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https://www.readbyqxmd.com/read/28816933/breast-cancer-endometrial-cancer-and-cardiovascular-events-in-participants-who-used-vaginal-estrogen-in-the-women-s-health-initiative-observational-study
#1
Carolyn J Crandall, Kathleen M Hovey, Christopher A Andrews, Rowan T Chlebowski, Marcia L Stefanick, Dorothy S Lane, Jan Shifren, Chu Chen, Andrew M Kaunitz, Jane A Cauley, JoAnn E Manson
OBJECTIVE: To determine the association between use of vaginal estrogen and risk of a global index event (GIE), defined as time to first occurrence of coronary heart disease (CHD), invasive breast cancer, stroke, pulmonary embolism, hip fracture, colorectal cancer, endometrial cancer, or death from any cause. METHODS: For this prospective observational cohort study, we used data from participants of the Women's Health Initiative Observational Study, who were recruited at 40 US clinical centers, aged 50 to 79 years at baseline and did not use systemic estrogen therapy during follow-up (n = 45,663, median follow-up 7...
August 14, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28810691/improvement-of-implantation-potential-in-mouse-blastocysts-derived-from-ivf-by-combined-treatment-with-prolactin-epidermal-growth-factor-and-4-hydroxyestradiol
#2
Miki Takeuchi, Misato Seki, Etsuko Furukawa, Akihito Takahashi, Kyosuke Saito, Mitsuru Kobayashi, Kenji Ezoe, Emiko Fukui, Midori Yoshizawa, Hiromichi Matsumoto
STUDY QUESTION: Can supplementation of medium with prolactin (PRL), epidermal growth factor (EGF) and 4-hydroxyestradiol (4-OH-E2) prior to embryo transfer improve implantation potential in mouse blastocysts derived from IVF? SUMMARY ANSWER: Combined treatment with PRL, EGF and 4-OH-E2 improves mouse blastocyst implantation rates, while alone, each factor is ineffective. WHAT IS KNOWN ALREADY: Blastocyst dormancy during delayed implantation caused by ovariectomy is maintained by continued progesterone treatment in mice, and estrogen injection rapidly activates blastocysts to implantation-induced status in vivo...
August 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28808931/robotic-total-pelvic-exenteration-video-illustrated-technique
#3
Ioannis T Konstantinidis, William Chu, Federico Tozzi, Clayton Lau, Mark Wakabayashi, Kevin Chan, Byrne Lee
BACKGROUND: Robotic-assisted total pelvic exenteration (TPE) can offer a minimally invasive approach to a major multi-organ operation. METHODS: In this video, we summarize a stepwise approach to robotic TPE in a 70 year-old female Jehovah's witness with a history of cervical cancer post-chemoradiation and radical hysterectomy who experienced local recurrence at the vaginal cuff involving the rectum and bladder. RESULTS: The patient was placed in the lithotomy position...
August 14, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28807366/prospective-screening-with-the-validated-opioid-risk-tool-demonstrates-gynecologic-oncology-patients-are-at-low-risk-for-opioid-misuse
#4
Christine Garcia, Carolyn Lefkowits, Elizabeth Pelkofski, Leslie Blackhall, Linda R Duska
OBJECTIVE: To characterize risk for opioid misuse among gynecologic oncology patients. METHODS: The Opioid Risk Tool (ORT), a validated screen for opioid misuse risk, was administered to a convenience sample of patients with gynecologic cancer receiving opioid prescriptions in gynecologic oncology or palliative care clinics from January 2012-June 2016. Demographic and clinical information was abstracted on chart review. The primary outcome was ORT risk level (low vs...
August 11, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28805983/challenges-of-measuring-accurate-estradiol-levels-in-aromatase-inhibitor-treated-postmenopausal-breast-cancer-patients-on-vaginal-estrogen-therapy
#5
Polly Niravath, Raksha Bhat, Mohamed Al-Ameri, Ahmed AlRawi, Claudette Foreman, Meghana V Trivedi
Breast cancer patients who are taking adjuvant Aromatase Inhibitor (AI) therapy typically have extremely low estradiol levels, which are undetectable by routine clinical laboratories. Thus, it becomes difficult to assess the safety of interventions such as low-dose vaginal estrogen, which may increase estradiol levels. In this study, we aimed to assess the utility of enzyme-linked immunosorbent assay (ELISA) to measure low estradiol concentrations in breast cancer survivors on AI therapy treated with either vaginal estrogen or lubricant for atrophic vaginitis as a part of clinical trial...
