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https://www.readbyqxmd.com/read/29429200/-outcome-of-pediatric-extracorporeal-membrane-oxygenation-in-a-single-center
#1
Q Bao, X Y Hong, Y Y Liu, X J Zhang, H T Gao, Z C Feng
Objective: To investigate the application and outcome of pediatric extracorporeal membrane oxygenation (ECMO) in a single center. Methods: The clinical data of 52 pediatric patients with cardiopulmonary failure received ECMO support in Bayi Children's Hospital Affiliated to General Hospital of Beijing Military Command of PLA were collected from January 2012 to October 2016. All patients were divided into two stages by time. January 2012 to December 2014 was stage one. January 2015 to October 2016 was stage two...
February 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29413771/population-based-epidemiology-of-9767-ankle-fractures
#2
Rasmus Elsoe, Svend E Ostgaard, Peter Larsen
BACKGROUND: The purpose was to provide up-to-date information concerning the incidence of ankle fractures in a large and complete population including all age groups, spanning a decade, and report the distribution of fractures, trauma mechanism and patient baseline demographics. METHODS: Population-based epidemiological study of all patients treated for an ankle fracture in a 10-year period from 2005 to 2014. RESULTS: A total of 9767 patients with ankle fractures were treated between 2005 and 2014...
February 2018: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29359347/shuffling-peptides-to-create-t-cell-epitopes-does-the-immune-system-play-cards
#3
REVIEW
Stuart I Mannering, Michelle So, Colleen M Elso, Thomas W H Kay
For a long time, immunologists have believed that classical CD4+ and CD8+ T cells recognize peptides (referred to as epitopes), derived from protein antigens presented by MHC/HLA class I or II. Over the past 10-15 years, it has become clear that epitopes recognized by CD8+, and more recently CD4+ T cells, can be formed by protein splicing. Here, we review the discovery of spliced epitopes recognized by tumor-specific human CD8+ T cells. We discuss how these epitopes are formed and some of the unusual variants that have been reported...
January 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29336834/an-overview-of-medical-ecmo-for-neonates
#4
REVIEW
Kathryn Fletcher, Rachel Chapman, Sarah Keene
Extracorporeal membrane oxygenation (ECMO), a life-saving therapy for respiratory and cardiac failure, was first used in neonates in the 1970s. The indications and criteria for ECMO have changed over the years, but it continues to be an important option for those who have failed other medical therapies. Since the Extracorporeal Life Support Organization (ELSO) Registry was established in 1989, more than 29,900 neonates have been placed on ECMO for respiratory failure, with 84% surviving their ECMO course, and 73% surviving to discharge or transfer...
January 11, 2018: Seminars in Perinatology
https://www.readbyqxmd.com/read/29336833/education-for-ecmo-providers-using-education-science-to-bridge-the-gap-between-clinical-and-educational-expertise
#5
REVIEW
Lindsay Johnston, Susan B Williams, Anne Ades
A well-organized educational curriculum for the training of both novice and experienced ECMO providers is critical for the continued function of an institutional ECMO program. ELSO provides guidance for the education for ECMO specialists, physicians and staff, which incorporates "traditional" instructor-centered educational methods, such as didactic lectures and technical skill training. Novel research suggests utilization of strategies that align with principles of adult learning to promote active learner involvement and reflection on how the material can be applied to understand existing and new constructs may be more effective...
January 11, 2018: Seminars in Perinatology
https://www.readbyqxmd.com/read/29206096/danish-translation-of-the-foot-and-ankle-outcome-score
#6
Peter Larsen, Anne Marie Boe, Annika B Iyer, Rasmus Elsøe
INTRODUCTION: The Foot and Ankle Outcome Score (FOAS) is a standardized instrument used to report on injury-specific clinical status following foot- and ankle-related problems. The primary aim of this study was to translate and conduct a cross-cultural adaptation of the FAOS into a Danish setting, including testing absolute agreement and the test-retest reliability of the questionnaire. METHODS: Translation of the FAOS questionnaire was 
carried out according to the Principles of Good Practice for the Translation and Cultural Adaptation Process for Patient-
Reported Outcomes Measures: report of the Society for Pharmacoeconomics and Outcomes Research Task Force 
for Translation and Cultural Adaptation...
December 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/29144241/shifting-risks-and-conflicting-outcomes-ecmo-for-neonates-with-congenital-diaphragmatic-hernia-in-the-modern-era
#7
Joseph W Turek, Joseph R Nellis, Brenton G Sherwood, Meera Kotagal, Andrew L Mesher, Ravi R Thiagarajan, Sonali S Patel, Jeffrey R Avansino, Peter T Rycus, D Michael McMullan, Thomas V Brogan
OBJECTIVES: To update previously described trends for neonates with congenital diaphragmatic hernia (CDH) receiving ECMO with changes in recommendations for care, and to determine how recent advancements in respiratory care have affected this patient population. STUDY DESIGN: This study is a retrospective review of more than 2500 neonates with CDH who received ECMO listed in the Extracorporeal Life Support Organization (ELSO) registry. Cochran-Armitage and multivariate regression analyses were used to analyze changes in the patient population over time and in mortality-related risk factors...
