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Bile salt diarrhea

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https://www.readbyqxmd.com/read/28348056/analysis-of-shigella-flexneri-resistance-biofilm-formation-and-transcriptional-profile-in-response-to-bile-salts
#1
Kourtney P Nickerson, Rachael B Chanin, Jeticia R Sistrunk, David A Rasko, Peter J Fink, Eileen M Barry, James P Nataro, Christina S Faherty
The Shigella species cause millions of cases of watery or bloody diarrhea each year, mostly in children in developing countries. While many aspects of Shigella colonic cell invasion are known, crucial gaps in knowledge regarding how the bacteria survive, transit, and regulate gene expression prior to infection remain. In this study, we define mechanisms of resistance to bile salts and build on previous research highlighting induced virulence in Shigella flexneri strain 2457T following exposure to bile salts...
June 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28316592/influence-of-stress-factors-related-to-cheese-making-process-and-to-stec-detection-procedure-on-the-induction-of-stx-phages-from-stec-o26-h11
#2
Ludivine Bonanno, Benjamin Delubac, Valérie Michel, Frédéric Auvray
Shiga toxin-producing Escherichia coli (STEC) are responsible for human infections, ranging from mild watery diarrhea to hemorrhagic colitis (CH) that may be complicated by hemolytic uremic syndrome (HUS). The main STEC virulence factor is Shiga toxin encoded by the stx gene, located in the genome of a bacteriophage integrated into the bacterial chromosome. The serotype O26:H11 is the second HUS-causing serotype worldwide (after O157:H7), and the first found in dairy products such as raw-milk cheeses. A small number of HUS cases identified each year in France are caused by serotype O26:H11...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28288854/irinotecan-induced-bile-acid-malabsorption-is-associated-with-down-regulation-of-ileal-asbt-slc10a2-in-mice
#3
A-Xi Shi, Yan Zhou, Xiao-Yi Zhang, Yan-Shu Zhao, Hong-Yan Qin, Yan-Ping Wang, Xin-An Wu
Irinotecan, (CPT-11), an antitumor agent primarily used for the treatment of solid tumors, has often compromised clinical application due to the inducement of severe delay-onset diarrhea. Bile acid malabsorption (BAM) is widely accepted as the common cause of diarrhea. However, whether CPT-11-induced diarrhea has correlation with BAM is unknown. The aim of this study was to investigate the effect of CPT-11 on the bile acid homeostasis in mice. The mice were administrated with CPT-11 intravenously for four consecutive days...
March 10, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28096487/a-clostridium-difficile-specific-gel-forming-protein-required-for-optimal-spore-germination
#4
M Lauren Donnelly, William Li, Yong-Qing Li, Lauren Hinkel, Peter Setlow, Aimee Shen
Clostridium difficile is a Gram-positive spore-forming obligate anaerobe that is a leading cause of antibiotic-associated diarrhea worldwide. In order for C. difficile to initiate infection, its aerotolerant spore form must germinate in the gut of mammalian hosts. While almost all spore-forming organisms use transmembrane germinant receptors to trigger germination, C. difficile uses the pseudoprotease CspC to sense bile salt germinants. CspC activates the related subtilisin-like protease CspB, which then proteolytically activates the cortex hydrolase SleC...