August 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28803217/accurate-model-based-segmentation-of-gynecologic-brachytherapy-catheter-collections-in-mri-images
#6
Andre Mastmeyer, Guillaume Pernelle, Ruibin Ma, Lauren Barber, Tina Kapur
The gynecological cancer mortality rate, including cervical, ovarian, vaginal and vulvar cancers, is more than 20,000 annually in the US alone. In many countries, including the US, external-beam radiotherapy followed by high dose rate brachytherapy is the standard-of-care. The superior ability of MR to visualize soft tissue has led to an increase in its usage in planning and delivering brachytherapy treatment. A technical challenge associated with the use of MRI imaging for brachytherapy, in contrast to that of CT imaging, is the visualization of catheters that are used to place radiation sources into cancerous tissue...
July 18, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28802913/salvage-high-dose-rate-brachytherapy-and-external-beam-radiotherapy-for-isolated-vaginal-recurrences-of-endometrial-cancer-with-no-prior-adjuvant-therapy
#7
Christopher H Chapman, Kaveh Maghsoudi, Ramey D Littell, Lee-May Chen, I-Chow Hsu
PURPOSE: To evaluate clinical outcomes for isolated vaginal recurrence of endometrial cancer without adjuvant therapy treated with salvage external beam radiation therapy (EBRT) and high-dose-rate CT-based inverse-planned brachytherapy. METHODS AND MATERIALS: Thirty women were included in this retrospective study. Median time to first recurrence was 16.7 months, and median age at recurrence was 73 years. Initial grade was 1 or 2 in 19 patients (63%), and 2009 FIGO stage IA in 19 patients...
August 9, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28796063/descriptive-epidemiological-study-of-vaginal-cancer-using-data-from-the-osaka-japan-population-based-cancer-registry-long-term-analysis-from-a-clinical-viewpoint
#8
Asami Yagi, Yutaka Ueda, Mamoru Kakuda, Yusuke Tanaka, Tomomi Egawa-Takata, Akiko Morimoto, Tadashi Iwamiya, Shinya Matsuzaki, Eiji Kobayashi, Kiyoshi Yoshino, Keisuke Fukui, Yuri Ito, Tomio Nakayama, Tadashi Kimura
Vaginal cancer is such a rare tumor that epidemiological and clinical information for it is based mainly on studies of small numbers of cases. The aim of the present study was to perform a descriptive epidemiological analysis of vaginal cancer using a significantly larger population-based dataset from the Japanese Osaka Cancer Registry.The age-standardized incidence of vaginal cancer per 1,000,000 persons, from 1976 to 2010, was calculated and examined for trends. Relative-survival analysis was applied to estimate a more up-to-date 10-year period calculation, using data from recently followed-up patients...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28795458/a-comprehensive-review-of-sexual-health-concerns-after-cancer-treatment-and-the-biopsychosocial-treatment-options-available-to-female-patients
#9
REVIEW
Carly S Sears, John W Robinson, Lauren M Walker
The repercussions of cancer diagnosis and treatment profoundly impact the sexual wellbeing of women prior to, during, and following cancer treatment. Sexual health concerns are often under-addressed within clinical and research settings, and information tends to be limited to women with breast or gynecological cancers. In this narrative literature review, the authors critically evaluate research published between 1990 and 2016, pertaining to sexual health concerns of women diagnosed with cancer, of any type or stage, and to the psychosocial and biomedical interventions that currently exist for the treatment of sexual health-related side-effects (e...
August 10, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28789851/antibody-persistence-and-evidence-of-immune-memory-at-5years-following-administration-of-the-9-valent-hpv-vaccine
#10
Ana Guevara, Robinson Cabello, Linn Woelber, Edson Duarte Moreira, Elmar Joura, Olaf Reich, Christine Shields, Misoo C Ellison, Amita Joshi, Alain Luxembourg
BACKGROUND: The 9-valent HPV (9vHPV) vaccine was developed to prevent infection and disease related to 9 HPV types (HPV6/11/16/18/31/33/45/52/58) which cause approximately 90% of cervical cancers, HPV-related vulvar, vaginal and anal cancers, and genital warts worldwide. In a pivotal efficacy study, the 9vHPV vaccine prevented infection and disease due to the 9 vaccine types. Duration of protection remains to be determined. Vaccines that induce long-term protection are generally characterized by the generation of immune memory...