November 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29116356/population-based-epidemiology-and-incidence-of-distal-femur-fractures
#8
Rasmus Elsoe, Adriano Axel Ceccotti, Peter Larsen
PURPOSE: The literature lacks recent epidemiological studies on the incidence, trauma mechanism and fracture classification of distal femur fractures. The aim of the present study was to provide up-to-date information concerning the incidence of distal femur fractures in a large and complete population and to report on the distribution of fracture classification, trauma mechanisms and patient baseline demographics. METHODS: The approach for this study was via a retrospective reviews of records...
November 7, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29103207/complex-tibial-fractures-are-associated-with-lower-social-classes-and-predict-early-exit-from-employment-and-worse-patient-reported-qol-a-prospective-observational-study-of-46-complex-tibial-fractures-treated-with-a-ring-fixator
#9
Rasmus Elsoe, Peter Larsen, Juozas Petruskevicius, Søren Kold
The long-term outcomes following complex fractures of the tibia are reported to carry a risk of knee pain, malalignment, articular injury and post-traumatic osteoarthritis. The main objective of this study was to account for the patient-reported quality of life (QOL) 12 months after ring fixator removal in patients with a complex tibial fracture. Secondary objectives included a review of the socio-economic characteristics of the patient group and the rate of return to work in the study period. A prospective follow-up study was conducted of 60 patients with complex fractures of the tibia treated with ring external fixation...
November 4, 2017: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/28993848/altered-long-term-health-related-quality-of-life-in-patients-following-patella-fractures-a-long-term-follow-up-study-of-49-patients
#10
J O Vedel, S Vistrup, P Larsen, R Elsoe
INTRODUCTION: The primary aim was to investigate the health-related quality of life (HRQOL) in patients treated for a patella fracture. The explorative aim was to report the associations between HRQOL, knee osteoarthritis, muscle strength and gait function. METHODS: The study design was a cohort study. Patients who were treated for patella fractures at Aalborg University Hospital, Denmark between January 2006 and December 2009 were identified. Patients between the age of 18 and 80 were included...
October 9, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28985704/extracorporeal-membrane-oxygenation-for-kawasaki-disease-two-case-reports-and-the-extracorporeal-life-support-organization-experience-1999-2015
#11
Derek Best, Johnny Millar, Igor Kornilov, Yury Sinelnikov, Roberto Chiletti, Peter Rycus, Warwick Butt
Kawasaki disease is usually a limited illness of early childhood. However, life-threatening cardiac manifestations can occur, either at acute presentation or as a consequence of coronary arterial involvement. We report the successful use of veno-arterial (VA) extracorporeal membrane oxygenation (ECMO) for cardiac support in two children with Kawasaki disease: one with acute Kawasaki disease shock syndrome, the other with complications of coronary arteritis and subsequent surgery. We also reviewed the reported experience in the ELSO database and available literature...
October 2017: Perfusion
https://www.readbyqxmd.com/read/28979790/differential-diagnosis-of-multiple-sclerosis-in-latin-america
#12
REVIEW
Y D Fragoso, F G Elso, A Carrá
Improvement of multiple sclerosis (MS) diagnoses leads to earlier and correct disease management. The differential diagnostic workup for MS comprises a large variety of medical conditions. There are general guidelines and criteria for diagnosing MS worldwide, but awareness of regional differences needs to be kept in mind. Latin American patients who are screened for MS diagnoses may require an approach that is not exactly the same as that used for patients in North America, western Europe or Asia. In the present review, the conditions that are important for the differential diagnoses of MS in Latin America are reviewed...
July 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/28941930/cannulating-the-contraindicated-effect-of-low-birth-weight-on-mortality-in-neonates-with-congenital-diaphragmatic-hernia-on-extracorporeal-membrane-oxygenation
#13
Patrick T Delaplain, Lishi Zhang, Yanjun Chen, Danh V Nguyen, Matteo Di Nardo, John Patrick Cleary, Peter T Yu, Yigit S Guner
BACKGROUND/PURPOSE: Restrictions for ECMO in neonates include birth weight less than 2kg (BW <2kg) and/or gestational age less than 34weeks (GA <34weeks). We sought to describe their relationship on mortality. METHODS: Neonates with a primary diagnosis code of CDH were identified in the Extracorporeal Life Support Organization (ELSO) registry, and logistic regression models were used to examine the effect of BW <2kg and GA <34weeks on mortality. RESULTS: We identified 7564 neonates with CDH...
December 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28895699/association-between-sleep-related-breathing-disorders-and-academic-performance-among-children-from-concepci%C3%A3-n-chile
#14
Darwin Gatica, Iván Rodríguez-Núñez, Daniel Zenteno, María J Elso, Juan J Montesinos, Carlos Manterola
The objective of this study was to establish an association between academic performance in Math, Language Arts, and Science and the presence of sleep-related breathing disorders (SRBDs) among healthy schoolchildren from the city of Concepción, Chile. Healthy children were defined as those without comorbidities. Outcome measures of interest included the analysis of academic performance in Math, Language Arts, and Science and the presence of SRBD assessed using the Pediatric Sleep Questionnaire. Two-hundred and fifty-six children were included in the study (59...
