacturing-inlays
#19
O Sagsoz, M Yildiz, A S L Hojjat Ghahramanzadeh, A Alsaran
Objective: The purpose of this study was to examine the fracture strength and surface microhardness of computer-aided design/computer-aided manufacturing (CAD/CAM) materials in vitro. Materials and Methods: Mesial-occlusal-distal inlays were made from five different CAD/CAM materials (feldspathic ceramic, CEREC blocs; leucite-reinforced ceramic, IPS Empress CAD; resin nano ceramic, 3M ESPE Lava Ultimate; hybrid ceramic, VITA Enamic; and lithium disilicate ceramic, IPS e...
March 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29513638/effect-of-different-computer-aided-design-computer-aided-manufacturing-cad-cam-materials-and-thicknesses-on-the-fracture-resistance-of-occlusal-veneers
#20
J P Andrade, D Stona, H R Bittencourt, G A Borges, L H Burnett, A M Spohr
The aim was to evaluate, in vitro, the influence of different computer-aided design/computer-aided manufacturing (CAD/CAM) materials (IPS e.max CAD, Vita Enamic, and Lava Ultimate) and thicknesses (0.6 mm and 1.5 mm) on the fracture resistance of occlusal veneers. Sixty human third molars were prepared to simulate advanced erosion of the occlusal surface, and the teeth were randomly divided into six experimental groups (n=10) according to the material and thickness used to build the veneers. Ten sound teeth formed the control group...
March 7, 2018: Operative Dentistry
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