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https://www.readbyqxmd.com/read/28088173/high-risk-human-papillomavirus-infection-and-abnormal-cervical-cytology-among-nepali-and-bhutanese-refugee-women-living-in-eastern-nepal
#1
Madhav P Bhatta, Derek C Johnson, Mingma Lama, Shilu Aryal, Pema Lhaki, Sadeep Shrestha
BACKGROUND: Cervical cancer is the leading cause of cancer morbidity and mortality among women in Nepal and Bhutan. Data on high-risk human papillomavirus (HR-HPV) infection and cervical abnormalities among Nepali and Bhutanese women are sparse. The objectives of this study were to assess and compare the prevalence of HR-HPV infection and cervical abnormalities among Nepali and Bhutanese women living in Jhapa District in eastern Nepal; and examine the risk factors for HR-HPV infection and cervical abnormalities in those women...
January 14, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28080186/satisfaction-with-sex-life-in-sexually-active-heterosexual-couples-dealing-with-breast-cancer-a-nationwide-longitudinal-study
#2
Nina Rottmann, Dorte Gilså Hansen, René dePont Christensen, Mariët Hagedoorn, Morten Frisch, Anne Nicolaisen, Niels Kroman, Henrik Flyger, Christoffer Johansen
BACKGROUND: A breast cancer (BC) diagnosis can profoundly affect the sex life of patient and partner within a couple. The purpose of the present study is to examine whether individual and partner sexual functioning, affectionate behavior, emotional closeness and depressive symptoms are associated with change over time in satisfaction with sex life of sexually active heterosexual couples dealing with BC and to explore whether the associations differ between patients and partners after adjustment for basic sociodemographic characteristics, comorbidity and BC treatment...
January 12, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28080157/detection-of-recurrence-in-early-stage-endometrial-cancer-the-role-of-symptoms-and-routine-follow-up
#3
Mette Moustgaard Jeppesen, Ole Mogensen, Dorte Gilså Hansen, Maria Iachina, Malene Korsholm, Pernille Tine Jensen
BACKGROUND: Considerable controversy remains as to the optimal organization of endometrial cancer follow-up. AIM: To evaluate the relationship between the way recurrence was detected and survival after treatment for endometrial cancer. Further, to identify characteristics associated with a pre-scheduled examination in women with symptomatic recurrence. MATERIAL AND METHODS: All women with early stage endometrial cancer during 2005-2009 were included in a population-based historical cohort derived from the Danish Gynecological Cancer Database...
January 12, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28070215/multiple-hpv-infections-in-female-sex-workers-in-western-kenya-implications-for-prophylactic-vaccines-within-this-sub-population
#4
Sonia Menon, Davy van den Broeck, Rodolfo Rossi, Emilomo Ogbe, Hillary Mabeya
BACKGROUND: Whilst the imputed role of High Risk (HR) HPV infection in the development of cervical lesions and cancer has been established, the high number of HPV genotypes that Female Sex workers (FSW) harbour warrants that the synergistic effects of potential HR (pHR) and HR HPV genotypes be elucidated to assess the potential impact of prophylactic vaccines. This population in Kenya also harbours a number of other vaginal infections and STIs, including bacterial vaginosis (BV), trichomonas vaginalis (TV) and candida spp...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28061842/feasibility-of-thermocoagulation-in-a-screen-and-treat-approach-for-the-treatment-of-cervical-precancerous-lesions-in-sub-saharan-africa
#5
Manuela Viviano, Bruno Kenfack, Rosa Catarino, Eveline Tincho, Liliane Temogne, Anne-Caroline Benski, Pierre-Marie Tebeu, Ulrike Meyer-Hamme, Pierre Vassilakos, Patrick Petignat
BACKGROUND: The use of thermocoagulation for the treatment of cervical precancerous lesions has recently generated a great deal of interest. Our aim was to determine the feasibility of this outpatient procedure in the context of a cervical cancer (CC) screen-and-treat campaign in sub-Saharan Africa. METHODS: Between July and December 2015, women living in the area of Dschang (Cameroon) aged between 30 and 49 years, were enrolled in a CC screening study. HPV self-sampling was performed as a primary screening test and women who were either "HPV 16/18/45-positive" or "positive to other HPV types and to VIA" were considered screen-positive, thus requiring further management...