January 17, 2017: MBio
https://www.readbyqxmd.com/read/27777888/ursodeoxycholic-acid-in-treatment-of-non-cholestatic-liver-diseases-a-systematic-review
#5
Jillian Reardon, Trana Hussaini, Majid Alsahafi, Vladimir Marquez Azalgara, Siegfried R Erb, Nilufar Partovi, Eric M Yoshida
Aims: To systematically evaluate the literature for evidence to support the use of bile acids in non-cholestatic liver conditions. Methods: Searches were conducted on the databases of Medline (1948-March 31, 2015), Embase (1980-March 31, 2015) and the Cochrane Central Register of Controlled Trials, and on Google and Google Scholar to identify articles describing ursodeoxycholic acid (UDCA) and its derivatives for non-cholestatic hepatic indications. Combinations of the following search terms were used: ursodeoxycholic acid, ursodiol, bile acids and/or salts, non alcoholic fatty liver, non alcoholic steatohepatitis, fatty liver, alcoholic hepatitis, alcohol, liver disease, autoimmune, autoimmune hepatitis, liver transplant, liver graft, transplant rejection, graft rejection, ischemic reperfusion injury, reperfusion injury, hepatitis B, hepatitis C, viral hepatitis, chronic hepatitis, acute hepatitis, transaminases, alanine transaminase, liver enzymes, aspartate aminotransferase, gamma-glutamyl transferase, gamma-glutamyl transpeptidase, bilirubin, alkaline phosphatase...
September 28, 2016: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/27607341/bariatric-surgery-in-managing-diabetes-mellitus
#6
Mitchell S Roslin, Courtney N Cripps
PURPOSE OF REVIEW: Obesity is a worldwide epidemic, having profound effects on Western populations. Bariatric surgery has long been employed to treat obesity and its related comorbidities. Over time, researchers have amassed significant data to support bariatric surgery in the pursuit of treating diabetes mellitus. This review serves to introduce the most recent findings and their relation to the various bariatric surgical options as bariatric surgery will continue to cement itself in the treatment paradigm of diabetes mellitus...
November 2016: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/27274815/cholera-outbreak-caused-by-drug-resistant-vibrio-cholerae-serogroup-o1-biotype-eltor-serotype-ogawa-in-nepal-a-cross-sectional-study
#7
Pappu Kumar Gupta, Narayan Dutt Pant, Ramkrishna Bhandari, Padma Shrestha
BACKGROUND: Cholera is a major cause of mortality and morbidity in underdeveloped countries including Nepal. Recently drug resistance in Vibrio cholerae has become a serious problem mainly in developing countries. The main objectives of our study were to investigate the occurrence of Vibrio cholerae in stool samples from patients with watery diarrhea and to determine the antimicrobial susceptibility patterns of V. cholerae isolates. METHODS: A total of 116 stool samples from patients suffering from watery diarrhea during July to December 2012 were obtained from outbreak areas from all over Nepal...
2016: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/26929656/optimal-management-of-collagenous-colitis-a-review
#8
REVIEW
Aoibhlinn O'Toole
Collagenous colitis (CC) is an increasingly recognized cause of chronic inflammatory bowel disease characterized by watery non-bloody diarrhea. As a lesser studied inflammatory bowel disease, many aspects of the CC's natural history are poorly understood. This review discusses strategies to optimally manage CC. The goal of therapy is to induce clinical remission, <3 stools a day or <1 watery stool a day with subsequent improved quality of life (QOL). Antidiarrheal can be used as monotherapy or with other medications to control diarrhea...
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/26780116/dual-coated-lactic-acid-bacteria-an-emerging-innovative-technology-in-the-field-of-probiotics
#9
REVIEW
Guillermo Alvarez-Calatayud, Abelardo Margolles
Probiotics are living micro-organisms that do not naturally have shelf life, and normally are weakly protected against the digestive action of the GI tract. A new dual coating technology has been developed in an effort to maximize survival, that is, to be able to reach the intestine alive and in sufficient numbers to confer the beneficial health effects on the host. Dual-coating of lactic acid bacteria (LAB) is the result of fourth-generation coating technology for the protection of these bacteria at least 100-fold or greater than the uncoated LAB...
2016: Future Microbiology
https://www.readbyqxmd.com/read/26525925/food-fibre-bile-acids-and-the-pelvic-floor-an-integrated-low-risk-low-cost-approach-to-managing-irritable-bowel-syndrome
#10
REVIEW
Hamish Philpott, Sanjay Nandurkar, John Lubel, Peter R Gibson
Patients presenting with abdominal pain and diarrhea are often labelled as suffering from irritable bowel syndrome, and medications may be used often without success. Advances in the understanding of the causes of the symptoms (including pelvic floor weakness and incontinence, bile salt malabsorption and food intolerance) mean that effective, safe and well tolerated treatments are now available.