August 5, 2017: Vaccine
https://www.readbyqxmd.com/read/28781968/impact-of-ospemifene-on-quality-of-life-and-sexual-function-in-young-survivors-of-cervical-cancer-a-prospective-study
#11
Nicoletta De Rosa, Giada Lavitola, Pierluigi Giampaolino, Ilaria Morra, Carmine Nappi, Giuseppe Bifulco
BACKGROUND: Cervical cancer (CC) treatments impact quality of life (QoL) and sexual function (SF) of survivors. Treatment options to reduce sexual dysfunction are limited. The aim of this study was to assess the effectiveness of ospemifene in CC survivors with clinical signs and symptoms of vulvovaginal atrophy (VVA) focusing on their QoL and SF. MATERIALS AND METHODS: Fifty-two patients with previous diagnosis of stage I-IIa CC suffering from VVA and treated with ospemifene were enrolled into a single arm prospective study...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28771140/cell-damage-caused-by-vaginal-candida-albicans-isolates-from-women-with-different-symptomatologies
#12
Daniella Renata Faria, Karina Mayumi Sakita, Luciene Setsuko Akimoto-Gunther, Érika Seki Kioshima, Terezinha Inez Estivalet Svidzinski, Patrícia de Souza Bonfim-Mendonça
The present study aimed to characterize cell damage caused by vaginal Candida albicans isolates from women with different symptomatologies. It was evaluated 12 clinical isolates of C. albicans from vaginal samples: 4 from asymptomatic women (AS), 4 from women with a single episode of vulvovaginal candidiasis (VVC) and 4 from women with recurrent vulvovaginal candidiasis (RVVC). We evaluated the ability of C. albicans to adhere to human cervical cancer cells (SiHa), the yeast-SiHa cell interactions and cell damage...
August 4, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28768532/estrogen-like-and-tissue-selective-effects-of-7-methoxycoumarin-from-ficus-umbellata-moraceae-an-in-vitro-and-in-vivo-study
#13
Stéphane Zingue, Thomas Michel, Chantal Beatrice Magne Nde, Amstrong Nang Njuh, Julia Cisilotto, Derek Tantoh Ndinteh, Colin Clyne, Xavier Fernandez, Tânia Beatriz Creczynski-Pasa, Dieudonné Njamen
BACKGROUND: Ficus umbellata is a medicinal plant previously shown to endow estrogenic properties. Its major component was isolated and characterized as 7-methoxycoumarin (MC). Noteworthy, coumarins and the respective active metabolite 7-hydroxycoumarin analogs have shown aromatase inhibitory activity, which is of particular interest in the treatment of estrogen-dependent cancers. The present work aimed at evaluating the estrogenic/antiestrogenic effects of MC in vitro and in vivo. METHODS: To do so, in vitro assays using E-screen and reporter gene were done...
August 2, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28764707/delayed-anastomotic-leakage-following-laparoscopic-intersphincteric-resection-for-lower-rectal-cancer-report-of-four-cases-and-literature-review
#14
Masayoshi Iwamoto, Kenji Kawada, Koya Hida, Suguru Hasegawa, Yoshiharu Sakai
BACKGROUND: Anastomotic leakage (AL) is one of the most dreadful postoperative complications because it can result in increased morbidity and mortality as well as poorer long-term prognosis. Although most studies of AL limited their investigation time to a period of 30 days postoperatively, only a few studies have shown that AL can occur after that period. Here, we report four patients of rectal cancer with delayed AL following laparoscopic intersphincteric resection (ISR) and conduct a literature review on delayed AL...