January 7, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28057913/humoral-hypercalcemia-in-uterine-cancers-a-case-report-and-literature-review
#6
Vijeyaluxmy Motilal Nehru, Gwenalyn Garcia, Juan Ding, Fanyi Kong, Qun Dai
BACKGROUND Paraneoplastic hypercalcemia is a well-described complication associated with a variety of malignancies. However, its incidence in gynecological malignancies is low. CASE REPORT A 53-year-old woman presented with progressive abdominal distention and irregular vaginal bleeding of several weeks' duration. A contrast CT abdomen and pelvis was significant for a mass in the lower uterine/cervical region, multiple peritoneal and omental masses, enlarged pelvic and paraaortic lymph nodes, and large-volume ascites...
January 6, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28049151/modulation-of-microrna-mrna-target-pairs-by-human-papillomavirus-16-oncoproteins
#7
Mallory E Harden, Nripesh Prasad, Anthony Griffiths, Karl Munger
: The E6 and E7 proteins are the major oncogenic drivers encoded by high-risk human papillomaviruses (HPVs). While many aspects of the transforming activities of these proteins have been extensively studied, there are fewer studies that have investigated how HPV E6/E7 expression affects the expression of cellular noncoding RNAs. The goal of our study was to investigate HPV16 E6/E7 modulation of cellular microRNA (miR) levels and to determine the potential consequences for cellular gene expression...
January 3, 2017: MBio
https://www.readbyqxmd.com/read/28048727/su-f-t-35-optimization-of-bladder-and-rectal-doses-using-a-multi-lumen-intracavitary-applicator-for-gynecological-brachytherapy
#8
S Laoui, S Dietrich, V Sehgal, M Al-Ghazi
PURPOSE: Radiation dose delivery for endometrial cancer using HDR techniques is limited by dose to bladder and rectum. A dosimetric study was performed using Varian Capri vaginal brachytherapy applicator to determine the optimal channel configuration which minimizes dose to bladder and rectum, while providing good target coverage. METHODS: A total of 17 patients, 63 plans clinically delivered, and 252 simulated plans using Varian BrachyVision planning system were generated to investigate optimal channel configuration which results in minimum dose to bladder and rectum while providing adequate target coverage...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048667/su-f-t-65-automatictreatment-planning-for-high-dose-rate-hdr-brachytherapy-with-a-vaginalcylinder-applicator
#9
Y Zhou, J Tan, S Jiang, K Albuquerque, X Jia
PURPOSE: High dose rate (HDR) brachytherapy treatment planning is conventionally performed in a manual fashion. Yet it is highly desirable to perform computerized automated planning to improve treatment planning efficiency, eliminate human errors, and reduce plan quality variation. The goal of this research is to develop an automatic treatment planning tool for HDR brachytherapy with a cylinder applicator for vaginal cancer. METHODS: After inserting the cylinder applicator into the patient, a CT scan was acquired and was loaded to an in-house developed treatment planning software...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048067/su-f-t-36-dosimetric-comparison-of-point-based-vs-target-based-prescription-for-intracavitary-brachytherapy-in-cancer-of-the-cervix
#10
M Ashenafi, D McDonald, J Peng, C Mart, N Koch, L Cooper, K Vanek
PURPOSE: Improved patient imaging used for planning the treatment of cervical cancer with Tandem and Ovoid (T&O) Intracavitary high-dose-rate brachytherapy (HDR) now allows for 3D delineation of target volumes and organs-at-risk. However, historical data relies on the conventional point A-based planning technique. A comparative dosimetric study was performed by generating both target-based (TBP) and point-based (PBP) plans for ten clinical patients. METHODS: Treatment plans created using Elekta Oncentra v...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048049/su-f-t-25-design-and-implementation-of-a-multi-purpose-applicator-for-pelvic-brachytherapy-applications