October 28, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26505375/intestinal-lactic-acid-bacteria-from-muscovy-duck-as-potential-probiotics-that-alter-adhesion-factor-gene-expression
#11
Z L Xie, D P Bai, L N Xie, W N Zhang, X H Huang, Y F Huang
The purpose of this study was to assess the suitability of lactic acid bacteria (LABs) isolated from Muscovy duck as a potential probiotic. Isolates were identified by targeted polymerase chain reaction and assessed in vitro for probiotic characteristics such as autoaggregation; surface-charge; hydrophobicity; tolerance to acidic pH, bile salts and protease; and expression of genes involved in Caco-2 cell adhesion. The LAB isolates exhibited strong resistance to high bile concentration and acidic pH, produced lactic acid, and bacteriostatic (P < 0...
2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/26496694/identification-of-a-novel-lipoprotein-regulator-of-clostridium-difficile-spore-germination
#12
Kelly A Fimlaid, Owen Jensen, M Lauren Donnelly, Michael B Francis, Joseph A Sorg, Aimee Shen
Clostridium difficile is a Gram-positive spore-forming pathogen and a leading cause of nosocomial diarrhea. C. difficile infections are transmitted when ingested spores germinate in the gastrointestinal tract and transform into vegetative cells. Germination begins when the germinant receptor CspC detects bile salts in the gut. CspC is a subtilisin-like serine pseudoprotease that activates the related CspB serine protease through an unknown mechanism. Activated CspB cleaves the pro-SleC zymogen, which allows the activated SleC cortex hydrolase to degrade the protective cortex layer...
October 2015: PLoS Pathogens
https://www.readbyqxmd.com/read/26138466/therapeutic-targeting-of-bile-acids
#13
REVIEW
Michael Camilleri, Gregory J Gores
The first objectives of this article are to review the structure, chemistry, and physiology of bile acids and the types of bile acid malabsorption observed in clinical practice. The second major theme addresses the classical or known properties of bile acids, such as the role of bile acid sequestration in the treatment of hyperlipidemia; the use of ursodeoxycholic acid in therapeutics, from traditional oriental medicine to being, until recently, the drug of choice in cholestatic liver diseases; and the potential for normalizing diverse bowel dysfunctions in irritable bowel syndrome, either by sequestering intraluminal bile acids for diarrhea or by delivering more bile acids to the colon to relieve constipation...
August 15, 2015: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/26031975/quantifying-bile-acid-malabsorption-helps-predict-response-and-tailor-sequestrant-therapy
#14
Oluwafikunayo Orekoya, John McLaughlin, Eugenia Leitao, Wendy Johns, Simon Lal, Peter Paine
Although recognised as a cause of chronic diarrhoea for over forty years, diagnostic tests and treatments for bile acid malabsorption (BAM) remain controversial. Recent National Institute for Health and Care Excellence (NICE) guidelines highlighted the lack of evidence in the field, and called for further research. This retrospective study explores the BAM subtype and severity, the use and response to bile acid sequestrants (BAS) and the prevalence of abnormal colonic histology. 264 selenium-75-labelled homocholic acid conjugated taurine (SeHCAT)-tested patient records were reviewed and the severity and subtype of BAM, presence of colonic histopathology and response to BAS were recorded...