August 1, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28759461/lasers-for-pelvic-floor-dysfunctions-is-there-evidence
#15
Patrick Lang, Mickey Karram
PURPOSE OF REVIEW: The purpose of this review is to discuss the available energy sources used in the vaginal canal that are currently being promoted for certain pelvic floor conditions and explore the body of peer-reviewed literature supporting their use. RECENT FINDINGS: The majority of research has focused on the use of fractional CO2 laser treatment for genitourinary syndrome of menopause (GSM). Most of these studies are nonrandomized prospective studies, but their data consistently shows an improvement in symptoms without significant side effects...
July 29, 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28754175/case-report-term-birth-after-fertility-sparing-treatments-for-stage-ib1-small-cell-neuroendocrine-carcinoma-of-the-cervix
#16
Pei-Ying Wu, Ya-Min Cheng, Geok Huey New, Cheng-Yang Chou, Chun-Ting Chiang, Hung-Wen Tsai, Yu-Fang Huang
BACKGROUND: Advances in cervical cancer management for childbearing women have led to less radical approaches. Use of fertility-sparing treatment to treat small cell neuroendocrine carcinoma (SCNEC) is challenging owing to the aggressive nature of the disease, even in early stage disease. CASE PRESENTATION: A 25-year-old nulligravida woman presented with malodorous vaginal discharge and was diagnosed to have an exophytic cervical SCNEC. A magnetic resonance image scan showed no evidence of parametrial invasion or distant metastasis...
July 28, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28750150/are-checkpoint-inhibitors-a-valuable-option-for-metastatic-or-unresectable-vulvar-and-vaginal-melanomas
#17
G Quéreux, S Wylomanski, R Bouquin, M Saint-Jean, L Peuvrel, A C Knol, M Hanf, B Dréno
Immune checkpoint inhibitors might be therapeutic options for unresectable or metastatic melanomas of the vulva and vagina but data available in the literature in these melanomas are very limited (1)(2)(3)(4) . The aim of this retrospective study was to investigate the effect of anti-cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) and anti-programmed death 1 (PD-1) antibodies in patients treated in our Skin Cancer Department for unresectable or metastatic vulvar or vaginal melanoma since 2013. This article is protected by copyright...
July 27, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28739704/vaginal-and-urine-self-sampling-compared-to-cervical-sampling-for-hpv-testing-with-the-cobas-4800-hpv-test
#18
Katrin Christine Asciutto, Anna J Henningsson, Henrik Borgfeldt, Lotten Darlin, Christer Borgfeldt
BACKGROUND/AIM: To compare human papillomavirus (HPV) DNA detection in self-collected vaginal and urine samples with clinician-taken cervical samples in relation to histology. MATERIALS AND METHODS: Self-collected vaginal, urine and clinician-taken cervical samples were analyzed from 218 women with the Cobas 4800 HPV test (Roche Molecular Diagnostics). RESULTS: The sensitivity for detection of HPV in the vaginal self-sampling test was 96.4% and in urine was 83...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28734829/feasibility-of-prophylactic-salpingectomy-during-vaginal%C3%A2-hysterectomy
#19
Danielle D Antosh, Rachel High, Heidi W Brown, Sallie S Oliphant, Husam Abed, Nisha Philip, Cara L Grimes
BACKGROUND: The American Congress of Obstetricians and Gynecologists recommends that "the surgeon and patient discuss the potential benefits of the removal of the fallopian tubes during a hysterectomy in women at population risk of ovarian cancer who are not having an oophorectomy," resulting in an increasing rate of salpingectomy at the time of hysterectomy. Rates of salpingectomy are highest for laparoscopic and lowest for vaginal hysterectomy. OBJECTIVE: The primary objective of this study was to determine the feasibility of bilateral salpingectomy at the time of vaginal hysterectomy...
July 20, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28729098/a-multicentre-retrospective-review-of-clinical-characteristics-of-uterine-sarcoma
#20
Marta Wais, Elissa Tepperman, Marcus Q Bernardini, Lilian T Gien, Waldo Jimenez, Ally Murji
OBJECTIVE: Professional societies have recently urged gynaecologists to counsel patients about the risks of encountering uterine sarcoma at fibroid surgery especially when morcellation is used. Our objective was to learn the preoperative and postoperative characteristics of patients with uterine sarcoma to better counsel patients undergoing surgery for presumably benign fibroids. METHODS: This is a multicentre, retrospective cohort study. Three academic tertiary cancer centres in Southern Ontario over a 13-year period (2001-2014)...
August 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
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