#11
J Bogue, E Parsai
PURPOSE: The current generation of inflatable multichannel brachytherapy applicators, such as the Varian Capri, have limited implementation to only vaginal and rectal cancers. While there are similar designs utilizing rigid, non-inflatable applicators, these alternatives could cause increased dose to surrounding tissue due to air gaps. Modification of the Capri could allow for easier treatment planning by reducing the number of channels and increased versatility by modifying the applicator to include an attachable single tandem for cervical or multiple tandems for endometrial applications...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047446/su-f-t-132-variable-rbe-models-predict-possible-underestimation-of-vaginal-dose-for-anal-cancer-patients-treated-using-single-field-proton-treatments
#12
A McNamara, T Underwood, J Wo, H Paganetti
PURPOSE: Anal cancer patients treated using a posterior proton beam may be at risk of vaginal wall injury due to the increased linear energy transfer (LET) and relative biological effectiveness (RBE) at the beam distal edge. We investigate the vaginal dose received. METHODS: Five patients treated for anal cancer with proton pencil beam scanning were considered, all treated to a prescription dose of 54 Gy(RBE) over 28-30 fractions. Dose and LET distributions were calculated using the Monte Carlo simulation toolkit TOPAS...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047374/su-f-t-55-reproducibility-of-interstitial-hdr-brachytherapy-plans
#13
S Lee, R Ellis, B Traughber, T Podder
PURPOSE: Treating gynecological cancers with interstitial high-dose-rate (HDR) brachytherapy requires precise reconstruction of catheter positions to obtain accurate dosimetric plans. In this study, we investigated the degree of reproducibility of dosimetric plans for Syed HDR brachytherapy. METHODS: We randomly selected five patients having cervix-vaginal cancer who were recently treated in our clinic with interstitial HDR brachytherapy with a prescription dose of 25-30 Gy in five fractions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047249/su-f-t-351-establishing-a-workflow-for-imrt-pre-treatment-reviews-for-nrg-gy006-clinical-trial
#14
T Giaddui, N Li, K Curry, K Moore, L Mell, C Leath, C Kunos, Y Xiao
PURPOSE: To establish a workflow for NRG-GY006 IMRT pre-treatment reviews, incorporating advanced radiotherapy technologies being evaluated as part of the clinical trial. METHODS: Pre-Treatment reviews are required for every IMRT case as part of NRG-GY006 (a randomized phase II trial of radiation therapy and cisplatin alone or in combination with intravenous triapine in women with newly diagnosed bulky stage I B2, stage II, IIIB, or IVA cancer of the uterine cervix or stage II-IVA vaginal cancer...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047139/we-de-201-02-a-statistical-analysis-tool-for-plan-quality-verification-in-hdr-brachytherapy-forward-planning-for-cervix-cancer
#15
R Ma, X Zhu, S Li, D Zheng, Y Lei, S Wang, V Verma, N Bennion, A Wahl, S Zhou
PURPOSE: High Dose Rate (HDR) brachytherapy forward planning is principally an iterative process; hence, plan quality is affected by planners' experiences and limited planning time. Thus, this may lead to sporadic errors and inconsistencies in planning. A statistical tool based on previous approved clinical treatment plans would help to maintain the consistency of planning quality and improve the efficiency of second checking. METHODS: An independent dose calculation tool was developed from commercial software...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046821/su-g-201-07-dosimetric-verification-of-a-3d-printed-hdr-skin-brachytherapy-applicator
#16
K Rasmussen, A Baumgarten, D Stanley, C Pelletier, M Corbett, J Jung, Y Feng, Z Huang, A Ju, T Eng, N Kirby, A Gutierrez, S Stathakis, N Papanikolaou