June 2015: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/25939833/characterization-of-the-dynamic-germination-of-individual-clostridium-difficile-spores-using-raman-spectroscopy-and-differential-interference-contrast-microscopy
#15
Shiwei Wang, Aimee Shen, Peter Setlow, Yong-qing Li
UNLABELLED: The Gram-positive spore-forming anaerobe Clostridium difficile is a leading cause of nosocomial diarrhea. Spores of C. difficile initiate infection when triggered to germinate by bile salts in the gastrointestinal tract. We analyzed germination kinetics of individual C. difficile spores using Raman spectroscopy and differential interference contrast (DIC) microscopy. Similar to Bacillus spores, individual C. difficile spores germinating with taurocholate plus glycine began slow leakage of a ∼15% concentration of a chelate of Ca(2+) and dipicolinic acid (CaDPA) at a heterogeneous time T1, rapidly released CaDPA at Tlag, completed CaDPA release at Trelease, and finished peptidoglycan cortex hydrolysis at Tlysis...
July 2015: Journal of Bacteriology
https://www.readbyqxmd.com/read/25930081/colonic-mucosal-gene-expression-and-genotype-in-irritable-bowel-syndrome-patients-with-normal-or-elevated-fecal-bile-acid-excretion
#16
Michael Camilleri, Paula Carlson, Andres Acosta, Irene Busciglio
The mucosal gene expression in rectosigmoid mucosa (RSM) in irritable bowel syndrome with diarrhea (IBS-D) is unknown. Our objectives were, first, to study mRNA expression [by RT(2) PCR of 19 genes pertaining to tight junctions, immune activation, intestinal ion transport and bile acid (BA) homeostasis] in RSM in IBS-D patients (n = 47) and healthy controls (n = 17) and study expression of a selected protein (PDZD3) in 10 IBS-D patients and 4 healthy controls; second, to assess RSM mRNA expression according to genotype and fecal BA excretion (high ≥ 2,337 μmol/48 h); and third, to determine whether genotype or mucosal mRNA expression is associated with colonic transit or BA parameters...
July 1, 2015: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/25858478/randomised-clinical-trial-colestyramine-vs-hydroxypropyl-cellulose-in-patients-with-functional-chronic-watery-diarrhoea
#17
RANDOMIZED CONTROLLED TRIAL
F Fernández-Bañares, M Rosinach, M Piqueras, A Ruiz-Cerulla, I Modolell, Y Zabana, J Guardiola, M Esteve
BACKGROUND: Idiopathic bile acid malabsorption (BAM) has been suggested as a cause of chronic watery diarrhoea, with a response to colestyramine in 70% of patients. However, the efficacy of this drug has never been investigated in placebo-controlled trials. AIM: To evaluate the efficacy of colestyramine as compared with hydroxypropyl cellulose in the treatment of functional chronic watery diarrhoea. METHODS: Patients with chronic watery diarrhoea were randomly assigned to groups given colestyramine sachets 4 g twice daily (n = 13) or identical hydroxypropyl cellulose sachets (n = 13) for 8 weeks...
June 2015: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/25736145/editorial-colesevelam-effects-on-faecal-bile-acids-in-ibs-with-diarrhoea-author-s-reply
#18
EDITORIAL
M Camilleri
No abstract text is available yet for this article.
April 2015: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/25736144/editorial-colesevelam-effects-on-faecal-bile-acids-in-ibs-with-diarrhoea
#19
EDITORIAL
J R F Walters, R N Appleby
No abstract text is available yet for this article.
April 2015: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/25594801/effect-of-colesevelam-on-faecal-bile-acids-and-bowel-functions-in-diarrhoea-predominant-irritable-bowel-syndrome
#20
M Camilleri, A Acosta, I Busciglio, A Boldingh, R B Dyer, A R Zinsmeister, A Lueke, A Gray, L J Donato
BACKGROUND: About one-third of patients with IBS-diarrhoea (irritable bowel syndrome-D) have evidence of increased bile acid synthesis or excretion. AIMS: To assess effects of the bile acid sequestrant, colesevelam, on faecal excretion of BAs, hepatic BA synthesis and diarrhoea in IBS-D; to appraise whether individual or random stool samples accurately reflect 48-h total faecal bile acid excretion and proportions of the main bile acids excreted and to study the faecal fat excretion in response to colesevelam...
March 2015: Alimentary Pharmacology & Therapeutics
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