October 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28885377/clinical-pearls-in-venovenous-extracorporeal-life-support-for-adult-respiratory-failure
#15
REVIEW
Chee Kiang Tay, Kiick Sung, Yang Hyun Cho
Extracorporeal life support (ECLS) has been widely utilized to treat neonatal respiratory failure for two decades. However, its uptake in the case of adult respiratory failure has been slow because of a paucity of quality evidence and a sluggish tempo of ECLS-related technological advances. In recent years, interest in ECLS has been piqued after encouraging results were reported from its use during the 2009 H1N1 influenza pandemic. In a world constantly under threat from another influenza epidemic or deadly novel respiratory infection, e...
January 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28789990/descriptive-analysis-of-extracorporeal-cardiopulmonary-resuscitation-following-out-of-hospital-cardiac-arrest-an-elso-registry-study%C3%A2
#16
Nathan L Haas, Ryan A Coute, Cindy H Hsu, James A Cranford, Robert W Neumar
AIM: Extracorporeal cardiopulmonary resuscitation (ECPR) is an emerging therapy for refractory cardiac arrest. The purpose of this study was to analyze and report characteristics and outcomes of adult patients treated with ECPR after out-of-hospital cardiac arrest (OHCA) in a large international registry. METHODS: The Extracorporeal Life Support Organization's Extracorporeal Life Support Registry was queried for adult cardiac arrests with arrest location of "EMT Transport" or "Outside Hospital...
October 2017: Resuscitation
https://www.readbyqxmd.com/read/28643997/brain-monitoring-in-adult-and-pediatric-ecmo-patients-the-importance-of-early-and-late-assessments
#17
Roberto Lorusso, Fabio S Taccone, Mirko Belliato, Thijs Delnoij, Paolo Zanatta, Mirjana Cvetkovic, Mark Davidson, Jan Belohlavek, Nashwa Matta, Carl Davis, Hanneke Ijsselstijn, Thomas Mueller, Ralf Muellenbach, Dirk Donker, Piero David, Matteo Di Nardo, Dirk Vlasselaers, Dinis Dos Reis Miranda, Aparna Hoskote
Monitoring brain integrity and neurocognitive function is a new and important target for the management of a patient treated with extracorporeal membrane oxygenation (ECMO), in particular because of the increasing awareness of cerebral abnormalities that may potentially occur in this setting. Continuous regular monitoring, as well as repeated assessment for cerebral complications has become an essential element of the ECMO patient management. Besides well-known complications, like bleeding, ischemic stroke, seizures, and brain hypoperfusion, other less defined yet relevant injury and clinical manifestations are increasingly reported and impacting on ECMO patient prognosis at short term...
October 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28641755/ecmo-in-cdh-is-there-a-role
#18
David W Kays
Despite wide use and decades of experience, survival of congenital diaphragmatic hernia (CDH) patients treated with extra-corporeal membrane oxygenation (ECMO), as reported by the extra-corporeal life support organization (ELSO), remains unchanged at 50%. High-survival rates both with and without utilizing ECMO have been reported, fueling questions about the utility of ECMO support in this difficult population. This review looks at data from the Congenital Diaphragmatic Hernia Study Group and individual center reports, to evaluate the role of ECMO in CDH, focusing on defining the patients most likely to benefit, and discussing how those benefits can best be achieved...
June 2017: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/28557863/pediatric-extracorporeal-life-support-organization-registry-international-report-2016
#19
Ryan P Barbaro, Matthew L Paden, Yigit S Guner, Lakshmi Raman, Lindsay M Ryerson, Peta Alexander, Viviane G Nasr, Melania M Bembea, Peter T Rycus, Ravi R Thiagarajan
The purpose of this report is to describe the international growth, outcomes, complications, and technology used in pediatric extracorporeal life support (ECLS) from 2009 to 2015 as reported by participating centers in the Extracorporeal Life Support Organization (ELSO). To date, there are 59,969 children who have received ECLS in the ELSO Registry; among those, 21,907 received ECLS since 2009 with an overall survival to hospital discharge rate of 61%. In 2009, 2,409 ECLS cases were performed at 157 centers...
July 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28479051/asymmetry-in-gait-pattern-following-bicondylar-tibial-plateau-fractures-a-prospective-one-year-cohort-study
#20
Rasmus Elsoe, Peter Larsen
INTRODUCTION: Despite the high number of studies evaluating outcomes following tibial plateau fractures, the literature lacks studies including the objective assessment of gait pattern. The purpose of the present study was to evaluate asymmetry in gait patterns at 12 months after frame removal following ring fixation of a tibial plateau fracture. PATIENTS AND METHODS: The study design was a prospective cohort study. The primary outcome measurement was the gait patterns 12 months after frame removal measured with a pressure-sensitive mat...
July 2017: Injury
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