PURPOSE: The use of radiation as a treatment modality for skin cancer has increased significantly over the last decade with standardized applicators. Utilizing 3D printing, the ability to make applicators specifically designed for each patient's anatomy has become economically feasible. With this in mind it was the aim of this study to determine the dosimetric accuracy of a 3-D printed HDR brachytherapy applicator for the skin. METHODS: A CT reference image was used to generate a custom applicator based on an anthropomorphic head and neck phantom...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046340/su-g-tep2-10-feasibility-of-newly-designed-applicator-for-high-dose-rate-brachytherapy-treatment-of-patients-with-vaginal-vault-recurrence
#17
V Lee, X Huang, M Wong, M Chan, E Chui, S Cheung, R Leung, K Lee, G Law, K Leung, S Tung, D Kwong
PURPOSE: To compare the dose of an in-house 3D-printed gynecology applicator (TMHGA) for vaginal vault recurrence of corpus cancer patients after operation for high dose rate brachytherapy treatment with commercially available applicators. METHODS: A newly designed applicator is made from 3D-printing methods using ABSM30i. The isodose of the applicator is compared with Elekta multi-channel (MC) applicator and titanium Rotterdam applicator with coupling central tube and vaginal cylinder (RC)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042211/a-study-on-the-prevalence-of-genital-trichomoniasis-among-female-outpatients-attending-sexually-transmitted-infection-clinic-in-a-tertiary-care-hospital
#18
Swapna Muthusamy, Selvi Elangovan
INTRODUCTION: Women with high-risk sexual behavior accounts for more than half of the sexually transmitted infection (STI) clinic attendees. The prevalence of trichomoniasis is as low as 5% in the general population to as high as 60% in high-risk population. This infection can pave the way to the acquisition of human immunodeficiency virus and other STIs, vice versa and is even associated with cancer. OBJECTIVES: To identify, isolate and study the prevalence of Trichomonas vaginalis in genital specimens of female outpatients...
January 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28039759/human-papillomavirus-hpv-persistence-and-hpv-31-predict-the-risk-of-recurrence-in-high-grade-vaginal-intraepithelial-neoplasia
#19
Giorgio Bogani, Fabio Martinelli, Antonino Ditto, Francesca Taverna, Claudia Lombardo, Mauro Signorelli, Valentina Chiappa, Umberto Leone Roberti Maggiore, Caterina Fontanella, Ilaria Sabatucci, Chiara Borghi, Dario Recalcati, Alice Indini, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: High-grade vaginal intraepithelial neoplasia (vaginal HSIL) represents an uncommon entity. Here, we sought to identify predictors for recurrence and risk factor for developing genital cancers after primary treatment for vaginal HSIL. METHODS: Data of consecutive 5104 women who had human papillomavirus (HPV) DNA test were searched for identify women with histological confirmed vaginal HSIL. Disease-free interval and the risk of developing HPV-related gynecological cancers were assessed using Kaplan-Meier and Cox proportional hazard models...
December 23, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28039010/comparing-organ-at-risk-doses-for-high-dose-rate-vaginal-brachytherapy-between-three-different-planning-workflows
#20
J D Gruhl, D Zheng, J L Longo, C Enke, A O Wahl
PURPOSE: The aim of this study was to compare the organ-at-risk doses to the rectum and the bladder in postoperative endometrial cancer patients who receive high-dose rate vaginal brachytherapy (HDR-VB), when using three different methods of treatment planning: (Workflow A) individualized treatment planning before every fraction, (Workflow B) individualized treatment planning for first fraction only), and (Workflow C) using a template plan based on applicator choice and prescription specifics without patient-specific imaging or planning (standardized template approach)...
December 27, 2016: Brachytherapy
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